English Name: Temozolomide Chinese Name: Temozolomide CAS NO. : 85622-93-1 Properties: White or light pink crystalline powder. Slightly soluble in water, soluble in hot water. Quality standard: National standard;USP;any impurity<0.1% total impu
Shenzhen Foris Technology Co.LTD is located in Shenzhen ,Guangdong, is the leading supplier for electronic chemicals,APIs, pharmaceutical intermediates, fine chemicals which can be widely used in semiconductor, petrochemical industry, new materials
Cas:85622-93-1
Min.Order:1 Kilogram
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inquiryDayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
Cas:85622-93-1
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryLIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.
Cas:85622-93-1
Min.Order:1 Kilogram
FOB Price: $0.8 / 1.0
Type:Lab/Research institutions
inquiryJinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu
Cas:85622-93-1
Min.Order:1 Gram
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Type:Manufacturers
inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:85622-93-1
Min.Order:1 Metric Ton
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inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White Crystalline Powder Storage:2-8°C Package:1kg/foil b
Cas:85622-93-1
Min.Order:1 Kilogram
FOB Price: $1800.0 / 2500.0
Type:Trading Company
inquiryWe are manufacture for the materials, and other sarms,steriods ,we also produce, price is very competitive, quality very good. Appearance:white powder Application:Pharmaceutical
Cas:85622-93-1
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inquiryTemozolomide CAS No.:85622-93-1 Name: Temozolomide Synonyms: 4-Methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-triene-9-carboxamide Molecular Structure Molecular Formula: C6H6N6O2 Molecular Weight
Cas:85622-93-1
Min.Order:1 Kilogram
FOB Price: $2.0
Type:Other
inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:85622-93-1
Min.Order:1 Gram
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Type:Manufacturers
inquiryADVANTAGE: 1. More than 3,000 Chinese medicine reference substances / standard products available from stock, issued on the same day, multiple cities can be delivered the next day 2. The products are provided with COA, HPLC, NMR, quality assurance,
Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:85622-93-1
Min.Order:1 Kilogram
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Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c
Cas:85622-93-1
Min.Order:1 Kilogram
FOB Price: $100.0
Type:Trading Company
inquiryName:Temozolomide CAS:85622-93-1 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability
Cas:85622-93-1
Min.Order:25 Kilogram
FOB Price: $1.0 / 2.0
Type:Other
inquiryProduct Name: Temozolomide Synonyms: 4-methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-triene-9-carboxamide;TEMOZOLOMIDE;1-d)(1,2,3,5)tetrazine-8-carboxamide,3,4-dihydro-3-methyl-4-oxo-imidazo(;3,4-dihydro-3-methyl-4-oxoimidazo(
Cas:85622-93-1
Min.Order:1 Gram
FOB Price: $8900.0
Type:Lab/Research institutions
inquiryOur advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva
Cas:85622-93-1
Min.Order:1 Kilogram
FOB Price: $9.0 / 99.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:85622-93-1
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Type:Trading Company
inquiryTemozolomide Supplier CAS:85622-93-1 Molecularformula: C6H6N6O2 Purity: 99% min Appearance: White or light yellow powder Appearance:White powder Storage:RT. Package:25kg bag Application:Metabolism Drug; Carcino-Chemotherapeutic Drug;Anti
Appearance:Off-white to light-pink crystalline solid Storage:Room temperature Package:1kg/bag Application:Antitumor Transportation:Express/Sea/Air Port:Any port in china
Cas:85622-93-1
Min.Order:100 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Powder Storage:Store in sealed containers at cool & dr
Cas:85622-93-1
Min.Order:100 Gram
Negotiable
Type:Other
inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
Cas:85622-93-1
Min.Order:1 Kilogram
FOB Price: $200.0 / 400.0
Type:Trading Company
inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem (China) Co.,Ltd is Sp
Cas:85622-93-1
Min.Order:100 Gram
FOB Price: $1.0
Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:85622-93-1
Min.Order:10 Gram
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Type:Trading Company
inquiryProduct Name: Temozolomide Synonyms: 4-methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-triene-9-carboxamide;TEMOZOLOMIDE;methazolastone;nsc362856;temodar;Temozolamide;Temozolimide;3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazin
Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:85622-93-1
Min.Order:1 Kilogram
FOB Price: $186.0 / 210.0
Type:Trading Company
inquiryTemozolomide CAS:85622-93-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediate
Cas:85622-93-1
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi
Cas:85622-93-1
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryConditions | Yield |
---|---|
In dichloromethane at 25℃; for 480h; | 98% |
In 1,4-dioxane at 50℃; | 76.5% |
In dimethyl sulfoxide at 25℃; |
temozolomide
Conditions | Yield |
---|---|
With ammonium hydroxide; copper(II) sulfate at 100℃; for 6h; Reagent/catalyst; Temperature; | 92% |
temozolomide
Conditions | Yield |
---|---|
With Lewatit Mono Plus MP-64 In acetone at 60 - 63℃; styrene-divinylbenzene (macroporous); Purification / work up; | 90.3% |
With acetic acid In water; acetone for 0.166667h; Purification / work up; Heating / reflux; | 88% |
With acetic acid In water; acetonitrile at 60 - 63℃; for 0.166667h; Purification / work up; | 86.7% |
With acetic acid In tetrahydrofuran; water for 0.166667h; Purification / work up; Heating / reflux; | 70% |
temozolomide
Conditions | Yield |
---|---|
In methanol; acetone at 20℃; for 1h; UV-irradiation; | 79% |
temozolomide
Conditions | Yield |
---|---|
With tetrabutyl ammonium fluoride In acetic acid; acetonitrile at 25℃; for 24h; | 78% |
With tetrabutyl ammonium fluoride; acetic acid In acetonitrile at 25℃; | 78% |
5-amino-N1-methyl-1H-imidazole-1,4-dicarboxamide
temozolomide
Conditions | Yield |
---|---|
Stage #1: 5-amino-N1-methyl-1H-imidazole-1,4-dicarboxamide With lithium chloride hydrate; acetic acid In water at 20℃; for 0.5h; Stage #2: With iodine; sodium nitrite In water at -10 - 20℃; for 3h; | 76% |
Stage #1: 5-amino-N1-methyl-1H-imidazole-1,4-dicarboxamide With acetic acid; lithium bromide In water at 20℃; for 1h; Stage #2: With sodium nitrite In water at -10 - 20℃; for 6h; Stage #3: With sodium thiosulfate In water for 0.333333h; Product distribution / selectivity; | 64% |
Stage #1: 5-amino-N1-methyl-1H-imidazole-1,4-dicarboxamide With sodium nitrite In water at 0℃; for 0.333333h; Stage #2: With tartaric acid In water at 0 - 60℃; for 4h; | 47% |
N-tert-butyl-3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
temozolomide
Conditions | Yield |
---|---|
With sulfuric acid at 15 - 20℃; for 3h; | 52% |
5-amino-N1-methyl-1H-imidazole-1,4-dicarboxamide
A
temozolomide
B
2-Azahypoxanthine
Conditions | Yield |
---|---|
With hydrogenchloride; sodium nitrite at 5 - 25℃; | A 35% B 15% |
Conditions | Yield |
---|---|
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile | 22% |
With 1,8-diazabicyclo[5.4.0]undec-7-ene In acetonitrile at 25℃; | 22% |
(8-Carbamoyl-4-oxo-imidazo[5,1-d][1,2,3,5]tetrazin-3-yl)-acetic acid 2-thioxo-2H-pyridin-1-yl ester
temozolomide
Conditions | Yield |
---|---|
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In N,N-dimethyl-formamide at 25℃; Irradiation; Yield given; | |
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In N,N-dimethyl-formamide for 0.5h; Ambient temperature; Irradiation; Yield given; |
dimethyl sulfate
temozolomide
Conditions | Yield |
---|---|
With triethylamine In dimethyl sulfoxide at 25℃; Yield given; |
5-amino-N1-methyl-1H-imidazole-1,4-dicarboxamide
A
temozolomide
Conditions | Yield |
---|---|
With tartaric acid; sodium nitrite In water at 0℃; for 1h; | A 45 % Chromat. B n/a |
temozolomide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 74 percent / aq. HCl / acetic acid / 0.42 h / Heating 2: 79 percent / acetone; methanol / 1 h / 20 °C / UV-irradiation View Scheme |
C17H18N6O3
temozolomide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 2.05 g / TFA / acetic acid; methanol / 5 h / 20 °C 2: 74 percent / aq. HCl / acetic acid / 0.42 h / Heating 3: 79 percent / acetone; methanol / 1 h / 20 °C / UV-irradiation View Scheme |
5-Amino-4-carbamoyl-imidazole-1-carboxylic acid 4-nitro-phenyl ester
temozolomide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 48 percent / tetrahydrofuran; ethanol / 25 °C 2: 45 percent Chromat. / NaNO2, tartaric acid / H2O / 1 h / 0 °C View Scheme |
8-carbamoyl-3,4-dihydro-4-oxoimidazo<5,1-d>-1,2,3,5-tetrazin-3-ylacetic acid
temozolomide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: N-methylmorpholine / dimethylformamide / 0.17 h / -15 - -10 °C 2: Et3N / dimethylformamide / 0.5 h / -15 - -10 °C 3: AIBN, Bu3SnH / dimethylformamide / 0.5 h / Ambient temperature; Irradiation View Scheme | |
Multi-step reaction with 3 steps 1: N-methylmorpholine / dimethylformamide / -15 °C 2: Et3N / -15 °C 3: Bu3SnH, AIBN / dimethylformamide / 25 °C / Irradiation View Scheme |
ethyl (8-carbamoyl-3,4-dihydro-4-oxoimidazo<5,1-d>-1,2,3,5-tetrazin-3-yl)acetate
temozolomide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 80 percent / aq. HCl / 4 h / 40 - 45 °C 2: N-methylmorpholine / dimethylformamide / 0.17 h / -15 - -10 °C 3: Et3N / dimethylformamide / 0.5 h / -15 - -10 °C 4: AIBN, Bu3SnH / dimethylformamide / 0.5 h / Ambient temperature; Irradiation View Scheme | |
Multi-step reaction with 4 steps 1: 80 percent / 5M aq. HCl / 45 °C 2: N-methylmorpholine / dimethylformamide / -15 °C 3: Et3N / -15 °C 4: Bu3SnH, AIBN / dimethylformamide / 25 °C / Irradiation View Scheme |
C12H14N6O6
temozolomide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Et3N / dimethylformamide / 0.5 h / -15 - -10 °C 2: AIBN, Bu3SnH / dimethylformamide / 0.5 h / Ambient temperature; Irradiation View Scheme | |
Multi-step reaction with 2 steps 1: Et3N / -15 °C 2: Bu3SnH, AIBN / dimethylformamide / 25 °C / Irradiation View Scheme |
[(5-Amino-4-carbamoyl-imidazole-1-carbonyl)-amino]-acetic acid ethyl ester
temozolomide
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 93 percent / 2N aq. NCl, NaNO2 / 0 °C 2: 80 percent / 5M aq. HCl / 45 °C 3: N-methylmorpholine / dimethylformamide / -15 °C 4: Et3N / -15 °C 5: Bu3SnH, AIBN / dimethylformamide / 25 °C / Irradiation View Scheme |
5-amino-1H-imidazole-4-carboxamide monohydrochloride
4-Nitrophenyl chloroformate
temozolomide
Conditions | Yield |
---|---|
With triethylamine In dichloromethane |
methyl iodide
temozolomide
Conditions | Yield |
---|---|
Stage #1: 4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0℃; for 0.05h; Stage #2: methyl iodide In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 2.5h; | |
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 5h; |
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 20℃; for 72h; Industry scale; |
tert-butyl (8-carbamoyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazin-3(4H)-yl)methylcarbamate
temozolomide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogenchloride / water / 15 h / 4 - 20 °C / Darkness 2: sodium hydride / N,N-dimethyl-formamide / 5 h / 0 - 20 °C View Scheme |
temozolomide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: boron trifluoride diethyl etherate / chloroform / 2 h / 0 - 20 °C 2: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile View Scheme | |
Multi-step reaction with 2 steps 1: boron trifluoride / chloroform / 0 °C 2: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 25 °C View Scheme |
1,1'-carbonyldiimidazole
temozolomide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: acetonitrile; N,N-dimethyl-formamide / 2 h / 20 °C 2.1: acetonitrile / 6 h / 55 - 60 °C 3.1: sodium nitrite / water / 0.33 h / 0 °C 3.2: 4 h / 0 - 60 °C View Scheme |
temozolomide
3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrahydro-8-carboxylic acid
Conditions | Yield |
---|---|
With sulfuric acid; sodium nitrite | 100% |
With sulfuric acid; water; sodium nitrite at 15 - 20℃; | 98.6% |
With sulfuric acid; sodium nitrite In water at 0℃; | 80% |
temozolomide
methyl (Z)-2-((3R,4S,5S,8S,9S,10S,11R,13R,14S,16S)-16-acetoxy-3,11-dihydroxy-4,8,10,14-tetramethylhexadecahydro-17H-cyclopenta[a]phenanthren-17-ylidene)-6-methylhept-5-enoate
Conditions | Yield |
---|---|
With sodium carbonate In 1,4-dioxane; water at 60℃; for 6h; Sealed tube; | 97% |
temozolomide
telmisatran
4'-[[4-methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazol-1-yl]methyl]biphenyl-2-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With sodium carbonate In 1,4-dioxane; water at 60℃; for 6h; Sealed tube; | 95% |
Conditions | Yield |
---|---|
With sodium carbonate In 1,4-dioxane; water at 60℃; for 6h; Sealed tube; | 95% |
Conditions | Yield |
---|---|
In ethanol for 1h; | 94% |
[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
temozolomide
indomethacin methyl ester
Conditions | Yield |
---|---|
With sodium carbonate In 1,4-dioxane; water at 60℃; for 6h; Sealed tube; | 93% |
Conditions | Yield |
---|---|
With meso-tetraphenylporphyrin iron(III) chloride; potassium hydroxide In water at 23℃; for 4h; Sealed tube; | 93% |
Conditions | Yield |
---|---|
With meso-tetraphenylporphyrin iron(III) chloride; potassium hydroxide In water at 23℃; for 4h; Catalytic behavior; Reagent/catalyst; Solvent; Sealed tube; | 91% |
steviol
temozolomide
methyl (4R,4aS,6aR,9S,11aR,11bS)-9-hydroxy-4,11b-dimethyl-8-methylenetetradecahydro-6a,9-methanocyclohepta[a]naphthalene-4-carboxylate
Conditions | Yield |
---|---|
With sodium carbonate In 1,4-dioxane; water at 60℃; for 6h; Sealed tube; | 90% |
4-isopropylidene cyclohex-1-enyl methanol
temozolomide
Conditions | Yield |
---|---|
Stage #1: temozolomide With oxalyl dichloride In 1,2-dichloro-ethane at 10℃; for 3h; Swern Oxidation; Inert atmosphere; Reflux; Stage #2: 4-isopropylidene cyclohex-1-enyl methanol In 1,2-dichloro-ethane at 20℃; for 14h; Time; Reflux; | 89% |
Conditions | Yield |
---|---|
Stage #1: oxalyl dichloride; temozolomide In 1,2-dichloro-ethane at 20℃; for 3h; Inert atmosphere; Stage #2: (-)-perillyl alcohol In 1,2-dichloro-ethane at 20℃; for 14h; Inert atmosphere; | 89% |
androst-4-en-3-one-17β-carboxylic acid
temozolomide
3-oxo-androst-4-ene-17β-carboxylic acid methyl ester
Conditions | Yield |
---|---|
With sodium carbonate In 1,4-dioxane; water at 60℃; for 4h; Sealed tube; | 89% |
p-N,N-dimethylaminobenzoic acid
temozolomide
methyl 4-(N,N-dimethylamino)benzoate
Conditions | Yield |
---|---|
With sodium carbonate In 1,4-dioxane; water at 60℃; for 6h; Sealed tube; | 88% |
temozolomide
N,N'-di-tert-butyloxycarbonylpiperazine-2-carboxylic acid
O1,O4-di-tert-butyl O2-methyl piperazine-1,2,4-tricarboxylate
Conditions | Yield |
---|---|
With sodium carbonate In 1,4-dioxane; water at 60℃; for 6h; Sealed tube; | 88% |
2-(6-chloro-carbazol-2-yl)-propionic acid
temozolomide
methyl (2RS)-2-(6-chloro-9H-carbazol-2-yl)propanoate
Conditions | Yield |
---|---|
With sodium carbonate In 1,4-dioxane; water at 60℃; for 6h; Sealed tube; | 88% |
N-Fmoc L-Phe
temozolomide
methyl (((9H-fluoren-9-yl)methoxy)carbonyl)-L-phenylalaninate
Conditions | Yield |
---|---|
With sodium carbonate In 1,4-dioxane; water at 60℃; for 6h; Sealed tube; | 87% |
Conditions | Yield |
---|---|
With meso-tetraphenylporphyrin iron(III) chloride; potassium hydroxide In water at 23℃; for 4h; Sealed tube; | 87% |
Conditions | Yield |
---|---|
With sodium carbonate In 1,4-dioxane; water at 60℃; for 6h; Sealed tube; | 86% |
epigibberic acid
temozolomide
(4bR,7S,9aS,10R)-1,7-dimethyl-8-oxo-4b,6,7,8,9,10-hexahydro-5H-7,9a-methanobenzo[a]azulene-10-carboxylate
Conditions | Yield |
---|---|
With sodium carbonate In 1,4-dioxane; water at 60℃; for 6h; Sealed tube; | 86% |
temozolomide
3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester
tert-butyl (S)-3-(2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-methoxy-3-oxopropyl)-1H-indole-1-carboxylate
Conditions | Yield |
---|---|
With sodium carbonate In 1,4-dioxane; water at 60℃; for 6h; Sealed tube; | 85% |
temozolomide
3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carbothioamide
Conditions | Yield |
---|---|
With 2,4-(4-phenoxyphenyl)-1,3-dithia-2λ(5),4λ(5)-diphosphetane 2,4-disulfides In dichloromethane Reflux; | 84% |
With Lawessons reagent In dichloromethane Reflux; Inert atmosphere; | 80% |
Conditions | Yield |
---|---|
With sodium carbonate In 1,4-dioxane; water at 60℃; for 6h; Sealed tube; | 83% |
4-<(tetrahydropyran-2-yloxy)methyl>benzoic acid
temozolomide
methyl 4-<(tetrahydropyran-2-yloxy)methyl>benzoate
Conditions | Yield |
---|---|
With sodium carbonate In 1,4-dioxane; water at 60℃; for 4h; Sealed tube; | 83% |
4-Methoxyphenylacetic acid
temozolomide
4-methoxy-phenyl acetic acid methyl ester
Conditions | Yield |
---|---|
With sodium carbonate In 1,4-dioxane; water at 60℃; for 6h; Sealed tube; | 83% |
1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid
temozolomide
methyl 1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetate
Conditions | Yield |
---|---|
With sodium carbonate In 1,4-dioxane; water at 60℃; for 6h; Sealed tube; | 81% |
temozolomide
(1R,2S,4aR,4bR,7S,9aS,10S)-2,7-dihydroxy-1-methyl-8-methylene-13-oxo-1,2,4b,5,6,7,8,9,10,10a-decahydro-4a,1-(epoxymethano)-7,9a-methanobenzo[a]azulene-10-carboxylate
Conditions | Yield |
---|---|
With sodium carbonate In 1,4-dioxane; water at 60℃; for 6h; Sealed tube; | 81% |
Conditions | Yield |
---|---|
With sodium carbonate In 1,4-dioxane; water at 60℃; for 6h; Sealed tube; | 80% |
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