Oral fast-disintegrating dosage forms, also known as ‘fast-disintegrating’ or ‘fast-dissolving’ dosage forms, are a relativelynovel dosage technology that involves the rapid disintegration or dissolution of the dosage form. The objective of present study was to demonstrate pregelatinized hyd...

Optimization of the preparation of hydroxypropylated, phosphorylated and hydroxypropyl-phosphorylated glutinous rice starch was performed using a response surface methodology comprising three variables at three levels. Multi-linear regression was used to fit the degree of substitution and molar ...

Considering the advantages of orally disintegrating films as alternative pharmaceutical dosage forms, the objective of this work was to develop and evaluate different formulations of orally disintegrating films based on pre-gelatinised starch (%S) and hydroxypropyl methylcellulose (%HPMC), with ...

Previous studies have found that the proportion of long chains of amylopectin correlates to its functional and nutritional properties. As a possible explanation of this correlation, the iodine binding property of amylopectin internal chains was investigated as an indirect evidence of their abili...

High-performance anion-exchange chromatography was used to study the unit chain profiles of amylopectins and their φ,β-limit dextrins from two African rice (Oryza glaberrima) accessions—TOG 12440 and IRGC 103759. The samples were compared with two Asian rice (Oryza sativa) samples (cv Koshihi...

The development of glucose-responsive biopolymer nanocarriers for self-regulated insulin delivery is significant in the treatment of diabetes. In this work, for the first time, we have developed a new approach to prepare glucose-responsive biopolymer nanoparticles co-assembled by concanavalin A ...

This study determined the relationship between waxy (high amylopectin) and high protein digestibility (HD) traits in sorghum and malting quality with the aim of replacing barley malt in arid, tropical regions. Eight sorghum lines with differing endosperm traits: waxy, heterowaxy, waxy-HD, non-wa...

Starch films are gaining attention as substitutes of synthetic polymers due to their biodegradability and low cost. Some ionic liquids have been postulated as alternatives to glycerol, one of the best starch plasticizers, due to their great capacity to form hydrogen bonds with starch and hence g...

Feruloyl amylopectin (FAP) was synthesized by the N,N′-carbonyldiimidazole (CDI) activation method, and the enzymatically cross-linked feruloyl amylopectin (CL-FAP) was prepared via catalysis of horseradish peroxidase (HRP) with the presence of hydrogen peroxide (H2O2). RP-HPLC-DAD/ESI-TOF-MS m...

The impact of diurnal photosynthetic activity on the fine structure of the amylopectin fraction of starch synthesized by normal barley (NBS) and waxy barley (WBS), the latter completely devoid of amylose biosynthesis, was determined following the cultivation under normal diurnal or constant ligh...

Microflotation experiments and zeta potential measurements of fluorapatite, wavellite, and turquoise with the use of alkyl amines and amylopectin were conducted. The highest floatability values were achieved in the presence of dodecylamine, exceeding the floatabilities with octylamine between 30...

Unit chain length distributions of amylopectin and its φ, β-limit dextrins, which reflect amylopectin internal structure from three maca starches, were determined by high-performance anion-exchange chromatography with pulsed amperometric detection after debranching, and the samples were compar...

The standard molar Gibbs energy of formation of monoclinic phase of Bi2MoO6 (s) was determined by measuring the equilibrium oxygen partial pressures in the Bi (l) - MoO2 (s) -Bi2MoO6 (s) phase field using solid electrolyte based emf cells and it is given by the following expression: ΔfGm°±0.9...

A SAR study on derivatives of 2-amino-1-benzyl-4,5-diphenyl-1H-pyrrole-3-carbonitrile 5a revealed that the 3-carbonitrile group, vicinal 4,5-diphenyl and N-benzyl side chains of the pyrrole are important for the inhibitory potencies of these compounds against members representing the three main ...

A variety of 1-benzyl-3-heterocyclic pyrazoles were rapidly assembled by a two-step N-benzylation/Suzuki coupling sequence. A one-pot variation of this sequence is demonstrated.

The report presents a first example of a regio- and stereospecific Lewis acid-catalyzed aminolysis of 1-benzyl-3,4-epoxypiperidine leading to trans-3-amino-1-benzylpiperidin-4-ols, in contrast with other Lewis acid-catalyzed reactions leading to trans-4-amino-1-benzylpiperidin-3-ols. The reactio...

We have disclosed a series of 1-benzyl-3-ketoindole derivatives acting as either positive or negative modulators of the human A2B adenosine receptor (A2B AR) depending on small differences in their side chain. The new compounds were designed taking into account structural similarities between AR...

The thermal behavior, solid and liquid heat capacities of the 1-benzyl-3-methylimidazolium, [Bzmim]+, based ionic liquid series with Cl−, PF6−, BF4−, CHF2CF2SO3− and NTf2− as anions were used to evaluate the effect of the insertion of an aromatic character (benzyl group) and the expected increas...

A silver-catalyzed [3+2+1] annulation of amidines with benzyl isocyanide toward 2,4-diaryl-1,3,5-triazines was developed. A variety of symmetrical and unsymmetrical products were obtained in moderate to good yields. This work also features an oxidant-free approach to 2,4-disubstituted triazines.

In CDCl3 solution, enantiopure (S)-1-benzyl-6-methylpiperazine-2,5-dione (S)-1a formed diastereomeric CO⋯H–N hydrogen-bonded associates with racemic (RS,Z)-1-benzyl-3-[(dimethylamino)methylidene]piperazine-2,5-diones 2a and 2b, (RS)-tert-butyl pyroglutamate (RS)-2c and (RS)-N-benzoylalanine met...