Guanidine carbonate supplier

Name
Guanidine carbonate
EINECS 209-813-7
CAS No. 593-85-1
Density 1.25
Solubility 450 g/L (20°C) in water
Melting Point >300 °C(lit.)
Formula C₃H₁₂N₆O₃
Boiling Point 132.9 °C at 760 mmHg
Molecular Weight 90.0833
Flash Point 34.2 °C
Transport Information
Appearance white to almost white crystalline powder
Safety 26-36-22
Risk Codes 36/37/38-20/21/22
Molecular Structure
Hazard Symbols Xn
Synonyms Diguanidinium carbonate;Carbonic acid, compd. with guanidine (1:2);Guanidinium carbonate;Bisguanidinium carbonate;Guanidincarbonat;Guanidine Carbonate (P077);
PSA 209.31000
LogP 0.90020

Synthetic route

: 113-00-8
guanidine nitrate

: 593-85-1
diguanidine carbonate

Conditions

Conditions	Yield
Darstellung;

: 28787-21-5
nitrocarbamoyl-guanidine

: 109-73-9
N-butylamine

A: 1792-17-2
N,N'-di-n-butylurea

B: 44987-80-6
N-butyl-N'-guanyl-urea

C: 593-85-1
diguanidine carbonate

...Expand

: 127099-85-8, 780722-26-1
N-Cyanoguanidine

: 593-85-1
diguanidine carbonate

Conditions

Conditions	Yield
With ammonia; water
With sodium carbonate at 160℃; unter Druck;

: 4245-76-5
N-methyl-N'-nitroguanidine

: 7732-18-5
water

(NH4)2CO3: (NH4)2CO3

: 593-85-1
diguanidine carbonate

Conditions

Conditions	Yield
at 65 - 70℃;

...Expand

: 5458-83-3
N-butyl-N'-nitro-guanidine

: 7732-18-5
water

(NH4)2CO3: (NH4)2CO3

A: 593-85-1
diguanidine carbonate

B: 462-69-1
N-butylguanidine

Conditions

Conditions	Yield
at 65 - 70℃;

...Expand

: 28787-21-5
nitrocarbamoyl-guanidine

: 62-53-3
aniline

A: 18824-43-6
N-carbamimidoyl-N'-phenyl-urea

B: 593-85-1
diguanidine carbonate

C: 102-07-8
bis(diphenyl)urea

D carbamoylguanidine carbonate: carbamoylguanidine carbonate

Conditions

Conditions	Yield
Produkt5:Cyanursaeure;

...Expand

: 556-88-7
nitroguanidine

ammonium carbonate: ammonium carbonate

: 593-85-1
diguanidine carbonate

Conditions

Conditions	Yield
Darstellung;

cyanogendiamidine carbonate: cyanogendiamidine carbonate

: 593-85-1
diguanidine carbonate

Conditions

Conditions	Yield
With carbon dioxide; water

: 1147550-11-5
ammonium thiocyanate

NH3: NH3

: 593-85-1
diguanidine carbonate

Conditions

Conditions	Yield
und folgendes Erhitzen mit 1 Mol Bleicarbonat auf 120grad in geschlossenen Gefaessen;
und folgendes Erhitzen mit 1 Mol Bleicarbonat auf 120grad in geschlossenen Gefaessen;

thiocyanic acid guanidine: thiocyanic acid guanidine

: 593-85-1
diguanidine carbonate

Conditions

Conditions	Yield
With ethanol; water; potassium carbonate

: 141-83-3
carbamimidoylurea

water: water

: 593-85-1
diguanidine carbonate

Conditions

Conditions	Yield
at 90 - 140℃;

cyanogendiamidine carbonate: cyanogendiamidine carbonate

water: water

: 593-85-1
diguanidine carbonate

Conditions

Conditions	Yield
at 100℃;

: 113-00-8
guanidine nitrate

A: 593-85-1
diguanidine carbonate

B: 57-13-6
urea

Conditions

Conditions	Yield
In not given Kinetics; byproducts: (NH4)2CO3, ammonium cyanate, guanidinium cyanate; heating with reflux; 3 h; 0.125 N soln. of guanidine;

: 127099-85-8, 780722-26-1
dicyandiamide

: 7664-41-7
ammonia

: 1066-33-7
ammonium bicarbonate

A: 108-78-1
2,4,6-triamino-s-triazine

B: 593-85-1
diguanidine carbonate

Conditions

Conditions	Yield
small amt. of melamine;

...Expand

: 141-83-3
carbamimidoylurea

: 593-85-1
diguanidine carbonate

Conditions

Conditions	Yield
In water byproducts: NH3, CO2; 2h at b.p., or 7-8 h at 90°C, or <30 min at 140°C (under pressure);	74-98.5

: 127099-85-8, 780722-26-1
dicyandiamide

: 497-19-8
sodium carbonate

: 593-85-1
diguanidine carbonate

Conditions

Conditions	Yield
In water heating in closed tube;

: 127099-85-8, 780722-26-1
dicyandiamide

: 593-85-1
diguanidine carbonate

Conditions

Conditions	Yield
With ammonia In water heating in closed tube;

: 893420-41-2
(E)-3-dimethylamino-1-(3-ethyl-2-trifluoromethyl-3H-imidazol-4-yl)-propenone

: 593-85-1
diguanidine carbonate

: 893420-42-3
4-(3-ethyl-2-trifluoromethyl-3H-imidazol-4-yl)-pyrimidin-2-ylamine

Conditions

Conditions	Yield
In 2-methoxyethoxy ether at 140℃; for 48h;	100%

: (E)-3-dimethylamino-1-(3-ethyl-2-trifluoromethyl-3H-imidazol-4-yl)-propenone

: 593-85-1
diguanidine carbonate

: 893420-42-3
4-(3-ethyl-2-trifluoromethyl-3H-imidazol-4-yl)-pyrimidin-2-ylamine

Conditions

Conditions	Yield
In diethylene glycol dimethyl ether at 140℃; for 48h;	100%

: 5018-30-4
dimethyl methoxymalonate

: 593-85-1
diguanidine carbonate

: 98142-98-4
2-amino-5-methoxypyrimidine-4,6-diol

Conditions

Conditions	Yield
Stage #1: diguanidine carbonate With ethanol; sodium at 80℃; for 0.5h; Inert atmosphere; Stage #2: dimethyl methoxymalonate at 80℃; for 2h;	100%

: 75-59-2
tetramethyl ammoniumhydroxide

: 593-85-1
diguanidine carbonate

: cis,cis-1,3,5-trimethylcyclohexane-1,3,5-tricarboxylic acid

: [(CH3)4N(+)]*2[C(NH2)3(+)]*[KTA(3-)]

Conditions

Conditions	Yield
In water at 40℃;	100%

...Expand

: 593-85-1
diguanidine carbonate

: 4499-86-9
tetrapropylammonium hydroxide

: cis,cis-1,3,5-trimethylcyclohexane-1,3,5-tricarboxylic acid

: [(nC3H7)4N(+)]*2[C(NH2)3(+)]*[KTA(3-)]

Conditions

Conditions	Yield
In water at 40℃;	100%

...Expand

: 593-85-1
diguanidine carbonate

: cis,cis-1,3,5-trimethylcyclohexane-1,3,5-tricarboxylic acid

: [C(NH2)3(+)]*[H2KTA(-)]

Conditions

Conditions	Yield
In water	100%

: 593-85-1
diguanidine carbonate

: cis,cis-1,3,5-trimethylcyclohexane-1,3,5-tricarboxylic acid

: 3[C(NH2)3(+)]*[KTA(3-)]

Conditions

Conditions	Yield
In water at 40℃;	100%

: cyclopentadienecarboxylic acid manganese tricarbonyl

: 593-85-1
diguanidine carbonate

: 1416228-87-9
C9H5MnO5*CH5N3

Conditions

Conditions	Yield
In methanol at 20℃; Darkness;	100%

: 33056-60-9
β-cymantrenoyl-propionic acid

: 593-85-1
diguanidine carbonate

: 1416228-98-2
C12H9MnO6*CH5N3

Conditions

Conditions	Yield
In methanol at 20℃; Darkness;	100%

: 875824-86-5
N-nitro-2,2,2-trinitroethylcarbamate

: 593-85-1
diguanidine carbonate

: N-nitro-2,2,2-trinitroethylcarbamate guanidinum salt

Conditions

Conditions	Yield
In ethyl acetate at 20℃; for 3h;	100%

: C14H16N8O16

: 593-85-1
diguanidine carbonate

: C14H16N8O16*4CH5N3

Conditions

Conditions	Yield
In water	100%

: 78-83-1
2-methyl-propan-1-ol

: 593-85-1
diguanidine carbonate

: N,N'-diisobutylguanidine

Conditions

Conditions	Yield
Stage #1: diguanidine carbonate With phosphoric acid; sulfuric acid Stage #2: 2-methyl-propan-1-ol at 80 - 100℃; for 24h;	99%

: 593-85-1
diguanidine carbonate

: 67-63-0
isopropyl alcohol

: 38588-65-7
N,N'-diisopropylguanidine

Conditions

Conditions	Yield
Stage #1: diguanidine carbonate With phosphoric acid; sulfuric acid Stage #2: isopropyl alcohol at 80 - 100℃; for 24h;	99%

: tetrapropylammonium hydroxide

: 11113-50-1
boric acid

: 593-85-1
diguanidine carbonate

: (C3H7)4N(1+)*C(NH2)3(1+)*CO3(2-)*2B(OH)3=((C3H7)4N)(C(NH2)3)CO3(B(OH)3)2

Conditions

Conditions	Yield
With CO2 In water mixt. guanidinium carbonate and n-Pr4NOH (1:1) was dissolved in water, CO2 was bubbled through soln. for 30 min, aq. B(OH)3 was slowly added, soln. was stirred for 15 min; soln. was filtered, crystals were deposited over several weeks;	99%

...Expand

: [3-fluoro-2-[2-(2-methoxypyrimidin-5-yl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-yl]-4-pyridyl]methanol

: 593-85-1
diguanidine carbonate

: 530-62-1
1,1'-carbonyldiimidazole

: [3-fluoro-2-[2-(2-methoxypyrimidin-5-yl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-yl]-4-pyridyl]methyl N-amidinocarbamate

Conditions

Conditions	Yield
Stage #1: [3-fluoro-2-[2-(2-methoxypyrimidin-5-yl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-5-yl]-4-pyridyl]methanol; 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere; Stage #2: diguanidine carbonate In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere;	99%

...Expand

: 593-85-1
diguanidine carbonate

: 133116-83-3
2-fluoro-6-(trifluoromethyl)benzonitrile

: 133116-84-4
5-(trifluoromethyl)quinazoline-2,4-diamine

Conditions

Conditions	Yield
With ISOPROPYLAMIDE at 128 - 130℃; for 5h;	98%

: 593-85-1
diguanidine carbonate

: 6-chloro-7-methyl-3-methylthio-1,4,2-benzodithiazin 1,1-dioxide

: 107639-37-2
N-(6-chloro-1,1-dioxo-7-methyl-1,4,2-benzodithiazin-3-yl)guanidine

Conditions

Conditions	Yield
In toluene Heating;	98%

: 593-85-1
diguanidine carbonate

: 104-88-1
4-chlorobenzaldehyde

: 109-77-3
malononitrile

: 99973-69-0
2,4-diamino-6-(4-chlorophenyl)-5-pyrimidinecarbonitrile

Conditions

Conditions	Yield
With ZnO nanoparticles In water at 20℃; for 0.25h;	98%
With CuO microspheres In water at 20℃; for 0.25h;	98%
With sodium hydroxide at 70℃; Neat (no solvent);	90%
With D-glucose; oxygen In water at 50℃; for 2h;	86%

...Expand

: (3E,5E)-3,5-bis(2-chlorobenzylidene)-1-methylpiperidin-4-one

: 593-85-1
diguanidine carbonate

: C21H20Cl2N4

Conditions

Conditions	Yield
With (Fe2O3)-MCM-41-nPrNH2 In neat (no solvent) at 120℃; for 0.5h;	98%

: (3E,5E)-1-methyl-3,5-bis(4-nitrobenzylidene)piperidin-4-one

: 593-85-1
diguanidine carbonate

: C21H20N6O4

Conditions

Conditions	Yield
With (Fe2O3)-MCM-41-nPrNH2 In neat (no solvent) at 120℃; for 0.333333h;	98%

: 593-85-1
diguanidine carbonate

: 104-87-0
4-methyl-benzaldehyde

: 105-56-6
ethyl 2-cyanoacetate

: 2-amino-4-hydroxy-6-(p-tolyl)pyrimidine-5-carbonitrile

Conditions

Conditions	Yield
Stage #1: 4-methyl-benzaldehyde; ethyl 2-cyanoacetate With NH2-SBA-15 mesoporous silica In ethanol for 0.166667h; Stage #2: diguanidine carbonate In ethanol for 1.3h; Reflux;	98%

...Expand

: 593-85-1
diguanidine carbonate

: 555-16-8
4-nitrobenzaldehdye

: 105-56-6
ethyl 2-cyanoacetate

: 2-amino-4-hydroxy-6-(4-nitrophenyl)pyrimidine-5-carbonitrile

Conditions

Conditions	Yield
Stage #1: 4-nitrobenzaldehdye; ethyl 2-cyanoacetate With NH2-SBA-15 mesoporous silica In ethanol for 0.166667h; Stage #2: diguanidine carbonate In ethanol for 1.3h; Reflux;	98%

...Expand

: 937250-32-3
methyl 3-(3-bromobenzyl)-3-methyl-2-oxocyclohexanecarboxylate

: 593-85-1
diguanidine carbonate

: 937250-31-2
2-amino-8-(3-bromobenzyl)-8-methyl-5,6,7,8-tetrahydroquinazolin-4(3H)-one

Conditions

Conditions	Yield
In ethanol for 18h; Heating / reflux;	97%

: 86119-84-8, 7664-38-2
phosphoric acid

: 593-85-1
diguanidine carbonate

: zinc(II) oxide

: 2CN3H6(1+)*4Zn(2+)*5H(1+)*5PO4(3-)=(CN3H6)2*Zn4H5(PO4)5

Conditions

Conditions	Yield
In water carbonate and H3PO4 mixing in PTFE bottle, ZnO addn., shaking, standing (room temp., 1 d), heating (100°C, 5 d); vac. filtration, washing (water); elem. anal.;	97%

...Expand

: erbium(III) nitrate pentahydrate

: 593-85-1
diguanidine carbonate

: 144-62-7
oxalic acid

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: Er(3+)*2CHO2(1-)*C2O4(2-)*CH5N3*H(1+)

Conditions

Conditions	Yield
With sodium carbonate In water at 100℃; for 72h;	97%

...Expand

: 593-85-1
diguanidine carbonate

: 83060-72-4
3-amino-5-phenylthiophene-2-carbonitrile

: 109879-88-1
2,4-diamino-6-phenylthieno<3,2-d>pyrimidine

Conditions

Conditions	Yield
for 0.0833333h; heating above 200 deg C;	96%

: 893420-46-7
(E)-1-(2-difluoromethyl-3-ethyl-3H-imidazol-4-yl)-3-dimethylamino-propenone

: 593-85-1
diguanidine carbonate

: 893420-47-8
4-(2-difluoromethyl-3-ethyl-3H-imidazol-4-yl)-pyrimidin-2-ylamine

Conditions

Conditions	Yield
In monoethylene glycol diethyl ether at 137℃; for 48h;	96%

: (E)-1-(2-difluoromethyl-3-ethyl-3H-imidazol-4-yl)-3-dimethylamino-propenone

: 593-85-1
diguanidine carbonate

: 893420-47-8
4-(2-difluoromethyl-3-ethyl-3H-imidazol-4-yl)-pyrimidin-2-ylamine

Conditions

Conditions	Yield
In monoethylene glycol diethyl ether at 137℃; for 48h;	96%

: 3612-20-2
1-phenylmethyl-4-piperidone

: 593-85-1
diguanidine carbonate

: 105-34-0
methyl 2-cyanoacetate

: 945302-66-9
2-amino-9-benzyl-5-cyano-1,3,9-triazaspiro[5,5]undeca-2-en-4-one

Conditions

Conditions	Yield
Stage #1: diguanidine carbonate In methanol for 0.25h; Heating; Stage #2: 1-phenylmethyl-4-piperidone; methyl 2-cyanoacetate In methanol for 0.833333h; Knoevenagel condensation; Heating; Further stages.;	96%

...Expand

: 39742-60-4
1-(2-phenylethyl)-4-piperidinone

: 593-85-1
diguanidine carbonate

: 105-56-6
ethyl 2-cyanoacetate

: 17503-90-1
2-amino-9-(2-phenylethyl)-5-cyano-1,3,9-triazaspiro[5,5]undeca-2-en-4-one

Conditions

Conditions	Yield
Stage #1: diguanidine carbonate In methanol for 0.25h; Heating; Stage #2: 1-(2-phenylethyl)-4-piperidinone; ethyl 2-cyanoacetate In methanol for 0.333333h; Knoevenagel condensation; Heating; Further stages.;	96%

...Expand

Guanidine carbonate Chemical Properties

IUPAC Name: Carbonic acid; guanidine
Synonyms of Guanidine carbonate (CAS NO.593-85-1): Bisguanidinium carbonate ; Diguanidinium carbonate ; Guanidine carbonate (2:1) ; Carbonic acid, compd. with guanidine (1:2)
CAS NO: 593-85-1
Molecular Formula: C₃H₁₂N₆O₃
Molecular Weight: 180.17
Molecular Structure:
EINECS: 209-813-7
H bond acceptors: 3
H bond donors: 5
Freely Rotating Bonds: 0
Polar Surface Area: 18.84 ?2
Flash Point: 34.2 °C
Enthalpy of Vaporization: 37.04 kJ/mol
Boiling Point: 132.9 °C at 760 mmHg
Vapour Pressure: 8.67 mmHg at 25°C
Melting point: 267-270°C (dec.)
Water solubility: 450 g/L (20°C)
Appearance: white to almost white crystalline powder
Product Categories of Guanidine carbonate (CAS NO.593-85-1): Pharmaceutical Intermediates;Guanidines;Nitrogen Compounds;Organic Building Blocks
SMILES: O=C(O)O.[N@H]=C(N)N.[N@H]=C(N)N Copy
InChI: InChI=1/2CH5N3.CH2O3/c3*2-1(3)4/h2*(H5,2,3,4);(H2,2,3,4) Copy
InChIKey: STIAPHVBRDNOAJ-UHFFFAOYAU
Std. InChI: InChI=1S/2CH5N3.CH2O3/c3*2-1(3)4/h2*(H5,2,3,4);(H2,2,3,4) Copy
Std. InChIKey: STIAPHVBRDNOAJ-UHFFFAOYSA-N

Guanidine carbonate Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	oral	350mg/kg (350mg/kg)	Cesko-Slovenska Farmacie. Vol. 1, Pg. 434, 1952.
mouse	LDLo	unreported	500mg/kg (500mg/kg)	Annals of Tropical Medicine and Parasitology. Vol. 32, Pg. 177, 1938.
rabbit	LDLo	subcutaneous	500mg/kg (500mg/kg)	"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1352, 1935.

Guanidine carbonate Consensus Reports

Reported in EPA TSCA Inventory.

Guanidine carbonate Safety Profile

Hazard Codes: Xn
The Risk Statements: 36/37/38-20/21/22
20/21/22: Harmful by inhalation, in contact with skin and if swallowed
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements: 26-36-22
22: Do not breathe dust
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
WGK Germany: 3
Poison by ingestion. Moderately toxic by subcutaneous route. When heated to decomposition it emits toxic vapors of NOx.

Guanidine carbonate Specification

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media: In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.
Storage: Store Guanidine carbonate (CAS NO.593-85-1) in a cool, dry place. Keep container closed when not in use.

Product Name

Guanidine carbonate

Synthetic route

Guanidine carbonate Chemical Properties

Guanidine carbonate Toxicity Data With Reference

Guanidine carbonate Consensus Reports

Guanidine carbonate Safety Profile

Guanidine carbonate Specification

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