high quality ,iso , cgmp . accept the supplier audit . in stock now ,capacity is flexible support the documents Appearance:white powder Storage: protect from light seal room temperature Package:DRUM Application:API Port:SHANGHAI
Cas:154229-19-3
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inquiryGOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation
Introduction Abiraterone acetate, the active ingredient of ZYTIGA is the acetyl ester of abiraterone. Abiraterone is an inhibitor of CYP17 (17α-hydroxylase/C17,20-lyase). Each ZYTIGA tablet contains 250 mg of abiraterone acetate. Abira
Unique advantages of Abiraterone Cas 154229-19-3 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White or off-white crystalline powder Storage:Cool dry place Package:100g
Cas:154229-19-3
Min.Order:100 Gram
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inquiryhigh quality Appearance:white powder Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Cas:154229-19-3
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:154229-19-3
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inquiryShanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu
Cas:154229-19-3
Min.Order:1 Kilogram
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inquiryDayangChem exported this product to many countries and regions at best price in China. If you are looking for the product’s supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product specifica
Cas:154229-19-3
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inquiryhebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm
Cas:154229-19-3
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inquiryOur main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block
Name:Abiraterone The alias:abChemicalbookiraterone;Androsta-5,16-dien-3-ol,17-(3-pyridinyl)-,(3beta)-;Cb7598;Cb-7598;Unii-G819A456D0;Abiraterone(CB-7598);17-(3-Pyridyl)androsta-5,16-dien-3beta-ol;CB-7598;CB7598;CB7598 CAS NO:154229-19-3 EINECS NO
Cas:154229-19-3
Min.Order:25 Kilogram
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inquiryabiraterone Basic information Product Name: abiraterone Synonyms: abiraterone;17-(3-Pyridyl)androsta-5,16-dien-3beta-ol;Androsta-5,16-dien-3-ol, 17-(3-pyridinyl)-, (3beta)-;Cb 7598;Cb-75
Cas:154229-19-3
Min.Order:1 Kilogram
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu
Cas:154229-19-3
Min.Order:1 Kilogram
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inquiryWITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et
Cas:154229-19-3
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inquiry154229-19-3 Abiraterone product Name Abiraterone Synonyms 17-(3-Pyridyl)androsta-5,16-dien-3beta-ol; (3beta)-17-(pyridin-3-yl)androsta-5,16-di
Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&
Cas:154229-19-3
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiry1. Product advantages High purity, all above 98.5%, no impurities after dissolution We will test each batch to ensure quality OEM and private brand services designed for free Various cap colors available We can also provide MT1 peptide powd
Cas:154229-19-3
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inquiryAppearance:White powder Storage:Room temperature Package:25kg/drum Application:API Transportation:Express/Sea/Air Port:Any port in china
Cas:154229-19-3
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiry1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta
Cas:154229-19-3
Min.Order:10 Gram
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Type:Other
inquiryAbiraterone[CAS:154229-19-3] Abiraterone Acetate[CAS:154229-18-2] Name Abiraterone Synonyms 17-(3-Pyridyl)androsta-5,16-dien-3beta-ol Molecular Structure Molecular F
1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized
Cas:154229-19-3
Min.Order:1 Kilogram
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Type:Lab/Research institutions
inquiryWe are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery
Cas:154229-19-3
Min.Order:10 Gram
FOB Price: $3.5
Type:Trading Company
inquiryWuhan hanweishi Pharmchem Co., Ltd(Hanways chempharm) is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The leading products range are APIs, Hormones, Peptides
Cas:154229-19-3
Min.Order:100 Kilogram
FOB Price: $1.0 / 5.0
Type:Trading Company
inquiryPacking: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Appearance:white powder/ Refer to COA Storage:Refer to COA
Cas:154229-19-3
Min.Order:1 Gram
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Type:Trading Company
inquiryOur company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese
Cas:154229-19-3
Min.Order:1 Kilogram
FOB Price: $89.0 / 100.0
Type:Trading Company
inquiryAbiraterone CAS: 154229-19-3 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediat
Cas:154229-19-3
Min.Order:1 Gram
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Type:Lab/Research institutions
inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi
Cas:154229-19-3
Min.Order:10 Gram
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inquiry1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures
Cas:154229-19-3
Min.Order:1 Kilogram
FOB Price: $40.0 / 80.0
Type:Lab/Research institutions
inquiryabiraterone acetate
abiraterone
Conditions | Yield |
---|---|
With lithium hydroxide monohydrate In tetrahydrofuran; water at 0 - 20℃; for 48h; Inert atmosphere; | 99% |
With lithium hydroxide In tetrahydrofuran; methanol; water for 1h; | 96% |
With sodium hydroxide In methanol at 20℃; for 2h; Reagent/catalyst; | 95.8% |
abiraterone
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water at 20 - 30℃; for 1.5h; pH=1 - 2; | 96.6% |
With tetrabutyl ammonium fluoride In dichloromethane at 20℃; | 90% |
3-((3S,8R,9S,10R,13S,14S)-3-((tert-butyldimethylsilyl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)pyridine
abiraterone
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water at 20 - 30℃; for 1h; | 96.5% |
Stage #1: 3-((3S,8R,9S,10R,13S,14S)-3-((tert-butyldimethylsilyl)oxy)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)pyridine With tetrabutyl ammonium fluoride In tetrahydrofuran Stage #2: With water In tetrahydrofuran | 89% |
With tetrabutyl ammonium fluoride In tetrahydrofuran | 89% |
abiraterone
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water at 20 - 30℃; for 1h; | 96.1% |
abiraterone
Conditions | Yield |
---|---|
With hydrogenchloride In methanol; water at 20 - 30℃; for 4h; pH=1 - 2; | 94% |
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In tetrahydrofuran; water at 20 - 75℃; for 0.5h; | 88.8% |
17-iodo-5,16-androstadien-3-ol
3-Diethylboranylpyridine
abiraterone
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; XPhos In 1,4-dioxane for 16h; Reflux; | 75% |
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In ethanol; water at 70 - 75℃; for 22h; Solvent; Reagent/catalyst; Temperature; | 74.1% |
With bis-triphenylphosphine-palladium(II) chloride In tetrahydrofuran for 24h; Suzuki Coupling; Reflux; Autoclave; Large scale; | 72.1% |
pyridin-3-ylzinc(II) bromide
17-iodo-5,16-androstadien-3-ol
abiraterone
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide at 20℃; for 5h; | 74.5% |
17-iodo-5,16-androstadien-3-ol
pyridin-3-ylmagnesium bromide
abiraterone
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide at 35℃; for 5h; Temperature; | 72.31% |
3-Diethylboranylpyridine
17-bromo-3β-hydroxy-5α-androstan-5,16-diene
abiraterone
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In water; tert-butyl alcohol for 3h; Catalytic behavior; Solvent; Reagent/catalyst; Temperature; Suzuki Coupling; Inert atmosphere; Reflux; Large scale; | 72% |
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In water; N,N-dimethyl-formamide at 75 - 80℃; for 36h; | 71.8% |
With palladium on activated charcoal; sodium carbonate In dimethyl sulfoxide at 120℃; for 12h; |
3-Diethylboranylpyridine
abiraterone
Conditions | Yield |
---|---|
Stage #1: 3-Diethylboranylpyridine; 17-iodoandrosta-5,16-dien-3β-ol 3-acetate With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In tetrahydrofuran; water for 5h; Reflux; Large scale; Stage #2: With sodium hydroxide In methanol at 25 - 35℃; for 7h; Reagent/catalyst; Large scale; | 67.8% |
Stage #1: 3-Diethylboranylpyridine; 17-iodoandrosta-5,16-dien-3β-ol 3-acetate With bis-triphenylphosphine-palladium(II) chloride; tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 0.333333h; Stage #2: With sodium carbonate In water at 65 - 70℃; for 1.25h; | |
Stage #1: 3-Diethylboranylpyridine; 17-iodoandrosta-5,16-dien-3β-ol 3-acetate With bis-triphenylphosphine-palladium(II) chloride; tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 0.333333h; Stage #2: In tetrahydrofuran at 65 - 70℃; for 1.25h; | 34 g |
3-(dimethylboryl)pyridine
17-iodo-5,16-androstadien-3-ol
abiraterone
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate In methanol; water at 65 - 70℃; for 28h; | 65% |
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide at 20℃; for 4h; | 52.5% |
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In tetrahydrofuran; ethanol; water; toluene at 20 - 75℃; for 2.5h; Time; Suzuki Coupling; | 51.6% |
abiraterone
Conditions | Yield |
---|---|
With hydroxylamine hydrochloride In acetonitrile Reflux; | 50% |
3-Bromopyridine
dehydroepiandrosterone-17-p-toluenesulfonyl hydrazone
abiraterone
Conditions | Yield |
---|---|
Stage #1: dehydroepiandrosterone-17-p-toluenesulfonyl hydrazone With tris-(dibenzylideneacetone)dipalladium(0); lithium tert-butoxide; XPhos In 1,4-dioxane at 20℃; for 0.0833333h; Stage #2: 3-Bromopyridine With tris-(dibenzylideneacetone)dipalladium(0) In 1,4-dioxane at 120℃; for 9h; Concentration; Temperature; Inert atmosphere; | 43.1% |
With tris-(dibenzylideneacetone)dipalladium(0); lithium tert-butoxide; XPhos In 1,4-dioxane for 4h; Inert atmosphere; Reflux; | |
With tris-(dibenzylideneacetone)dipalladium(0); lithium tert-butoxide; XPhos In 1,4-dioxane for 4h; Inert atmosphere; Reflux; | |
With tris-(dibenzylideneacetone)dipalladium(0); lithium tert-butoxide; XPhos In 1,4-dioxane for 4h; Reflux; |
17-iodo-5,16-androstadien-3-ol
pyridin-3-ylzinc chloride
abiraterone
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide at 20℃; for 7h; | 35.7% |
dehydroepiandrosterone
abiraterone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 94 percent / NH2NH2*H2O, aq, NH2NH2*H2SO4 / ethanol / 120 h / Ambient temperature 2: 83 percent / I2, 1,1,3,3-tetramethylguanidine / tetrahydrofuran; diethyl ether / 1 h 3: 2 M aq. Na2CO3 / bis(triphenylphosphine)palladium(II) chloride / tetrahydrofuran / 96 h / 80 °C View Scheme |
dehydroepiandrosterone-17-hydrazone
abiraterone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 83 percent / I2, 1,1,3,3-tetramethylguanidine / tetrahydrofuran; diethyl ether / 1 h 2: 2 M aq. Na2CO3 / bis(triphenylphosphine)palladium(II) chloride / tetrahydrofuran / 96 h / 80 °C View Scheme | |
Multi-step reaction with 5 steps 1: iodine; N,N,N',N'-tetramethylguanidine / tetrahydrofuran / 1 h / Cooling with ice 2: 1H-imidazole / dichloromethane / 1 h / 20 °C 3: n-butyllithium / tetrahydrofuran / 0.17 h / -78 - -65 °C 4: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / water; tetrahydrofuran / 15 h / Inert atmosphere; Reflux 5: tetrabutyl ammonium fluoride / tetrahydrofuran View Scheme | |
Multi-step reaction with 5 steps 1.1: iodine; N,N,N',N'-tetramethylguanidine / tetrahydrofuran 2.1: 1H-imidazole / dichloromethane / 1.17 h / 20 °C 3.1: triethyl borate / tetrahydrofuran / 0.17 h / -78 °C 3.2: 0.17 h / -65 °C 4.1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / water; tetrahydrofuran; toluene / Inert atmosphere; Reflux 5.1: tetrabutyl ammonium fluoride / tetrahydrofuran View Scheme |
prasterone acetate
abiraterone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 58 percent / 2,6-di-tert-butyl-4-methylpyridine / CH2Cl2 / 12 h 2: 84 percent / bis(triphenylphosphine)palladium(II) chloride, aq. Na2CO3 / tetrahydrofuran / 1 h / 80 °C 3: 79 percent / aq. NaOH / methanol / 0.08 h / 80 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C 1.2: 2 h / -78 °C 2.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / tetrahydrofuran; water / 18 h / Inert atmosphere; Reflux 3.1: potassium hydroxide; methanol / 1.5 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: 2,6-dimethylpyridine / dichloromethane / -78 - -20 °C 2: sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; water / 1 h / 60 °C 3: potassium carbonate / methanol / 20 °C View Scheme |
3β-acetoxyandrosta-5,16-dien-17-yl trifluoromethanesulphonate
abiraterone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 84 percent / bis(triphenylphosphine)palladium(II) chloride, aq. Na2CO3 / tetrahydrofuran / 1 h / 80 °C 2: 79 percent / aq. NaOH / methanol / 0.08 h / 80 °C View Scheme | |
Multi-step reaction with 2 steps 1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / tetrahydrofuran; water / 18 h / Inert atmosphere; Reflux 2: potassium hydroxide; methanol / 1.5 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; water / 1 h / 60 °C 2: potassium carbonate / methanol / 20 °C View Scheme |
17-iodo-5,16-androstadien-3-ol
3-Diethylboranylpyridine
abiraterone
Conditions | Yield |
---|---|
With sodium carbonate |
diethyl ether
17-iodo-5,16-androstadien-3-ol
3-Diethylboranylpyridine
abiraterone
Conditions | Yield |
---|---|
With sodium carbonate In tetrahydrofuran; bis(triphenylphosphine)palladium(II) dichloride |
dehydroepiandrosterone
abiraterone
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: toluene-4-sulfonic acid / tetrahydrofuran / Inert atmosphere; Reflux 2: 1H-imidazole / dichloromethane / 2 h / 20 °C / Inert atmosphere 3: water; tris-(dibenzylideneacetone)dipalladium(0); XPhos; lithium tert-butoxide / 1,4-dioxane / 5 h / Inert atmosphere; Reflux 4: tetrabutyl ammonium fluoride / tetrahydrofuran View Scheme | |
Multi-step reaction with 4 steps 1: toluene-4-sulfonic acid / tetrahydrofuran / Inert atmosphere; Reflux 2: 1H-imidazole / dichloromethane / 3 h / 20 °C / Inert atmosphere 3: water; tris-(dibenzylideneacetone)dipalladium(0); XPhos; lithium tert-butoxide / 1,4-dioxane / 6 h / 90 °C / Inert atmosphere 4: tetrabutyl ammonium fluoride / tetrahydrofuran View Scheme | |
Multi-step reaction with 6 steps 1: hydrazinium sulfate; hydrazine hydrate / ethanol; water / 72 h / 20 °C 2: iodine; N,N,N',N'-tetramethylguanidine / tetrahydrofuran / 1 h / Cooling with ice 3: 1H-imidazole / dichloromethane / 1 h / 20 °C 4: n-butyllithium / tetrahydrofuran / 0.17 h / -78 - -65 °C 5: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / water; tetrahydrofuran / 15 h / Inert atmosphere; Reflux 6: tetrabutyl ammonium fluoride / tetrahydrofuran View Scheme |
3-((tert-butyldimethylsilyl)oxy)-17-iodo-5,16-androstadiene
abiraterone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: n-butyllithium / tetrahydrofuran / 0.17 h / -78 - -65 °C 2: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / water; tetrahydrofuran / 15 h / Inert atmosphere; Reflux 3: tetrabutyl ammonium fluoride / tetrahydrofuran View Scheme | |
Multi-step reaction with 3 steps 1.1: triethyl borate / tetrahydrofuran / 0.17 h / -78 °C 1.2: 0.17 h / -65 °C 2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / water; tetrahydrofuran; toluene / Inert atmosphere; Reflux 3.1: tetrabutyl ammonium fluoride / tetrahydrofuran View Scheme |
3-((tert-butyldimethylsilyl)oxy)-5,16-androstadien-17-boronic acid
abiraterone
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / water; tetrahydrofuran / 15 h / Inert atmosphere; Reflux 2: tetrabutyl ammonium fluoride / tetrahydrofuran View Scheme |
dehydroepiandrosterone-17-p-toluenesulfonyl hydrazone
abiraterone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1H-imidazole / dichloromethane / 2 h / 20 °C / Inert atmosphere 2: water; tris-(dibenzylideneacetone)dipalladium(0); XPhos; lithium tert-butoxide / 1,4-dioxane / 5 h / Inert atmosphere; Reflux 3: tetrabutyl ammonium fluoride / tetrahydrofuran View Scheme | |
Multi-step reaction with 3 steps 1: 1H-imidazole / dichloromethane / 2 h / 20 °C / Inert atmosphere 2: tris-(dibenzylideneacetone)dipalladium(0); XPhos; lithium tert-butoxide / 1,4-dioxane / 15 h / 110 °C / Inert atmosphere 3: tetrabutyl ammonium fluoride / tetrahydrofuran View Scheme | |
Multi-step reaction with 3 steps 1: 1H-imidazole / dichloromethane / 2.17 h / 20 °C / Inert atmosphere 2: caesium carbonate; dichloro bis(acetonitrile) palladium(II); 1,3-bis-(diphenylphosphino)propane / 1,4-dioxane / 110 °C 3: tetrabutyl ammonium fluoride / tetrahydrofuran View Scheme |
abiraterone
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1H-imidazole / dichloromethane / 3 h / 20 °C / Inert atmosphere 2: water; tris-(dibenzylideneacetone)dipalladium(0); XPhos; lithium tert-butoxide / 1,4-dioxane / 6 h / 90 °C / Inert atmosphere 3: tetrabutyl ammonium fluoride / tetrahydrofuran View Scheme | |
Multi-step reaction with 3 steps 1: 1H-imidazole / dichloromethane / 3 h / 20 °C / Inert atmosphere 2: tris-(dibenzylideneacetone)dipalladium(0); lithium tert-butoxide; XPhos / water; 1,4-dioxane / 6 h / 90 °C / Inert atmosphere 3: tetrabutyl ammonium fluoride / tetrahydrofuran View Scheme |
BOC-glycine
abiraterone
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; Inert atmosphere; | 98% |
abiraterone
17-(3-pyridine)-4,16-dieneandrost-3-one
Conditions | Yield |
---|---|
With aluminum isopropoxide In toluene; butanone Inert atmosphere; Reflux; | 97% |
With aluminum isopropoxide In cyclohexanone; toluene for 2h; Dean-Stark; Reflux; | 90% |
With aluminum isopropoxide; butanone In toluene for 16h; Oppenauer Oxidation; Reflux; Dean-Stark; | 85% |
Conditions | Yield |
---|---|
With dmap In acetone at 20 - 65℃; for 1h; | 95.3% |
With pyridine; dmap; triethylamine at 0 - 20℃; for 5h; | 95% |
With pyridine In acetonitrile Reflux; Large scale; | 91.6% |
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 6h; Inert atmosphere; | 95% |
Conditions | Yield |
---|---|
Stage #1: abiraterone With triethylamine In dichloromethane for 0.166667h; Stage #2: 1,1'-carbonyldiimidazole With dmap In dichloromethane Reflux; | 92% |
Conditions | Yield |
---|---|
Stage #1: abiraterone With pyridine; calcium chloride In tetrahydrofuran at 0℃; for 0.0833333h; Stage #2: chloroacetyl chloride In tetrahydrofuran at 0 - 20℃; for 10.5h; Solvent; Reagent/catalyst; Concentration; Temperature; | 91.3% |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In diethyl ether at 20℃; for 4h; | 85.1% |
With 2-(Dimethylamino)pyridine; triethylamine In diethyl ether; ethanol; hexane; water | 84% |
With triethylamine In ethyl acetate at 5 - 20℃; for 2h; | 83% |
abiraterone
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; Inert atmosphere; | 84% |
abiraterone
Conditions | Yield |
---|---|
With hydrazine hydrate; acetic acid In ethanol at 80℃; for 16h; | 83% |
Conditions | Yield |
---|---|
With dichloro-acetic acid In dichloromethane at 20℃; Schlenk technique; | 83% |
Acetic anhydride-d6
abiraterone
Conditions | Yield |
---|---|
With dmap In acetone at 55 - 65℃; for 2h; | 82.4% |
[Ru(2,2’:6’,2’’-terpyridine)(6,6'-dimethyl-2,2'-dipyridyl)Cl]Cl
abiraterone
Conditions | Yield |
---|---|
In ethanol; water at 80℃; for 20h; Inert atmosphere; | 81.5% |
Conditions | Yield |
---|---|
With dmap at 20℃; | 80.6% |
In tetrahydrofuran at 0℃; for 3h; Reflux; | 69% |
1-methylpiperidine-4-carboxylic acid hydrochloride
abiraterone
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; | 80% |
triisopropylsilyl chloride
abiraterone
Conditions | Yield |
---|---|
Stage #1: abiraterone With 1H-imidazole In dichloromethane at 0℃; for 0.166667h; Stage #2: triisopropylsilyl chloride In dichloromethane at 20℃; for 44h; | 80% |
abiraterone
17-(3-pyridyl)-3,6-dioxoandrosta-4,16-diene
Conditions | Yield |
---|---|
With dipyridine chromium(VI) oxide In dichloromethane at 20℃; for 4h; | 75% |
abiraterone
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane for 14h; Inert atmosphere; Cooling with ice; | 60% |
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