Product Name

  • Name

    Sarcosine

  • EINECS 203-538-6
  • CAS No. 107-97-1
  • Article Data122
  • CAS DataBase
  • Density 1.093 g/cm3
  • Solubility 1480 g/L (20 °C) in water
  • Melting Point 208-212 °C (dec.)(lit.)
  • Formula C3H7NO2
  • Boiling Point 195.1 °C at 760 mmHg
  • Molecular Weight 89.0941
  • Flash Point 71.8 °C
  • Transport Information
  • Appearance white crystalline powder
  • Safety 24/25-36-26
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 107-97-1 (Sarcosine)
  • Hazard Symbols IrritantXi
  • Synonyms Sarcosine(8CI);(Methylamino)acetic acid;(Methylamino)ethanoic acid;2-(Methylamino)acetic acid;Acetic acid, (methylamino)-;Methylglycine;N-Methylaminoaceticacid;N-Methylglycine;Sarcosin;Sarcosinic acid;
  • PSA 49.33000
  • LogP -0.31870

Synthetic route

Conditions
ConditionsYield
With recombinant mouse glycine N-methyltransferase In aq. buffer at 30℃; for 0.333333h; pH=8; Reagent/catalyst; Enzymatic reaction;
sarcosine tert-butyl ester
5616-81-9

sarcosine tert-butyl ester

sarcosine
107-97-1

sarcosine

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 20℃; for 2h;
glycolonitrile
107-16-4

glycolonitrile

methylamine
74-89-5

methylamine

sarcosine
107-97-1

sarcosine

Conditions
ConditionsYield
With water das entstechende Nitril wird durch konz. Salzsaeure verseift;
With water; sodium hydroxide at 25℃; for 1h; Inert atmosphere;
Stage #1: glycolonitrile; methylamine at 20℃; for 1h; Inert atmosphere;
Stage #2: With water; sodium hydroxide
sarcosine ethyl ester hydrochloride
52605-49-9

sarcosine ethyl ester hydrochloride

sarcosine
107-97-1

sarcosine

Conditions
ConditionsYield
With bromine; triethylamine In dichloromethane; water; ethyl acetate
formaldehyd
50-00-0

formaldehyd

glycine
56-40-6

glycine

sarcosine
107-97-1

sarcosine

Conditions
ConditionsYield
With sodium dihydrogenphosphate; zinc at 30℃; for 0.116667h;90%
With hydrogenchloride; water
O2-(2,4-dinitrophenyl) 1-[N-(carboxymethyl)-N-methylamino]diazen-1-ium-1,2-diolate
1083159-08-3

O2-(2,4-dinitrophenyl) 1-[N-(carboxymethyl)-N-methylamino]diazen-1-ium-1,2-diolate

sarcosine
107-97-1

sarcosine

Conditions
ConditionsYield
With GLUTATHIONE; diethylenetriaminopentaacetic acid In dimethyl sulfoxide at 37℃; pH=7.4; aq. phosphate buffer; Inert atmosphere;
N-(phosphonemethyl)glycine
1071-83-6

N-(phosphonemethyl)glycine

sarcosine
107-97-1

sarcosine

Conditions
ConditionsYield
With Pseudomonas putida T5 glyphosate C-P lyase In aq. phosphate buffer at 30℃; pH=7; Kinetics; Enzymatic reaction;
luzopeptin C
76110-01-5

luzopeptin C

A

sarcosine
107-97-1

sarcosine

B

D-Serine
312-84-5

D-Serine

C

L-β-hydroxy-N-methylvaline
77421-34-2

L-β-hydroxy-N-methylvaline

D

glycine
56-40-6

glycine

Conditions
ConditionsYield
With hydrogenchloride at 100℃; for 18h; Further byproducts given;
luzopeptin C
76110-01-5

luzopeptin C

A

sarcosine
107-97-1

sarcosine

B

D-Serine
312-84-5

D-Serine

C

3-hydroxy-6-methoxyquinoline-2-carboxylic acid
77421-33-1

3-hydroxy-6-methoxyquinoline-2-carboxylic acid

D

glycine
56-40-6

glycine

Conditions
ConditionsYield
With hydrogenchloride at 100℃; for 18h; Further byproducts given;
hydrogen cyanide
74-90-8

hydrogen cyanide

carbon

carbon

A

sarcosine
107-97-1

sarcosine

B

glycine
56-40-6

glycine

C

rac-Ala-OH
302-72-7

rac-Ala-OH

D

3-amino propanoic acid
107-95-9

3-amino propanoic acid

Conditions
ConditionsYield
With ammonia; water at -196℃; Further byproducts given;A 0.24 mmol
B 3.0 mmol
C 0.18 mmol
D 0.17 mmol
creatinine
60-27-5

creatinine

sarcosine
107-97-1

sarcosine

Conditions
ConditionsYield
Bei langandauernder Faeulnis;
With barium dihydroxide at 100℃; im Rohr;
chloroacetic acid
79-11-8

chloroacetic acid

methylamine
74-89-5

methylamine

sarcosine
107-97-1

sarcosine

Conditions
ConditionsYield
With water at 40℃;
With water
N-methyl-N-phenylmethanesulfonyl-glycine
859960-32-0

N-methyl-N-phenylmethanesulfonyl-glycine

sarcosine
107-97-1

sarcosine

Conditions
ConditionsYield
With hydrogenchloride Hydrolysis.im geschlossenen Rohr;
2-Picolinic acid
98-98-6

2-Picolinic acid

sarcosine
107-97-1

sarcosine

methane
34557-54-5

methane

ammonia
7664-41-7

ammonia

water
7732-18-5

water

A

sarcosine
107-97-1

sarcosine

B

glycine
56-40-6

glycine

C

2-aminobutanoic acid
2835-81-6

2-aminobutanoic acid

Conditions
ConditionsYield
With hydrogen byproducts: dl-α-amino-butiric acid, dl-alanine, β-alanine; by electric spark discharge or electric discharge;
C10H22N2O
1056469-56-7

C10H22N2O

A

sarcosine
107-97-1

sarcosine

B

(R)-2-heptylamine
123-82-0, 6240-90-0, 7795-34-8, 44745-29-1

(R)-2-heptylamine

Conditions
ConditionsYield
With novozyme 435; water at 70℃; for 147h; pH=7; aq. phosphate buffer; Enzymatic reaction;
C11H16N2O

C11H16N2O

A

sarcosine
107-97-1

sarcosine

B

(R)-1-phenyl-ethyl-amine
3886-69-9

(R)-1-phenyl-ethyl-amine

Conditions
ConditionsYield
With novozyme 435; water at 70℃; for 120h; pH=7; aq. phosphate buffer; Enzymatic reaction;
(S)-3-Hydroxy-3-methyl-2-methylamino-butyric acid (R)-2-(carboxymethyl-methyl-carbamoyl)-2-[(3-hydroxy-6-methoxy-quinoline-2-carbonyl)-amino]-ethyl ester

(S)-3-Hydroxy-3-methyl-2-methylamino-butyric acid (R)-2-(carboxymethyl-methyl-carbamoyl)-2-[(3-hydroxy-6-methoxy-quinoline-2-carbonyl)-amino]-ethyl ester

A

sarcosine
107-97-1

sarcosine

B

L-β-hydroxy-N-methylvaline
77421-34-2

L-β-hydroxy-N-methylvaline

C

(R)-3-Hydroxy-2-[(3-hydroxy-6-methoxy-quinoline-2-carbonyl)-amino]-propionic acid
77431-62-0

(R)-3-Hydroxy-2-[(3-hydroxy-6-methoxy-quinoline-2-carbonyl)-amino]-propionic acid

Conditions
ConditionsYield
With water; hydroxide
methylamine
74-89-5

methylamine

C

C

A

sarcosine
107-97-1

sarcosine

B

N-methylalanine
600-21-5

N-methylalanine

C

aspartic Acid
617-45-8

aspartic Acid

Conditions
ConditionsYield
With ammonia Yield given. Further byproducts given. Yields of byproduct given;
sarcosine
107-97-1

sarcosine

Conditions
ConditionsYield
With sodium azide; sulfuric acid; SC(NH2)2 In water; acetic acid at 25℃; Rate constant; other solvent; other catalysts;
With perchloric acid; ammonium sulfamate; sodium thiocyanide at 50℃; Rate constant; piperidinium perchlorate, 18h; transnitrosating studies;
methylamine
74-89-5

methylamine

C

C

A

sarcosine
107-97-1

sarcosine

B

glycine
56-40-6

glycine

C

rac-Ala-OH
302-72-7

rac-Ala-OH

D

3-amino propanoic acid
107-95-9

3-amino propanoic acid

Conditions
ConditionsYield
With ammonia Yield given. Further byproducts given. Yields of byproduct given;
glycine
56-40-6

glycine

A

sarcosine
107-97-1

sarcosine

B

N-methylglycine methylester
5473-12-1

N-methylglycine methylester

C

glycylglycine
556-50-3

glycylglycine

D

iminodiacetic acid
142-73-4

iminodiacetic acid

Conditions
ConditionsYield
With 5%-palladium/activated carbon; hydrogen at 180℃; under 300.03 Torr; for 0.166667h;
2-(N-methylphenylsulfonamido)acetic acid
46376-16-3

2-(N-methylphenylsulfonamido)acetic acid

sarcosine
107-97-1

sarcosine

Conditions
ConditionsYield
With sulfuric acid at 125 - 130℃;
methoxycarbonylmethylamine
616-34-2

methoxycarbonylmethylamine

A

morpholine-2,5-dione
34037-21-3

morpholine-2,5-dione

B

sarcosine
107-97-1

sarcosine

C

N-methylglycine methylester
5473-12-1

N-methylglycine methylester

D

dimethyl iminodiacetate
6096-81-7

dimethyl iminodiacetate

E

glycine
56-40-6

glycine

Conditions
ConditionsYield
With 5%-palladium/activated carbon; hydrogen at 180℃; under 300.03 Torr; for 0.166667h;
C16H19N2O4P
79760-89-7

C16H19N2O4P

A

sarcosine
107-97-1

sarcosine

B

phosphoric acid monophenyl ester
701-64-4

phosphoric acid monophenyl ester

C

p-toluidine
106-49-0

p-toluidine

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane for 0.0833333h;
cordyheptapeptides B

cordyheptapeptides B

A

sarcosine
107-97-1

sarcosine

B

L-leucine
61-90-5

L-leucine

C

N-Methyl-L-phenylalanine
2566-30-5

N-Methyl-L-phenylalanine

D

L-proline
147-85-3

L-proline

Conditions
ConditionsYield
With hydrogenchloride at 110℃; for 15h; Further byproducts. Title compound not separated from byproducts.;
Conditions
ConditionsYield
With Canyon Diablo iron meteorites at 140℃; for 24h; Reagent/catalyst; Temperature;
3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
58-08-2

3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

sarcosine
107-97-1

sarcosine

Conditions
ConditionsYield
With barium dihydroxide; water
With barium dihydroxide
(methylamino)acetonitrile
5616-32-0

(methylamino)acetonitrile

sarcosine
107-97-1

sarcosine

Conditions
ConditionsYield
With barium dihydroxide; water
With barium dihydroxide
perthamide C

perthamide C

A

sarcosine
107-97-1

sarcosine

B

O-methyl-L-threonine
4144-02-9

O-methyl-L-threonine

C

o-hydroxyl-phenylalanine
7423-92-9

o-hydroxyl-phenylalanine

D

cis-4-methyl-(S)-proline
6734-41-4

cis-4-methyl-(S)-proline

Conditions
ConditionsYield
With hydrogenchloride; water at 130℃;
sarcosine
107-97-1

sarcosine

ethanol
64-17-5

ethanol

sarcosine ethyl ester hydrochloride
52605-49-9

sarcosine ethyl ester hydrochloride

Conditions
ConditionsYield
With thionyl chloride at 0 - 78℃;100%
With hydrogenchloride99%
With hydrogenchloride at 20℃; for 72h;95%
With hydrogenchloride
With acetyl chloride for 3h; Reflux;
sarcosine
107-97-1

sarcosine

benzyl chloroformate
501-53-1

benzyl chloroformate

N-(Benzyloxycarbonyl)sarcosine
39608-31-6

N-(Benzyloxycarbonyl)sarcosine

Conditions
ConditionsYield
With sodium carbonate In 1,4-dioxane; water at 20℃;100%
With sodium carbonate In 1,4-dioxane; water 1.) 0 deg C, 1.5 h, 2.) room temperature, 11 h;99%
With sodium hydroxide In water at 0 - 20℃; for 16h;94%
methanol
67-56-1

methanol

sarcosine
107-97-1

sarcosine

N-methylglycine methyl ester hydrochloride
13515-93-0

N-methylglycine methyl ester hydrochloride

Conditions
ConditionsYield
With thionyl chloride for 6.5h; Cooling; Reflux; Inert atmosphere;100%
With thionyl chloride at 55℃; for 2h;92%
With thionyl chloride 1.) ice-salt bath, 20 min, 2.) room temperature, 2 h, 3.) reflux, 2 h;90%
sarcosine
107-97-1

sarcosine

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

N-(tert-butoxycarbonyl)sarcosine
13734-36-6

N-(tert-butoxycarbonyl)sarcosine

Conditions
ConditionsYield
With triethylamine In water for 6h;100%
With triethylamine In water at 25℃; for 3h;97%
With sodium hydroxide In 1,4-dioxane95%
sarcosine
107-97-1

sarcosine

A

formaldehyd
50-00-0

formaldehyd

B

carbon dioxide
124-38-9

carbon dioxide

C

methylamine
74-89-5

methylamine

Conditions
ConditionsYield
With hydrogenchloride; sodium hydroxide; sodium perchlorate; chlorine at 24.9℃; Mechanism; Rate constant; Equilibrium constant; multistep reaction: 1.) water, 298 deg K, 2.) water, 298 deg K; reactions under var. conditions;A 100%
B n/a
C n/a
formaldehyd
50-00-0

formaldehyd

sarcosine
107-97-1

sarcosine

2-nitro-benzaldehyde
552-89-6

2-nitro-benzaldehyde

3-methyl-5-(2'-nitrophenyl)oxazolidine
365275-13-4

3-methyl-5-(2'-nitrophenyl)oxazolidine

Conditions
ConditionsYield
In toluene for 1h; Heating;100%
In benzene for 1h; Heating;95%
Conditions
ConditionsYield
In toluene C60, C20H10N4((C4H9)2C6H3)3(C6H4)2(C10H2N2O4)(CHO), N-methylglycine (toluene) heated under N2 in dark for 6 h; cooled to 25°C, evapd. to dryness (reduced pressure); chromy. sepd., dissolved (CH3Cl), added Zn(OAc)2 in CH3OH, heated for 30 min; washed twice (H2O), dried (anhydrous Na2SO4), solvent evapd., chromy., reprecipitated from benzene-methanol;100%
formaldehyd
50-00-0

formaldehyd

sarcosine
107-97-1

sarcosine

(Z)-4-(2-ethoxybenzylidene)-2-phenyloxazol-5(4H)-one

(Z)-4-(2-ethoxybenzylidene)-2-phenyloxazol-5(4H)-one

(5R*,9R*)-9-(2-ethoxyphenyl)-7-methyl-2-phenyl-3-oxa-1,7-diazaspiro[4.4]non-1-en-4-one

(5R*,9R*)-9-(2-ethoxyphenyl)-7-methyl-2-phenyl-3-oxa-1,7-diazaspiro[4.4]non-1-en-4-one

Conditions
ConditionsYield
In benzene for 5h; Reflux; Dean-Stark; diastereoselective reaction;100%
sarcosine
107-97-1

sarcosine

diethylstilbestrol
56-53-1

diethylstilbestrol

C18H20O2*C3H7NO2

C18H20O2*C3H7NO2

Conditions
ConditionsYield
In methanol at 20℃;99.01%
methanol
67-56-1

methanol

sarcosine
107-97-1

sarcosine

N-methylglycine methylester
5473-12-1

N-methylglycine methylester

Conditions
ConditionsYield
With thionyl chloride at 0℃; for 3.5h;99%
With thionyl chloride
(i) SOCl2, (ii) /BRN= 1098229/; Multistep reaction;
at 0 - 20℃; for 12h;
sarcosine
107-97-1

sarcosine

2-(Diethoxy-phosphoryl)-thioacetimidic acid methyl ester; hydriodide

2-(Diethoxy-phosphoryl)-thioacetimidic acid methyl ester; hydriodide

{[2-(Diethoxy-phosphoryl)-acetimidoyl]-methyl-amino}-acetic acid

{[2-(Diethoxy-phosphoryl)-acetimidoyl]-methyl-amino}-acetic acid

Conditions
ConditionsYield
With pyridine In dichloromethane at 260℃;99%
N-phenyl-maleimide
941-69-5

N-phenyl-maleimide

2-chloro-6-methoxyquinolin-3-carboxaldehyde
73568-29-3

2-chloro-6-methoxyquinolin-3-carboxaldehyde

sarcosine
107-97-1

sarcosine

(3aR,6aS)-4-(6-Methoxy-2-oxo-1,2-dihydro-quinolin-3-yl)-5-methyl-2-phenyl-tetrahydro-pyrrolo[3,4-c]pyrrole-1,3-dione

(3aR,6aS)-4-(6-Methoxy-2-oxo-1,2-dihydro-quinolin-3-yl)-5-methyl-2-phenyl-tetrahydro-pyrrolo[3,4-c]pyrrole-1,3-dione

Conditions
ConditionsYield
In xylene for 2h; Heating;99%
1-phenylmethyl-4-piperidone
3612-20-2

1-phenylmethyl-4-piperidone

sarcosine
107-97-1

sarcosine

2-[(1-benzyl-4-piperidyl)(methyl)amino]acetic acid
336191-70-9

2-[(1-benzyl-4-piperidyl)(methyl)amino]acetic acid

Conditions
ConditionsYield
With triethanolamine; acetic acid; trifluoroacetic acid In 1,2-dichloro-ethane99%
formaldehyd
50-00-0

formaldehyd

sarcosine
107-97-1

sarcosine

(E)-methyl-3-(benzo[d][1,3]dioxol-5-yl)-2-cyanoacrylate
117133-77-4

(E)-methyl-3-(benzo[d][1,3]dioxol-5-yl)-2-cyanoacrylate

methyl (3RS,4RS)-4-(1,3-benzodioxol-5-yl)-3-cyano-1-methylpyrrolidine-3-carboxylate

methyl (3RS,4RS)-4-(1,3-benzodioxol-5-yl)-3-cyano-1-methylpyrrolidine-3-carboxylate

Conditions
ConditionsYield
In toluene for 1.33333h; Reflux; stereospecific reaction;99%
formaldehyd
50-00-0

formaldehyd

sarcosine
107-97-1

sarcosine

methyl (E)- 2-cyano-3-(4-methoxyphenyl)prop-2-enoate
14479-58-4

methyl (E)- 2-cyano-3-(4-methoxyphenyl)prop-2-enoate

methyl (3RS,4RS)-3-cyano-4-(4-methoxyphenyl)-1-methylpyrrolidine-3-carboxylate

methyl (3RS,4RS)-3-cyano-4-(4-methoxyphenyl)-1-methylpyrrolidine-3-carboxylate

Conditions
ConditionsYield
In toluene for 1.25h; Reflux; stereospecific reaction;99%
sarcosine
107-97-1

sarcosine

α-naphthyl isoselenocyanate
912676-30-3

α-naphthyl isoselenocyanate

1-methyl-3-(1-naphthyl)-2-selenoxohydantoin
1310370-46-7

1-methyl-3-(1-naphthyl)-2-selenoxohydantoin

Conditions
ConditionsYield
In 1,4-dioxane at 100℃; for 3.5h;99%
sarcosine
107-97-1

sarcosine

1-benzylisatin
1217-89-6

1-benzylisatin

ethyl (2E)-(1-benzyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)acetate
13672-24-7

ethyl (2E)-(1-benzyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)acetate

C36H33N3O4

C36H33N3O4

Conditions
ConditionsYield
In ethanol at 20℃; for 2h; diastereoselective reaction;99%
sarcosine
107-97-1

sarcosine

1-benzylisatin
1217-89-6

1-benzylisatin

(3S*,5’S*)-1,1’’-dibenzyl-3’-methyldispiro[indoline-3,4’-oxazolidine-5’,3’’-indoline]-2,2’’-dione

(3S*,5’S*)-1,1’’-dibenzyl-3’-methyldispiro[indoline-3,4’-oxazolidine-5’,3’’-indoline]-2,2’’-dione

Conditions
ConditionsYield
In dimethyl sulfoxide at 20℃; for 4h; Green chemistry; diastereoselective reaction;99%
With 3-nitro-2-(trifluoromethyl)-2H-chromene In isopropyl alcohol at 55 - 60℃; for 5h;43%
formaldehyd
50-00-0

formaldehyd

4-phenylsulphonyl-2H-chromene-2-one
72167-88-5

4-phenylsulphonyl-2H-chromene-2-one

sarcosine
107-97-1

sarcosine

1,3-dihydro-2-methyl-pyrrolo(3,4-c)chromene-4-one
127599-33-1

1,3-dihydro-2-methyl-pyrrolo(3,4-c)chromene-4-one

Conditions
ConditionsYield
In benzene for 3h; Heating;98%
formaldehyd
50-00-0

formaldehyd

sarcosine
107-97-1

sarcosine

3-nitro-benzaldehyde
99-61-6

3-nitro-benzaldehyde

3-methyl-5-(3-nitro-phenyl)-oxazolidine

3-methyl-5-(3-nitro-phenyl)-oxazolidine

Conditions
ConditionsYield
In benzene for 1h; Heating;98%
(3E,5E)-1-methyl-3,5-bis(4-fluorobenzylidene)piperidin-4-one

(3E,5E)-1-methyl-3,5-bis(4-fluorobenzylidene)piperidin-4-one

sarcosine
107-97-1

sarcosine

acenaphthene quinone
82-86-0

acenaphthene quinone

1-methyl-4-(4-fluorophenyl)pyrrole(spiro[2.2'']acenaphthene-1''-one)-spiro[3.3']-5'-(4-fluorophenylmethylidene)-1'-methyltetrahydro-4'(1'H)-pyridinone

1-methyl-4-(4-fluorophenyl)pyrrole(spiro[2.2'']acenaphthene-1''-one)-spiro[3.3']-5'-(4-fluorophenylmethylidene)-1'-methyltetrahydro-4'(1'H)-pyridinone

Conditions
ConditionsYield
In methanol for 1h; Reflux; stereoselective reaction;98%
In methanol for 1h; Heating;97%
(3E,5E)-3,5-bis(2-chlorobenzylidene)-1-methylpiperidin-4-one

(3E,5E)-3,5-bis(2-chlorobenzylidene)-1-methylpiperidin-4-one

sarcosine
107-97-1

sarcosine

acenaphthene quinone
82-86-0

acenaphthene quinone

1-methyl-4-(2-chlorophenyl)pyrrole(spiro[2.2'']acenaphthene-1''-one)-spiro[3.3']-5'-(2-chlorophenylmethylidene)-1'-methyltetrahydro-4'(1'H)-pyridinone

1-methyl-4-(2-chlorophenyl)pyrrole(spiro[2.2'']acenaphthene-1''-one)-spiro[3.3']-5'-(2-chlorophenylmethylidene)-1'-methyltetrahydro-4'(1'H)-pyridinone

Conditions
ConditionsYield
In methanol for 1h; Heating;98%
C8H9NOC12H8F2

C8H9NOC12H8F2

sarcosine
107-97-1

sarcosine

acenaphthene quinone
82-86-0

acenaphthene quinone

1-methyl-4-(3-fluorophenyl)pyrrole(spiro[2.2'']acenaphthene-1''-one)-spiro[3.3']-5'-(3-fluorophenylmethylidene)-1'-methyltetrahydro-4'(1'H)-pyridinone

1-methyl-4-(3-fluorophenyl)pyrrole(spiro[2.2'']acenaphthene-1''-one)-spiro[3.3']-5'-(3-fluorophenylmethylidene)-1'-methyltetrahydro-4'(1'H)-pyridinone

Conditions
ConditionsYield
In methanol for 1h; Reflux; stereoselective reaction;98%
In methanol for 1h; Heating;96%
sarcosine
107-97-1

sarcosine

(E)-1-methyl-3,5-bis(4-methoxybenzylidene)-4-piperidone
4369-12-4

(E)-1-methyl-3,5-bis(4-methoxybenzylidene)-4-piperidone

acenaphthene quinone
82-86-0

acenaphthene quinone

1-methyl-4-(4-methoxyphenyl)pyrrole(spiro[2.2'']acenaphthene-1''-one)-spiro[3.3']-5'-(4-methoxyphenylmethylidene)-1'-methyltetrahydro-4'(1'H)-pyridinone

1-methyl-4-(4-methoxyphenyl)pyrrole(spiro[2.2'']acenaphthene-1''-one)-spiro[3.3']-5'-(4-methoxyphenylmethylidene)-1'-methyltetrahydro-4'(1'H)-pyridinone

Conditions
ConditionsYield
In methanol for 1h; Heating;98%
formaldehyd
50-00-0

formaldehyd

2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyridine-7-carbaldehyde
762173-03-5

2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyridine-7-carbaldehyde

sarcosine
107-97-1

sarcosine

2-(4-fluorophenyl)-7-(3-methyloxazolidin-5-yl)-3-(methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyridine
762173-04-6

2-(4-fluorophenyl)-7-(3-methyloxazolidin-5-yl)-3-(methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyridine

Conditions
ConditionsYield
In toluene for 12h; Heating;98%
sarcosine
107-97-1

sarcosine

p-chlorophenyl isoselenocyanate
14223-48-4

p-chlorophenyl isoselenocyanate

3-(p-chlorophenyl)-1-methyl-2-selenoxohydantoin
1310370-38-7

3-(p-chlorophenyl)-1-methyl-2-selenoxohydantoin

Conditions
ConditionsYield
In 1,4-dioxane at 100℃; for 5h;98%
sarcosine
107-97-1

sarcosine

C21H17NO
1353546-25-4

C21H17NO

5-chloroindole 2,3-dione
17630-76-1

5-chloroindole 2,3-dione

C31H26ClN3O2

C31H26ClN3O2

Conditions
ConditionsYield
In 1,4-dioxane; methanol Reflux; stereoselective reaction;98%
sarcosine
107-97-1

sarcosine

(E)-2-[4-chlorobenzylidene]-3,4-dihydro-1(2H)-acridinone
1353546-31-2

(E)-2-[4-chlorobenzylidene]-3,4-dihydro-1(2H)-acridinone

indole-2,3-dione
91-56-5

indole-2,3-dione

C30H24ClN3O2

C30H24ClN3O2

Conditions
ConditionsYield
In 1,4-dioxane; methanol for 6h; Reflux; stereoselective reaction;98%
sarcosine
107-97-1

sarcosine

2-(ethoxycarbonothioylthio)acetic acid
25554-84-1

2-(ethoxycarbonothioylthio)acetic acid

N-(ethoxycarbonothioyl)-N-methylglycine
59857-32-8

N-(ethoxycarbonothioyl)-N-methylglycine

Conditions
ConditionsYield
With sodium hydroxide In water at 20℃; for 48h;98%
With sodium hydroxide In water at 25℃; for 72h;
In water
With sodium hydroxide In water

Sarcosine History

Sarcosine was first isolated and named by the German chemist Justus von Liebig in 1847, while Jacob Volhard first synthesized it in 1862.

Sarcosine Specification

The Sarcosine is an amino acid intermediate in the metabolism of choline. The IUPAC name of this chemical is 2-(methylamino)acetic acid. With the CAS registry number 107-97-1, it is also named as Glycine, N-methyl-. The product's categories are amino acids series;sarcosine [sar];amino acids. It is white crystalline powder with a sweetish taste. And it is soluble in water, ethanol and dilute ethanol, insoluble in ether. Additionally, people should keep this chemical in cool and dry place and keep away from fire, heat and water.

The other characteristics of this product can be summarized as: (1)ACD/LogP: -0.79; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -3.29; (4)ACD/LogD (pH 7.4): -3.29; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 3; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 2; (12)Index of Refraction: 1.431; (13)Molar Refractivity: 21.1 cm3; (14)Molar Volume: 81.4 cm3; (15)Polarizability: 8.36×10-24 cm3; (16)Surface Tension: 37.1 dyne/cm; (17)Enthalpy of Vaporization: 47.54 kJ/mol; (18)Vapour Pressure: 0.184 mmHg at 25°C; (19)Rotatable Bond Count: 2; (20)Exact Mass: 89.047678; (21)MonoIsotopic Mass: 89.047678; (22)Topological Polar Surface Area: 49.3; (23)Heavy Atom Count: 6; (24)Complexity: 52.8.

Preparation of Sarcosine: Digesting the bark of Quillaia saponaria by hot water or aqueous ethanol, then using ether or acetone to make it precipitation. Finally, we can get the product by re-crystallization and refining.

Uses of Sarcosine: It is used as biochemical reagent, dye stabilizer, daily chemical, amino acid surfactants, health drugs fatigue recovery agent and so on. It also can react with ethanol to get N-methyl-glycine ethyl ester. This reaction needs reagent aqueous HCl.


 
When you are using this chemical, please be cautious about it as the following:
It is irritating to eyes, respiratory system and skin, so people should avoid contact with skin and eyes. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing.

People can use the following data to convert to the molecule structure.
1. SMILES:O=C(O)CNC
2. InChI:InChI=1/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6) 
3. InChIKey:FSYKKLYZXJSNPZ-UHFFFAOYAL

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