DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe
Cas:33419-42-0
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inquiryItems Standard Result appearance White or taupe to yellow crystalline powder Measure up Solubility
Cas:33419-42-0
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inquiryHubei Vanz Pharm Co. Ltd. is located in Wuhan, Hubei province. We are one of the most professional company in pharm/chmecial industry for more than 10 years. We export to many countries and area with very competitive price, high quality, good servi
Cas:33419-42-0
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inquiryWe can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C
Cas:33419-42-0
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inquiryEtoposide CAS 33419-42-0 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distributing th
Cas:33419-42-0
Min.Order:10 Kilogram
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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Cas:33419-42-0
Min.Order:1 Gram
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Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:33419-42-0
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Name:Etoposide CAS:33419-42-0 Grade:For chemical industry, scientific research and export Product Quality 12 years of chemical raw materials Mature operation of the industry System stability Data storage Security without vulnerability Pro
Cas:33419-42-0
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:33419-42-0
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
Cas:33419-42-0
Min.Order:1 Kilogram
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inquiryOur company was built in 2009 with an ISO certificate.In the past 6 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
Cas:33419-42-0
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:33419-42-0
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Type:Trading Company
inquiry1. Superior quality 2.Competitive price 3. Good service 4 Flexible payment Etoposide CAS: 33419-42-0 Appearance:Almost white to white crystalline powder Assay: NLT 99.0% Packing: 1kg/aluminum tin; 25kg/carton barrel.
1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white powder Storage:Store in sealed containers at cool & dr
Cas:33419-42-0
Min.Order:100 Gram
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inquiryHanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr
Cas:33419-42-0
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inquiry1,In No Less five years exporting experience. 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Onchem (China) Co.,Ltd is Specia
Cas:33419-42-0
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inquiryPacking: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:White powder / Refer to COA Storage:Refer to CO
Cas:33419-42-0
Min.Order:1 Gram
Negotiable
Type:Trading Company
inquiryAbout Product Details Items Specifications Test Results Appearance White to white crystalline powde
Cas:33419-42-0
Min.Order:1 Gram
FOB Price: $1.0 / 5.0
Type:Lab/Research institutions
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Etoposide CAS:33419-42-0 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,
Cas:33419-42-0
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Product Name: Etoposide Synonyms: 9-((4,6-O-Ethylidene-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one;[5R-[5alpha,5abeta,8aalpha,9beta(R*)]]-9-[(4,6-O-E
Cas:33419-42-0
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-
Cas:33419-42-0
Min.Order:10 Gram
Negotiable
Type:Lab/Research institutions
inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
2''-3''-di-O-benzyletoposide
etoposide
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In tetrahydrofuran at 20℃; under 2585.81 Torr; for 4h; Catalytic hydrogenation; | 96.8% |
With hydrogen; 5%-palladium/activated carbon In tetrahydrofuran at 20℃; under 2585.81 Torr; for 4h; Product distribution / selectivity; Buchi apparatus; | 96.8% |
With hydrogen; 5%-palladium/activated carbon In acetone at 20℃; under 2250.23 Torr; for 1h; Product distribution / selectivity; | 93.3% |
With hydrogen; Pd/C In tetrahydrofuran; methanol at 20℃; under 2585.81 Torr; for 3.5h; Product distribution / selectivity; Parr-shaker bottle; | 92.5% |
Carbonic acid benzyl ester 4-[(5R,5aR,8aR,9S)-9-((2R,4aR,6R,7R,8S,8aR)-7,8-bis-benzyloxy-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl]-2,6-dimethoxy-phenyl ester
etoposide
Conditions | Yield |
---|---|
With hydrogen; trifluoroacetic acid; palladium on activated charcoal In methanol; ethyl acetate under 2585.81 Torr; for 12h; Hydrogenation; | 85% |
4-demethylepipodophyllotoxin-7'-O-β-D-glucopyranoside
1,1-dimethoxyethane
etoposide
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In nitromethane at 25℃; for 2h; | 68% |
Conditions | Yield |
---|---|
With methanol; zinc diacetate; toluene-4-sulfonic acid 1.) sealed tube, 70 deg C, 12 h, 2.) MeCN, 0.5 h; Yield given. Multistep reaction; |
2,3-di-O-chloroacetyl-4:6-O-ethylidene-β-D-glucopuranose
Chloro-acetic acid 4-((5S,5aS,9R)-9-hydroxy-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenyl ester
A
etoposide
B
(5S,5aS,8aS,9R)-9-((2R,4aR,6R,7R,8R,8aS)-7,8-Dihydroxy-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-5-(4-hydroxy-3,5-dimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate; zinc diacetate 1.) CH2Cl2, 2.) reflux, MeOH; Yield given. Multistep reaction. Yields of byproduct given; |
Acetic acid 4-[(5R,5aR,8aR,9S)-9-((2R,4aR,6R,7R,8S,8aR)-7,8-diacetoxy-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl]-2,6-dimethoxy-phenyl ester
A
etoposide
Conditions | Yield |
---|---|
With zinc diacetate In methanol for 96h; Heating; Yield given; | A n/a B 1.5 g C n/a |
With zinc diacetate In methanol for 96h; Heating; Yields of byproduct given; | A n/a B 1.5 g C n/a |
With zinc diacetate In methanol for 96h; Heating; Yield given. Yields of byproduct given; | A n/a B 1.5 g C n/a |
4'-demethylepipodophyllotoxin
etoposide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 81.9 percent / BF3*OEt2 / acetonitrile / 5 h / -10 °C 2: 96.8 percent / H2 / Pd/C / tetrahydrofuran / 4 h / 20 °C / 2585.81 Torr View Scheme | |
Multi-step reaction with 2 steps 1: BF3*OEt2 / acetonitrile / -10 °C 2: 96.8 percent / H2 / Pd/C / tetrahydrofuran / 4 h / 20 °C / 2585.81 Torr View Scheme | |
Multi-step reaction with 3 steps 1: 75 percent / BF3*Et2O / CH2Cl2 / 0.5 h / -20 °C 2: 70 percent / Zn(OAc)2, MeOH / 40 h / Heating 3: 68 percent / TsOH / nitromethane / 2 h / 25 °C View Scheme |
etoposide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 81.9 percent / BF3*OEt2 / acetonitrile / 5 h / -10 °C 2: 96.8 percent / H2 / Pd/C / tetrahydrofuran / 4 h / 20 °C / 2585.81 Torr View Scheme | |
Multi-step reaction with 2 steps 1: BF3*OEt2 / acetonitrile / -10 °C 2: 96.8 percent / H2 / Pd/C / tetrahydrofuran / 4 h / 20 °C / 2585.81 Torr View Scheme |
4'-demethyl-4'-O-(benzoyloxycarbonyl)epipodophyllotoxin
etoposide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 94 percent / BF3*OEt2 / CH2Cl2 / 1 h / 0 °C 2: m-CPBA / CH2Cl2 / 0.08 h / -78 °C 3: 74 percent / trifluoromethanesulfonic anhydride / CH2Cl2 / 5 h / -78 - -40 °C 4: 85 percent / H2; CF3COOH / Pd/C / ethyl acetate; methanol / 12 h / 2585.81 Torr View Scheme |
Carbonic acid benzyl ester 4-((5R,5aR,8aR,9S)-9-ethylsulfanyl-6-oxo-5,5a,6,8,8a,9-hexahydro-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)-2,6-dimethoxy-phenyl ester
etoposide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: m-CPBA / CH2Cl2 / 0.08 h / -78 °C 2: 74 percent / trifluoromethanesulfonic anhydride / CH2Cl2 / 5 h / -78 - -40 °C 3: 85 percent / H2; CF3COOH / Pd/C / ethyl acetate; methanol / 12 h / 2585.81 Torr View Scheme |
etoposide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 74 percent / trifluoromethanesulfonic anhydride / CH2Cl2 / 5 h / -78 - -40 °C 2: 85 percent / H2; CF3COOH / Pd/C / ethyl acetate; methanol / 12 h / 2585.81 Torr View Scheme |
4'-O-demethyl-4β-bromo-4-desoxypodophyllotoxin
etoposide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 115 g / pyridine / CH2Cl2 / 3 h / 25 - 30 °C 2: water / acetone / a) 45 deg C, 1 h, b) below 10 deg C, 3 h 3: 44 percent / BF3*Et2O / 2 h / 25 - 30 °C 4: Zn(OAc)2*2H2O / methanol / 96 h / Heating View Scheme |
etoposide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: water / acetone / a) 45 deg C, 1 h, b) below 10 deg C, 3 h 2: 44 percent / BF3*Et2O / 2 h / 25 - 30 °C 3: Zn(OAc)2*2H2O / methanol / 96 h / Heating View Scheme |
etoposide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 44 percent / BF3*Et2O / 2 h / 25 - 30 °C 2: Zn(OAc)2*2H2O / methanol / 96 h / Heating View Scheme |
D-Glucose
etoposide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 2: 1.) boron trifluoride etherate, 2.) zinc acetate / 1.) CH2Cl2, 2.) reflux, MeOH View Scheme |
(+/-)-4'-O-demethyl-1-epipodophyllotoxin
etoposide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 90 percent / pyridine 2: 1.) boron trifluoride etherate, 2.) zinc acetate / 1.) CH2Cl2, 2.) reflux, MeOH View Scheme |
etoposide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) satd. HBr, 2.) BaCO3 / 1.) Et2O, ethylene dichloride, 2.) acetone, H2O 2: 90 percent / pyridine 3: 1.) boron trifluoride etherate, 2.) zinc acetate / 1.) CH2Cl2, 2.) reflux, MeOH View Scheme |
4-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-4'-demethylepipodophyllotoxin
etoposide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 70 percent / Zn(OAc)2, MeOH / 40 h / Heating 2: 68 percent / TsOH / nitromethane / 2 h / 25 °C View Scheme |
2,3,4,6-tetra-O-acetyl-β-D-glucopyranose
etoposide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 75 percent / BF3*Et2O / CH2Cl2 / 0.5 h / -20 °C 2: 70 percent / Zn(OAc)2, MeOH / 40 h / Heating 3: 68 percent / TsOH / nitromethane / 2 h / 25 °C View Scheme |
4'-O-chloroacetyl-4'-O-demethyl-4-epipodophyllotoxin
etoposide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 74 percent / BF3*OEt2 / CH2Cl2 / 0.5 h / -5 °C 2: 1.) Zn(OAc)2, MeOH, 2.) TsOH / 1.) sealed tube, 70 deg C, 12 h, 2.) MeCN, 0.5 h View Scheme |
etoposide
Conditions | Yield |
---|---|
G-values; |
etoposide
Conditions | Yield |
---|---|
G-values; |
etoposide
Conditions | Yield |
---|---|
With sodium dihydrogenphosphate; carboxylesterase CES2 at 37℃; pH=7.4; Product distribution / selectivity; Enzymatic reaction; | |
With sodium dihydrogenphosphate; carboxylesterase CES2 at 37℃; pH=7.4; Product distribution / selectivity; Enzymatic reaction; |
etoposide
Conditions | Yield |
---|---|
With CES1 In aq. phosphate buffer at 37℃; pH=7.4; Reagent/catalyst; Enzymatic reaction; |
Conditions | Yield |
---|---|
With dihydrogen peroxide In methanol; water |
Conditions | Yield |
---|---|
With β-glucosidase; water Reagent/catalyst; Enzymatic reaction; |
Conditions | Yield |
---|---|
With β-glucosidase; water Reagent/catalyst; Enzymatic reaction; |
Conditions | Yield |
---|---|
With β-glucosidase; water Reagent/catalyst; Enzymatic reaction; |
Conditions | Yield |
---|---|
With β-glucosidase; water Reagent/catalyst; Enzymatic reaction; |
2,2,2-trichloroethylcarbonyl chloride
etoposide
Conditions | Yield |
---|---|
With pyridine In dichloromethane at 20℃; for 5h; Acylation; | 100% |
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 0℃; for 9h; | 100% |
N,N-phenylbistrifluoromethane-sulfonimide
etoposide
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In acetonitrile at 40℃; for 192h; | 96% |
Conditions | Yield |
---|---|
With tetrachloromethane; dmap; N-ethyl-N,N-diisopropylamine In acetonitrile at -10℃; | A 90% B n/a C n/a |
Conditions | Yield |
---|---|
With 1,1,1,3,3,3-hexamethyl-disilazane In pyridine at 75 - 80℃; for 0.166667h; | 90% |
etoposide
picroetoposide
Conditions | Yield |
---|---|
With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 48h; Isomerization; | 87% |
With borate buffer In 1,4-dioxane; water at 37℃; Rate constant; pH = 10; ionic strength 0.2; |
etoposide
Phenoxyacetyl chloride
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 4h; Acylation; | 84% |
(3,3-dimethyl-2,4-dioxacyclopentyl)methyl chloroformate
etoposide
4'-(2'',3''-isopropolideneglyceryl carbonoxy)-etoposide
Conditions | Yield |
---|---|
With pyridine In dichloromethane at -70℃; for 6h; | 83.5% |
etoposide
Conditions | Yield |
---|---|
With ammonium sulfate; sodium periodate In 1,4-dioxane | 80% |
In methanol; water Mechanism; controlled-potential electrolysis; pH 4.6; | |
In methanol; water controlled-potential electrolysis; pH 4.6; | |
With sodium periodate In 1,4-dioxane at 10℃; for 110h; | |
Electrolysis; |
etoposide
propargyl bromide
Conditions | Yield |
---|---|
Stage #1: etoposide With potassium carbonate In N,N-dimethyl-formamide at 0℃; for 0.0833333h; Stage #2: propargyl bromide In N,N-dimethyl-formamide at 20℃; for 6h; | 79% |
Conditions | Yield |
---|---|
Stage #1: C23H24BClO5 With sodium iodide In acetone at 20℃; for 1h; Stage #2: etoposide With potassium carbonate In acetonitrile at 20℃; for 6h; | 76% |
etoposide
Conditions | Yield |
---|---|
With triethylamine In dichloromethane at 20℃; for 0.5h; | 71% |
etoposide
4-demethylepipodophyllotoxin-7'-O-β-D-glucopyranoside
Conditions | Yield |
---|---|
With acetic acid In water at 68 - 72℃; for 20h; | 69% |
dimethylaminoacetyl chloride
etoposide
etoposide 4'-dimethylglycine
Conditions | Yield |
---|---|
With dmap In N,N-dimethyl-formamide at 20℃; for 0.833333h; | 67% |
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 60℃; for 30h; Molecular sieve; Inert atmosphere; Darkness; | 66% |
Conditions | Yield |
---|---|
Stage #1: bis(trichloromethyl) carbonate; C32H54O4S2 With dmap In dichloromethane at 20℃; for 1h; Cooling with ice; Stage #2: etoposide With dmap In dichloromethane at 20℃; for 12h; Cooling with ice; | 65% |
Conditions | Yield |
---|---|
With triethylamine In tetrahydrofuran at 20℃; for 2.5h; Inert atmosphere; | 59% |
With triethylamine In tetrahydrofuran at 20℃; for 2.5h; Inert atmosphere; | 59% |
etoposide
benzyl [2-(N-chloroformyl-N-methylamino)-4-nitrophenyl-2,3,4-tri-O-(tert-butyldimethylsilyl)-β-D-glucopyranoside]uronate
Conditions | Yield |
---|---|
With dmap; triethylamine In dichloromethane at 20℃; for 16h; | 57% |
Conditions | Yield |
---|---|
With dmap In N,N-dimethyl-formamide for 72h; Reagent/catalyst; | 54% |
Conditions | Yield |
---|---|
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-(dimethylamino)pyridinium tosylate In 1-methyl-pyrrolidin-2-one; dichloromethane at 20℃; for 2.83333h; Cooling with ice; | 52% |
etoposide
A
(5R,6S,7R,8S)-8-((2R,4aR,6R,7R,8R,8aS)-7,8-Dihydroxy-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-5-(4-hydroxy-3,5-dimethoxy-phenyl)-7-hydroxymethyl-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid hydrazide
B
(5R,6R,7R,8S)-8-((2R,4aR,6R,7R,8R,8aS)-7,8-Dihydroxy-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-5-(4-hydroxy-3,5-dimethoxy-phenyl)-7-hydroxymethyl-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid hydrazide
Conditions | Yield |
---|---|
With hydrazine In methanol; acetic acid for 2h; Heating; | A 40% B 50% |
Conditions | Yield |
---|---|
With caesium carbonate In N,N-dimethyl-formamide | 49% |
5(R,S)-Carboxymethyl-2,2-dimethyl-4-oxo-1,3-dioxolane
etoposide
C36H40O17
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at -10℃; for 10h; Inert atmosphere; | 48% |
etoposide
Conditions | Yield |
---|---|
With sodium perchlorate In methanol for 1.75h; Product distribution; Mechanism; Ambient temperature; electrochemical oxidation, potential 500 or 250 mV, other supporting electrolyte; | A 7% B 47% C 20% |
With tetraethylammonium hydroxide In methanol for 1.75h; Ambient temperature; electrochemical oxidation, potential 250 mV; | A 47% B 11% C n/a |
With sodium perchlorate In methanol for 1.75h; Ambient temperature; electrochemical oxidation, potential 500 mV; | A 7% B 47% C 20% |
With tetraethylammonium hydroxide In methanol for 1.75h; Ambient temperature; electrochemical oxidation, potential 500 mV; | A 15% B 23% C 41% |
etoposide
(2R,4aR,6R,7R,8R,8aS)-6-[(5S,6R,7R,8R)-8-(4-Hydroxy-3,5-dimethoxy-phenyl)-6,7-bis-hydroxymethyl-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxol-5-yloxy]-2-methyl-hexahydro-pyrano[3,2-d][1,3]dioxine-7,8-diol
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran for 0.5h; Heating; | 45% |
(5-nitrothiophen-2-yl)methanol
etoposide
Conditions | Yield |
---|---|
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; for 18h; | 41% |
etoposide
2'-chloroetoposide
Conditions | Yield |
---|---|
With N-chloro-succinimide In N,N-dimethyl-formamide for 3.5h; Ambient temperature; | 36% |
With N-chloro-succinimide In N,N-dimethyl-formamide at 0 - 20℃; Inert atmosphere; |
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