Conditions | Yield |
---|---|
With trichloroacetonitrile; triphenylphosphine In dichloromethane for 1h; Heating; | 100% |
With thionyl chloride | 99% |
With 2,2,4,4,6,6-hexachloro-1,3,5-triaza-2,4,6-triphosphorine; potassium chloride at 25℃; for 0.0333333h; Neat (no solvent); | 95% |
Conditions | Yield |
---|---|
With N-chloro-succinimide; ammonium chloride In water; acetonitrile at 0℃; for 0.333333h; pH=0 - 2; | 100% |
Conditions | Yield |
---|---|
With hydrogenchloride In water | A 100% B 100% |
Conditions | Yield |
---|---|
With thionyl chloride; dihydrogen peroxide In water; acetonitrile at 25℃; for 0.0166667h; | 99% |
With dihydrogen peroxide; zirconium(IV) chloride In water; acetonitrile at 25℃; for 0.0166667h; | 98% |
With N,N,N',N'-tetrachlorobenzene-1,3-disulphonamide; tetrabutyl-ammonium chloride; water In acetonitrile at 0 - 20℃; for 0.333333h; | 98% |
Conditions | Yield |
---|---|
With N,N,N',N'-tetrachlorobenzene-1,3-disulphonamide; tetrabutyl-ammonium chloride; water In acetonitrile at 0 - 20℃; for 0.333333h; | 99% |
With trichloroisocyanuric acid; tetrabutylammomium bromide; water In acetonitrile at 0 - 20℃; for 0.333333h; | 99% |
With dihydrogen peroxide; trichlorophosphate In water at 25℃; for 0.5h; Micellar solution; | 96% |
methyl carbamothioic acid S-phenyl ester
benzenesulfonyl chloride
Conditions | Yield |
---|---|
With hydrogenchloride; N-chloro-succinimide In acetonitrile at 10℃; | 96.6% |
Conditions | Yield |
---|---|
With hydrogenchloride; N-chloro-succinimide In acetonitrile at 10℃; for 0.166667h; | 96.3% |
Conditions | Yield |
---|---|
With hydrogenchloride; iodosylbenzene for 0.0833333h; | 96% |
With hydrogenchloride; iodosylbenzene for 0.0833333h; Chlorination; oxidation; | 96% |
With 1,3-dichloro-5,5-dimethylhydantoin; acetic acid In dichloromethane; water at 0 - 5℃; Inert atmosphere; | 90% |
With N-chloro-succinimide In dichloromethane; benzyl alcohol for 18h; Ambient temperature; | 62% |
Conditions | Yield |
---|---|
With 1,3,5-trichloro-2,4,6-triazine; 18-crown-6 ether In acetone for 20h; Heating; | 94% |
Stage #1: sodium phenylsulfonate With potassium phosphate; bis(trichloromethyl) carbonate In dichloromethane at 0 - 5℃; for 0.0833333h; Stage #2: With triethylamine In dichloromethane at 20℃; for 0.5h; | 91% |
With phosphorus pentachloride Man giesst in Wasser und destilliert das hierbei sich abscheidende Benzolsulfochlorid mit Wasser unter vermindertem Druck; |
methoxymethyl phenyl sulfide
benzenesulfonyl chloride
Conditions | Yield |
---|---|
With water; chlorine In dichloromethane at 5 - 10℃; for 1h; | 94% |
toluene-4-sulfonic acid phenyl ester
phenylboronic acid
benzenesulfonyl chloride
Conditions | Yield |
---|---|
With phenylchlorosulfate; C43H43NO3PPdS; sodium carbonate In acetone at 20 - 50℃; Inert atmosphere; Sealed tube; | 90% |
S-Phenyl benzenethiosulfonate
benzenesulfenyl chloride
A
benzenesulfonyl chloride
B
diphenyldisulfane
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 115℃; for 24h; Mechanism; | A n/a B 88.7% |
Conditions | Yield |
---|---|
With N-chloro-succinimide In water; acetonitrile at 35℃; for 0.25h; Solvent; Temperature; Reagent/catalyst; | A 78% B 17% |
Conditions | Yield |
---|---|
With potassium chloride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In water at 20℃; for 10h; Reagent/catalyst; | A 22% B 68% |
Conditions | Yield |
---|---|
With hydrogenchloride; iodosylbenzene for 0.0833333h; | 56% |
benzenesulfonyl chloride
Conditions | Yield |
---|---|
With hydrogenchloride; iodosylbenzene for 0.0833333h; Chlorination; oxidation; | 56% |
Conditions | Yield |
---|---|
Stage #1: aniline With hydrogenchloride; acetic acid Stage #2: With sodium nitrite In water at -10 - -5℃; for 0.75h; Stage #3: With hydrogenchloride; sulfur dioxide; acetic acid; copper(l) chloride In water at 10℃; for 0.5h; | 53% |
With hydrogenchloride; sodium nitrite In acetic acid | |
Stage #1: aniline With hydrogenchloride; sodium nitrite Stage #2: With sulfur dioxide; copper(l) chloride In acetone |
methyl-phenyl-thioether
A
Methyl phenyl sulfone
B
benzenesulfonyl chloride
Conditions | Yield |
---|---|
With hydrogenchloride; iodosylbenzene for 0.0833333h; | A 47% B 4% |
With hydrogenchloride; iodosylbenzene for 0.0833333h; Chlorination; oxidation; | A 47% B 4% |
N-chloro-succinimide
Benzyl phenyl sulfide
benzyl alcohol
A
Succinimide
B
benzyl chloride
C
benzenesulfonyl chloride
Conditions | Yield |
---|---|
In dichloromethane for 18h; Product distribution; Ambient temperature; | A n/a B n/a C 42% |
nitrostyrene
benzene diazonium chloride
A
(2-nitro-1-(phenylsulfonyl)ethyl)benzene
B
benzenesulfonyl chloride
Conditions | Yield |
---|---|
With sulfur dioxide In acetic acid; acetone at 15 - 20℃; | A 35% B n/a |
Conditions | Yield |
---|---|
With chlorosulfonic acid at 20℃; Cooling with ice; | 34% |
With chlorosulfonic acid; sulfuric acid | |
With chlorosulfonic acid; sodium chloride |
N-chloro-succinimide
ethanol
Benzyl phenyl sulfide
A
Succinimide
B
ethyl benzenesulfinate
C
benzyl chloride
D
benzenesulfonyl chloride
Conditions | Yield |
---|---|
In dichloromethane for 18h; Product distribution; Ambient temperature; | A n/a B 30% C n/a D n/a |
Conditions | Yield |
---|---|
With thionyl chloride; tris(bipyridine)ruthenium(II) dichloride hexahydrate In water; acetonitrile at 20℃; for 20h; Sealed tube; Irradiation; | 30% |
benzene diazonium chloride
(E)-benzalacetone
A
4-benzenesulfonyl-4-phenyl-butan-2-one
B
benzenesulfonyl chloride
Conditions | Yield |
---|---|
With sulfur dioxide In acetic acid; acetone | A 14% B n/a |
N,N-dimethyl-aniline
A
N,N,N',N'-tetramethylbenzidine
B
4-fluoro-N,N-dimethylaniline
C
2-fluoro-N,N-dimethylaniline
D
1-chloro-2-(dimethylamino)benzene
E
4-(methylamino)benzaldehyde
F
4,4'-methylene-bis(N,N-dimethylaniline)
G
4-dimethylamino-benzaldehyde
H
benzenesulfonyl chloride
Conditions | Yield |
---|---|
With zirconium(IV) chloride; N-fluorobis(benzenesulfon)imide In chloroform for 5h; Reflux; | A n/a B n/a C n/a D n/a E n/a F n/a G n/a H 6% |
Conditions | Yield |
---|---|
at 200℃; |
Conditions | Yield |
---|---|
With chlorine |
Conditions | Yield |
---|---|
With phosphorus pentachloride at 160 - 170℃; | |
With chlorine at 120 - 130℃; |
N,N-dimethylbenzenesulfonamide
benzenesulfonyl chloride
Conditions | Yield |
---|---|
With chlorosulfonic acid at 130 - 150℃; |
1-indoline
benzenesulfonyl chloride
1-benzenesulfonyl-2,3-dihydro-1H-indole
Conditions | Yield |
---|---|
With triethylamine In 1,2-dichloro-ethane at 0 - 20℃; for 1h; | 100% |
With potassium trimethylsilonate In water at 20℃; for 0.5h; Concentration; Inert atmosphere; | 97% |
With dmap; triethylamine In dichloromethane at 0 - 20℃; | 96% |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane at -25 - 20℃; Inert atmosphere; | 100% |
With N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide In tetrahydrofuran at 20℃; for 1h; | 80% |
With picoline In dichloromethane at 20℃; for 1h; | 71% |
2-methoxy-phenylamine
benzenesulfonyl chloride
N-(2-methoxyphenyl)benzenesulfonamide
Conditions | Yield |
---|---|
With pyridine for 12h; Ambient temperature; | 100% |
With sodium hydroxide at 20℃; for 1h; Addition; | 85% |
51% |
4-nitro-aniline
benzenesulfonyl chloride
N-(4-nitrophenyl)benzenesulfonamide
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 20℃; for 24h; | 100% |
With pyridine In dichloromethane at 20℃; | 92% |
With pyridine for 13h; Ambient temperature; | 83% |
Conditions | Yield |
---|---|
With pyridine at 0 - 25℃; | 100% |
With pyridine at 20℃; | 98% |
With Fe3O4-supported (diisopropylamino)acetamide In dichloromethane at 25℃; | 98% |
Conditions | Yield |
---|---|
Stage #1: benzenesulfonyl chloride; p-aminoethylbenzoate With pyridine for 18h; Stage #2: With ammonia In methanol at 90℃; for 0.5h; Microwave irradiation; | 100% |
With pyridine In tetrahydrofuran at 20℃; for 1.5h; | 100% |
With pyridine at 5 - 20℃; for 1h; sulfonylation; | 70% |
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 20℃; for 3h; | 100% |
86% | |
With pyridine for 4h; Heating; | 81% |
Conditions | Yield |
---|---|
With triethylamine In dichloromethane 1) 0 deg C, 1 h, 2) room temperature; | 100% |
With sodium hydroxide In water at 25℃; for 2h; pH 9.6; | 99.9% |
With Fe3O4-supported (diisopropylamino)acetamide In dichloromethane at 25℃; | 98% |
benzenesulfonyl chloride
3,4-dimethoxyaniline
N-(3,4-dimethoxyphenyl)benzenesulfonamide
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 20℃; for 0.0833333h; | 100% |
With pyridine; dmap In tetrahydrofuran Ambient temperature; | 65% |
With potassium hydroxide at 30 - 40℃; zuletzt bei 75grad; | |
With sodium hydroxide In acetone |
Conditions | Yield |
---|---|
With trimethylsilyl iodide In dichloromethane at 25℃; for 16h; | 100% |
With tungsten(VI) chloride; sodium iodide In acetonitrile for 16h; Ambient temperature; | 97% |
With Silphos; iodine In acetonitrile for 10h; Heating; | 96% |
Conditions | Yield |
---|---|
With picoline In dichloromethane at 20℃; for 1h; | 100% |
With pyridine In dichloromethane at 0 - 20℃; | 85% |
With pyridine |
Conditions | Yield |
---|---|
In chloroform at 0℃; | 100% |
With hydrogenchloride In dichloromethane at 0 - 20℃; for 0.666667h; | 97% |
With triethylamine In dichloromethane at 20℃; | 95% |
piperidin-2-one
benzenesulfonyl chloride
1-Benzenesulfonyl-3,4,5,6-tetrahydropyridin-2-one
Conditions | Yield |
---|---|
Stage #1: piperidin-2-one With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere; Stage #2: benzenesulfonyl chloride In tetrahydrofuran; hexane at -78℃; for 4h; Inert atmosphere; | 100% |
With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 3h; | 94% |
With n-butyllithium 1.) THF, hexane, -60 deg C, 20 min, 2.) THF, hexane, from -60 deg C to 0 deg C, 2.5 h; Yield given. Multistep reaction; |
Conditions | Yield |
---|---|
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In dichloromethane at 0 - 20℃; for 3h; | 100% |
Stage #1: indole With sodium hydride In tetrahydrofuran for 0.25h; Cooling with ice bath; Stage #2: benzenesulfonyl chloride In tetrahydrofuran at 20℃; | 100% |
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In dichloromethane | 99% |
Conditions | Yield |
---|---|
With potassium hydroxide; 1-butyl-3-methylimidazolium Tetrafluoroborate at 80℃; for 1h; | 100% |
With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide In dichloromethane; water at 20℃; Inert atmosphere; Cooling; | 99% |
With n-butyllithium In tetrahydrofuran; hexane at -78 - 20℃; for 18.5h; | 98% |
5,6-methylenedioxyindole
benzenesulfonyl chloride
5-(benzenesulfonyl)-[1,3]dioxolo[4,5-f]indole
Conditions | Yield |
---|---|
With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide In dichloromethane at 20℃; Cooling with ice; | 100% |
With n-butyllithium 1.) THF, hexane, from -70 deg C to 0 deg C, 45 min, 2.) from -70 deg C to room temperature, 2 h; Multistep reaction; |
5-chloro-1H-indole
benzenesulfonyl chloride
5-chloro-1-(phenylsulfonyl)-1H-indole
Conditions | Yield |
---|---|
With dmap; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 18h; Reflux; | 100% |
Stage #1: 5-chloro-1H-indole With sodium hydride In tetrahydrofuran at 20℃; for 1h; Stage #2: benzenesulfonyl chloride In tetrahydrofuran for 1h; | 96% |
Stage #1: 5-chloro-1H-indole With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.333333h; Inert atmosphere; Stage #2: benzenesulfonyl chloride In tetrahydrofuran; mineral oil at 0 - 20℃; Inert atmosphere; | 96.3% |
4-hydroxy-benzaldehyde
benzenesulfonyl chloride
4-hydroxybenzaldehyde benzenesulfonate ester
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere; | 100% |
With triethylamine In dichloromethane at 0 - 20℃; for 2h; Inert atmosphere; | 99% |
With triethylamine In dichloromethane at 20℃; for 2h; | 98% |
2-methyl-1-buten-4-ol
benzenesulfonyl chloride
3-methyl-3-butenyl-1-benznesulfonate
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 0℃; for 4h; | 100% |
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 4.33333h; |
4-methyl-5-nitrophenol
benzenesulfonyl chloride
4-benzenesulfonyloxy-2-nitrotoluene
Conditions | Yield |
---|---|
With potassium carbonate In acetone for 2h; | 100% |
2-(3-methoxyanilino)acetaldehyde diethyl acetal
benzenesulfonyl chloride
N-(2,2-diethoxyethyl)-N-(3-methoxyphenyl)-benzene-sulfonamide
Conditions | Yield |
---|---|
With pyridine In dichloromethane 1.) 0 deg C, 1 h, 2.) 25 deg C, overnight; | 100% |
1-benzenesulfonamido-2,4-diaminonaphthalene
benzenesulfonyl chloride
1,2,4-tris(benzenesulfonamido)naphthalene
Conditions | Yield |
---|---|
With pyridine for 10h; | 100% |
N-(5-hexen-1-yl)aniline
benzenesulfonyl chloride
N-(hex-5-enyl)-N-phenylbenzenesulfonamide
Conditions | Yield |
---|---|
In pyridine for 10h; Heating; | 100% |
R-(+)-4-methyl-6-(tert-butyldimethylsiloxy)-1-hexanol
benzenesulfonyl chloride
R-(+)-4-methyl-6-(tert-butyldimethylsiloxy)-1-hexyl benzenesulphonate
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane for 3h; Ambient temperature; | 100% |
Conditions | Yield |
---|---|
With sodium carbonate In water for 5h; | 100% |
With sodium carbonate In water for 4h; | 100% |
With sodium carbonate In water at -5 - 20℃; for 4h; Inert atmosphere; | 100% |
5-Hydroxy-2-methylpyridine
benzenesulfonyl chloride
5-(benzenesulfonyloxy)-2-methylpyridine
Conditions | Yield |
---|---|
With triethylamine In dichloromethane | 100% |
With triethylamine In dichloromethane at 0℃; for 2h; | 95% |
With triethylamine |
L-phenylalanine
benzenesulfonyl chloride
Nα-benzenesulfonyl-L-phenylalanine
Conditions | Yield |
---|---|
With sodium carbonate In water for 5h; | 100% |
With sodium carbonate In water for 4h; | 100% |
With sodium hydroxide for 2h; Ambient temperature; pH=10; | |
With sodium hydroxide for 2.5h; Ambient temperature; | |
With N-ethyl-N,N-diisopropylamine; sodium hydroxide In acetone at 0 - 20℃; for 6h; Inert atmosphere; |
Conditions | Yield |
---|---|
With triethylamine In ethyl acetate at 20℃; Ring cleavage; | 100% |
benzenesulfonyl chloride
Conditions | Yield |
---|---|
With triethylamine In ethyl acetate at 20℃; Ring cleavage; | 100% |
(+/-)-trans-2-butyl-5-heptylpyrrolidine
benzenesulfonyl chloride
(2R,5R)-1-Benzenesulfonyl-2-butyl-5-heptyl-pyrrolidine
Conditions | Yield |
---|---|
With sodium hydroxide In chloroform Substitution; | 100% |
Product Name: Benzenesulfonyl chloride (CAS NO.98-09-9)
IUPAC Name: Benzenesulfonyl chloride
CAS NO: 98-09-9
Molecular Formula: C6H5ClO2S
Molecular Weight :176.6207
Molecular Structure :
EINECS: 202-636-6
Index of Refraction: 1.553
Surface Tension: 42.6 dyne/cm
Density: 1.4 g/cm3
Flash Point: 105.9 °C
Enthalpy of Vaporization: 46.9 kJ/mol
Boiling Point: 251.5 °C at 760 mmHg
Vapour Pressure: 0.0324 mmHg at 25°C
Melting point: 14.5 °C
Water Solubility: may decompose
Sensitive : Moisture Sensitive
Product Categories: Pharmaceutical Intermediates; Organics; Sulfonyl Halides; Sulfonyl HalidesDerivatization Reagents; Derivatization Reagents HPLC; Organic Building Blocks; Sulfur Compounds; UV-VIS;A-B, Puriss p.a.; Analytical Reagents for General Use; Puriss p.a.
Benzenesulfonyl chloride (CAS NO.98-09-9) is used for intermediates of medicines and dyes , mainly forsulfa drugs, is also used to identify a variety of amine.
Benzene and Chlorosulfonic acid for reaction in 1:3 (mol) at 20 ~ 30°C about 2h, which are crude Benzene chloride, Benzenesulfonyl chloride (CAS NO.98-09-9) is obtained by the refining of the crude product.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LD50 | oral | 828mg/kg (828mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 36(6), Pg. 19, 1971. | |
mouse | LD50 | oral | 828mg/kg (828mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 36(6), Pg. 19, 1971. | |
rabbit | LD50 | oral | 828mg/kg (828mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 36(6), Pg. 19, 1971. | |
rat | LCLo | inhalation | 1870mg/m3/1H (1870mg/m3) | SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Office of Toxic Substances Report. Vol. OTS0510391, |
rat | LD50 | intraperitoneal | 76mg/kg (76mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Medycyna Pracy. Industrial Medicine. Vol. 20, Pg. 513, 1969. |
rat | LD50 | oral | 1960mg/kg (1960mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Medycyna Pracy. Industrial Medicine. Vol. 20, Pg. 513, 1969. |
Poison by intraperitoneal route. A dangerous storage hazard. It may explode in a sealed bottle. Explosive reaction with dimethyl sulfoxide. Reacts vigorously with methyl formamide. When heated to decomposition it emits toxic fumes of Cl− and SOx. See also SULFONATES.
Hazard Codes C
Risk Statements 20/22-34-42/43-29
R20/22:Harmful by inhalation and if swallowed.
R34:Causes burns.
R42/43:May cause sensitization by inhalation and skin contact.
R29:Contact with water liberates toxic gas.
Safety Statements 23-26-36/37/39-45
S23:Do not breathe vapour.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR UN 2225 8/PG 3
WGK Germany 1
RTECS DB8750000
F 21
HazardClass 8
PackingGroup III
Benzenesulfonyl chloride , its CAS NO. is 98-09-9, the synonyms are Benezenesulfochloride ; Benzene sulfonechloride .
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View