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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

3,3,3-Trifluoropropionic acid

Cas:2516-99-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

Factory supply 3,3,3-Trifluoropropionic acid CAS 2516-99-6 with fast delivery Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, F

Factory supply 3,3,3-Trifluoropropionic acid CAS 2516-99-6 with fast delivery

Cas:2516-99-6

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Jinan Finer Chemical Co., Ltd

Product description: Product name 3,3,3-Trifluoropropionic acid CAS number 2516-99-6 Assay ≥98% Appearance Colorless transparent liquid Capacity 200mt/year Application Pharma

3,3,3-Trifluoropropionic acid

Cas:2516-99-6

Min.Order:10 Gram

FOB Price: $12.0

Type:Lab/Research institutions

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:White or off-white Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

3,3,3-Trifluoropropionic Acid

Cas:2516-99-6

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3,3,3-Trifluoropropionic acid

Cas:2516-99-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Product Name: 3,3,3-Trifluoropropionic acid Synonyms: TFPA;RARECHEM AL BE 1046;3,3,3-TRIFLUOROPROPIONIC ACID;3,3,3-Trifluoropropionic acid 98%;3,3,3-Trifluoropropionicacid98%;3,3,3-TRIFLUOROPROPANOICACID;Trifluoromethylacetic acid;prop

2516-99-6 3,3,3-Trifluoropropionic acid

Cas:2516-99-6

Min.Order:1 Gram

FOB Price: $8900.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufactu

3,3,3-Trifluoropropanoic acid CAS 2516-99-6

Cas:2516-99-6

Min.Order:1 Kilogram

FOB Price: $1.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 2516-99-6 with fast shipping

Cas:2516-99-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

3,3,3-Trifluoropropionic acid

Cas:2516-99-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

3,3,3-Trifluoropropionic acid

Cas:2516-99-6

Min.Order:1 Kilogram

FOB Price: $1954.0 / 1989.0

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

3,3,3-Trifluoropropionic acid CAS:2516-99-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality orga

3,3,3-Trifluoropropionic acid CAS:2516-99-6

Cas:2516-99-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

3,3,3-Trifluoropropionic acid

Cas:2516-99-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:2516-99-6

Cas:2516-99-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou Fandachem Co.,Ltd

Hangzhou Fanda Chemical Co.,Ltd (FandaChem) , a China-based chemical company, specialize in exporting 3,3,3-Trifluoropropionic acid;TFPA cas 2516-99-6, Please contact us by email freely. We are leading exporter in China. If you

3,3,3-Trifluoropropionic acid;TFPA cas 2516-99-6 from FandaChem

Cas:2516-99-6

Min.Order:1 Metric Ton

Negotiable

Type:Other

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Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Protect packages from damage and keep them well closed. Store in a cool, well-ventilated, dry and shaded area. Avoid inhalation, ingestion and contact with eyes and ski

3,3,3-trifluoropropionic acid

Cas:2516-99-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Henan Kanbei Chemical Co.,LTD

1. Well-equipped, stable and high-quality raw material supply chain, to provide customers with the best quality products. 2.Strict quality inspection process and professional certificate testing to ensure the quality level of the final product. 3.E

hot sale 3,3,3-Trifluoropropionic acid

Cas:2516-99-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures

3,3,3-Trifluoropropanoic acid

Cas:2516-99-6

Min.Order:1 Kilogram

FOB Price: $16.0 / 20.0

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3,3,3-Trifluoropropionic acid

Cas:2516-99-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

3,3,3-trifluoropropanoic acid

Cas:2516-99-6

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 3,3,3-trifluoropropionic acid

Cas:2516-99-6

Min.Order:0 Metric Ton

Negotiable

Type:Other

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

3,3,3-Trifluoropropionic acid

Cas:2516-99-6

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

3,3,3-Trifluoropropionic Acid

Cas:2516-99-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality Appearance:Clear colorless liquid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used as Pharmaceutical Intermediates Transporta

3,3,3-Trifluoropropionic acid

Cas:2516-99-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Siwei Development Group Ltd.

Product name: 3,3,3-Trifluoropropionic Acid CAS No.:2516-99-6 Molecule Formula:C3H3F3O2 Molecule Weight:128.05 Purity: 98.0% Package: 25kg/drum Description:White or off-white powder Manufacture Standards:Enterprise Standard TESTI

High Quality 3,3,3-Trifluoropropionic Acid in stock

Cas:2516-99-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

3,3,3-Trifluoropropionic acid

Cas:2516-99-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Product Name: 3,3,3-Trifluoropropionic acid Synonyms: TFPA;RARECHEM AL BE 1046;Trifluoromethylacetic acid;3,3,3-TRIFLUOROPROPIONIC ACID;3,3,3-Trifluoropropionic acid 98%;3,3,3-Trifluoropropionicacid98%;3,3,3-TRIFLUOROPROPANOICACID;propanoic aci

3,3,3-Trifluoropropionic acid 2516-99-6 C3H3F3O2

Cas:2516-99-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

TIANFU CHEM 3,3,3-Trifluoropropionic acid

Cas:2516-99-6

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

3,3,3-Trifluoropropionic acid

Cas:2516-99-6

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

TIANFU CHEM 3,3,3-Trifluoropropionic acid

Cas:2516-99-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

TIANFU CHEM 3,3,3-Trifluoropropionic acid

Cas:2516-99-6

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

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Synthetic route

3,3,3-trifluoropropanal
460-40-2

3,3,3-trifluoropropanal

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

Conditions
ConditionsYield
With tetrabutoxytitanium; sodium molybdate; dihydrogen peroxide; calcium chloride In ethanol; water at 75 - 90℃; for 6h; Time; Inert atmosphere;96.1%
With nitric acid; sodium nitrite In water at 0 - 20℃; for 4h;61%
With sulfuric acid; sodium nitrite In water at 0 - 20℃; for 3h;61%
3,3,3-trifluoropropionyl fluoride
85345-75-1

3,3,3-trifluoropropionyl fluoride

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

Conditions
ConditionsYield
With water at 5 - 20℃; for 0.5h;93.4%
With water; sodium hydroxide at 5 - 20℃; for 0.5h;90.2%
methyl 3,3,3-trifluoropropionate
18830-44-9

methyl 3,3,3-trifluoropropionate

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

Conditions
ConditionsYield
With water; sodium hydroxide at 5 - 30℃; for 0.5h;88%
With hydrogen bromide80%
3,3,3-trifluoropropanoyl chloride
41463-83-6

3,3,3-trifluoropropanoyl chloride

3,3,3-trifluoro-2-chloropropionyl chloride
431-54-9

3,3,3-trifluoro-2-chloropropionyl chloride

A

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

B

2-chloro-3,3,3-trifluoropropanoic acid
110230-36-9

2-chloro-3,3,3-trifluoropropanoic acid

Conditions
ConditionsYield
With water at 50℃; for 4h; Product distribution / selectivity;A 84.5%
B n/a
3,3,3-trifluoropropanal
460-40-2

3,3,3-trifluoropropanal

A

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

B

3,3,3-trifluoro-1-(3,3,3-trifluoro-1-hydroxypropoxy)propan-1-ol
936107-87-8

3,3,3-trifluoro-1-(3,3,3-trifluoro-1-hydroxypropoxy)propan-1-ol

C

C9H9F9O3
936107-88-9

C9H9F9O3

Conditions
ConditionsYield
With water at -10 - 25℃; for 0.166667 - 168h; Product distribution / selectivity;A 0.06%
B 70.9%
C 0.2%
3,3,3-trifluoropropanoyl chloride
41463-83-6

3,3,3-trifluoropropanoyl chloride

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

Conditions
ConditionsYield
With water at 50℃; for 5h; Product distribution / selectivity;70.5%
3,3,3-trifluoropropanal
460-40-2

3,3,3-trifluoropropanal

A

3,3,3-trifluoropropanoyl chloride
41463-83-6

3,3,3-trifluoropropanoyl chloride

B

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

C

3,3,3-trifluoro-2-chloropropionyl chloride
431-54-9

3,3,3-trifluoro-2-chloropropionyl chloride

Conditions
ConditionsYield
With 2,2'-azobis(isobutyronitrile); chlorine In 2,4-dichloro-benzotrifluoride at 50℃; for 2.5h; Product distribution / selectivity;A 62.5%
B n/a
C n/a
ethyl 3,3,3-trifluoropropanoate
352-23-8

ethyl 3,3,3-trifluoropropanoate

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

Conditions
ConditionsYield
With sulfuric acid; water at 90℃; for 20h;61%
2-(2,2,2-trifluoroethylidene)-1,3-dithiane
122372-40-1

2-(2,2,2-trifluoroethylidene)-1,3-dithiane

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

Conditions
ConditionsYield
With sulfuric acid; mercury(II) oxide In tetrahydrofuran for 26h; Heating;60%
1-chloro-1,1,3,3,3-pentafluoropropane
460-92-4

1-chloro-1,1,3,3,3-pentafluoropropane

1,1-dichloro-1,3,3,3-tetrafluoropropane
64712-27-2

1,1-dichloro-1,3,3,3-tetrafluoropropane

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

Conditions
ConditionsYield
Stage #1: 1-chloro-1,1,3,3,3-pentafluoropropane; 1,1-dichloro-1,3,3,3-tetrafluoropropane With sulfuric acid; sulfur trioxide at 100 - 125℃; for 19 - 30h;
Stage #2: With water at 20℃; Product distribution / selectivity;
22%
3,3,3-Trifluoropropanol
2240-88-2

3,3,3-Trifluoropropanol

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

Conditions
ConditionsYield
With sodium dichromate; sulfuric acid
3,3,3-Trifluorpropionylschwefelsaeure

3,3,3-Trifluorpropionylschwefelsaeure

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

Conditions
ConditionsYield
With water
trifluoromethyl-malonic acid dinitrile
10472-02-3

trifluoromethyl-malonic acid dinitrile

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

Conditions
ConditionsYield
With hydrogenchloride
1,1,1-tribromotrifluoroethane
354-48-3

1,1,1-tribromotrifluoroethane

carbon dioxide
124-38-9

carbon dioxide

A

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

B

2-bromo-3,3,3-trifluoropropanoic acid

2-bromo-3,3,3-trifluoropropanoic acid

Conditions
ConditionsYield
With water; hydrogen cation; zinc In N,N-dimethyl-formamide for 6h; irradiated by ultrasound;A 0.1 % Spectr.
B 1.0 % Spectr.
perfluoroisobutylene
382-21-8

perfluoroisobutylene

A

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

B

3,3,3-trifluoro-2-(trifluoromethyl)propanoic acid
564-10-3

3,3,3-trifluoro-2-(trifluoromethyl)propanoic acid

C

1-(trifluoromethylthio)-perfluoro-2-(trifluoromethyl)-propene

1-(trifluoromethylthio)-perfluoro-2-(trifluoromethyl)-propene

D

1-(trifluoromethylthio)-2H, 2-(trifluoromethylthiodifluoromethyl)-perfluoropropene

1-(trifluoromethylthio)-2H, 2-(trifluoromethylthiodifluoromethyl)-perfluoropropene

Conditions
ConditionsYield
With moisture; Copper(I) trifluoromethanethiolate In acetonitrile 1.) -78 deg C, 2 h, 2.) from 55 deg C to 60 deg C, 4 h; Further byproducts given. Title compound not separated from byproducts;
perfluoroisobutylene
382-21-8

perfluoroisobutylene

A

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

B

2,2,3,3-tetra(trifluoromethyl)-perfluorobutane
39902-62-0

2,2,3,3-tetra(trifluoromethyl)-perfluorobutane

C

1-(trifluoromethylthio)-perfluoro-2-(trifluoromethyl)-propene

1-(trifluoromethylthio)-perfluoro-2-(trifluoromethyl)-propene

D

1-(trifluoromethylthio)-2H, 2-(trifluoromethylthiodifluoromethyl)-perfluoropropene

1-(trifluoromethylthio)-2H, 2-(trifluoromethylthiodifluoromethyl)-perfluoropropene

Conditions
ConditionsYield
With moisture; Copper(I) trifluoromethanethiolate In acetonitrile 1.) -78 deg C, 2 h, 2.) from 55 deg C to 60 deg C, 4 h; Further byproducts given. Title compound not separated from byproducts;
trifluoromethylketene
134736-46-2

trifluoromethylketene

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

Conditions
ConditionsYield
With water Rate constant;
cyclohexyl trifluoropropionate

cyclohexyl trifluoropropionate

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

Conditions
ConditionsYield
With trimethylsilyl iodide In chloroform at 65℃; for 9h;1.7 g
iodotrifluoromethane
2314-97-8

iodotrifluoromethane

1-(tert-butyldimethylsilyloxy)-1-tert-butoxyethylene
74786-02-0

1-(tert-butyldimethylsilyloxy)-1-tert-butoxyethylene

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

Conditions
ConditionsYield
With triethyl borane; oxonium 1.) hexane, RT, 2h, 2.) RT, 15 h; Yield given. Multistep reaction;
3,3,3-trifluoroprop-1-yne
661-54-1

3,3,3-trifluoroprop-1-yne

sulfuric acid
7664-93-9

sulfuric acid

mercury(II) sulfate

mercury(II) sulfate

A

trifluoromethan
75-46-7

trifluoromethan

B

1,1,1-trifluoro-2-propanone
421-50-1

1,1,1-trifluoro-2-propanone

C

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

D

methylammonium carbonate
15719-64-9, 15719-76-3, 97762-63-5

methylammonium carbonate

Conditions
ConditionsYield
at 135℃;
1,1,1-trifluoro-3-diazo-2-oxopropane
433-26-1

1,1,1-trifluoro-3-diazo-2-oxopropane

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

Conditions
ConditionsYield
In diethyl ether for 0.25h; Photolysis;
3,3,3-trifluoropropanal dimethyl acetal
116586-94-8

3,3,3-trifluoropropanal dimethyl acetal

A

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

B

methyl 3,3,3-trifluoropropionate
18830-44-9

methyl 3,3,3-trifluoropropionate

Conditions
ConditionsYield
With hydrogenchloride; dihydrogen peroxide; iron(III) chloride at 80℃; for 1h;A 95 % Chromat.
B 3 % Chromat.
3,3,3-trifluoropropanal dimethyl acetal
116586-94-8

3,3,3-trifluoropropanal dimethyl acetal

A

3,3,3-trifluoropropanal
460-40-2

3,3,3-trifluoropropanal

B

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

C

methyl 3,3,3-trifluoropropionate
18830-44-9

methyl 3,3,3-trifluoropropionate

Conditions
ConditionsYield
With copper(I) oxide; hydrogenchloride; dihydrogen peroxide at 80℃;A 2 % Chromat.
B 91 % Chromat.
C 7 % Chromat.
With hydrogenchloride; dihydrogen peroxide; tungsten(VI) chloride at 80℃;A 44 % Chromat.
B 9 % Chromat.
C 4 % Chromat.
With hydrogenchloride; dihydrogen peroxide at 80℃;A 22 % Chromat.
B 12 % Chromat.
C 31 % Chromat.
3,3,3-trifluoropropanal
460-40-2

3,3,3-trifluoropropanal

A

3,3,3-trifluoropropanoyl chloride
41463-83-6

3,3,3-trifluoropropanoyl chloride

B

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

C

3,3,3-trifluoro-2-chloropropionaldehyde
19256-25-8

3,3,3-trifluoro-2-chloropropionaldehyde

D

3,3,3-trifluoro-2-chloropropionyl chloride
431-54-9

3,3,3-trifluoro-2-chloropropionyl chloride

E

2,2-dichloro-3,3,3-trifluoro-propionaldehyde
82107-24-2

2,2-dichloro-3,3,3-trifluoro-propionaldehyde

Conditions
ConditionsYield
With chlorine at 50℃; for 4h; Product distribution / selectivity;
With sulfuryl dichloride; dibenzoyl peroxide In water at 50℃; for 2.08333h; Product distribution / selectivity;
With sulfuryl dichloride; 2,2'-azobis(isobutyronitrile) In 2,4-dichloro-benzotrifluoride at 50℃; for 2.08333h; Product distribution / selectivity;
3,3,3-trifluoropropanal
460-40-2

3,3,3-trifluoropropanal

A

3,3,3-trifluoropropanoyl chloride
41463-83-6

3,3,3-trifluoropropanoyl chloride

B

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

C

3,3,3-trifluoro-2-chloropropionaldehyde
19256-25-8

3,3,3-trifluoro-2-chloropropionaldehyde

D

3,3,3-trifluoro-2-chloropropionyl chloride
431-54-9

3,3,3-trifluoro-2-chloropropionyl chloride

Conditions
ConditionsYield
With sulfuryl dichloride; dibenzoyl peroxide In 2,4-dichloro-benzotrifluoride; water at 50℃; for 2.08333h; Product distribution / selectivity;
With sulfuryl dichloride; 2,2'-azobis(isobutyronitrile) In 2,4-dichloro-benzotrifluoride at 50 - 65℃; for 2h; Product distribution / selectivity;
With trichloroisocyanuric acid In acetonitrile at 50℃; for 4.08333h; Product distribution / selectivity;
3,3,3-trifluoropropanal
460-40-2

3,3,3-trifluoropropanal

A

3,3,3-trifluoropropanoyl chloride
41463-83-6

3,3,3-trifluoropropanoyl chloride

B

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

C

3,3,3-trifluoro-2-chloropropionaldehyde
19256-25-8

3,3,3-trifluoro-2-chloropropionaldehyde

D

2,2-dichloro-3,3,3-trifluoro-propionaldehyde
82107-24-2

2,2-dichloro-3,3,3-trifluoro-propionaldehyde

Conditions
ConditionsYield
With sulfuryl dichloride; 2,2'-azobis(isobutyronitrile) In acetonitrile at 50℃; for 4.08333h; Product distribution / selectivity;
3,3,3-trifluoropropanal
460-40-2

3,3,3-trifluoropropanal

A

3,3,3-trifluoropropanoyl chloride
41463-83-6

3,3,3-trifluoropropanoyl chloride

B

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

C

3,3,3-trifluoro-2-chloropropionaldehyde
19256-25-8

3,3,3-trifluoro-2-chloropropionaldehyde

Conditions
ConditionsYield
With sulfuryl dichloride; 2,2'-azobis(isobutyronitrile) In toluene at 50℃; for 2.08333h; Product distribution / selectivity;
3,3,3-trifluoropropanal
460-40-2

3,3,3-trifluoropropanal

A

formic acid
64-18-6

formic acid

B

Carbonyl fluoride
353-50-4

Carbonyl fluoride

C

2,2,2-trifluoroethanol
75-89-8

2,2,2-trifluoroethanol

D

2,2,2-Trifluoroacetaldehyde
75-90-1

2,2,2-Trifluoroacetaldehyde

E

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

Conditions
ConditionsYield
Quantum yield; Mechanism; Pressure; Photolysis; UV-irradiation; Air;
S-(3,3,3-trifluoropropionyl)-N-acetylcysteamine
1402718-98-2

S-(3,3,3-trifluoropropionyl)-N-acetylcysteamine

A

2-(acetylamino)ethanethiol
1190-73-4

2-(acetylamino)ethanethiol

B

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

Conditions
ConditionsYield
With erythromycin thioesterase In dimethylsulfoxide-d6 pH=7.5; Kinetics; aq. buffer; Enzymatic reaction;
3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

(2R)-2-amino-N-(4-(tert-butyl)-3-chlorophenyl)-2-(tetrahydro-2H-pyran-4-yl)acetamide hydrochloride

(2R)-2-amino-N-(4-(tert-butyl)-3-chlorophenyl)-2-(tetrahydro-2H-pyran-4-yl)acetamide hydrochloride

N-((1R)-2-((4-tert-butyl-3-chlorophenyl)amino)-2-oxo-1-(tetrahydro-2H-pyran-4-yl)ethyl)-3,3,3-trifluoropropanamide

N-((1R)-2-((4-tert-butyl-3-chlorophenyl)amino)-2-oxo-1-(tetrahydro-2H-pyran-4-yl)ethyl)-3,3,3-trifluoropropanamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 10 - 35℃;100%
3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

(2R)-2-amino-N-(4-(tert-butyl)-3-chlorophenyl)-2-(tetrahydro-2H-pyran-4-yl)acetamide hydrochloride

(2R)-2-amino-N-(4-(tert-butyl)-3-chlorophenyl)-2-(tetrahydro-2H-pyran-4-yl)acetamide hydrochloride

N-((1R)-2-((4-tert-butyl-3-chlorophenyl)amino)-2-oxo-1-(tetrahydro-2H-pyran-4-yl)ethyl)-3,3,3-trifluoro-2-hydroxypropanamide

N-((1R)-2-((4-tert-butyl-3-chlorophenyl)amino)-2-oxo-1-(tetrahydro-2H-pyran-4-yl)ethyl)-3,3,3-trifluoro-2-hydroxypropanamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 10 - 35℃;100%
morpholine
110-91-8

morpholine

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

3,3,3-trifluoropropanoic acid morpholide

3,3,3-trifluoropropanoic acid morpholide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In tetrahydrofuran; N,N-dimethyl-formamide at 65℃; for 24h;100%
3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

3,3,3-trifluoropropanoyl chloride
41463-83-6

3,3,3-trifluoropropanoyl chloride

Conditions
ConditionsYield
With phosphorus pentachloride at 65℃; Cooling with ice;99%
With thionyl chloride; N,N-dimethyl-formamide at 70℃; for 4h;72%
With Phthaloyl dichloride for 3h; Heating;69%
3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

C15H17N3

C15H17N3

water
7732-18-5

water

silver(I) 4-chlorobenzoate
72247-98-4

silver(I) 4-chlorobenzoate

cobalt(II) bromide

cobalt(II) bromide

C22H20ClCoN3O2(1+)*H2O*C3H3F3O2*C7H4ClO2(1-)

C22H20ClCoN3O2(1+)*H2O*C3H3F3O2*C7H4ClO2(1-)

Conditions
ConditionsYield
at 100℃; for 24h; Sealed tube;98%
3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

benzyl alcohol
100-51-6

benzyl alcohol

benzyl 3,3,3-trifluoropropanoate
78686-91-6

benzyl 3,3,3-trifluoropropanoate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide97%
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 6h; Inert atmosphere;96%
Stage #1: 3,3,3-Trifluoropropionic acid With oxalyl dichloride at 20 - 50℃;
Stage #2: benzyl alcohol for 10h;
94%
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 2h;93%
3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

triphenylantimony
603-36-1

triphenylantimony

μ2-oxobis(3,3,3-trifluoropropanatotriphenylantimony)

μ2-oxobis(3,3,3-trifluoropropanatotriphenylantimony)

Conditions
ConditionsYield
With tert.-butylhydroperoxide In diethyl ether at 20℃; for 24h;96%
methyl 4'-{[(3-aminopyridin-2-yl)amino]methyl}-biphenyl-2-carboxylate
661485-12-7

methyl 4'-{[(3-aminopyridin-2-yl)amino]methyl}-biphenyl-2-carboxylate

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

4'-{[3-(3,3,3-trifluoro-propionylamino)-pyridin-2-ylamino]-methyl}-biphenyl-2-carboxylic acid methyl ester

4'-{[3-(3,3,3-trifluoro-propionylamino)-pyridin-2-ylamino]-methyl}-biphenyl-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride95%
4'-[(3-amino-4-methyl-pyridin-2-ylamino)-methyl]-biphenyl-2-carboxylic acid methyl ester
851901-72-9

4'-[(3-amino-4-methyl-pyridin-2-ylamino)-methyl]-biphenyl-2-carboxylic acid methyl ester

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

4'-{[4-methyl-3-(3,3,3-trifluoro-propionylamino)-pyridin-2-ylamino]-methyl}-biphenyl-2-carboxylic acid methyl ester

4'-{[4-methyl-3-(3,3,3-trifluoro-propionylamino)-pyridin-2-ylamino]-methyl}-biphenyl-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride95%
4'-[(R)-1-(3-Amino-4-methyl-pyridin-2-ylamino)-ethyl]-biphenyl-2-carboxylic acid methyl ester
851901-73-0

4'-[(R)-1-(3-Amino-4-methyl-pyridin-2-ylamino)-ethyl]-biphenyl-2-carboxylic acid methyl ester

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

4'-{(R)-1-[4-Methyl-3-(3,3,3-trifluoro-propionylamino)-pyridin-2-ylamino]-ethyl}-biphenyl-2-carboxylic acid methyl ester

4'-{(R)-1-[4-Methyl-3-(3,3,3-trifluoro-propionylamino)-pyridin-2-ylamino]-ethyl}-biphenyl-2-carboxylic acid methyl ester

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride95%
3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

(Z)-N-(3-(dimethylamino)-2-(trifluoromethyl)allylidene)-N-methylmethanaminium chloride salt

(Z)-N-(3-(dimethylamino)-2-(trifluoromethyl)allylidene)-N-methylmethanaminium chloride salt

Conditions
ConditionsYield
Stage #1: N,N-dimethyl-formamide With oxalyl dichloride at 0℃; for 0.166667h; Inert atmosphere;
Stage #2: 3,3,3-Trifluoropropionic acid at 0 - 70℃; for 1.16667h;
95%
With trichlorophosphate at 15 - 60℃; for 18h; Inert atmosphere;82%
With trichlorophosphate at 60℃; for 16h;63.7%
With phosgene at 0 - 70℃; for 1h;
With oxalyl dichloride at 70℃; for 1h; Inert atmosphere;
3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

(1R,2R,3S,5R)-2,6,6-trimethyl-2-(naphthalen-1-ylmethoxy)bicyclo[3.1.1]heptan-3-ol
1338323-37-7

(1R,2R,3S,5R)-2,6,6-trimethyl-2-(naphthalen-1-ylmethoxy)bicyclo[3.1.1]heptan-3-ol

(1R,2R,3S,5R)-2,6,6-trimethyl-2-(naphthalen-1-ylmethoxy)bicyclo[3.1.1]heptan-3-yl 3,3,3-trifluoropropanoate
1338323-42-4

(1R,2R,3S,5R)-2,6,6-trimethyl-2-(naphthalen-1-ylmethoxy)bicyclo[3.1.1]heptan-3-yl 3,3,3-trifluoropropanoate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 12h; Inert atmosphere;95%
5-bromo-2-thiophencarboxaldehyde
4701-17-1

5-bromo-2-thiophencarboxaldehyde

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

C8H4BrF3O2S
1352743-46-4

C8H4BrF3O2S

Conditions
ConditionsYield
Stage #1: 5-bromo-2-thiophencarboxaldehyde; 3,3,3-Trifluoropropionic acid With titanium tetrachloride In tetrahydrofuran; dichloromethane at 20℃; for 0.5h;
Stage #2: With triethylamine In tetrahydrofuran; dichloromethane at 20℃; for 40h; Knoevenagel condensation;
Stage #3: With water In tetrahydrofuran; dichloromethane at 20℃; optical yield given as %de; stereoselective reaction;
95%
3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

tetraphenylantimony 3,3,3-trifluoropropanate

tetraphenylantimony 3,3,3-trifluoropropanate

1 : 1 solvate of tetraphenylantimony 3,3,3-trifluoropropanate with 3,3,3-trifluoropropanoic acid

1 : 1 solvate of tetraphenylantimony 3,3,3-trifluoropropanate with 3,3,3-trifluoropropanoic acid

Conditions
ConditionsYield
In octane; benzene at 20℃; for 24h;95%
3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

(3S)-3-amino-1-(tert-butoxycarbonyl)-pyrrolidine
147081-44-5

(3S)-3-amino-1-(tert-butoxycarbonyl)-pyrrolidine

tert-butyl (3S)-3-[(3,3,3-trifluoropropanoyl)amino]pyrrolidine-1-carboxylate
891944-04-0

tert-butyl (3S)-3-[(3,3,3-trifluoropropanoyl)amino]pyrrolidine-1-carboxylate

Conditions
ConditionsYield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine In dichloromethane; ethyl acetate at 0 - 20℃; for 1.5h;94%
3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

7-(3-chloro-4-methoxyphenyl)-9-methoxy-2,3,4,5-tetrahydro-1,4-benzoxazepine

7-(3-chloro-4-methoxyphenyl)-9-methoxy-2,3,4,5-tetrahydro-1,4-benzoxazepine

1-[7-(3-chloro-4-methoxyphenyl)-9-methoxy-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl]-3,3,3-trifluoropropan-1-one

1-[7-(3-chloro-4-methoxyphenyl)-9-methoxy-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl]-3,3,3-trifluoropropan-1-one

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 12h;94%
3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

pentaphenylantimony
2170-05-0

pentaphenylantimony

tetraphenylantimony 3,3,3-trifluoropropanate

tetraphenylantimony 3,3,3-trifluoropropanate

Conditions
ConditionsYield
In octane; benzene at 20℃;94%
3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

1-(4-chlorophenyl)-2,2-difluoro-2-(4-nitrophenyl)ethan-1-ol

1-(4-chlorophenyl)-2,2-difluoro-2-(4-nitrophenyl)ethan-1-ol

1-(4-chlorophenyl)-2,2-difluoro-2-(4-nitrophenyl)-ethyl 3,3,3-trifluoropropanoate

1-(4-chlorophenyl)-2,2-difluoro-2-(4-nitrophenyl)-ethyl 3,3,3-trifluoropropanoate

Conditions
ConditionsYield
Stage #1: 3,3,3-Trifluoropropionic acid; 1-(4-chlorophenyl)-2,2-difluoro-2-(4-nitrophenyl)ethan-1-ol With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 0.25h;
Stage #2: With dmap In dichloromethane at 20℃; for 24h;
93%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

3,3,3-trifluoroacetic acid N-hydroxysuccinimide ester
405878-89-9

3,3,3-trifluoroacetic acid N-hydroxysuccinimide ester

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃;92%
3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

aniline
62-53-3

aniline

3,3,3-trifluoro-N-phenylpropionamide
351-12-2

3,3,3-trifluoro-N-phenylpropionamide

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane at 10 - 20℃; for 12h;92%
Stage #1: 3,3,3-Trifluoropropionic acid With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; for 3h;
Stage #2: aniline With triethylamine In dichloromethane; N,N-dimethyl-formamide at 0℃;
92%
Stage #1: 3,3,3-Trifluoropropionic acid With oxalyl dichloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 3h; Schlenk technique;
Stage #2: aniline With triethylamine In dichloromethane; N,N-dimethyl-formamide at 0℃; Schlenk technique;
3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

N-[3-(dimethylamino)-2-(trifluoromethyl)-2-propenylidene]-N-dimethylammonium chloride
176214-18-9

N-[3-(dimethylamino)-2-(trifluoromethyl)-2-propenylidene]-N-dimethylammonium chloride

Conditions
ConditionsYield
With trichlorophosphate at 70℃; for 1h;91%
With trichlorophosphate at 70℃; Inert atmosphere;74%
3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

benzaldehyde
100-52-7

benzaldehyde

(Z)-3-phenyl-2-(trifluoromethyl)acrylic acid

(Z)-3-phenyl-2-(trifluoromethyl)acrylic acid

Conditions
ConditionsYield
Stage #1: 3,3,3-Trifluoropropionic acid; benzaldehyde With titanium tetrachloride In tetrahydrofuran; dichloromethane at 20℃; for 0.5h;
Stage #2: With triethylamine In tetrahydrofuran; dichloromethane at 20℃; for 40h; Knoevenagel condensation;
Stage #3: With water In tetrahydrofuran; dichloromethane at 20℃; optical yield given as %de; stereoselective reaction;
91%
Stage #1: 3,3,3-Trifluoropropionic acid; benzaldehyde With titanium tetrachloride In tetrahydrofuran; dichloromethane at 20℃; for 0.5h;
Stage #2: With triethylamine In tetrahydrofuran; dichloromethane for 40h;
70%
3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

3-methoxy-2-hydroxybenzaldehyde
148-53-8

3-methoxy-2-hydroxybenzaldehyde

C11H7F3O3
1392849-00-1

C11H7F3O3

Conditions
ConditionsYield
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine In acetic acid butyl ester; ethyl acetate at 120℃; Perkin condensation;91%
3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

3-(4-fluorophenyl)-2-(trifluoromethyl)acrylic acid

3-(4-fluorophenyl)-2-(trifluoromethyl)acrylic acid

Conditions
ConditionsYield
Stage #1: 3,3,3-Trifluoropropionic acid; 4-fluorobenzaldehyde With titanium tetrachloride In tetrahydrofuran; dichloromethane at 20℃; for 0.5h; Aldol Condensation;
Stage #2: With triethylamine In tetrahydrofuran; dichloromethane at 20℃; for 24h;
91%
3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

pentaphenylantimony
2170-05-0

pentaphenylantimony

1 : 1 solvate of tetraphenylantimony 3,3,3-trifluoropropanate with 3,3,3-trifluoropropanoic acid

1 : 1 solvate of tetraphenylantimony 3,3,3-trifluoropropanate with 3,3,3-trifluoropropanoic acid

Conditions
ConditionsYield
In octane; benzene at 20℃; for 24h;91%
3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

4-bromo-benzaldehyde
1122-91-4

4-bromo-benzaldehyde

(Z)-3-(4-bromophenyl)-2-(trifluoromethyl)acrylic acid
1321619-38-8

(Z)-3-(4-bromophenyl)-2-(trifluoromethyl)acrylic acid

Conditions
ConditionsYield
Stage #1: 3,3,3-Trifluoropropionic acid; 4-bromo-benzaldehyde With titanium tetrachloride In tetrahydrofuran; dichloromethane at 20℃; for 0.5h;
Stage #2: With triethylamine In tetrahydrofuran; dichloromethane at 20℃; for 40h; Knoevenagel condensation;
Stage #3: With water In tetrahydrofuran; dichloromethane at 20℃; optical yield given as %de; stereoselective reaction;
90%
Stage #1: 3,3,3-Trifluoropropionic acid; 4-bromo-benzaldehyde With titanium tetrachloride In tetrahydrofuran; dichloromethane at -10℃; for 0.5h;
Stage #2: With 4-methyl-morpholine In tetrahydrofuran; dichloromethane at 20℃; for 40h; Reagent/catalyst; Solvent; Temperature; regioselective reaction;
69%
Stage #1: 3,3,3-Trifluoropropionic acid; 4-bromo-benzaldehyde With titanium tetrachloride In tetrahydrofuran; dichloromethane at 20℃; for 0.5h;
Stage #2: With triethylamine In tetrahydrofuran; dichloromethane for 40h;
26%
Stage #1: 3,3,3-Trifluoropropionic acid; 4-bromo-benzaldehyde With titanium tetrachloride In tetrahydrofuran; dichloromethane at 20℃; for 0.5h;
Stage #2: With triethylamine for 40h;
3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

2-fluoro-4-chloroaniline
57946-56-2

2-fluoro-4-chloroaniline

N-(4-chloro-2-fluoro-phenyl)-3,3,3-trifluoro-propionamide
1538626-78-6

N-(4-chloro-2-fluoro-phenyl)-3,3,3-trifluoro-propionamide

Conditions
ConditionsYield
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane90%
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane90%
With triethylamine; HATU In dichloromethane
3,3,3-Trifluoropropionic acid
2516-99-6

3,3,3-Trifluoropropionic acid

4-fluoroaniline
371-40-4

4-fluoroaniline

3,3,3-trifluoro-N-(4-fluorophenyl)propanamide

3,3,3-trifluoro-N-(4-fluorophenyl)propanamide

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In dichloromethane at 10 - 20℃; for 12h;89%

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