Guanidine supplier | CasNO.113-00-8

Name
Aminomethanamidine
EINECS
CAS No. 113-00-8
Article Data131
CAS DataBase
Density 1.55g/cm³
Solubility
Melting Point
Formula CH5 N3
Boiling Point 132.9°Cat760mmHg
Molecular Weight 59.0708
Flash Point 34.2°C
Transport Information
Appearance
Safety Poison by intraperitoneal and subcutaneous routes. Moderately toxic by ingestion. On heating to 160° it converts to melamine and NH₃. Keep well closed. When heated to decomposition it emits toxic fumes of NO_x.
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Aminoformamidine;Aminomethanamidine; Carbamamidine; Carbamidine; Guanidin; Imidourea; Iminourea
PSA 75.89000
LogP 0.33890

Synthetic route

: 110-68-9
N-n-butyl-N-methylamine

: 113-00-8
guanidine nitrate

Conditions

Conditions	Yield
With diisopropyl-carbodiimide	100%
With dicyclohexyl-carbodiimide	99.7%

: 109-73-9
N-butylamine

: 113-00-8
guanidine nitrate

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide	99%
With diisopropyl-carbodiimide	96.7%

: 62-53-3
aniline

: 693-13-0
diisopropyl-carbodiimide

: 113-00-8
guanidine nitrate

Conditions

Conditions	Yield
With C36H44N12Sn4 at 60℃; for 0.5h; Temperature; Time; Inert atmosphere; Schlenk technique;	98.9%

: 127099-85-8, 780722-26-1
dicyandiamide

: ammonium chloride

: 113-00-8
guanidine nitrate

Conditions

Conditions	Yield
180-200°C; 30 min;	88%

: ammonium bromide

: 127099-85-8, 780722-26-1
dicyandiamide

: 113-00-8
guanidine nitrate

Conditions

Conditions	Yield
180-200°C; 30 min;	87%

: ammonium iodide

: 127099-85-8, 780722-26-1
dicyandiamide

: 113-00-8
guanidine nitrate

Conditions

Conditions	Yield
180-200°C; 30 min;	83%

: 10581-07-4
N-cyclohexyl-N',N'-pentamethylenediylurea

: 13360-63-9
N-ethylbutylamine

: 113-00-8
guanidine nitrate

Conditions

Conditions	Yield
With trichlorophosphate In water; toluene	81%

: 7664-41-7
ammonia

: 57-13-6
urea

: 113-00-8
guanidine nitrate

Conditions

Conditions	Yield
With sulfur dioxide at molar ratio of urea:SO2:NH3 = 1:3:7; 245-265°C; in autoclave;	80%
With aluminum(III) sulfate; ammonium chloride In ammonia High Pressure; 300°C; 30 min; urea : NH4Cl : Al2(SO4)3 = 1:1:0.33; 140 atm;	72%
With aluminum(III) sulfate; ammonium chloride In ammonia High Pressure; 300°C; 30 min; urea : NH4Cl : Al2(SO4)3 = 1:1:0.33; 70 atm;	68%

: 420-04-2
CYANAMID

: 1484-26-0
3-(benzyloxy)aniline

A: 113-00-8
guanidine nitrate

B: 205935-12-2
N-(3-Benzyloxy-phenyl)-guanidine

Conditions

Conditions	Yield
In water	A n/a B 80%

...Expand

: 124-46-9, 20734-13-8, 100224-74-6, 593-85-1
guanidine hydrogen carbonate

: 113-00-8
guanidine nitrate

Conditions

Conditions	Yield
With ammonia; potassium at 50℃; for 72h; Autoclave;	78%

: ammonium sulfate

: 127099-85-8, 780722-26-1
dicyandiamide

: 113-00-8
guanidine nitrate

Conditions

Conditions	Yield
With small amt. of H2O 160-180°C;	77%

: 420-04-2
CYANAMID

aniline ester: aniline ester

: 113-00-8
guanidine nitrate

Conditions

Conditions	Yield
With conc. HNO3 In ethanol	76.5%

: ammonium phosphate

: 420-04-2
CYANAMID

: 113-00-8
guanidine nitrate

Conditions

Conditions	Yield
In water Kinetics; byproducts: urea, NH3; at molar ratio of H2NCN:NH4(1+):PO4(3-) = 1:2:1; 1 h; 140°C;	70%

: 509-14-8
tetranitromethane

: 113-00-8
guanidine nitrate

Conditions

Conditions	Yield
With hydrogenchloride; sulfur dioxide; iron In water dropwise addn. of 2 N HCl or aq. SO2 to a mixture consisting of H2O, Fe-turnings and C(NO2)4;	50%

: 127099-85-8, 780722-26-1
dicyandiamide

: 113-00-8
guanidine nitrate

Conditions

Conditions	Yield
With sulfuric acid In water byproducts: NH3, formaldehyde; Electrolysis; Pb-cathode, 1 A/dm2, (>2.5 h);	49%
With H2SO4 In water byproducts: NH3, formaldehyde; Electrolysis; Pb-cathode, 1 A/dm2, (>2.5 h);	49%
With sulfuric acid In water byproducts: NH3, formaldehyde; Electrolysis; Hg-cathode, 1 A/dm2, (>2.5 h);	31%

: 127099-85-8, 780722-26-1
N-Cyanoguanidine

A: 4405-08-7
2,4-diamino-6-guanidino-1,3,5-triazine

B: 141-83-3
carbamimidoylurea

C: 32151-75-0
2,4,6-triguanidino-1,3,5-triazine

D: 113-00-8
guanidine nitrate

Conditions

Conditions	Yield
With hydrogenchloride In N,N-dimethyl-formamide at 80℃; for 0.5h;	A 8% B n/a C 42% D n/a
With hydrogenchloride In N,N-dimethyl-formamide at 80℃; for 1.83333h; Yield given;	A 8% B n/a C 42% D n/a

...Expand

: 563-70-2
bromonitromethane

: 113-00-8
guanidine nitrate

Conditions

Conditions	Yield
With iron In water dropwise addn. of 2 N HCl or aq. SO2 to a mixture consisting of H2O, Fe-chips and BrC(NO2)3; very vigorous react.; cooling;	30%
With Fe; HCl or aq. SO2 In water

: 56-23-5
tetrachloromethane

: 113-00-8
guanidine nitrate

Conditions

Conditions	Yield
With ammonia; iodine; copper at 140℃; unter hohem Druck;

: 506-78-5
cyanogen iodide

: 113-00-8
guanidine nitrate

Conditions

Conditions	Yield
With ethanol; ammonia at 100℃;

: 108-19-0
BIURET

: 113-00-8
guanidine nitrate

Conditions

Conditions	Yield
With hydrogenchloride at 160 - 170℃;

: 420-04-2
CYANAMID

A: 645-93-2
ammelide

B: 113-00-8
guanidine nitrate

C: 127099-85-8, 780722-26-1
N-Cyanoguanidine

D: 57-13-6
urea

Conditions

Conditions	Yield
at 180℃; bei 185grad entsteht auch Ammoniumcarbonat;

...Expand

: 420-04-2
CYANAMID

: 113-00-8
guanidine nitrate

Conditions

Conditions	Yield
With ethanol; ammonium chloride at 100℃;
With water at 180℃;
With water at 155℃; in Gegenwart eines Ammoniumsalzes im Rohr;

: 420-04-2
CYANAMID

A: 113-00-8
guanidine nitrate

B: 127099-85-8, 780722-26-1
N-Cyanoguanidine

Conditions

Conditions	Yield
With ammonia; water

: 78-09-1
orthocarbonic acid tetraethyl ester

: 113-00-8
guanidine nitrate

Conditions

Conditions	Yield
With ammonia; water at 150℃;

: 76-06-2
chloropicrin

: 113-00-8
guanidine nitrate

Conditions

Conditions	Yield
With ethanol; ammonia at 100℃; unter Druck;

: 1943-16-4
chlorotrinitromethane

: 113-00-8
guanidine nitrate

Conditions

Conditions	Yield
With hydrogenchloride; iron
With hydrogenchloride; nickel coated zinc

: 106200-44-6
2-amino-3-cyano-5-p-carbomethoxyphenethylpyridine

: 113-00-8
guanidine nitrate

: 106200-45-7
4-amino-4-deoxy-5,10-dideazapteroic acid

Conditions

Conditions	Yield
In 2-methoxy-ethanol at 100℃; for 72h;	100%

: 28123-73-1
5-(4-nitrophenyl)-furan-2-carboxylic acid

: 113-00-8
guanidine nitrate

: [5-(4-nitrophenyl)furan-2-ylcarbonyl]guanidine

Conditions

Conditions	Yield
Stage #1: 5-(4-nitrophenyl)-furan-2-carboxylic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 20℃; for 0.5h; Stage #2: guanidine nitrate In tetrahydrofuran; methanol at 20℃; for 12h;	99%

: 113-00-8
guanidine nitrate

: 959-33-1
3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one

: 59807-19-1
4-(4-methoxyphenyl)-6-phenylpyrimidin-2-ylamine

Conditions

Conditions	Yield
With titanium(IV) oxide In ethanol for 0.333333h; Time; UV-irradiation;	99%
With sodium carbonate In acetonitrile at 80℃;	55%

: 2,2'-bis-bromomethyl-3,3'-bis-(3',5'-di-tert-butyl-biphenyl-4-yl)-[1,1']binaphthalenyl

: 113-00-8
guanidine nitrate

: 2,6-bis-(3',5'-di-tert-butyl-biphenyl-4-yl)-3,5-dihydro-4-aza-cyclohepta[2,1-a;3,4-a']dinaphthalene-4-carboxamidine

Conditions

Conditions	Yield
In tetrahydrofuran; ethanol at 20℃; for 12h;	98%

: 10,10-dioxo-10,11-dihydro-5-oxa-10λ6-thia-dibenzo[a,d]cycloheptene-8-carboxylic acid

: 113-00-8
guanidine nitrate

: N-(10,10-dioxo-10,11-dihydro-5-oxa-10λ6-thia-dibenzo[a,d]cycloheptene-8-carbonyl)-guanidine

Conditions

Conditions	Yield
Stage #1: 10,10-dioxo-10,11-dihydro-5-oxa-10λ6-thia-dibenzo[a,d]cycloheptene-8-carboxylic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide for 1h; Stage #2: guanidine nitrate In methanol; N,N-dimethyl-formamide for 1h;	98%

: C23H28N2O4

: 113-00-8
guanidine nitrate

: 1318802-85-5
C22H24N4O3

Conditions

Conditions	Yield
With sodium ethanolate	98%

: 28762-10-9
Bis<2,2-dinitroethyl>-nitramine

: 113-00-8
guanidine nitrate

: bis(guanidinium) bis(2,2-dinitroethanide)nitroamine salt

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 1h;	98%

: 16619-28-6
1-phenyl-3-o-methylphenyl-2-propen-1-one

: 113-00-8
guanidine nitrate

: 98-86-2
acetophenone

: 57162-60-4
4-(2'-methylphenyl)-2,6-diphenylpyridine

Conditions

Conditions	Yield
for 0.0666667h; Microwave irradiation; neat (no solvent);	98%

...Expand

: 6552-68-7
4-chloro-4'-methoxy-chalcone

: 113-00-8
guanidine nitrate

: 100-06-1
1-(4-methoxyphenyl)ethanone

: 2,6-bis(4-methoxyphenyl)-4-(4-chlorophenyl)pyridine

Conditions

Conditions	Yield
for 0.0666667h; Microwave irradiation; neat (no solvent);	98%

...Expand

: 113-00-8
guanidine nitrate

: 94-41-7
benzalacetophenone

: 98-86-2
acetophenone

: 580-35-8
2,4,6-triphenylpyridine

Conditions

Conditions	Yield
for 0.0666667h; Microwave irradiation; neat (no solvent);	98%

...Expand

: C21H23NO

: 113-00-8
guanidine nitrate

: C20H19N3

Conditions

Conditions	Yield
With sodium In ethanol at 80℃; for 24h;	98%

: 113-00-8
guanidine nitrate

: 292638-85-8
acrylic acid methyl ester

: 15231-27-3
2-amino-1,4,5,6-tetrahydropyrimidin-4-one

Conditions

Conditions	Yield
In isopropyl alcohol at 25℃; for 4h;	97%

: 113-00-8
guanidine nitrate

: 167030-95-7
4-[2-(5-Cyano-6-methoxy-2-oxo-1,2,3,4-tetrahydro-pyridin-3-yl)-ethyl]-benzoic acid methyl ester

: 213256-78-1
methyl 4-[2-(2,4-diamino-7-oxo-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl)ethyl]benzoate

Conditions

Conditions	Yield
In methanol for 48h; Heating;	97%
In methanol Cycloaddition; Heating;
In methanol Heating;

: 113-00-8
guanidine nitrate

: 63699-97-8
1,2:5,6-dianhydro-3,4-O-methylethylidene-L-iditol

: 206655-86-9
(5S,6R,7R,8S)-5,6,7,8-tetrahydroxy-6,7-methylethylidene-2-imino-1,3-diazonane

Conditions

Conditions	Yield
In ethanol for 1h; Cycloaddition; Heating;	97%

: 113-00-8
guanidine nitrate

: 63700-05-0
1,2;5,6-dianhydro-3,4-O-isopropylidene-D-mannitol

: 206655-87-0
(5R,6R,7R,8R)-5,6,7,8-tetrahydroxy-6,7-O-methylethylidene-2-imino-1,3-diazonane

Conditions

Conditions	Yield
In ethanol for 1h; Cycloaddition; Heating;	97%

: 32953-38-1
ethyl 1-ethyl-6-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylate

: 113-00-8
guanidine nitrate

: N-(1-ethyl-6-methoxy-4-oxo-1,4-dihydro-quinoline-3-carbonyl)-guanidine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 20℃; guanylation;	97%

: 956-04-7
3-(4-chlorophenyl)-1-phenylprop-2-en-1-one

: 99-91-2
para-chloroacetophenone

: 113-00-8
guanidine nitrate

: 72673-14-4
2,4-Bis(4-chlorophenyl)-6-phenylpyridine

Conditions

Conditions	Yield
for 0.0666667h; Microwave irradiation; neat (no solvent);	97%

...Expand

: 113-00-8
guanidine nitrate

: 98-86-2
acetophenone

: 956-02-5
4'-chlorochalcone

: 74918-91-5
2,4-diphenyl-6-(4-chlorophenyl)pyridine

Conditions

Conditions	Yield
for 0.0666667h; Microwave irradiation; neat (no solvent);	97%

...Expand

: 113-00-8
guanidine nitrate

: 118364-47-9
(E)-2-(4-Chloro-phenyl)-3-methoxy-but-2-enenitrile

: 3275-44-3
2,4-diamino-5-(4-chlorophenyl)-6-methylpyrimidine

Conditions

Conditions	Yield
In dimethyl sulfoxide at 80℃; for 0.0833333h;	96%

: 113-00-8
guanidine nitrate

: 98-86-2
acetophenone

: 1030-27-9, 22965-98-6, 72758-79-3
4-dimethylamino-chalcone

: 29312-59-2
4-(2,6-diphenylpyridin-4-yl)-N,N-dimethylaniline

Conditions

Conditions	Yield
for 0.0666667h; Microwave irradiation; neat (no solvent);	96%

...Expand

: 113-00-8
guanidine nitrate

: 122-00-9
para-methylacetophenone

: 6552-66-5, 50990-40-4, 102692-51-3
3-(4-methoxyphenyl)-1-p-tolylprop-2-en-1-one

: 75573-10-3
2,6‐bis(4‐methylphenyl)‐4‐methoxyphenylpyridine

Conditions

Conditions	Yield
for 0.0666667h; Microwave irradiation; neat (no solvent);	96%

...Expand

: 94-02-0
ethyl 3-oxo-3-phenylpropionate

: 100-52-7
benzaldehyde

: 113-00-8
guanidine nitrate

: 2-amino-5-benzoyl-5,6-dihydro-6-phenyl pyrimidin-4(3H)-one

Conditions

Conditions	Yield
With sodium hydrogencarbonate at 120℃; for 0.2h; Microwave irradiation;	96%

...Expand

: C23H29N3O9

: 113-00-8
guanidine nitrate

: C22H28N6O8

Conditions

Conditions	Yield
at 20℃; for 0.166667h;	96%

: 39061-97-7
4-chloro-3-nitroquinoline

: 113-00-8
guanidine nitrate

: 51294-35-0
(3-nitro-quinolin-4-yl)-guanidine

Conditions

Conditions	Yield
With sodium ethanolate In ethanol	95%

: 113-00-8
guanidine nitrate

: 63699-97-8
1,2:5,6-dianhydro-3,4-O-methylethylidene-L-iditol

: (3aR,4S,10S,10aR)-2,2-Dimethyl-7-methylene-octahydro-1,3-dioxa-6,7λ5,8-triaza-cyclopentacyclononene-4,10-diol

Conditions

Conditions	Yield
In ethanol for 1h; Heating;	95%

: 113-00-8
guanidine nitrate

: 63700-05-0
1,2;5,6-dianhydro-3,4-O-isopropylidene-D-mannitol

: (3aR,4R,10R,10aR)-2,2-Dimethyl-7-methylene-octahydro-1,3-dioxa-6,7λ5,8-triaza-cyclopentacyclononene-4,10-diol

Conditions

Conditions	Yield
In ethanol for 1h; Heating;	95%

: 5-(2-isopropoxyphenyl)furan-2-carboxylic acid methyl ester

: 113-00-8
guanidine nitrate

: [5-(2-isopropoxyphenyl)furan-2-ylcarbonyl]guanidine

Conditions

Conditions	Yield
In methanol for 12h; Heating;	95%

Guanidine Chemical Properties

Structure of Guanidine (CAS NO.113-00-8):

Molecular Formula: CH₅N₃
Molar mass: 59.07 g/mol
EINECS: 204-021-8
Density: 1.55 g/cm³
Flash Point: 34.2 °C
Index of Refraction: 1.595
Boiling Point: 132.9 °C at 760 mmHg
Vapour Pressure: 8.67 mmHg at 25°C
Appearance: Colorless crystals
Solubility: Easily soluble in water and alcohol
Product categories: Pharmaceutical Intermediates
XLogP3-AA: -1.3
H-Bond Donor: 3
H-Bond Acceptor: 3
IUPAC Name: Guanidine
Canonical SMILES: C(=N)(N)N
InChI: InChI=1S/CH5N3/c2-1(3)4/h(H5,2,3,4)
InChIKey: ZRALSGWEFCBTJO-UHFFFAOYSA-N

Guanidine Uses

Guanidine (CAS NO.113-00-8) is used in the manufacture of plastics and explosives and as intermediate in organic synthesis. Is mainly used for manufacture of sulfa drugs and dyes. Because of free guanidine difficult to be separated, so general merchandise is its salts, such as Guanidine hydrochloride , Guanidine nitrate , Guanidine carbonate , Guanidine sulfate .

Guanidine Production

Guanidine (CAS NO.113-00-8) can be pbtained from the role of Calcium and Ammonium iodide or the reaction of Urea and Ammonia under pressurized.

Guanidine Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
frog	LDLo	subcutaneous	3gm/kg (3000mg/kg)	"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1352, 1935.
mouse	LD50	intraperitoneal	350mg/kg (350mg/kg)	Bulletin of Experimental Biology and Medicine Vol. 61, Pg. 291, 1966.
mouse	LDLo	subcutaneous	266mg/kg (266mg/kg)	"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1352, 1935.
rabbit	LDLo	oral	500mg/kg (500mg/kg)	"Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 718, 1989.
rat	LDLo	subcutaneous	150mg/kg (150mg/kg)	"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1352, 1935.

Guanidine Safety Profile

Poison by intraperitoneal and subcutaneous routes. Moderately toxic by ingestion. On heating to 160° it converts to melamine and NH₃. Keep well closed. When heated to decomposition it emits toxic fumes of NO_x.

Guanidine Specification

Guanidine (CAS NO.113-00-8) is a crystalline compound of strong alkalinity, and also can be called Carbamamidine ; Iminourea ; Guanidinium sulfate ; Bisguanidinium sulfate and Aminoformamidine . There is deliquescence, and it is easy to absorb carbon dioxide from the air tobe strongly alkaline. When heated to 160 °C, it will be decomposed into Melamine and Ammonia .

Product Name

Aminomethanamidine

Synthetic route

Guanidine Chemical Properties

Guanidine Uses

Guanidine Production

Guanidine Toxicity Data With Reference

Guanidine Safety Profile

Guanidine Specification

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