6-Chloro-1,3-dimethyluracil supplier

Name
6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione
EINECS 230-205-2
CAS No. 6972-27-6
Article Data23
CAS DataBase
Density 1.43 g/cm³
Solubility soluble in water
Melting Point 109-113 °C
Formula C₆H₇ClN₂O₂
Boiling Point 224.6 °C at 760 mmHg
Molecular Weight 174.587
Flash Point 89.6 °C
Transport Information
Appearance white or light white crystal powder
Safety 26-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 6-chloro-1,3-dimethyl-pyrimidine-2,4-dione;1,3-Dimethyl-6-chlorouracil;6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione;6-Chloro-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione;
PSA 44.00000
LogP -0.26260

Synthetic route

: 769-42-6
1,3-dimethylbarbituric acid

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

Conditions

Conditions	Yield
With water; trichlorophosphate Heating;	93%
With water; trichlorophosphate for 6h; Reflux; Large scale;	92.3%
With trichlorophosphate

: 4270-27-3
6-chlorouracil

: 74-83-9
methyl bromide

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

Conditions

Conditions	Yield
With sodium hydroxide; tetrabutylammomium bromide In dichloromethane at 20℃; for 48h;	90%

: 74-83-9
methyl bromide

: 4318-56-3
3-methyl-6-chlorouracil

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

Conditions

Conditions	Yield
With sodium hydroxide; tetrabutylammomium bromide In dichloromethane; water at 40℃; Alkylation;	90%

: 89-25-8
edaravone

: 35824-85-2
6-chloro-5-formyl-1,3-dimethyluracil

A: 6972-27-6
1,3-Dimethyl-6-chlorouracil

B: 4702-90-3
1-phenyl-3-methyl-4-(1-phenyl-3-methyl-5-oxo-4-pyrazolylidene)methylene-5-pyrazolone

Conditions

Conditions	Yield
With piperidine In ethanol at 20℃; for 0.5h;	A 75% B n/a

...Expand

: 4270-27-3
6-chlorouracil

: 74-88-4
methyl iodide

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 23℃; for 3h; Schlenk technique; Inert atmosphere;	52%

: 6320-15-6
6-chloro-2,4-dimethoxypyrimidine

: 74-88-4
methyl iodide

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

Conditions

Conditions	Yield
at 90℃;

: 6642-31-5
6-Amino-1,3-dimethylbarbituric acid

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aqueous HCl 2: POCl3 View Scheme

: 4270-27-3
6-chlorouracil

methyl halide: methyl halide

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 70℃; for 3h;

: 67-56-1
methanol

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

: 4097-20-5
6-methoxy-1,3-dimethyluracil

Conditions

Conditions	Yield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane; water for 2h; Ambient temperature;	100%

: 71-23-8
propan-1-ol

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

: 93767-18-1
1,3-Dimethyl-6-propoxy-1H-pyrimidine-2,4-dione

Conditions

Conditions	Yield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane; water for 2h; Ambient temperature;	100%

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

: 64-17-5
ethanol

: 93787-99-6
1,3-dimethyl-6-ethoxyuracil

Conditions

Conditions	Yield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane; water for 2h; Ambient temperature;	100%
With sodium carbonate for 28h; Reflux;	96%

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

: 71-41-0
pentan-1-ol

: 93767-19-2
1,3-Dimethyl-6-pentyloxy-1H-pyrimidine-2,4-dione

Conditions

Conditions	Yield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane; water for 2h; Ambient temperature;	100%

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

: 107-18-6
allyl alcohol

: 93767-20-5
1,3-dimethyluracil-6-allyl ether

Conditions

Conditions	Yield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane; water for 1.5h; Ambient temperature;	100%
With sodium for 2h; Heating;	63.3%
With sodium at 30 - 40℃; for 0.5h;	57.2%

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

: 75-08-1
ethanethiol

: 35218-96-3
6-Ethylsulfanyl-1,3-dimethyl-1H-pyrimidine-2,4-dione

Conditions

Conditions	Yield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane; water for 2.5h; Ambient temperature;	100%

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

: 100-51-6
benzyl alcohol

: 93767-21-6
6-Benzyloxy-1,3-dimethyl-1H-pyrimidine-2,4-dione

Conditions

Conditions	Yield
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane; water for 2h; Ambient temperature;	100%

: 91-20-3
naphthalene

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

: 4097-20-5
6-methoxy-1,3-dimethyluracil

Conditions

Conditions	Yield
In methanol at 20℃; for 1h; UV-irradiation;	100%

: 563-79-1
2,3-Dimethyl-2-butene

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

: 82959-62-4
1,1,2,2,3,5-hexamethyl-1,2-dihydrocyclobutapyrimidine-4,6(3H,5H)-dione

Conditions

Conditions	Yield
In acetone Irradiation;	99%
In acetone at 20℃; for 2h; Cycloaddition; Photolysis;

: 110-89-4
piperidine

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

: 1,3-dimethyl-6-(piperidin-1-yl)pyrimidine-2,4(1H,3H)-dione

Conditions

Conditions	Yield
at 60℃; for 0.00833333h; microwave irradiation;	99%
In 1,4-dioxane at 100℃; for 2h;	98%
In dichloromethane for 1h; Ambient temperature;	85%
In water Heating;	59%
Stage #1: 1,3-Dimethyl-6-chlorouracil With (1,3,5-triaza-7-phosphaadamantan-1-ium-1-yl)butane-1-sulfonate; palladium diacetate In N,N-dimethyl-formamide for 0.0833333h; Schlenk technique; Inert atmosphere; Stage #2: piperidine With triethylamine In N,N-dimethyl-formamide at 23℃; for 2h; Schlenk technique; Inert atmosphere;	168 mg

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

: 124-41-4
sodium methylate

: 4097-20-5
6-methoxy-1,3-dimethyluracil

Conditions

Conditions	Yield
In methanol at 60℃; for 0.00833333h; microwave irradiation;	99%

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

: 62-53-3
aniline

: 7278-51-5
6-anilino-1,3-dimethyluracil

Conditions

Conditions	Yield
at 160℃; for 0.5h; microwave irradiation;	98%
In neat (no solvent) at 180℃; for 3h;	87%
In ethanol for 12h; Heating;	80%

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

: 1203-25-4
6-chloro-1,3-dimethyl-5-nitrouracil

Conditions

Conditions	Yield
With sulfuric acid; potassium nitrate 1.) 15 min, 7 deg C, 2.) 30 min, 20 deg C;	98%
With sulfuric acid; nitric acid at 5℃;
With nitric acid; sulfuric acid at 10℃; for 2h;

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

: 100-46-9
benzylamine

: 5770-49-0
6-(benzylamino)-1,3-dimethyluracil

Conditions

Conditions	Yield
at 130℃; for 0.05h; microwave irradiation;	98%
With triethylamine In 1,4-dioxane for 10h; Reflux;	87%

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

: 141-52-6
sodium ethanolate

: 93787-99-6
1,3-dimethyl-6-ethoxyuracil

Conditions

Conditions	Yield
In ethanol at 60℃; for 0.00833333h; microwave irradiation;	97%

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

: 106-40-1
4-bromo-aniline

: 64663-99-6
6-(4-bromo-anilino)-1,3-dimethyl-1H-pyrimidine-2,4-dione

Conditions

Conditions	Yield
In neat (no solvent) at 180℃; for 3h;	97%
at 180℃; for 3h;	70%

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

: 109-73-9
N-butylamine

: 5770-46-7
6-n-butylamino-1,3-dimethyluracil

Conditions

Conditions	Yield
In N,N-dimethyl-formamide for 18h; Reflux;	96%

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

: 74-89-5
methylamine

: 5770-42-3
1,3-dimethyl-6-methylamino-1H-pyrimidine-2,4-dione

Conditions

Conditions	Yield
In methanol for 16h; Large scale;	95%
With water
In water

: 35161-71-8
N-methylpropargylamine

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

: 94154-86-6
1,3-dimethyl-6-(N-methyl-N-propargyl)aminouracil

Conditions

Conditions	Yield
	95%
for 6h; Ambient temperature;	87.7%

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

: 103-67-3
benzyl-methyl-amine

: 1,3-dimethyl-6-(benzylmethylamino)uracil

Conditions

Conditions	Yield
at 130℃; for 0.0166667h; microwave irradiation;	94%

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

: 24388-23-6
2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole

: 42542-99-4
1,3-dimethyl-6-phenyluracil

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,2-dimethoxyethane; water for 16h; Suzuki-Miyaura coupling; Reflux;	94%

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

: 930-69-8
sodium thiophenolate

: 35218-98-5
1,3-dimethyl-6-phenylthiouracil

Conditions

Conditions	Yield
In 1-methyl-pyrrolidin-2-one at 60℃; for 0.00833333h; microwave irradiation;	93%

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

: 943783-06-0
methyl 2-(11-(3-(piperazin-1-yl)propylidene)-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate

: 943781-13-3
methyl 2-(11-(3-(4-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)piperazin-1-yl)propylidene)-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 80℃; for 7h;	93%

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

: 68536-76-5
1-(2,4-dichlorophenyl)oxy-4-chloro-but-2-yne

: 897935-82-9
6-[4-(2,4-dichloro-phenoxy)-but-2-ynylsulfanyl]-1,3-dimethyl-1H-pyrimidine-2,4-dione

Conditions

Conditions	Yield
Stage #1: 1,3-Dimethyl-6-chlorouracil With sodium hydrogensulfide In ethanol at 0℃; for 6h; Stage #2: 1-(2,4-dichlorophenyl)oxy-4-chloro-but-2-yne With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane; water at 20℃; for 12h;	92%

: 767289-08-7
N-(2-bromo-5-methoxybenzyl),N-methylamine

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

: 1148107-95-2
6-((2-bromo-5-methoxybenzyl)(methyl)amino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione

Conditions

Conditions	Yield
In ethanol Reflux;	92%

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

: 104-94-9
4-methoxy-aniline

: 58137-44-3
6-p-Methoxyphenylamino-1,3-dimethyluracil

Conditions

Conditions	Yield
In neat (no solvent) at 180℃; for 3h;	91%

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

: 42016-93-3
2-chloro-4-iodoaniline

: 1026989-89-8
C12H11ClIN3O2

Conditions

Conditions	Yield
Stage #1: 1,3-Dimethyl-6-chlorouracil; 2-chloro-4-iodoaniline With lithium hexamethyldisilazane In tetrahydrofuran at 0 - 5℃; for 0.833333h; Stage #2: With water; ammonium chloride In tetrahydrofuran	91%

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

: 92-87-5
p,p'-diaminobiphenyl

: 1448799-77-6
6,6'-[biphenyl-4,4'-diyldi(imino)]bis(1,3-dimethylpyrimidine-2,4(1H,3H)-dione)

Conditions

Conditions	Yield
With quinoline at 180℃; for 3h;	91%

: 123-75-1
pyrrolidine

: 6972-27-6
1,3-Dimethyl-6-chlorouracil

: 74151-85-2
N,N-dimethyl-6-pyrrolidino uracil

Conditions

Conditions	Yield
In dichloromethane for 1h; Ambient temperature;	90%
In ethanol Ambient temperature;

6-Chloro-1,3-dimethyluracil Chemical Properties

Molecular structure of 6-Chloro-1,3-dimethyluracil (CAS NO.6972-27-6) is:

Product Name: 6-Chloro-1,3-dimethyluracil
CAS Registry Number: 6972-27-6
IUPAC Name: 6-chloro-1,3-dimethylpyrimidine-2,4-dione
Molecular Weight: 174.58498 [g/mol]
Molecular Formula: C₆H₇ClN₂O₂
EINECS: 230-205-2
XLogP3-AA: 0.2
H-Bond Donor: 0
H-Bond Acceptor: 2
Melting Point: 109-113 °C
Surface Tension: 51.8 dyne/cm
Density: 1.43 g/cm³
Flash Point: 89.6 °C
Enthalpy of Vaporization: 46.11 kJ/mol
Boiling Point: 224.6 °C at 760 mmHg
Vapour Pressure: 0.0906 mmHg at 25°C
Water Solubility: soluble
Product Categories: Biochemistry ;Nucleobases and their analogs ;Nucleosides, Nucleotides & Related Reagents ;Biochemicals and Reagents ;Nucleoside Analogs ;Nucleosides, Nucleotides, Oligonucleotides

6-Chloro-1,3-dimethyluracil Safety Profile

Safty information about 6-Chloro-1,3-dimethyluracil (CAS NO.6972-27-6) is:
Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 37/39-26
S37/39:Wear suitable gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3

6-Chloro-1,3-dimethyluracil Specification

6-Chloro-1,3-dimethyluracil , its cas register number is 6972-27-6. It also can be called EINECS 230-205-2 . And, it is a white to light yellow flakes or powder.
First Aid Measures:
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion: Get medical aid. Wash mouth out with water.
Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Handling and Storage:
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage: Store in a cool, dry place. Store in a tightly closed container.

Product Name

6-Chloro-1,3-dimethyl-2,4-(1H,3H)-pyrimidinedione

Synthetic route

6-Chloro-1,3-dimethyluracil Chemical Properties

6-Chloro-1,3-dimethyluracil Safety Profile

6-Chloro-1,3-dimethyluracil Specification

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