Imidazolyl-4-ethanol supplier

Name
Imidazolyl-4-ethanol
EINECS
CAS No. 872-82-2
Article Data14
CAS DataBase
Density 1.228 g/cm³
Solubility
Melting Point 82 °C
Formula C₅H₈N₂ O
Boiling Point 359.8ºC at 760 mmHg
Molecular Weight 112.131
Flash Point 171.4ºC
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 1H-Imidazole-4-ethanol(9CI);Imidazole-4(or 5)-ethanol (6CI,7CI);Imidazole-4-ethanol (8CI);2-(1H-Imidazol-4-yl)ethanol;4-(2-Hydroxyethyl)imidazole;4-(b-Hydroxyethyl)imidazole;Histaminol;
PSA 48.91000
LogP -0.05550

Synthetic route

: 50-00-0
formaldehyd

: 140-86-3
1,4-dihydroxy-2-butanone

: 872-82-2
2-(1H-imidazol-4-yl)ethanol

Conditions

Conditions	Yield
With ammonium hydroxide; copper(II) sulfate
With ammonium hydroxide; copper(I) sulfate In water at 80℃; for 2h;	31.6 g

: 90773-75-4
4-(2-hydroxy-ethyl)-1,3-dihydro-imidazole-2-thione

: 872-82-2
2-(1H-imidazol-4-yl)ethanol

Conditions

Conditions	Yield
With nitric acid

: 55-36-7
histamine hydrochloride

: 872-82-2
2-(1H-imidazol-4-yl)ethanol

Conditions

Conditions	Yield
With ethanol; diamine oxidase from pea seedling; liver alcohol dehydrogenase; NAD; catalase at 37℃; for 48h; phosphate buffer (pH 7);	34 mg
With hydrogenchloride; sodium nitrite In water at 40℃; for 2h; Reagent/catalyst; Temperature;

4-<β-amino-ethyl>-1(3)H-imidazole hydrochloride: 4-<β-amino-ethyl>-1(3)H-imidazole hydrochloride

: 872-82-2
2-(1H-imidazol-4-yl)ethanol

Conditions

Conditions	Yield
With barium nitrite; water

: 50-00-0
formaldehyd

: 140-86-3
1,4-dihydroxy-2-butanone

: 7664-41-7
ammonia

: 7732-18-5
water

: 7758-99-8
copper(II) sulfate

: 872-82-2
2-(1H-imidazol-4-yl)ethanol

Conditions

Conditions	Yield
at 70 - 80℃;

...Expand

: 51718-80-0
methyl 2-(1H-imidazol-4-yl)acetate hydrochloride

: 872-82-2
2-(1H-imidazol-4-yl)ethanol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran for 3h; Heating / reflux;

: 30290-08-5
4-(2′-methoxyethyl)imidazole

: 872-82-2
2-(1H-imidazol-4-yl)ethanol

Conditions

Conditions	Yield
With hydrogen bromide for 1.5h; Reflux;	5.41 g

: 872-82-2
2-(1H-imidazol-4-yl)ethanol

: tert-butyl 2-chloro-4-iodobenzoate

: C11H10ClN3O3*(x)ClH

Conditions

Conditions	Yield
Stage #1: 2-(1H-imidazol-4-yl)ethanol; tert-butyl 2-chloro-4-iodobenzoate With potassium phosphate; copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane In dimethyl sulfoxide at 50℃; for 2h; Stage #2: With hydrogenchloride In 1,4-dioxane at 70℃; for 15h;	96%

: copper(II) nitrate trihydrate

: 872-82-2
2-(1H-imidazol-4-yl)ethanol

: C10H16CuN6O8

Conditions

Conditions	Yield
In methanol for 1h; Heating;	58.8%

: 5305-59-9
4-amino-6-chloropyrimidine

: 872-82-2
2-(1H-imidazol-4-yl)ethanol

: 2-(1-(6-aminopyrimidin-4-yl)-1H-imidazole-4-yl)ethan-1-ol

Conditions

Conditions	Yield
With caesium carbonate In N,N-dimethyl-formamide at 140℃; for 12h;	58%
With caesium carbonate In N,N-dimethyl-formamide at 140℃; for 12h;	58%

: copper(II) nitrate trihydrate

: 872-82-2
2-(1H-imidazol-4-yl)ethanol

: C5H10CuN4O8

Conditions

Conditions	Yield
In methanol; water for 1h; Heating;	55.4%

: 2637-34-5
pyridine-2-thione

: 872-82-2
2-(1H-imidazol-4-yl)ethanol

: 2-<<2-<4(5)-imidazolyl>ethyl>thio>pyridine hydrobromide hydrate

Conditions

Conditions	Yield
With hydrogen bromide for 24h; Heating;	48%

: 872-82-2
2-(1H-imidazol-4-yl)ethanol

: 76-83-5
trityl chloride

: 127607-62-9
1-triphenylmethyl-4-(2-hydroxyethyl)-1H-imidazole

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 20℃; for 12h;	40%

: 872-82-2
2-(1H-imidazol-4-yl)ethanol

: 221164-86-9
ethyl 7-fluoro-3-ethoxy-6-nitroquinoxaline-2-carboxylate

: 221167-10-8
ethyl 3-ethoxy-7-[4-(2-hydroxyethyl)imidazol-1-yl]-6-nitroquinoxaline-2-carboxylate

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl acetamide at 120℃; for 15h;	28%
With triethylamine In N,N-dimethyl acetamide at 120℃; for 15h;	28%
With triethylamine

: copper(II) nitrate trihydrate

: 872-82-2
2-(1H-imidazol-4-yl)ethanol

: C20H32CuN8O4(2+)*2NO3(1-)

Conditions

Conditions	Yield
In methanol for 1h; Heating;	26.8%

: 872-82-2
2-(1H-imidazol-4-yl)ethanol

: 103-71-9
phenyl isocyanate

: 74294-66-9
Phenyl-carbamic acid 2-(1H-imidazol-4-yl)-ethyl ester

Conditions

Conditions	Yield
With pyridine at 80℃; for 0.5h;	803 mg

: 872-82-2
2-(1H-imidazol-4-yl)ethanol

: 98-59-9
p-toluenesulfonyl chloride

: 74294-60-3
NO-bis-p-tolylsulphonylhistaminol

Conditions

Conditions	Yield
With pyridine at -23℃; for 2h;	336 mg

: 872-82-2
2-(1H-imidazol-4-yl)ethanol

: 7732-18-5
water

: 645-65-8
2-(1H-imidazol-4-yl)acetic acid

Conditions

Conditions	Yield
UV-Licht.Irradiation;

: 872-82-2
2-(1H-imidazol-4-yl)ethanol

: 7697-37-2
nitric acid

5 (resp. 4)-nitro-imidazole-carboxylic acid-(4 resp. 5): 5 (resp. 4)-nitro-imidazole-carboxylic acid-(4 resp. 5)

: 24424-99-5
di-tert-butyl dicarbonate

: 872-82-2
2-(1H-imidazol-4-yl)ethanol

: 211503-47-8
tert-butyl 4-(2-hydroxyethyl)imidazole-1-carboxylate

Conditions

Conditions	Yield
With TEA In methanol at 20℃;

: 872-82-2
2-(1H-imidazol-4-yl)ethanol

: 908015-61-2
4-(2-methanesulfonyloxy-ethyl)-imidazole-1-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: TEA / methanol / 20 °C 2: TEA / CH2Cl2 / 1 h / 20 °C View Scheme

: 872-82-2
2-(1H-imidazol-4-yl)ethanol

: 56-92-8
histamine dichloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 336 mg / pyridine / 2 h / -23 °C 2: 180 mg / lithium azide / dimethylformamide / 18 h / 21 °C 3: 90 mg / aq. hydrochloric acid, hydrogen / palladium-charcoal / ethanol / 8 h View Scheme

: 872-82-2
2-(1H-imidazol-4-yl)ethanol

: 74294-62-5
4-(2-Azido-ethyl)-1-(toluene-4-sulfonyl)-1H-imidazole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 336 mg / pyridine / 2 h / -23 °C 2: 180 mg / lithium azide / dimethylformamide / 18 h / 21 °C View Scheme

: 2637-34-5
2-Mercaptopyridine

: 872-82-2
2-(1H-imidazol-4-yl)ethanol

: 2-{[2-(1H-Imidazol-4-yl)ethyl]thio}pyridine

Conditions

Conditions	Yield
In aqueous HBr

: 872-82-2
2-(1H-imidazol-4-yl)ethanol

: 98-59-9
p-toluenesulfonyl chloride

: 930768-34-6
2-[1-(toluene-4-sulfonyl)-1H-imidazol-4-yl]-ethanol

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran; dichloromethane for 0.333333h;

: 872-82-2
2-(1H-imidazol-4-yl)ethanol

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1571145-65-7
4-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-1H-imidazole

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 2h;	1.6 g
With 1H-imidazole at 20℃; for 2h;	1.6 g

: 872-82-2
2-(1H-imidazol-4-yl)ethanol

: tert-butyl 2-chloro-4-iodobenzoate

: tert-butyl 2-chloro-4-(4-(2-hydroxyethyl)-1H-imidazol-1-yl)benzoate

Conditions

Conditions	Yield
With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; potassium phosphate; copper(l) iodide In dimethyl sulfoxide at 20 - 50℃; for 2h; Inert atmosphere;

: 872-82-2
2-(1H-imidazol-4-yl)ethanol

: 76-83-5
trityl chloride

: methyl 4-nitro-3-[2-(1-tritylimidazol-4-yl)ethoxy]benzoate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine / N,N-dimethyl-formamide / 12 h / 20 °C 2: sodium hydride / N,N-dimethyl-formamide / 4 h / 70 °C View Scheme

: 872-82-2
2-(1H-imidazol-4-yl)ethanol

: 1-(6-(4-(2-bromoethyl)-1H-imidazol-1-yl)pyrimidin-4-yl)-3-ethylthiourea

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 140 °C 2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h 2.2: 0.5 h / 20 °C 3.1: phosphorus tribromide / dichloromethane / 20 °C View Scheme

Imidazolyl-4-ethanol Specification

The 1H-Imidazole-5-ethanol, with its cas register number 872-82-2, has its IUPAC name of 2-(1H-imidazol-5-yl)ethanol. This chemical is a kind of white or alomost white solid, and this chemical belongs to the product category which is pharmacetical.

The physical properties of this chemical could be summarized as: (1)ACD/BCF (pH 5.5): 1; (2)ACD/BCF (pH 7.4): 1; (3)ACD/KOC (pH 5.5): 1; (4)ACD/KOC (pH 7.4): 5.696; (5)#H bond acceptors: 3; (6)#H bond donors: 2; (7)#Freely Rotating Bonds: 3; (8)Polar Surface Area: 48.91; (9)Index of Refraction: 1.568; (10)Molar Refractivity: 29.861 cm³; (11)Molar Volume: 91.303 cm³; (12)Polarizability: 11.838 ×10^-24 cm³; (13)Surface Tension: 60.23 dyne/cm; (14)Density: 1.228 g/cm³; (15)Flash Point: 171.38 °C; (16)Enthalpy of Vaporization: 63.879 kJ/mol; (17)Boiling Point: 359.766 °C at 760 mmHg.

Use of 1H-Imidazole-5-ethanol: 1H-Imidazole-5-ethanol could react with 1H-pyridine-2-thione to produce 2-[2-(1H-imidazol-4-yl)-ethylsulfanyl]-pyridine; dihydrobromide.

This reation could occur in the following condition: reagent: 47percent aq. HBr; reaction time: 24 hours; other condition: heating; field: 48%.

Additionally, you could convert the following datas information into the molecular structure:
(1)Canonical SMILES: C1=C(NC=N1)CCO
(2)InChI: InChI=1S/C5H8N2O/c8-2-1-5-3-6-4-7-5/h3-4,8H,1-2H2,(H,6,7)
(3)InChIKey: HEEACTTWORLLPM-UHFFFAOYSA-N

Product Name

Imidazolyl-4-ethanol

Synthetic route

Imidazolyl-4-ethanol Specification

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