Product Name

  • Name

    D(+)-2-Octanol

  • EINECS 228-213-6
  • CAS No. 6169-06-8
  • Article Data215
  • CAS DataBase
  • Density 0.822 g/mL at 25 °C(lit.)
  • Solubility 1 g/L (20 °C) in water
  • Melting Point -38oC
  • Formula C8H18O
  • Boiling Point 175 °C(lit.)
  • Molecular Weight 130.23
  • Flash Point 160 °F
  • Transport Information
  • Appearance Colorless to light yellow liquid
  • Safety 26-36-37/39
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 6169-06-8 (D(+)-2-Octanol)
  • Hazard Symbols IrritantXi
  • Synonyms d-Octan-2-ol;octan-2-ol;2-Octanol, (S)-;2-Octanol, (2S)-;(S)-(+)-2-Octanol;D-2-Octanol;
  • PSA 20.23000
  • LogP 2.33760

Synthetic route

(R)-2-octyl sulfate
74403-68-2

(R)-2-octyl sulfate

(S)-2-Octanol
6169-06-8

(S)-2-Octanol

Conditions
ConditionsYield
With His-tagged Pseudomonas sp. metallo-β-lactamase-type alkylsulfatase Pisa1; water; tris hydrochloride at 30℃; for 6h; pH=8.2; Enzymatic reaction; optical yield given as %ee; stereoselective reaction;100%
rac-octan-2-ol
4128-31-8

rac-octan-2-ol

(S)-2-Octanol
6169-06-8

(S)-2-Octanol

Conditions
ConditionsYield
With alcohol dehydrogenase from Lactobacillus kefir; alcohol dehydrogenase from Rhodococcus ruber DSM 44541; YcnD-oxidoreductase at 30℃; for 3h; pH=7.5; aq. buffer; Resolution of racemate; Enzymatic reaction; optical yield given as %ee; enantiospecific reaction;99%
With phosphate buffer; tributyrin for 140h; Ambient temperature;77%
hexyl-methyl-ketone
111-13-7

hexyl-methyl-ketone

(S)-2-Octanol
6169-06-8

(S)-2-Octanol

Conditions
ConditionsYield
With NAD; Co2+immobilized acetophenone reductase from Geotrichum candidum In aq. phosphate buffer; isopropyl alcohol at 30℃; for 3h; pH=7.2; Green chemistry; Enzymatic reaction; enantioselective reaction;99%
With glucose dehydrogenase; D-Glucose; alcohol dehydrogenase from Thermoanaerobacter sp.; NADPH In aq. buffer at 30℃; for 24h; pH=7.5; Concentration; Time; Ionic liquid; Green chemistry; Enzymatic reaction; enantioselective reaction;85%
With acetophenone reductase from Geotrichum candidum NBRC 4597; NAD In isopropyl alcohol at 30℃; for 3h; pH=7.2; Enzymatic reaction; enantioselective reaction;85%
(R)-2-octyl sulfate
74403-68-2

(R)-2-octyl sulfate

(S)-2-Octanol
6169-06-8

(S)-2-Octanol

Conditions
ConditionsYield
With His-tagged Pseudomonas sp. metallo-β-lactamase-type alkylsulfatase Pisa1; water; tris hydrochloride at 30℃; for 6h; pH=8.2; Enzymatic reaction; optical yield given as %ee; stereoselective reaction;100%
rac-octan-2-ol
4128-31-8

rac-octan-2-ol

(S)-2-Octanol
6169-06-8

(S)-2-Octanol

Conditions
ConditionsYield
With alcohol dehydrogenase from Lactobacillus kefir; alcohol dehydrogenase from Rhodococcus ruber DSM 44541; YcnD-oxidoreductase at 30℃; for 3h; pH=7.5; aq. buffer; Resolution of racemate; Enzymatic reaction; optical yield given as %ee; enantiospecific reaction;99%
With phosphate buffer; tributyrin for 140h; Ambient temperature;77%
hexyl-methyl-ketone
111-13-7

hexyl-methyl-ketone

(S)-2-Octanol
6169-06-8

(S)-2-Octanol

Conditions
ConditionsYield
With NAD; Co2+immobilized acetophenone reductase from Geotrichum candidum In aq. phosphate buffer; isopropyl alcohol at 30℃; for 3h; pH=7.2; Green chemistry; Enzymatic reaction; enantioselective reaction;99%
With glucose dehydrogenase; D-Glucose; alcohol dehydrogenase from Thermoanaerobacter sp.; NADPH In aq. buffer at 30℃; for 24h; pH=7.5; Concentration; Time; Ionic liquid; Green chemistry; Enzymatic reaction; enantioselective reaction;85%
With acetophenone reductase from Geotrichum candidum NBRC 4597; NAD In isopropyl alcohol at 30℃; for 3h; pH=7.2; Enzymatic reaction; enantioselective reaction;85%
rac-octan-2-ol
4128-31-8

rac-octan-2-ol

A

(S)-2-Octanol
6169-06-8

(S)-2-Octanol

B

(R)-Octan-2-ol
5978-70-1

(R)-Octan-2-ol

C

hexyl-methyl-ketone
111-13-7

hexyl-methyl-ketone

Conditions
ConditionsYield
With Arthrobacter atrocyaneus In N,N-dimethyl-formamide at 32℃; for 48h; Microbiological reaction; enantioselective reaction;A 94%
B n/a
C n/a
With lyophilised cells of Escherichia coli overexpressing the solvent-tolerant alcohol dehydrogenase from Rhodococcus ruber DSM44541 In aq. buffer at 30℃; for 24h; pH=7.5; Reagent/catalyst; Resolution of racemate; Enzymatic reaction;A n/a
B n/a
C n/a
With NADP In acetone at 50℃; for 22h; pH=8; Resolution of racemate;
...Expand
(R)-(+)-2-hydroxyoctyl tosylate
111221-79-5

(R)-(+)-2-hydroxyoctyl tosylate

(S)-2-Octanol
6169-06-8

(S)-2-Octanol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran93%
2-{[(S)-octan-7-yloxy]carbonyl}benzoic acid
6114-64-3

2-{[(S)-octan-7-yloxy]carbonyl}benzoic acid

(S)-2-Octanol
6169-06-8

(S)-2-Octanol

Conditions
ConditionsYield
With water; sodium hydroxide In methanol for 6h; Reflux; Inert atmosphere;87%
With potassium hydroxide Heating;3.4 g
rac-2-octyl sulfate
34760-88-8

rac-2-octyl sulfate

(S)-2-Octanol
6169-06-8

(S)-2-Octanol

Conditions
ConditionsYield
Stage #1: rac-2-octyl sulfate With His-tagged Pseudomonas sp. metallo-β-lactamase-type alkylsulfatase Pisa1; water; tris hydrochloride at 30℃; for 24h; pH=8.2; Resolution of racemate; Enzymatic reaction;
Stage #2: With water; toluene-4-sulfonic acid In 1,4-dioxane; tert-butyl methyl ether at 40℃; for 5h; optical yield given as %ee; stereoselective reaction;		87%
Multi-step reaction with 2 steps
1: His-tagged Pseudomonas sp. metallo-β-lactamase-type alkylsulfatase Pisa1; water; tris hydrochloride / 6 h / 30 °C / pH 8.2 / Resolution of racemate; Enzymatic reaction
2: water; toluene-4-sulfonic acid / 1,4-dioxane; tert-butyl methyl ether / 2 h / 40 °C
View Scheme
(R)-1-Benzylsulfanyl-octan-2-ol

(R)-1-Benzylsulfanyl-octan-2-ol

(S)-2-Octanol
6169-06-8

(S)-2-Octanol

Conditions
ConditionsYield
With sodium hypophosphite; Raney-Ni (W-2) In ethanol; water for 0.5h; Ambient temperature; pH=5.2;85%
With sodium hypophosphite; Raney Ni(W-2) In ethanol; water for 0.5h; Ambient temperature;75%
(S)-N-(oct-2-yloxy)-4-(p-chlorophenyl)-thiazole-2(3H)-thione
1200233-22-2

(S)-N-(oct-2-yloxy)-4-(p-chlorophenyl)-thiazole-2(3H)-thione

(S)-2-Octanol
6169-06-8

(S)-2-Octanol

Conditions
ConditionsYield
With tri-n-butyl-tin hydride In dichloromethane at 18℃; for 0.416667h; Inert atmosphere; Photolysis; enantioselective reaction;85%
(R)-1-Phenylsulfanyl-octan-2-ol
140421-08-5

(R)-1-Phenylsulfanyl-octan-2-ol

(S)-2-Octanol
6169-06-8

(S)-2-Octanol

Conditions
ConditionsYield
With sodium hypophosphite; Raney Ni(W-2) In ethanol; water for 0.5h; Ambient temperature;84%
With sodium hypophosphite; Raney-Ni (W-2) In ethanol; water for 0.5h; Ambient temperature; pH=5.2;84%
(R)-1-p-Tolylsulfanyl-octan-2-ol

(R)-1-p-Tolylsulfanyl-octan-2-ol

(S)-2-Octanol
6169-06-8

(S)-2-Octanol

Conditions
ConditionsYield
With sodium hypophosphite; Raney Ni(W-2) In ethanol; water for 0.5h; Ambient temperature;82%
With sodium hypophosphite; Raney-Ni (W-2) In ethanol; water for 0.5h; Ambient temperature; pH=5.2;82%
rac-octan-2-ol
4128-31-8

rac-octan-2-ol

A

(S)-2-Octanol
6169-06-8

(S)-2-Octanol

B

(+/-)-2-octyl acetoacetate
143913-51-3

(+/-)-2-octyl acetoacetate

Conditions
ConditionsYield
A 77%
B 75%
heptanal
111-71-7

heptanal

dimethyl zinc(II)
544-97-8

dimethyl zinc(II)

(S)-2-Octanol
6169-06-8

(S)-2-Octanol

Conditions
ConditionsYield
(1S,2R)-(-)-2-(N,N-di-n-butylamino)-1-phenylpropan-1-ol In hexane 1.) r.t., 20 min; 2.) 0 deg C, 16 h;70%
hexyl-methyl-ketone
111-13-7

hexyl-methyl-ketone

A

(S)-2-Octanol
6169-06-8

(S)-2-Octanol

B

(R)-Octan-2-ol
5978-70-1

(R)-Octan-2-ol

Conditions
ConditionsYield
With methanesulfonic acid; (R,R)-dihydroborate In hexane at -20℃; for 48h; Title compound not separated from byproducts;A n/a
B 68%
With hydrogen; tartaric acid-NaBr-mod. Raney nickel In tetrahydrofuran at 100℃; for 8h; Product distribution; enantioface hydrogenation with various carboxylic acids;
With hydrogen; TA-NaBr-MRNi In tetrahydrofuran at 60℃; under 66195.7 Torr; for 96h; Product distribution; RNi(prepared from 3.8 g of the alloy(Ni/Al=42/58))modified with 200 ml of aq. solution containing (R,R)-TA(2 g) and NaBr(12 g) at pH 3.2, 100 deg C for 1 h. hydrogenations of var. 2-alkanones, reactions at var. temperatures;
rac-octan-2-ol
4128-31-8

rac-octan-2-ol

benzeneacetic acid methyl ester
101-41-7

benzeneacetic acid methyl ester

A

(S)-2-Octanol
6169-06-8

(S)-2-Octanol

B

(R)-Octan-2-ol
5978-70-1

(R)-Octan-2-ol

C

(R)-2-octyl phenylacetate
92883-26-6

(R)-2-octyl phenylacetate

D

hexyl-methyl-ketone
111-13-7

hexyl-methyl-ketone

Conditions
ConditionsYield
With [(C4Ph4COHOCC4Ph4)(μ-H)][(CO)4Ru2]; Novozym(R) 435; 2,4-dimethylpentan-3-one In toluene at 70℃; under 142.511 Torr; for 40h;A n/a
B n/a
C 63%
D n/a
...Expand
(S)-N-(oct-2-yloxy)-pyridine-2(1H)-thione
1200233-00-6

(S)-N-(oct-2-yloxy)-pyridine-2(1H)-thione

(S)-2-Octanol
6169-06-8

(S)-2-Octanol

Conditions
ConditionsYield
With tri-n-butyl-tin hydride In dichloromethane at 18℃; for 0.0333333h; Inert atmosphere; Photolysis; enantioselective reaction;59%
rac-octan-2-ol
4128-31-8

rac-octan-2-ol

A

(S)-2-Octanol
6169-06-8

(S)-2-Octanol

B

(R)-Octan-2-ol
5978-70-1

(R)-Octan-2-ol

Conditions
ConditionsYield
With Candida antarctica lipase B; 1-(10-carboxydecyl)-3-methylimidazolium hexafluorophosphate; diisopropyl-carbodiimide In acetone at 40℃; for 2h; Resolution of racemate; Enzymatic reaction; enantioselective reaction;A 51%
B 35%
Title compound not separated from byproducts;
With sodium acetate In water at 40℃; enantioselective reaction;A n/a
B n/a
rac-octan-2-ol
4128-31-8

rac-octan-2-ol

2F6P(1-)*C30H52N4O3(2+)

2F6P(1-)*C30H52N4O3(2+)

A

(S)-2-Octanol
6169-06-8

(S)-2-Octanol

B

C23H43N2O2(1+)*F6P(1-)

C23H43N2O2(1+)*F6P(1-)

Conditions
ConditionsYield
With Candida antarctica lipase B In acetone at 35℃; for 3h; Resolution of racemate; Enzymatic reaction; enantioselective reaction;A 51%
B n/a
...Expand
vinyl acetate
108-05-4

vinyl acetate

rac-octan-2-ol
4128-31-8

rac-octan-2-ol

A

(S)-2-Octanol
6169-06-8

(S)-2-Octanol

B

(R)-2-octyl acetate
54712-18-4

(R)-2-octyl acetate

Conditions
ConditionsYield
With sol-gel encapsulated Candida antarctica lipase SP 525 at 20℃; for 17h;A 50%
B 47%
With 4 A molecular sieve; immobilized lipase PS In di-isopropyl ether at 30℃; for 15h;A 49%
B 48.7%
With immobilized lipase B from Candida antarctica In hexane at 32℃; for 1h; Resolution of racemate; Enzymatic reaction;A 40%
B 35%
...Expand
(S)-N-(oct-2-yloxy)-4-methylthiazole-2(3H)-thione
1200233-16-4

(S)-N-(oct-2-yloxy)-4-methylthiazole-2(3H)-thione

(S)-2-Octanol
6169-06-8

(S)-2-Octanol

Conditions
ConditionsYield
With tri-n-butyl-tin hydride In dichloromethane at 18℃; for 0.416667h; Inert atmosphere; Photolysis; enantioselective reaction;50%
(R)-octan-2-yl methanesulfonate
56772-63-5

(R)-octan-2-yl methanesulfonate

(S)-2-Octanol
6169-06-8

(S)-2-Octanol

Conditions
ConditionsYield
With sulfuric acid In tetrahydrofuran for 19h; Heating;46%
octan-2-yl acrylate
42928-85-8

octan-2-yl acrylate

A

(S)-2-Octanol
6169-06-8

(S)-2-Octanol

B

(R)-2-octanyl acrylate
15754-49-1

(R)-2-octanyl acrylate

Conditions
ConditionsYield
With Lipase Amano AK at 20℃; for 72h; pH=7; aq. phosphate buffer; Enzymatic reaction;A 42%
B 43%
oct-1-ene
111-66-0

oct-1-ene

(S)-2-Octanol
6169-06-8

(S)-2-Octanol

Conditions
ConditionsYield
With oleic acid hydratase from Elizabethkingia meningoseptica A248L mutant; water; hexanoic acid In dimethyl sulfoxide at 25℃; for 144h; pH=6; Reagent/catalyst; Enzymatic reaction; enantioselective reaction;22%
succinic acid methyl ester-(1-methyl-heptyl ester)

succinic acid methyl ester-(1-methyl-heptyl ester)

(S)-2-Octanol
6169-06-8

(S)-2-Octanol

Conditions
ConditionsYield
bei der Verseifung; succinic acid methyl ester--ester;
malonic acid ethyl ester-(1-methyl-heptyl ester)

malonic acid ethyl ester-(1-methyl-heptyl ester)

(S)-2-Octanol
6169-06-8

(S)-2-Octanol

Conditions
ConditionsYield
Hydrolysis; malonic acid ethyl ester--ester;
succinic acid ethyl ester-(1-methyl-heptyl ester)

succinic acid ethyl ester-(1-methyl-heptyl ester)

(S)-2-Octanol
6169-06-8

(S)-2-Octanol

Conditions
ConditionsYield
bei der Verseifung; succinic acid ethyl ester--ester;
malonic acid bis-(1-methyl-heptyl ester)
89837-79-6

malonic acid bis-(1-methyl-heptyl ester)

(S)-2-Octanol
6169-06-8

(S)-2-Octanol

Conditions
ConditionsYield
Hydrolysis; malonic acid di--ester;
bis(1-methylheptyl)butanedioate
29390-06-5

bis(1-methylheptyl)butanedioate

(S)-2-Octanol
6169-06-8

(S)-2-Octanol

Conditions
ConditionsYield
bei der Verseifung; succinic acid di--ester;
(S)-2-Octanol
6169-06-8

(S)-2-Octanol

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride
39637-99-5, 20445-33-4

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

(R)-2-octyl (R)-α-methoxy-α-trifluoromethylphenylacetate
20445-10-7

(R)-2-octyl (R)-α-methoxy-α-trifluoromethylphenylacetate

Conditions
ConditionsYield
With dmap In dichloromethane at 0 - 20℃;100%
(S)-2-Octanol
6169-06-8

(S)-2-Octanol

acetic anhydride
108-24-7

acetic anhydride

(S)-1-methylheptyl acetate
3540-05-4

(S)-1-methylheptyl acetate

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 20℃; for 13h;99%
With pyridine93.1%
for 1h; Heating;82%
With dmap at 30℃; for 18h;
With dmap
(S)-2-Octanol
6169-06-8

(S)-2-Octanol

(R)-(-)-2-iodooctane
29117-48-4

(R)-(-)-2-iodooctane

Conditions
ConditionsYield
With 1H-imidazole; iodine; triphenylphosphine In dichloromethane for 1h; Ambient temperature;98%
With iodine In Petroleum ether for 6h; Heating;25%
With hydrogen iodide
(S)-2-Octanol
6169-06-8

(S)-2-Octanol

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

(S)-2-<(Methanesulfonyl)oxy>octane
62820-85-3

(S)-2-<(Methanesulfonyl)oxy>octane

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0℃;98%
With pyridine for 2h;86%
With triethylamine In dichloromethane at 15 - 20℃; for 1h;
With pyridine
With pyridine
(S)-2-Octanol
6169-06-8

(S)-2-Octanol

2,2,6-trimethyl-4H-1,3-dioxin-4-one
5394-63-8

2,2,6-trimethyl-4H-1,3-dioxin-4-one

(S)-2-octyl acetoacetate
143913-51-3

(S)-2-octyl acetoacetate

Conditions
ConditionsYield
for 0.1h; microwave irradiation;98%
(S)-2-Octanol
6169-06-8

(S)-2-Octanol

Acetylenedicarboxylic acid
142-45-0

Acetylenedicarboxylic acid

bis[(1S)-1-methylheptyl] acetylenedicarboxylate
1181217-27-5

bis[(1S)-1-methylheptyl] acetylenedicarboxylate

Conditions
ConditionsYield
With sulfuric acid In tetrahydrofuran for 14h; Reflux;97%
(S)-2-Octanol
6169-06-8

(S)-2-Octanol

benzoic acid
65-85-0

benzoic acid

(S)-benzoic acid 1-methylheptyl ester
6938-51-8, 78687-05-5, 98819-31-9, 34881-29-3

(S)-benzoic acid 1-methylheptyl ester

Conditions
ConditionsYield
With cyanomethylenetributyl-phosphorane In benzene at 100℃; for 24h;96%
(S)-2-Octanol
6169-06-8

(S)-2-Octanol

4-nitro-benzoic acid
62-23-7

4-nitro-benzoic acid

(1R)-1-methylheptyl 4-nitrobenzoate

(1R)-1-methylheptyl 4-nitrobenzoate

Conditions
ConditionsYield
With azodicarboxylic acid bis(2-methoxyethyl) ester; triphenylphosphine In toluene at 20℃; Product distribution / selectivity; Mitsunobu reaction;96%
With azodicarboxylic acid bis(2-methoxyethyl) ester; triphenylphosphine In toluene at 20℃; for 3.5h; Mitsunobu reaction; Inert atmosphere; stereospecific reaction;96%
With ethyl 2-(3,4-dichlorophenyl)azocarboxylate; triphenylphosphine In toluene at 20℃; for 5h; Mitsunobu Displacement; Inert atmosphere;93%
(S)-2-Octanol
6169-06-8

(S)-2-Octanol

4,4'-Dihydroxybenzophenone
611-99-4

4,4'-Dihydroxybenzophenone

4,4’-bis[(R)-2-octyloxy]benzophenone

4,4’-bis[(R)-2-octyloxy]benzophenone

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran; toluene at 0 - 20℃; for 17.5h; Inert atmosphere;96%
(S)-2-Octanol
6169-06-8

(S)-2-Octanol

(R)-2-chlorooctane
18651-57-5

(R)-2-chlorooctane

Conditions
ConditionsYield
With 1-chloro-1-(dimethylamino)-2-methyl-1-propene In dichloromethane 1.) 0 deg C; 2.) rt., 3h;95%
With trichloroacetonitrile; triphenylphosphine In acetonitrile for 1h; Ambient temperature;70%
With diethyl ether; phosphorus trichloride
(S)-2-Octanol
6169-06-8

(S)-2-Octanol

methyl 5-chloro-2-fluoro-4-hydroxy-benzoate
245743-64-0

methyl 5-chloro-2-fluoro-4-hydroxy-benzoate

(R)-5-chloro-2-fluoro-4-(2-octyloxy)benzoate
211172-74-6

(R)-5-chloro-2-fluoro-4-(2-octyloxy)benzoate

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In dichloromethane at 25℃; for 2h; Etherification;95%
(S)-2-Octanol
6169-06-8

(S)-2-Octanol

ethyl acetoacetate
141-97-9

ethyl acetoacetate

(S)-2-octyl acetoacetate
143913-51-3

(S)-2-octyl acetoacetate

Conditions
ConditionsYield
for 0.333333h; microwave irradiation;95%
(S)-2-Octanol
6169-06-8

(S)-2-Octanol

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

(S)-1-methylheptyl tosylate
34817-25-9

(S)-1-methylheptyl tosylate

Conditions
ConditionsYield
With trimethylamine hydrochloride; triethylamine In dichloromethane at 0℃; for 1h; Inert atmosphere;94%
With trimethylamine hydrochloride; triethylamine In dichloromethane at 0℃; for 2h; Inert atmosphere;94%
With pyridine at 4℃; Inert atmosphere;92%
(S)-2-Octanol
6169-06-8

(S)-2-Octanol

4-(methoxycarbonyloxy)benzoic acid
14180-11-1

4-(methoxycarbonyloxy)benzoic acid

4-methoxycarbonyloxybenzoic acid (S)-1-methylheptyl ester
271786-19-7

4-methoxycarbonyloxybenzoic acid (S)-1-methylheptyl ester

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; for 48h;94%
(S)-2-Octanol
6169-06-8

(S)-2-Octanol

methyl 4-hydroxylbenzoate
99-76-3

methyl 4-hydroxylbenzoate

methyl 4-{[(1R)-1-methylheptyl]oxy} benzoate
138705-74-5

methyl 4-{[(1R)-1-methylheptyl]oxy} benzoate

Conditions
ConditionsYield
Stage #1: (S)-2-Octanol; methyl 4-hydroxylbenzoate With triphenylphosphine In tetrahydrofuran at 0℃; for 0.25h; Mitsunobu reaction;
Stage #2: With di-isopropyl azodicarboxylate In tetrahydrofuran at 0 - 20℃; for 8h; Mitsunobu reaction;		94%
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran
(S)-2-Octanol
6169-06-8

(S)-2-Octanol

benzoic acid
65-85-0

benzoic acid

(R)-benzoic acid 1-methylheptyl ester
6938-51-8, 34881-29-3, 98819-31-9, 78687-05-5

(R)-benzoic acid 1-methylheptyl ester

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran; toluene at 20℃; Product distribution / selectivity; Mitsunobu reaction;93%
With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine In benzene at 60℃; for 24h;91%
With azodicarboxylic acid bis(2-methoxyethyl) ester; triphenylphosphine In diethyl ether at 20℃; for 2h; Mitsunobu reaction; Inert atmosphere; stereospecific reaction;89%
(S)-2-Octanol
6169-06-8

(S)-2-Octanol

N,N-diethyl 4'-bromo-4-methoxybiphenyl-2-carboxamide
666829-99-8

N,N-diethyl 4'-bromo-4-methoxybiphenyl-2-carboxamide

(R)-N,N-diethyl 4'-bromo-4-(1-methylheptyloxy)biphenyl-2-carboxamide
666830-01-9

(R)-N,N-diethyl 4'-bromo-4-(1-methylheptyloxy)biphenyl-2-carboxamide

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In dichloromethane at 25℃; for 4h; Mitsunobu reaction;93%
(S)-2-Octanol
6169-06-8

(S)-2-Octanol

4-{(S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-3-oxo-butyric acid ethyl ester

4-{(S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-3-oxo-butyric acid ethyl ester

4-{(S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-3-oxo-butyric acid (S)-1-methyl-heptyl ester

4-{(S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-3-oxo-butyric acid (S)-1-methyl-heptyl ester

Conditions
ConditionsYield
In chlorobenzene for 0.5h; microwave irradiation;92%
(S)-2-Octanol
6169-06-8

(S)-2-Octanol

2-Iodobenzoyl chloride
609-67-6

2-Iodobenzoyl chloride

C15H21IO2
1093198-58-3

C15H21IO2

Conditions
ConditionsYield
92%
(S)-2-Octanol
6169-06-8

(S)-2-Octanol

4-Bromobenzoic acid
586-76-5

4-Bromobenzoic acid

(S)-1-methylheptyl 4-bromobenzoate
1160843-08-2

(S)-1-methylheptyl 4-bromobenzoate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃;92%
4-nitro-phenol
100-02-7

4-nitro-phenol

(S)-2-Octanol
6169-06-8

(S)-2-Octanol

(S)-4-(1-methylheptyl)oxy-1-nitrobenzene
850903-50-3

(S)-4-(1-methylheptyl)oxy-1-nitrobenzene

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 10 - 20℃; Inert atmosphere;91%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 18h; Mitsunobu Displacement;91%
With di-isopropyl azodicarboxylate; triphenylphosphine In diethyl ether at 0 - 20℃;90%
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran
(S)-2-Octanol
6169-06-8

(S)-2-Octanol

benzaldehyde
100-52-7

benzaldehyde

({[(1S)-1-methylheptyl]oxy}methyl)benzene

({[(1S)-1-methylheptyl]oxy}methyl)benzene

Conditions
ConditionsYield
With triethylsilane; ytterbium(III) triflate In 1,2-dichloro-ethane for 4h; Reflux;91%
With triethylsilane; iron(III) chloride In nitromethane at 20℃; for 1h;81%
Carbonyl fluoride
353-50-4

Carbonyl fluoride

(S)-2-Octanol
6169-06-8

(S)-2-Octanol

C9H17FO2

C9H17FO2

Conditions
ConditionsYield
With potassium fluoride In diethyl ether at 0℃;90%

D(+)-2-Octanol Chemical Properties

IUPAC Name: (2S)-octan-2-ol
The MF of (S)-(+)-2-Octanol(6169-06-8): C8H18O
The MW of (S)-(+)-2-Octanol(6169-06-8): 130.23
EINECS: 228-213-6
bp: 175 °C(lit.)
alpha: 9.5 °(neat)
density: 0.822 g/mL at 25 °C(lit.)
refractive index: n20/D 1.426(lit.)
Fp: 160 °F
Water Solubility: 1 g/L (20 °C)
Vapour Pressure: 0.306 mmHg at 25°C 
Appearance: Colorless to light yellow liquid
Stability: Stable. Combustible. Incompatible with strong oxidizing agents
Categories: Alcohols, Hydroxy Esters and Derivatives;Chiral Compounds;chiral;Building Blocks for Liquid Crystals;Chiral Building Blocks;Chiral Compounds (Building Blocks for Liquid Crystals);Functional Materials;Simple Alcohols (Chiral);Synthetic Organic Chemistry;Chiral Compound;AlcoholsDerivatization Reagents;Chiral GC Derivatization Reagents;Chiral Building Blocks;Chiral Derivatization;ChiralDerivatization Reagents;Derivatization Reagents HPLC;Organic Building Blocks
Synonyms: D(+)-2-OCTANOL;D-2-OCTANOL;(s)-2-octano;(S)-octan-2-ol;(S)-(+)-2-HYDROXYOCTANE;(S)-2-HYDROXYOCTANE;(S)-(+)-2-OCTANOL;(S)-2-OCTANOL
The Structure of (S)-(+)-2-Octanol(6169-06-8):

D(+)-2-Octanol Safety Profile

Hazard Codes: Xi
Risk Statements: 36/37/38
36/37/38:  Irritating to eyes, respiratory system and skin 
Safety Statements: 26-36-37/39
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 
36:  Wear suitable protective clothing 
37/39:  Wear suitable gloves and eye/face protection 
WGK Germany: 3
HS Code: 29051620

D(+)-2-Octanol Specification

1. First Aid Measures
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
Remove from exposure to fresh air immediately. Get medical aid if cough or other symptoms appear.
Skin:
Get medical aid if irritation develops or persists. Flush skin with plenty of soap and water.
Eyes:
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
2. Handling and Storage
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling:
Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.

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