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inquiryFactory supply 3,3,3-Trifluoropropionic acid CAS 2516-99-6 with fast delivery Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, F
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inquiryProduct description: Product name 3,3,3-Trifluoropropionic acid CAS number 2516-99-6 Assay ≥98% Appearance Colorless transparent liquid Capacity 200mt/year Application Pharma
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inquiryhigh quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai
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inquiryProduct Name: 3,3,3-Trifluoropropionic acid Synonyms: TFPA;RARECHEM AL BE 1046;3,3,3-TRIFLUOROPROPIONIC ACID;3,3,3-Trifluoropropionic acid 98%;3,3,3-Trifluoropropionicacid98%;3,3,3-TRIFLUOROPROPANOICACID;Trifluoromethylacetic acid;prop
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inquiryAppearance:white or light yellow crystalline powder Storage:Protect packages from damage and keep them well closed. Store in a cool, well-ventilated, dry and shaded area. Avoid inhalation, ingestion and contact with eyes and ski
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inquirySuperior quality Appearance:Clear colorless liquid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used as Pharmaceutical Intermediates Transporta
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inquiryProduct name: 3,3,3-Trifluoropropionic Acid CAS No.:2516-99-6 Molecule Formula:C3H3F3O2 Molecule Weight:128.05 Purity: 98.0% Package: 25kg/drum Description:White or off-white powder Manufacture Standards:Enterprise Standard TESTI
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inquiryProduct Name: 3,3,3-Trifluoropropionic acid Synonyms: TFPA;RARECHEM AL BE 1046;Trifluoromethylacetic acid;3,3,3-TRIFLUOROPROPIONIC ACID;3,3,3-Trifluoropropionic acid 98%;3,3,3-Trifluoropropionicacid98%;3,3,3-TRIFLUOROPROPANOICACID;propanoic aci
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inquiryfactory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B
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inquiryConditions | Yield |
---|---|
With tetrabutoxytitanium; sodium molybdate; dihydrogen peroxide; calcium chloride In ethanol; water at 75 - 90℃; for 6h; Time; Inert atmosphere; | 96.1% |
With nitric acid; sodium nitrite In water at 0 - 20℃; for 4h; | 61% |
With sulfuric acid; sodium nitrite In water at 0 - 20℃; for 3h; | 61% |
3,3,3-trifluoropropionyl fluoride
3,3,3-Trifluoropropionic acid
Conditions | Yield |
---|---|
With water at 5 - 20℃; for 0.5h; | 93.4% |
With water; sodium hydroxide at 5 - 20℃; for 0.5h; | 90.2% |
methyl 3,3,3-trifluoropropionate
3,3,3-Trifluoropropionic acid
Conditions | Yield |
---|---|
With water; sodium hydroxide at 5 - 30℃; for 0.5h; | 88% |
With hydrogen bromide | 80% |
3,3,3-trifluoropropanoyl chloride
3,3,3-trifluoro-2-chloropropionyl chloride
A
3,3,3-Trifluoropropionic acid
B
2-chloro-3,3,3-trifluoropropanoic acid
Conditions | Yield |
---|---|
With water at 50℃; for 4h; Product distribution / selectivity; | A 84.5% B n/a |
3,3,3-trifluoropropanal
A
3,3,3-Trifluoropropionic acid
B
3,3,3-trifluoro-1-(3,3,3-trifluoro-1-hydroxypropoxy)propan-1-ol
C
C9H9F9O3
Conditions | Yield |
---|---|
With water at -10 - 25℃; for 0.166667 - 168h; Product distribution / selectivity; | A 0.06% B 70.9% C 0.2% |
3,3,3-trifluoropropanoyl chloride
3,3,3-Trifluoropropionic acid
Conditions | Yield |
---|---|
With water at 50℃; for 5h; Product distribution / selectivity; | 70.5% |
3,3,3-trifluoropropanal
A
3,3,3-trifluoropropanoyl chloride
B
3,3,3-Trifluoropropionic acid
C
3,3,3-trifluoro-2-chloropropionyl chloride
Conditions | Yield |
---|---|
With 2,2'-azobis(isobutyronitrile); chlorine In 2,4-dichloro-benzotrifluoride at 50℃; for 2.5h; Product distribution / selectivity; | A 62.5% B n/a C n/a |
Conditions | Yield |
---|---|
With sulfuric acid; water at 90℃; for 20h; | 61% |
2-(2,2,2-trifluoroethylidene)-1,3-dithiane
3,3,3-Trifluoropropionic acid
Conditions | Yield |
---|---|
With sulfuric acid; mercury(II) oxide In tetrahydrofuran for 26h; Heating; | 60% |
1-chloro-1,1,3,3,3-pentafluoropropane
1,1-dichloro-1,3,3,3-tetrafluoropropane
3,3,3-Trifluoropropionic acid
Conditions | Yield |
---|---|
Stage #1: 1-chloro-1,1,3,3,3-pentafluoropropane; 1,1-dichloro-1,3,3,3-tetrafluoropropane With sulfuric acid; sulfur trioxide at 100 - 125℃; for 19 - 30h; Stage #2: With water at 20℃; Product distribution / selectivity; | 22% |
Conditions | Yield |
---|---|
With sodium dichromate; sulfuric acid |
3,3,3-Trifluoropropionic acid
Conditions | Yield |
---|---|
With water |
trifluoromethyl-malonic acid dinitrile
3,3,3-Trifluoropropionic acid
Conditions | Yield |
---|---|
With hydrogenchloride |
1,1,1-tribromotrifluoroethane
carbon dioxide
A
3,3,3-Trifluoropropionic acid
Conditions | Yield |
---|---|
With water; hydrogen cation; zinc In N,N-dimethyl-formamide for 6h; irradiated by ultrasound; | A 0.1 % Spectr. B 1.0 % Spectr. |
perfluoroisobutylene
A
3,3,3-Trifluoropropionic acid
B
3,3,3-trifluoro-2-(trifluoromethyl)propanoic acid
Conditions | Yield |
---|---|
With moisture; Copper(I) trifluoromethanethiolate In acetonitrile 1.) -78 deg C, 2 h, 2.) from 55 deg C to 60 deg C, 4 h; Further byproducts given. Title compound not separated from byproducts; |
perfluoroisobutylene
A
3,3,3-Trifluoropropionic acid
B
2,2,3,3-tetra(trifluoromethyl)-perfluorobutane
Conditions | Yield |
---|---|
With moisture; Copper(I) trifluoromethanethiolate In acetonitrile 1.) -78 deg C, 2 h, 2.) from 55 deg C to 60 deg C, 4 h; Further byproducts given. Title compound not separated from byproducts; |
trifluoromethylketene
3,3,3-Trifluoropropionic acid
Conditions | Yield |
---|---|
With water Rate constant; |
3,3,3-Trifluoropropionic acid
Conditions | Yield |
---|---|
With trimethylsilyl iodide In chloroform at 65℃; for 9h; | 1.7 g |
iodotrifluoromethane
1-(tert-butyldimethylsilyloxy)-1-tert-butoxyethylene
3,3,3-Trifluoropropionic acid
Conditions | Yield |
---|---|
With triethyl borane; oxonium 1.) hexane, RT, 2h, 2.) RT, 15 h; Yield given. Multistep reaction; |
3,3,3-trifluoroprop-1-yne
sulfuric acid
A
trifluoromethan
B
1,1,1-trifluoro-2-propanone
C
3,3,3-Trifluoropropionic acid
D
methylammonium carbonate
Conditions | Yield |
---|---|
at 135℃; |
Conditions | Yield |
---|---|
In diethyl ether for 0.25h; Photolysis; |
3,3,3-trifluoropropanal dimethyl acetal
A
3,3,3-Trifluoropropionic acid
B
methyl 3,3,3-trifluoropropionate
Conditions | Yield |
---|---|
With hydrogenchloride; dihydrogen peroxide; iron(III) chloride at 80℃; for 1h; | A 95 % Chromat. B 3 % Chromat. |
3,3,3-trifluoropropanal dimethyl acetal
A
3,3,3-trifluoropropanal
B
3,3,3-Trifluoropropionic acid
C
methyl 3,3,3-trifluoropropionate
Conditions | Yield |
---|---|
With copper(I) oxide; hydrogenchloride; dihydrogen peroxide at 80℃; | A 2 % Chromat. B 91 % Chromat. C 7 % Chromat. |
With hydrogenchloride; dihydrogen peroxide; tungsten(VI) chloride at 80℃; | A 44 % Chromat. B 9 % Chromat. C 4 % Chromat. |
With hydrogenchloride; dihydrogen peroxide at 80℃; | A 22 % Chromat. B 12 % Chromat. C 31 % Chromat. |
3,3,3-trifluoropropanal
A
3,3,3-trifluoropropanoyl chloride
B
3,3,3-Trifluoropropionic acid
C
3,3,3-trifluoro-2-chloropropionaldehyde
D
3,3,3-trifluoro-2-chloropropionyl chloride
E
2,2-dichloro-3,3,3-trifluoro-propionaldehyde
Conditions | Yield |
---|---|
With chlorine at 50℃; for 4h; Product distribution / selectivity; | |
With sulfuryl dichloride; dibenzoyl peroxide In water at 50℃; for 2.08333h; Product distribution / selectivity; | |
With sulfuryl dichloride; 2,2'-azobis(isobutyronitrile) In 2,4-dichloro-benzotrifluoride at 50℃; for 2.08333h; Product distribution / selectivity; |
3,3,3-trifluoropropanal
A
3,3,3-trifluoropropanoyl chloride
B
3,3,3-Trifluoropropionic acid
C
3,3,3-trifluoro-2-chloropropionaldehyde
D
3,3,3-trifluoro-2-chloropropionyl chloride
Conditions | Yield |
---|---|
With sulfuryl dichloride; dibenzoyl peroxide In 2,4-dichloro-benzotrifluoride; water at 50℃; for 2.08333h; Product distribution / selectivity; | |
With sulfuryl dichloride; 2,2'-azobis(isobutyronitrile) In 2,4-dichloro-benzotrifluoride at 50 - 65℃; for 2h; Product distribution / selectivity; | |
With trichloroisocyanuric acid In acetonitrile at 50℃; for 4.08333h; Product distribution / selectivity; |
3,3,3-trifluoropropanal
A
3,3,3-trifluoropropanoyl chloride
B
3,3,3-Trifluoropropionic acid
C
3,3,3-trifluoro-2-chloropropionaldehyde
D
2,2-dichloro-3,3,3-trifluoro-propionaldehyde
Conditions | Yield |
---|---|
With sulfuryl dichloride; 2,2'-azobis(isobutyronitrile) In acetonitrile at 50℃; for 4.08333h; Product distribution / selectivity; |
3,3,3-trifluoropropanal
A
3,3,3-trifluoropropanoyl chloride
B
3,3,3-Trifluoropropionic acid
C
3,3,3-trifluoro-2-chloropropionaldehyde
Conditions | Yield |
---|---|
With sulfuryl dichloride; 2,2'-azobis(isobutyronitrile) In toluene at 50℃; for 2.08333h; Product distribution / selectivity; |
3,3,3-trifluoropropanal
A
formic acid
B
Carbonyl fluoride
C
2,2,2-trifluoroethanol
D
2,2,2-Trifluoroacetaldehyde
E
3,3,3-Trifluoropropionic acid
Conditions | Yield |
---|---|
Quantum yield; Mechanism; Pressure; Photolysis; UV-irradiation; Air; |
S-(3,3,3-trifluoropropionyl)-N-acetylcysteamine
A
2-(acetylamino)ethanethiol
B
3,3,3-Trifluoropropionic acid
Conditions | Yield |
---|---|
With erythromycin thioesterase In dimethylsulfoxide-d6 pH=7.5; Kinetics; aq. buffer; Enzymatic reaction; |
3,3,3-Trifluoropropionic acid
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 10 - 35℃; | 100% |
3,3,3-Trifluoropropionic acid
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 10 - 35℃; | 100% |
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In tetrahydrofuran; N,N-dimethyl-formamide at 65℃; for 24h; | 100% |
3,3,3-Trifluoropropionic acid
3,3,3-trifluoropropanoyl chloride
Conditions | Yield |
---|---|
With phosphorus pentachloride at 65℃; Cooling with ice; | 99% |
With thionyl chloride; N,N-dimethyl-formamide at 70℃; for 4h; | 72% |
With Phthaloyl dichloride for 3h; Heating; | 69% |
Conditions | Yield |
---|---|
at 100℃; for 24h; Sealed tube; | 98% |
3,3,3-Trifluoropropionic acid
benzyl alcohol
benzyl 3,3,3-trifluoropropanoate
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide | 97% |
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 6h; Inert atmosphere; | 96% |
Stage #1: 3,3,3-Trifluoropropionic acid With oxalyl dichloride at 20 - 50℃; Stage #2: benzyl alcohol for 10h; | 94% |
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 2h; | 93% |
Conditions | Yield |
---|---|
With tert.-butylhydroperoxide In diethyl ether at 20℃; for 24h; | 96% |
methyl 4'-{[(3-aminopyridin-2-yl)amino]methyl}-biphenyl-2-carboxylate
3,3,3-Trifluoropropionic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride | 95% |
4'-[(3-amino-4-methyl-pyridin-2-ylamino)-methyl]-biphenyl-2-carboxylic acid methyl ester
3,3,3-Trifluoropropionic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride | 95% |
4'-[(R)-1-(3-Amino-4-methyl-pyridin-2-ylamino)-ethyl]-biphenyl-2-carboxylic acid methyl ester
3,3,3-Trifluoropropionic acid
Conditions | Yield |
---|---|
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride | 95% |
3,3,3-Trifluoropropionic acid
N,N-dimethyl-formamide
Conditions | Yield |
---|---|
Stage #1: N,N-dimethyl-formamide With oxalyl dichloride at 0℃; for 0.166667h; Inert atmosphere; Stage #2: 3,3,3-Trifluoropropionic acid at 0 - 70℃; for 1.16667h; | 95% |
With trichlorophosphate at 15 - 60℃; for 18h; Inert atmosphere; | 82% |
With trichlorophosphate at 60℃; for 16h; | 63.7% |
With phosgene at 0 - 70℃; for 1h; | |
With oxalyl dichloride at 70℃; for 1h; Inert atmosphere; |
3,3,3-Trifluoropropionic acid
(1R,2R,3S,5R)-2,6,6-trimethyl-2-(naphthalen-1-ylmethoxy)bicyclo[3.1.1]heptan-3-ol
(1R,2R,3S,5R)-2,6,6-trimethyl-2-(naphthalen-1-ylmethoxy)bicyclo[3.1.1]heptan-3-yl 3,3,3-trifluoropropanoate
Conditions | Yield |
---|---|
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 12h; Inert atmosphere; | 95% |
5-bromo-2-thiophencarboxaldehyde
3,3,3-Trifluoropropionic acid
C8H4BrF3O2S
Conditions | Yield |
---|---|
Stage #1: 5-bromo-2-thiophencarboxaldehyde; 3,3,3-Trifluoropropionic acid With titanium tetrachloride In tetrahydrofuran; dichloromethane at 20℃; for 0.5h; Stage #2: With triethylamine In tetrahydrofuran; dichloromethane at 20℃; for 40h; Knoevenagel condensation; Stage #3: With water In tetrahydrofuran; dichloromethane at 20℃; optical yield given as %de; stereoselective reaction; | 95% |
3,3,3-Trifluoropropionic acid
Conditions | Yield |
---|---|
In octane; benzene at 20℃; for 24h; | 95% |
3,3,3-Trifluoropropionic acid
(3S)-3-amino-1-(tert-butoxycarbonyl)-pyrrolidine
tert-butyl (3S)-3-[(3,3,3-trifluoropropanoyl)amino]pyrrolidine-1-carboxylate
Conditions | Yield |
---|---|
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine In dichloromethane; ethyl acetate at 0 - 20℃; for 1.5h; | 94% |
3,3,3-Trifluoropropionic acid
Conditions | Yield |
---|---|
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 12h; | 94% |
Conditions | Yield |
---|---|
In octane; benzene at 20℃; | 94% |
3,3,3-Trifluoropropionic acid
Conditions | Yield |
---|---|
Stage #1: 3,3,3-Trifluoropropionic acid; 1-(4-chlorophenyl)-2,2-difluoro-2-(4-nitrophenyl)ethan-1-ol With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 0.25h; Stage #2: With dmap In dichloromethane at 20℃; for 24h; | 93% |
1-hydroxy-pyrrolidine-2,5-dione
3,3,3-Trifluoropropionic acid
3,3,3-trifluoroacetic acid N-hydroxysuccinimide ester
Conditions | Yield |
---|---|
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; | 92% |
3,3,3-Trifluoropropionic acid
aniline
3,3,3-trifluoro-N-phenylpropionamide
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide In dichloromethane at 10 - 20℃; for 12h; | 92% |
Stage #1: 3,3,3-Trifluoropropionic acid With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; for 3h; Stage #2: aniline With triethylamine In dichloromethane; N,N-dimethyl-formamide at 0℃; | 92% |
Stage #1: 3,3,3-Trifluoropropionic acid With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 3h; Schlenk technique; Stage #2: aniline With triethylamine In dichloromethane; N,N-dimethyl-formamide at 0℃; Schlenk technique; |
3,3,3-Trifluoropropionic acid
N,N-dimethyl-formamide
N-[3-(dimethylamino)-2-(trifluoromethyl)-2-propenylidene]-N-dimethylammonium chloride
Conditions | Yield |
---|---|
With trichlorophosphate at 70℃; for 1h; | 91% |
With trichlorophosphate at 70℃; Inert atmosphere; | 74% |
Conditions | Yield |
---|---|
Stage #1: 3,3,3-Trifluoropropionic acid; benzaldehyde With titanium tetrachloride In tetrahydrofuran; dichloromethane at 20℃; for 0.5h; Stage #2: With triethylamine In tetrahydrofuran; dichloromethane at 20℃; for 40h; Knoevenagel condensation; Stage #3: With water In tetrahydrofuran; dichloromethane at 20℃; optical yield given as %de; stereoselective reaction; | 91% |
Stage #1: 3,3,3-Trifluoropropionic acid; benzaldehyde With titanium tetrachloride In tetrahydrofuran; dichloromethane at 20℃; for 0.5h; Stage #2: With triethylamine In tetrahydrofuran; dichloromethane for 40h; | 70% |
3,3,3-Trifluoropropionic acid
3-methoxy-2-hydroxybenzaldehyde
C11H7F3O3
Conditions | Yield |
---|---|
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine In acetic acid butyl ester; ethyl acetate at 120℃; Perkin condensation; | 91% |
Conditions | Yield |
---|---|
Stage #1: 3,3,3-Trifluoropropionic acid; 4-fluorobenzaldehyde With titanium tetrachloride In tetrahydrofuran; dichloromethane at 20℃; for 0.5h; Aldol Condensation; Stage #2: With triethylamine In tetrahydrofuran; dichloromethane at 20℃; for 24h; | 91% |
Conditions | Yield |
---|---|
In octane; benzene at 20℃; for 24h; | 91% |
3,3,3-Trifluoropropionic acid
4-bromo-benzaldehyde
(Z)-3-(4-bromophenyl)-2-(trifluoromethyl)acrylic acid
Conditions | Yield |
---|---|
Stage #1: 3,3,3-Trifluoropropionic acid; 4-bromo-benzaldehyde With titanium tetrachloride In tetrahydrofuran; dichloromethane at 20℃; for 0.5h; Stage #2: With triethylamine In tetrahydrofuran; dichloromethane at 20℃; for 40h; Knoevenagel condensation; Stage #3: With water In tetrahydrofuran; dichloromethane at 20℃; optical yield given as %de; stereoselective reaction; | 90% |
Stage #1: 3,3,3-Trifluoropropionic acid; 4-bromo-benzaldehyde With titanium tetrachloride In tetrahydrofuran; dichloromethane at -10℃; for 0.5h; Stage #2: With 4-methyl-morpholine In tetrahydrofuran; dichloromethane at 20℃; for 40h; Reagent/catalyst; Solvent; Temperature; regioselective reaction; | 69% |
Stage #1: 3,3,3-Trifluoropropionic acid; 4-bromo-benzaldehyde With titanium tetrachloride In tetrahydrofuran; dichloromethane at 20℃; for 0.5h; Stage #2: With triethylamine In tetrahydrofuran; dichloromethane for 40h; | 26% |
Stage #1: 3,3,3-Trifluoropropionic acid; 4-bromo-benzaldehyde With titanium tetrachloride In tetrahydrofuran; dichloromethane at 20℃; for 0.5h; Stage #2: With triethylamine for 40h; |
3,3,3-Trifluoropropionic acid
2-fluoro-4-chloroaniline
N-(4-chloro-2-fluoro-phenyl)-3,3,3-trifluoro-propionamide
Conditions | Yield |
---|---|
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane | 90% |
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane | 90% |
With triethylamine; HATU In dichloromethane |
Conditions | Yield |
---|---|
With dicyclohexyl-carbodiimide In dichloromethane at 10 - 20℃; for 12h; | 89% |
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