3,4-difluorophenylmagnesium bromide
(3,4-difluorophenyl)boronic acid
Conditions | Yield |
---|---|
With Triisopropyl borate In tetrahydrofuran at -40 - 0℃; | 41% |
C6H3BF5(1-)
(3,4-difluorophenyl)boronic acid
Conditions | Yield |
---|---|
In phosphate buffer pH=6.9 - 7.0; Kinetics; |
(3,4-difluorophenyl)boronic acid
Conditions | Yield |
---|---|
With hydrogenchloride; water In tetrahydrofuran pH=5; |
3-bromo-5-methylpyridin-2-amine
(3,4-difluorophenyl)boronic acid
3-(3,4-difluorophenyl)-5-methylpyridin-2-amine
Conditions | Yield |
---|---|
With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In 1,4-dioxane; water at 100℃; for 1h; Inert atmosphere; | 100% |
With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In 1,4-dioxane; water at 100℃; for 1h; Suzuki Coupling; Inert atmosphere; | 100% |
(3,4-difluorophenyl)boronic acid
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In tetrahydrofuran; water at 100℃; for 2h; Suzuki Coupling; Microwave irradiation; Inert atmosphere; Sealed tube; | 100% |
Conditions | Yield |
---|---|
Stage #1: 2,2-Dimethyl-1,3-propanediol; (3,4-difluorophenyl)boronic acid In diethyl ether at 20℃; for 1h; Stage #2: With calcium chloride at 20℃; for 1h; | 100% |
4-amino-8-bromo-N-propyl-cinnoline-3-carboxamide
(3,4-difluorophenyl)boronic acid
Conditions | Yield |
---|---|
98.7% |
para-nitrophenyl bromide
(3,4-difluorophenyl)boronic acid
3,4-difluoro-4'-nitro-1,1'-biphenyl
Conditions | Yield |
---|---|
With sodium carbonate In water at 25℃; for 6.5h; Suzuki Coupling; | 98% |
With sodium carbonate at 80℃; for 1.16667h; Catalytic behavior; Suzuki Coupling; | 97% |
With sodium carbonate at 100℃; for 0.75h; Suzuki-Miyaura Coupling; | 95% |
1-bromo-4-methoxy-benzene
(3,4-difluorophenyl)boronic acid
Conditions | Yield |
---|---|
With Ph2P(CH2CH2O)22CH3; triethylamine; palladium dichloride In water at 80℃; for 2h; Suzuki coupling; Inert atmosphere; | 98% |
With sodium carbonate at 100℃; for 2.5h; Suzuki-Miyaura Coupling; | 91% |
4-bromobenzenecarbonitrile
(3,4-difluorophenyl)boronic acid
3',4'-difluoro-(1,1'-biphenyl)-4-carbonitrile
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,2-dimethoxyethane Suzuki Coupling; Reflux; Inert atmosphere; | 98% |
With sodium carbonate at 80℃; for 1.5h; Catalytic behavior; Suzuki Coupling; | 97% |
With Ph2P(CH2CH2O)22CH3; triethylamine; palladium dichloride In water at 80℃; for 1h; Suzuki coupling; Inert atmosphere; | 96% |
(3,4-difluorophenyl)boronic acid
3,3’,4,4’-tetrafluorobiphenyl
Conditions | Yield |
---|---|
With air In N,N-dimethyl-formamide at 20℃; for 16h; Green chemistry; | 98% |
With copper fluorapatite In methanol at 20℃; for 2h; Green chemistry; | 93% |
With oxygen; potassium carbonate In water at 25℃; for 2h; Green chemistry; | 93% |
4-bromo-6-fluorobenzonitrile
(3,4-difluorophenyl)boronic acid
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,2-dimethoxyethane Suzuki Coupling; Reflux; Inert atmosphere; | 98% |
4-{3-[6-(3-bromo-5-dimethylcarbamoyl-phenoxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy}-butyric acid ethyl ester
(3,4-difluorophenyl)boronic acid
4-{3-[6-(5-dimethylcarbamoyl-3',4'-difluoro-biphenyl-3-yloxy)-hexyl]-2-(2-ethoxycarbonyl-ethyl)-phenoxy}-butyric acid ethyl ester
Conditions | Yield |
---|---|
With caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In 1,2-dimethoxyethane at 97℃; for 15h; Suzuki Coupling; | 97% |
(3,4-difluorophenyl)boronic acid
4-(carboxymethyl)-3',4'-difluorobiphenyl-3-carboxylic acid
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; water at 150℃; for 0.5h; Suzuki coupling; Inert atmosphere; Microwave irradiation; | 97% |
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; water at 150℃; for 0.5h; Suzuki Coupling; Microwave irradiation; |
8-bromo-[1,2,4]triazolo[1,5-a]pyridine-2-ylamine
(3,4-difluorophenyl)boronic acid
8-(3,4-difluoro-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine
Conditions | Yield |
---|---|
With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In 1,4-dioxane; water at 20 - 110℃; for 18h; | 97% |
With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In 1,4-dioxane; water at 110℃; for 18h; Suzuki Coupling; | 97% |
2,6-dibromo-4-nitroaniline
(3,4-difluorophenyl)boronic acid
2,6-bis(3,4-difluorophenyl)-4-nitroaniline
Conditions | Yield |
---|---|
With potassium phosphate tribasic heptahydrate; palladium diacetate In water; N,N-dimethyl-formamide at 80℃; for 0.416667h; Suzuki Coupling; | 97% |
1-bromo-4-(trans-4-pentylcyclohexyl)benzene
(3,4-difluorophenyl)boronic acid
3,4-difluoro-4'-(4-pentylcyclohexyl)-1,1'-biphenyl
Conditions | Yield |
---|---|
With 5%-palladium/activated carbon; potassium carbonate In ethanol; water at 80℃; for 0.5h; Suzuki Coupling; | 97% |
8-bromo-N-(2-(methylsulfonyl)ethyl)-1,6-naphthyridine-2-carboxamide
(3,4-difluorophenyl)boronic acid
8-(3,4-difluorophenyl)-N-(2-(methylsulfonyl)ethyl)-1,6-naphthyridine-2-carboxamide
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate In 1,4-dioxane; water at 80℃; for 1h; | 97% |
iodobenzene
(3,4-difluorophenyl)boronic acid
3,4‐difluoro‐1,1′‐biphenyl
Conditions | Yield |
---|---|
With sodium carbonate at 100℃; for 0.666667h; Suzuki-Miyaura Coupling; | 97% |
With sodium carbonate at 80℃; for 0.833333h; Catalytic behavior; Suzuki Coupling; | 97% |
With sodium carbonate at 80℃; for 1.41667h; Kinetics; Suzuki Coupling; Green chemistry; | 96% |
(3,4-difluorophenyl)boronic acid
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,2-dimethoxyethane; water at 100℃; for 1h; Inert atmosphere; | 97% |
4-(4-propylcyclohexyl)-1-bromobenzene
(3,4-difluorophenyl)boronic acid
Conditions | Yield |
---|---|
With potassium phosphate; [Pd(Ph2PCH2CH(CH3)O)2] In tetrahydrofuran; water at 20℃; for 5h; Suzuki cross-coupling reaction; | 96% |
With potassium fluoride; [Ph2P(CH2)2NH2]2PdCl2 In tetrahydrofuran; water at 25 - 27℃; for 5h; Suzuki cross-coupling reaction; | 96% |
With potassium phosphate; cis-bis((diphenylphosphino)acetate-κ2P,O)palladium(II) In tetrahydrofuran at 25 - 27℃; for 5h; Suzuki coupling; | 91% |
4-chloro-8-(2,6-difluorophenyl)-2-{[2-hydroxy-1-(hydroxy-methyl)ethyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one
(3,4-difluorophenyl)boronic acid
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 150℃; for 0.25h; Suzuki cross-coupling; Irradiation; microwave; | 96% |
4-Bromothiophen-2-aldehyde
(3,4-difluorophenyl)boronic acid
4-(3,4-difluorophenyl)thiophene-2-carbaldehyde
Conditions | Yield |
---|---|
With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) In ethanol; water; toluene for 16h; Suzuki cross-coupling; Heating; | 96% |
o-cyanobromobenzene
(3,4-difluorophenyl)boronic acid
3',4'-difluoro-[1,1'-biphenyl]-2-carbonitrile
Conditions | Yield |
---|---|
With 5%-palladium/activated carbon; potassium carbonate In ethanol; water at 80℃; for 0.666667h; Suzuki Coupling; | 96% |
With Ph2P(CH2CH2O)22CH3; triethylamine; palladium dichloride In water at 80℃; for 2h; Suzuki coupling; Inert atmosphere; | 95% |
Conditions | Yield |
---|---|
With sodium hydroxide In water for 2h; Reflux; | 96% |
2,6-dibromoaniline
(3,4-difluorophenyl)boronic acid
2,6-bis(3,4-difluorophenyl)aniline
Conditions | Yield |
---|---|
With potassium phosphate tribasic heptahydrate; palladium diacetate In water; N,N-dimethyl-formamide at 80℃; for 1.08333h; Suzuki Coupling; | 96% |
methyl 3-bromo-4-methylbenzoate
(3,4-difluorophenyl)boronic acid
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In N,N-dimethyl-formamide at 100℃; for 24h; Inert atmosphere; | 96% |
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In N,N-dimethyl-formamide at 100℃; for 24h; Inert atmosphere; | 96% |
bromobenzene
(3,4-difluorophenyl)boronic acid
3,4‐difluoro‐1,1′‐biphenyl
Conditions | Yield |
---|---|
With sodium carbonate at 80℃; for 1.16667h; Catalytic behavior; Suzuki Coupling; | 96% |
With sodium carbonate at 100℃; for 0.5h; Suzuki-Miyaura Coupling; | 95% |
With sodium carbonate In water at 25℃; for 7h; Suzuki Coupling; | 91% |
4-tolyl iodide
(3,4-difluorophenyl)boronic acid
Conditions | Yield |
---|---|
With sodium carbonate at 80℃; for 1.25h; Catalytic behavior; Suzuki Coupling; | 96% |
With sodium carbonate at 80℃; for 1.5h; Kinetics; Suzuki Coupling; Green chemistry; | 92% |
Conditions | Yield |
---|---|
With sodium carbonate at 80℃; for 1.16667h; Kinetics; Suzuki Coupling; Green chemistry; | 96% |
With sodium carbonate at 80℃; for 1.16667h; Catalytic behavior; Suzuki Coupling; | 87% |
2-methoxy-5-bromopyridine
(3,4-difluorophenyl)boronic acid
Conditions | Yield |
---|---|
With O4P(3-)*3K(1+)*5H2O; palladium dichloride In water; N,N-dimethyl-formamide at 20℃; for 24h; | 96% |
2-(4-bromophenyl]pyridine
(3,4-difluorophenyl)boronic acid
Conditions | Yield |
---|---|
With palladium diacetate; potassium carbonate In ethanol; water at 80℃; | 95.6% |
(3,4-difluorophenyl)boronic acid
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate In 1,4-dioxane; water at 110℃; for 12h; Inert atmosphere; | 95.04% |
Molecule structure of 3.4-Difloromethylboronic acid (CAS NO.168267-41-2):
IUPAC Name: (3,4-Difluorophenyl)boronic acid
Molecular Weight: 157.910506 g/mol
Molecular Formula: C6H5BF2O2
Density: 1.35 g/cm3
Melting Point: 289-290 °C
Boiling Point: 251 °C at 760 mmHg
Flash Point: 105.6 °C
Index of Refraction: 1.485
Molar Refractivity: 33.51 cm3
Molar Volume: 116.7 cm3
Surface Tension: 36.1 dyne/cm
Enthalpy of Vaporization: 51.6 kJ/mol
Vapour Pressure: 0.011 mmHg at 25 °C
Storage Temp.: refrigerator (+4 °C)
H-Bond Donor: 2
H-Bond Acceptor: 4
Rotatable Bond Count: 1
Exact Mass: 158.035066
MonoIsotopic Mass: 158.035066
Topological Polar Surface Area: 40.5
Heavy Atom Count: 11
Canonical SMILES: B(C1=CC(=C(C=C1)F)F)(O)O
InChI: InChI=1S/C6H5BF2O2/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3,10-11H
InChIKey: RMGYQBHKEWWTOY-UHFFFAOYSA-N
Product Categories: Fluorin-contained phenyl boronic acid series; HALIDE; blocks; BoronicAcids; FluoroCompounds; Substituted Boronic Acids; Boronic Acid; Aryl; Halogenated; Organoborons; Boronic Acids; Boronic Acids and Derivatives; Boronic Acids
3.4-Difloromethylboronic acid (CAS NO.168267-41-2) is used as intermediates of liquid crystals.
Hazard Codes: Xn, Xi
Risk Statements: 36/37/38-22
R36/37/38:Irritating to eyes, respiratory system and skin.
R22:Harmful if swallowed.
Safety Statements: 37/39-26-36
S37/39:Wear suitable gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
Hazard Note: Irritant
3.4-Difloromethylboronic acid (CAS NO.168267-41-2) is also named as (2,4-Difluorophenyl)boronic acid ; Boronic acid, B-(2,4-difluorophenyl)- ; (2,4-Difluorophenyl)Boranediol ; 2,4-Difluorobenzeneboronic acid ; 2,4-Difluorophenylboronic acid . 3.4-Difloromethylboronic acid (CAS NO.168267-41-2) is white powder.
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View