1,4-PHENYLENEDIACETIC ACID supplier

Name
1,4-Phenylenediacetic acid
EINECS 230-801-2
CAS No. 7325-46-4
Article Data21
CAS DataBase
Density 1.345 g/cm³
Solubility very soluble in water
Melting Point 248-252 °C(lit.)
Formula C₁₀H₁₀O₄
Boiling Point 410.7 °C at 760 mmHg
Molecular Weight 194.187
Flash Point 216.4 °C
Transport Information
Appearance light yellow to beige powder
Safety 26-36-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms p-Phenylenediacetic acid;p-Benzenediaceticacid (6CI,7CI,8CI);1,4-Benzenediaceticacid;
PSA 74.60000
LogP 0.94080

Synthetic route

: 622-75-3
1,4-phenylenediacetonitrile

: 7325-46-4
1,4-phenylenediacetic acid

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid at 100℃; for 2h;	90%
With hydrogenchloride; water at 100℃; for 12h;	88%
With hydrogenchloride

: 201230-82-2
carbon monoxide

: 623-25-6
p-Xylylene dichloride

: 7325-46-4
1,4-phenylenediacetic acid

Conditions

Conditions	Yield
Stage #1: carbon monoxide With C28H16N2O6Se In butan-1-ol under 750.075 Torr; for 2h; Reflux; Stage #2: p-Xylylene dichloride With tetrabutylammomium bromide; sodium hydroxide In butan-1-ol at 50℃; under 750.075 Torr; for 24h;	90%
Stage #1: carbon monoxide With C28H22CoN4O6 In butan-1-ol at 60℃; under 760.051 Torr; for 2h; Glovebox; High pressure; Green chemistry; Stage #2: p-Xylylene dichloride With tetra-(n-butyl)ammonium iodide; sodium hydroxide In butan-1-ol at 60℃; under 760.051 Torr; for 22h; Glovebox; High pressure; Green chemistry; regioselective reaction;	80%

: 623-24-5
1,4-bis(bromomethyl)benzene

: 201230-82-2
carbon monoxide

: 7325-46-4
1,4-phenylenediacetic acid

Conditions

Conditions	Yield
With chloro(1,5-cyclooctadiene)rhodium(I) dimer; potassium iodide In formic acid at 90℃; under 760 Torr; for 18h; Carbonylation;	89%

: 77295-67-1
1,4-bis(2,2-dibromoethenyl)benzene

: 7325-46-4
1,4-phenylenediacetic acid

Conditions

Conditions	Yield
Stage #1: 1,4-bis(2,2-dibromoethenyl)benzene With n-butyllithium In tetrahydrofuran at 0℃; for 1.5h; Stage #2: With 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane In tetrahydrofuran for 2h;	60%

: 36076-26-3
diethyl 2,2'-(1,4-phenylene)diacetate

: 7325-46-4
1,4-phenylenediacetic acid

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water for 9h; Heating;	57%

: 201230-82-2
carbon monoxide

: 589-29-7
p-xylylene glycol

A: 7325-46-4
1,4-phenylenediacetic acid

B: 622-47-9
4-tolylacetic acid

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); hydrogen iodide In acetone at 90℃; under 68400 Torr; for 42h;	A 48% B 16 % Spectr.

...Expand

: 201230-82-2
carbon monoxide

: 589-29-7
p-xylylene glycol

A: 106-42-3
para-xylene

B: 7325-46-4
1,4-phenylenediacetic acid

C: 622-47-9
4-tolylacetic acid

Conditions

Conditions	Yield
With hydrogen iodide; tetrakis(triphenylphosphine) palladium(0) In acetone at 90℃; under 68400 Torr; for 42h; Carbonylation; reduction;	A n/a B 48% C 16%

...Expand

: 111-65-9
octane

: 106-42-3
para-xylene

: 1822-71-5
n-pentylsodium

A: 7325-46-4
1,4-phenylenediacetic acid

B: 622-47-9
4-tolylacetic acid

C: 142-62-1
hexanoic acid

Conditions

Conditions	Yield
Behandlung des Reaktionsprodukts mit festem CO2;

...Expand

: 7398-52-9
4-acetyl-phenylacetic acid

: 7325-46-4
1,4-phenylenediacetic acid

Conditions

Conditions	Yield
With morpholine; sulfur Erwaermen des Reaktionsprodukts mit aethanol. Kalilauge;

: 1528-42-3
ethyl 4-acetylphenylacetate

: 7325-46-4
1,4-phenylenediacetic acid

Conditions

Conditions	Yield
With morpholine; sulfur Erwaermen des Reaktionsprodukts mit aethanol. Kalilauge;

: 106-42-3
para-xylene

: 7325-46-4
1,4-phenylenediacetic acid

Conditions

Conditions	Yield
With octane; n-pentylsodium anschliessendes Behandeln mit festem Kohlendioxid;

: p-phenylene-bis-thioacetic acid diamide

alcoholic potash: alcoholic potash

A: 7325-46-4
1,4-phenylenediacetic acid

B: 7783-06-4
hydrogen sulfide

C: 7664-41-7
ammonia

...Expand

: 623-25-6
p-Xylylene dichloride

: 7325-46-4
1,4-phenylenediacetic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 87 percent / triethylene glycol / 1 h / 90 °C 2: 90 percent / conc. HCl; acetic acid / 2 h / 100 °C View Scheme
Multi-step reaction with 2 steps 1: aq. ethanol / Heating 2: aq. H2SO4 / Heating View Scheme

: 101-97-3
Ethyl 2-phenylethanoate

butylamine salts: butylamine salts

: 7325-46-4
1,4-phenylenediacetic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 78 percent / SnCl4 / CH2Cl2 / 24 h / Ambient temperature 2: 86 percent / Raney nickel / ethanol / 4 h / Heating 3: 57 percent / sodium hydroxide / ethanol; H2O / 9 h / Heating View Scheme

: 105077-01-8
diethyl α-methylthio-1,4-benzenediacetate

: 7325-46-4
1,4-phenylenediacetic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 86 percent / Raney nickel / ethanol / 4 h / Heating 2: 57 percent / sodium hydroxide / ethanol; H2O / 9 h / Heating View Scheme

: 36076-26-3
diethyl 2,2'-(1,4-phenylene)diacetate

A: 113520-36-8
2-(4-(2-ethoxy-2-oxoethyl)phenyl)acetic acid

B: 7325-46-4
1,4-phenylenediacetic acid

Conditions

Conditions	Yield
With lithium hydroxide monohydrate; water In tetrahydrofuran; ethanol

: C10H8O4(2-)*Zn(2+)*C10H8N2*CH4O

A: 553-26-4
4,4'-bipyridine

B: 7325-46-4
1,4-phenylenediacetic acid

Conditions

Conditions	Yield
With sulfuric acid-d2 In dimethylsulfoxide-d6

: 935-14-8
1,4-diethynylbenzene

: 7325-46-4
1,4-phenylenediacetic acid

Conditions

Conditions	Yield
Stage #1: 1,4-diethynylbenzene With n-butyllithium In tetrahydrofuran at -78℃; for 1h; Stage #2: With 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane In tetrahydrofuran for 2h; Stage #3: With oxone In acetone at 50℃; for 12h;
Multi-step reaction with 2 steps 1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere 1.2: 2 h / -78 °C / Inert atmosphere 2.1: oxone\|\|potassium monopersulfate triple salt; water / acetone / 12 h / 50 °C / Inert atmosphere View Scheme

: 1,4-bis((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethynyl)benzene

: 7325-46-4
1,4-phenylenediacetic acid

Conditions

Conditions	Yield
With oxone\|\|potassium monopersulfate triple salt; water In acetone at 50℃; for 12h; Inert atmosphere;	689 mg

: 67-56-1
methanol

: 7325-46-4
1,4-phenylenediacetic acid

: 36076-25-2
(4-methoxycarbonylmethylphenyl)acetic acid methyl ester

Conditions

Conditions	Yield
With sulfuric acid Reflux;	100%
With sulfuric acid at 80℃; for 94h; Inert atmosphere;	90%
With thionyl chloride for 4h; Reflux;	85%

: 64-17-5
ethanol

: 7325-46-4
1,4-phenylenediacetic acid

: 36076-25-2
(4-methoxycarbonylmethylphenyl)acetic acid methyl ester

Conditions

Conditions	Yield
With sulfuric acid In water at 80℃; for 12h; Inert atmosphere;	99%

: 139024-81-0
N(1),N(2)-bis(t-butyloxycarbonyl)-1,2,4-butanetriamine

: 7325-46-4
1,4-phenylenediacetic acid

: C38H64N6O10

Conditions

Conditions	Yield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine In acetonitrile at 0 - 20℃; Reflux;	97%

: 7325-46-4
1,4-phenylenediacetic acid

: 104183-03-1
phenylenediacetic acid-2,2,2',2'-d4

Conditions

Conditions	Yield
With potassium hydroxide; water-d2 at 160℃; for 28h;	95%

: 7325-46-4
1,4-phenylenediacetic acid

: 2,3-dihydro-1H-isoindole-5,6-dicarboxylic acid 5-{[2-(4-fluoro-phenyl)-ethyl]-amide} 6-(4-methyl-benzylamide)

: C62H58F2N6O6

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 25℃; for 12h;	94%

: 2632-99-7
1,2-bis(5-methylisoxazol-3-yl)hydrazine

: 7325-46-4
1,4-phenylenediacetic acid

: 5970-45-6
zinc(II) acetate dihydrate

: [Zn(μ4-1,4-phenylenediacetate)(μ-4,4′-azobis(pyridine))0.5]n

Conditions

Conditions	Yield
In water at 70 - 120℃; for 72.5h;	93%

...Expand

: 7325-46-4
1,4-phenylenediacetic acid

: 5140-03-4
2-[4-(2-hydroxyethyl)phenyl]ethan-1-ol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran Ambient temperature;	92%
Stage #1: 1,4-phenylenediacetic acid With dimethyl sulfide borane In tetrahydrofuran for 18h; Stage #2: With hydrogenchloride In tetrahydrofuran; water	87%
With dimethylsulfide borane complex In tetrahydrofuran at 0 - 20℃; for 24h; Inert atmosphere;	81.8%

: 7325-46-4
1,4-phenylenediacetic acid

: 854154-95-3
4'-methoxy-N-(azulen-1-ylmethylene)aniline

: 1,4-bis[(E)-2-(azulen-1-yl)vinyl]benzene

Conditions

Conditions	Yield
for 10h; Heating;	91%

: 123-75-1
pyrrolidine

: 7677-24-9
trimethylsilyl cyanide

: 7325-46-4
1,4-phenylenediacetic acid

: C20H26N4

Conditions

Conditions	Yield
Stage #1: pyrrolidine; 1,4-phenylenediacetic acid With (dimethoxy)methylsilane; molybdenum hexacarbonyl at 65℃; Stage #2: trimethylsilyl cyanide In 2,2,2-trifluoroethanol at 20℃; for 1h; chemoselective reaction;	91%

...Expand

: 64-17-5
ethanol

: 7325-46-4
1,4-phenylenediacetic acid

: 36076-26-3
diethyl 2,2'-(1,4-phenylene)diacetate

Conditions

Conditions	Yield
With sulfuric acid for 15h; Reflux;	90%
With sulfuric acid at 80℃;	87%
With sulfuric acid for 18h; Heating;	74%
acetyl chloride for 18h; Heating / reflux;

: 7325-46-4
1,4-phenylenediacetic acid

: 39246-00-9
1,4-benzenediacetaldehyde

Conditions

Conditions	Yield
With triethylsilane; tris(pentafluorophenyl)borate In benzene at 23℃; for 6h; Schlenk technique; Inert atmosphere;	90%
Multi-step reaction with 3 steps 1: 74 percent / aq. H2SO4 / 18 h / Heating 2: 84 percent / LiAlH4 / diethyl ether / 3 h / Heating 3: 62 percent / Dess-Matin periodinane / CH2Cl2 / 4 h / 20 °C View Scheme

: europium(III) nitrate hexahydrate

: 7325-46-4
1,4-phenylenediacetic acid

: [(europium(III))2(1,4-phenylenediacetate)3(H2O)] dihydrate

Conditions

Conditions	Yield
In N,N-dimethyl acetamide; water High Pressure; mixt. of Eu(NO3)3*6H2O (0.4 mmol), H2pda (0.6 mmol), H2O and dimethylacetamide heated in Teflon-lined autoclave at 105°C for 2 d, cooled slowly to room temp.; elem. anal.;	90%

: yttrium(lll) nitrate hexahydrate

: 7325-46-4
1,4-phenylenediacetic acid

: [Y2(1,4-phenylenediacetate)3(H2O)1]*2H2O

Conditions

Conditions	Yield
In ethanol; water at 180℃; for 1.16667h;	90%

: 7325-46-4
1,4-phenylenediacetic acid

: (3S,4S)-N3,N4-bis(((1S,2R)-2-phenylcyclopropyl)carbamoyl)pyrrolidine-3,4-dicarboxamide hydrochloride

: (3S,3’S,4S,4’S)-1,1’-((1,4-phenylene)diacetyl)-bis(N3,N4-bis((1S,2R)-2-phenylcyclopropyl)pyrrolidine-3,4-dicarboxamide)

Conditions

Conditions	Yield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 23℃; for 18h;	89%

: 7325-46-4
1,4-phenylenediacetic acid

: 63468-90-6
phenylglyoxylic acid potassium salt

: 104595-14-4
1,4-Phenylene bis(phenylmaleic anhydride)

Conditions

Conditions	Yield
With acetic anhydride for 1h; Heating;	88%

: nickel(II) nitrate hexahydrate

: 7325-46-4
1,4-phenylenediacetic acid

: 794485-43-1
1,3-bis(1H-imidazol-4-yl)benzene

: 7732-18-5
water

: C12H10N4*C10H8O4(2-)*H2O*Ni(2+)

Conditions

Conditions	Yield
With sodium hydroxide at 120℃; for 72h; Sealed tube; Autoclave;	88%

...Expand

: 7325-46-4
1,4-phenylenediacetic acid

: 4559-70-0
Diphenylphosphine oxide

: 38661-56-2
(1,4-phenylenebis(methylene))bis(diphenylphosphine oxide)

Conditions

Conditions	Yield
With sodium persulfate; silver carbonate In acetonitrile at 80℃;	88%

: 7325-46-4
1,4-phenylenediacetic acid

: 21062-19-1
1,4-benzenediacetyl dichloride

Conditions

Conditions	Yield
With Vilsmeier reagent In toluene at 35 - 40℃; for 0.25h;	87%
With thionyl chloride
With phosphorus pentachloride

: 7325-46-4
1,4-phenylenediacetic acid

: 72087-28-6
L-Leu-L-Pro-OMe

: 668479-44-5
1,4-phenylenedi(acetyl-L-leucyl-L-proline methyl ester)

Conditions

Conditions	Yield
Stage #1: 1,4-phenylenediacetic acid With diisopropyl-carbodiimide In dichloromethane for 0.75h; Stage #2: L-Leu-L-Pro-OMe In dichloromethane for 16h;	86%

: gadolinium(III) nitrate hexahydrate

: 7325-46-4
1,4-phenylenediacetic acid

: [(gadolinium(III))2(1,4-phenylenediacetate)3(H2O)] dihydrate

Conditions

Conditions	Yield
In N,N-dimethyl acetamide; water High Pressure; mixt. of Gd(NO3)3*6H2O (0.4 mmol), H2pda (0.6 mmol), H2O and dimethylacetamide heated in Teflon-lined autoclave at 105°C for 2 d, cooled slowly to room temp.; elem. anal.;	86%

: 7325-46-4
1,4-phenylenediacetic acid

: zinc(II) nitrate hexahydrate

: 4,4'-di(4-pyridyl)stilbene

: [Zn(1,4-pda)(4,4'-di(4-pyridyl)stilbene)]n

Conditions

Conditions	Yield
In water for 72h; Autoclave; High pressure;	86%

...Expand

: cobalt(II) chloride hexahydrate

: 7325-46-4
1,4-phenylenediacetic acid

: 7732-18-5
water

: [Co(1,4-phenylenediacetate)(H2O)2]

Conditions

Conditions	Yield
With sodium carbonate In water High Pressure; addn. of aq. soln. of sodium carbonate to aq. soln. of carbon compd., addn. of aq. soln. of cobalt compd. at room temp., sealing in stainless steel reactor, heating at 120°C for 48 h; cooling, isolation of crystals by hand, washing with water, drying over filter paper, elem. anal.;	85%

...Expand

: yttrium(lll) nitrate hexahydrate

: europium(III) nitrate hexahydrate

: 7325-46-4
1,4-phenylenediacetic acid

: [Y1.8Eu0.2(1,4-phenylenediacetate)3(H2O)1]*2H2O

Conditions

Conditions	Yield
In ethanol; water at 180℃; for 1.16667h; Milling;	85%

...Expand

: 7325-46-4
1,4-phenylenediacetic acid

: 611-73-4
Benzoylformic acid

: 104595-14-4
1,4-Phenylene bis(phenylmaleic anhydride)

Conditions

Conditions	Yield
With acetic anhydride; sodium hydride Reflux;	85%

1,4-PHENYLENEDIACETIC ACID Chemical Properties

The MF of 1,4-PHENYLENEDIACETIC ACID(7325-46-4): C₁₀H₁₀O₄
The MW of 1,4-PHENYLENEDIACETIC ACID(7325-46-4): 194.18
EINECS: 230-801-2
mp: 248-252 °C(lit.)
Density: 1.345 g/cm³
Flash Point: 216.4 °C
Boiling Point: 410.7 °C at 760 mmHg
Index of Refraction: 1.586
Categories: Aromatic Phenylacetic Acids and Derivatives;C10;Carbonyl Compounds;Carboxylic Acids
Synonyms: BENZENE-1,4-DIACETIC ACID;1,4-PHENYLENEDIACETIC ACID;P-BENZENEDIACETIC ACID;P-PHENYLENEDIACETIC ACID;RARECHEM AL BO 0138;1,4-Benzenediacetic acid;4-Phenylenediacetic acid;1,4-Phenylenebis(acetic acid)
The Structure of 1,4-PHENYLENEDIACETIC ACID(7325-46-4):

1,4-PHENYLENEDIACETIC ACID Safety Profile

Hazard Codes:

Xi
Risk Statements: 36/37/38
Risk Statements: 36/37/38
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 26-36-37/39
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37/39: Wear suitable gloves and eye/face protection
WGK Germany: 3
TSCA: T

Product Name

1,4-Phenylenediacetic acid

Synthetic route

1,4-PHENYLENEDIACETIC ACID Chemical Properties

1,4-PHENYLENEDIACETIC ACID Safety Profile

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