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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Etoposide Manufacturer/High quality/Best price/In stock

Cas:33419-42-0

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result appearance White or taupe to yellow crystalline powder Measure up Solubility

High purity Various Specifications Etoposide CAS:33419-42-0

Cas:33419-42-0

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

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Hubei Vanz Pharm Co.,Ltd

Hubei Vanz Pharm Co. Ltd. is located in Wuhan, Hubei province. We are one of the most professional company in pharm/chmecial industry for more than 10 years. We export to many countries and area with very competitive price, high quality, good servi

Etoposide CAS33419-42-0

Cas:33419-42-0

Min.Order:1 Gram

FOB Price: $8.0 / 12.0

Type:Manufacturers

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Etoposide capsules 500mg/vial;1g/vial/2g/vial

Cas:33419-42-0

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Etoposide CAS 33419-42-0 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distributing th

Etoposide CAS 33419-42-0

Cas:33419-42-0

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Etoposide

Cas:33419-42-0

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Etoposide 33419-42-0 ISO Producer

Cas:33419-42-0

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chengdu Lemeitian Pharmaceutical Technology Co,. Ltd

ADVANTAGE: 1. More than 3,000 Chinese medicine reference substances / standard products available from stock, issued on the same day, multiple cities can be delivered the next day 2. The products are provided with COA, HPLC, NMR, quality assurance,

Etoposide

Cas:33419-42-0

Min.Order:10 Metric Ton

Negotiable

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Etoposide

Cas:33419-42-0

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Etoposide

Cas:33419-42-0

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Etoposide CAS:33419-42-0 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability Pro

Etoposide Manufacturer/High quality/Best price/In stock

Cas:33419-42-0

Min.Order:25 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Etoposide / LIDE PHARMA- Factory supply / Best price

Cas:33419-42-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

CAS :33419-42-0 Etoposide Powder

Cas:33419-42-0

Min.Order:1 Kilogram

FOB Price: $32.0 / 65.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

Etoposide 33419-42-0

Cas:33419-42-0

Min.Order:1 Metric Ton

FOB Price: $500.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 33419-42-0 with fast shipping

Cas:33419-42-0

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

1. Superior quality 2.Competitive price 3. Good service 4 Flexible payment Etoposide CAS: 33419-42-0 Appearance:Almost white to white crystalline powder Assay: NLT 99.0% Packing: 1kg/aluminum tin; 25kg/carton barrel.

Etoposide 33419-42-0

Cas:33419-42-0

Min.Order:1 Kilogram

FOB Price: $1.0 / 2.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white powder Storage:Store in sealed containers at cool & dr

HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

High Purity 99.6% Anti-Tumor Etoposide CAS 33419-42-0 Manufacturer and Exporter

Cas:33419-42-0

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem (China) Co.,Ltd is Specia

High quality Etoposide

Cas:33419-42-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:White powder / Refer to COA Storage:Refer to CO

33419-42-0 cas 99% Manufacturer Etoposide

Cas:33419-42-0

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Leader Biochemical Group

About Product Details Items Specifications Test Results Appearance White to white crystalline powde

Manufacturer Supply Etoposide CAS 33419-42-0 for Scientific Research use only

Cas:33419-42-0

Min.Order:1 Gram

FOB Price: $1.0 / 5.0

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Etoposide

Cas:33419-42-0

Min.Order:1 Gram

FOB Price: $45.0 / 55.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Etoposide CAS:33419-42-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Etoposide CAS:33419-42-0

Cas:33419-42-0

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Etoposide

Cas:33419-42-0

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:33419-42-0

Cas:33419-42-0

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: Etoposide Synonyms: 9-((4,6-O-Ethylidene-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one;[5R-[5alpha,5abeta,8aalpha,9beta(R*)]]-9-[(4,6-O-E

Etoposide free sample available best quality

Cas:33419-42-0

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Etoposide

Cas:33419-42-0

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

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Triumph International Development Limilted

Triumph has the complete production of G- KG - MT service chain,we can make the new technology into productivity quickly in the research and development of new products. Main Business Custom Synthesis: Trading(Raw Mater

Etoposide

Cas:33419-42-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Etoposide 33419-42-0

Cas:33419-42-0

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Etoposide

Cas:33419-42-0

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Synthetic route

2''-3''-di-O-benzyletoposide
217475-21-3

2''-3''-di-O-benzyletoposide

etoposide
33419-42-0

etoposide

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In tetrahydrofuran at 20℃; under 2585.81 Torr; for 4h; Catalytic hydrogenation;96.8%
With hydrogen; 5%-palladium/activated carbon In tetrahydrofuran at 20℃; under 2585.81 Torr; for 4h; Product distribution / selectivity; Buchi apparatus;96.8%
With hydrogen; 5%-palladium/activated carbon In acetone at 20℃; under 2250.23 Torr; for 1h; Product distribution / selectivity;93.3%
With hydrogen; Pd/C In tetrahydrofuran; methanol at 20℃; under 2585.81 Torr; for 3.5h; Product distribution / selectivity; Parr-shaker bottle;92.5%
Carbonic acid benzyl ester 4-[(5R,5aR,8aR,9S)-9-((2R,4aR,6R,7R,8S,8aR)-7,8-bis-benzyloxy-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl]-2,6-dimethoxy-phenyl ester
270928-23-9

Carbonic acid benzyl ester 4-[(5R,5aR,8aR,9S)-9-((2R,4aR,6R,7R,8S,8aR)-7,8-bis-benzyloxy-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl]-2,6-dimethoxy-phenyl ester

etoposide
33419-42-0

etoposide

Conditions
ConditionsYield
With hydrogen; trifluoroacetic acid; palladium on activated charcoal In methanol; ethyl acetate under 2585.81 Torr; for 12h; Hydrogenation;85%
4-demethylepipodophyllotoxin-7'-O-β-D-glucopyranoside
23363-35-1

4-demethylepipodophyllotoxin-7'-O-β-D-glucopyranoside

1,1-dimethoxyethane
534-15-6

1,1-dimethoxyethane

etoposide
33419-42-0

etoposide

Conditions
ConditionsYield
With toluene-4-sulfonic acid In nitromethane at 25℃; for 2h;68%
diethyl acetal
105-57-7

diethyl acetal

C57H47ClO18
134659-25-9

C57H47ClO18

etoposide
33419-42-0

etoposide

Conditions
ConditionsYield
With methanol; zinc diacetate; toluene-4-sulfonic acid 1.) sealed tube, 70 deg C, 12 h, 2.) MeCN, 0.5 h; Yield given. Multistep reaction;
2,3-di-O-chloroacetyl-4:6-O-ethylidene-β-D-glucopuranose
92206-84-3

2,3-di-O-chloroacetyl-4:6-O-ethylidene-β-D-glucopuranose

Chloro-acetic acid 4-((5S,5aS,9R)-9-hydroxy-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenyl ester
92206-82-1, 112246-47-6

Chloro-acetic acid 4-((5S,5aS,9R)-9-hydroxy-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenyl ester

A

etoposide
33419-42-0

etoposide

B

(5S,5aS,8aS,9R)-9-((2R,4aR,6R,7R,8R,8aS)-7,8-Dihydroxy-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-5-(4-hydroxy-3,5-dimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one
112246-48-7

(5S,5aS,8aS,9R)-9-((2R,4aR,6R,7R,8R,8aS)-7,8-Dihydroxy-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-5-(4-hydroxy-3,5-dimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one

Conditions
ConditionsYield
With boron trifluoride diethyl etherate; zinc diacetate 1.) CH2Cl2, 2.) reflux, MeOH; Yield given. Multistep reaction. Yields of byproduct given;
Acetic acid 4-[(5R,5aR,8aR,9S)-9-((2R,4aR,6R,7R,8S,8aR)-7,8-diacetoxy-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl]-2,6-dimethoxy-phenyl ester
172138-90-8

Acetic acid 4-[(5R,5aR,8aR,9S)-9-((2R,4aR,6R,7R,8S,8aR)-7,8-diacetoxy-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl]-2,6-dimethoxy-phenyl ester

A

etoposide
33419-42-0

etoposide

B

(5R,6R,7R,8S)-8-((2R,4aR,6R,7R,8R,8aS)-7,8-Dihydroxy-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-5-(4-hydroxy-3,5-dimethoxy-phenyl)-7-hydroxymethyl-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid methyl ester

(5R,6R,7R,8S)-8-((2R,4aR,6R,7R,8R,8aS)-7,8-Dihydroxy-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-5-(4-hydroxy-3,5-dimethoxy-phenyl)-7-hydroxymethyl-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid methyl ester

C

etoposide

etoposide

Conditions
ConditionsYield
With zinc diacetate In methanol for 96h; Heating; Yield given;A n/a
B 1.5 g
C n/a
With zinc diacetate In methanol for 96h; Heating; Yields of byproduct given;A n/a
B 1.5 g
C n/a
With zinc diacetate In methanol for 96h; Heating; Yield given. Yields of byproduct given;A n/a
B 1.5 g
C n/a
4'-demethylepipodophyllotoxin
6559-91-7

4'-demethylepipodophyllotoxin

etoposide
33419-42-0

etoposide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 81.9 percent / BF3*OEt2 / acetonitrile / 5 h / -10 °C
2: 96.8 percent / H2 / Pd/C / tetrahydrofuran / 4 h / 20 °C / 2585.81 Torr
View Scheme
Multi-step reaction with 2 steps
1: BF3*OEt2 / acetonitrile / -10 °C
2: 96.8 percent / H2 / Pd/C / tetrahydrofuran / 4 h / 20 °C / 2585.81 Torr
View Scheme
Multi-step reaction with 3 steps
1: 75 percent / BF3*Et2O / CH2Cl2 / 0.5 h / -20 °C
2: 70 percent / Zn(OAc)2, MeOH / 40 h / Heating
3: 68 percent / TsOH / nitromethane / 2 h / 25 °C
View Scheme
4,6-O-ethylidene-2,3-O-dibenzyl-D-glucose

4,6-O-ethylidene-2,3-O-dibenzyl-D-glucose

etoposide
33419-42-0

etoposide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 81.9 percent / BF3*OEt2 / acetonitrile / 5 h / -10 °C
2: 96.8 percent / H2 / Pd/C / tetrahydrofuran / 4 h / 20 °C / 2585.81 Torr
View Scheme
Multi-step reaction with 2 steps
1: BF3*OEt2 / acetonitrile / -10 °C
2: 96.8 percent / H2 / Pd/C / tetrahydrofuran / 4 h / 20 °C / 2585.81 Torr
View Scheme
4'-demethyl-4'-O-(benzoyloxycarbonyl)epipodophyllotoxin
23363-33-9

4'-demethyl-4'-O-(benzoyloxycarbonyl)epipodophyllotoxin

etoposide
33419-42-0

etoposide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 94 percent / BF3*OEt2 / CH2Cl2 / 1 h / 0 °C
2: m-CPBA / CH2Cl2 / 0.08 h / -78 °C
3: 74 percent / trifluoromethanesulfonic anhydride / CH2Cl2 / 5 h / -78 - -40 °C
4: 85 percent / H2; CF3COOH / Pd/C / ethyl acetate; methanol / 12 h / 2585.81 Torr
View Scheme
Carbonic acid benzyl ester 4-((5R,5aR,8aR,9S)-9-ethylsulfanyl-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenyl ester
270071-30-2

Carbonic acid benzyl ester 4-((5R,5aR,8aR,9S)-9-ethylsulfanyl-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenyl ester

etoposide
33419-42-0

etoposide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: m-CPBA / CH2Cl2 / 0.08 h / -78 °C
2: 74 percent / trifluoromethanesulfonic anhydride / CH2Cl2 / 5 h / -78 - -40 °C
3: 85 percent / H2; CF3COOH / Pd/C / ethyl acetate; methanol / 12 h / 2585.81 Torr
View Scheme
Carbonic acid benzyl ester 4-((5R,5aR,8aR,9S)-9-ethanesulfinyl-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenyl ester

Carbonic acid benzyl ester 4-((5R,5aR,8aR,9S)-9-ethanesulfinyl-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenyl ester

etoposide
33419-42-0

etoposide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 74 percent / trifluoromethanesulfonic anhydride / CH2Cl2 / 5 h / -78 - -40 °C
2: 85 percent / H2; CF3COOH / Pd/C / ethyl acetate; methanol / 12 h / 2585.81 Torr
View Scheme
4'-O-demethyl-4β-bromo-4-desoxypodophyllotoxin
16477-16-0

4'-O-demethyl-4β-bromo-4-desoxypodophyllotoxin

etoposide
33419-42-0

etoposide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 115 g / pyridine / CH2Cl2 / 3 h / 25 - 30 °C
2: water / acetone / a) 45 deg C, 1 h, b) below 10 deg C, 3 h
3: 44 percent / BF3*Et2O / 2 h / 25 - 30 °C
4: Zn(OAc)2*2H2O / methanol / 96 h / Heating
View Scheme
Acetic acid 4-((5R,5aR,8aR,9S)-9-bromo-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenyl ester

Acetic acid 4-((5R,5aR,8aR,9S)-9-bromo-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenyl ester

etoposide
33419-42-0

etoposide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: water / acetone / a) 45 deg C, 1 h, b) below 10 deg C, 3 h
2: 44 percent / BF3*Et2O / 2 h / 25 - 30 °C
3: Zn(OAc)2*2H2O / methanol / 96 h / Heating
View Scheme
Acetic acid 4-((5R,5aR,8aR,9S)-9-hydroxy-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenyl ester

Acetic acid 4-((5R,5aR,8aR,9S)-9-hydroxy-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenyl ester

etoposide
33419-42-0

etoposide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 44 percent / BF3*Et2O / 2 h / 25 - 30 °C
2: Zn(OAc)2*2H2O / methanol / 96 h / Heating
View Scheme
D-Glucose
2280-44-6

D-Glucose

etoposide
33419-42-0

etoposide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: 1.) boron trifluoride etherate, 2.) zinc acetate / 1.) CH2Cl2, 2.) reflux, MeOH
View Scheme
Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 90 percent / pyridine
2: 1.) boron trifluoride etherate, 2.) zinc acetate / 1.) CH2Cl2, 2.) reflux, MeOH
View Scheme
Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) satd. HBr, 2.) BaCO3 / 1.) Et2O, ethylene dichloride, 2.) acetone, H2O
2: 90 percent / pyridine
3: 1.) boron trifluoride etherate, 2.) zinc acetate / 1.) CH2Cl2, 2.) reflux, MeOH
View Scheme
4-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-4'-demethylepipodophyllotoxin
23363-34-0

4-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-4'-demethylepipodophyllotoxin

etoposide
33419-42-0

etoposide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 70 percent / Zn(OAc)2, MeOH / 40 h / Heating
2: 68 percent / TsOH / nitromethane / 2 h / 25 °C
View Scheme
2,3,4,6-tetra-O-acetyl-β-D-glucopyranose
3947-62-4

2,3,4,6-tetra-O-acetyl-β-D-glucopyranose

etoposide
33419-42-0

etoposide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 75 percent / BF3*Et2O / CH2Cl2 / 0.5 h / -20 °C
2: 70 percent / Zn(OAc)2, MeOH / 40 h / Heating
3: 68 percent / TsOH / nitromethane / 2 h / 25 °C
View Scheme
4'-O-chloroacetyl-4'-O-demethyl-4-epipodophyllotoxin
92206-82-1

4'-O-chloroacetyl-4'-O-demethyl-4-epipodophyllotoxin

etoposide
33419-42-0

etoposide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 74 percent / BF3*OEt2 / CH2Cl2 / 0.5 h / -5 °C
2: 1.) Zn(OAc)2, MeOH, 2.) TsOH / 1.) sealed tube, 70 deg C, 12 h, 2.) MeCN, 0.5 h
View Scheme
9-[(4,6-O-ethylidene-Β-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-(1-(5-nitrothien-2-yl)ethoxy)-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtha[2,3-d]-1,3-dioxol-6(5aH)-one

9-[(4,6-O-ethylidene-Β-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-(1-(5-nitrothien-2-yl)ethoxy)-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtha[2,3-d]-1,3-dioxol-6(5aH)-one

etoposide
33419-42-0

etoposide

Conditions
ConditionsYield
G-values;
9-[(4,6-O-ethylidene-Β-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-(5-(4-(5-nitrothien-2-yl)ethoxy)-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtha[2,3-d]-1,3-dioxol-6(5aH)-one

9-[(4,6-O-ethylidene-Β-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-(5-(4-(5-nitrothien-2-yl)ethoxy)-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtha[2,3-d]-1,3-dioxol-6(5aH)-one

etoposide
33419-42-0

etoposide

Conditions
ConditionsYield
G-values;
C33H38O17

C33H38O17

etoposide
33419-42-0

etoposide

Conditions
ConditionsYield
With sodium dihydrogenphosphate; carboxylesterase CES2 at 37℃; pH=7.4; Product distribution / selectivity; Enzymatic reaction;
With sodium dihydrogenphosphate; carboxylesterase CES2 at 37℃; pH=7.4; Product distribution / selectivity; Enzymatic reaction;
4'-(2'',3''-dihydroxypropyl carbonoxy)-etoposide

4'-(2'',3''-dihydroxypropyl carbonoxy)-etoposide

etoposide
33419-42-0

etoposide

Conditions
ConditionsYield
With CES1 In aq. phosphate buffer at 37℃; pH=7.4; Reagent/catalyst; Enzymatic reaction;
C52H55BO18

C52H55BO18

A

7-hydroxy-3-(hydroxymethyl)-2H-chromen-2-one

7-hydroxy-3-(hydroxymethyl)-2H-chromen-2-one

B

etoposide
33419-42-0

etoposide

Conditions
ConditionsYield
With dihydrogen peroxide In methanol; water
C38H48O19

C38H48O19

A

D-glucose
50-99-7

D-glucose

B

etoposide
33419-42-0

etoposide

Conditions
ConditionsYield
With β-glucosidase; water Reagent/catalyst; Enzymatic reaction;
C38H48O19

C38H48O19

A

D-glucose
50-99-7

D-glucose

B

etoposide
33419-42-0

etoposide

Conditions
ConditionsYield
With β-glucosidase; water Reagent/catalyst; Enzymatic reaction;
C38H48O19

C38H48O19

A

D-glucose
50-99-7

D-glucose

B

etoposide
33419-42-0

etoposide

Conditions
ConditionsYield
With β-glucosidase; water Reagent/catalyst; Enzymatic reaction;
C38H48O19

C38H48O19

A

D-glucose
50-99-7

D-glucose

B

etoposide
33419-42-0

etoposide

Conditions
ConditionsYield
With β-glucosidase; water Reagent/catalyst; Enzymatic reaction;
2,2,2-trichloroethylcarbonyl chloride
52999-57-2

2,2,2-trichloroethylcarbonyl chloride

etoposide
33419-42-0

etoposide

4'-O-demethyl-4'-O-(2,2,2-trichloroethoxy)carbonyl-4-O-[4,6-O-ethylidene-2,3-di-O-(2,2,2-trichloroethoxy)carbonyl-β-D-glucopyranosyl]-4-epipodophyllotoxin

4'-O-demethyl-4'-O-(2,2,2-trichloroethoxy)carbonyl-4-O-[4,6-O-ethylidene-2,3-di-O-(2,2,2-trichloroethoxy)carbonyl-β-D-glucopyranosyl]-4-epipodophyllotoxin

Conditions
ConditionsYield
With pyridine In dichloromethane at 20℃; for 5h; Acylation;100%
N-iodoacetyl-N-biotinylhexylenediamine
93285-75-7

N-iodoacetyl-N-biotinylhexylenediamine

etoposide
33419-42-0

etoposide

C47H62N4O16S

C47H62N4O16S

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 0℃; for 9h;100%
N,N-phenylbistrifluoromethane-sulfonimide
37595-74-7

N,N-phenylbistrifluoromethane-sulfonimide

etoposide
33419-42-0

etoposide

Trifluoro-methanesulfonic acid 4-[(5R,5aR,8aR,9S)-9-((2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl]-2,6-dimethoxy-phenyl ester

Trifluoro-methanesulfonic acid 4-[(5R,5aR,8aR,9S)-9-((2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl]-2,6-dimethoxy-phenyl ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 40℃; for 192h;96%
Dibenzyl phosphite
17176-77-1

Dibenzyl phosphite

etoposide
33419-42-0

etoposide

A

Phosphoric acid dibenzyl ester 4-[(5R,5aR,8aR,9S)-9-((2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl]-2,6-dimethoxy-phenyl ester

Phosphoric acid dibenzyl ester 4-[(5R,5aR,8aR,9S)-9-((2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl]-2,6-dimethoxy-phenyl ester

B

C57H58O19P2

C57H58O19P2

C

C57H58O19P2

C57H58O19P2

Conditions
ConditionsYield
With tetrachloromethane; dmap; N-ethyl-N,N-diisopropylamine In acetonitrile at -10℃;A 90%
B n/a
C n/a
chloro-trimethyl-silane
75-77-4

chloro-trimethyl-silane

etoposide
33419-42-0

etoposide

C38H56O13Si3

C38H56O13Si3

Conditions
ConditionsYield
With 1,1,1,3,3,3-hexamethyl-disilazane In pyridine at 75 - 80℃; for 0.166667h;90%
etoposide
33419-42-0

etoposide

picroetoposide
100007-56-5

picroetoposide

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 48h; Isomerization;87%
With borate buffer In 1,4-dioxane; water at 37℃; Rate constant; pH = 10; ionic strength 0.2;
etoposide
33419-42-0

etoposide

Phenoxyacetyl chloride
701-99-5

Phenoxyacetyl chloride

4'-O-demethyl-4'-O-phenoxyacetyl-4-O-[4,6-O-ethylidene-2,3-di-O-phenoxyacetyl-β-D-glucopyranosyl]-4-epipodophyllotoxin

4'-O-demethyl-4'-O-phenoxyacetyl-4-O-[4,6-O-ethylidene-2,3-di-O-phenoxyacetyl-β-D-glucopyranosyl]-4-epipodophyllotoxin

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 4h; Acylation;84%
(3,3-dimethyl-2,4-dioxacyclopentyl)methyl chloroformate
28863-62-9

(3,3-dimethyl-2,4-dioxacyclopentyl)methyl chloroformate

etoposide
33419-42-0

etoposide

4'-(2'',3''-isopropolideneglyceryl carbonoxy)-etoposide
433304-61-1

4'-(2'',3''-isopropolideneglyceryl carbonoxy)-etoposide

Conditions
ConditionsYield
With pyridine In dichloromethane at -70℃; for 6h;83.5%
etoposide
33419-42-0

etoposide

etoposide ortho-quinone

etoposide ortho-quinone

Conditions
ConditionsYield
With ammonium sulfate; sodium periodate In 1,4-dioxane80%
In methanol; water Mechanism; controlled-potential electrolysis; pH 4.6;
In methanol; water controlled-potential electrolysis; pH 4.6;
With sodium periodate In 1,4-dioxane at 10℃; for 110h;
Electrolysis;
etoposide
33419-42-0

etoposide

propargyl bromide
106-96-7

propargyl bromide

(5R,5aR,8aR,9S)-9-(((2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methylhexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy)-5-(3,5-dimethoxy-4-(prop-2-yn-1-yloxy)phenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one

(5R,5aR,8aR,9S)-9-(((2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methylhexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy)-5-(3,5-dimethoxy-4-(prop-2-yn-1-yloxy)phenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one

Conditions
ConditionsYield
Stage #1: etoposide With potassium carbonate In N,N-dimethyl-formamide at 0℃; for 0.0833333h;
Stage #2: propargyl bromide In N,N-dimethyl-formamide at 20℃; for 6h;
79%
C23H24BClO5

C23H24BClO5

etoposide
33419-42-0

etoposide

C52H55BO18

C52H55BO18

Conditions
ConditionsYield
Stage #1: C23H24BClO5 With sodium iodide In acetone at 20℃; for 1h;
Stage #2: etoposide With potassium carbonate In acetonitrile at 20℃; for 6h;
76%
4-acetyl-2-nitrobenzene-1-sulfonyl chloride

4-acetyl-2-nitrobenzene-1-sulfonyl chloride

etoposide
33419-42-0

etoposide

4-acetyl-2-nitrobenzenesulfonyl etoposide

4-acetyl-2-nitrobenzenesulfonyl etoposide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 0.5h;71%
etoposide
33419-42-0

etoposide

4-demethylepipodophyllotoxin-7'-O-β-D-glucopyranoside
23363-35-1

4-demethylepipodophyllotoxin-7'-O-β-D-glucopyranoside

Conditions
ConditionsYield
With acetic acid In water at 68 - 72℃; for 20h;69%
dimethylaminoacetyl chloride
51552-16-0

dimethylaminoacetyl chloride

etoposide
33419-42-0

etoposide

etoposide 4'-dimethylglycine
1220508-24-6

etoposide 4'-dimethylglycine

Conditions
ConditionsYield
With dmap In N,N-dimethyl-formamide at 20℃; for 0.833333h;67%
(E)-3-(4-nitrophenyl)prop-2-en-1-yl bromide
79750-53-1

(E)-3-(4-nitrophenyl)prop-2-en-1-yl bromide

etoposide
33419-42-0

etoposide

C38H39NO15

C38H39NO15

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 60℃; for 30h; Molecular sieve; Inert atmosphere; Darkness;66%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

C32H54O4S2

C32H54O4S2

etoposide
33419-42-0

etoposide

C62H84O18S2

C62H84O18S2

Conditions
ConditionsYield
Stage #1: bis(trichloromethyl) carbonate; C32H54O4S2 With dmap In dichloromethane at 20℃; for 1h; Cooling with ice;
Stage #2: etoposide With dmap In dichloromethane at 20℃; for 12h; Cooling with ice;
65%
etoposide
33419-42-0

etoposide

4-Nitrophenyl chloroformate
7693-46-1

4-Nitrophenyl chloroformate

C36H35NO17

C36H35NO17

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃; for 2.5h; Inert atmosphere;59%
With triethylamine In tetrahydrofuran at 20℃; for 2.5h; Inert atmosphere;59%
etoposide
33419-42-0

etoposide

benzyl [2-(N-chloroformyl-N-methylamino)-4-nitrophenyl-2,3,4-tri-O-(tert-butyldimethylsilyl)-β-D-glucopyranoside]uronate
355010-37-6

benzyl [2-(N-chloroformyl-N-methylamino)-4-nitrophenyl-2,3,4-tri-O-(tert-butyldimethylsilyl)-β-D-glucopyranoside]uronate

benzyl [4-nitrophenyl-2-[(etoposide-4'-O-carbonyl)methyl-amino]-2,3,4-tri-O-(tert-butyldimethylsilyl)-β-D-glucopyranosid]uronate

benzyl [4-nitrophenyl-2-[(etoposide-4'-O-carbonyl)methyl-amino]-2,3,4-tri-O-(tert-butyldimethylsilyl)-β-D-glucopyranosid]uronate

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 20℃; for 16h;57%
C15H17NO5

C15H17NO5

etoposide
33419-42-0

etoposide

C38H44O15

C38H44O15

Conditions
ConditionsYield
With dmap In N,N-dimethyl-formamide for 72h; Reagent/catalyst;54%
etoposide
33419-42-0

etoposide

vitamin E succinate
4345-03-3

vitamin E succinate

C62H84O17
1514918-68-3

C62H84O17

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-(dimethylamino)pyridinium tosylate In 1-methyl-pyrrolidin-2-one; dichloromethane at 20℃; for 2.83333h; Cooling with ice;52%
etoposide
33419-42-0

etoposide

A

(5R,6S,7R,8S)-8-((2R,4aR,6R,7R,8R,8aS)-7,8-Dihydroxy-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-5-(4-hydroxy-3,5-dimethoxy-phenyl)-7-hydroxymethyl-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid hydrazide
124705-74-4

(5R,6S,7R,8S)-8-((2R,4aR,6R,7R,8R,8aS)-7,8-Dihydroxy-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-5-(4-hydroxy-3,5-dimethoxy-phenyl)-7-hydroxymethyl-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid hydrazide

B

(5R,6R,7R,8S)-8-((2R,4aR,6R,7R,8R,8aS)-7,8-Dihydroxy-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-5-(4-hydroxy-3,5-dimethoxy-phenyl)-7-hydroxymethyl-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid hydrazide
124816-28-0

(5R,6R,7R,8S)-8-((2R,4aR,6R,7R,8R,8aS)-7,8-Dihydroxy-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-5-(4-hydroxy-3,5-dimethoxy-phenyl)-7-hydroxymethyl-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid hydrazide

Conditions
ConditionsYield
With hydrazine In methanol; acetic acid for 2h; Heating;A 40%
B 50%
etoposide
33419-42-0

etoposide

C31H48N2O10Si2

C31H48N2O10Si2

C54H75NO20Si2

C54H75NO20Si2

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide49%
5(R,S)-Carboxymethyl-2,2-dimethyl-4-oxo-1,3-dioxolane
114458-03-6

5(R,S)-Carboxymethyl-2,2-dimethyl-4-oxo-1,3-dioxolane

etoposide
33419-42-0

etoposide

C36H40O17
1459706-54-7

C36H40O17

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at -10℃; for 10h; Inert atmosphere;48%
etoposide
33419-42-0

etoposide

A

4′‐O‐demethyldeoxydehydropodophyllotoxin

4′‐O‐demethyldeoxydehydropodophyllotoxin

B

1,2,3,4-tetradehydroetoposide

1,2,3,4-tetradehydroetoposide

C

1,2-didehydroetoposide

1,2-didehydroetoposide

Conditions
ConditionsYield
With sodium perchlorate In methanol for 1.75h; Product distribution; Mechanism; Ambient temperature; electrochemical oxidation, potential 500 or 250 mV, other supporting electrolyte;A 7%
B 47%
C 20%
With tetraethylammonium hydroxide In methanol for 1.75h; Ambient temperature; electrochemical oxidation, potential 250 mV;A 47%
B 11%
C n/a
With sodium perchlorate In methanol for 1.75h; Ambient temperature; electrochemical oxidation, potential 500 mV;A 7%
B 47%
C 20%
With tetraethylammonium hydroxide In methanol for 1.75h; Ambient temperature; electrochemical oxidation, potential 500 mV;A 15%
B 23%
C 41%
etoposide
33419-42-0

etoposide

(2R,4aR,6R,7R,8R,8aS)-6-[(5S,6R,7R,8R)-8-(4-Hydroxy-3,5-dimethoxy-phenyl)-6,7-bis-hydroxymethyl-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxol-5-yloxy]-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxine-7,8-diol
82410-02-4

(2R,4aR,6R,7R,8R,8aS)-6-[(5S,6R,7R,8R)-8-(4-Hydroxy-3,5-dimethoxy-phenyl)-6,7-bis-hydroxymethyl-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxol-5-yloxy]-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxine-7,8-diol

Conditions
ConditionsYield
With lithium aluminium tetrahydride In tetrahydrofuran for 0.5h; Heating;45%
(5-nitrothiophen-2-yl)methanol
20898-85-5

(5-nitrothiophen-2-yl)methanol

etoposide
33419-42-0

etoposide

9-[(4,6-O-ethylidene-Β-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-(5-(4-(5-nitrothien-2-yl)ethoxy)-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtha[2,3-d]-1,3-dioxol-6(5aH)-one

9-[(4,6-O-ethylidene-Β-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-(5-(4-(5-nitrothien-2-yl)ethoxy)-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtha[2,3-d]-1,3-dioxol-6(5aH)-one

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; for 18h;41%
etoposide
33419-42-0

etoposide

2'-chloroetoposide
138261-30-0

2'-chloroetoposide

Conditions
ConditionsYield
With N-chloro-succinimide In N,N-dimethyl-formamide for 3.5h; Ambient temperature;36%
With N-chloro-succinimide In N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere;

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