Conditions | Yield |
---|---|
With chlorotris(sodium 3-sulfonatophenyldiphenylphosphine)rhodium(I); hydrogen; sodium formate In water at 50℃; under 75007.5 Torr; for 20h; Inert atmosphere; | 100% |
With sodium hydrogencarbonate In water for 18h; Reagent/catalyst; Electrochemical reaction; | 93.6% |
Stage #1: carbon dioxide With phenylsilane In N,N-dimethyl acetamide at 50℃; under 22502.3 Torr; for 4h; pH=Ca. 1.2; Autoclave; Green chemistry; Stage #2: With water In N,N-dimethyl acetamide at 100℃; for 0.25h; Pressure; Temperature; Reagent/catalyst; Time; Green chemistry; | 91% |
Conditions | Yield |
---|---|
Stage #1: methanol With oxygen; nickel dichloride In water at 20℃; for 0.166667h; Flow reactor; Stage #2: With copper(II) sulfate In water at 55℃; for 0.166667h; Flow reactor; | 98% |
With sodium hydroxide; potassium hexacyanoferrate(III); iridium(III) chloride at 35℃; Rate constant; Thermodynamic data; ΔE, ΔS(excit.), ΔF(excit.); | |
With dipotassium peroxodisulfate In water at 45℃; Kinetics; Rate constant; Thermodynamic data; mechanism, concentration, temperature, overall energy of activation; |
Conditions | Yield |
---|---|
With iron(III) trifluoromethanesulfonate; 2-((4R,5R)-1-((4-(tert-butyl)phenyl)sulfonyl)-4,5-diphenylimidazolidin-2-yl)-6-((4R,5R)-1-((4-(tert-butyl)phenyl)sulfonyl)-4,5-diphenylimidazolidin-2-yl)pyridine; oxygen at 70℃; under 760.051 Torr; for 6h; Solvent; Green chemistry; | A n/a B 96% |
A
formic acid
B
3-(tert-butyldiphenylsilanyloxy)-2-methylpropionic acid
Conditions | Yield |
---|---|
With camphor-10-sulfonic acid; dihydrogen peroxide In chloroform-d1 | A 50% B 96% |
formic acid 2-formyloxy-1-methylpropyl ester
A
formic acid
B
trans-2-Butene
C
buta-1,3-diene
D
butanone
Conditions | Yield |
---|---|
at 500℃; for 5h; Mechanism; Inert atmosphere; Flow reactor; Pyrolysis; chemoselective reaction; | A 20% B n/a C 94% D n/a |
styrene
A
formaldehyd
B
formic acid
C
benzaldehyde
D
benzoic acid
Conditions | Yield |
---|---|
With pyridine; ozone at 20℃; for 1.16667h; Oxidation; ozonolysis; | A 2% B 2.4% C 2.6% D 93% |
Conditions | Yield |
---|---|
at 160℃; under 99.76 Torr; | A 92% B n/a |
Conditions | Yield |
---|---|
In perchloric acid; water Kinetics; react. at 30 +/- 0.2°C; detection by spectrophotometry; | A 90% B n/a C >99 D n/a |
Conditions | Yield |
---|---|
In perchloric acid; water Kinetics; react. at 30 +/- 0.2°C; detection by spectrophotometry; | A 90% B n/a C >99 D n/a |
formic acid
Conditions | Yield |
---|---|
With water at 20℃; for 0.5h; | 90% |
Conditions | Yield |
---|---|
Stage #1: syringic aldehyde With sodium percarbonate In tetrahydrofuran; water at 25℃; Dakin Phenol Oxidation; Inert atmosphere; Stage #2: With hydrogenchloride In tetrahydrofuran; water pH=1; Inert atmosphere; | A n/a B 90% |
6-methyl-6-phenyl-3-(1-phenylethyl)-5-(m-toluidino)-1,2,4-trioxan
A
formic acid
B
2-Phenylpropanal
C
acetophenone
D
1-amino-3-methylbenzene
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol for 0.0833333h; Ambient temperature; Further byproducts given; | A 58% B 69% C 89% D 75% |
Conditions | Yield |
---|---|
In water at 20℃; for 0.333333h; Schlenk technique; Inert atmosphere; Glovebox; | A 88% B n/a |
Conditions | Yield |
---|---|
Stage #1: sodium hydrogencarbonate With hydrogen In water at 200℃; under 45004.5 Torr; for 4h; Autoclave; Stage #2: Pressure; Reagent/catalyst; | 86.1% |
With nickel; hydrazine hydrate In water at 300℃; for 2h; Reagent/catalyst; Green chemistry; | 50% |
With sodium chloride at 40℃; for 2h; Irradiation; Halobacterium halobium MMT22; Yield given; |
Conditions | Yield |
---|---|
With potassium bromate; ruthenium trichloride; perchloric acid at 39.85℃; Kinetics; Further Variations:; Reagents; Temperatures; Oxidation; | 86% |
With phosphovanadomolybdic acid; oxygen In water at 150℃; under 15001.5 Torr; for 3h; | 73.9% |
With aluminium(III) triflate; dihydrogen peroxide In acetonitrile at 70℃; for 12h; | 63.1% |
Conditions | Yield |
---|---|
With dihydrogen peroxide In neat (no solvent) at 25℃; for 24h; Catalytic behavior; Reagent/catalyst; | A n/a B 86% |
With oxygen; vanadia In water at 79.84℃; under 2250.23 Torr; for 1h; Autoclave; | A 14 %Chromat. B 13 %Chromat. |
Conditions | Yield |
---|---|
With 2,6-dimethylpyridine; water at 120℃; under 9000.9 Torr; | 85% |
With sulfuric acid Hydrolysis; | |
With water; N-cyclohexyl-cyclohexanamine at 130℃; Equilibrium constant; Reagent/catalyst; |
Glyoxal
formic acid
Conditions | Yield |
---|---|
With phosphovanadomolybdic acid; oxygen In water at 150℃; under 15001.5 Torr; for 3h; | 84.3% |
With dihydrogen peroxide; sodium molybdate; mercury(II) diacetate In 1,4-dioxane; water at 25℃; for 0.5h; Yield given; | |
With TiClO4 at 39.9℃; Rate constant; Kinetics; Thermodynamic data; E(excit.), ΔH(excit.), ΔS(excit.); var. temp.; | |
With sodium vanadate; sulfuric acid; oxygen In water at 160℃; under 22502.3 Torr; for 0.0166667h; Autoclave; | |
With H(1+)*Mo11O40PV(4-)*3C7H13N2O3S(1+); oxygen In water at 180℃; under 7500.75 Torr; for 1h; Autoclave; | 74.2 %Chromat. |
Conditions | Yield |
---|---|
With hydrogen In water at 200℃; under 45004.5 Torr; for 4h; Autoclave; | 83.7% |
With [{Ir(pentamethylcyclopentadienyl)(Cl)}2(4,4',6,6'-tetrahydroxybipyrimidine)](Cl2); hydrogen In water at 50℃; under 30003 Torr; for 8h; Catalytic behavior; Reagent/catalyst; Pressure; Time; Temperature; | |
With hydrogen carbonate reductase; hydrogen under 750.075 Torr; Kinetics; Reagent/catalyst; Enzymatic reaction; |
Conditions | Yield |
---|---|
With dihydrogen peroxide In neat (no solvent) at 25℃; for 24h; Catalytic behavior; Reagent/catalyst; | A n/a B 86% |
With oxygen; vanadia In water at 79.84℃; under 2250.23 Torr; for 1h; Autoclave; | A 14 %Chromat. B 13 %Chromat. |
With iron hydroxide oxide; manganese(IV) oxide; dihydrogen peroxide In water at 25℃; for 24h; Reagent/catalyst; Autoclave; |
Conditions | Yield |
---|---|
With hydrogenchloride; water at 199.84℃; for 0.166667h; Concentration; Temperature; Time; | A 83% B 43% |
With water at 185 - 205℃; for 0.420833h; Product distribution / selectivity; Acidic conditions; | A 82% B n/a |
With 5-methyl-dihydro-furan-2-one at 159.84℃; for 16h; | A 20% B 69% |
Conditions | Yield |
---|---|
With perchloric acid; bromamine T In water at 35 - 40℃; Kinetics; Mechanism; Thermodynamic data; ΔH and ΔS; var. solv.: D2O; | A 82% B 82% |
With perchloric acid; mercury(II) diacetate; N-bromoacetamide In water at 30℃; Kinetics; Mechanism; effect of the concentrations of NBA, MIK, acid and Hg(OAc)2; effect of the ionic strength; D2O isotopic effect; further temperatures; |
Conditions | Yield |
---|---|
With phosphoric acid immobilized anatase TiO2 In tetrahydrofuran; water at 119.84℃; for 2h; Sealed tube; Green chemistry; | A 81.2% B 10.5% |
With dihydrogen peroxide In water at 200℃; for 1h; pH=5.4; | A 11.55% B 5.68% |
alpha-D-glucopyranose
A
5-hydroxymethyl-2-furfuraldehyde
B
formic acid
C
levulinic acid
D
levoglucosan
Conditions | Yield |
---|---|
With 15 wtpercent phosphate impregnated titania In water; butan-1-ol at 175℃; under 22502.3 Torr; for 3h; Catalytic behavior; Temperature; Inert atmosphere; Autoclave; | A 81% B n/a C n/a D n/a |
Glycolaldehyde
A
formic acid
B
glycolic Acid
C
Glyoxal
D
carbon dioxide
E
acetic acid
Conditions | Yield |
---|---|
With water; oxygen at 90℃; under 7500.75 Torr; for 8h; Catalytic behavior; Mechanism; Temperature; Pressure; Time; Reagent/catalyst; | A 80.5% B 4.2% C 6.2% D 2.6% E 0.3% |
D-Arabinose
formic acid
Conditions | Yield |
---|---|
With dihydrogen peroxide In ethanol; water at 69.84℃; for 5h; Inert atmosphere; Schlenk technique; chemoselective reaction; | 79.7% |
Conditions | Yield |
---|---|
With dihydrogen peroxide In ethanol; water at 69.84℃; for 5h; Inert atmosphere; Schlenk technique; chemoselective reaction; | 79.6% |
With phosphovanadomolybdic acid; oxygen In water at 180℃; under 15001.5 Torr; for 3h; | 33.1% |
With sodium chloride In water at 189.84℃; under 15001.5 Torr; for 2h; Reagent/catalyst; Temperature; Sealed tube; Inert atmosphere; | 9.6% |
With sodium vanadate; sulfuric acid; oxygen In water at 160℃; under 22502.3 Torr; for 0.0166667h; Autoclave; | |
With C13H16ClN3O2Pd; dihydrogen peroxide; sodium hydroxide In water at 25℃; for 16h; Catalytic behavior; |
Conditions | Yield |
---|---|
With sulfuric acid | 79% |
With water Electrolysis.Mehrkammersystem mit Kammerwaenden aus semipermeablen Ionenaustauschern; | |
With sulfuric acid; sulfur trioxide |
Conditions | Yield |
---|---|
With tert.-butylhydroperoxide; bis(acetylacetonato)dioxidomolybdenum(VI) In benzene at 70℃; for 48h; Product distribution; other reaction times, other catalysts, other allylic alcohols and olefins as substrates; | A n/a B 79% C 6% |
3β-formyloxy-5αH-cholestane
A
formic acid
B
cholestane
C
Cholestanol
Conditions | Yield |
---|---|
In N,N,N,N,N,N-hexamethylphosphoric triamide; water for 5h; Irradiation; | A n/a B 79% C 19% |
Conditions | Yield |
---|---|
With iodopentafluorobenzene bis(trifluoroacetate); water In benzene Product distribution; Heating; other alkynes or α-hydroxy-p-nitroacetophenone; | A n/a B 79% |
Conditions | Yield |
---|---|
With cyano-hydroxyimino-acetic acid 2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water at 20℃; for 3h; Reagent/catalyst; Solvent; | 100% |
With aminoproplylated mesoporous SBA-15 silica at 40℃; for 0.25h; Neat (no solvent); chemoselective reaction; | 95% |
With NH2-MIL-53 at 50℃; for 0.333333h; | 95% |
Conditions | Yield |
---|---|
With cyano-hydroxyimino-acetic acid 2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In water at 20℃; for 3h; Reagent/catalyst; Solvent; | 100% |
In butan-1-ol at 120℃; Solvent; Temperature; | 99.35% |
In ethanol at 140℃; for 24h; Solvent; Autoclave; | 98% |
Conditions | Yield |
---|---|
With sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ethyl cyanoglyoxylate-2-oxime In water; N,N-dimethyl-formamide at 20℃; for 3h; Reagent/catalyst; Solvent; | 100% |
Conditions | Yield |
---|---|
toluene-4-sulfonic acid at 85℃; for 4h; Esterification; | 100% |
With 2-methyl-1-butylimidazolium trifluoroacetate In neat (no solvent) at 70℃; for 1h; | 96% |
Stage #1: formic acid With acetic anhydride at 40℃; for 2h; Stage #2: 1-dodecyl alcohol at 0 - 20℃; for 15.25h; | 94% |
With hydrogenchloride |
Conditions | Yield |
---|---|
In water for 19h; | 100% |
at 20 - 25℃; for 4h; | 100% |
for 5h; Reflux; | 89.3% |
for 5h; Reflux; |
Conditions | Yield |
---|---|
In water at 100℃; for 3h; Phillips cyclization; | 100% |
In water at 100℃; for 3h; | 84.1% |
Conditions | Yield |
---|---|
With acetic anhydride at 20℃; for 1h; | 100% |
With acetic anhydride at 20℃; for 19h; | 87% |
In N,N-dimethyl-formamide for 0.166667h; Heating; | 81% |
Conditions | Yield |
---|---|
With water In aq. phosphate buffer at 20℃; for 1h; pH=7.4; Catalytic behavior; Reagent/catalyst; Electrolysis; Inert atmosphere; Enzymatic reaction; | 100% |
With cobalt(III) acetylacetonate; hydrogen; bis(trifluoromethanesulfonyl)amide; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine] In tetrahydrofuran; ethanol at 100℃; under 52505.3 Torr; for 24h; Autoclave; Inert atmosphere; | 59% |
With C36H54IrN2P2(1+)*C24H20B(1-); hydrogen; sodium hydride In ethanol; toluene at 180℃; under 7500.75 - 45004.5 Torr; for 18h; Autoclave; | 31% |
Conditions | Yield |
---|---|
at 60℃; for 1h; Inert atmosphere; | 100% |
at 0 - 60℃; for 3.5h; | 78% |
at 50℃; Fraktionierung im Vakuum; |
Conditions | Yield |
---|---|
In toluene Reflux; | 100% |
With sodium formate at 20℃; for 2h; Neat (no solvent); | 98% |
With TiO2-SO4(2-) In acetonitrile at 20℃; for 6h; | 98.3% |
Conditions | Yield |
---|---|
In toluene Reflux; | 100% |
With sodium formate at 20℃; for 3h; Neat (no solvent); | 99% |
With TiO2-SO4(2-) In acetonitrile at 20℃; for 4h; | 99% |
formic acid
2-(3,4-dimethoxyphenyl)-ethylamine
N-[2-(3,4-dimethoxyphenyl)ethyl]formamide
Conditions | Yield |
---|---|
With acetic anhydride 1.) 60 deg C, 30 min, 2.) 20 deg C, overnight; | 100% |
With 4-methyl-morpholine; dmap; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In dichloromethane at 35℃; for 0.05h; microwave irradiation; | 98% |
In dichloromethane at 80℃; for 8h; | 95% |
Conditions | Yield |
---|---|
Stage #1: formic acid With acetic acid at 25℃; for 1h; Stage #2: phenethylamine at 0 - 25℃; | 100% |
With sulfated tungstate at 70℃; for 0.166667h; Neat (no solvent); | 98% |
With pyridine; diisopropyl-carbodiimide at 20℃; for 72h; | 15% |
Conditions | Yield |
---|---|
With hydrogenchloride In water for 3h; Reflux; | 100% |
at 110℃; for 4h; | 95% |
With tetrabutyl-ammonium chloride In water; toluene at 160℃; for 0.25h; Microwave irradiation; | 89% |
Conditions | Yield |
---|---|
With sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ethyl cyanoglyoxylate-2-oxime In water; N,N-dimethyl-formamide at 20℃; for 3h; Reagent/catalyst; Solvent; | 100% |
With zinc(II) oxide at 70℃; for 0.166667h; | 99% |
Stage #1: formic acid With silica gel at 20℃; for 0.0166667h; Stage #2: aniline With silica gel at 110℃; for 0.05h; | 99% |
Conditions | Yield |
---|---|
With hydrogenchloride In water for 8h; Reflux; | 100% |
With tetrabutyl-ammonium chloride In water; toluene at 160℃; for 0.2h; Microwave irradiation; | 90% |
With chloro-trimethyl-silane In water; N,N-dimethyl-formamide at 120℃; for 0.2h; Microwave irradiation; | 90% |
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 110℃; for 0.666667h; | 100% |
In N,N-dimethyl-formamide at 153℃; for 0.333333h; futher solvents, further temperatures, further reaction times; | 97% |
Stage #1: formic acid With acetic anhydride at 45℃; for 1h; Inert atmosphere; Stage #2: glycine at 20℃; for 72h; Inert atmosphere; | 93% |
Conditions | Yield |
---|---|
In toluene Reflux; | 100% |
In toluene Reflux; | 100% |
In toluene Reflux; | 100% |
Conditions | Yield |
---|---|
Stage #1: formic acid With silica gel at 20℃; for 0.0166667h; Stage #2: 4-Methoxybenzyl alcohol With silica gel at 110℃; for 0.0166667h; | 100% |
With aminopropylated mesoporous SBA-15 silica at 40℃; for 0.0833333h; Neat (no solvent); chemoselective reaction; | 95% |
With iodine at 20℃; for 0.116667h; neat (no solvent); | 94% |
Conditions | Yield |
---|---|
With sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ethyl cyanoglyoxylate-2-oxime In water; N,N-dimethyl-formamide at 20℃; for 3h; Reagent/catalyst; Solvent; | 100% |
With 4-methyl-morpholine; dmap; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine In dichloromethane at 35℃; for 0.1h; microwave irradiation; | 99% |
With sulfated tungstate at 70℃; for 0.166667h; Neat (no solvent); | 99% |
Conditions | Yield |
---|---|
In toluene Reflux; | 100% |
With sodium formate at 20℃; for 2.75h; Neat (no solvent); | 99% |
With zinc(II) oxide at 70℃; for 0.333333h; | 98% |
Conditions | Yield |
---|---|
at 100℃; | 100% |
With hydrogenchloride In water for 3h; Reflux; | 97.5% |
for 2h; Reflux; | 85% |
With hydrogenchloride | |
Stage #1: formic acid; 4-Bromo-benzene-1,2-diamine for 2h; Reflux; Stage #2: With sodium hydroxide In water at 20℃; |
formic acid
methyl α-chloro-α-phenylbenzeneacetate
methyl (formyloxy)diphenylacetate
Conditions | Yield |
---|---|
With sodium formate for 4h; Ambient temperature; | 100% |
With sodium formate In N,N-dimethyl-formamide for 3h; Ambient temperature; | 96% |
Conditions | Yield |
---|---|
Stage #1: formic acid With acetic anhydride In dichloromethane at 20℃; for 0.166667h; Stage #2: 2-iodophenylamine In dichloromethane at 20℃; | 100% |
In water; toluene at 110℃; for 4h; | 99% |
Stage #1: formic acid With acetic anhydride at 20℃; for 0.166667h; Inert atmosphere; Stage #2: 2-iodophenylamine In dichloromethane at 20℃; for 2h; Inert atmosphere; | 98% |
formic acid
tetra(n-butyl)ammonium hydroxide
tetra(n-butyl)ammonium formate
Conditions | Yield |
---|---|
In water pH=Ca. 8.45; Glovebox; | 100% |
In methanol; water at 20 - 60℃; | 99% |
In methanol at 20℃; for 2h; Inert atmosphere; | 85% |
formic acid
4-(2-aminoethyl)-1-(phenylmethyl)piperidine
1-benzyl-4-<2-(N-formylamino)ethyl>piperidine
Conditions | Yield |
---|---|
With acetic anhydride | 100% |
at 100℃; for 6h; | 38% |
formic acid
1-(4-hydroxy-phenyl)-piperazine dihydrobromide
1-Formyl-4-(4-hydroxyphenyl)piperazine
Conditions | Yield |
---|---|
With sodium carbonate In water; toluene for 18h; Heating; | 100% |
formic acid
1-(2,2-dimethyl-3-but-enyl)-5-hydroxy-2-pyrrolid-one
rel-(6R,7aS)-6-<2-(formyloxy)prop-2-yl>hexahydro-3H-pyrrolizin-3-one
Conditions | Yield |
---|---|
for 0.0833333h; Ambient temperature; | 100% |
at 40℃; for 0.0833333h; | 0.462 g |
Conditions | Yield |
---|---|
for 2h; Ambient temperature; | 100% |
Some alchemists and naturalists were aware that ant hills gave off an acidic vapor as early as the 15th century. The English naturalist,John Ray was the first person to describe the isolation of this substance (by the distillation of large numbers of ants) in 1671. Ants secrete the formic acid for attack and defense purposes.
The French chemist Joseph Gay-Lussac, first synthesized formic acid from hydrocyanic acid . In 1855, another French chemist, Marcellin Berthelot, developed a synthesis from carbon monoxide that is similar to that used today. In the late 1960s, significant quantities of it became available as a byproduct of acetic acid production.
Reported in EPA TSCA Inventory.
OSHA PEL: TWA 5 ppm
ACGIH TLV: 5 ppm; STEL 10 ppm
DFG MAK: 5 ppm (9.5 mg/m3)
DOT Classification: 8; Label: Corrosive
For occupational chemical analysis use OSHA: #ID-112 or NIOSH: Formic Acid S173.
Formic acid (CAS NO.64-18-6) is a flammable colorless fuming liquid with a strong irritating smell, it is soluble in water, ethanol and ether, slightly soluble in benzene. Burning will produce nitrogen oxides emitted toxic fumes. Besides should be stored and transported in low-temperature, drying environment. Separately with bases, oxidizing agents, H hair pore-forming agent, cyanide, sand, water mist, carbon dioxide would be used if emergency.
Physical properties about Formic acid are: (1)ACD/LogP: -0.54; (2)ACD/LogD (pH 5.5): -2.30; (3)ACD/LogD (pH 7.4): -3.94; (4)ACD/BCF (pH 5.5): 1.00; (5)ACD/BCF (pH 7.4): 1.00; (6)ACD/KOC (pH 5.5): 1.00; (7)ACD/KOC (pH 7.4): 1.00; (8)#H bond acceptors: 2 ; (9)#H bond donors: 1; (10)Index of Refraction:1.342; (11)Molar Refractivity: 8.404 cm3; (12)Molar Volume: 39.867 cm3; (13)Polarizability: 3.331 10-24cm3; (14)Surface Tension: 35.8489990234375 dyne/cm; (15)Density: 1.155 g/cm3; (16)Flash Point: 29.888 °C; (17)Enthalpy of Vaporization: 22.69 kJ/mol; (18)Boiling Point: 100.56 °C at 760 mmHg; (19)Vapour Pressure: 36.4770011901855 mmHg at 25°C
Preparation of Formic acid: Formic acid is often produced as a byproduct in the manufacture of other chemicals, especially acetic acid. But This production is insufficient to meet the present demand for formic acid. In the laboratory, formic acid can be obtained by heating oxalic acid in anhydrous glycerol and extraction by steam distillation. Another preparation (it must be performed under a fume hood) is the acid hydrolysis of ethyl isonitrile using HCl solution:
C2H5NC + 2H2O → C2H5NH2 + HCOOH
Uses of Formic acid: The main use of formic acid is as a preservative and antibacterial agent in livestock feed. Formic acid also can be used in other fields:
1.To process organic latex (sap) into raw rubber.
2.Used in the textile industry and for the tanning of leather.
3.Beekeepers use formic acid as a miticide against the Tracheal (Acarapis woodi) mite and the Varroa mite.
4.Some formate esters are artificial flavorings or perfumes.
5.It is used in laboratories as a solvent modifier for HPLC separations of proteins and peptides, especially when the sample is being prepared for mass spectrometry analysis.
6.In 2006 researchers of EPFL, Switzerland, reported the use of formic acid as a hydrogen storage material.
7.Formic acid is often used as a source of hydride ion in synthetic organic chemistry.
8.In the laboratory, formic acid is also used as source for carbon monoxide.
When you are using this chemical, please be cautious about it as the following:
Wear suitable protective clothing and gloves;
In case of accident or if you feel unwell, seek medical advice immediately (show label where possible);
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;
Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer);
Wear suitable protective clothing, gloves and eye/face protection;
You can still convert the following datas into molecular structure:
(1)InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3);
(2)InChIKey=BDAGIHXWWSANSR-UHFFFAOYSA-N;
(3)SmilesC(O)=O;
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | oral | 4gm/kg (4000mg/kg) | AMA Archives of Industrial Health. Vol. 20, Pg. 517, 1959. | |
dog | LDLo | intravenous | 3gm/kg (3000mg/kg) | "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 146, 1955. | |
man | TCLo | inhalation | 7300ug/m3/8H (7.3mg/m3) | KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION | Archives of Toxicology. Vol. 66, Pg. 522, 1992. |
mouse | LC50 | inhalation | 6200mg/m3/15M (6200mg/m3) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 23(12), Pg. 49, 1979. |
mouse | LD50 | intraperitoneal | 940mg/kg (940mg/kg) | Igiena. Vol. 11, Pg. 507, 1962. | |
mouse | LD50 | intravenous | 145mg/kg (145mg/kg) | Zeitschrift fuer Ernaehrungswissenschaft. Vol. 9, Pg. 332, 1969. | |
mouse | LD50 | oral | 700mg/kg (700mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 23(12), Pg. 49, 1979. |
rabbit | LDLo | intravenous | 239mg/kg (239mg/kg) | "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 146, 1955. | |
rat | LC50 | inhalation | 15gm/m3/15M (15000mg/m3) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 23(12), Pg. 49, 1979. |
rat | LD50 | oral | 1100mg/kg (1100mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 23(12), Pg. 49, 1979. |
women | LDLo | oral | 2440ug/kg (2.44mg/kg) | American Journal of Emergency Medicine. Vol. 7, Pg. 286, 1989. | |
women | LDLo | oral | 2440ug/kg (2.44mg/kg) | BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA VASCULAR: SHOCK | American Journal of Emergency Medicine. Vol. 7, Pg. 286, 1989. |
women | TDLo | oral | 2200mg/kg (2200mg/kg) | Journal of Toxicology, Clinical Toxicology. Vol. 32, Pg. 199, 1994. | |
women | TDLo | oral | 2200mg/kg (2200mg/kg) | KIDNEY, URETER, AND BLADDER: HEMATURIA LUNGS, THORAX, OR RESPIRATION: SPUTUM | Journal of Toxicology, Clinical Toxicology. Vol. 32, Pg. 199, 1994. |
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