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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid

Cas:1012341-50-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for the fine c

(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid

Cas:1012341-50-2

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid CAS 1012341-50-2 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceuti

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid CAS 1012341-50-2

Cas:1012341-50-2

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Hangzhou Think Chemical Co. Ltd

(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid CAS No.:1012341-50-2 Name: (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid Molecular Structu

Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid

Cas:1012341-50-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

Hebei yanxi chemical co., LTD is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low carb

(R)-tert-butyl (1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbaMate

Cas:1012341-50-2

Min.Order:1 Kilogram

FOB Price: $1.0 / 3.0

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid

Cas:1012341-50-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com/pro01en/id/942.html Product Name (2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid

(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid

Cas:1012341-50-2

Min.Order:1 Gram

FOB Price: $66.0

Type:Lab/Research institutions

inquiry

Ality Chemical Corporation

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid Basic information Product Name: (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid Synonyms: (2R,4S)-5-([1,1'

Factory Supply Sacubitril Impurity 8

Cas:1012341-50-2

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

LIDE PHARMACEUTICALS LIMITED

LIDE PHARMACEUTICALS LIMITED is a professional chemicals and APIs leading manufacturer in China. Our core business line covers APIs, Intermediates, Herb extract, etc.

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid

Cas:1012341-50-2

Min.Order:1 Kilogram

FOB Price: $0.6 / 1.0

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our Advantage Rich Experience Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. Quality service Company cooperates with research institutes. We strictly con

(2R, 4S) -5- (Biphenyl-4-yl) -4-[ (tert-butoxycarbonyl) Amino]-2-Methylpentanoic Acid CAS 1012341-50-2

Cas:1012341-50-2

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid 1012341-50-2

Cas:1012341-50-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 1012341-50-2 with best quality

Cas:1012341-50-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-meth

Cas:1012341-50-2

Min.Order:10 Kilogram

FOB Price: $80.0 / 100.0

Type:Trading Company

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available ♦ W

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid:cas:1012341-50-2

Cas:1012341-50-2

Min.Order:1 Metric Ton

FOB Price: $20.0 / 30.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Name: 2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid Synonyms: (2r,4s)-5-(biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid CAS:1012341-50-2 MF: C23H29NO4 Appearance: white powder Stor

2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

Cas:1012341-50-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hubei Langyou International Trading Co., Ltd

Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid 1012341-50-2

Cas:1012341-50-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

HANWAYS CHEMPHARM CO.,LIMITED

Hanways Chempharm Co., Limited, the former is Hubei Hanways Pharchem CO.,Limited, set up in 2009 in Wuhan, China. We specialize in sourcing and supplying APIs, pharmaceutical intermediates, and fine chemicals for worldwide markets. The founder has d

(2R,4S)-5-([1,1-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

Cas:1012341-50-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

Hangzhou Huarong Pharm Co., Ltd. established since 2009 , has been always focusing on supplying products and services to our clients in the field of small molecule drug. Huarong Pharm has built platforms for the research, development and manufac

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid

Cas:1012341-50-2

Min.Order:1 Gram

FOB Price: $1.0 / 2.0

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid Chemical Properties Boiling point 582.6±50.0 °C(Predicted) density 1.115±0.06 g/cm3(Predicted) storage temp. 2-8°C pka 4 +

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid.

Cas:1012341-50-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid

Cas:1012341-50-2

Min.Order:1 Kilogram

FOB Price: $120.0 / 134.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid CAS:1012341-50-2 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and tr

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid CAS:1012341-50-2

Cas:1012341-50-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid

Cas:1012341-50-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

CAS 1012341-50-2(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid

Cas:1012341-50-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid

Cas:1012341-50-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By

(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid

Cas:1012341-50-2

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-meth

Cas:1012341-50-2

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

(2R,4S)-5-([1,1'-BIPHENYL]-4-YL)-4-((TERT-BUTOXYCARBONYL)AMINO)-2-METHYLPENTANOIC ACID

Cas:1012341-50-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

C33H38N2O5

C33H38N2O5

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

Conditions
ConditionsYield
Stage #1: C33H38N2O5 With dihydrogen peroxide In tetrahydrofuran at 0℃; for 0.5h;
Stage #2: With lithium hydroxide at 25 - 30℃; for 3h;
95%
(2E,4R)-5-{[1,1'-biphenyl]-4-yl}-4-{[(tert-butoxy)carbonyl]amino}-2-methylpent-2-enoic acid
1012341-48-8

(2E,4R)-5-{[1,1'-biphenyl]-4-yl}-4-{[(tert-butoxy)carbonyl]amino}-2-methylpent-2-enoic acid

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

Conditions
ConditionsYield
With ammonium formate; nickel(II) acetate tetrahydrate; (R,R)-N,N'-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediamine In ethanol at 55℃; for 8h; Temperature;91.9%
With hydrogen under 15001.5 - 18751.9 Torr;90%
With hydrogen; diiodo(p-cymene)ruthenium(II) dimer; (SP,S′P)-1,1′-bis[bis(4-methoxy-3,5-dimethylphenyl)phosphino]-2,2′-bis[(R)-α-(dimethylamino)benzyl]ferrocene In ethanol at 40℃; under 15001.5 Torr; for 6h; Product distribution / selectivity;86.9%
C33H38N2O5

C33H38N2O5

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

Conditions
ConditionsYield
Stage #1: C33H38N2O5 With dihydrogen peroxide In tetrahydrofuran at 0℃; for 0.5h;
Stage #2: With lithium hydroxide In tetrahydrofuran; water at 20 - 25℃; for 3h;
90%
(3R,5S)-5-biphenyl-4-ylmethyl-3-methyl-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester
1038924-76-3

(3R,5S)-5-biphenyl-4-ylmethyl-3-methyl-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

Conditions
ConditionsYield
With sodium hydroxide at 60℃; Reagent/catalyst;86%
Stage #1: (3R,5S)-5-biphenyl-4-ylmethyl-3-methyl-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester With lithium hydroxide In tetrahydrofuran; water at 20℃; for 1h;
Stage #2: With phosphoric acid In tetrahydrofuran; water Product distribution / selectivity;
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(R)-2-methyl-4-hydroxyimino-5-(4-biphenyl)pentanoic acid

(R)-2-methyl-4-hydroxyimino-5-(4-biphenyl)pentanoic acid

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

Conditions
ConditionsYield
Stage #1: (R)-2-methyl-4-hydroxyimino-5-(4-biphenyl)pentanoic acid With ((+)-(1R)-[1,1'-binaphthalene]-2,2'-diylbis[diphenylphosphine-κP])chloro[(1,2,3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene]ruthenium(1+) chloride; hydrogen In methanol at 40℃; under 30003 Torr; Autoclave;
Stage #2: di-tert-butyl dicarbonate With lithium hydroxide Reflux; diastereoselective reaction;
80%
(R)-5-(biphenyl-4-yl)-4-tert-butoxycarbonylamino-2-methylpent-2-enoic acid
149709-68-2

(R)-5-(biphenyl-4-yl)-4-tert-butoxycarbonylamino-2-methylpent-2-enoic acid

cyclohexylamine
108-91-8

cyclohexylamine

A

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

B

(2S,4S)-5-biphenyl-4-yl-(4-tert-butoxycarbonylamino)-2-methylpentanoic acid cyclohexylamine salt

(2S,4S)-5-biphenyl-4-yl-(4-tert-butoxycarbonylamino)-2-methylpentanoic acid cyclohexylamine salt

Conditions
ConditionsYield
Stage #1: (R)-5-(biphenyl-4-yl)-4-tert-butoxycarbonylamino-2-methylpent-2-enoic acid With palladium 10% on activated carbon; hydrogen In ethanol; water at 40℃; under 3750.38 Torr; for 3h;
Stage #2: cyclohexylamine In Isopropyl acetate at 70℃;
A 58%
B 10%
(2R/S,4S)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpentanoic acid

(2R/S,4S)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpentanoic acid

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

Conditions
ConditionsYield
With (S)-1-(1-Naphthyl)ethylamine In methanol at 60℃; for 1h; Temperature;37%
With (S)-1-phenyl-ethylamine In ethanol at 20℃; for 2h;
(2E,4R)-5-{[1,1'-biphenyl]-4-yl}-4-{[(tert-butoxy)carbonyl]amino}-2-methylpent-2-enoic acid
1012341-48-8

(2E,4R)-5-{[1,1'-biphenyl]-4-yl}-4-{[(tert-butoxy)carbonyl]amino}-2-methylpent-2-enoic acid

A

(2S,4S)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpentanoic acid

(2S,4S)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpentanoic acid

B

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

Conditions
ConditionsYield
With diiodo(p-cymene)ruthenium(II) dimer; (SP,S′P)-1,1′-bis[bis(4-methoxy-3,5-dimethylphenyl)phosphino]-2,2′-bis[(R)-α-(dimethylamino)benzyl]ferrocene; hydrogen In ethanol at 75℃; under 22502.3 Torr;A 5.3%
B 93.66 %Chromat.
With diiodo(p-cymene)ruthenium(II) dimer; (SP,S′P)-1,1′-bis[bis(4-methoxy-3,5-dimethylphenyl)phosphino]-2,2′-bis[(R)-α-(dimethylamino)benzyl]ferrocene; hydrogen In dichloromethane; water at 60℃; under 45004.5 Torr; for 16h; Autoclave; Ionic liquid; Inert atmosphere;A n/a
B n/a
(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid hydrochloride
1038924-71-8

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid hydrochloride

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

Conditions
ConditionsYield
Stage #1: (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid hydrochloride; di-tert-butyl dicarbonate With potassium carbonate In water; isopropyl alcohol at 20℃; for 1h;
Stage #2: With phosphoric acid In water; isopropyl alcohol Product distribution / selectivity;
(3R,5S)-5-biphenyl-4-ylmethyl-3-methyl-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester
1038924-76-3

(3R,5S)-5-biphenyl-4-ylmethyl-3-methyl-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester

A

(2S,4S)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpentanoic acid

(2S,4S)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpentanoic acid

B

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydride; potassium hexamethylsilazane / toluene / 1 h / -15 °C
1.2: 0.5 h / -15 °C
1.3: 1 h / 20 °C
2.1: water; lithium hydroxide / tetrahydrofuran / 20 h / 20 °C
3.1: triethylamine; hydrogen / 5% rhodium-on-charcoal / Isopropyl acetate / 20 °C / 760.05 Torr
View Scheme
Multi-step reaction with 3 steps
1.1: sodium hydride; potassium hexamethylsilazane / toluene; mineral oil / 1 h / -15 °C
1.2: 0.5 h / -15 °C
1.3: 1 h / 20 °C
2.1: lithium hydroxide; water / tetrahydrofuran / 20 h / 20 °C
3.1: hydrogen; triethylamine; 10% Pt/activated carbon / Isopropyl acetate / 20 °C / 760.05 Torr
View Scheme
(R)-5-biphenyl-4-ylmethyl-3-methylene-2-oxo-pyrrolidine-1-carboxylic acid tert-butylester
1174130-72-3

(R)-5-biphenyl-4-ylmethyl-3-methylene-2-oxo-pyrrolidine-1-carboxylic acid tert-butylester

A

(2S,4S)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpentanoic acid

(2S,4S)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpentanoic acid

B

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium(0); triphenylphosphine / xylene / Reflux
2: water; lithium hydroxide / tetrahydrofuran / 20 h / 20 °C
3: triethylamine; hydrogen / 5% rhodium-on-charcoal / Isopropyl acetate / 20 °C / 760.05 Torr
View Scheme
Multi-step reaction with 3 steps
1: tetrakis(triphenylphosphine) palladium(0); triphenylphosphine; sodium hydrogencarbonate / 5,5-dimethyl-1,3-cyclohexadiene / Reflux
2: lithium hydroxide; water / tetrahydrofuran / 20 h / 20 °C
3: hydrogen; triethylamine; 10% Pt/activated carbon / Isopropyl acetate / 20 °C / 760.05 Torr
View Scheme
(Z)-(R)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpent-2-enoic acid
1361408-16-3

(Z)-(R)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpent-2-enoic acid

A

(2S,4S)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpentanoic acid

(2S,4S)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpentanoic acid

B

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

Conditions
ConditionsYield
With hydrogen; triethylamine; 5% rhodium-on-charcoal In Isopropyl acetate at 20℃; under 760.051 Torr; Product distribution / selectivity;
With hydrogen; triethylamine; palladium 10% on activated carbon In Isopropyl acetate at 20℃; under 760.051 Torr; Product distribution / selectivity;
With palladium 10% on activated carbon; hydrogen; triethylamine In Isopropyl acetate at 20℃; under 760.051 Torr; Reagent/catalyst;
With 10% Pt/activated carbon; hydrogen; triethylamine In Isopropyl acetate at 20℃; under 760.051 Torr; Reagent/catalyst;
(R)-5-biphenyl-4-ylmethyl-3-methyl-2-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester
1361408-15-2

(R)-5-biphenyl-4-ylmethyl-3-methyl-2-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester

A

(2S,4S)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpentanoic acid

(2S,4S)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpentanoic acid

B

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: water; lithium hydroxide / tetrahydrofuran / 20 h / 20 °C
2: triethylamine; hydrogen / 5% rhodium-on-charcoal / Isopropyl acetate / 20 °C / 760.05 Torr
View Scheme
C19H27NO5

C19H27NO5

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: bis(dicyclopentadiene)rhodium tetrafluoroborate; C52H44N2O2P2; hydrogen / methanol / 50 °C / Autoclave
2: pyridine / dichloromethane / 0.17 h / -17 - -15 °C
3: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / toluene / 80 °C / Inert atmosphere
4: lithium hydroxide; water / ethanol / 70 °C
View Scheme
ethyl(2S,4S)-4-((tert-butoxycarbonyl)amino)-5-(4-hydroxyphenyl)-2-methylpentanoate

ethyl(2S,4S)-4-((tert-butoxycarbonyl)amino)-5-(4-hydroxyphenyl)-2-methylpentanoate

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: pyridine / dichloromethane / 0.17 h / -17 - -15 °C
2: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / toluene / 80 °C / Inert atmosphere
3: lithium hydroxide; water / ethanol / 70 °C
View Scheme
(2S,4S)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpentanoic acid ethyl ester
149709-61-5

(2S,4S)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpentanoic acid ethyl ester

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

Conditions
ConditionsYield
With water; lithium hydroxide In ethanol at 70℃;
N-(tert-butoxycarbonyl)-D-tyrosine
70642-86-3

N-(tert-butoxycarbonyl)-D-tyrosine

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: benzotriazol-1-ol; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / 37.5 - 75.01 Torr
2: lithium aluminium tetrahydride / diethyl ether / 0 °C
3: dichloromethane / 20 - 25 °C
4: bis(dicyclopentadiene)rhodium tetrafluoroborate; C52H44N2O2P2; hydrogen / methanol / 50 °C / Autoclave
5: pyridine / dichloromethane / 0.17 h / -17 - -15 °C
6: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / toluene / 80 °C / Inert atmosphere
7: lithium hydroxide; water / ethanol / 70 °C
View Scheme
tert-butyl (R)-3-(4-hydroxyphenyl)-1-[methoxy(methyl)amino]-1-oxopropan-2-ylcarbamate
929872-80-0

tert-butyl (R)-3-(4-hydroxyphenyl)-1-[methoxy(methyl)amino]-1-oxopropan-2-ylcarbamate

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: lithium aluminium tetrahydride / diethyl ether / 0 °C
2: dichloromethane / 20 - 25 °C
3: bis(dicyclopentadiene)rhodium tetrafluoroborate; C52H44N2O2P2; hydrogen / methanol / 50 °C / Autoclave
4: pyridine / dichloromethane / 0.17 h / -17 - -15 °C
5: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / toluene / 80 °C / Inert atmosphere
6: lithium hydroxide; water / ethanol / 70 °C
View Scheme
C14H19NO4

C14H19NO4

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: dichloromethane / 20 - 25 °C
2: bis(dicyclopentadiene)rhodium tetrafluoroborate; C52H44N2O2P2; hydrogen / methanol / 50 °C / Autoclave
3: pyridine / dichloromethane / 0.17 h / -17 - -15 °C
4: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / toluene / 80 °C / Inert atmosphere
5: lithium hydroxide; water / ethanol / 70 °C
View Scheme
(2R,4S)-5-(4-bromophenyl)-4-(tert-butoxycarbonyl) amino-2-methylpentanoic acid

(2R,4S)-5-(4-bromophenyl)-4-(tert-butoxycarbonyl) amino-2-methylpentanoic acid

phenylboronic acid
98-80-6

phenylboronic acid

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

Conditions
ConditionsYield
With dipotassium hydrogenphosphate; formic acid; palladium diacetate In water at 25 - 45℃; for 6h; Inert atmosphere;8 g
(2R)-3-(4-bromophenyl)-2-[[(tert-butoxy)carbonyl]amino]propanoic acid

(2R)-3-(4-bromophenyl)-2-[[(tert-butoxy)carbonyl]amino]propanoic acid

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: sodium tetrahydroborate / ethanol / 4 h / 25 - 35 °C
2: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium bromide; sodium hypochlorite solution / ethyl acetate; water / 2 h
3: ethyl acetate / 2 h / 25 - 35 °C
4: lithium hydroxide / ethanol; water / 3 h / 50 - 85 °C
5: diiodo(p-cymene)ruthenium(II) dimer; (α,α)2,2'-bis(α-N,N-dimethylaminophenylmethyl)-(S,S)-1,1'-bis-[di(3,5-dimethyl-4-methoxyphenyl)-phosphino]ferrocene; hydrogen / methanol / 7 h / 55 - 65 °C / 11251.1 - 15001.5 Torr / Autoclave; Inert atmosphere
6: formic acid; dipotassium hydrogenphosphate; palladium diacetate / water / 6 h / 25 - 45 °C / Inert atmosphere
View Scheme
tert-butyl [(2R)-1-(4-bromophenyl)-3-hydroxypropan-2-yl] carbamate

tert-butyl [(2R)-1-(4-bromophenyl)-3-hydroxypropan-2-yl] carbamate

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium bromide; sodium hypochlorite solution / ethyl acetate; water / 2 h
2: ethyl acetate / 2 h / 25 - 35 °C
3: lithium hydroxide / ethanol; water / 3 h / 50 - 85 °C
4: diiodo(p-cymene)ruthenium(II) dimer; (α,α)2,2'-bis(α-N,N-dimethylaminophenylmethyl)-(S,S)-1,1'-bis-[di(3,5-dimethyl-4-methoxyphenyl)-phosphino]ferrocene; hydrogen / methanol / 7 h / 55 - 65 °C / 11251.1 - 15001.5 Torr / Autoclave; Inert atmosphere
5: formic acid; dipotassium hydrogenphosphate; palladium diacetate / water / 6 h / 25 - 45 °C / Inert atmosphere
View Scheme
(2R)-2-amino-3-(4-bromophenyl)propanoic acid
62561-74-4

(2R)-2-amino-3-(4-bromophenyl)propanoic acid

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: thiophosgene / methanol / 4 h / 60 - 65 °C
1.2: 6 h / 25 - 35 °C
2.1: sodium tetrahydroborate / ethanol / 4 h / 25 - 35 °C
3.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium bromide; sodium hypochlorite solution / ethyl acetate; water / 2 h
4.1: ethyl acetate / 2 h / 25 - 35 °C
5.1: lithium hydroxide / ethanol; water / 3 h / 50 - 85 °C
6.1: diiodo(p-cymene)ruthenium(II) dimer; (α,α)2,2'-bis(α-N,N-dimethylaminophenylmethyl)-(S,S)-1,1'-bis-[di(3,5-dimethyl-4-methoxyphenyl)-phosphino]ferrocene; hydrogen / methanol / 7 h / 55 - 65 °C / 11251.1 - 15001.5 Torr / Autoclave; Inert atmosphere
7.1: formic acid; dipotassium hydrogenphosphate; palladium diacetate / water / 6 h / 25 - 45 °C / Inert atmosphere
View Scheme
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: thiophosgene / methanol / 4 h / 60 - 65 °C
1.2: 6 h / 25 - 35 °C
2.1: sodium tetrahydroborate / ethanol / 4 h / 25 - 35 °C
3.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; sodium bromide; sodium hypochlorite solution / ethyl acetate; water / 2 h
4.1: ethyl acetate / 2 h / 25 - 35 °C
5.1: lithium hydroxide / ethanol; water / 3 h / 50 - 85 °C
6.1: diiodo(p-cymene)ruthenium(II) dimer; (α,α)2,2'-bis(α-N,N-dimethylaminophenylmethyl)-(S,S)-1,1'-bis-[di(3,5-dimethyl-4-methoxyphenyl)-phosphino]ferrocene; hydrogen / methanol / 7 h / 55 - 65 °C / 11251.1 - 15001.5 Torr / Autoclave; Inert atmosphere
7.1: formic acid; dipotassium hydrogenphosphate; palladium diacetate / water / 6 h / 25 - 45 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: dmap / 20 °C
2: sodium hydroxide / 60 °C
View Scheme
tert-butyl [(2R)-1-(4-bromophenyl)-3-oxypropan-2-yl] carbamate
1246363-08-5

tert-butyl [(2R)-1-(4-bromophenyl)-3-oxypropan-2-yl] carbamate

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: ethyl acetate / 2 h / 25 - 35 °C
2: lithium hydroxide / ethanol; water / 3 h / 50 - 85 °C
3: diiodo(p-cymene)ruthenium(II) dimer; (α,α)2,2'-bis(α-N,N-dimethylaminophenylmethyl)-(S,S)-1,1'-bis-[di(3,5-dimethyl-4-methoxyphenyl)-phosphino]ferrocene; hydrogen / methanol / 7 h / 55 - 65 °C / 11251.1 - 15001.5 Torr / Autoclave; Inert atmosphere
4: formic acid; dipotassium hydrogenphosphate; palladium diacetate / water / 6 h / 25 - 45 °C / Inert atmosphere
View Scheme
ethyl (2E, 4R)-5-(4-bromophenyl)-4-[(tert-butoxycarbonyl) amino]-2-methylpent-enoate
1257266-88-8

ethyl (2E, 4R)-5-(4-bromophenyl)-4-[(tert-butoxycarbonyl) amino]-2-methylpent-enoate

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: lithium hydroxide / ethanol; water / 3 h / 50 - 85 °C
2: diiodo(p-cymene)ruthenium(II) dimer; (α,α)2,2'-bis(α-N,N-dimethylaminophenylmethyl)-(S,S)-1,1'-bis-[di(3,5-dimethyl-4-methoxyphenyl)-phosphino]ferrocene; hydrogen / methanol / 7 h / 55 - 65 °C / 11251.1 - 15001.5 Torr / Autoclave; Inert atmosphere
3: formic acid; dipotassium hydrogenphosphate; palladium diacetate / water / 6 h / 25 - 45 °C / Inert atmosphere
View Scheme
(2E,4R)-5-(4-bromophenyl)-4-[(tert-butoxycarbonyl) amino-2-methylpent-2-enoic acid]

(2E,4R)-5-(4-bromophenyl)-4-[(tert-butoxycarbonyl) amino-2-methylpent-2-enoic acid]

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: diiodo(p-cymene)ruthenium(II) dimer; (α,α)2,2'-bis(α-N,N-dimethylaminophenylmethyl)-(S,S)-1,1'-bis-[di(3,5-dimethyl-4-methoxyphenyl)-phosphino]ferrocene; hydrogen / methanol / 7 h / 55 - 65 °C / 11251.1 - 15001.5 Torr / Autoclave; Inert atmosphere
2: formic acid; dipotassium hydrogenphosphate; palladium diacetate / water / 6 h / 25 - 45 °C / Inert atmosphere
View Scheme
(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one
1038924-70-7

(3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dmap / 20 °C
2: sodium hydroxide / 60 °C
View Scheme
(3R,5S)-5-(hydroxymethyl)-3-methyl-2-pyrrolidone

(3R,5S)-5-(hydroxymethyl)-3-methyl-2-pyrrolidone

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: triphenylphosphine; bromine / dichloromethane / 0 - 20 °C
2.1: magnesium; iodine / tetrahydrofuran / 0 - 60 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
3.1: dmap / 20 °C
4.1: sodium hydroxide / 60 °C
View Scheme
Multi-step reaction with 4 steps
1.1: triethylamine / dichloromethane / 20 °C
2.1: magnesium; iodine / tetrahydrofuran / 0 - 60 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
3.1: dmap / 20 °C
4.1: sodium hydroxide / 60 °C
View Scheme
(3R,5S)-5-(bromomethyl)-3-methyl-2-pyrrolidone

(3R,5S)-5-(bromomethyl)-3-methyl-2-pyrrolidone

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: magnesium; iodine / tetrahydrofuran / 0 - 60 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
2.1: dmap / 20 °C
3.1: sodium hydroxide / 60 °C
View Scheme
(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

2,2,2,-trichloroethoxycarbonyl azide

2,2,2,-trichloroethoxycarbonyl azide

tert-butyl (2,2,2-trichloroethyl) ((2R,4R)-1-([1,1'-biphenyl]-4-yl)pentane-2,4-diyl)dicarbamate

tert-butyl (2,2,2-trichloroethyl) ((2R,4R)-1-([1,1'-biphenyl]-4-yl)pentane-2,4-diyl)dicarbamate

Conditions
ConditionsYield
With dmap; copper diacetate In acetonitrile at 80℃; Schlenk technique; Sealed tube;99%
(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

ethanol
64-17-5

ethanol

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride
149690-12-0

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride

Conditions
ConditionsYield
With thionyl chloride98%
With thionyl chloride at 20 - 50℃;96%
With thionyl chloride at 60℃;96%
(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride
149690-12-0

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride

Conditions
ConditionsYield
With thionyl chloride In ethanol at 60℃; for 1h;96.5%
With thiophosgene In ethanol at 70 - 75℃; for 3h;
With thionyl chloride In ethanol; tert-butyl methyl ether at 60 - 70℃; for 3h;
(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

6-(N,N-dimethylamino)-1-hexanol
1862-07-3

6-(N,N-dimethylamino)-1-hexanol

C26H38N2O2*2ClH

C26H38N2O2*2ClH

Conditions
ConditionsYield
With thionyl chloride In dichloromethane for 1h; Reflux;89.7%
(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

benzyl bromide
100-39-0

benzyl bromide

(2R,4S)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methyl-pentanoic acid benzyl ester
1257266-74-2

(2R,4S)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methyl-pentanoic acid benzyl ester

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 60℃; for 0.5h;88.7%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 2h;
2-(N,N-dimethylamino)ethanol
108-01-0

2-(N,N-dimethylamino)ethanol

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

C22H30N2O2*2ClH

C22H30N2O2*2ClH

Conditions
ConditionsYield
With thionyl chloride In dichloromethane for 1h; Reflux;88.7%
(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

ethanol
64-17-5

ethanol

(2R,4S)-4-amino-5-biphenyl-4-yl-2-methylpentanoic acid ethyl ester
752174-62-2

(2R,4S)-4-amino-5-biphenyl-4-yl-2-methylpentanoic acid ethyl ester

Conditions
ConditionsYield
With thionyl chloride at 78℃; Temperature;88%
With thionyl chloride at 40℃; for 4h;87.8%
With thionyl chloride at 0 - 50℃; for 8h; Reagent/catalyst; Temperature;0.7 g
(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

2-(Diethylamino)ethanol
100-37-8

2-(Diethylamino)ethanol

C24H34N2O2*2ClH

C24H34N2O2*2ClH

Conditions
ConditionsYield
With thionyl chloride In dichloromethane for 1h; Reflux;87.2%
(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

N-(2-Hydroxyethyl)phthalimide
3891-07-4

N-(2-Hydroxyethyl)phthalimide

C33H36N2O6

C33H36N2O6

Conditions
ConditionsYield
Stage #1: (2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid With dmap; dicyclohexyl-carbodiimide In dichloromethane for 0.5h;
Stage #2: N-(2-Hydroxyethyl)phthalimide In dichloromethane for 4h; Reflux;
85.7%
(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

ethanol
64-17-5

ethanol

ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoate
149709-60-4

ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoate

Conditions
ConditionsYield
With thionyl chloride for 10h; Reflux;85%
(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

N-benzyl-2-(ethylamino)ethanol
91339-47-8

N-benzyl-2-(ethylamino)ethanol

C29H36N2O2*2ClH

C29H36N2O2*2ClH

Conditions
ConditionsYield
With thionyl chloride In dichloromethane for 11h; Reflux;83.2%
(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

isopropyl alcohol
67-63-0

isopropyl alcohol

(2R, 4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid isopropyl ester

(2R, 4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid isopropyl ester

Conditions
ConditionsYield
With thionyl chloride at 85℃; for 9h;80%
With thionyl chloride at 0 - 80℃; for 8h;0.75 g
(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

D-lysine

D-lysine

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine
137862-53-4

N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine

C24H28N5O3(1-)*Ca(2+)*C6H14N2O2*C22H23NO5(2-)

C24H28N5O3(1-)*Ca(2+)*C6H14N2O2*C22H23NO5(2-)

Conditions
ConditionsYield
Stage #1: (2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid; D-lysine; N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine With water; sodium hydroxide In acetone at 20℃; for 1h;
Stage #2: With calcium chloride In acetone for 3h;
75.5%
methanol
67-56-1

methanol

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid methyl ester

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid methyl ester

Conditions
ConditionsYield
With thionyl chloride at 40℃; for 4h; Temperature; Concentration;75%
(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

C28H38N6O3

C28H38N6O3

triethylamine
121-44-8

triethylamine

C49H59N7O8(1-)*2C6H16N(1+)

C49H59N7O8(1-)*2C6H16N(1+)

Conditions
ConditionsYield
In tetrahydrofuran for 6h;64.5%
(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

C30H42N6O3

C30H42N6O3

triethylamine
121-44-8

triethylamine

C51H63N7O8(1-)*2C6H16N(1+)

C51H63N7O8(1-)*2C6H16N(1+)

Conditions
ConditionsYield
In tetrahydrofuran for 6h;61.5%
(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

methanesulfonamide
3144-09-0

methanesulfonamide

((1S,3R)-1-biphenyl-4-ylmethyl-4-methanesulfonylamino-3-methyl-4-oxo-butyl)-carbamic acid tert-butyl ester
1257266-71-9

((1S,3R)-1-biphenyl-4-ylmethyl-4-methanesulfonylamino-3-methyl-4-oxo-butyl)-carbamic acid tert-butyl ester

Conditions
ConditionsYield
With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;55%
(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

ethanol
64-17-5

ethanol

(2R,4S)-4-amino-5-biphenyl-4-yl-2-methylpentanoic acid ethyl ester hydrobromide
1038924-98-9

(2R,4S)-4-amino-5-biphenyl-4-yl-2-methylpentanoic acid ethyl ester hydrobromide

Conditions
ConditionsYield
With dibromo sulfoxide at 65℃; for 1.5h;
(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

ethanol
64-17-5

ethanol

(2R,4S)-4-amino-5-biphenyl-4-yl-2-methylpentanoic acid ethyl ester hydrogen sulphate

(2R,4S)-4-amino-5-biphenyl-4-yl-2-methylpentanoic acid ethyl ester hydrogen sulphate

Conditions
ConditionsYield
With sulfuric acid at 65℃;
(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

ethanol
64-17-5

ethanol

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid hydrochloride
1038924-71-8

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; water In ethyl acetate at 130℃; for 1.75h; Product distribution / selectivity;
(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid
1012341-50-2

(2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid

ethyl iodide
75-03-6

ethyl iodide

ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoate
149709-60-4

ethyl (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoate

Conditions
ConditionsYield
Stage #1: (2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid With caesium carbonate In N,N-dimethyl-formamide
Stage #2: ethyl iodide In N,N-dimethyl-formamide at 20℃; Product distribution / selectivity;
With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 16h;
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