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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

Montelukast sodium

Cas:151767-02-1

Min.Order:1 Kilogram

FOB Price: $10.0 / 20.0

Type:Lab/Research institutions

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Hubei Lidu New Material Technology Co., Ltd

Hubei Lidu New Materials Technology Co. , Ltd. is located in No. 12,3C Industrial Park, Zhongxiang Economic Development Zone, Hubei Province. The company is committed to fine chemical raw materials, pharmaceutical intermediates and other production,

Montelukast sodium

Cas:151767-02-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Montelukast sodium Manufacturer/High quality/Best price/In stock

Cas:151767-02-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hebei yanxi chemical co.,LTD.

Reason for Choosing us: 1): Superior Quality and Competitive Price: Our company is a renowned pharmaceutical manufacturer with more than 15 years experiences in China and all powders are supplying from our factory directly. 2): Fast ,Sa

Montelukast sodium CAS No. 151767-02-1 CAS NO.151767-02-1

Cas:151767-02-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 3.0

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; ...... Appearance:White Powder Storage:-20°C Freezer, Under Inert Atmosphere Pa

High quality Montelukast sodium CAS 151767-02-1 with favorable price

Cas:151767-02-1

Min.Order:1 Kilogram

FOB Price: $500.0

Type:Trading Company

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Henan Allgreen Chemical Co.,Ltd

T he company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality service Appearance:White

Montelukast sodium

Cas:151767-02-1

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Montelukast Sodium

Cas:151767-02-1

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

High Quality 99% Montelukast sodium 151767-02-1 GMP Manufacturer

Cas:151767-02-1

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Montelukast Sodium

Cas:151767-02-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

TIANFUCHEM-- 151767-02-1--High purity Montelukast sodium in stock Our company was built in 2009 with an ISO certificate.In the past 10 years, we have grown up as a famous fine chemicals supplier in China And we had established stable busin

TIANFUCHEM-- 151767-02-1--High purity Montelukast sodium in stock

Cas:151767-02-1

Min.Order:1 Metric Ton

FOB Price: $2000.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1, High quality with competitive price: 1) Standard:BP/USP/EP/Enterprise standard 2) All Purity≥99% 3) We are manufacturer and can provide high quality products with factory price. 2, Fast and safe delivery 1) Parcel can be sent

Montelukast sodium

Cas:151767-02-1

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Wholesale price CAS 151767-02-1 with best quality

Cas:151767-02-1

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Hot Sell Factory Supply Raw Material CAS 151767-02-1 Montelukast sodium

Cas:151767-02-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Montelukast sodium/ LIDE PHARMA- Factory supply / Best price

Cas:151767-02-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Sinotech Import&Export Corporation

CAS Number:151767-02-1 Name:Montelukast sodium Formula:C35H35ClNNaO3S Molecular Weight:608.17 Synonyms:Cyclopropaneacetic acid,1-[[[(1R)-1-[3-[(1E)-2-(7-chloro-2- quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy- 1-methylethyl)phenyl]propyl]thio]

Montelukast Sodium 151767-02-1

Cas:151767-02-1

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:white crystalline powder Storage:Store in sealed containers

Anti-Inflammatory Drugs CAS: 151767-02-1 Montelukast Sodium Powder

Cas:151767-02-1

Min.Order:100 Gram

Negotiable

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Montelukast sodium 151767-02-1

Cas:151767-02-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Shanghai Minstar Chemical Co., Ltd

Montelukast sodium Basic information Product Name: Montelukast sodium Synonyms: singulair;MONTELUKAST NA;MONTELUKAST SODIUM;mk-476;2-[1-[[1-[3-[2-[(7-chloro-2-quinolyl)]vinyl]phenyl]-3-[2-(1-hydroxy-1-methyl-ethyl)phenyl]-propyl]sulfanylmethyl]cyclo

Montelukast sodium

Cas:151767-02-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Montelukast sodium manufacturer with low price

Cas:151767-02-1

Min.Order:1 Gram

Negotiable

Type:Trading Company

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Baoji Guokang Healthchem co.,ltd

1.Strong backup of factory:hign ability,favorable quality and competitive price. 2.Most of our products in catalogue are have stock. 3.Free sample could be provided. 4.Suitable package to protect the product the product quality. 5.the lead time

Best Quality,Montelukast sodium

Cas:151767-02-1

Min.Order:1 Kilogram

FOB Price: $4800.0 / 5000.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

Beluga chemical professional supply High-quality Montelukast sodium CAS 151767-02-1 1. Beluga Chemical has a professional RESEARCH and development team and strong technical force to ensure technical support and research capabilities. 2. Made in C

High-quality Montelukast sodium CAS 151767-02-1

Cas:151767-02-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shanghai Terui OP New Material Technology Co., Ltd.

We have overseas warehouses in California, New Laredo Mexico, Vancouver Canada, Amsterdam Netherlands, and Melbourne Australia. Overseas warehouses can provide some of the best-selling products. We look forward to the cooperation of local powerful

151767-02-1 Montelukast sodium

Cas:151767-02-1

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Montelukast sodium

Cas:151767-02-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Lonwin Chemical Group Limited

Montelukast sodium CAS: 151767-02-1 Specification Item Standard Structural data confirmation 1. H-NMR: The data of structure are identical with reference standard 2. HPLC-MS: Ensu

Factory supply Montelukast sodium

Cas:151767-02-1

Min.Order:1 Kilogram

Negotiable

Type:Other

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Montelukast sodium

Cas:151767-02-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram

Montelukast Sodium in stock CAS 151767-02-1 CAS NO.151767-02-1

Cas:151767-02-1

Min.Order:10 Gram

Negotiable

Type:Trading Company

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Triumph International Development Limilted

Appearance:off-white to white solid Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for Synthesis API and Research Transportation:As customer request Port:Qingda

Montelukast Sodium 151767-02-1

Cas:151767-02-1

Min.Order:1 Kilogram

FOB Price: $10.0

Type:Lab/Research institutions

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Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Montelukast sodium

Cas:151767-02-1

Min.Order:1 Kilogram

FOB Price: $1.0 / 100000.0

Type:Lab/Research institutions

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Zhengzhou Yuanli Biological Technology Co., Ltd.

Product Name:Montelukast sodium CAS No.:151767-02-1 MF:C35H35ClNNaO3S MW:608.17 Assay : 98% EINECS NO : 604-813-7 Shipping: Timely delivery after your payment Advantages: We could give you: 1.Lower Price with higher quality; 2.Professional

98% singulair Manufacturer;Montelukast sodium

Cas:151767-02-1

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Synthetic route

sodium hydroxide
1310-73-2

sodium hydroxide

montelukast
158966-92-8

montelukast

Montelukast sodium
151767-02-1

Montelukast sodium

Conditions
ConditionsYield
In methanol; toluene at 20℃; for 1h; Product distribution / selectivity;100%
In methanol; toluene at 2 - 20℃; for 0.75h; Product distribution / selectivity;100%
In methanol at 20℃; for 1h; Product distribution / selectivity;73%
In methanol at 25 - 35℃; for 0.166667h;
montelukast
158966-92-8

montelukast

Montelukast sodium
151767-02-1

Montelukast sodium

Conditions
ConditionsYield
With sodium hydroxide In methanol; toluene at 20℃; for 1h;100%
With sodium hydroxide In methanol; water; toluene for 0.5h; Product distribution / selectivity; Alkaline aqueous solution;98%
With sodium hydroxide In methanol at -5 - 35℃; for 1h;98.7%
1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid dicyclohexylamine salt
577953-88-9

1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid dicyclohexylamine salt

Montelukast sodium
151767-02-1

Montelukast sodium

Conditions
ConditionsYield
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid dicyclohexylamine salt With acetic acid In dichloromethane pH=4 - 4.5;
Stage #2: With pyrographite; sodium hydroxide In methanol; water for 1h;
99%
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid dicyclohexylamine salt With acetic acid In dichloromethane; water pH=4 - 4.5;
Stage #2: With pyrographite; sodium hydroxide In methanol; water for 1h;
99%
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid dicyclohexylamine salt With acetic acid In water; toluene at 20℃; for 0.166667h; Inert atmosphere;
Stage #2: With sodium hydroxide In methanol at 20 - 25℃; for 2h; Inert atmosphere;
94%
1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid α-methylbenzylamine salt
880769-29-9

1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid α-methylbenzylamine salt

Montelukast sodium
151767-02-1

Montelukast sodium

Conditions
ConditionsYield
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid α-methylbenzylamine salt With acetic acid In dichloromethane pH=4 - 4.5;
Stage #2: With pyrographite; sodium hydroxide In methanol; water for 1h;
99%
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid α-methylbenzylamine salt With acetic acid In dichloromethane; water pH=4 - 4.5;
Stage #2: With pyrographite; sodium hydroxide In methanol; water for 1h;
99%
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid α-methylbenzylamine salt With acetic acid In dichloromethane; water at 25 - 35℃; for 0.75h;
Stage #2: With sodium hydroxide In ethanol; dichloromethane at 25 - 30℃; for 1h; Product distribution / selectivity;
75.6%
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid α-methylbenzylamine salt With acetic acid In dichloromethane; water at 25 - 35℃;
Stage #2: With sodium hydroxide In ethanol at 25 - 30℃; Product distribution / selectivity;
75.6%
1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid benzylamine salt
1100021-03-1

1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid benzylamine salt

Montelukast sodium
151767-02-1

Montelukast sodium

Conditions
ConditionsYield
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid benzylamine salt With acetic acid In dichloromethane; water pH=4 - 4.5;
Stage #2: With pyrographite; sodium hydroxide In methanol; water for 1h;
99%
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid benzylamine salt With acetic acid In dichloromethane pH=4 - 4.5;
Stage #2: With pyrographite; sodium hydroxide In methanol; water for 1h;
1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid 4-chloro benzylamine salt
1254938-23-2

1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid 4-chloro benzylamine salt

Montelukast sodium
151767-02-1

Montelukast sodium

Conditions
ConditionsYield
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid 4-chloro benzylamine salt With acetic acid In dichloromethane pH=4 - 4.5;
Stage #2: With pyrographite; sodium hydroxide In methanol; water for 1h;
99%
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid 4-chloro benzylamine salt With acetic acid In dichloromethane; water pH=4 - 4.5;
Stage #2: With pyrographite; sodium hydroxide In methanol; water for 1h;
99%
1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid 4-methoxy benzylamine salt

1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid 4-methoxy benzylamine salt

Montelukast sodium
151767-02-1

Montelukast sodium

Conditions
ConditionsYield
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid 4-methoxy benzylamine salt With acetic acid In dichloromethane pH=4 - 4.5;
Stage #2: With pyrographite; sodium hydroxide In methanol; water for 1h;
99%
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid 4-methoxy benzylamine salt With acetic acid In dichloromethane; water pH=4 - 4.5;
Stage #2: With pyrographite; sodium hydroxide In methanol; water for 1h;
99%
sodium hydroxide
1310-73-2

sodium hydroxide

1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid dicyclohexylamine salt
577953-88-9

1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid dicyclohexylamine salt

Montelukast sodium
151767-02-1

Montelukast sodium

Conditions
ConditionsYield
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid dicyclohexylamine salt With water; acetic acid In toluene at 20 - 25℃; for 0.166667h;
Stage #2: sodium hydroxide In ethanol; water; toluene at 20℃; for 0.333333h;
98%
1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid 4-bromo benzylamine salt
1254938-26-5

1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid 4-bromo benzylamine salt

Montelukast sodium
151767-02-1

Montelukast sodium

Conditions
ConditionsYield
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid 4-bromo benzylamine salt With acetic acid In dichloromethane pH=4 - 4.5;
Stage #2: With pyrographite; sodium hydroxide In methanol; water for 1h;
98%
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinil)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid 4-bromo benzylamine salt With acetic acid In dichloromethane; water pH=4.5;
Stage #2: With pyrographite; sodium hydroxide In methanol; water for 1h;
98%
1-(((1-(R)-(3-(2-(7-chloro-2-quinolinyl)-ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropylacetate 2-amino-1-butanol

1-(((1-(R)-(3-(2-(7-chloro-2-quinolinyl)-ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropylacetate 2-amino-1-butanol

Montelukast sodium
151767-02-1

Montelukast sodium

Conditions
ConditionsYield
Stage #1: 1-(((1-(R)-(3-(2-(7-chloro-2-quinolinyl)-ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropylacetate 2-amino-1-butanol With acetic acid In dichloromethane; water for 0.25h;
Stage #2: With pyrographite; sodium sulfate; sodium hydroxide In methanol at 15 - 25℃; for 1h; Temperature;
97.2%
montelukast isopropylamine salt
918972-53-9

montelukast isopropylamine salt

Montelukast sodium
151767-02-1

Montelukast sodium

Conditions
ConditionsYield
With sodium t-butanolate In toluene at 30 - 35℃; for 0.75h; Product distribution / selectivity; Inert atmosphere; Darkness;94%
With sodium t-butanolate In toluene at 35℃;78%
Stage #1: montelukast isopropylamine salt With hydrogenchloride In dichloromethane; water at 10 - 25℃; for 0.5h; pH=4 - 4.5;
Stage #2: With sodium hydroxide In ethanol; dichloromethane at 8 - 12℃; for 2h;
Stage #1: montelukast isopropylamine salt With hydrogenchloride In dichloromethane; water at 10 - 20℃; pH=4 - 4.5; Inert atmosphere;
Stage #2: With sodium hydroxide In ethanol; dichloromethane at 8 - 12℃; for 30h; Inert atmosphere;
1-[[[(1R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulfanyl]methyl]cyclopropaneacetic acid R-(+)-α-methylbenzylamine salt

1-[[[(1R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulfanyl]methyl]cyclopropaneacetic acid R-(+)-α-methylbenzylamine salt

Montelukast sodium
151767-02-1

Montelukast sodium

Conditions
ConditionsYield
With sodium methylate; pyrographite In toluene at 25 - 30℃; for 1.5h;93%
1-(((1-(R)-(3-(2-(E)-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl) thio)methyl)cyclopropaneacetic acid dipropylamine salt
880769-26-6

1-(((1-(R)-(3-(2-(E)-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl) thio)methyl)cyclopropaneacetic acid dipropylamine salt

Montelukast sodium
151767-02-1

Montelukast sodium

Conditions
ConditionsYield
Stage #1: 1-(((1-(R)-(3-(2-(E)-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl) thio)methyl)cyclopropaneacetic acid dipropylamine salt With acetic acid In water; isopropyl alcohol at 4 - 40℃; for 17h; Inert atmosphere;
Stage #2: With sodium hydroxide In methanol for 1h;
92%
Stage #1: 1-(((1-(R)-(3-(2-(E)-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl) thio)methyl)cyclopropaneacetic acid dipropylamine salt With acetic acid In dichloromethane; water at 25 - 30℃; for 0.75h;
Stage #2: With sodium hydroxide In ethanol; dichloromethane at 25 - 30℃; for 1h; Product distribution / selectivity;
67.8%
Stage #1: 1-(((1-(R)-(3-(2-(E)-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl) thio)methyl)cyclopropaneacetic acid dipropylamine salt With acetic acid In dichloromethane; water at 25 - 35℃;
Stage #2: With sodium hydroxide In ethanol at 25 - 30℃; Product distribution / selectivity;
67.8%
cyclopentyl 3-{2-methoxy-4-[(o-tolylsulfonyl)carbamoyl]benzyl}-1-methyl-1H-indol-5-ylcarbamate
142522-28-9

cyclopentyl 3-{2-methoxy-4-[(o-tolylsulfonyl)carbamoyl]benzyl}-1-methyl-1H-indol-5-ylcarbamate

Montelukast sodium
151767-02-1

Montelukast sodium

Conditions
ConditionsYield
With sodium hydroxide In methanol at 20℃; for 0.5h; Inert atmosphere;92%
montelukast N-methyl-morpholine salt
942303-96-0

montelukast N-methyl-morpholine salt

Montelukast sodium
151767-02-1

Montelukast sodium

Conditions
ConditionsYield
With sodium methylate In toluene at 25 - 30℃; for 0.5h;90%
montelukast hexamethylenediamine

montelukast hexamethylenediamine

Montelukast sodium
151767-02-1

Montelukast sodium

Conditions
ConditionsYield
Stage #1: montelukast hexamethylenediamine With tartaric acid In dichloromethane; water for 0.25 - 0.333333h;
Stage #2: With sodium hydroxide In methanol; dichloromethane for 0.0833333 - 0.166667h;
90%
(R,E)-2-(1-((1-(3-(2-(7-chloroquinolin-2-yl)vinyl)-phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propylthio)-methyl)cyclopropyl)acetic acid L-(-)-ephedrine

(R,E)-2-(1-((1-(3-(2-(7-chloroquinolin-2-yl)vinyl)-phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propylthio)-methyl)cyclopropyl)acetic acid L-(-)-ephedrine

Montelukast sodium
151767-02-1

Montelukast sodium

Conditions
ConditionsYield
Stage #1: (R,E)-2-(1-((1-(3-(2-(7-chloroquinolin-2-yl)vinyl)-phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propylthio)-methyl)cyclopropyl)acetic acid L-(-)-ephedrine With acetic acid In dichloromethane; water pH=7; Inert atmosphere;
Stage #2: With sodium hydroxide In methanol for 1h; Activated carbon;
86.8%
Montelukast L-ephedrine salt
1312993-47-7

Montelukast L-ephedrine salt

Montelukast sodium
151767-02-1

Montelukast sodium

Conditions
ConditionsYield
Stage #1: Montelukast L-ephedrine salt With acetic acid In dichloromethane; water at 15 - 20℃; pH=7; Inert atmosphere;
Stage #2: With sodium hydroxide In methanol at 32℃;
86.8%
montelukast n-propylamine salt
1100021-00-8

montelukast n-propylamine salt

Montelukast sodium
151767-02-1

Montelukast sodium

Conditions
ConditionsYield
With sodium t-butanolate In toluene at 30℃;82%
montelukast tert-butylamine salt
851755-58-3

montelukast tert-butylamine salt

Montelukast sodium
151767-02-1

Montelukast sodium

Conditions
ConditionsYield
Stage #1: montelukast tert-butylamine salt With acetic acid In dichloromethane; water for 0.5h; Industry scale;
Stage #2: With sodium hydroxide In methanol for 0.333333h; Industry scale;
75.4%
With sodium methylate In methanol at 25 - 35℃; for 1h; Product distribution / selectivity;
Stage #1: montelukast tert-butylamine salt With acetic acid In dichloromethane; water at 25 - 35℃; for 0.25h;
Stage #2: With sodium hydroxide; pyrographite In methanol at 25 - 35℃; for 0.5h;
[R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid homoveratrylamine salt
1187364-41-5

[R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid homoveratrylamine salt

Montelukast sodium
151767-02-1

Montelukast sodium

Conditions
ConditionsYield
Stage #1: [R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid homoveratrylamine salt With acetic acid In dichloromethane; water at 0 - 5℃;
Stage #2: With sodium hydroxide In methanol at 25 - 35℃; Product distribution / selectivity;
75%
C39H43ClN2O2S
1020313-99-8

C39H43ClN2O2S

Montelukast sodium
151767-02-1

Montelukast sodium

Conditions
ConditionsYield
With sodium hydroxide; water; ethylene glycol at 120 - 195℃; for 3 - 25h; Product distribution / selectivity;60%
(1-{1-(R)-(E)-{3-[2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid diisobutylamine salt
1399184-58-7

(1-{1-(R)-(E)-{3-[2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid diisobutylamine salt

Montelukast sodium
151767-02-1

Montelukast sodium

Conditions
ConditionsYield
With sodium tert-pentoxide In methyl cyclohexane; toluene at 20 - 45℃; for 1.5h;56%
With sodium tert-pentoxide In toluene at 40 - 45℃; for 0.5h; Product distribution / selectivity; Inert atmosphere;56%
1-(((1(R)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)-phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)-cyclopropaneacetic acid trans-4-aminocyclohexanol salt
1008509-41-8

1-(((1(R)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)-phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)-cyclopropaneacetic acid trans-4-aminocyclohexanol salt

Montelukast sodium
151767-02-1

Montelukast sodium

Conditions
ConditionsYield
Stage #1: 1-(((1(R)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)-phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)-cyclopropaneacetic acid trans-4-aminocyclohexanol salt With tartaric acid In water for 1h;
Stage #2: With sodium hydroxide In methanol for 1h; Product distribution / selectivity;
1-[[[(1R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulfanyl]methyl]cyclopropaneacetic acid cyclohexylamine salt
945934-73-6

1-[[[(1R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulfanyl]methyl]cyclopropaneacetic acid cyclohexylamine salt

Montelukast sodium
151767-02-1

Montelukast sodium

Conditions
ConditionsYield
Stage #1: 1-[[[(1R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulfanyl]methyl]cyclopropaneacetic acid cyclohexylamine salt With tartaric acid In water for 1h;
Stage #2: With sodium hydroxide In methanol for 1h; Product distribution / selectivity;
1-[[[(1R)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl] cyclopropane acetic acid magnesium salt

1-[[[(1R)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl] cyclopropane acetic acid magnesium salt

Montelukast sodium
151767-02-1

Montelukast sodium

Conditions
ConditionsYield
Stage #1: 1-[[[(1R)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl] cyclopropane acetic acid magnesium salt With acetic acid In water at 25 - 30℃; for 0.5h;
Stage #2: With sodium hydroxide In ethanol; water at 25 - 30℃; for 0.5h;
1-(((1(R)-(3-(2(E)-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid methyl ester
855473-51-7

1-(((1(R)-(3-(2(E)-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid methyl ester

Montelukast sodium
151767-02-1

Montelukast sodium

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran; methanol; water at 24 - 27℃; for 20h; Product distribution / selectivity; Alkaline aqueous solution;
With sodium hydroxide In tetrahydrofuran; methanol at 20 - 25℃; for 50h;
With sodium hydroxide In tetrahydrofuran; ISOPROPYLAMIDE at 40℃; for 4h;
sodium hydroxide
1310-73-2

sodium hydroxide

montelukast tert-butylamine salt
851755-58-3

montelukast tert-butylamine salt

Montelukast sodium
151767-02-1

Montelukast sodium

Conditions
ConditionsYield
In methanol at 5 - 10℃; for 0.5h; Product distribution / selectivity;
sodium hydroxide
1310-73-2

sodium hydroxide

n-butylamine salt of montelukast
1028683-07-9

n-butylamine salt of montelukast

Montelukast sodium
151767-02-1

Montelukast sodium

Conditions
ConditionsYield
In methanol at 5 - 10℃; for 0.5h; Product distribution / selectivity;
Montelukast sodium
151767-02-1

Montelukast sodium

montelukast
158966-92-8

montelukast

Conditions
ConditionsYield
With hydrogenchloride In water at 20 - 25℃; for 1h;97%
With hydrogenchloride In water at 20℃; for 1h; pH=6;97.9%
With hydrogenchloride; citric buffer In water; acetone at 20 - 25℃; for 2h;76%
3,4,5-trifluorophenylboronic acid
143418-49-9

3,4,5-trifluorophenylboronic acid

Montelukast sodium
151767-02-1

Montelukast sodium

C41H38F3NO3S

C41H38F3NO3S

Conditions
ConditionsYield
With O4P(3-)*3K(1+)*5H2O; tris(1-adamantyl)phosphine; C28H26N2O8Pd2S2 In tetrahydrofuran at 100℃; for 5h; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique;89%
3,4,5-trifluorophenylboronic acid
143418-49-9

3,4,5-trifluorophenylboronic acid

Montelukast sodium
151767-02-1

Montelukast sodium

C41H38F3NO3S

C41H38F3NO3S

Conditions
ConditionsYield
With O4P(3-)*3K(1+)*5H2O; tris(1-adamantyl)phosphine; {2-[((acetyl-κO)amino)phenyl-κC](tri-1-adamantylphosphine)palladium}(p-toluenesulfonate) In tetrahydrofuran at 100℃; for 5h; Suzuki-Miyaura Coupling; Inert atmosphere;89%
dimethyl sulfate
77-78-1

dimethyl sulfate

Montelukast sodium
151767-02-1

Montelukast sodium

1-(((1(R)-(3-(2(E)-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid methyl ester
855473-51-7

1-(((1(R)-(3-(2(E)-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane acetic acid methyl ester

Conditions
ConditionsYield
With sodium hydroxide In 1,4-dioxane Reflux;54%
Montelukast sodium
151767-02-1

Montelukast sodium

[R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl) ethenyl]-phenyl]-3-[2-(-hydroxy-1-methylethyl) phenyl]propyl]-sulfinyl] methyl] cyclopropaneacetic acid

[R,E]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl) ethenyl]-phenyl]-3-[2-(-hydroxy-1-methylethyl) phenyl]propyl]-sulfinyl] methyl] cyclopropaneacetic acid

Conditions
ConditionsYield
With 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid In dichloromethane at -22℃; for 2h; Yield given;
Stage #1: Montelukast sodium With dihydrogen peroxide In methanol; water for 3h;
Stage #2: With acetic acid
With dihydrogen peroxide In methanol; water for 3h;

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