1-Fluoro-2-nitrobenzene supplier

Name
1-Fluoro-2-nitrobenzene
EINECS 216-088-0
CAS No. 1493-27-2
Article Data122
CAS DataBase
Density 1.338 g/cm³
Solubility immiscible with water
Melting Point -9 - -6 °C(lit.)
Formula C₆H₄FNO₂
Boiling Point 228.863 °C at 760 mmHg
Molecular Weight 141.102
Flash Point 94.444 °C
Transport Information
Appearance clear yellow to brownish liquid
Safety 26-36/37
Risk Codes 36/37/38-20/21/22
Molecular Structure
Hazard Symbols Xn,T,Xi
Synonyms 2-Fluoronitrobenzene;o-Fluoronitrobenzene;2-Nitrofluorobenzene;o-Nitrofluorobenzene;Benzene, o-nitrofluoro-;2-Fluoro Nitro Benzene;
PSA 45.82000
LogP 2.25710

Synthetic route

: 577-19-5
2-nitrophenyl bromide

: 1493-27-2
ortho-nitrofluorobenzene

Conditions

Conditions	Yield
With Cu(Ph3P)3F In N,N-dimethyl-formamide at 170℃; for 5h;	100%

: 528-29-0
1,2-Dinitrobenzene

: 1493-27-2
ortho-nitrofluorobenzene

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride In tetrahydrofuran for 1.5h; Ambient temperature;	100%
With tetrabutyl ammonium fluoride In tetrahydrofuran; water; N,N-dimethyl-formamide at 20℃; for 1h;	72%
With tetrabutyl ammonium fluoride In tetrahydrofuran Ambient temperature; Yield given;
With tetraphenylphosphonium hydrogendifluoride In sulfolane at 100℃; for 2h;	70 % Chromat.
With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 1.5h; Inert atmosphere; chemoselective reaction;	97.4 %Chromat.

: 1993-03-9
o-fluorophenylboronic acid

: 1493-27-2
ortho-nitrofluorobenzene

Conditions

Conditions	Yield
With nitric acid In 1,2-dichloro-ethane at 70℃; for 16h; Inert atmosphere;	96%
With N-Bromosuccinimide; [bis(trifluoroacetoxy)iodo]benzene; sodium nitrite In acetonitrile at 20℃; for 3h; regioselective reaction;	80%
With N–nitrosuccinimide; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate In acetonitrile at 20℃; for 19h; Inert atmosphere; Irradiation;	68%
Multi-step reaction with 2 steps 1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 20 °C / Sealed tube 1.2: 0.25 h / 20 °C / Sealed tube 2.1: sodium triflate; sodium nitrite / ethyl acetate / 16 h / 70 °C / Sealed tube View Scheme

: 453-71-4
3-nitro-4-fluorobenzoic acid

: 1493-27-2
ortho-nitrofluorobenzene

Conditions

Conditions	Yield
With sulfolane; sodium hydrogencarbonate at 190℃; for 2h;	92%

: 14937-45-2
cetyltributylphosphonium bromide

: 88-73-3
2-Chloronitrobenzene

: 1493-27-2
ortho-nitrofluorobenzene

Conditions

Conditions	Yield
With potassium fluoride	91.2%

: 88-73-3
2-Chloronitrobenzene

: 1493-27-2
ortho-nitrofluorobenzene

Conditions

Conditions	Yield
With potassium fluoride; polydiallyldimethylammonium chloride In dimethyl sulfoxide at 200℃; for 3h;	90.1%
With potassium fluoride; bis(tricyclohexylphosphine)nickel(II) dichloride; tetrabutyl ammonium fluoride In N,N-dimethyl-formamide at 150℃; for 8h; Inert atmosphere;	79.8%
With potassium fluoride; bis(triphenylphosphine)iminium chloride In dimethyl sulfoxide at 150℃; for 8h; Inert atmosphere;	76%

: undecyltributylammonium bromide

: 88-73-3
2-Chloronitrobenzene

: 1493-27-2
ortho-nitrofluorobenzene

Conditions

Conditions	Yield
With potassium fluoride	84.6%

: 462-06-6
fluorobenzene

A: 350-46-9
4-Fluoronitrobenzene

B: 1493-27-2
ortho-nitrofluorobenzene

Conditions

Conditions	Yield
With nitric acid at 50℃; for 3h;	A 84.4% B 13.9%
With 2-nitrobenzo[d]isothiazol-3(2H)-one 1,1-dioxide at 55 - 60℃; for 3h; Inert atmosphere; Sealed tube; Overall yield = 96 percent;	A 76.8% B 19.2%
With aluminium trichloride; dinitrogen tetraoxide; Petroleum ether

: 1034926-54-9
bis(2-fluorophenyl)iodonium tetrafluoroborate

: 1493-27-2
ortho-nitrofluorobenzene

Conditions

Conditions	Yield
With sodium triflate; sodium nitrite In ethyl acetate at 70℃; for 16h; Sealed tube;	84%

: 609-73-4
o-nitroiodobenzene

: 1493-27-2
ortho-nitrofluorobenzene

Conditions

Conditions	Yield
Stage #1: o-nitroiodobenzene With phenyllithium In tetrahydrofuran; diethyl ether; cyclohexane at -28℃; Flow reactor; Stage #2: With N-fluorobis(benzenesulfon)imide In tetrahydrofuran; diethyl ether; cyclohexane at -28℃; Flow reactor;	83%

: 1119-97-7
cetyltrimethylammonium bromide

: 88-73-3
2-Chloronitrobenzene

: 1493-27-2
ortho-nitrofluorobenzene

Conditions

Conditions	Yield
With potassium fluoride In water; toluene	78%

: 110-01-0
thiophene

: 88-73-3
2-Chloronitrobenzene

: 1493-27-2
ortho-nitrofluorobenzene

Conditions

Conditions	Yield
	70%

: 98-95-3
nitrobenzene

A: 402-67-5
3-fluoro-1-nitrobenzene

B: 19064-24-5
2,6-difluoro-1-nitrobenzene

C: 350-46-9
4-Fluoronitrobenzene

D: 1493-27-2
ortho-nitrofluorobenzene

Conditions

Conditions	Yield
With tetrafluoroammonium tetrafluoroborate In hydrogen fluoride at 0℃; Further byproducts given. Title compound not separated from byproducts;	A 62% B n/a C 6% D 15%
With tetrafluoroammonium tetrafluoroborate In hydrogen fluoride at 0℃; Yield given. Further byproducts given. Title compound not separated from byproducts;	A 62% B n/a C 6% D 15%
With tetrafluoroammonium tetrafluoroborate In hydrogen fluoride at 0℃; Further byproducts given. Title compound not separated from byproducts;	A 62 % Spectr. B n/a C 6 % Spectr. D 15 % Spectr.

...Expand

: 13118-30-4
dimethyl-(2-nitro-phenyl)-sulfonium ; methyl sulfate

A: 3058-47-7
methyl 2-nitrophenyl sulfide

B: 1493-27-2
ortho-nitrofluorobenzene

Conditions

Conditions	Yield
With cesium fluoride In N,N-dimethyl-formamide at 100℃; for 0.166667h;	A 25% B 56%

: 609-73-4
o-nitroiodobenzene

A: 98-95-3
nitrobenzene

B: 1493-27-2
ortho-nitrofluorobenzene

Conditions

Conditions	Yield
Stage #1: o-nitroiodobenzene With phenyllithium In tetrahydrofuran; diethyl ether; cyclohexane at -28℃; Flow reactor; Stage #2: With 2-fluoro-3,3-dimethyl-2,3-dihydro-1,2-benzisothiazole-1,1-dioxide In tetrahydrofuran; diethyl ether; cyclohexane at -28℃; Flow reactor;	A 24% B 56%

: 552-16-9
ortho-nitrobenzoic acid

: 1493-27-2
ortho-nitrofluorobenzene

Conditions

Conditions	Yield
Stage #1: ortho-nitrobenzoic acid With tetrakis(acetonitrile)copper(I)tetrafluoroborate; tetrabutylammonium tetra(tert-butyl alcohol) coordinate fluoride; copper(II) bis(trifluoromethanesulfonate) In acetonitrile at 23℃; for 0.5h; Sealed tube; Inert atmosphere; Stage #2: In acetonitrile at 35℃; Irradiation; Sealed tube; Inert atmosphere;	54%

: 348-54-9
2-Fluoroaniline

: 76-05-1
trifluoroacetic acid

A: 2,2,2-trifluoro-N-(2-fluoro-6-hydroxyphenyl)acetamide

B: 1493-27-2
ortho-nitrofluorobenzene

C: 401-44-5
2,2'-difluoroazobenzene

Conditions

Conditions	Yield
With Oxone In dimethyl sulfoxide at 90℃; Schlenk technique; Inert atmosphere; chemoselective reaction;	A 25% B 15% C 40%

...Expand

: 348-54-9
2-Fluoroaniline

: 76-05-1
trifluoroacetic acid

A: 10595-66-1
2,2,2-trifluoro-N-(2-hydroxyphenyl)acetamide

B: 2,2,2-trifluoro-N-(2-fluoro-6-hydroxyphenyl)acetamide

C: 1493-27-2
ortho-nitrofluorobenzene

Conditions

Conditions	Yield
With Oxone In acetonitrile at 90℃; Schlenk technique; Inert atmosphere; chemoselective reaction;	A 10% B 25% C 8%

...Expand

: 348-54-9
2-Fluoroaniline

: 76-05-1
trifluoroacetic acid

A: 1493-27-2
ortho-nitrofluorobenzene

B: 401-44-5
2,2'-difluoroazobenzene

Conditions

Conditions	Yield
With Oxone In N,N-dimethyl-formamide at 90℃; Schlenk technique; Inert atmosphere; chemoselective reaction;	A 10% B 20%

...Expand

: 767-00-0
4-cyanophenol

: 528-29-0
1,2-Dinitrobenzene

A: 113344-23-3
4-(2-nitrophenoxy)benzonitrile

B: 1493-27-2
ortho-nitrofluorobenzene

Conditions

Conditions	Yield
With potassium fluoride In dimethyl sulfoxide at 110℃; for 2h;	A n/a B 10%
With potassium fluoride In dimethyl sulfoxide at 110℃; for 2h;	A n/a B 10 % Chromat.

...Expand

: 348-54-9
2-Fluoroaniline

: 76-05-1
trifluoroacetic acid

: 1493-27-2
ortho-nitrofluorobenzene

Conditions

Conditions	Yield
With Oxone In dichloromethane at 90℃; Schlenk technique; Inert atmosphere; chemoselective reaction;	10%

: 462-06-6
fluorobenzene

: 591-09-3
nitro acetate

A: 350-46-9
4-Fluoronitrobenzene

B: 1493-27-2
ortho-nitrofluorobenzene

...Expand

: 462-06-6
fluorobenzene

: 1493-27-2
ortho-nitrofluorobenzene

Conditions

Conditions	Yield
With nitric acid; phosphorus pentoxide beim Nitrieren; Trennung vom p-Isomeren durch fraktionierte Destillation und Krystallisation;

: 364-76-1
4-Fluoro-3-nitroaniline

: 1493-27-2
ortho-nitrofluorobenzene

Conditions

Conditions	Yield
Diazotization.nachfolgend Reduktion zu 4-Fluor-3-nitro-phenylhydrazin und Oxydation mit Kupfersulfat;

: 462-06-6
fluorobenzene

: 598-58-3
methyl nitrate

A: 402-67-5
3-fluoro-1-nitrobenzene

B: 350-46-9
4-Fluoronitrobenzene

C: 1493-27-2
ortho-nitrofluorobenzene

Conditions

Conditions	Yield
Product distribution; gas-phase radiolytic nitration;

...Expand

: 462-06-6
fluorobenzene

A: 402-67-5
3-fluoro-1-nitrobenzene

B: 350-46-9
4-Fluoronitrobenzene

C: 1493-27-2
ortho-nitrofluorobenzene

Conditions

Conditions	Yield
With silver nitrate; boron trifluoride In acetonitrile at 25℃; for 10h; Product distribution; competitive nitration benzene, relative rate;	A 1 % Chromat. B 72 % Chromat. C 27 % Chromat.
With methyl nitrate; methane at 37.6℃; Product distribution; Irradiation; gas-phase nitration by radiolytically formed MeO(1+)(H)NO2;
With nitro acetate; H-ZSM-11 In hexane at 30℃; Product distribution; different catalysts;

...Expand

: 462-06-6
fluorobenzene

A: 402-67-5
3-fluoro-1-nitrobenzene

B: 1493-27-2
ortho-nitrofluorobenzene

Conditions

Conditions	Yield
With K10 montmorillonite-supported cupric nitrate; acetic anhydride In hexane for 48h; Product distribution; Ambient temperature; var. halobenzenes, other solvent, other time;

: 1443-80-7
4-cyanophenyl methyl ketone

: 34467-51-1, 1493-27-2
1-fluoro-2-nitro-benzene radical anion

A: C9H7NO(1-)

B: 1493-27-2
ortho-nitrofluorobenzene

Conditions

Conditions	Yield
at 149.9℃; Thermodynamic data; ΔG0;

...Expand

: 108-91-8
cyclohexylamine

: 1493-27-2
ortho-nitrofluorobenzene

: 6373-71-3
N-cyclohexyl-2-nitroaniline

Conditions

Conditions	Yield
In toluene at 25℃; Rate constant; also in DMSO;	100%
In toluene at 25℃;	100%
	97%

: 1493-27-2
ortho-nitrofluorobenzene

: 74-89-5
methylamine

: 612-28-2
2-nitro-N-methylaniline

Conditions

Conditions	Yield
In ethanol; water Reflux;	100%
In methanol; water Heating;	98%
In water at 20℃; for 2h; Inert atmosphere;	93%

: 108-00-9
N,N-dimethylethylenediamine

: 1493-27-2
ortho-nitrofluorobenzene

: 25238-55-5
N1,N1-dimethyl-N2-(2-nitrophenyl)ethane-1,2-diamine

Conditions

Conditions	Yield
In toluene at 25℃; Rate constant; also in DMSO;	100%
In toluene at 25℃;	100%
In isopropyl alcohol at 90 - 100℃; for 16h;	92%

: 123-75-1
pyrrolidine

: 1493-27-2
ortho-nitrofluorobenzene

: 40832-79-9
1-(2-nitrophenyl)pyrrolidine

Conditions

Conditions	Yield
In tetrahydrofuran at 50℃; under 5400430 Torr; for 20h;	100%
With potassium carbonate In acetonitrile for 3h; Heating / reflux;	100%
With potassium carbonate In acetonitrile at 90℃; for 3h; Inert atmosphere;	99%

: 110-89-4
piperidine

: 1493-27-2
ortho-nitrofluorobenzene

: 15822-77-2
1-(2-nitrophenyl)piperidine

Conditions

Conditions	Yield
In toluene at 25℃;	100%
In toluene at 25℃; Rate constant; Mechanism; also in DMSO;	100%
With potassium phosphate; TPGS-750-M In water at 20℃; for 18h; Inert atmosphere;	99%

: 288-32-4
1H-imidazole

: 1493-27-2
ortho-nitrofluorobenzene

: 23309-16-2
1-(2-nitrophenyl)-1H-imidazole

Conditions

Conditions	Yield
With 1,2,3-Benzotriazole; potassium tert-butylate; copper(l) iodide In dimethyl sulfoxide at 110℃; for 0.5h;	100%
With pyridine; potassium carbonate; copper(II) oxide at 115℃; Ullmann Condensation;	96%
With potassium carbonate In acetonitrile for 24h; Heating;	95%

: 91-21-4
1,2,3,4-tetrahydroisoquinoline

: 1493-27-2
ortho-nitrofluorobenzene

: 140381-66-4
1,2,3,4-tetrahydro-2-(2-nitrophenyl)isoquinoline

Conditions

Conditions	Yield
In neat (no solvent) at 100℃; for 1h;	100%
With potassium carbonate In dimethyl sulfoxide at 100℃;	81%
With potassium carbonate In N,N-dimethyl-formamide Inert atmosphere; Reflux;	60%

: 95-56-7
2-hydroxybromobenzene

: 1493-27-2
ortho-nitrofluorobenzene

: 60671-89-8
1-(2-bromophenoxy)-2-nitrobenzene

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 95℃; for 23h;	100%
With potassium carbonate In dimethyl sulfoxide at 95℃;	95%
With caesium carbonate In N,N-dimethyl-formamide at 0 - 80℃; for 3h;	90%

: 105-56-6
ethyl 2-cyanoacetate

: 1493-27-2
ortho-nitrofluorobenzene

: 65548-02-9
(+/-)-ethyl cyano(2-nitrophenyl)acetate

Conditions

Conditions	Yield
With sodium hydride In dimethyl sulfoxide 1.) 10 min, 2.) 90 deg C, 0.5 h;	100%
With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In dimethyl sulfoxide at 20 - 90℃; Inert atmosphere;	99%
Stage #1: ethyl 2-cyanoacetate With potassium tert-butylate In tetrahydrofuran for 0.25h; Cooling with ice; Stage #2: ortho-nitrofluorobenzene In tetrahydrofuran for 3h; Reflux;	96.4%

: 1745-07-9
6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

: 1493-27-2
ortho-nitrofluorobenzene

: 93649-88-8
6,7-dimethoxy-(N-2-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline

Conditions

Conditions	Yield
In neat (no solvent) at 100℃; for 1h;	100%
With potassium carbonate In dimethyl sulfoxide at 100℃; for 4h;	40%
With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 12h;
With potassium carbonate In N,N-dimethyl-formamide at 120℃;

: 17173-27-2
methyl 2-(2-acetyl-4,5-dimethoxyphenyl)acetate

: 1493-27-2
ortho-nitrofluorobenzene

: 278801-02-8
methyl 2-[2-(2-nitrophenyl)acetyl]-4,5-dimethoxyphenylacetate

Conditions

Conditions	Yield
With sulfuric acid In 1,4-dioxane for 2h; Heating;	100%

: 95-48-7
ortho-cresol

: 1493-27-2
ortho-nitrofluorobenzene

: 54106-40-0
1-methyl-2-(2-nitrophenoxy)benzene

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 95℃; for 20h;	100%
Stage #1: ortho-cresol With sodium hydride In N,N-dimethyl-formamide at 20℃; for 1h; Inert atmosphere; Stage #2: ortho-nitrofluorobenzene In N,N-dimethyl-formamide at 20 - 50℃; for 13h; Inert atmosphere;	93%
Stage #1: ortho-cresol With potassium tert-butylate In tetrahydrofuran for 1h; Stage #2: ortho-nitrofluorobenzene In tetrahydrofuran

: 769-92-6
4-tert-Butylaniline

: 1493-27-2
ortho-nitrofluorobenzene

: 188844-98-6
(4-tert-butyl-phenyl)-(2-nitro-phenyl)-amine

Conditions

Conditions	Yield
In dimethyl sulfoxide at 100℃;	100%
With caesium carbonate; tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide at 65℃; for 18h;	54%
With triethylamine In N,N-dimethyl-formamide at 80℃; for 12h;

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 1493-27-2
ortho-nitrofluorobenzene

: 5761-36-4
N-[2-(3,4-dimethoxyphenyl)ethyl]-2-nitroaniline

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 70℃; for 16h;	100%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 0.0966667h; microwave irradiation;
With diisopropylamine In N,N-dimethyl-formamide microwave irradiation;
With potassium carbonate In N,N-dimethyl-formamide at 60℃;
With potassium carbonate In N,N-dimethyl-formamide at 60℃; Microwave irradiation;

: 1493-27-2
ortho-nitrofluorobenzene

: 106-40-1
4-bromo-aniline

: 58476-59-8
4-bromo-N-(2-nitrophenyl)benzenamine

Conditions

Conditions	Yield
In dimethyl sulfoxide at 100℃; for 48h; Inert atmosphere; Schlenk technique;	100%
With potassium fluoride at 170 - 180℃; for 30h;	92%
With potassium fluoride at 150℃; for 18h; Inert atmosphere;	90%

: 1493-27-2
ortho-nitrofluorobenzene

: 147-85-3
L-proline

: 31981-54-1
(S)-N-(2-nitrophenyl)proline

Conditions

Conditions	Yield
With sodium hydrogencarbonate In ethanol; water for 5h; Heating;	100%
With sodium hydrogencarbonate In ethanol; water Heating;	94%
With triethylamine In dimethyl sulfoxide	80.3%
With sodium hydrogencarbonate In ethanol; water at 100℃;

: 1529-17-5
phenyltrimethylsilyl ether

: 1493-27-2
ortho-nitrofluorobenzene

: 2216-12-8
1-nitro-2-phenoxy-benzene

Conditions

Conditions	Yield
t-Bu-P4 base In hexane; N,N-dimethyl-formamide at 20℃; for 6h;	100%

: 26734-09-8
3-amino-2,2-dimethylpropan-1-ol

: 1493-27-2
ortho-nitrofluorobenzene

: 336106-21-9
2,2-dimethyl-3-(2-nitrophenylamino)propan-1-ol

Conditions

Conditions	Yield
In dimethyl sulfoxide at 20℃; for 3h;	100%

: 1493-27-2
ortho-nitrofluorobenzene

: 111-27-3
hexan-1-ol

: 67285-54-5
1-(hexyloxy)-2-nitrobenzene

Conditions

Conditions	Yield
With triethylsilane; t-Bu-P4 In hexane; dimethyl sulfoxide at 100℃; for 2h;	100%

: 1493-27-2
ortho-nitrofluorobenzene

: 147081-49-0
(R)-3-aminopyrrolidine-1-carboxylic acid tert-butyl ester

: tert-butyl (R)-3-((2-nitrophenyl)amino)pyrrolidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: (R)-3-aminopyrrolidine-1-carboxylic acid tert-butyl ester With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.333333h; Stage #2: ortho-nitrofluorobenzene In N,N-dimethyl-formamide at 80℃; for 16h;	100%
With potassium carbonate In N,N-dimethyl-formamide at 60℃;

: 23159-07-1
3-(1-pyrrolidinyl)propylamine

: 1493-27-2
ortho-nitrofluorobenzene

: 88858-51-9
2-Nitro-1-(3-pyrrolidino-propylamino)-benzol

Conditions

Conditions	Yield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 20℃; for 16h;	100%
In tetrahydrofuran at 30℃; for 12h; Inert atmosphere;

: 142-25-6
N,N',N'-trimethylenediamine

: 1493-27-2
ortho-nitrofluorobenzene

: 371244-16-5
N,N,N'-trimethyl-N'-(2-nitrophenyl)-1,2-ethanediamine

Conditions

Conditions	Yield
With sodium hydrogencarbonate In ethanol at 80℃; for 16h;	100%

: 1493-27-2
ortho-nitrofluorobenzene

: 140645-23-4
1,1-dimethylethyl (3R)-3-(aminomethyl)-1-piperidinecarboxylate

: 876590-06-6
1,1-dimethylethyl (3R)-3-{[(2-nitrophenyl)amino]methyl}-1-piperidinecarboxylate

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 5h; Heating / reflux;	100%
With potassium carbonate In acetonitrile for 5h; Heating / reflux;	100%
With potassium carbonate In acetonitrile Reflux;	98%

: 1493-27-2
ortho-nitrofluorobenzene

: 22951-96-8
L-3-(2-thienyl)alanine

: 911359-29-0
(S)-2-(2-nitrophenylamino)-3-(thiophen-2-yl)propanoic acid

Conditions

Conditions	Yield
With potassium carbonate In ethanol; water at 20 - 100℃; for 16h;	100%
With potassium carbonate In ethanol; water at 20 - 100℃; for 16h;	100%
With potassium carbonate In ethanol; water at 100℃; for 16h; sealed tube;	95%

: 828-27-3
4-Trifluoromethoxyphenol

: 1493-27-2
ortho-nitrofluorobenzene

: 23891-48-7
1-nitro-2-[4 (trifluoromethoxy)phenoxy]benzene

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 5h; Product distribution / selectivity; Heating / reflux;	100%

: 1493-27-2
ortho-nitrofluorobenzene

: 3888-84-4
4-fluoro-3-nitro-benzenesulfonic acid

Conditions

Conditions	Yield
With sulfuric acid at 60℃; for 0.5h;	100%
With sulfuric acid; sulfur trioxide at 60℃; for 0.5h;
With chlorosulfonic acid at 80℃; for 10h;

: 1493-27-2
ortho-nitrofluorobenzene

: (2S)-aminopentanoic acid tert-butyl ester hydrochloride

: 1090903-13-1
(S)-2-(2-nitro-phenylamino)-pentanoic acid tert-butyl ester

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 70℃;	100%

: 1493-27-2
ortho-nitrofluorobenzene

: 765-30-0
Cyclopropylamine

: 55432-23-0
cyclopropyl-(2-nitro-phenyl)-amine

Conditions

Conditions	Yield
With triethylamine In acetonitrile at 110℃;	100%
In dimethyl sulfoxide at 20 - 80℃;	100%
at 20℃; for 12h;	90.3%

1-Fluoro-2-nitrobenzene Specification

The 1-Fluoro-2-nitrobenzene, with the CAS registry number 1493-27-2, is also known as 2-Fluoronitrobenzene. It belongs to the product categories of Benzene derivatives; Nitro Compounds; Nitrogen Compounds; Organic Building Blocks; Aryl Fluorinated Building Blocks; Building Blocks; C6; Chemical Synthesis; Fluorinated Building Blocks; Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks. Its EINECS number is 216-088-0. This chemical's molecular formula is C₆H₄FNO₂ and molecular weight is 141.10. What's more, its systematic name is 1-Fluoro-2-nitrobenzene. This chemical should be sealed and stored in a cool, ventilated and dry place. Moreover, it should be ensured that the workshop is well ventilated or equipped with exhaust devices. It is used as intermediates in pesticide,medical and dye industries.

Physical properties of 1-Fluoro-2-nitrobenzene are: (1)ACD/LogP: 1.831; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.83; (4)ACD/LogD (pH 7.4): 1.83; (5)ACD/BCF (pH 5.5): 14.52; (6)ACD/BCF (pH 7.4): 14.52; (7)ACD/KOC (pH 5.5): 236.21; (8)ACD/KOC (pH 7.4): 236.21; (9)#H bond acceptors: 3; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 45.82 Å²; (13)Index of Refraction: 1.534; (14)Molar Refractivity: 32.792 cm³; (15)Molar Volume: 105.485 cm³; (16)Polarizability: 13×10^-24cm³; (17)Surface Tension: 42.8 dyne/cm; (18)Density: 1.338 g/cm³; (19)Flash Point: 94.444 °C; (20)Enthalpy of Vaporization: 44.655 kJ/mol; (21)Boiling Point: 228.863 °C at 760 mmHg; (22)Vapour Pressure: 0.1 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
This chemical is harmful by inhalation, in contact with skin and if swallowed. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need wear suitable protective clothing and gloves.

You can still convert the following datas into molecular structure:
(1)SMILES: O=[N+]([O-])c1ccccc1F
(2)Std. InChI: InChI=1S/C6H4FNO2/c7-5-3-1-2-4-6(5)8(9)10/h1-4H
(3)Std. InChIKey: PWKNBLFSJAVFAB-UHFFFAOYSA-N

Product Name

1-Fluoro-2-nitrobenzene

Synthetic route

1-Fluoro-2-nitrobenzene Specification

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