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Cas:461-96-1
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inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
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inquiryFactory supply 1-Bromo-3,5-difluorobenzene CAS 461-96-1 with fast delivery Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food
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inquiryhigh quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Product description: Product name 1-Bromo-3,5-difluorobenzene CAS number 461-96-1 Assay ≥99% Appearance Colorless transparent liquid Capacity 200mt/year Application Pharmaceu
Cas:461-96-1
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryDayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
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Cas:461-96-1
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu
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inquiryName: 1-Bromo-3,5-difluorobenzene Molecular Formula:C6H3BrF2 Molecular Weight:192.99 CAS No.:461-96-1 Appearance:Colorless To Slight Yellow Clear Liquid Appearance:Colorless To Slight Yellow Clear Liquid Storage: Preserve in well-closed, light
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inquiry1-Bromo-3,5-difluorobenzene Basic information Product Name: 1-Bromo-3,5-difluorobenzene Synonyms: 1-Bromo-3,5-difluorobenzene,99%;1-BROMO-3,5-DIFLUOROBENZENE;3,5-DIFLUOROBROMOBENZENE;1-Bromo-3,5-difluorobenzene,98% [3,5-Difluorobromobenzene];3,
Cas:461-96-1
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inquiry1-Bromo-3,5-difluorobenzene CAS:461-96-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic
Cas:461-96-1
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Cas:461-96-1
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inquiryProduct Detail Minimum Order Qty. 10 Gram
Cas:461-96-1
Min.Order:10 Gram
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryAppearance:off-white to white solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:As customer request Port:Qingda
Cas:461-96-1
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inquiry1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie
Cas:461-96-1
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
Cas:461-96-1
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryA substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc
Cas:461-96-1
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inquiry(4-bromo-2,6-difluorophenyl)triethylsilane
3,5-difluorobromobenzene
Conditions | Yield |
---|---|
With potassium fluoride In tetrahydrofuran; water for 2h; Heating; | 93% |
hypophosphorous acid
2-bromo-4,6-difluoroaniline hydrobromide
3,5-difluorobromobenzene
Conditions | Yield |
---|---|
With sodium nitrite In hydrogenchloride | 75% |
Conditions | Yield |
---|---|
Stage #1: 1,3-dibromo-5-fluorobenzene With TurboGrignard In tetrahydrofuran; 1,4-dioxane at 0 - 25℃; Inert atmosphere; Stage #2: With N-fluorobis(benzenesulfon)imide In dichloromethane; octadecafluorodecahydronaphthalene (cis+trans) at -78 - 20℃; Inert atmosphere; | 66% |
Stage #1: 1,3-dibromo-5-fluorobenzene With TurboGrignard In tetrahydrofuran at 25℃; Inert atmosphere; Stage #2: With N-fluorobis(benzenesulfon)imide In dichloromethane; octadecafluorodecahydronaphthalene (cis+trans) at -78 - 25℃; Inert atmosphere; | 66 %Chromat. |
3,5-difluorobromobenzene
Conditions | Yield |
---|---|
With hypophosphoric acid |
1,3-Difluorobenzene
A
3,5-difluorobromobenzene
B
1,4 - dibromo-2,6-difluorobenzene
1,3-Difluoro-1,2,3,4,5,6-hexabromocyclohexane
D
2,4,5-Tribromo-1,3-difluorobenzene
Conditions | Yield |
---|---|
With bromine In trichlorofluoromethane Irradiation; Further byproducts given. Yields of byproduct given; | A n/a B n/a C 2.01 g D n/a |
2-bromo-4,6-difluoroaniline hydrobromide
3,5-difluorobromobenzene
Conditions | Yield |
---|---|
With sodium hypophosphite; hydrogen bromide; sodium nitrite Yield given. Multistep reaction; | |
With hydrogenchloride; hypophosphorous acid; sodium nitrite 1.) water, 5 deg C, 2.) water, 0 deg C, 3 h; Yield given. Multistep reaction; |
Conditions | Yield |
---|---|
Substitution; Sandmeyer reaction; |
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 89 percent / butyllithium / hexane; tetrahydrofuran / -75 °C 2: 92 percent / sec-butyllithium; bromine / cyclohexane; tetrahydrofuran / 0.75 h 3: 82 percent / diisopropylamine; butyllithium / hexane; tetrahydrofuran / -75 °C 4: diisopropylamine; butyllithium / hexane; tetrahydrofuran / 2 h / -75 °C 5: 59 percent / butyllithium / diethyl ether; hexane / 0.25 h / -100 °C 6: 93 percent / potassium fluoride / tetrahydrofuran; H2O / 2 h / Heating View Scheme |
1-triethylsilyl-2,6-difluorobenzene
3,5-difluorobromobenzene
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 92 percent / sec-butyllithium; bromine / cyclohexane; tetrahydrofuran / 0.75 h 2: 82 percent / diisopropylamine; butyllithium / hexane; tetrahydrofuran / -75 °C 3: diisopropylamine; butyllithium / hexane; tetrahydrofuran / 2 h / -75 °C 4: 59 percent / butyllithium / diethyl ether; hexane / 0.25 h / -100 °C 5: 93 percent / potassium fluoride / tetrahydrofuran; H2O / 2 h / Heating View Scheme |
(3-bromo-2,6-difluorophenyl)triethylsilane
3,5-difluorobromobenzene
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 82 percent / diisopropylamine; butyllithium / hexane; tetrahydrofuran / -75 °C 2: diisopropylamine; butyllithium / hexane; tetrahydrofuran / 2 h / -75 °C 3: 59 percent / butyllithium / diethyl ether; hexane / 0.25 h / -100 °C 4: 93 percent / potassium fluoride / tetrahydrofuran; H2O / 2 h / Heating View Scheme |
(3,4-dibromo-2,6-difluorophenyl)triethylsilane
3,5-difluorobromobenzene
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 59 percent / butyllithium / diethyl ether; hexane / 0.25 h / -100 °C 2: 93 percent / potassium fluoride / tetrahydrofuran; H2O / 2 h / Heating View Scheme |
(3,5-dibromo-2,6-difluorophenyl)triethylsilane
3,5-difluorobromobenzene
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: diisopropylamine; butyllithium / hexane; tetrahydrofuran / 2 h / -75 °C 2: 59 percent / butyllithium / diethyl ether; hexane / 0.25 h / -100 °C 3: 93 percent / potassium fluoride / tetrahydrofuran; H2O / 2 h / Heating View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 91 percent / Br2 / acetic acid / 0.25 h / Ambient temperature 2: 1.) 12 N HCl, NaNO2, 2.) 50 percent H3PO2 / 1.) water, 5 deg C, 2.) water, 0 deg C, 3 h View Scheme | |
Multi-step reaction with 2 steps 1: 88 percent / Br2, acetic acid 2: 1.) NaNO2, HBr, 2.) NaH2PO2*xH2O View Scheme |
2-bromo-4,6-difluoroaniline
copper(I) oxide
3,5-difluorobromobenzene
Conditions | Yield |
---|---|
With ammonium hydroxide |
3,5-difluorobromobenzene
Conditions | Yield |
---|---|
Stage #1: 2-bromo-4,6-difluoroaniline hydrochloride With sodium nitrite In water at 0 - 5℃; for 1h; Green chemistry; Stage #2: With sodium hypophosphite In water for 2h; Green chemistry; | 190.9 g |
chloro-trimethyl-silane
3,5-difluorobromobenzene
(4-bromo-2,6-difluoro-phenyl)-trimethyl-silane
Conditions | Yield |
---|---|
Stage #1: 3,5-difluorobromobenzene With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -100 - -90℃; for 2h; Stage #2: chloro-trimethyl-silane In tetrahydrofuran; hexane at -85℃; | 100% |
Stage #1: 3,5-difluorobromobenzene With n-butyllithium; diisopropylamine In tetrahydrofuran at -100 - -90℃; for 2.33333h; Stage #2: chloro-trimethyl-silane In tetrahydrofuran at -100 - 20℃; | 100% |
With n-butyllithium In tetrahydrofuran; hexane at -75℃; | 93% |
Stage #1: 3,5-difluorobromobenzene With n-butyllithium; diisopropylamine In tetrahydrofuran at -100℃; for 2h; Stage #2: chloro-trimethyl-silane In tetrahydrofuran at -100 - 20℃; for 16h; |
3,5-difluorobromobenzene
1-t-Butoxycarbonylpiperazine
tert-butyl 4-(3,5-difluorophenyl)piperazine-1-carboxylate
Conditions | Yield |
---|---|
Stage #1: 3,5-difluorobromobenzene; 1-t-Butoxycarbonylpiperazine With tri-tert-butyl phosphine; palladium diacetate; sodium t-butanolate In xylene at 50℃; Stage #2: With macroporous polymer-supported isocyanate In xylene at 50℃; for 24h; | 100% |
With tris-(dibenzylideneacetone)dipalladium(0); johnphos; sodium t-butanolate In toluene for 15h; Inert atmosphere; Reflux; | 100% |
With tris-(dibenzylideneacetone)dipalladium(0); johnphos; sodium t-butanolate In toluene for 15.5h; Time; Inert atmosphere; Reflux; | 100% |
With Quinuclidine; nickel(II) bromide trihydrate In N,N-dimethyl acetamide at 20℃; for 3h; Sealed tube; Irradiation; Inert atmosphere; | 62% |
Conditions | Yield |
---|---|
Stage #1: 3,5-difluorobromobenzene With dichloro [1,1'-bis(diphenylphosphino)propane]palladium(II) In tetrahydrofuran for 0.0833333h; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique; Stage #2: cyclohexylmagnesium bromide With lithium bromide In tetrahydrofuran at 20℃; for 24h; Reagent/catalyst; Inert atmosphere; Schlenk technique; | 100% |
Conditions | Yield |
---|---|
With bis(η3-allyl-μ-chloropalladium(II)); 5-(di(adamantan-1-yl)phosphino)-1′,3′,5′-triphenyl-1′H-1,4′-bipyrazole; potassium phenolate In 1,4-dioxane at 100℃; for 6h; Sealed tube; Inert atmosphere; | 100% |
3,5-difluorobromobenzene
bis(pinacol)diborane
Conditions | Yield |
---|---|
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1-(4,4'-di-tert-butyl-[2,2'-bipyridin]-6-yl)-2-(dimethyl(phenyl)silyl)-2,3-dihydro-1H-benzo[d][1,3,2]diazaborole at 140℃; for 12h; Inert atmosphere; Schlenk technique; Sealed tube; | 99% |
With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; cyclopentyl methyl ether; 1,1'-di(pyridin-2-yl)-1,1',3,3'-tetrahydro-2,2'-bibenzo[d][1,3,2]diazaborole at 100℃; for 16h; Schlenk technique; Inert atmosphere; | 87% |
With (1,5-cyclooctadiene)(methoxy)iridium(l) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine In tetrahydrofuran at 80℃; for 24h; Inert atmosphere; |
bis[(trimethylsilyl)methyl](1,5-cyclooctadiene)palladium(II)
3,5-difluorobromobenzene
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 1h; | 99% |
3,5-difluorobromobenzene
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; ruphos In tert-butyl alcohol at 110℃; Buchwald-Hartwig Coupling; Inert atmosphere; Sealed tube; | 99% |
3,5-difluorobromobenzene
benzyl alcohol
5-benzyloxy-3-fluorophenyl bromide
Conditions | Yield |
---|---|
Stage #1: benzyl alcohol With sodium hydride In tetrahydrofuran for 1h; Stage #2: 3,5-difluorobromobenzene In tetrahydrofuran at 20℃; for 49h; | 98% |
Stage #1: benzyl alcohol With sodium hydride In tetrahydrofuran for 1h; Stage #2: 3,5-difluorobromobenzene In tetrahydrofuran at 20℃; for 49h; | 98% |
Stage #1: benzyl alcohol With sodium hydride In tetrahydrofuran; mineral oil for 1h; Stage #2: 3,5-difluorobromobenzene In tetrahydrofuran; mineral oil at 20 - 40℃; | 82% |
3,5-difluorobromobenzene
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); tetrabutylammomium bromide; potassium carbonate In ethanol; water at 40 - 72℃; for 4h; Inert atmosphere; | 98% |
3,5-difluorobromobenzene
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); tetrabutylammomium bromide; potassium carbonate In ethanol; water at 40 - 72℃; Inert atmosphere; | 98% |
3,5-difluorobromobenzene
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); tetrabutylammomium bromide; potassium carbonate In ethanol; water at 40 - 72℃; for 4h; Inert atmosphere; | 98% |
Conditions | Yield |
---|---|
With potassium carbonate; butan-1-ol; palladium diacetate; triphenylphosphine at 100℃; for 1h; | 97% |
With N,N,N,N,-tetramethylethylenediamine; C41H40IrN6 In acetonitrile at 45℃; for 48h; Sealed tube; Glovebox; Inert atmosphere; | 52% |
With 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzo[d]imidazole; C39H45IrN4 In N,N-dimethyl-formamide at 45℃; for 24h; Reagent/catalyst; Irradiation; Glovebox; | 97 %Spectr. |
carbon dioxide
3,5-difluorobromobenzene
4-bromo-2,6-difluorobenzoic acid
Conditions | Yield |
---|---|
With 2,2,6,6-tetramethyl-piperidine; n-butyllithium In tetrahydrofuran; hexane at -75℃; for 2h; | 96% |
Stage #1: 3,5-difluorobromobenzene With lithium diisopropyl amide In tetrahydrofuran; hexane at -78℃; for 2h; Stage #2: carbon dioxide In tetrahydrofuran; hexane at -78℃; under 150.012 Torr; for 0.5h; | 86.8% |
Stage #1: 3,5-difluorobromobenzene With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 1.75h; Stage #2: carbon dioxide at 20℃; for 16h; | 84% |
3,5-difluorobromobenzene
[2-(3,5-difluorophenyl)ethynyl]trimethylsilane
Conditions | Yield |
---|---|
96% |
3,5-difluorobromobenzene
ethyl 2-(dimethyl(oxo)-λ6-sulfaneylidene)acetate
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In acetonitrile at 80℃; for 15h; Inert atmosphere; Schlenk technique; Sealed tube; | 96% |
3,5-difluorobromobenzene
2-(3-fluoro-4-trimethylsilylphenyl)-5,5-dimethyl[1,3,2]dioxaborinane
3,3',5'-trifluoro-4-trimethylsilylbiphenyl
Conditions | Yield |
---|---|
With potassium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane Suzuki coupling; Heating; | 95% |
Conditions | Yield |
---|---|
With nickel(II) fluoride; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride In tetrahydrofuran at 0 - 40℃; for 18.5h; Inert atmosphere; | 95% |
3,5-difluorobromobenzene
2-[2-(trimethylsilyl)ethynyl]benzaldehyde
(3,5-difluorophenyl)(2-((trimethylsilyl)ethynyl)phenyl)methanol
Conditions | Yield |
---|---|
Stage #1: 3,5-difluorobromobenzene With iodine; magnesium Stage #2: 2-[2-(trimethylsilyl)ethynyl]benzaldehyde In tetrahydrofuran at -78 - 20℃; for 1h; | 95% |
3,5-difluorobromobenzene
2-hydroxy-2-methylpropanenitrile
3,5-difluorobenzonitrile
Conditions | Yield |
---|---|
Stage #1: 3,5-difluorobromobenzene With copper(l) iodide; 1,10-Phenanthroline; potassium iodide In N,N-dimethyl-formamide at 110℃; for 6h; Stage #2: 2-hydroxy-2-methylpropanenitrile With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 110℃; for 60h; | 94% |
3,5-difluorobromobenzene
3-bromo-5-fluorophenol
Conditions | Yield |
---|---|
Stage #1: 3,5-difluorobromobenzene With 2-(methylsulfonyl)ethyl alcohol; potassium tert-butylate In dimethyl sulfoxide at 0 - 20℃; for 3h; Stage #2: With hydrogenchloride In water; dimethyl sulfoxide pH=1; Stage #3: With sodium hydroxide In diethyl ether; water | 94% |
Stage #1: 3,5-difluorobromobenzene With potassium trimethylsilonate In diethylene glycol dimethyl ether at 120℃; for 5h; Inert atmosphere; Stage #2: With hydrogenchloride In diethylene glycol dimethyl ether; water at 20℃; Inert atmosphere; | 92% |
With potassium trimethylsilonate In diethylene glycol dimethyl ether at 120℃; for 5h; Inert atmosphere; | 92% |
Conditions | Yield |
---|---|
With copper(I) oxide; 1-D-O-Methyl-chiro-inositol; ammonia; sodium hydroxide In water at 100℃; for 12h; | 94% |
With copper(I) oxide; ammonium hydroxide at 120℃; for 6h; Reagent/catalyst; Temperature; Autoclave; Green chemistry; | 85% |
3,5-difluorobromobenzene
2-bromo-3-(4-(methylthio)phenyl)-2-cyclopenten-1-one
2-(3',5'-difluorophenyl)-3-(4'-methylthiophenyl)cyclopent-2-en-1-one
Conditions | Yield |
---|---|
Stage #1: With n-butyllithium In hexane at -78℃; for 0.5h; Metallation; Stage #2: With Triisopropyl borate In hexane Substitution; Suzuki coupling; Stage #3: 3,5-difluorobromobenzene; 2-bromo-3-(4-(methylthio)phenyl)-2-cyclopenten-1-one With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride In water; toluene Substitution; Suzuki coupling; Heating; | 93% |
tetrahydrofuran
3,5-difluorobromobenzene
2-(3,5-difluorophenyl)tetrahydrofuran
Conditions | Yield |
---|---|
Stage #1: tetrahydrofuran; 3,5-difluorobromobenzene With iodine; magnesium at 0 - 20℃; for 1h; Inert atmosphere; Stage #2: With iron(III) oxide In tetrahydrofuran at 0 - 20℃; for 5h; Inert atmosphere; | 93% |
Stage #1: 3,5-difluorobromobenzene With iodine; magnesium In tetrahydrofuran at 0 - 20℃; Inert atmosphere; Stage #2: tetrahydrofuran With iron(III) oxide at 0 - 20℃; for 5h; Inert atmosphere; | 92.84% |
3,5-difluorobromobenzene
9H-carbazole
9,9’-(5-bromo-1,3-phenylene)bis(9H-carbazole)
Conditions | Yield |
---|---|
Stage #1: 9H-carbazole With potassium tert-butylate at 120 - 140℃; Stage #2: 3,5-difluorobromobenzene for 2h; | 93% |
Stage #1: 9H-carbazole With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 1h; Stage #2: 3,5-difluorobromobenzene In N,N-dimethyl-formamide; mineral oil at 130℃; for 12h; Cooling with ice; | 92% |
With caesium carbonate In N,N-dimethyl-formamide at 170℃; for 15h; | 91% |
3,5-difluorobromobenzene
(S)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene at 80℃; for 3.5h; Inert atmosphere; Reflux; | 93% |
With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene at 110℃; for 2.5h; Inert atmosphere; |
3,5-difluorobromobenzene
3,6-di(tert-butyl)-9H-carbazole
Conditions | Yield |
---|---|
Stage #1: 3,6-di(tert-butyl)-9H-carbazole With 1,3-dimethyl-2-imidazolidinone; potassium tert-butylate at 120℃; Stage #2: 3,5-difluorobromobenzene at 150℃; for 1h; Inert atmosphere; | 93% |
Stage #1: 3,6-di(tert-butyl)-9H-carbazole With sodium hydride In N,N-dimethyl-formamide for 0.5h; Stage #2: 3,5-difluorobromobenzene In N,N-dimethyl-formamide for 16h; Reflux; | 80.4% |
With sodium hydride In N,N-dimethyl-formamide Reflux; | 79.1% |
With caesium carbonate In N,N-dimethyl-formamide at 60℃; for 24h; | |
With caesium carbonate In N,N-dimethyl-formamide at 120℃; Inert atmosphere; | 59.9 g |
3,5-difluorobromobenzene
trimethylsilylacetylene
[2-(3,5-difluorophenyl)ethynyl]trimethylsilane
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In acetonitrile at 120℃; for 0.0833333h; Sonogashira Cross-Coupling; Microwave irradiation; Sealed tube; Inert atmosphere; | 92% |
With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); diethylamine In N,N-dimethyl-formamide at 120℃; for 0.25h; Inert atmosphere; | 90% |
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In acetonitrile at 100℃; for 16h; Inert atmosphere; Sealed tube; | 80% |
With copper(l) iodide; diisopropylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride | |
With copper(l) iodide; triethylamine; tetrakis(triphenylphosphine) palladium(0) Heating; |
Conditions | Yield |
---|---|
92% |
3,5-difluorobromobenzene
phenol
((5-bromo-1,3-phenylene)bis(oxy))dibenzene
Conditions | Yield |
---|---|
With caesium carbonate In 1-methyl-pyrrolidin-2-one at 120℃; for 18h; Inert atmosphere; | 92% |
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 170℃; for 10h; Inert atmosphere; | 35.9 g |
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 170℃; for 10h; Inert atmosphere; | 35.9 g |
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 150℃; for 48h; Inert atmosphere; | 119 g |
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 150℃; for 48h; Inert atmosphere; | 119 g |
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