Conditions | Yield |
---|---|
[(cyclopentadienyl)bis(acetonitrile)(triphenylphosphine)ruthenium(II)] hexafluorophosphate In methanol at 25℃; for 12h; | 97% |
Conditions | Yield |
---|---|
With hydrogenchloride; calcium chloride at 100℃; for 72h; | 80% |
With hydrogenchloride | |
With hydrogenchloride | |
With hydrogenchloride; dodecatungstosilic acid In water at 20℃; under 760.051 Torr; for 2h; Reagent/catalyst; |
thiophene
4-Chlorobutanoyl chloride
A
γ-chlorobutyric acid
B
4-chloro-1-(thien-2-yl)-1-butanone
Conditions | Yield |
---|---|
aluminium trichloride; nitromethane In carbon disulfide for 3h; Ambient temperature; | A 17% B 75% |
Conditions | Yield |
---|---|
With copper(II) sulfate at 240℃; for 1h; | 65% |
Conditions | Yield |
---|---|
With hydrogenchloride; sodium nitrite | |
With hydrogenchloride; sodium nitrite |
Conditions | Yield |
---|---|
With hydrogenchloride |
N-nitroso-dihydro-2(3H)-pyrrolidinone
A
but-3-enoic acid
B
γ-chlorobutyric acid
Conditions | Yield |
---|---|
With hydrogenchloride |
Conditions | Yield |
---|---|
With nitric acid | |
With chromium(VI) oxide; sulfuric acid |
4-(4-nitrophenoxy)butanoic acid
γ-chlorobutyric acid
Conditions | Yield |
---|---|
Verseifen des entstandenen γ-Chlor-butyronitrils mit konz.Salzsaeure unter Druck und Ueberfuehren der gebildeten Saeuren in γ-Butyrolacton,danach Addition von Chlorwasserstoff; |
Conditions | Yield |
---|---|
With tetrachloromethane; sulfuryl dichloride; dibenzoyl peroxide im Dunkeln; |
Conditions | Yield |
---|---|
With hydrogenchloride; diethyl ether at 0℃; |
1,1,4-trichlorobut-1-ene
γ-chlorobutyric acid
Conditions | Yield |
---|---|
With sulfuric acid |
Conditions | Yield |
---|---|
With potassium fluoride; acetic acid |
Conditions | Yield |
---|---|
In gas at 360.1 - 390.2℃; under 49 - 209 Torr; Rate constant; Kinetics; Thermodynamic data; E(act); |
2-pyrrolidinon
hydrogenchloride
water
A
but-3-enoic acid
B
γ-chlorobutyric acid
chlorine
butyric acid
A
γ-chlorobutyric acid
B
3-chlorobutyric acid
C
2-chlorobutanoic acid
Conditions | Yield |
---|---|
Einwirkung von γ-Strahlen.Irradiation; | |
im Licht (λ: 350-400 nm).Irradiation; |
tetrachloromethane
sulfuryl dichloride
butyric acid
dibenzoyl peroxide
A
γ-chlorobutyric acid
B
3-chlorobutyric acid
C
2-chlorobutanoic acid
Conditions | Yield |
---|---|
im Dunkeln; | |
im Dunkeln; |
Conditions | Yield |
---|---|
With chlorine im UV-Licht; |
5-Chloro-dihydro-2(3H)-furanone
A
4-butanolide
B
γ-chlorobutyric acid
C
2-buten-4-olide
Conditions | Yield |
---|---|
With palladium on activated carbon at 130℃; under 760.051 Torr; for 4h; Reagent/catalyst; Temperature; |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane for 2h; | 100% |
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; Schlenk technique; Inert atmosphere; | 100% |
γ-chlorobutyric acid
tributylphosphine
tri-n-butyl(3-carboxypropyl)phosphonium chloride
Conditions | Yield |
---|---|
at 60℃; for 0.25h; Microwave irradiation; Inert atmosphere; | 99% |
Conditions | Yield |
---|---|
With thionyl chloride Heating; | 97% |
With thionyl chloride In benzene for 0.5h; Heating; water-bath; | 58% |
With thionyl chloride |
1-Butylimidazole
γ-chlorobutyric acid
1-butyl-3-(3-carboxypropyl)-1H-imidazol-3-ium chloride
Conditions | Yield |
---|---|
at 120℃; for 8h; | 96% |
Conditions | Yield |
---|---|
A n/a B 92.6% |
Conditions | Yield |
---|---|
With aluminium trichloride at 20 - 50℃; for 3h; Friedel-Crafts reaction; | 92% |
γ-chlorobutyric acid
5-methoxy-2-(3-phenylisoxazol-5-yl)phenol
4-(5-methoxy-2-(3-phenylisoxazol-5-yl)phenoxy)butanoic acid
Conditions | Yield |
---|---|
With potassium carbonate In acetone Williamson type O-alkylation; Reflux; | 90.65% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; Inert atmosphere; | 88% |
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; | 88% |
With dmap; dicyclohexyl-carbodiimide In dichloromethane |
Conditions | Yield |
---|---|
With titanium tetrachloride In neat (no solvent) at 100℃; for 6h; Inert atmosphere; | 86% |
Conditions | Yield |
---|---|
In acetonitrile at 80℃; for 48h; | 86% |
Conditions | Yield |
---|---|
With tetrabutylammonium tetrafluoroborate In methanol; acetonitrile at 20℃; for 6h; Inert atmosphere; Electrochemical reaction; | 85% |
γ-chlorobutyric acid
1-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-yl)-1-ethanol
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane for 13h; Reflux; | 83% |
Conditions | Yield |
---|---|
Stage #1: C82H125CoN15O15P With ammonium bromide; zinc In ethanol for 0.333333h; Inert atmosphere; Stage #2: γ-chlorobutyric acid In ethanol for 3h; Inert atmosphere; | 82% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; | 81.2% |
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 4h; | 81.2% |
Conditions | Yield |
---|---|
With sodium hydride In various solvent(s) 1.) 0 deg C, 30 min, 2.) r.t., 18 h; | 81% |
γ-chlorobutyric acid
4-azidobutanoic acid
Conditions | Yield |
---|---|
With sodium azide In water for 24h; Reflux; | 81% |
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; | 80.5% |
Conditions | Yield |
---|---|
In water; N,N-dimethyl-formamide | 80% |
In water; N,N-dimethyl-formamide | 80% |
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In hexane; water | 79% |
γ-chlorobutyric acid
triphenylphosphine
(3-carboxy-propyl)triphenylphosphonium chloride
Conditions | Yield |
---|---|
In toluene at 180℃; for 3h; | 78% |
In neat (no solvent) at 180℃; for 2h; | 61% |
γ-chlorobutyric acid
Conditions | Yield |
---|---|
With silver hexafluoroantimonate In trifluoroacetic acid at 20℃; for 3h; | 75% |
Conditions | Yield |
---|---|
With titanium(IV) dioxide In acetonitrile for 48h; Inert atmosphere; Irradiation; Cooling; | 74% |
γ-chlorobutyric acid
poly(methacrylic acid)
7-methoxycarbonyl-2-oxohexahydro-3,5-methano-2H-cyclopenta[b]furan-6-yl 4-(methacryloyloxy)butyrate
Conditions | Yield |
---|---|
With sodium iodide; triethylamine In N-methyl-acetamide; water | 73% |
γ-chlorobutyric acid
Conditions | Yield |
---|---|
With triethylamine Heating; | 70% |
γ-chlorobutyric acid
7-methoxycarbonyl-2-oxohexahydro-3,5-methano-2H-cyclopenta[b]furan-6-yl 4-chlorobutyrate
sodium methacrylate
7-methoxycarbonyl-2-oxohexahydro-3,5-methano-2H-cyclopenta[b]furan-6-yl 4-(methacryloyloxy)butyrate
Conditions | Yield |
---|---|
With sodium iodide In N-methyl-acetamide; water | 70% |
γ-chlorobutyric acid
N-methyl-p-toluenesulfonylamide
N-methyl-N-tosyl-4-chlorobutyramide
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 0 - 20℃; | 70% |
The Butanoic acid,4-chloro- is an organic compound with the formula C4H7ClO2. The IUPAC name of this chemical is 4-chlorobutanoic acid. With the CAS registry number 627-00-9, it is also named as 4-Chloro-n-butyric Acid. The product's categories are omega-Chlorocarboxylic Acids; omega-Functional Alkanols, Carboxylic Acids, Amines & Halides; C1 to C5; Carbonyl Compounds; Carboxylic Acids.
Physical properties about Butanoic acid,4-chloro- are: (1)D/LogP: 0.70; (2)ACD/LogD (pH 5.5): -0.33; (3)ACD/LogD (pH 7.4): -2.13; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 5.38; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 2; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 3; (11)Polar Surface Area: 26.3 Å2; (12)Index of Refraction: 1.449; (13)Molar Refractivity: 26.99 cm3; (14)Molar Volume: 100.5 cm3; (15)Polarizability: 10.7×10-24cm3; (16)Surface Tension: 39.1 dyne/cm; (17)Density: 1.218 g/cm3; (18)Flash Point: 101.1 °C; (19)Enthalpy of Vaporization: 60.65 kJ/mol; (20)Boiling Point: 310.6 °C at 760 mmHg; (21)Vapour Pressure: 0.000131 mmHg at 25°C.
Preparation of Butanoic acid,4-chloro-: this chemical can be prepared by dihydro-furan-2-one. This reaction will need reagent concentrated aqueous hydrochloric acid.
Uses of Butanoic acid,4-chloro-: it can be used to produce 4-chloro-butyryl chloride. It will need reagent thionyl chloride.
When you are using this chemical, please be cautious about it as the following:
It is harmful if swallowed. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Besides, this chemical can cause burns. When you are using it, wear suitable gloves and eye/face protection. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible).
You can still convert the following datas into molecular structure:
(1)SMILES: ClCCCC(=O)O
(2)InChI: InChI=1/C4H7ClO2/c5-3-1-2-4(6)7/h1-3H2,(H,6,7)
(3)InChIKey: IPLKGJHGWCVSOG-UHFFFAOYAC
(4)Std. InChI: InChI=1S/C4H7ClO2/c5-3-1-2-4(6)7/h1-3H2,(H,6,7)
(5)Std. InChIKey: IPLKGJHGWCVSOG-UHFFFAOYSA-N
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