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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Abacavir Manufacturer/High quality/Best price/In stock

Cas:136470-78-5

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

Abacavir manufacturer/supplier

Cas:136470-78-5

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White Crystalline Powder Storage:Refrigerator Package:1kg/foi

High quality Abacavir CAS 136470-78-5 with reasonable price

Cas:136470-78-5

Min.Order:100 Gram

FOB Price: $5.0

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Abacavir

Cas:136470-78-5

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Abacavir 136470-78-5 GMP Manufacturer

Cas:136470-78-5

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm

Abacavir Manufacturer/High quality/Best price/In stock CAS NO.136470-78-5

Cas:136470-78-5

Min.Order:1 Metric Ton

FOB Price: $1.0 / 3.0

Type:Trading Company

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

high quality Abacavir

Cas:136470-78-5

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Wuhan Circle Star Chem-medical Technology co.,Ltd.

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualified

Abacavir

Cas:136470-78-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Abacavir Manufacturer/High quality/Best price/In stock CAS NO:136470-78-5

Cas:136470-78-5

Min.Order:1 Gram

FOB Price: $1.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 136470-78-5 with competitive price

Cas:136470-78-5

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Wentao Chemical Product Co., Ltd.

We are leading fine chemicals supplier in China with ISO certificate, Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED

AbacavirCAS NO.: 136470-78-5

Cas:136470-78-5

Min.Order:1 Gram

FOB Price: $2.0

Type:Lab/Research institutions

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Abacavir 136470-78-5

Cas:136470-78-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Anti-AIDS, Abacavir CAS:136470-78-5

Cas:136470-78-5

Min.Order:1 Kilogram

FOB Price: $342.0 / 358.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Abacavir CAS:136470-78-5 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Abacavir CAS:136470-78-5

Cas:136470-78-5

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Abacavir Powder USP Standard

Cas:136470-78-5

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Changchun Artel lmport and Export trade company

Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,MoneyGram Package 10g,20g,50g,100g,500g,1KGS,

Abacavir CAS NO.136470-78-5

Cas:136470-78-5

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Hebei Mojin Biotechnology Co.,Ltd

Product quality: Our company have high quality product , and also the product we have good manufacture . First of all, this product is of fine quality. Every finish should be checked by quality inspection system.And every one should be also tried

Supply 99% Abacavir CAS 136470-78-5

Cas:136470-78-5

Min.Order:1 Kilogram

FOB Price: $20.0 / 30.0

Type:Trading Company

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Abacavir

Cas:136470-78-5

Min.Order:1 Kilogram

FOB Price: $10.0 / 100.0

Type:Lab/Research institutions

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Triumph International Development Limilted

Appearance:off-white to white solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:By Sea/Air/Courier Port:Qingdao

Abacavir 136470-78-5

Cas:136470-78-5

Min.Order:1 Kilogram

FOB Price: $16.0 / 20.0

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Abacavir

Cas:136470-78-5

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Abacavir Manufacturer/High quality/Best price/In stock CAS NO.136470-78-5

Cas:136470-78-5

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Abacavir 136470-78-5

Cas:136470-78-5

Min.Order:5 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Abacavir

Cas:136470-78-5

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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NewCan Biotech Limited

NewCan Biotech Limited was established in 2021 and is primarily engaged in the research, development, production, and sales of sugars, nucleosides, nucleotides, phosphorylated monomers, as well as next-generation antiviral and antitumor drug intermed

Abacavirhydrochloride

Cas:136470-78-5

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shanghai Hope Chem Co., Ltd

1. Product advantages: exquisite appearance and unique functions. 2. Product Advantages: Our products are the best,fast speed ,in large stock 3. High-quality products and thoughtful service are your greatest satisfaction. 4. The product

Abacavir

Cas:136470-78-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Abacavir

Cas:136470-78-5

Min.Order:0

Negotiable

Type:Lab/Research institutions

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DB BIOTECH CO., LTD

Q1: Are you a manufacturer?Answer: Yes, we are factory founded on 2002. Q2: How to contact with us?Click "contact supplier" And then send us message the product you interest in, you will get reply within 12 hours. Q3:Which kind of payment terms do yo

High quality Abacavir powder with factory price

Cas:136470-78-5

Min.Order:0

Negotiable

Type:Trading Company

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality Abacavir

Cas:136470-78-5

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hangzhou Lingrui Chemical Co.,Ltd.

AbacavirAppearance:White power Storage:2-8 ℃ or Others Package:according to customers' requirements Application:Pharmaceutical intermediates Transportation:By air(EMS or EUB or FedEx or TNT ect...) or by sea(FOB or CIF or CNF ect...)or according to y

Abacavir

Cas:136470-78-5

Min.Order:1 Gram

Negotiable

Type:Other

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

Abacavir Manufacturer/High quality/Best price/In stock CAS NO.136470-78-5

Cas:136470-78-5

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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Synthetic route

(1S,4R)-4-[2-amino-6-chloro-9H-purin-9-yl]-2-cyclopentene-1-methanol
136522-33-3

(1S,4R)-4-[2-amino-6-chloro-9H-purin-9-yl]-2-cyclopentene-1-methanol

Cyclopropylamine
765-30-0

Cyclopropylamine

abacavir
136470-78-5

abacavir

Conditions
ConditionsYield
In ethanol at 70℃;98%
In ethanol Heating;72%
Stage #1: (1S,4R)-4-[2-amino-6-chloro-9H-purin-9-yl]-2-cyclopentene-1-methanol; Cyclopropylamine In butan-1-ol at 40 - 70℃; for 5h;
Stage #2: With sodium hydrogencarbonate In butan-1-ol at 20 - 25℃; for 1h; Product distribution / selectivity;
In butan-1-ol at 45 - 90℃; for 2h; Product distribution / selectivity;
With sodium hydrogencarbonate In ethanol; chloroform0.43 g (80%)
Cyclopropylamine
765-30-0

Cyclopropylamine

(1S,cis)-4-(2-amino-6-chloro-9-H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride
172015-79-1

(1S,cis)-4-(2-amino-6-chloro-9-H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride

abacavir
136470-78-5

abacavir

Conditions
ConditionsYield
In methanol at 70℃; for 12h; Substitution;90%
Stage #1: (1S,cis)-4-(2-amino-6-chloro-9-H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride With triethylamine In water
Stage #2: Cyclopropylamine In water at 70 - 75℃; Concentration; Solvent; Temperature;
90%
In isopropyl alcohol at 90 - 95℃; for 12h; sealed reactor;
In ethanol at 25 - 78℃; for 6h;
With sodium carbonate In ethanol at 70 - 80℃;25 g
(-)-N-{6-(cyclopropylamino)-9-[(1R,4S)-4-(hydroxymethyl)cyclopent-2-enyl]-9H-purin-2-yl}isobutyramide
136470-88-7

(-)-N-{6-(cyclopropylamino)-9-[(1R,4S)-4-(hydroxymethyl)cyclopent-2-enyl]-9H-purin-2-yl}isobutyramide

abacavir
136470-78-5

abacavir

Conditions
ConditionsYield
Stage #1: (-)-N-{6-(cyclopropylamino)-9-[(1R,4S)-4-(hydroxymethyl)cyclopent-2-enyl]-9H-purin-2-yl}isobutyramide With isopropyl alcohol; sodium hydroxide for 1h; Reflux;
Stage #2: With hydrogenchloride In water; isopropyl alcohol at 20 - 25℃; pH=7.0 - 7.5; Product distribution / selectivity;
90%
With sodium hydroxide; water; isopropyl alcohol for 1h; Heating / reflux;77%
With sodium hydroxide; water; isopropyl alcohol for 1h; Product distribution / selectivity; Heating / reflux;43%
pyrographite
7440-44-0

pyrographite

Cyclopropylamine
765-30-0

Cyclopropylamine

(1S,cis)-4-(2-amino-6-chloro-9-H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride
172015-79-1

(1S,cis)-4-(2-amino-6-chloro-9-H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride

abacavir
136470-78-5

abacavir

Conditions
ConditionsYield
With sodium hydroxide In acetone90%
6-cyclopropylamine-9-((1R,4S)-4-((triisopropylsilyloxy)methyl)cyclopent-2-enyl)-9H-purin-2-amine
1067882-78-3

6-cyclopropylamine-9-((1R,4S)-4-((triisopropylsilyloxy)methyl)cyclopent-2-enyl)-9H-purin-2-amine

abacavir
136470-78-5

abacavir

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride; water In tetrahydrofuran at 20℃; for 1h; Inert atmosphere;89%
{(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol sulphate

{(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol sulphate

abacavir
136470-78-5

abacavir

Conditions
ConditionsYield
With sodium hydroxide In water; ethyl acetate at 25 - 45℃; pH=6 - 6.1;78%
((1S,4R)-4-(6-(cyclopropylamino)-2-((4-methoxybenzyl)amino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol
1360538-03-9

((1S,4R)-4-(6-(cyclopropylamino)-2-((4-methoxybenzyl)amino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol

abacavir
136470-78-5

abacavir

Conditions
ConditionsYield
With trifluoroacetic acid In chloroform at 50℃; for 72h; Inert atmosphere;73%
N6-cyclopropyl-N2-(4-methoxybenzyl)-9-((1R,4S)-4-(((triisopropylsilyl)oxy)methyl)cyclopent-2-en-1-yl)-9H-purine-2,6-diamine

N6-cyclopropyl-N2-(4-methoxybenzyl)-9-((1R,4S)-4-(((triisopropylsilyl)oxy)methyl)cyclopent-2-en-1-yl)-9H-purine-2,6-diamine

abacavir
136470-78-5

abacavir

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane at 60℃; for 60h; Schlenk technique;70%
((1S,4R)-4-(2-chloro-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol
1108600-46-9

((1S,4R)-4-(2-chloro-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol

abacavir
136470-78-5

abacavir

Conditions
ConditionsYield
With ammonium hydroxide; copper(l) iodide In ethanol at 150℃; for 40h; Schlenk technique; Sealed tube;63%
Stage #1: ((1S,4R)-4-(2-chloro-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol With hydrazine In methanol; water at 50℃;
Stage #2: With acetic acid; sodium nitrite In water at 0℃; for 1h;
Stage #3: With tin(ll) chloride In ethanol for 2h; Product distribution / selectivity; Heating / reflux;
Stage #1: ((1S,4R)-4-(2-chloro-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol With hydrazine In methanol at 50℃;
Stage #2: With acetic acid; sodium nitrite In water at 0℃; for 1h;
Stage #3: With ammonia; triphenylphosphine In 1,4-dioxane; water for 5h; Product distribution / selectivity; Heating / reflux;
Multi-step reaction with 2 steps
1: dimethyl sulfoxide / 150 °C
2: trifluoroacetic acid / chloroform / 72 h / 50 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: hydrazine hydrate / methanol / 50 °C
2: acetic acid; sodium nitrite / water / 1 h / Cooling with ice
3: stannous chloride dihydrate / ethanol / 2 h / Reflux
View Scheme
Cyclopropylamine
765-30-0

Cyclopropylamine

(1R,4S)-1-[(2-amino-6-chloro-5-formamido-4-pyrimidinyl)amino]-4-(hydroxymethyl)-2-cyclopentene
171887-04-0

(1R,4S)-1-[(2-amino-6-chloro-5-formamido-4-pyrimidinyl)amino]-4-(hydroxymethyl)-2-cyclopentene

A

(1S, 4R)-(4-(2,5-diamino-6-chloro-4-pyrimidinyl)amino)-2-cyclopenten-1-methanol
141271-12-7

(1S, 4R)-(4-(2,5-diamino-6-chloro-4-pyrimidinyl)amino)-2-cyclopenten-1-methanol

B

abacavir
136470-78-5

abacavir

Conditions
ConditionsYield
In butan-1-ol at 130℃; for 21h; Substitution; hydrolysis;A 16%
B 60%
2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

Cyclopropylamine
765-30-0

Cyclopropylamine

cis-3-benzoyloxy-4-(hydroxymethyl)cyclopentene
268737-86-6

cis-3-benzoyloxy-4-(hydroxymethyl)cyclopentene

abacavir
136470-78-5

abacavir

Conditions
ConditionsYield
Stage #1: 2-Amino-6-chloropurin; cis-3-benzoyloxy-4-(hydroxymethyl)cyclopentene With 1,2,2,6,6-pentamethylpiperidine; tris(dibenzylideneacetone)dipalladium (0); triphenylphosphine In tetrahydrofuran; dimethyl sulfoxide at 45℃; for 16h; Solid phase reaction; addition; elimination;
Stage #2: Cyclopropylamine With N-ethyl-N,N-diisopropylamine In butan-1-ol at 80℃; for 4h; Solid phase reaction; amination; Further stages.;
60%
(+/-)-cis-N-[4-chloro-5-formamido-6-[[4-(hydroxymethyl)-2-cyclopentene-1-yl]amino]-2-pyrimidinyl]acetamide

(+/-)-cis-N-[4-chloro-5-formamido-6-[[4-(hydroxymethyl)-2-cyclopentene-1-yl]amino]-2-pyrimidinyl]acetamide

ethanesulfonic acid
594-45-6

ethanesulfonic acid

orthoformic acid triethyl ester
122-51-0

orthoformic acid triethyl ester

Cyclopropylamine
765-30-0

Cyclopropylamine

abacavir
136470-78-5

abacavir

Conditions
ConditionsYield
In hydrogenchloride; methanol; N,N-dimethyl-formamide19%
((1S,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methyl acetate
178456-36-5

((1S,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methyl acetate

abacavir
136470-78-5

abacavir

Conditions
ConditionsYield
With sodium hydroxide; water Yield given;
With sodium hydroxide at 20℃;0.027 g
With sodium hydroxide
(1R,5R)-5-hydroxymethyl-2-cyclopenten-1-ol
143395-28-2

(1R,5R)-5-hydroxymethyl-2-cyclopenten-1-ol

abacavir
136470-78-5

abacavir

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 90 percent / Et3N; DMAP / CH2Cl2 / 0 °C
2: 62 percent / NaH; Pd(PPh3)4 / dimethylsulfoxide; tetrahydrofuran / 45 °C
3: aq. NaOH
View Scheme
Multi-step reaction with 4 steps
1: 90 percent / Et3N; DMAP / CH2Cl2 / 0 °C
2: 0.298 g / NaH; Pd(PPh3)4 / dimethylsulfoxide; tetrahydrofuran / 45 °C
3: ethanol / 5 h / Heating
4: aq. NaOH
View Scheme
Multi-step reaction with 4 steps
1.1: Et3N
2.1: Et3N; 4-DMAP
3.1: aq. HF / acetonitrile
4.1: Pd2(dba)3; PPh3; 1,2,2,6,6-pentamethylpiperidine (pempidine) / tetrahydrofuran; dimethylsulfoxide / 16 h / 45 °C
4.2: 60 percent / EtN(i-Pr)2 / butan-1-ol / 4 h / 80 °C
View Scheme
2-amino-6-(cyclopropylamino)purine
120503-69-7

2-amino-6-(cyclopropylamino)purine

abacavir
136470-78-5

abacavir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 62 percent / NaH; Pd(PPh3)4 / dimethylsulfoxide; tetrahydrofuran / 45 °C
2: aq. NaOH
View Scheme
2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

abacavir
136470-78-5

abacavir

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: dimethylsulfoxide / 16 h / 55 °C
2: 62 percent / NaH; Pd(PPh3)4 / dimethylsulfoxide; tetrahydrofuran / 45 °C
3: aq. NaOH
View Scheme
9-[cis-(1'R,4'S)-4'-acetoxymethyl-2'-cyclopenten-1'-yl]-9H-2-amino-6-chloropurine
162992-44-1

9-[cis-(1'R,4'S)-4'-acetoxymethyl-2'-cyclopenten-1'-yl]-9H-2-amino-6-chloropurine

abacavir
136470-78-5

abacavir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ethanol / 5 h / Heating
2: aq. NaOH
View Scheme
Multi-step reaction with 2 steps
1: ethanol
2: NaOH, H2O
View Scheme
(1R,2R)-2-acetoxy-1-(acetoxymethyl)-3-cyclopentene
178456-34-3

(1R,2R)-2-acetoxy-1-(acetoxymethyl)-3-cyclopentene

abacavir
136470-78-5

abacavir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 62 percent / NaH; Pd(PPh3)4 / dimethylsulfoxide; tetrahydrofuran / 45 °C
2: aq. NaOH
View Scheme
Multi-step reaction with 3 steps
1: 0.298 g / NaH; Pd(PPh3)4 / dimethylsulfoxide; tetrahydrofuran / 45 °C
2: ethanol / 5 h / Heating
3: aq. NaOH
View Scheme
Multi-step reaction with 2 steps
1: 62 percent / NaH, Pd(PPh3)4 / tetrahydrofuran; dimethylsulfoxide
2: NaOH, H2O
View Scheme
Multi-step reaction with 3 steps
1: 65 percent / NaH, Pd(PPh3)4 / tetrahydrofuran; dimethylsulfoxide
2: ethanol
3: NaOH, H2O
View Scheme
[3(1R,2R),4S]-4-benzyl-3-(2-hydroxycyclopent-3-enecarbonyl)oxazolidin-2-one
178327-18-9

[3(1R,2R),4S]-4-benzyl-3-(2-hydroxycyclopent-3-enecarbonyl)oxazolidin-2-one

abacavir
136470-78-5

abacavir

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 78 percent / LiBH4 / tetrahydrofuran; methanol / 1 h / 0 °C
2: 90 percent / Et3N; DMAP / CH2Cl2 / 0 °C
3: 62 percent / NaH; Pd(PPh3)4 / dimethylsulfoxide; tetrahydrofuran / 45 °C
4: aq. NaOH
View Scheme
Multi-step reaction with 5 steps
1: 78 percent / LiBH4 / tetrahydrofuran; methanol / 1 h / 0 °C
2: 90 percent / Et3N; DMAP / CH2Cl2 / 0 °C
3: 0.298 g / NaH; Pd(PPh3)4 / dimethylsulfoxide; tetrahydrofuran / 45 °C
4: ethanol / 5 h / Heating
5: aq. NaOH
View Scheme
Multi-step reaction with 4 steps
1: 78 percent / LiBH4 / tetrahydrofuran; methanol
2: 90 percent / Et3N, DMAP / CH2Cl2
3: 62 percent / NaH, Pd(PPh3)4 / tetrahydrofuran; dimethylsulfoxide
4: NaOH, H2O
View Scheme
Multi-step reaction with 5 steps
1: 78 percent / LiBH4 / tetrahydrofuran; methanol
2: 90 percent / Et3N, DMAP / CH2Cl2
3: 65 percent / NaH, Pd(PPh3)4 / tetrahydrofuran; dimethylsulfoxide
4: ethanol
5: NaOH, H2O
View Scheme
[3(2S,4R),4S]-3-(2-allyl-3-hydroxypent-4-enoyl)-4-benzyloxazolidin-2-one
178327-17-8

[3(2S,4R),4S]-3-(2-allyl-3-hydroxypent-4-enoyl)-4-benzyloxazolidin-2-one

abacavir
136470-78-5

abacavir

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 97 percent / (Cy3P)2Cl2Ru=CHPh / CH2Cl2 / 0.5 h / 25 °C
2: 78 percent / LiBH4 / tetrahydrofuran; methanol / 1 h / 0 °C
3: 90 percent / Et3N; DMAP / CH2Cl2 / 0 °C
4: 62 percent / NaH; Pd(PPh3)4 / dimethylsulfoxide; tetrahydrofuran / 45 °C
5: aq. NaOH
View Scheme
Multi-step reaction with 6 steps
1: 97 percent / (Cy3P)2Cl2Ru=CHPh / CH2Cl2 / 0.5 h / 25 °C
2: 78 percent / LiBH4 / tetrahydrofuran; methanol / 1 h / 0 °C
3: 90 percent / Et3N; DMAP / CH2Cl2 / 0 °C
4: 0.298 g / NaH; Pd(PPh3)4 / dimethylsulfoxide; tetrahydrofuran / 45 °C
5: ethanol / 5 h / Heating
6: aq. NaOH
View Scheme
Multi-step reaction with 5 steps
1: 97 percent / Grubbs catalyst / CH2Cl2
2: 78 percent / LiBH4 / tetrahydrofuran; methanol
3: 90 percent / Et3N, DMAP / CH2Cl2
4: 62 percent / NaH, Pd(PPh3)4 / tetrahydrofuran; dimethylsulfoxide
5: NaOH, H2O
View Scheme
Multi-step reaction with 6 steps
1: 97 percent / Grubbs catalyst / CH2Cl2
2: 78 percent / LiBH4 / tetrahydrofuran; methanol
3: 90 percent / Et3N, DMAP / CH2Cl2
4: 65 percent / NaH, Pd(PPh3)4 / tetrahydrofuran; dimethylsulfoxide
5: ethanol
6: NaOH, H2O
View Scheme
[4S,2R,3R]-(4-benzyl-2-thioxooxazolidin-3-yl)(2-hydroxycyclopent-3-enyl)methanone
268737-90-2

[4S,2R,3R]-(4-benzyl-2-thioxooxazolidin-3-yl)(2-hydroxycyclopent-3-enyl)methanone

abacavir
136470-78-5

abacavir

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 85 percent / LiBH4 / tetrahydrofuran; methanol
2: 90 percent / Et3N; DMAP / CH2Cl2 / 0 °C
3: 62 percent / NaH; Pd(PPh3)4 / dimethylsulfoxide; tetrahydrofuran / 45 °C
4: aq. NaOH
View Scheme
Multi-step reaction with 5 steps
1: 85 percent / LiBH4 / tetrahydrofuran; methanol
2: 90 percent / Et3N; DMAP / CH2Cl2 / 0 °C
3: 0.298 g / NaH; Pd(PPh3)4 / dimethylsulfoxide; tetrahydrofuran / 45 °C
4: ethanol / 5 h / Heating
5: aq. NaOH
View Scheme
Multi-step reaction with 5 steps
1.1: 78 percent / LiBH4 / methanol
2.1: Et3N
3.1: Et3N; 4-DMAP
4.1: aq. HF / acetonitrile
5.1: Pd2(dba)3; PPh3; 1,2,2,6,6-pentamethylpiperidine (pempidine) / tetrahydrofuran; dimethylsulfoxide / 16 h / 45 °C
5.2: 60 percent / EtN(i-Pr)2 / butan-1-ol / 4 h / 80 °C
View Scheme
(E)-(2R,3R)-2-Allyl-hex-4-ene-1,3-diol
318488-34-5

(E)-(2R,3R)-2-Allyl-hex-4-ene-1,3-diol

abacavir
136470-78-5

abacavir

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: Et3N / CH2Cl2
2: (Cy3P)2Cl2Ru=CHPh / CH2Cl2 / 25 °C
3: 62 percent / NaH; Pd(PPh3)4 / dimethylsulfoxide; tetrahydrofuran / 45 °C
4: aq. NaOH
View Scheme
Multi-step reaction with 5 steps
1: Et3N / CH2Cl2
2: (Cy3P)2Cl2Ru=CHPh / CH2Cl2 / 25 °C
3: 0.298 g / NaH; Pd(PPh3)4 / dimethylsulfoxide; tetrahydrofuran / 45 °C
4: ethanol / 5 h / Heating
5: aq. NaOH
View Scheme
Acetic acid (1R,2R)-2-acetoxymethyl-1-((E)-propenyl)-pent-4-enyl ester

Acetic acid (1R,2R)-2-acetoxymethyl-1-((E)-propenyl)-pent-4-enyl ester

abacavir
136470-78-5

abacavir

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: (Cy3P)2Cl2Ru=CHPh / CH2Cl2 / 25 °C
2: 62 percent / NaH; Pd(PPh3)4 / dimethylsulfoxide; tetrahydrofuran / 45 °C
3: aq. NaOH
View Scheme
Multi-step reaction with 4 steps
1: (Cy3P)2Cl2Ru=CHPh / CH2Cl2 / 25 °C
2: 0.298 g / NaH; Pd(PPh3)4 / dimethylsulfoxide; tetrahydrofuran / 45 °C
3: ethanol / 5 h / Heating
4: aq. NaOH
View Scheme
(E)-(2S,3R)-2-Allyl-1-((S)-4-benzyl-2-thioxo-oxazolidin-3-yl)-3-hydroxy-hex-4-en-1-one
318488-32-3

(E)-(2S,3R)-2-Allyl-1-((S)-4-benzyl-2-thioxo-oxazolidin-3-yl)-3-hydroxy-hex-4-en-1-one

abacavir
136470-78-5

abacavir

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 77 percent / NaBH4 / tetrahydrofuran; H2O
2: Et3N / CH2Cl2
3: (Cy3P)2Cl2Ru=CHPh / CH2Cl2 / 25 °C
4: 62 percent / NaH; Pd(PPh3)4 / dimethylsulfoxide; tetrahydrofuran / 45 °C
5: aq. NaOH
View Scheme
Multi-step reaction with 6 steps
1: 77 percent / NaBH4 / tetrahydrofuran; H2O
2: Et3N / CH2Cl2
3: (Cy3P)2Cl2Ru=CHPh / CH2Cl2 / 25 °C
4: 0.298 g / NaH; Pd(PPh3)4 / dimethylsulfoxide; tetrahydrofuran / 45 °C
5: ethanol / 5 h / Heating
6: aq. NaOH
View Scheme
(E)-(2S,3R)-2-Allyl-1-((R)-4-benzyl-2-thioxo-oxazolidin-3-yl)-3-hydroxy-hex-4-en-1-one
318488-35-6

(E)-(2S,3R)-2-Allyl-1-((R)-4-benzyl-2-thioxo-oxazolidin-3-yl)-3-hydroxy-hex-4-en-1-one

abacavir
136470-78-5

abacavir

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 74 percent / (Cy3P)2Cl2Ru=CHPh / CH2Cl2 / 1 h / 40 °C
2: 85 percent / LiBH4 / tetrahydrofuran; methanol
3: 90 percent / Et3N; DMAP / CH2Cl2 / 0 °C
4: 62 percent / NaH; Pd(PPh3)4 / dimethylsulfoxide; tetrahydrofuran / 45 °C
5: aq. NaOH
View Scheme
Multi-step reaction with 6 steps
1: 74 percent / (Cy3P)2Cl2Ru=CHPh / CH2Cl2 / 1 h / 40 °C
2: 85 percent / LiBH4 / tetrahydrofuran; methanol
3: 90 percent / Et3N; DMAP / CH2Cl2 / 0 °C
4: 0.298 g / NaH; Pd(PPh3)4 / dimethylsulfoxide; tetrahydrofuran / 45 °C
5: ethanol / 5 h / Heating
6: aq. NaOH
View Scheme
(1R,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-cyclopent-2-enol
268737-91-3

(1R,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-cyclopent-2-enol

abacavir
136470-78-5

abacavir

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: Et3N; 4-DMAP
2.1: aq. HF / acetonitrile
3.1: Pd2(dba)3; PPh3; 1,2,2,6,6-pentamethylpiperidine (pempidine) / tetrahydrofuran; dimethylsulfoxide / 16 h / 45 °C
3.2: 60 percent / EtN(i-Pr)2 / butan-1-ol / 4 h / 80 °C
View Scheme
Benzoic acid (1R,5R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-cyclopent-2-enyl ester
268737-92-4

Benzoic acid (1R,5R)-5-(tert-butyl-dimethyl-silanyloxymethyl)-cyclopent-2-enyl ester

abacavir
136470-78-5

abacavir

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: aq. HF / acetonitrile
2.1: Pd2(dba)3; PPh3; 1,2,2,6,6-pentamethylpiperidine (pempidine) / tetrahydrofuran; dimethylsulfoxide / 16 h / 45 °C
2.2: 60 percent / EtN(i-Pr)2 / butan-1-ol / 4 h / 80 °C
View Scheme
(2S,3R)-2-Allyl-1-((R)-4-benzyl-2-thioxo-oxazolidin-3-yl)-3-hydroxy-pent-4-en-1-one
268737-89-9

(2S,3R)-2-Allyl-1-((R)-4-benzyl-2-thioxo-oxazolidin-3-yl)-3-hydroxy-pent-4-en-1-one

abacavir
136470-78-5

abacavir

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: 97 percent / catalytic ring-closing metathesis (RCM)
2.1: 78 percent / LiBH4 / methanol
3.1: Et3N
4.1: Et3N; 4-DMAP
5.1: aq. HF / acetonitrile
6.1: Pd2(dba)3; PPh3; 1,2,2,6,6-pentamethylpiperidine (pempidine) / tetrahydrofuran; dimethylsulfoxide / 16 h / 45 °C
6.2: 60 percent / EtN(i-Pr)2 / butan-1-ol / 4 h / 80 °C
View Scheme
(-)-2-azabicyclo[2.2.1]hept-5-en-3-one
79200-56-9

(-)-2-azabicyclo[2.2.1]hept-5-en-3-one

abacavir
136470-78-5

abacavir

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.264 g / tetrahydrofuran; H2O / 18 h / 20 - 60 °C
2: 90.5 percent / LiAlH4 / tetrahydrofuran / 19.5 h / 0 °C / Heating
3: 83 percent / Et3N / ethanol / 7 h / Heating
4: 60 percent / butan-1-ol / 21 h / 130 °C
View Scheme
Multi-step reaction with 5 steps
1: 1.264 g / tetrahydrofuran; H2O / 18 h / 20 - 60 °C
2: 90.5 percent / LiAlH4 / tetrahydrofuran / 19.5 h / 0 °C / Heating
3: 83 percent / Et3N / ethanol / 7 h / Heating
4: 92 percent / triethylorthoformate; HCl / H2O / 4 h
5: 90 percent / methanol / 12 h / 70 °C
View Scheme
abacavir
136470-78-5

abacavir

(1R,cis)-3-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-1-cyclopentane-1-methanol

(1R,cis)-3-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-1-cyclopentane-1-methanol

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethanol under 2585.74 Torr; for 1.5h; Catalytic hydrogenation;98%
ethyl acetate
141-78-6

ethyl acetate

abacavir
136470-78-5

abacavir

((1S,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methyl acetate
178456-36-5

((1S,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methyl acetate

Conditions
ConditionsYield
With heterogeneous zinc/imidazole catalyst for 6.5h; Inert atmosphere; Schlenk technique; Reflux; chemoselective reaction;98%
abacavir
136470-78-5

abacavir

{(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol sulphate

{(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol sulphate

Conditions
ConditionsYield
With sulfuric acid In water; isopropyl alcohol at 50 - 55℃; for 2h; Concentration; Temperature; Solvent;95%
maleic acid
110-16-7

maleic acid

abacavir
136470-78-5

abacavir

(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol maleate
1280629-56-2

(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol maleate

Conditions
ConditionsYield
In ethanol at 25 - 30℃; for 0.25h;94.3%
4-dimethylamino-benzaldehyde
100-10-7

4-dimethylamino-benzaldehyde

abacavir
136470-78-5

abacavir

[(1S,4R)-4-(6-Cyclopropylamino-2-{[1-(4-dimethylamino-phenyl)-meth-(E)-ylidene]-amino}-purin-9-yl)-cyclopent-2-enyl]-methanol

[(1S,4R)-4-(6-Cyclopropylamino-2-{[1-(4-dimethylamino-phenyl)-meth-(E)-ylidene]-amino}-purin-9-yl)-cyclopent-2-enyl]-methanol

Conditions
ConditionsYield
With acetic acid microwave irradiation;89%
malonic acid
141-82-2

malonic acid

abacavir
136470-78-5

abacavir

(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol malonate
1280629-49-3

(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol malonate

Conditions
ConditionsYield
In ethanol at 25 - 70℃; for 0.75h; Product distribution / selectivity;88%
5-fluoro-1H-indole-2,3-dione
443-69-6

5-fluoro-1H-indole-2,3-dione

abacavir
136470-78-5

abacavir

3-[(E)-6-Cyclopropylamino-9-((1R,4S)-4-hydroxymethyl-cyclopent-2-enyl)-9H-purin-2-ylimino]-5-fluoro-1,3-dihydro-indol-2-one

3-[(E)-6-Cyclopropylamino-9-((1R,4S)-4-hydroxymethyl-cyclopent-2-enyl)-9H-purin-2-ylimino]-5-fluoro-1,3-dihydro-indol-2-one

Conditions
ConditionsYield
With acetic acid microwave irradiation;87%
2,2,2-trifluoroethyl benzoate
1579-72-2

2,2,2-trifluoroethyl benzoate

abacavir
136470-78-5

abacavir

((1S,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methyl benzoate

((1S,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methyl benzoate

Conditions
ConditionsYield
With (μ-oxo)bis[(1,2-ethanediamino-N,N'-bis(salicylidene))iron(III)] In toluene at 120℃; for 5h; Inert atmosphere; Schlenk technique; chemoselective reaction;87%
11-(acetylthio)undecanoic acid
6974-31-8

11-(acetylthio)undecanoic acid

abacavir
136470-78-5

abacavir

C27H40N6O3S

C27H40N6O3S

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0℃; for 5h;85%
1-ethenesulfonyl-piperidine
66089-45-0

1-ethenesulfonyl-piperidine

abacavir
136470-78-5

abacavir

N6-cyclopropyl-9-((1R,4S)-4-((2-(piperidin-1-ylsulfonyl)ethoxy)methyl)cyclopent-2-en-1-yl)-9H-purine-2,6-diamine

N6-cyclopropyl-9-((1R,4S)-4-((2-(piperidin-1-ylsulfonyl)ethoxy)methyl)cyclopent-2-en-1-yl)-9H-purine-2,6-diamine

Conditions
ConditionsYield
Stage #1: abacavir With silver(I) acetate; 1,2-bis-(diphenylphosphino)ethane In N,N-dimethyl-formamide at -20℃; Inert atmosphere;
Stage #2: 1-ethenesulfonyl-piperidine With potassium hexamethylsilazane In tetrahydrofuran; N,N-dimethyl-formamide at -20℃; for 21h; Inert atmosphere; regioselective reaction;
85%
abacavir
136470-78-5

abacavir

(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol dihydrobromide

(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol dihydrobromide

Conditions
ConditionsYield
With hydrogen bromide In ethanol; water at 25 - 30℃; for 0.75h; Product distribution / selectivity;83%
indole-2,3-dione
91-56-5

indole-2,3-dione

abacavir
136470-78-5

abacavir

3-[(E)-6-Cyclopropylamino-9-((1R,4S)-4-hydroxymethyl-cyclopent-2-enyl)-9H-purin-2-ylimino]-1,3-dihydro-indol-2-one

3-[(E)-6-Cyclopropylamino-9-((1R,4S)-4-hydroxymethyl-cyclopent-2-enyl)-9H-purin-2-ylimino]-1,3-dihydro-indol-2-one

Conditions
ConditionsYield
With acetic acid microwave irradiation;82%
abacavir
136470-78-5

abacavir

(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol hydrobromide
1280727-16-3

(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol hydrobromide

Conditions
ConditionsYield
With hydrogen bromide In ethanol; water at 25 - 30℃; for 0.75h; Product distribution / selectivity;82%
5-methyl-indole-2,3-dione
608-05-9

5-methyl-indole-2,3-dione

abacavir
136470-78-5

abacavir

3-[(E)-6-Cyclopropylamino-9-((1R,4S)-4-hydroxymethyl-cyclopent-2-enyl)-9H-purin-2-ylimino]-5-methyl-1,3-dihydro-indol-2-one

3-[(E)-6-Cyclopropylamino-9-((1R,4S)-4-hydroxymethyl-cyclopent-2-enyl)-9H-purin-2-ylimino]-5-methyl-1,3-dihydro-indol-2-one

Conditions
ConditionsYield
With acetic acid microwave irradiation;78%
C13H18ClN2O5P

C13H18ClN2O5P

abacavir
136470-78-5

abacavir

(S)-2-{[(1S,4R)-4-(2-Amino-6-cyclopropylamino-purin-9-yl)-cyclopent-2-enylmethoxy]-phenoxy-phosphorylamino}-propionic acid methyl ester
261909-26-6

(S)-2-{[(1S,4R)-4-(2-Amino-6-cyclopropylamino-purin-9-yl)-cyclopent-2-enylmethoxy]-phenoxy-phosphorylamino}-propionic acid methyl ester

Conditions
ConditionsYield
Stage #1: abacavir With tert-butylmagnesium chloride In tetrahydrofuran at -78℃; Inert atmosphere;
Stage #2: C13H18ClN2O5P In tetrahydrofuran at 20℃; Inert atmosphere;
76%
tert-butoxyacetic acid
13211-32-0

tert-butoxyacetic acid

abacavir
136470-78-5

abacavir

((1S,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methyl 2-(tert-butoxy)acetate

((1S,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methyl 2-(tert-butoxy)acetate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 25 - 30℃;74%
tetra(n-butyl)ammonium hydroxide
2052-49-5

tetra(n-butyl)ammonium hydroxide

abacavir
136470-78-5

abacavir

C14H17N6O4P(2-)*2C16H36N(1+)

C14H17N6O4P(2-)*2C16H36N(1+)

Conditions
ConditionsYield
Stage #1: abacavir With pyridine; water; trichlorophosphate In acetonitrile at 0℃;
Stage #2: With water; ammonium bicarbonate In acetonitrile at 0℃; pH=8;
Stage #3: tetra(n-butyl)ammonium hydroxide In water; acetonitrile
72%
abacavir
136470-78-5

abacavir

4-Hydroxyacetophenone
99-93-4

4-Hydroxyacetophenone

4-{1-[(E)-6-Cyclopropylamino-9-((1R,4S)-4-hydroxymethyl-cyclopent-2-enyl)-9H-purin-2-ylimino]-ethyl}-phenol

4-{1-[(E)-6-Cyclopropylamino-9-((1R,4S)-4-hydroxymethyl-cyclopent-2-enyl)-9H-purin-2-ylimino]-ethyl}-phenol

Conditions
ConditionsYield
With acetic acid microwave irradiation;71%
tetra(n-butyl)ammonium hydroxide
2052-49-5

tetra(n-butyl)ammonium hydroxide

abacavir
136470-78-5

abacavir

abacavir monophosphate 1.15*nBu4N+ salt

abacavir monophosphate 1.15*nBu4N+ salt

Conditions
ConditionsYield
Stage #1: abacavir With trichlorophosphate at 0℃; for 1h; Inert atmosphere;
Stage #2: With water for 1h; Cooling with ice;
Stage #3: tetra(n-butyl)ammonium hydroxide In water pH=7.0;
71%
4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

abacavir
136470-78-5

abacavir

[(1S,4R)-4-(6-Cyclopropylamino-2-{[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-amino}-purin-9-yl)-cyclopent-2-enyl]-methanol

[(1S,4R)-4-(6-Cyclopropylamino-2-{[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-amino}-purin-9-yl)-cyclopent-2-enyl]-methanol

Conditions
ConditionsYield
With acetic acid microwave irradiation;70%
1,10-decanedioic acid
111-20-6

1,10-decanedioic acid

abacavir
136470-78-5

abacavir

C38H50N12O4

C38H50N12O4

Conditions
ConditionsYield
Stage #1: 1,10-decanedioic acid With dmap; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; diisopropylamine In N,N-dimethyl-formamide at -20℃; for 0.333333h;
Stage #2: abacavir In N,N-dimethyl-formamide at -20 - 20℃; for 16h;
70%

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