The viscoelastic properties of a new light-activated temporary denture soft lining material have been monitored in vitro using a force/distance probe. Its baseline behaviour was characteristic of an elastic material and its compliance considerably less than that of both a short-term and a long-t...

The purpose of this study was to characterize the deformation properties of a range of long-term denture soft lining materials using dynamic mechanical thermal analysis. Specimens were subjected to sinusoidal shear deformation at a frequency of 1 Hz and a strain of 64 microns peak to peak over a...

Objectives: This study was conducted to investigate the bonding properties of five lining materials to a denture base resin. Two hard (chemical-cured resin: Kooliner “Coe Labs, USA” and light-cured VLC resin: Triad “Dentsply, USA”) and three soft (chemical-cured resin: Express “Alcos,-USA”...

The deterioration of six commercial resilient denture lining materials immersed in seven groups of denture cleansers was investigated. Although the grades of deterioration of these soft liners were not related to the amount of peroxide content or the pH of denture cleansers, the effects of perox...

Data on the wettability of long-term resilient denture base lining materials have previously been obtained by static methods. This study determined the dynamic contact angle of a range of long-term resilient lining materials and the surface free energy properties of these materials. This method ...

Objectives: The purpose of the study was to examine and describe the deformation behaviour of five denture soft lining materials under dynamic cyclic loading over a range of applied forces using apparatus designed to simulate masticatory performance.Methods: Five lining materials were tested ove...

ObjectivesTo evaluate the in vitro growth inhibition of Candida albicans, the rate of chlorhexidine release and shore A hardness from resins-based denture soft lining materials modified by chlorhexidine diacetate (CDA) or chlorhexidine hydrochloride (CHC) incorporation.

ObjectivesSoft denture lining materials show varied and changeable stress relaxation property and softness under cyclic loading conditions. The purpose of this study was to determine the changes in the stress relaxation property and the softness of commercial soft lining materials after cyclic l...

Denture soft lining materials are widely used in prosthetic dentistry. Their success has been attributed to their softness and resilience, properties described by their viscoelasticity. Though these properties have been extensively investigated in laboratory studies, clinical studies have been l...

The synthesis of a variety of novel benzisoxazolo[2,3-a]pyridinium tetrafluoroborates is described. These compounds are conveniently prepared from pyridine N-oxide via a microwave-promoted palladium-catalyzed direct arylation of pyridine N-oxide with 2-bromoacetanilides to give 2-(2-acetamidoary...

Polyhedral oligomeric silsesquioxane (POSS) was successfully applied, for the first time, to prepare imprinted monolithic column with high porosity and good permeability. The imprinted monolithic column was synthesized with a mixture of PSS-(1-Propylmethacrylate)-heptaisobutyl substituted (MA 07...

A library of 1,2- cyclometalated Pt(II) complexes based on various bidentate N,C-chelate chromophores have been studied for their uses as luminescent oxygen sensing probes (OSPs). The bidentate chelate ligands have been found to have a distinct impact on the performance of the Pt(II) compounds a...

The reaction of 4-(4-chlorophenyl)-2-mercapto-6-oxo-1,6-dihydropyrimidine-5-carbonitrile 1 with benzylidenemalononitrile and/or methyl iodide has yielded dihydropyrimido[1,2-a]pyrimidine derivative 5 and methylthio derivative 6 respectively. Thiated product 7 was cyclized with chloroacetonitrile...

10,11-Dihydro-11-[bis(methylthio)methylene]dibenzoxepin-10-one has been shown to be a useful three carbon synthon for the efficient regiospecific annulation of a variety of five- (pyrazoles, isoxazoles, thiophene, and γ-lactone) and six-membered (pyrimidines, pyridone and pyridines) heterocycle...

The chemistry of pyrimidines and their benzo derivatives, including quinazolines, perimidines and benzo[gh]perimidines is reviewed in this chapter, with particular attention paid to work published between 1996 and 2007, which covers the period since the publication of the second edition of Compr...

Pyrazolopyrimidines are the fused heterocyclic ring systems which structurally resemble purines which prompted biological investigations to assess their potential therapeutic significance. They are known to play a crucial role in numerous disease conditions. The advent of their first bioactivity...

The cyclin-dependent kinases (CDKs) play a crucial role in cell cycle progression and are validated targets of cancer therapy. Pyrazolopyrimidines are versatile scaffolds, which have been exploited for developing potential anticancer agents. We herein report the synthesis and in vitro CDK2/cycli...

New 5-aminopyrazoles 2a–c were prepared in high yields from the reaction of known α,α-dicyanoketene-N,S-acetals 1a–c with hydrazine hydrate under reflux in ethanol. These compounds were utilized as intermediates to synthesize pyrazolo[1,5-a]-pyrimidines 3a–c, 4a–d, 5a–c, and 6a–c, as wel...

Pyrazolo[3,4-d]pyrimidine ring system constitute an important class of heterocyclic compounds which can serve as a promising scaffold exhibiting many pharmacological activities. This ring system received much attention as it is a purine isostere by replacing imidazole ring in purine with pyrazol...

The reference standard N-(3-(4-methylpiperazin-1-yl)−1-(5-methylpyridin-2-yl)−1H-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide (9) and its demethylated precursor N-(1-(5-methylpyridin-2-yl)−3-(piperazin-1-yl)−1H-pyrazol-5-yl)pyrazolo[1,5-α]pyrimidine-3-carboxamide (8) were synthesized fr...