S-Adenosyl-L-methionine
glycine
sarcosine
Conditions | Yield |
---|---|
With recombinant mouse glycine N-methyltransferase In aq. buffer at 30℃; for 0.333333h; pH=8; Reagent/catalyst; Enzymatic reaction; |
Conditions | Yield |
---|---|
With trifluoroacetic acid In dichloromethane at 20℃; for 2h; |
Conditions | Yield |
---|---|
With water das entstechende Nitril wird durch konz. Salzsaeure verseift; | |
With water; sodium hydroxide at 25℃; for 1h; Inert atmosphere; | |
Stage #1: glycolonitrile; methylamine at 20℃; for 1h; Inert atmosphere; Stage #2: With water; sodium hydroxide |
sarcosine ethyl ester hydrochloride
sarcosine
Conditions | Yield |
---|---|
With bromine; triethylamine In dichloromethane; water; ethyl acetate |
Conditions | Yield |
---|---|
With sodium dihydrogenphosphate; zinc at 30℃; for 0.116667h; | 90% |
With hydrogenchloride; water |
O2-(2,4-dinitrophenyl) 1-[N-(carboxymethyl)-N-methylamino]diazen-1-ium-1,2-diolate
sarcosine
Conditions | Yield |
---|---|
With GLUTATHIONE; diethylenetriaminopentaacetic acid In dimethyl sulfoxide at 37℃; pH=7.4; aq. phosphate buffer; Inert atmosphere; |
Conditions | Yield |
---|---|
With Pseudomonas putida T5 glyphosate C-P lyase In aq. phosphate buffer at 30℃; pH=7; Kinetics; Enzymatic reaction; |
luzopeptin C
A
sarcosine
B
D-Serine
C
L-β-hydroxy-N-methylvaline
D
glycine
Conditions | Yield |
---|---|
With hydrogenchloride at 100℃; for 18h; Further byproducts given; |
luzopeptin C
A
sarcosine
B
D-Serine
C
3-hydroxy-6-methoxyquinoline-2-carboxylic acid
D
glycine
Conditions | Yield |
---|---|
With hydrogenchloride at 100℃; for 18h; Further byproducts given; |
hydrogen cyanide
A
sarcosine
B
glycine
C
rac-Ala-OH
D
3-amino propanoic acid
Conditions | Yield |
---|---|
With ammonia; water at -196℃; Further byproducts given; | A 0.24 mmol B 3.0 mmol C 0.18 mmol D 0.17 mmol |
Conditions | Yield |
---|---|
Bei langandauernder Faeulnis; | |
With barium dihydroxide at 100℃; im Rohr; |
Conditions | Yield |
---|---|
With water at 40℃; | |
With water |
N-methyl-N-phenylmethanesulfonyl-glycine
sarcosine
Conditions | Yield |
---|---|
With hydrogenchloride Hydrolysis.im geschlossenen Rohr; |
methane
ammonia
water
A
sarcosine
B
glycine
C
2-aminobutanoic acid
Conditions | Yield |
---|---|
With hydrogen byproducts: dl-α-amino-butiric acid, dl-alanine, β-alanine; by electric spark discharge or electric discharge; |
C10H22N2O
A
sarcosine
B
(R)-2-heptylamine(R)-2-heptylamine
Conditions | Yield |
---|---|
With novozyme 435; water at 70℃; for 147h; pH=7; aq. phosphate buffer; Enzymatic reaction; |
Conditions | Yield |
---|---|
With novozyme 435; water at 70℃; for 120h; pH=7; aq. phosphate buffer; Enzymatic reaction; |
A
sarcosine
B
L-β-hydroxy-N-methylvaline
C
(R)-3-Hydroxy-2-[(3-hydroxy-6-methoxy-quinoline-2-carbonyl)-amino]-propionic acid
Conditions | Yield |
---|---|
With water; hydroxide |
Conditions | Yield |
---|---|
With ammonia Yield given. Further byproducts given. Yields of byproduct given; |
N-nitrososarcosine
sarcosine
Conditions | Yield |
---|---|
With sodium azide; sulfuric acid; SC(NH2)2 In water; acetic acid at 25℃; Rate constant; other solvent; other catalysts; | |
With perchloric acid; ammonium sulfamate; sodium thiocyanide at 50℃; Rate constant; piperidinium perchlorate, 18h; transnitrosating studies; |
methylamine
A
sarcosine
B
glycine
C
rac-Ala-OH
D
3-amino propanoic acid
Conditions | Yield |
---|---|
With ammonia Yield given. Further byproducts given. Yields of byproduct given; |
glycine
A
sarcosine
B
N-methylglycine methylester
C
glycylglycine
D
iminodiacetic acid
Conditions | Yield |
---|---|
With 5%-palladium/activated carbon; hydrogen at 180℃; under 300.03 Torr; for 0.166667h; |
2-(N-methylphenylsulfonamido)acetic acid
sarcosine
Conditions | Yield |
---|---|
With sulfuric acid at 125 - 130℃; |
methoxycarbonylmethylamine
A
morpholine-2,5-dione
B
sarcosine
C
N-methylglycine methylester
D
dimethyl iminodiacetate
E
glycine
Conditions | Yield |
---|---|
With 5%-palladium/activated carbon; hydrogen at 180℃; under 300.03 Torr; for 0.166667h; |
C16H19N2O4P
A
sarcosine
B
phosphoric acid monophenyl ester
C
p-toluidine
Conditions | Yield |
---|---|
With hydrogenchloride In 1,4-dioxane for 0.0833333h; |
Conditions | Yield |
---|---|
With hydrogenchloride at 110℃; for 15h; Further byproducts. Title compound not separated from byproducts.; |
formamide
sarcosine
Conditions | Yield |
---|---|
With Canyon Diablo iron meteorites at 140℃; for 24h; Reagent/catalyst; Temperature; |
Conditions | Yield |
---|---|
With barium dihydroxide; water | |
With barium dihydroxide |
Conditions | Yield |
---|---|
With barium dihydroxide; water | |
With barium dihydroxide |
A
sarcosine
B
O-methyl-L-threonine
C
o-hydroxyl-phenylalanine
D
cis-4-methyl-(S)-proline
Conditions | Yield |
---|---|
With hydrogenchloride; water at 130℃; |
Conditions | Yield |
---|---|
With thionyl chloride at 0 - 78℃; | 100% |
With hydrogenchloride | 99% |
With hydrogenchloride at 20℃; for 72h; | 95% |
With hydrogenchloride | |
With acetyl chloride for 3h; Reflux; |
Conditions | Yield |
---|---|
With sodium carbonate In 1,4-dioxane; water at 20℃; | 100% |
With sodium carbonate In 1,4-dioxane; water 1.) 0 deg C, 1.5 h, 2.) room temperature, 11 h; | 99% |
With sodium hydroxide In water at 0 - 20℃; for 16h; | 94% |
Conditions | Yield |
---|---|
With thionyl chloride for 6.5h; Cooling; Reflux; Inert atmosphere; | 100% |
With thionyl chloride at 55℃; for 2h; | 92% |
With thionyl chloride 1.) ice-salt bath, 20 min, 2.) room temperature, 2 h, 3.) reflux, 2 h; | 90% |
Conditions | Yield |
---|---|
With triethylamine In water for 6h; | 100% |
With triethylamine In water at 25℃; for 3h; | 97% |
With sodium hydroxide In 1,4-dioxane | 95% |
Conditions | Yield |
---|---|
With hydrogenchloride; sodium hydroxide; sodium perchlorate; chlorine at 24.9℃; Mechanism; Rate constant; Equilibrium constant; multistep reaction: 1.) water, 298 deg K, 2.) water, 298 deg K; reactions under var. conditions; | A 100% B n/a C n/a |
formaldehyd
sarcosine
2-nitro-benzaldehyde
3-methyl-5-(2'-nitrophenyl)oxazolidine
Conditions | Yield |
---|---|
In toluene for 1h; Heating; | 100% |
In benzene for 1h; Heating; | 95% |
sarcosine
zinc diacetate
fullerene-C60
[Zn(C20H8N4((C4H9)2C6H3)3(C6H4)(C10H2N2O4)(C6H4)(CH3NC2H3)C60)]
Conditions | Yield |
---|---|
In toluene C60, C20H10N4((C4H9)2C6H3)3(C6H4)2(C10H2N2O4)(CHO), N-methylglycine (toluene) heated under N2 in dark for 6 h; cooled to 25°C, evapd. to dryness (reduced pressure); chromy. sepd., dissolved (CH3Cl), added Zn(OAc)2 in CH3OH, heated for 30 min; washed twice (H2O), dried (anhydrous Na2SO4), solvent evapd., chromy., reprecipitated from benzene-methanol; | 100% |
Conditions | Yield |
---|---|
In benzene for 5h; Reflux; Dean-Stark; diastereoselective reaction; | 100% |
Conditions | Yield |
---|---|
In methanol at 20℃; | 99.01% |
Conditions | Yield |
---|---|
With thionyl chloride at 0℃; for 3.5h; | 99% |
With thionyl chloride | |
(i) SOCl2, (ii) /BRN= 1098229/; Multistep reaction; | |
at 0 - 20℃; for 12h; |
sarcosine
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 260℃; | 99% |
N-phenyl-maleimide
2-chloro-6-methoxyquinolin-3-carboxaldehyde
sarcosine
Conditions | Yield |
---|---|
In xylene for 2h; Heating; | 99% |
1-phenylmethyl-4-piperidone
sarcosine
2-[(1-benzyl-4-piperidyl)(methyl)amino]acetic acid
Conditions | Yield |
---|---|
With triethanolamine; acetic acid; trifluoroacetic acid In 1,2-dichloro-ethane | 99% |
formaldehyd
sarcosine
(E)-methyl-3-(benzo[d][1,3]dioxol-5-yl)-2-cyanoacrylate
Conditions | Yield |
---|---|
In toluene for 1.33333h; Reflux; stereospecific reaction; | 99% |
formaldehyd
sarcosine
methyl (E)- 2-cyano-3-(4-methoxyphenyl)prop-2-enoate
Conditions | Yield |
---|---|
In toluene for 1.25h; Reflux; stereospecific reaction; | 99% |
sarcosine
α-naphthyl isoselenocyanate
1-methyl-3-(1-naphthyl)-2-selenoxohydantoin
Conditions | Yield |
---|---|
In 1,4-dioxane at 100℃; for 3.5h; | 99% |
sarcosine
1-benzylisatin
ethyl (2E)-(1-benzyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)acetate
Conditions | Yield |
---|---|
In ethanol at 20℃; for 2h; diastereoselective reaction; | 99% |
Conditions | Yield |
---|---|
In dimethyl sulfoxide at 20℃; for 4h; Green chemistry; diastereoselective reaction; | 99% |
With 3-nitro-2-(trifluoromethyl)-2H-chromene In isopropyl alcohol at 55 - 60℃; for 5h; | 43% |
formaldehyd
4-phenylsulphonyl-2H-chromene-2-one
sarcosine
1,3-dihydro-2-methyl-pyrrolo(3,4-c)chromene-4-one
Conditions | Yield |
---|---|
In benzene for 3h; Heating; | 98% |
Conditions | Yield |
---|---|
In benzene for 1h; Heating; | 98% |
Conditions | Yield |
---|---|
In methanol for 1h; Reflux; stereoselective reaction; | 98% |
In methanol for 1h; Heating; | 97% |
Conditions | Yield |
---|---|
In methanol for 1h; Heating; | 98% |
Conditions | Yield |
---|---|
In methanol for 1h; Reflux; stereoselective reaction; | 98% |
In methanol for 1h; Heating; | 96% |
sarcosine
(E)-1-methyl-3,5-bis(4-methoxybenzylidene)-4-piperidone
acenaphthene quinone
Conditions | Yield |
---|---|
In methanol for 1h; Heating; | 98% |
formaldehyd
2-(4-fluorophenyl)-3-(2-methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyridine-7-carbaldehyde
sarcosine
2-(4-fluorophenyl)-7-(3-methyloxazolidin-5-yl)-3-(methylsulfanylpyrimidin-4-yl)imidazo[1,2-a]pyridine
Conditions | Yield |
---|---|
In toluene for 12h; Heating; | 98% |
sarcosine
p-chlorophenyl isoselenocyanate
3-(p-chlorophenyl)-1-methyl-2-selenoxohydantoin
Conditions | Yield |
---|---|
In 1,4-dioxane at 100℃; for 5h; | 98% |
Conditions | Yield |
---|---|
In 1,4-dioxane; methanol Reflux; stereoselective reaction; | 98% |
sarcosine
(E)-2-[4-chlorobenzylidene]-3,4-dihydro-1(2H)-acridinone
indole-2,3-dione
Conditions | Yield |
---|---|
In 1,4-dioxane; methanol for 6h; Reflux; stereoselective reaction; | 98% |
sarcosine
2-(ethoxycarbonothioylthio)acetic acid
N-(ethoxycarbonothioyl)-N-methylglycine
Conditions | Yield |
---|---|
With sodium hydroxide In water at 20℃; for 48h; | 98% |
With sodium hydroxide In water at 25℃; for 72h; | |
In water | |
With sodium hydroxide In water |
The Sarcosine is an amino acid intermediate in the metabolism of choline. The IUPAC name of this chemical is 2-(methylamino)acetic acid. With the CAS registry number 107-97-1, it is also named as Glycine, N-methyl-. The product's categories are amino acids series;sarcosine [sar];amino acids. It is white crystalline powder with a sweetish taste. And it is soluble in water, ethanol and dilute ethanol, insoluble in ether. Additionally, people should keep this chemical in cool and dry place and keep away from fire, heat and water.
The other characteristics of this product can be summarized as: (1)ACD/LogP: -0.79; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -3.29; (4)ACD/LogD (pH 7.4): -3.29; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 3; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 2; (12)Index of Refraction: 1.431; (13)Molar Refractivity: 21.1 cm3; (14)Molar Volume: 81.4 cm3; (15)Polarizability: 8.36×10-24 cm3; (16)Surface Tension: 37.1 dyne/cm; (17)Enthalpy of Vaporization: 47.54 kJ/mol; (18)Vapour Pressure: 0.184 mmHg at 25°C; (19)Rotatable Bond Count: 2; (20)Exact Mass: 89.047678; (21)MonoIsotopic Mass: 89.047678; (22)Topological Polar Surface Area: 49.3; (23)Heavy Atom Count: 6; (24)Complexity: 52.8.
Preparation of Sarcosine: Digesting the bark of Quillaia saponaria by hot water or aqueous ethanol, then using ether or acetone to make it precipitation. Finally, we can get the product by re-crystallization and refining.
Uses of Sarcosine: It is used as biochemical reagent, dye stabilizer, daily chemical, amino acid surfactants, health drugs fatigue recovery agent and so on. It also can react with ethanol to get N-methyl-glycine ethyl ester. This reaction needs reagent aqueous HCl.
When you are using this chemical, please be cautious about it as the following:
It is irritating to eyes, respiratory system and skin, so people should avoid contact with skin and eyes. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing.
People can use the following data to convert to the molecule structure.
1. SMILES:O=C(O)CNC
2. InChI:InChI=1/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6)
3. InChIKey:FSYKKLYZXJSNPZ-UHFFFAOYAL
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