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Hangzhou Dingyan Chem Co., Ltd

Analysis Tests Standard Results Appearance A white or almost white powder Complies Identification a.

High purity Various Specifications Baclofen CAS:1134-47-0

Cas:1134-47-0

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Trading Company

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Hefei Zhaobo Technology Co., Ltd.

Baclofen CAS 1134-47-0 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quality control system,a

Baclofen CAS 1134-47-0

Cas:1134-47-0

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

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Shanghai Norky Pharmaceutical Co., LTD.

service we can provide: 1. mixed container, we can mix different items in one container. 2. quality control, before shipment, free sample for test. after shipment, keep sample for 3 years 3. prompt shipment with professional documents 4. packing as y

Baclofen| CAS 1134-47-0| 4-Amino-3-(p-chlorophenyl)butyric acid

Cas:1134-47-0

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Baclofen Manufacturer/High quality/Best price/In stock

Cas:1134-47-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Kono Chem Co.,Ltd

Product Name Baclofen CAS NO. 1134-47-0 Ap

CAS:1134-47-0 Baclofen

Cas:1134-47-0

Min.Order:1 Kilogram

Negotiable

Type:Other

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Baclofen, CAS 1134-47-0

Cas:1134-47-0

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Hefei TNJ chemical industry co.,ltd

Good quality Competitive price On time delivery Our Advantages: Full experience of large numbers containers loading in main Chinese seaports Packing with pallet as buyer's special request Best service after shipment with e-mail

Good quality Baclofen//1134-47-0

Cas:1134-47-0

Min.Order:1 Kilogram

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Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Baclofen

Cas:1134-47-0

Min.Order:1

Negotiable

Type:Other

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Baclofen manufacturer with low price

Cas:1134-47-0

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Baclofen 1134-47-0 ISO Manufacturer

Cas:1134-47-0

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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HANGZHOU CLAKE BIOTECH CO.,LTD

1. ISO 2. IN STOCK 3. FAST REPLY QUALIFED ; EFFICIENCY; RESPONSIBLE Appearance:WHITE POWDER Storage:in cool Package:25kg/drum Application:active pharmaceutical ingredient Transportation:as request Port:any port

Baclofen

Cas:1134-47-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Baclofen

Cas:1134-47-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Baclofen CAS NO: 1134-47-0 Grade:Medical scientific research and export Molecular formula:C10H12ClNO2 Molecular weight:213.6608 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data

Baclofen/cas:1134-47-0/Raw material spot

Cas:1134-47-0

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Baclofen Basic information Product Name: Baclofen Synonyms: -(Aminomethyl)-4-chlorobenzenpropanoicacid;-(p-Chlorophenyl)-aminobutyricacid;ba34647;baclon;beta-(4-chlorophenyl)gaba;beta-(a

1134-47-0

Cas:1134-47-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Baclofen

Cas:1134-47-0

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 1134-47-0 with best quality

Cas:1134-47-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hot Sale 1134-47-0 Baclofen

Cas:1134-47-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by email in time prod

Wholesaler Baclofen 1134-47-0 1134-47-0 Fast Delivery Best price

Cas:1134-47-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Baclofen/ LIDE PHARMA- Factory supply / Best price

Cas:1134-47-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

CAS 1134-47-0 Name Baclofen MW 213.66100 MF C10H12ClNO2 Appearance White to very pale yellow solid Appearance:White powde

Baclofen

Cas:1134-47-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hangzhou Sartort Biopharma Co., Ltd

Appearance:white to very faintly yellow solid Storage:Room temperature Package:25kg/drum Application:Chemicals Transportation:Express/Sea/Air Port:Any port in china

High Purity Baclofen 4-Amino-3-(p-chlorophenyl)butyric acid

Cas:1134-47-0

Min.Order:25 Kilogram

Negotiable

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

Applications Lithium hydride is used as condensation agent, reducing agent, alkylation reagent and desiccant in organic synthesis, and is also a good hydrogen storage material Advantages: Hubei XinRunde Chemical Co., Ltd is a renowned

Hot Sell 99% High Putiry Baclofen CAS 1134-47-0

Cas:1134-47-0

Min.Order:10 Gram

FOB Price: $1500.0 / 2000.0

Type:Other

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Hangzhou Think Chemical Co. Ltd

Baclofen CAS:1134-47-0 Name Baclofen Synonyms beta-(Aminomethyl)-4-chlorobenzenepropanoic acid; Lioresal Molecular Structure Molecular Formula C10H12ClNO2

Baclofen

Cas:1134-47-0

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Baclofen 1134-47-0

Cas:1134-47-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Shanghai Minstar Chemical Co., Ltd

Product Name: Baclofen CAS: 1134-47-0 MF: C10H12ClNO2 MW: 213.66 EINECS: 214-486-9 Mol File: 1134-47-0.mol Baclofen Structure Baclofen Chemical Properties Melting point 208-210°C Boiling point 364.3±32.0 °C(

Baclofen

Cas:1134-47-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Baclofen, CAS: 1134-47-0, Pharmaceutical Intermediates

Cas:1134-47-0

Min.Order:1 Kilogram

FOB Price: $421.0 / 485.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply High-quality Baclofen manufacturer 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in China and expo

High-quality Baclofen manufacturer

Cas:1134-47-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shanghai Terui OP New Material Technology Co., Ltd.

We have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful d

cas 1134-47-0 Baclofen Chinese manufacturer

Cas:1134-47-0

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,

Baclofen CAS NO.: 1134-47-0

Cas:1134-47-0

Min.Order:20 Metric Ton

Negotiable

Type:Trading Company

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Synthetic route

3-(4-chlorophenyl)-4-(1,3-dioxoisoindolin-2-yl)-N-(quinolin-8-yl)butanamide

3-(4-chlorophenyl)-4-(1,3-dioxoisoindolin-2-yl)-N-(quinolin-8-yl)butanamide

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

Conditions
ConditionsYield
With hydrogenchloride In water at 130℃; for 24h; Sealed tube;97%
3-(4-chlorophenyl)-4-((((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)carbonyl)amino)butanoic acid

3-(4-chlorophenyl)-4-((((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)carbonyl)amino)butanoic acid

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

Conditions
ConditionsYield
With sodium L-ascorbate; fluorescein free acid In aq. phosphate buffer for 0.5h; pH=7.4; Irradiation;87%
4-(4-chlorophenyl)pyrrolidin-2-one
22518-27-0

4-(4-chlorophenyl)pyrrolidin-2-one

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

Conditions
ConditionsYield
With hydrogenchloride; water In water for 16h; Reflux;81%
With hydrogenchloride for 2h; Heating;54%
3-(p-chlorophenyl)glutaramic acid
1141-23-7

3-(p-chlorophenyl)glutaramic acid

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

Conditions
ConditionsYield
With sodium sulfamate; sodium hypobromide at -5 - 55℃; for 2.16667h;79.4%
(E)-3-(4-chlorophenyl)-3-cyanoacrylic acid

(E)-3-(4-chlorophenyl)-3-cyanoacrylic acid

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

Conditions
ConditionsYield
With ammonia; hydrogen In water at 25 - 30℃; for 6h;70%
ethyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(4-chlorophenyl)butanoate
927207-26-9

ethyl 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(4-chlorophenyl)butanoate

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

Conditions
ConditionsYield
With hydrogenchloride; hydrazine hydrate In ethanol Heating;58%
Baclofen hydrochloride

Baclofen hydrochloride

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

Conditions
ConditionsYield
With ammonium hydroxide In methanol at 60℃; for 2h; pH=6.9 - 7;41%
ethyl 3-(4-chlorophenyl)-3-hydroxybutanoate
21133-98-2

ethyl 3-(4-chlorophenyl)-3-hydroxybutanoate

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 1.) p-toluenesulfonic acid, 2.) 10percent NaOH / 1.) toluene, reflux, 3 h, 2.) reflux, 2 h
2: 37 percent / 1.) N-bromosuccinimide, 2.) NH3 / 1.) CCl4, reflux, 48 h, 2.) THF, 3 h
3: 16 percent / NH3 / tetrahydrofuran / 3 h
4: 65 percent / 1 M NH4OH / 1 h / 70 °C
5: 59 percent / H2, Raney nickel W-5 / ethanol / 16 h / 3040 Torr / Ambient temperature
6: 54 percent / 6 M HCl / 2 h / Heating
View Scheme
Multi-step reaction with 6 steps
1: 1.) p-toluenesulfonic acid, 2.) 10percent NaOH / 1.) toluene, reflux, 3 h, 2.) reflux, 2 h
2: 37 percent / N-bromosuccinimide / CCl4 / 48 h / Heating
3: 16 percent / NH3 / tetrahydrofuran / 3 h
4: 65 percent / 1 M NH4OH / 1 h / 70 °C
5: 59 percent / H2, Raney nickel W-5 / ethanol / 16 h / 3040 Torr / Ambient temperature
6: 54 percent / 6 M HCl / 2 h / Heating
View Scheme
(E)-3-(4-chlorophenyl)but-2-enoic acid
81187-89-5, 21758-07-6

(E)-3-(4-chlorophenyl)but-2-enoic acid

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 37 percent / 1.) N-bromosuccinimide, 2.) NH3 / 1.) CCl4, reflux, 48 h, 2.) THF, 3 h
2: 16 percent / NH3 / tetrahydrofuran / 3 h
3: 65 percent / 1 M NH4OH / 1 h / 70 °C
4: 59 percent / H2, Raney nickel W-5 / ethanol / 16 h / 3040 Torr / Ambient temperature
5: 54 percent / 6 M HCl / 2 h / Heating
View Scheme
Multi-step reaction with 5 steps
1: 37 percent / N-bromosuccinimide / CCl4 / 48 h / Heating
2: 16 percent / NH3 / tetrahydrofuran / 3 h
3: 65 percent / 1 M NH4OH / 1 h / 70 °C
4: 59 percent / H2, Raney nickel W-5 / ethanol / 16 h / 3040 Torr / Ambient temperature
5: 54 percent / 6 M HCl / 2 h / Heating
View Scheme
para-chloroacetophenone
99-91-2

para-chloroacetophenone

6-<p-tolylimino-methyl>-benzo<1.3>dioxol-5-ylamine

6-<p-tolylimino-methyl>-benzo<1.3>dioxol-5-ylamine

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 240 g / Zn / benzene / Heating
2: 1.) p-toluenesulfonic acid, 2.) 10percent NaOH / 1.) toluene, reflux, 3 h, 2.) reflux, 2 h
3: 37 percent / 1.) N-bromosuccinimide, 2.) NH3 / 1.) CCl4, reflux, 48 h, 2.) THF, 3 h
4: 16 percent / NH3 / tetrahydrofuran / 3 h
5: 65 percent / 1 M NH4OH / 1 h / 70 °C
6: 59 percent / H2, Raney nickel W-5 / ethanol / 16 h / 3040 Torr / Ambient temperature
7: 54 percent / 6 M HCl / 2 h / Heating
View Scheme
Multi-step reaction with 7 steps
1: 240 g / Zn / benzene / Heating
2: 1.) p-toluenesulfonic acid, 2.) 10percent NaOH / 1.) toluene, reflux, 3 h, 2.) reflux, 2 h
3: 37 percent / N-bromosuccinimide / CCl4 / 48 h / Heating
4: 16 percent / NH3 / tetrahydrofuran / 3 h
5: 65 percent / 1 M NH4OH / 1 h / 70 °C
6: 59 percent / H2, Raney nickel W-5 / ethanol / 16 h / 3040 Torr / Ambient temperature
7: 54 percent / 6 M HCl / 2 h / Heating
View Scheme
4-(4-chlorophenyl)-1,5-dihydro-2H-pyrrol-2-one
81187-93-1

4-(4-chlorophenyl)-1,5-dihydro-2H-pyrrol-2-one

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 59 percent / H2, Raney nickel W-5 / ethanol / 16 h / 3040 Torr / Ambient temperature
2: 54 percent / 6 M HCl / 2 h / Heating
View Scheme
(Z)-4-amino-3-(4-chlorophenyl)but-2-enoic acid
81187-91-9

(Z)-4-amino-3-(4-chlorophenyl)but-2-enoic acid

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 65 percent / 1 M NH4OH / 1 h / 70 °C
2: 59 percent / H2, Raney nickel W-5 / ethanol / 16 h / 3040 Torr / Ambient temperature
3: 54 percent / 6 M HCl / 2 h / Heating
View Scheme
(Z)-4-Bromo-3-(4-chloro-phenyl)-but-2-enoic acid
81187-90-8

(Z)-4-Bromo-3-(4-chloro-phenyl)-but-2-enoic acid

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 16 percent / NH3 / tetrahydrofuran / 3 h
2: 65 percent / 1 M NH4OH / 1 h / 70 °C
3: 59 percent / H2, Raney nickel W-5 / ethanol / 16 h / 3040 Torr / Ambient temperature
4: 54 percent / 6 M HCl / 2 h / Heating
View Scheme
ethyl rac β-[(aminomethyl)-4-chlorophenyl]-propancarboxylate

ethyl rac β-[(aminomethyl)-4-chlorophenyl]-propancarboxylate

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

Conditions
ConditionsYield
With hydrogenchloride In water Cooling with ice;
3-chloro-4-(4-chlorophenyl)-5-hydroxyfuran-2(5H)-one

3-chloro-4-(4-chlorophenyl)-5-hydroxyfuran-2(5H)-one

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: acetic acid / chloroform / 1 h / 0 - 20 °C
1.2: 20 °C
2.1: trifluoroacetic acid / 1,2-dichloro-ethane / 2 h / 80 °C
3.1: nickel dichloride; sodium tetrahydroborate / methanol; tetrahydrofuran / 1 h / 0 - 20 °C
4.1: hydrogenchloride; water / water / 16 h / Reflux
View Scheme
3-chloro-4-(4-chlorophenyl)-1-(2,4-dimethoxybenzyl)-1H-pyrrol-2(5H)-one

3-chloro-4-(4-chlorophenyl)-1-(2,4-dimethoxybenzyl)-1H-pyrrol-2(5H)-one

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: trifluoroacetic acid / 1,2-dichloro-ethane / 2 h / 80 °C
2: nickel dichloride; sodium tetrahydroborate / methanol; tetrahydrofuran / 1 h / 0 - 20 °C
3: hydrogenchloride; water / water / 16 h / Reflux
View Scheme
3-chloro-4-(4-chlorophenyl)-1H-pyrrol-2(5H)-one

3-chloro-4-(4-chlorophenyl)-1H-pyrrol-2(5H)-one

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: nickel dichloride; sodium tetrahydroborate / methanol; tetrahydrofuran / 1 h / 0 - 20 °C
2: hydrogenchloride; water / water / 16 h / Reflux
View Scheme
4-Chlorophenylboronic acid
1679-18-1

4-Chlorophenylboronic acid

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: cesium fluoride; tetrabutyl-ammonium chloride; bis-triphenylphosphine-palladium(II) chloride / toluene; water / 18 h / 20 °C / Inert atmosphere
2.1: acetic acid / chloroform / 1 h / 0 - 20 °C
2.2: 20 °C
3.1: trifluoroacetic acid / 1,2-dichloro-ethane / 2 h / 80 °C
4.1: nickel dichloride; sodium tetrahydroborate / methanol; tetrahydrofuran / 1 h / 0 - 20 °C
5.1: hydrogenchloride; water / water / 16 h / Reflux
View Scheme
4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: potassium tert-butylate / toluene; methanol / 0.5 h / 20 °C / 4500.45 Torr / Inert atmosphere
1.2: 0.11 h / 25 °C / 4500.45 Torr / Inert atmosphere
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 50 °C / 6000.6 Torr
3.1: lithium hydroxide; water / toluene / 1 h / 50 °C / 3750.38 Torr
4.1: hydrogen / methanol / 60 °C / 45004.5 Torr
View Scheme
Multi-step reaction with 5 steps
1: diammonium phosphate / water / 5 h / 15 - 20 °C
2: potassium hydroxide / 2 h / 85 - 90 °C
3: urea / 1 h / 130 - 140 °C
4: sodium hydroxide / water / 1.5 h / 65 - 70 °C
5: sodium hypobromide; sodium sulfamate / 2.17 h / -5 - 55 °C
View Scheme
methyl 4-chlorocinnamate
7560-44-3, 20754-21-6, 20754-24-9

methyl 4-chlorocinnamate

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 50 °C / 6000.6 Torr
2: lithium hydroxide; water / toluene / 1 h / 50 °C / 3750.38 Torr
3: hydrogen / methanol / 60 °C / 45004.5 Torr
View Scheme
methyl (+/-)-3-(4-chlorophenyl)-4-nitrobutanoate
101466-69-7

methyl (+/-)-3-(4-chlorophenyl)-4-nitrobutanoate

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: lithium hydroxide; water / toluene / 1 h / 50 °C / 3750.38 Torr
2: hydrogen / methanol / 60 °C / 45004.5 Torr
View Scheme
(+/-)-4-nitro-3-(4-chloro)butanoic acid
159112-23-9

(+/-)-4-nitro-3-(4-chloro)butanoic acid

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

Conditions
ConditionsYield
With hydrogen In methanol at 60℃; under 45004.5 Torr;493 mg
2-(4-chlorophenylmethylene)acetoacetic acid ethyl ester
19411-80-4

2-(4-chlorophenylmethylene)acetoacetic acid ethyl ester

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: potassium hydroxide / 2 h / 85 - 90 °C
2: urea / 1 h / 130 - 140 °C
3: sodium hydroxide / water / 1.5 h / 65 - 70 °C
4: sodium hypobromide; sodium sulfamate / 2.17 h / -5 - 55 °C
View Scheme
3-(4-chlorophenyl)pentane-1,5-dioic acid
35271-74-0

3-(4-chlorophenyl)pentane-1,5-dioic acid

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: urea / 1 h / 130 - 140 °C
2: sodium hydroxide / water / 1.5 h / 65 - 70 °C
3: sodium hypobromide; sodium sulfamate / 2.17 h / -5 - 55 °C
View Scheme
ethanol
64-17-5

ethanol

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

ethyl 4-amino-3-(4-chlorophenyl)butanoate hydrochloride

ethyl 4-amino-3-(4-chlorophenyl)butanoate hydrochloride

Conditions
ConditionsYield
With thionyl chloride at 0 - 80℃; for 5h;99%
With hydrogenchloride at 20℃; for 24h;
4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

butan-1-ol
71-36-3

butan-1-ol

baclofen n-butyl ester hydrochloride

baclofen n-butyl ester hydrochloride

Conditions
ConditionsYield
With hydrogenchloride at 105℃; for 0.5h;98%
With hydrogenchloride at 20℃; for 24h;
methanol
67-56-1

methanol

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

methyl (RS)-4-amino-3-(4-chlorophenyl)butanoate hydrochloride

methyl (RS)-4-amino-3-(4-chlorophenyl)butanoate hydrochloride

Conditions
ConditionsYield
With thionyl chloride for 0.5h; Ambient temperature;98%
With thionyl chloride95%
With hydrogenchloride89%
With hydrogenchloride at 20℃; for 24h;
4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

4-(4-chlorophenyl)pyrrolidin-2-one
22518-27-0

4-(4-chlorophenyl)pyrrolidin-2-one

Conditions
ConditionsYield
With aluminum oxide In toluene for 16h; Heating / reflux;90%
With aluminum oxide In toluene for 5h; Heating;88%
With silica gel In toluene for 6h; Heating;85%
2-chloroethyl isothiocyanate
1943-83-5

2-chloroethyl isothiocyanate

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

3-(4-chlorophenyl)-4-[3-(2-chloroethyl)ureido]butyric acid
213407-00-2

3-(4-chlorophenyl)-4-[3-(2-chloroethyl)ureido]butyric acid

Conditions
ConditionsYield
With sodium hydroxide for 1h; Ambient temperature;89%
4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

2,4-Dinitrofluorobenzene
70-34-8

2,4-Dinitrofluorobenzene

γ-2,4-Dinitrophenylamino-β-(p-chlorophenyl)butyric acid

γ-2,4-Dinitrophenylamino-β-(p-chlorophenyl)butyric acid

Conditions
ConditionsYield
With sodium hydrogencarbonate In ethanol at 60℃; for 0.75h;84%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

4-((tert-butoxycarbonyl)amino)-3-(4-chlorophenyl)butanoic acid
78131-30-3

4-((tert-butoxycarbonyl)amino)-3-(4-chlorophenyl)butanoic acid

Conditions
ConditionsYield
Stage #1: di-tert-butyl dicarbonate; 4-amino-3-(4-chlorophenyl)butanoic acid With sodium hydroxide; water In 1,4-dioxane at 0 - 20℃; for 4h;
Stage #2: With citric acid In 1,4-dioxane; water pH=3;
84%
cis,trans-2,5-dimethoxytetrahydrofuran
696-59-3

cis,trans-2,5-dimethoxytetrahydrofuran

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

3-(4-chlorophenyl)-4-pyrrol-1-ylbutyric acid
187870-25-3

3-(4-chlorophenyl)-4-pyrrol-1-ylbutyric acid

Conditions
ConditionsYield
With acetic acid for 1h; Heating;82%
With acetic acid Clauson-Kaas reaction;
2-oxo-4-phenylbutyric acid
710-11-2

2-oxo-4-phenylbutyric acid

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

3-(4-chlorophenyl)-4-(3-phenylpropanethioamido)butanoic acid

3-(4-chlorophenyl)-4-(3-phenylpropanethioamido)butanoic acid

Conditions
ConditionsYield
With sulfur; 1-dodecylthiol In N,N-dimethyl-formamide at 20℃; for 2h; Sealed tube; chemoselective reaction;76%
4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

phenyl isocyanate
103-71-9

phenyl isocyanate

3-(4-chlorophenyl)-4-(3-phenylureido)butyric acid

3-(4-chlorophenyl)-4-(3-phenylureido)butyric acid

Conditions
ConditionsYield
With sodium hydroxide for 1h; Ambient temperature;75%
4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

ethyl isocyanate
109-90-0

ethyl isocyanate

3-(4-chlorophenyl)-4-(3-ethylureido)butyric acid
213406-99-6

3-(4-chlorophenyl)-4-(3-ethylureido)butyric acid

Conditions
ConditionsYield
With sodium hydroxide Addition;74%
With sodium hydroxide for 1h; Ambient temperature;45%
Propyl isocyanate
110-78-1

Propyl isocyanate

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

3-(-chlorophenyl)-4-(3-propylureido)butyric acid

3-(-chlorophenyl)-4-(3-propylureido)butyric acid

Conditions
ConditionsYield
With sodium hydroxide for 1h; Ambient temperature;63%
2-oxoheptadecanoic acid
73506-86-2

2-oxoheptadecanoic acid

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

3-(4-chlorophenyl)-4-palmitamidobutanoic acid

3-(4-chlorophenyl)-4-palmitamidobutanoic acid

Conditions
ConditionsYield
With tert.-butylhydroperoxide In water; N,N-dimethyl-formamide at 20℃; for 1h; Sealed tube; Darkness; chemoselective reaction;61%
octanol
111-87-5

octanol

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

A

1-Chlorooctane
111-85-3

1-Chlorooctane

B

4-Amino-3-(4-chloro-phenyl)-butyric acid octyl ester; hydrochloride
131403-01-5

4-Amino-3-(4-chloro-phenyl)-butyric acid octyl ester; hydrochloride

Conditions
ConditionsYield
With hydrogenchloride at 130℃;A n/a
B 54%
4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

2,4,6-triphenylpyrylium tetrafluoroborate
448-61-3

2,4,6-triphenylpyrylium tetrafluoroborate

C33H27ClNO2(1+)*BF4(1-)

C33H27ClNO2(1+)*BF4(1-)

Conditions
ConditionsYield
In ethanol at 85 - 90℃; for 4h; Schlenk technique;54%
4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

trifluoroacetic anhydride
407-25-0

trifluoroacetic anhydride

A

4-(4-chlorophenyl)pyrrolidin-2-one
22518-27-0

4-(4-chlorophenyl)pyrrolidin-2-one

B

3-(4-chlorophenyl)-4-(2,2,2-trifluoroacetylamino)-butyric acid
229014-55-5

3-(4-chlorophenyl)-4-(2,2,2-trifluoroacetylamino)-butyric acid

Conditions
ConditionsYield
In diethyl ether at 20℃; for 0.5h; Friedel-Crafts cyclization;A 42%
B 38%
4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

6-bromo-3-methyl-2-phenylquinoline-4-carboxylic acid

6-bromo-3-methyl-2-phenylquinoline-4-carboxylic acid

(+/-)-4-{[(6-bromo-3-methyl-2-phenylquinolin-4-yl)carbonyl]amino}-3-(4-chlorophenyl)butanoic acid

(+/-)-4-{[(6-bromo-3-methyl-2-phenylquinolin-4-yl)carbonyl]amino}-3-(4-chlorophenyl)butanoic acid

Conditions
ConditionsYield
Stage #1: 6-bromo-3-methyl-2-phenylquinoline-4-carboxylic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: 4-amino-3-(4-chlorophenyl)butanoic acid In N,N-dimethyl-formamide at 60℃; for 3h;
41%
4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

Isopropyl isocyanate
1795-48-8

Isopropyl isocyanate

3-(4-chlorophenyl)-4-(3-isopropylureido)butyric acid

3-(4-chlorophenyl)-4-(3-isopropylureido)butyric acid

Conditions
ConditionsYield
With sodium hydroxide for 1h; Ambient temperature;40%
2,5-dioxopyrrolidin-1-yl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl carbonate
1255209-41-6

2,5-dioxopyrrolidin-1-yl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl carbonate

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

3-(4-chlorophenyl)-4-((((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)carbonyl)amino)butanoic acid

3-(4-chlorophenyl)-4-((((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)carbonyl)amino)butanoic acid

Conditions
ConditionsYield
With potassium carbonate In water; N,N-dimethyl-formamide Inert atmosphere;38.4%
4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

3,5-dinitrobenzoic anhydride
40993-10-0

3,5-dinitrobenzoic anhydride

3-(4-chloro-phenyl)-4-(3,5-dinitro-benzoylamino)-butyric acid

3-(4-chloro-phenyl)-4-(3,5-dinitro-benzoylamino)-butyric acid

Conditions
ConditionsYield
With pyridine; dmap In acetonitrile at 20℃; for 0.25h;
propan-1-ol
71-23-8

propan-1-ol

4-amino-3-(4-chlorophenyl)butanoic acid
1134-47-0

4-amino-3-(4-chlorophenyl)butanoic acid

baclofen 1-propyl ester hydrochloride

baclofen 1-propyl ester hydrochloride

Conditions
ConditionsYield
With hydrogenchloride at 20℃; for 24h;
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