Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
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inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
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inquiryCompany Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments
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inquiryHangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det
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inquiryJ&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia
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inquiryZibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
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inquiry4-chloro-5-hydroxymethyl-1H-imidazol-1-yl) methyl] - [1,1'-Biphenyl] -2-carbonitrile; 4-chloro-5-hydroxyMethyliMidzole-1-ylMethyl) -biphenyl-2-carbonitrile; Des [2'- (1H-tetrazol-5-yl)] 2-Cyanolosartan; -chl
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inquiryGMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,
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inquiryProduct name: 4'-[(2-Butyl-4-Chloro-5-Hydroxymethyl-1H-Imidazol-1-yl)methyl]-1,1'-biphenyl-2-Carbonitrile CAS No.: 114772-55-3 Molecule Formula:C22H22ClN3O Molecule Weight:379.88 Purity: 99.0% Package: 25kg/drum Description:Whit
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inquiryWe Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O
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inquiryZhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed
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inquiryHigh quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use
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inquiryhigh purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier
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inquiryJinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands
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inquiryhigh quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea
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inquiryTAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp
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inquiryhigh purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:Beijing or Guangzhou
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inquiryKONING PHARMCHEM CO., LTD. has committed itself to a strategy of providing a unique service for companies involved in the manufacture of pharmaceuticals, healthcare products, food, cosmetics and other fine chemicals. Our products including but not li
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inquiryfactory?direct?sale Application:healing drugs
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inquiryAppearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China
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inquiryXiamen Luyunjia Trading Co.,Ltd Package:1kg/bag; 3641kg/drum, or as customer's request. Application:Xiamen Luyunjia Trading Co.,Ltd Transportation:DHL, EMS, FedEx, TNT, AIR, SEA Port:Beijing,Shanghai,Guangzhou ,China main port
4'-[(2-Butyl-4-chloro-5-hydroxymethyl-1H-imidazol-1-yl)methyl]-1,1'-biphenyl-2-carbonitrile cas 114772-55-3Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:
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inquiryfactory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin
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inquiry2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)methyl]imidazole-5-carboxaldehyde
2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole
Conditions | Yield |
---|---|
With methanol; sodium tetrahydroborate In toluene at 25 - 45℃; for 4h; Product distribution / selectivity; | 100% |
With sodium tetrahydroborate In methanol at 0℃; for 0.5h; | 83.7% |
With sodium tetrahydroborate In methanol at -12 - -10℃; Inert atmosphere; Large scale; | 71.2% |
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole
Conditions | Yield |
---|---|
Stage #1: 2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde; 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile With potassium carbonate In 1-methyl-pyrrolidin-2-one at 70 - 75℃; Stage #2: With sodium tetrahydroborate In 1-methyl-pyrrolidin-2-one at 30℃; Stage #3: With water In 1-methyl-pyrrolidin-2-one; isopropyl alcohol at 75 - 80℃; for 1.5h; | 88% |
With tetrabutylammomium bromide; sodium hydroxide In water; toluene at 20℃; | |
With tetrabutylammomium bromide; water; sodium hydroxide In toluene at 20℃; |
2-n-Butyl-4-chloro-1-(4-bromobenzyl)-1H-imidazole-5-methanol
2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; palladium diacetate; tris-(o-tolyl)phosphine In ethanol; water for 18h; Product distribution / selectivity; Heating / reflux; | 84% |
With N-ethyl-N,N-diisopropylamine; palladium diacetate; triphenylphosphine In ethanol; water for 18h; Product distribution / selectivity; Heating / reflux; | |
Stage #1: triisopropyl phosphite; triphenylphosphine; palladium dichloride In tetrahydrofuran at 25℃; Stage #2: potassium (2-cyanophenyl)trifluoroborate; 2-n-Butyl-4-chloro-1-(4-bromobenzyl)-1H-imidazole-5-methanol With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; ethanol; water at 25℃; for 18h; Product distribution / selectivity; Heating / reflux; | |
Stage #1: palladium diacetate; tris-(o-tolyl)phosphine In tetrahydrofuran at 25 - 60℃; for 0.5h; Stage #2: potassium (2-cyanophenyl)trifluoroborate; 2-n-Butyl-4-chloro-1-(4-bromobenzyl)-1H-imidazole-5-methanol With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; ethanol; water at 25℃; for 18h; Product distribution / selectivity; Heating / reflux; |
2-n-butyl-4-chloro-5-hydroxymethylimidazole
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole
Conditions | Yield |
---|---|
Stage #1: 2-n-butyl-4-chloro-5-hydroxymethylimidazole With sodium methylate In N,N-dimethyl-formamide at 25℃; for 0.5h; Stage #2: 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile In N,N-dimethyl-formamide at 20℃; for 24h; | 40% |
With sodium methylate 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h; Multistep reaction; |
methyl pentanimidate
2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: NaOH / H2O; methanol; toluene 1.2: 55 percent / POCl3 / toluene / 2 h / 100 °C 2.1: 90 percent / NaBH4 / methanol / 2 h / 20 °C 3.1: NaOMe / dimethylformamide / 0.5 h / 25 °C 3.2: 40 percent / dimethylformamide / 24 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: sodium methylate / methanol / 2 h / 0 °C / Green chemistry 2: trichlorophosphate / toluene / 2 h / 60 - 100 °C / Green chemistry 3: potassium carbonate / N,N-dimethyl-formamide / 6 h / 40 °C / Green chemistry 4: sodium tetrahydroborate / methanol / 1.17 h / 20 - 40 °C / Green chemistry View Scheme |
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde
2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: 90 percent / NaBH4 / methanol / 2 h / 20 °C 2.1: NaOMe / dimethylformamide / 0.5 h / 25 °C 2.2: 40 percent / dimethylformamide / 24 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 40 °C / Green chemistry 2: sodium tetrahydroborate / methanol / 1.17 h / 20 - 40 °C / Green chemistry View Scheme | |
Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl-formamide / 12 h / -10 °C / Inert atmosphere 2: sodium tetrahydroborate / methanol / 0.5 h / 0 °C View Scheme | |
Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl acetamide / 5 h / 20 °C 2: sodium tetrahydroborate / methanol; N,N-dimethyl acetamide / 1 h / 5 - 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: sodium carbonate; tetraethylammonium bromide / toluene / 90 - 95 °C 2: sodium tetrahydroborate; sodium hydroxide / water / 20 - 85 °C View Scheme |
2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline
2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: tetrahydrofuran / 2 h / 20 °C 2: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C 3: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating 4: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h View Scheme |
2-Cyano-4'-methylbiphenyl
2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating 2: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h View Scheme | |
Multi-step reaction with 3 steps 1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; 2,2'-azobis(isobutyronitrile) / dichloromethane / 24 h / 40 - 42 °C / Reflux; Large scale 2: potassium carbonate / N,N-dimethyl acetamide / 4 h / -12 - -8 °C / Inert atmosphere; Large scale 3: sodium tetrahydroborate / methanol / -12 - -10 °C / Inert atmosphere; Large scale View Scheme | |
Multi-step reaction with 3 steps 1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / 80 °C / Green chemistry 2: potassium carbonate / N,N-dimethyl-formamide / 6 h / 40 °C / Green chemistry 3: sodium tetrahydroborate / methanol / 1.17 h / 20 - 40 °C / Green chemistry View Scheme |
N-(2-hydroxy-1,1-dimethyl)-2-methoxybenzamide
2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: thionyl chloride / 1 h / 25 °C 2: tetrahydrofuran / 2 h / 20 °C 3: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C 4: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating 5: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h View Scheme |
4,4-dimethyl-2-(4'-methyl-biphenyl-2-yl)-4,5-dihydrooxazole
2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C 2: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating 3: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h View Scheme |
2-Methoxybenzoic acid
2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: 95 percent / thionyl chloride / 18 h / 20 °C 2: CH2Cl2 / 2 h / 20 °C 3: thionyl chloride / 1 h / 25 °C 4: tetrahydrofuran / 2 h / 20 °C 5: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C 6: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating 7: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h View Scheme |
2-Methoxybenzoyl chloride
2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: CH2Cl2 / 2 h / 20 °C 2: thionyl chloride / 1 h / 25 °C 3: tetrahydrofuran / 2 h / 20 °C 4: 96 percent / pyridine, phosphorus oxychloride / 3 h / 100 °C 5: N-bromosuccinimide, dibenzoyl peroxide / CCl4 / 3 h / Heating 6: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h View Scheme |
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole
Conditions | Yield |
---|---|
With sodium methylate In N-methyl-acetamide; hexane; ethyl acetate; N,N-dimethyl-formamide | |
With sodium methylate In N-methyl-acetamide; hexane; ethyl acetate; N,N-dimethyl-formamide | |
With sodium methylate In N-methyl-acetamide; hexane; ethyl acetate; N,N-dimethyl-formamide |
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile
2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole
Conditions | Yield |
---|---|
In hexane; ethyl acetate | |
Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl acetamide / 4 h / -12 - -8 °C / Inert atmosphere; Large scale 2: sodium tetrahydroborate / methanol / -12 - -10 °C / Inert atmosphere; Large scale View Scheme | |
Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 40 °C / Green chemistry 2: sodium tetrahydroborate / methanol / 1.17 h / 20 - 40 °C / Green chemistry View Scheme | |
Multi-step reaction with 2 steps 1: potassium carbonate / N,N-dimethyl-formamide / 12 h / -10 °C / Inert atmosphere 2: sodium tetrahydroborate / methanol / 0.5 h / 0 °C View Scheme | |
Multi-step reaction with 2 steps 1: sodium carbonate; tetraethylammonium bromide / toluene / 90 - 95 °C 2: sodium tetrahydroborate; sodium hydroxide / water / 20 - 85 °C View Scheme |
pentanonitrile
2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: acetyl chloride / 2 h / 0 °C / 760.05 Torr / Green chemistry 2: sodium methylate / methanol / 2 h / 0 °C / Green chemistry 3: trichlorophosphate / toluene / 2 h / 60 - 100 °C / Green chemistry 4: potassium carbonate / N,N-dimethyl-formamide / 6 h / 40 °C / Green chemistry 5: sodium tetrahydroborate / methanol / 1.17 h / 20 - 40 °C / Green chemistry View Scheme |
(pentanimidoylamino)acetic acid
2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: trichlorophosphate / toluene / 2 h / 60 - 100 °C / Green chemistry 2: potassium carbonate / N,N-dimethyl-formamide / 6 h / 40 °C / Green chemistry 3: sodium tetrahydroborate / methanol / 1.17 h / 20 - 40 °C / Green chemistry View Scheme |
2-Chlorobenzonitrile
2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: manganese(ll) chloride; chloro-trimethyl-silane / tetrahydrofuran / -5 - 0 °C / Inert atmosphere; Green chemistry 1.2: 9 h / -5 - 25 °C / Inert atmosphere; Green chemistry 2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / 80 °C / Green chemistry 3.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 40 °C / Green chemistry 4.1: sodium tetrahydroborate / methanol / 1.17 h / 20 - 40 °C / Green chemistry View Scheme |
4-tolylmagnesium chloride
2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1.1: manganese(ll) chloride; chloro-trimethyl-silane / tetrahydrofuran / -5 - 0 °C / Inert atmosphere; Green chemistry 1.2: 9 h / -5 - 25 °C / Inert atmosphere; Green chemistry 2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / 80 °C / Green chemistry 3.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 40 °C / Green chemistry 4.1: sodium tetrahydroborate / methanol / 1.17 h / 20 - 40 °C / Green chemistry View Scheme |
2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole
lorsartan
Conditions | Yield |
---|---|
With sodium azide In 1-methyl-pyrrolidin-2-one | 99% |
With sodium azide In toluene at 20℃; | 95% |
With sodium azide; zinc trifluoromethanesulfonate In water at 100℃; for 6h; Solvent; Temperature; Time; Green chemistry; | 91% |
trimethyltin azide
2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole
Conditions | Yield |
---|---|
99% |
2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole
chloromethyl methyl ether
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 3.5h; | 72.2% |
2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole
EXP 8821
Conditions | Yield |
---|---|
With sodium hydroxide In ethanol for 100h; Heating; | 68% |
trityl chloride
2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole
2-n-butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-methanol
Conditions | Yield |
---|---|
Yield given. Multistep reaction; |
azidotrimethyltin
2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole
Conditions | Yield |
---|---|
In toluene | |
In toluene |
2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole
2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole
Conditions | Yield |
---|---|
Stage #1: 2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole With azido tributyltin (IV) In toluene for 96h; Heating / reflux; Stage #2: With potassium hydroxide In water; toluene Stage #3: In water pH=3; Acidic aqueous solution; | |
Multi-step reaction with 2 steps 1: sodium azide / toluene; 1-methyl-pyrrolidin-2-one / 35 h / 98 - 102 °C / Large scale 2: hydrogenchloride / dichloromethane; water / 4 h / 2 - 5 °C / pH 4 - 4.3 / Large scale View Scheme |
2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole
cozaar
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: C6H16N6O3Zn / butan-1-ol / 100 - 120 °C / Reflux 1.2: 2 h 1.3: pH 3 - 4 2.1: potassium hydroxide / isopropyl alcohol 2.2: 3 h / 20 - 50 °C View Scheme | |
Multi-step reaction with 3 steps 1: sodium azide / toluene; 1-methyl-pyrrolidin-2-one / 35 h / 98 - 102 °C / Large scale 2: hydrogenchloride / dichloromethane; water / 4 h / 2 - 5 °C / pH 4 - 4.3 / Large scale 3: potassium hydroxide / methanol / 0.5 h / 40 - 45 °C / Large scale View Scheme |
triethylamine hydrochloride
2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole
Conditions | Yield |
---|---|
With sodium azide In 1-methyl-pyrrolidin-2-one; toluene at 98 - 102℃; for 35h; Large scale; |
2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium azide / toluene; 1-methyl-pyrrolidin-2-one / 35 h / 98 - 102 °C / Large scale 2: hydrogenchloride / dichloromethane; water / 4 h / 2 - 5 °C / pH 4 - 4.3 / Large scale 3: sulfuryl dichloride / dichloromethane / 1 h / -10 °C View Scheme |
2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium azide / toluene; 1-methyl-pyrrolidin-2-one / 35 h / 98 - 102 °C / Large scale 2: hydrogenchloride / dichloromethane; water / 4 h / 2 - 5 °C / pH 4 - 4.3 / Large scale 3: sulfuryl dichloride / dichloromethane / 1 h / -10 °C 4: sodium azide / N,N-dimethyl-formamide / 1 h / 25 - 30 °C View Scheme |
2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3.5 h / 20 °C 2: potassium carbonate; hydroxylamine hydrochloride / ethanol / 24 h / 90 °C View Scheme |
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