• Name

  1,2-Dibromo-4-fluorobenzene

• EINECS 219-131-1
• CAS No. 2369-37-1
• Density 2.015 g/cm³
• Solubility
• Melting Point 69 °C
• Formula C₆H₃Br₂F
• Boiling Point 219.7 °C at 760 mmHg
• Molecular Weight 253.896
• Flash Point 86.7 °C
• Transport Information
• Appearance Clear colourless to light yellow liquid
• Safety 26-36/37/39
• Risk Codes 36/37/38
• Molecular Structure
• Hazard Symbols Xi
• Synonyms 3,4-DIBROMOFLUOROBENZENE;1,2-DIBROMO-4-FLUOROBENZENE;1,2-Dibromo-4-fluorobenzene,98%;1,2-Dibromo-4-fluorobenzene 99%;1,2-Dibromo-4-fluorobenzene99%;3,4-Dibromo-1-fluorobenzene;1,2-DibroMo-4-fluorobenzene[3,4-DibroMofluorobenzene]
• PSA 0.00000
• LogP 3.35070

Synthetic route

462-06-6

fluorobenzene

2369-37-1

1,2,-dibromo-4-fluorobenzene

Conditions

Conditions	Yield
With bromine; iron

615-55-4

3,4-dibromoaniline

2369-37-1

1,2,-dibromo-4-fluorobenzene

Conditions

Conditions	Yield
With hydrogenchloride; tetrafluoroboric acid; sodium nitrite Erhitzen des Reaktionsprodukts auf 160grad;

460-00-4

1-Bromo-4-fluorobenzene

2369-37-1

1,2,-dibromo-4-fluorobenzene

Conditions

Conditions	Yield
With bromine; iron

371-40-4

4-fluoroaniline

2369-37-1

1,2,-dibromo-4-fluorobenzene

Conditions

Conditions	Yield
With tert.-butylnitrite; copper(ll) bromide In acetonitrile

7726-95-6

bromine

460-00-4

1-Bromo-4-fluorobenzene

iron-powder

iron-powder

A

2369-37-1

1,2,-dibromo-4-fluorobenzene

B

1435-53-6

2,4-dibromo-1-fluorobenzene

...Expand

462-06-6

fluorobenzene

1-1.3 mol bromine

1-1.3 mol bromine

iron-turnings

iron-turnings

A

2369-37-1

1,2,-dibromo-4-fluorobenzene

B

1435-53-6

2,4-dibromo-1-fluorobenzene

C

460-00-4

1-Bromo-4-fluorobenzene

...Expand

1066-35-9

dimethylmonochlorosilane

2369-37-1

1,2,-dibromo-4-fluorobenzene

1,2-bis(dimethylsilyl)-4-fluorobenzene

Conditions

Conditions	Yield
With magnesium; lithium chloride at 20℃; for 4h;	88%

557-21-1

zinc(II) cyanide

2369-37-1

1,2,-dibromo-4-fluorobenzene

65610-14-2

4-fluorophthalonitrile

Conditions

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium(0); polymethylhydroxysilane In N,N-dimethyl acetamide at 100℃; for 2h;	87%

150-19-6

O-methylresorcine

2369-37-1

1,2,-dibromo-4-fluorobenzene

2-fluoro-7-methoxydibenzo[b,d]furan

Conditions

Conditions	Yield
Stage #1: O-methylresorcine; 1,2,-dibromo-4-fluorobenzene With potassium carbonate; copper(II) oxide In N,N-dimethyl-formamide for 3h; Reflux; Stage #2: With palladium diacetate; potassium carbonate; tricyclohexylphosphine tetrafluoroborate In N,N-dimethyl-formamide at 130℃; for 12h; Inert atmosphere;	83%

75-77-4

chloro-trimethyl-silane

2369-37-1

1,2,-dibromo-4-fluorobenzene

1265682-42-5

1-fluoro-3,4-bis(trimethylsilyl)benzene

Conditions

Conditions	Yield
With magnesium; lithium chloride at 20℃; for 4h;	81%
With magnesium; ethylene dibromide In tetrahydrofuran at 20℃; for 0.75h; Inert atmosphere;	56%

2369-37-1

1,2,-dibromo-4-fluorobenzene

5720-05-8

4-methylphenylboronic acid

1424360-18-8

1,2-di(4'-methylphenyl)-4-fluorobenzene

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In 1,4-dioxane at 90℃; for 8h; Suzuki-Miyaura Coupling; Inert atmosphere;	81%

2369-37-1

1,2,-dibromo-4-fluorobenzene

98-80-6

phenylboronic acid

1424360-17-7

1,2-diphenyl-4-fluorobenzene

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In 1,4-dioxane at 90℃; for 8h; Suzuki-Miyaura Coupling; Inert atmosphere;	79%

2369-37-1

1,2,-dibromo-4-fluorobenzene

86-74-8

9H-carbazole

C18H11Br2N

Conditions

Conditions	Yield
With calcium hydride; caesium carbonate In N,N-dimethyl-formamide at 130℃; for 18h;	75%

2369-37-1

1,2,-dibromo-4-fluorobenzene

5720-07-0

4-methoxyphenylboronic acid

1424360-20-2

1,2-di(4'-methoxyphenyl)-4-fluorobenzene

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In 1,4-dioxane at 90℃; for 8h; Suzuki-Miyaura Coupling; Inert atmosphere;	70%

2369-37-1

1,2,-dibromo-4-fluorobenzene

5720-06-9

2-Methoxyphenylboronic acid

1424360-19-9

1,2-di(2'-methoxyphenyl)-4-fluorobenzene

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In 1,4-dioxane at 90℃; for 8h; Suzuki-Miyaura Coupling; Inert atmosphere;	70%

2369-37-1

1,2,-dibromo-4-fluorobenzene

1539314-91-4

1,2-dibromo-4-fluoro-3-iodobenzene

Conditions

Conditions	Yield
Stage #1: 1,2,-dibromo-4-fluorobenzene With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.5h; Stage #2: With iodine In tetrahydrofuran for 0.5h;	70%

2369-37-1

1,2,-dibromo-4-fluorobenzene

110-58-7

1-pentanamine

13939-06-5, 199620-15-0

molybdenum hexacarbonyl

351992-10-4

N-pentyl-4-fluorophthalimide

Conditions

Conditions	Yield
With palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; catacxium A In toluene at 100℃; for 16h; Sealed tube; Inert atmosphere;	60%

...Expand

2369-37-1

1,2,-dibromo-4-fluorobenzene

40972-86-9

(2,3-dimethoxyphenyl)boronic acid

1424360-23-5

1,2-di(2',3'-dimethoxyphenyl)-4-fluorobenzene

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In 1,4-dioxane at 90℃; for 8h; Suzuki-Miyaura Coupling; Inert atmosphere;	59%

2369-37-1

1,2,-dibromo-4-fluorobenzene

2156-04-9

4-Vinylphenylboronic acid

1424360-22-4

1,2-di(4'-vinylphenyl)-4-fluorobenzene

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In 1,4-dioxane at 90℃; for 8h; Suzuki-Miyaura Coupling; Inert atmosphere;	48%

2369-37-1

1,2,-dibromo-4-fluorobenzene

62-53-3

aniline

4-fluoro-N1,N2-diphenyl-benzene-1,2-diamine

Conditions

Conditions	Yield
With palladium diacetate; tri-tert-butyl phosphine; sodium t-butanolate In toluene at 110℃; for 14h;	32%

2369-37-1

1,2,-dibromo-4-fluorobenzene

87-62-7

2,6-dimethylaniline

N1,N2-bis-(2,6-dimethyl-phenyl)-4-fluoro-benzene-1,2-diamine

Conditions

Conditions	Yield
With palladium diacetate; tri-tert-butyl phosphine; sodium t-butanolate In toluene at 110℃; for 14h;	30%

2369-37-1

1,2,-dibromo-4-fluorobenzene

24544-04-5

2,6-diisopropylbenzenamine

N1,N2-bis-(2,6-diisopropyl-phenyl)-4-fluoro-benzene-1,2-diamine

Conditions

Conditions	Yield
With palladium diacetate; tri-tert-butyl phosphine; sodium t-butanolate In toluene at 110℃; for 14h;	25%

121-43-7

Trimethyl borate

2369-37-1

1,2,-dibromo-4-fluorobenzene

1435-53-6

2,4-dibromo-1-fluorobenzene

112204-57-6

dihydroxy-(5-bromo-2-fluorophenyl)-borane

Conditions

Conditions	Yield
With magnesium In tetrahydrofuran; tetrachloromethane; diethyl ether; water; acetic acid

...Expand

75-77-4

chloro-trimethyl-silane

2369-37-1

1,2,-dibromo-4-fluorobenzene

A

1265682-43-6

1-bromo-4-fluoro-2-trimethylsilylbenzene

B

1265682-44-7

2-bromo-4-fluoro-1-trimethylsilylbenzene

C

1265682-42-5

1-fluoro-3,4-bis(trimethylsilyl)benzene

Conditions

Conditions	Yield
With Rieke-magnesium (MgR) In tetrahydrofuran at 20 - 40℃; for 1.25h; Inert atmosphere;

...Expand

2369-37-1

1,2,-dibromo-4-fluorobenzene

1607434-42-3

C18H23N3OSi

Conditions

Conditions

Yield

Multi-step reaction with 4 steps 1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C 1.2: 0.5 h 2.1: diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 0.17 h / Sealed tube; Sonication 2.2: 40 h / 40 °C 3.1: tris-(dibenzylideneacetone)dipalladium(0); 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl acetamide / 26.16 h / 100 °C / Sealed tube; Sonication 4.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 0.33 h / 140 °C / Sealed tube; Microwave irradiation View Scheme

2369-37-1

1,2,-dibromo-4-fluorobenzene

C19H25N3OSi

Conditions

Conditions

Yield

Multi-step reaction with 4 steps 1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C 1.2: 0.5 h 2.1: diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 0.17 h / Sealed tube; Sonication 2.2: 40 h / 40 °C 3.1: tris-(dibenzylideneacetone)dipalladium(0); 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl acetamide / 26.16 h / 100 °C / Sealed tube; Sonication 4.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 18 h / 20 °C / Sealed tube; Inert atmosphere 4.2: 30 h / 60 °C View Scheme

2369-37-1

1,2,-dibromo-4-fluorobenzene

1539314-93-6

((2,3-dibromo-6-fluorophenyl)ethynyl)trimethylsilane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C 1.2: 0.5 h 2.1: diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 0.17 h / Sealed tube; Sonication 2.2: 40 h / 40 °C View Scheme

2369-37-1

1,2,-dibromo-4-fluorobenzene

1539314-94-7

4-fluoro-3-((trimethylsilyl)ethynyl)phthalonitrile

Conditions

Conditions

Yield

Multi-step reaction with 3 steps 1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C 1.2: 0.5 h 2.1: diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 0.17 h / Sealed tube; Sonication 2.2: 40 h / 40 °C 3.1: tris-(dibenzylideneacetone)dipalladium(0); 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl acetamide / 26.16 h / 100 °C / Sealed tube; Sonication View Scheme

2369-37-1

1,2,-dibromo-4-fluorobenzene

1539314-32-3

(S)-1-(3-hydroxy-3-methylbutan-2-yl)-1H-indole-4,5-dicarbonitrile

Conditions

Conditions

Yield

Multi-step reaction with 4 steps 1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C 1.2: 0.5 h 2.1: diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 0.17 h / Sealed tube; Sonication 2.2: 40 h / 40 °C 3.1: tris-(dibenzylideneacetone)dipalladium(0); 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl acetamide / 26.16 h / 100 °C / Sealed tube; Sonication 4.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 0.5 h / 60 °C / Sealed tube; Inert atmosphere 4.2: 0.25 h / 140 °C / Microwave irradiation View Scheme

1,2-Dibromo-4-fluorobenzene Specification