1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s
Cas:151767-02-1
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Type:Lab/Research institutions
inquiryHubei Lidu New Materials Technology Co. , Ltd. is located in No. 12,3C Industrial Park, Zhongxiang Economic Development Zone, Hubei Province. The company is committed to fine chemical raw materials, pharmaceutical intermediates and other production,
Cas:151767-02-1
Min.Order:1 Gram
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inquiryAs a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch
Cas:151767-02-1
Min.Order:1 Kilogram
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inquiryReason for Choosing us: 1): Superior Quality and Competitive Price: Our company is a renowned pharmaceutical manufacturer with more than 15 years experiences in China and all powders are supplying from our factory directly. 2): Fast ,Sa
Cas:151767-02-1
Min.Order:1 Kilogram
FOB Price: $1.0 / 3.0
Type:Manufacturers
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White Powder Storage:-20°C Freezer, Under Inert Atmosphere Pa
Cas:151767-02-1
Min.Order:1 Kilogram
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Type:Trading Company
inquiryT he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality service Appearance:White
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
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Cas:151767-02-1
Min.Order:1 Gram
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Type:Manufacturers
inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Cas:151767-02-1
Min.Order:5 Kiloliter
FOB Price: $1.2 / 5.0
Type:Manufacturers
inquiryTIANFUCHEM-- 151767-02-1--High purity Montelukast sodium in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable busin
Cas:151767-02-1
Min.Order:1 Metric Ton
FOB Price: $2000.0
Type:Lab/Research institutions
inquiryOur advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be sent
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Min.Order:1 Kilogram
FOB Price: $9.0 / 99.0
Type:Trading Company
inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:151767-02-1
Min.Order:10 Gram
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Type:Trading Company
inquiryOur Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We
Cas:151767-02-1
Min.Order:10 Kilogram
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Type:Trading Company
inquiryAdvantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:151767-02-1
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inquiryCAS Number:151767-02-1 Name:Montelukast sodium Formula:C35H35ClNNaO3S Molecular Weight:608.17 Synonyms:Cyclopropaneacetic acid,1-[[[(1R)-1-[3-[(1E)-2-(7-chloro-2- quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy- 1-methylethyl)phenyl]propyl]thio]
Cas:151767-02-1
Min.Order:1 Kilogram
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Type:Other
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white crystalline powder Storage:Store in sealed containers
Cas:151767-02-1
Min.Order:100 Gram
Negotiable
Type:Other
inquiry1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
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Min.Order:1 Kilogram
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inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:151767-02-1
Min.Order:10 Gram
FOB Price: $3.5
Type:Trading Company
inquiryMontelukast sodium Basic information Product Name: Montelukast sodium Synonyms: singulair;MONTELUKAST NA;MONTELUKAST SODIUM;mk-476;2-[1-[[1-[3-[2-[(7-chloro-2-quinolyl)]vinyl]phenyl]-3-[2-(1-hydroxy-1-methyl-ethyl)phenyl]-propyl]sulfanylmethyl]cyclo
Cas:151767-02-1
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
inquiryWe can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C
Cas:151767-02-1
Min.Order:1 Gram
Negotiable
Type:Trading Company
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Cas:151767-02-1
Min.Order:1 Kilogram
FOB Price: $4800.0 / 5000.0
Type:Trading Company
inquiryBeluga chemical professional supply High-quality Montelukast sodium CAS 151767-02-1 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in C
Cas:151767-02-1
Min.Order:1 Gram
Negotiable
Type:Lab/Research institutions
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Cas:151767-02-1
Min.Order:0 Metric Ton
Negotiable
Type:Trading Company
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Cas:151767-02-1
Min.Order:1 Kilogram
Negotiable
Type:Lab/Research institutions
inquiryMontelukast sodium CAS: 151767-02-1 Specification Item Standard Structural data confirmation 1. H-NMR: The data of structure are identical with reference standard 2. HPLC-MS: Ensu
Cas:151767-02-1
Min.Order:1 Kilogram
Negotiable
Type:Other
inquiryHenan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod
Product Detail Minimum Order Qty. 10 Gram
Cas:151767-02-1
Min.Order:10 Gram
Negotiable
Type:Trading Company
inquiryAppearance:off-white to white solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:As customer request Port:Qingda
Cas:151767-02-1
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryOur Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter
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Min.Order:1 Kilogram
FOB Price: $1.0 / 100000.0
Type:Lab/Research institutions
inquiryProduct Name:Montelukast sodium CAS No.:151767-02-1 MF:C35H35ClNNaO3S MW:608.17 Assay : 98% EINECS NO : 604-813-7 Shipping: Timely delivery after your payment Advantages: We could give you: 1.Lower Price with higher quality; 2.Professional
Cas:151767-02-1
Min.Order:100 Gram
Negotiable
Type:Lab/Research institutions
inquiryConditions | Yield |
---|---|
In methanol; toluene at 20℃; for 1h; Product distribution / selectivity; | 100% |
In methanol; toluene at 2 - 20℃; for 0.75h; Product distribution / selectivity; | 100% |
In methanol at 20℃; for 1h; Product distribution / selectivity; | 73% |
In methanol at 25 - 35℃; for 0.166667h; |
montelukast
Montelukast sodium
Conditions | Yield |
---|---|
With sodium hydroxide In methanol; toluene at 20℃; for 1h; | 100% |
With sodium hydroxide In methanol; water; toluene for 0.5h; Product distribution / selectivity; Alkaline aqueous solution; | 98% |
With sodium hydroxide In methanol at -5 - 35℃; for 1h; | 98.7% |
1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid dicyclohexylamine salt
Montelukast sodium
Conditions | Yield |
---|---|
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid dicyclohexylamine salt With acetic acid In dichloromethane pH=4 - 4.5; Stage #2: With pyrographite; sodium hydroxide In methanol; water for 1h; | 99% |
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid dicyclohexylamine salt With acetic acid In dichloromethane; water pH=4 - 4.5; Stage #2: With pyrographite; sodium hydroxide In methanol; water for 1h; | 99% |
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid dicyclohexylamine salt With acetic acid In water; toluene at 20℃; for 0.166667h; Inert atmosphere; Stage #2: With sodium hydroxide In methanol at 20 - 25℃; for 2h; Inert atmosphere; | 94% |
1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid α-methylbenzylamine salt
Montelukast sodium
Conditions | Yield |
---|---|
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid α-methylbenzylamine salt With acetic acid In dichloromethane pH=4 - 4.5; Stage #2: With pyrographite; sodium hydroxide In methanol; water for 1h; | 99% |
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid α-methylbenzylamine salt With acetic acid In dichloromethane; water pH=4 - 4.5; Stage #2: With pyrographite; sodium hydroxide In methanol; water for 1h; | 99% |
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid α-methylbenzylamine salt With acetic acid In dichloromethane; water at 25 - 35℃; for 0.75h; Stage #2: With sodium hydroxide In ethanol; dichloromethane at 25 - 30℃; for 1h; Product distribution / selectivity; | 75.6% |
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid α-methylbenzylamine salt With acetic acid In dichloromethane; water at 25 - 35℃; Stage #2: With sodium hydroxide In ethanol at 25 - 30℃; Product distribution / selectivity; | 75.6% |
1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid benzylamine salt
Montelukast sodium
Conditions | Yield |
---|---|
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid benzylamine salt With acetic acid In dichloromethane; water pH=4 - 4.5; Stage #2: With pyrographite; sodium hydroxide In methanol; water for 1h; | 99% |
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid benzylamine salt With acetic acid In dichloromethane pH=4 - 4.5; Stage #2: With pyrographite; sodium hydroxide In methanol; water for 1h; |
1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid 4-chloro benzylamine salt
Montelukast sodium
Conditions | Yield |
---|---|
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid 4-chloro benzylamine salt With acetic acid In dichloromethane pH=4 - 4.5; Stage #2: With pyrographite; sodium hydroxide In methanol; water for 1h; | 99% |
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid 4-chloro benzylamine salt With acetic acid In dichloromethane; water pH=4 - 4.5; Stage #2: With pyrographite; sodium hydroxide In methanol; water for 1h; | 99% |
Montelukast sodium
Conditions | Yield |
---|---|
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid 4-methoxy benzylamine salt With acetic acid In dichloromethane pH=4 - 4.5; Stage #2: With pyrographite; sodium hydroxide In methanol; water for 1h; | 99% |
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid 4-methoxy benzylamine salt With acetic acid In dichloromethane; water pH=4 - 4.5; Stage #2: With pyrographite; sodium hydroxide In methanol; water for 1h; | 99% |
sodium hydroxide
1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid dicyclohexylamine salt
Montelukast sodium
Conditions | Yield |
---|---|
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid dicyclohexylamine salt With water; acetic acid In toluene at 20 - 25℃; for 0.166667h; Stage #2: sodium hydroxide In ethanol; water; toluene at 20℃; for 0.333333h; | 98% |
1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid 4-bromo benzylamine salt
Montelukast sodium
Conditions | Yield |
---|---|
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid 4-bromo benzylamine salt With acetic acid In dichloromethane pH=4 - 4.5; Stage #2: With pyrographite; sodium hydroxide In methanol; water for 1h; | 98% |
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid 4-bromo benzylamine salt With acetic acid In dichloromethane; water pH=4.5; Stage #2: With pyrographite; sodium hydroxide In methanol; water for 1h; | 98% |
Montelukast sodium
Conditions | Yield |
---|---|
Stage #1: 1-(((1-(R)-(3-(2-(7-chloro-2-quinolinyl)-ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropylacetate 2-amino-1-butanol With acetic acid In dichloromethane; water for 0.25h; Stage #2: With pyrographite; sodium sulfate; sodium hydroxide In methanol at 15 - 25℃; for 1h; Temperature; | 97.2% |
montelukast isopropylamine salt
Montelukast sodium
Conditions | Yield |
---|---|
With sodium t-butanolate In toluene at 30 - 35℃; for 0.75h; Product distribution / selectivity; Inert atmosphere; Darkness; | 94% |
With sodium t-butanolate In toluene at 35℃; | 78% |
Stage #1: montelukast isopropylamine salt With hydrogenchloride In dichloromethane; water at 10 - 25℃; for 0.5h; pH=4 - 4.5; Stage #2: With sodium hydroxide In ethanol; dichloromethane at 8 - 12℃; for 2h; | |
Stage #1: montelukast isopropylamine salt With hydrogenchloride In dichloromethane; water at 10 - 20℃; pH=4 - 4.5; Inert atmosphere; Stage #2: With sodium hydroxide In ethanol; dichloromethane at 8 - 12℃; for 30h; Inert atmosphere; |
Montelukast sodium
Conditions | Yield |
---|---|
With sodium methylate; pyrographite In toluene at 25 - 30℃; for 1.5h; | 93% |
1-(((1-(R)-(3-(2-(E)-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl) thio)methyl)cyclopropaneacetic acid dipropylamine salt
Montelukast sodium
Conditions | Yield |
---|---|
Stage #1: 1-(((1-(R)-(3-(2-(E)-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl) thio)methyl)cyclopropaneacetic acid dipropylamine salt With acetic acid In water; isopropyl alcohol at 4 - 40℃; for 17h; Inert atmosphere; Stage #2: With sodium hydroxide In methanol for 1h; | 92% |
Stage #1: 1-(((1-(R)-(3-(2-(E)-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl) thio)methyl)cyclopropaneacetic acid dipropylamine salt With acetic acid In dichloromethane; water at 25 - 30℃; for 0.75h; Stage #2: With sodium hydroxide In ethanol; dichloromethane at 25 - 30℃; for 1h; Product distribution / selectivity; | 67.8% |
Stage #1: 1-(((1-(R)-(3-(2-(E)-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl) thio)methyl)cyclopropaneacetic acid dipropylamine salt With acetic acid In dichloromethane; water at 25 - 35℃; Stage #2: With sodium hydroxide In ethanol at 25 - 30℃; Product distribution / selectivity; | 67.8% |
cyclopentyl 3-{2-methoxy-4-[(o-tolylsulfonyl)carbamoyl]benzyl}-1-methyl-1H-indol-5-ylcarbamate
Montelukast sodium
Conditions | Yield |
---|---|
With sodium hydroxide In methanol at 20℃; for 0.5h; Inert atmosphere; | 92% |
montelukast N-methyl-morpholine salt
Montelukast sodium
Conditions | Yield |
---|---|
With sodium methylate In toluene at 25 - 30℃; for 0.5h; | 90% |
Montelukast sodium
Conditions | Yield |
---|---|
Stage #1: montelukast hexamethylenediamine With tartaric acid In dichloromethane; water for 0.25 - 0.333333h; Stage #2: With sodium hydroxide In methanol; dichloromethane for 0.0833333 - 0.166667h; | 90% |
Montelukast sodium
Conditions | Yield |
---|---|
Stage #1: (R,E)-2-(1-((1-(3-(2-(7-chloroquinolin-2-yl)vinyl)-phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propylthio)-methyl)cyclopropyl)acetic acid L-(-)-ephedrine With acetic acid In dichloromethane; water pH=7; Inert atmosphere; Stage #2: With sodium hydroxide In methanol for 1h; Activated carbon; | 86.8% |
Montelukast L-ephedrine salt
Montelukast sodium
Conditions | Yield |
---|---|
Stage #1: Montelukast L-ephedrine salt With acetic acid In dichloromethane; water at 15 - 20℃; pH=7; Inert atmosphere; Stage #2: With sodium hydroxide In methanol at 32℃; | 86.8% |
montelukast n-propylamine salt
Montelukast sodium
Conditions | Yield |
---|---|
With sodium t-butanolate In toluene at 30℃; | 82% |
montelukast tert-butylamine salt
Montelukast sodium
Conditions | Yield |
---|---|
Stage #1: montelukast tert-butylamine salt With acetic acid In dichloromethane; water for 0.5h; Industry scale; Stage #2: With sodium hydroxide In methanol for 0.333333h; Industry scale; | 75.4% |
With sodium methylate In methanol at 25 - 35℃; for 1h; Product distribution / selectivity; | |
Stage #1: montelukast tert-butylamine salt With acetic acid In dichloromethane; water at 25 - 35℃; for 0.25h; Stage #2: With sodium hydroxide; pyrographite In methanol at 25 - 35℃; for 0.5h; |
[R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid homoveratrylamine salt
Montelukast sodium
Conditions | Yield |
---|---|
Stage #1: [R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid homoveratrylamine salt With acetic acid In dichloromethane; water at 0 - 5℃; Stage #2: With sodium hydroxide In methanol at 25 - 35℃; Product distribution / selectivity; | 75% |
C39H43ClN2O2S
Montelukast sodium
Conditions | Yield |
---|---|
With sodium hydroxide; water; ethylene glycol at 120 - 195℃; for 3 - 25h; Product distribution / selectivity; | 60% |
(1-{1-(R)-(E)-{3-[2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid diisobutylamine salt
Montelukast sodium
Conditions | Yield |
---|---|
With sodium tert-pentoxide In methyl cyclohexane; toluene at 20 - 45℃; for 1.5h; | 56% |
With sodium tert-pentoxide In toluene at 40 - 45℃; for 0.5h; Product distribution / selectivity; Inert atmosphere; | 56% |
1-(((1(R)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)-phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)-cyclopropaneacetic acid trans-4-aminocyclohexanol salt
Montelukast sodium
Conditions | Yield |
---|---|
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)-phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)-cyclopropaneacetic acid trans-4-aminocyclohexanol salt With tartaric acid In water for 1h; Stage #2: With sodium hydroxide In methanol for 1h; Product distribution / selectivity; |
1-[[[(1R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulfanyl]methyl]cyclopropaneacetic acid cyclohexylamine salt
Montelukast sodium
Conditions | Yield |
---|---|
Stage #1: 1-[[[(1R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulfanyl]methyl]cyclopropaneacetic acid cyclohexylamine salt With tartaric acid In water for 1h; Stage #2: With sodium hydroxide In methanol for 1h; Product distribution / selectivity; |
Montelukast sodium
Conditions | Yield |
---|---|
Stage #1: 1-[[[(1R)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl] cyclopropane acetic acid magnesium salt With acetic acid In water at 25 - 30℃; for 0.5h; Stage #2: With sodium hydroxide In ethanol; water at 25 - 30℃; for 0.5h; |
1-(((1(R)-(3-(2(E)-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid methyl ester
Montelukast sodium
Conditions | Yield |
---|---|
With sodium hydroxide In tetrahydrofuran; methanol; water at 24 - 27℃; for 20h; Product distribution / selectivity; Alkaline aqueous solution; | |
With sodium hydroxide In tetrahydrofuran; methanol at 20 - 25℃; for 50h; | |
With sodium hydroxide In tetrahydrofuran; ISOPROPYLAMIDE at 40℃; for 4h; |
sodium hydroxide
montelukast tert-butylamine salt
Montelukast sodium
Conditions | Yield |
---|---|
In methanol at 5 - 10℃; for 0.5h; Product distribution / selectivity; |
sodium hydroxide
n-butylamine salt of montelukast
Montelukast sodium
Conditions | Yield |
---|---|
In methanol at 5 - 10℃; for 0.5h; Product distribution / selectivity; |
Montelukast sodium
montelukast
Conditions | Yield |
---|---|
With hydrogenchloride In water at 20 - 25℃; for 1h; | 97% |
With hydrogenchloride In water at 20℃; for 1h; pH=6; | 97.9% |
With hydrogenchloride; citric buffer In water; acetone at 20 - 25℃; for 2h; | 76% |
Conditions | Yield |
---|---|
With O4P(3-)*3K(1+)*5H2O; tris(1-adamantyl)phosphine; C28H26N2O8Pd2S2 In tetrahydrofuran at 100℃; for 5h; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique; | 89% |
Conditions | Yield |
---|---|
With O4P(3-)*3K(1+)*5H2O; tris(1-adamantyl)phosphine; {2-[((acetyl-κO)amino)phenyl-κC](tri-1-adamantylphosphine)palladium}(p-toluenesulfonate) In tetrahydrofuran at 100℃; for 5h; Suzuki-Miyaura Coupling; Inert atmosphere; | 89% |
dimethyl sulfate
Montelukast sodium
1-(((1(R)-(3-(2(E)-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid methyl ester
Conditions | Yield |
---|---|
With sodium hydroxide In 1,4-dioxane Reflux; | 54% |
Montelukast sodium
Conditions | Yield |
---|---|
With 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid In dichloromethane at -22℃; for 2h; Yield given; | |
Stage #1: Montelukast sodium With dihydrogen peroxide In methanol; water for 3h; Stage #2: With acetic acid | |
With dihydrogen peroxide In methanol; water for 3h; |
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