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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

METHYL 4-ETHYNYLBENZOATE

Cas:3034-86-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Product Name: 4-ETHYNYL-BENZOIC ACID METHYL ESTER Synonyms: Methyl-4-Ethylnylbenzoate;Methyl p-ethynylbenzoate;p-Ethynylbenzoic acid methyl ester;Benzoic acid,4-ethynyl-, Methyl ester;Methyl 4-ethynylbenzoate 95%;EOS-62181;4-ETHYNYL-BENZOIC ACID M

4-ETHYNYL-BENZOIC ACID METHYL ESTER 3034-86-4

Cas:3034-86-4

Min.Order:1 Kilogram

FOB Price: $200.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 3034-86-4 with best quality

Cas:3034-86-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

Benzoic acid,4-ethynyl-, methyl ester

Cas:3034-86-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

4-ETHYNYL-BENZOIC ACID METHYL ESTER CAS:3034-86-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quali

4-ETHYNYL-BENZOIC ACID METHYL ESTER CAS:3034-86-4

Cas:3034-86-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:3034-86-4

Cas:3034-86-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Benzoic acid,4-ethynyl-, methyl ester

Cas:3034-86-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shanghai Massive Chemical Technology Co., Ltd.

Massive Chemical is certified with ISO9001 and ISO14001 manufacturer for this product. We will offer all documents as requirement for the materials which includes, Certificate of Analysis, Material Safety Data Sheet, and Method of Analysis and

4-ETHYNYL-BENZOIC ACID METHYL ESTER/High quality/Best price

Cas:3034-86-4

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Methyl 4-ethynylbenzoate CAS NO.3034-86-4

Cas:3034-86-4

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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HANGZHOU YUNUO CHEMICAL CO.,LTD

superior quality moderate price & quick delivery Appearance:powder Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:1kg/bag, 1kg/drum or 25kg/drum or as per your request. Application:Used to make other chemica

Benzoic acid,4-ethynyl-, methyl ester

Cas:3034-86-4

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

4-ETHYNYL-BENZOIC ACID METHYL ESTER

Cas:3034-86-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

4-ETHYNYL-BENZOIC ACID METHYL ESTER

Cas:3034-86-4

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

4-ETHYNYL-BENZOIC ACID METHYL ESTER

Cas:3034-86-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

Methyl 4-ethynylbenzoate

Cas:3034-86-4

Min.Order:1 Kilogram

Negotiable

Type:Other

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Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

Methyl 4-ethynylbenzoate cas no. 3034-86-4 98%

Cas:3034-86-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Greenutra Resource Inc

methyl 4-ethynylbenzoateAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air

methyl 4-ethynylbenzoate

Cas:3034-86-4

Min.Order:0

Negotiable

Type:Trading Company

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Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

methyl 4-ethynylbenzoate

Cas:3034-86-4

Min.Order:0

Negotiable

Type:Other

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Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec Methyl 4-ethynylbenzoate 100g

Cas:3034-86-4

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

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Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd a comprehensive enterprise, is located in High-Tech Science Park,Changsha,Chia . Specializing in R&D, manufacture and marketing, we provide a wide range of products and the most professional services to meet the

6-Chloro-2-fluoropurine

Cas:3034-86-4

Min.Order:0

Negotiable

Type:Manufacturers

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Shanghai Finebiotech Co.,Ltd.

Shanghai Finebiotech Co.,Ltd.was established in 2020, which providing professional chemical services. As a customer-oriented company, we have distinguished ourself from others in providing worldwide customers with cost-effective and efficient service

Methyl 4-ethynylbenzoate

Cas:3034-86-4

Min.Order:0

Negotiable

Type:Trading Company

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Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

Methyl 4-ethynylbenzoate

Cas:3034-86-4

Min.Order:0

Negotiable

Type:Manufacturers

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Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Benzoic acid,4-ethynyl-, Methyl ester

Cas:3034-86-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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HANGZHOU TIANYE CHEMICALS CO., LTD.

"HANGZHOU TIANYE CHEMICALS Co.LTD , Located in Eastern Science and Innovation Park Hangzhou .We are a high-tech enterprise specialized in technical research and development, production, development and trade of chemical products. We supply Multiple s

methyl 4-ethynylbenzoate

Cas:3034-86-4

Min.Order:0

Negotiable

Type:Trading Company

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Hangzhou Fandachem Co.,Ltd

Benzoic acid,4-ethynyl-, methyl esterAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:pharmaceutical intermediate Transportation:by air, by sea, by express

Benzoic acid,4-ethynyl-, methyl ester

Cas:3034-86-4

Min.Order:0

Negotiable

Type:Other

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Hunan Longxianng Runhui Trading Co.,Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

4-ETHYNYL-BENZOIC ACID METHYL ESTER

Cas:3034-86-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shanghai Yuanye Bio-Technology Co., Ltd.

good quality, competitive price, thoughtful after sale serviceAppearance:white powder Storage:Keep it in dry,shady and cool place Package:250mg Application:Pharma;Industry;Agricultural;chemical reaserch Transportation:by express or by sea Port:Any po

4-Ethynyl-Benzoic Acid Methyl Ester

Cas:3034-86-4

Min.Order:0

Negotiable

Type:Trading Company

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Chemlyte Solutions

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

methyl 4-ethynylbenzoate

Cas:3034-86-4

Min.Order:0

Negotiable

Type:Other

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Shanghai Puhao Chemical Technology Co. Ltd.

Our company's tenet is to treat every customer sincerely and be responsible for every product. The production of products according to customer demand for customized, in strict accordance with strict requirements, the production of products alw

Buy High purity of 4-ETHYNYL-BENZOIC ACID METHYL ESTER

Cas:3034-86-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Trading Company

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Hunan Russell Chemicals Technology Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

Methyl 4-ethynylbenzoate 3034-86-4

Cas:3034-86-4

Min.Order:0

Negotiable

Type:Trading Company

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Chemsigma International Co.,Ltd.

bulk?production Application:Pharmaceutical intermediates

4-ETHYNYL-BENZOIC ACID METHYL ESTER

Cas:3034-86-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Synthetic route

methyl 4-(3-hydroxy-3-methylbut-1-ynyl)benzoate
33577-98-9

methyl 4-(3-hydroxy-3-methylbut-1-ynyl)benzoate

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

Conditions
ConditionsYield
With potassium phosphate; potassium hydroxide In toluene for 0.0833333h; Reagent/catalyst; Time; Inert atmosphere; Reflux;100%
With sodium hydride In toluene at 110℃;98%
With potassium phosphate; potassium carbonate In toluene Inert atmosphere;92%
4-trimethylsilanylethynyl-benzoic acid methyl ester
75867-41-3

4-trimethylsilanylethynyl-benzoic acid methyl ester

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

Conditions
ConditionsYield
With potassium carbonate In methanol for 2h;100%
With tetrabutyl ammonium fluoride In tetrahydrofuran at -20℃; for 0.5h;99%
With potassium carbonate In methanol; dichloromethane99%
(Z)-4-(β-bromovinyl)benzoic acid methyl ester
356759-39-2

(Z)-4-(β-bromovinyl)benzoic acid methyl ester

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide for 1h; microwave irradiation;99%
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide for 0.0166667h; microwave irradiation;
With sodium ethanolate In N,N-dimethyl-formamide at 120℃; for 12h;
methanol
67-56-1

methanol

ethyl 4-(trimethylsilylethynyl)benzoate
150969-54-3

ethyl 4-(trimethylsilylethynyl)benzoate

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

Conditions
ConditionsYield
With potassium carbonate at 20℃; for 2h;99%
With potassium carbonate at 20℃; for 0.5h;91%
With potassium carbonate at 20℃; for 2h;90%
With potassium carbonate at 10 - 20℃; for 3.86667h; Inert atmosphere; Schlenk technique;12.3 g
methyl 4-acetylbenzoate
3609-53-8

methyl 4-acetylbenzoate

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

Conditions
ConditionsYield
With Nonafluorobutanesulfonyl fluoride; tert-butylimino-tri(pyrrolidino)phosphorane In N,N-dimethyl-formamide at -10 - 20℃;97%
methyl 4-iodobenzoate
619-44-3

methyl 4-iodobenzoate

trimethylsilylacetylene
1066-54-2

trimethylsilylacetylene

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

Conditions
ConditionsYield
Stage #1: methyl 4-iodobenzoate; trimethylsilylacetylene With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride for 24h;
Stage #2: With potassium carbonate In methanol for 48h;
91%
Stage #1: methyl 4-iodobenzoate; trimethylsilylacetylene With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine at 90℃; for 24h; Inert atmosphere;
Stage #2: With potassium carbonate In methanol at 20℃; for 3h; Inert atmosphere;
70%
Stage #1: methyl 4-iodobenzoate; trimethylsilylacetylene With copper(l) iodide; bis(triphenylphosphine)palladium(II)-chloride; triethylamine In tetrahydrofuran at 70℃; Inert atmosphere;
Stage #2: With tetrabutyl ammonium fluoride In tetrahydrofuran at 20℃; for 1h;
4-(methoxycarbonyl)phenylethynyldiphenylphosphine oxide

4-(methoxycarbonyl)phenylethynyldiphenylphosphine oxide

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

Conditions
ConditionsYield
With methylmagnesium bromide In tetrahydrofuran; diethyl ether at -78 - 0℃; for 0.25h; Inert atmosphere;91%
methyl 4-iodobenzoate
619-44-3

methyl 4-iodobenzoate

ethynylzinc bromide

ethynylzinc bromide

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 22℃; for 1h;86%
dimethyl 1-(1-diazo-2-oxopropyl)phosphonate
90965-06-3

dimethyl 1-(1-diazo-2-oxopropyl)phosphonate

methyl 4-formylbenzoate
1571-08-0

methyl 4-formylbenzoate

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

Conditions
ConditionsYield
With potassium tert-butylate In methanol at 100℃; for 0.5h;84%
With potassium carbonate In tetrahydrofuran; methanol at 20℃; for 12h;
With potassium carbonate In tetrahydrofuran; methanol at 20℃;23 mg
4-methoxycarbonylphenyl bromide
619-42-1

4-methoxycarbonylphenyl bromide

trimethylsilylacetylene
1066-54-2

trimethylsilylacetylene

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

Conditions
ConditionsYield
With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); diisopropylamine at 20℃; for 24.5h; Inert atmosphere; Reflux;83.1%
Stage #1: 4-methoxycarbonylphenyl bromide; trimethylsilylacetylene With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran at 60℃; for 24h; Inert atmosphere;
Stage #2: With methanol; potassium hydroxide In tetrahydrofuran at 20℃; for 0.5h;
30%
2-methylphenyl aldehyde
529-20-4

2-methylphenyl aldehyde

(4-methoxycarbonylphenyl)ethynyl iodide

(4-methoxycarbonylphenyl)ethynyl iodide

allyl-trimethyl-silane
762-72-1

allyl-trimethyl-silane

A

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

B

methyl 4-(3-(o-tolyl)hex-5-en-1-yn-1-yl)benzoate

methyl 4-(3-(o-tolyl)hex-5-en-1-yn-1-yl)benzoate

Conditions
ConditionsYield
Stage #1: 2-methylphenyl aldehyde; (4-methoxycarbonylphenyl)ethynyl iodide With bis(cyclopentadienyl)titanium dichloride; P(p-CH3OC6H4)3; zinc In dichloromethane at 20℃; Inert atmosphere;
Stage #2: allyl-trimethyl-silane With acetic anhydride In dichloromethane at 0℃; Inert atmosphere;
A n/a
B 81%
4-(methoxycarbonyl)benzyl alcohol
6908-41-4

4-(methoxycarbonyl)benzyl alcohol

dimethyl 1-(1-diazo-2-oxopropyl)phosphonate
90965-06-3

dimethyl 1-(1-diazo-2-oxopropyl)phosphonate

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

Conditions
ConditionsYield
With manganese(IV) oxide; potassium carbonate In tetrahydrofuran; methanol at 20℃;78%
With manganese(IV) oxide; potassium carbonate In tetrahydrofuran; methanol at 20℃; for 18h;78%
1,1-dibromo-2-(4-methoxycarbonylphenyl)ethene
253684-21-8

1,1-dibromo-2-(4-methoxycarbonylphenyl)ethene

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

Conditions
ConditionsYield
With caesium carbonate; dimethyl sulfoxide at 115℃; for 12h;78%
With caesium carbonate In dimethyl sulfoxide at 115℃; Sealed tube; Inert atmosphere;33%
(2RS,3SR)-2,3-dibromo-3-(4-methoxycarbonylphenyl)propanoic acid

(2RS,3SR)-2,3-dibromo-3-(4-methoxycarbonylphenyl)propanoic acid

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 115℃; for 12h;75%
Multi-step reaction with 2 steps
1: 99 percent / triethylamine / dimethylformamide / 0.02 h / microwave irradiation
2: 99 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethylformamide / 1 h / microwave irradiation
View Scheme
Multi-step reaction with 2 steps
1: triethylamine / dimethylformamide / 1 h / microwave irradiation
2: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethylformamide / 0.02 h / microwave irradiation
View Scheme
methyl 4-(3-hydroxypropynyl)benzoate
61266-36-2

methyl 4-(3-hydroxypropynyl)benzoate

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

Conditions
ConditionsYield
With manganese(IV) oxide; potassium hydroxide In benzene for 0.25h; Ambient temperature;72%
With manganese(IV) oxide; potassium hydroxide In benzene at 20℃; for 0.25h;72%
methanol
67-56-1

methanol

4-Ethynyl-benzoic acid
10602-00-3

4-Ethynyl-benzoic acid

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃;72%
p-(iodophenyl)carboxaldehyde
15164-44-0

p-(iodophenyl)carboxaldehyde

trimethylsilylacetylene
1066-54-2

trimethylsilylacetylene

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

Conditions
ConditionsYield
Stage #1: p-(iodophenyl)carboxaldehyde; trimethylsilylacetylene With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine at 90℃; for 24h; Sonogashira Cross-Coupling; Inert atmosphere;
Stage #2: With potassium carbonate In methanol at 20℃; for 3h; Inert atmosphere;
70%
methyl 4-iodobenzoate
619-44-3

methyl 4-iodobenzoate

Propiolic acid
471-25-0

Propiolic acid

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,4-di(diphenylphosphino)-butane In dimethyl sulfoxide at 0 - 60℃; for 5h; Sealed flask;42%
methanol
67-56-1

methanol

1-carboxamido-4-ethynylbenzene
90347-86-7

1-carboxamido-4-ethynylbenzene

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

Conditions
ConditionsYield
With sulfuric acid
2-ethynyl-1,3-butadiene
6929-96-0

2-ethynyl-1,3-butadiene

propynoic acid methyl ester
922-67-8

propynoic acid methyl ester

A

methyl 3-ethynylbenzoate
10602-06-9

methyl 3-ethynylbenzoate

B

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

C

4-Ethynyl-cyclohexa-1,4-dienecarboxylic acid methyl ester

4-Ethynyl-cyclohexa-1,4-dienecarboxylic acid methyl ester

D

5-Ethynyl-cyclohexa-1,4-dienecarboxylic acid methyl ester

5-Ethynyl-cyclohexa-1,4-dienecarboxylic acid methyl ester

Conditions
ConditionsYield
In toluene at 75℃; for 6h; Title compound not separated from byproducts;
4-(methoxycarbonyl)benzyl alcohol
6908-41-4

4-(methoxycarbonyl)benzyl alcohol

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: MnO2 / tetrahydrofuran / 4 h / 20 °C
2: 23 mg / K2CO3 / tetrahydrofuran; methanol / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: MnO2 / tetrahydrofuran / 20 °C
2: K2CO3 / methanol; tetrahydrofuran / 12 h / 20 °C
View Scheme
methyl 4-iodobenzoate
619-44-3

methyl 4-iodobenzoate

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 97 percent / Pd(PPh3)2Cl2; CuI; triethylamine / 2 h / 20 °C
2: 81 percent / sodium carbonate / methanol / 3 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: 100 percent / (Ph3)2PdCl2; Ph3P; CuI / Et3N / 68 h / Heating
2: 98 percent / NaH / toluene / 110 °C
View Scheme
Multi-step reaction with 2 steps
1: 95 percent / Pd(PPh3)2Cl2; CuI; triethylamine / tetrahydrofuran / 1.5 h / 80 °C
2: 99 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.5 h / -20 °C
View Scheme
(E)-4-(methoxycarbonyl)cinnamic acid
117390-07-5

(E)-4-(methoxycarbonyl)cinnamic acid

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Br2 / CHCl3
2: 99 percent / triethylamine / dimethylformamide / 0.02 h / microwave irradiation
3: 99 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethylformamide / 1 h / microwave irradiation
View Scheme
Multi-step reaction with 2 steps
1: chloroform / 20 - 60 °C / Irradiation; Bromination
2: potassium carbonate / dimethyl sulfoxide / 12 h / 115 °C
View Scheme
4-methoxycarbonylphenyl bromide
619-42-1

4-methoxycarbonylphenyl bromide

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 92 percent / CuI; PPh3; Pd(PPh3)2Cl2 / triethylamine; tetrahydrofuran / Heating
2: 99 percent / K2CO3 / methanol; CH2Cl2
View Scheme
Multi-step reaction with 2 steps
1: 94 percent Chromat. / PdCl2(1,1'-bis(diphenylphosphino)ferrocene), CuI, Et3N / benzene / 2 h / 70 °C
2: 72 percent / MnO2, KOH powder / benzene / 0.25 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: triethylamine / Pd(OAc)2, PPh3 / tetrahydrofuran / 4 h / Heating
2: Bu4NF / tetrahydrofuran / 0.33 h
View Scheme
4-iodobenzoic acid
619-58-9

4-iodobenzoic acid

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 88 percent / K2CO3 / dimethylsulfoxide
2: 95 percent / Pd(PPh3)2Cl2; CuI; triethylamine / tetrahydrofuran / 1.5 h / 80 °C
3: 99 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.5 h / -20 °C
View Scheme
Multi-step reaction with 3 steps
1: sulfuric acid / Reflux
2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 20 °C / Inert atmosphere; Sealed tube; Schlenk technique
3: potassium carbonate / dichloromethane; methanol / 6 h / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: acetyl chloride / 12 h / 60 °C
2: bis-triphenylphosphine-palladium(II) chloride; triethylamine; copper(l) iodide / 12 h / 75 °C
3: methanol; potassium carbonate / 6 h / 25 °C
View Scheme
methyl 4-iodobenzoate
619-44-3

methyl 4-iodobenzoate

Co2(CO)8

Co2(CO)8

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 98 percent / copper(I) iodide; diisopropylethylamine / bis(triphenylphosphine)palladium(II) dichloride / tetrahydrofuran / 18 h / 60 °C
2: 0.49 g / potassium carbonate / methanol; CH2Cl2 / 2 h / 20 °C
View Scheme
4-cyanophenyl methyl ketone
1443-80-7

4-cyanophenyl methyl ketone

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: aq. H2SO4 / 150 °C
2: (i) PCl5, POCl3, (ii) NaNH2, liq. NH3, Et2O
3: H2SO4
View Scheme
4-acetyl-benzoic acid
586-89-0

4-acetyl-benzoic acid

1.4-diacetyl-benzene; terephthalic acid

1.4-diacetyl-benzene; terephthalic acid

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (i) PCl5, POCl3, (ii) NaNH2, liq. NH3, Et2O
2: H2SO4
View Scheme
4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

1-iodo-2-nitro-4-phenylethynyl-benzene
518980-39-7

1-iodo-2-nitro-4-phenylethynyl-benzene

4-(2-nitro-4-phenylethynylphenylethynyl)benzoic acid methyl ester
546112-69-0

4-(2-nitro-4-phenylethynylphenylethynyl)benzoic acid methyl ester

Conditions
ConditionsYield
With copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) In tetrahydrofuran at 20℃; for 1h; Sonogashira-Castro-Stephens coupling;100%
4-iodobenzonitrile
3058-39-7

4-iodobenzonitrile

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

methyl 4-((4-cyanophenyl)ethynyl)benzoate

methyl 4-((4-cyanophenyl)ethynyl)benzoate

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine In tetrahydrofuran for 5h; Inert atmosphere;100%
para-diiodobenzene
624-38-4

para-diiodobenzene

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

dimethyl 4,4′-[1,4-phenylenebis(ethyne-2,1-diyl)]dibenzoate
848850-13-5

dimethyl 4,4′-[1,4-phenylenebis(ethyne-2,1-diyl)]dibenzoate

Conditions
ConditionsYield
Stage #1: 4-ethynylbenzoic acid methyl ester With triethylamine for 0.166667h;
Stage #2: para-diiodobenzene With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide at 50℃; Inert atmosphere;
99%
With copper(l) iodide; bis(triphenylphosphine)palladium(II) chloride In triethylamine at 50℃; Inert atmosphere;99%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 20℃; Sonogashira cross-coupling reaction;46%
4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

(4-methoxycarbonylphenyl)ethynyl iodide

(4-methoxycarbonylphenyl)ethynyl iodide

Conditions
ConditionsYield
With aluminum oxide; N-iodo-succinimide In acetonitrile at 80℃; for 1h; Molecular sieve;99%
With N-chlorobenzenesulfonamide; potassium iodide In acetonitrile at 20℃; for 2h;97%
With N-iodo-succinimide; acetic acid In acetonitrile at 80℃; for 1.5h; Molecular sieve;97%
t-butoxycarbonylhydrazine
870-46-2

t-butoxycarbonylhydrazine

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

(E)-tert-butyl 2-(1-(4-(methoxycarbonyl)phenyl)ethylidene)hydrazinecarboxylate

(E)-tert-butyl 2-(1-(4-(methoxycarbonyl)phenyl)ethylidene)hydrazinecarboxylate

Conditions
ConditionsYield
With [(THD-Dipp)AuOTf] In neat (no solvent) at 100℃; Green chemistry; regioselective reaction;99%
1H-imidazole
288-32-4

1H-imidazole

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

(E)-methyl 4-(2-(1H-imidazole-1-yl)vinyl)benzoate

(E)-methyl 4-(2-(1H-imidazole-1-yl)vinyl)benzoate

Conditions
ConditionsYield
With hexa[tri(dimethylamino)phosphazene]cyclotriphosphazene In dimethyl sulfoxide at 120℃; for 24h; Inert atmosphere; Glovebox; stereoselective reaction;99%
4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

4-Ethynyl-benzoic acid
10602-00-3

4-Ethynyl-benzoic acid

Conditions
ConditionsYield
With water; sodium hydroxide In tetrahydrofuran at 20℃; for 2h; Inert atmosphere;98.64%
With lithium hydroxide In methanol; water for 2h;77%
With lithium hydroxide In methanol; water for 2h;77%
4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

methyl 4-acetylbenzoate
3609-53-8

methyl 4-acetylbenzoate

Conditions
ConditionsYield
With 5,10,15-tris(pentafluorophenyl)corrole cobalt(III) triphenyl phosphine; sulfuric acid; water In methanol at 80℃; for 36h;98%
With trifluorormethanesulfonic acid; water In 2,2,2-trifluoroethanol at 25 - 70℃; for 45h; Sealed tube; regioselective reaction;94%
With indium(III) triflate; water; toluene-4-sulfonic acid In 1,2-dichloro-ethane for 19h; Sealed tube; Reflux; regioselective reaction;77%
With methanol; platinum(IV) oxide; water; toluene-4-sulfonic acid at 90℃; for 5h; Sealed tube;68%
With 2CHF3O3S*C29H35NO6P2Pt; water; sodium dodecyl-sulfate at 80℃; Micellar solution;26 %Chromat.
2-iodo-4-methoxybromobenzene
4897-68-1

2-iodo-4-methoxybromobenzene

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

methyl 4-[(2-bromo-5-methoxyphenyl)ethynyl]benzoate
1378284-25-3

methyl 4-[(2-bromo-5-methoxyphenyl)ethynyl]benzoate

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran at 20℃; for 4h; Inert atmosphere;98%
4'-azido-2,2'-bipyridine-N'-oxide
1309763-77-6

4'-azido-2,2'-bipyridine-N'-oxide

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

4'-(4-(4-(methoxycarbonyl)phenyl)-1H-1,2,3-triazol-1-yl)-2,2'-bipyridine N'-oxide
1309763-84-5

4'-(4-(4-(methoxycarbonyl)phenyl)-1H-1,2,3-triazol-1-yl)-2,2'-bipyridine N'-oxide

Conditions
ConditionsYield
With copper(ll) sulfate pentahydrate; sodium L-ascorbate In dichloromethane; water at 20℃; for 20h; Inert atmosphere;98%
4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

1,3,5-tris(azidomethyl)benzene
107864-71-1

1,3,5-tris(azidomethyl)benzene

C39H33N9O6

C39H33N9O6

Conditions
ConditionsYield
With triethylamine In water; tert-butyl alcohol at 50℃; for 7h; Schlenk technique;98%
4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

7-(diethylamino)-2-oxo-2H-chromen-4-yl trifluoromethanesulfonate

7-(diethylamino)-2-oxo-2H-chromen-4-yl trifluoromethanesulfonate

methyl 4-((7-(diethylamino)-2-oxo-2H-chromen-4-yl)ethynyl)benzoate

methyl 4-((7-(diethylamino)-2-oxo-2H-chromen-4-yl)ethynyl)benzoate

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran at 20℃; for 1h; Sonogashira Cross-Coupling; Inert atmosphere; Microwave irradiation;98%
4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

2-fluoro-5-iodopyridine
171197-80-1

2-fluoro-5-iodopyridine

methyl 4-((6-fluoropyridin-3-yl)ethynyl)benzoate

methyl 4-((6-fluoropyridin-3-yl)ethynyl)benzoate

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran at 20℃; for 16h;98%
2-acetylpropanoic acid ethyl ester
609-14-3

2-acetylpropanoic acid ethyl ester

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

ethyl 2-acetyl-2-methyl-3-(4-methoxycarbonylphenyl)-3-butenoate

ethyl 2-acetyl-2-methyl-3-(4-methoxycarbonylphenyl)-3-butenoate

Conditions
ConditionsYield
In(OSO2CF3)3 at 140℃; for 18h;97%
indium(III) triflate at 140℃; for 18h;97%
With indium(III) triflate97%
4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

benzyl azide
622-79-7

benzyl azide

1-benzyl-1H-[1,2,3]triazole-4-carboxylic acid methyl ester
76003-76-4

1-benzyl-1H-[1,2,3]triazole-4-carboxylic acid methyl ester

Conditions
ConditionsYield
With copper(l) iodide; 1-decylimidazole at 25℃; for 2h; neat (no solvent);97%
5-iodo-1,1,3,3-tetramethyl-1,3-disilaindane
1394173-31-9

5-iodo-1,1,3,3-tetramethyl-1,3-disilaindane

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

methyl 4-(1,1,3,3-tetramethyl-1,3-disilaindan-5-ylethynyl)benzoate
1394173-35-3

methyl 4-(1,1,3,3-tetramethyl-1,3-disilaindan-5-ylethynyl)benzoate

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 20℃; for 17h; Sonogashira Cross-Coupling; Inert atmosphere;97%
4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

1,2-diamino-benzene
95-54-5

1,2-diamino-benzene

C16H12N2O3

C16H12N2O3

Conditions
ConditionsYield
With oxygen; potassium carbonate; copper(l) chloride In methanol; acetonitrile at 25℃; for 2.5h; Irradiation; Green chemistry;97%
[RuCl(dppe)2]OTf
253687-41-1

[RuCl(dppe)2]OTf

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

trans-[Ru(dppe)2(C≡CC6H4CO2Me)Cl]

trans-[Ru(dppe)2(C≡CC6H4CO2Me)Cl]

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane at 20℃; for 1h; Inert atmosphere; Schlenk technique;97%
4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

C20H16O4

C20H16O4

Conditions
ConditionsYield
With C17H37FeN3P2 In tetrahydrofuran at 20℃; Inert atmosphere; Glovebox; stereoselective reaction;97%
With [CoBr2(TriPhos)]; zinc(II) iodide; zinc In acetonitrile at 0 - 20℃; for 4h; Inert atmosphere; Schlenk technique; diastereoselective reaction;67%
4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

Methyl 4-(1,2,2-triiodovinyl)benzoate

Methyl 4-(1,2,2-triiodovinyl)benzoate

Conditions
ConditionsYield
Stage #1: 4-ethynylbenzoic acid methyl ester With [bis(acetoxy)iodo]benzene; tetra-(n-butyl)ammonium iodide In acetonitrile at 20℃; for 3h;
Stage #2: With [bis(acetoxy)iodo]benzene; potassium iodide In water; acetonitrile at 20℃; for 15h;
97%
Stage #1: 4-ethynylbenzoic acid methyl ester With [bis(acetoxy)iodo]benzene; tetra-(n-butyl)ammonium iodide In acetonitrile at 20℃; for 3h;
Stage #2: With [bis(acetoxy)iodo]benzene; potassium iodide In water; acetonitrile at 20℃; for 15.3333h; chemoselective reaction;
91%
4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

C10H7(2)HO2

C10H7(2)HO2

Conditions
ConditionsYield
With water-d2; silver trifluoroacetate In dichloromethane at 25℃; for 16h;97%
4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

2-bromo-5-(4-n-hexylphenylethynyl)-4-nitro-N-acetylaniline
421554-58-7

2-bromo-5-(4-n-hexylphenylethynyl)-4-nitro-N-acetylaniline

methyl 4-[2-acetamido-4-(4-n-hexylphenylethynyl)-5-nitro]phenylethynylbenzoate

methyl 4-[2-acetamido-4-(4-n-hexylphenylethynyl)-5-nitro]phenylethynylbenzoate

Conditions
ConditionsYield
With copper(l) iodide; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride In tetrahydrofuran at 75℃; for 72h; Castro-Stephens/Sonogashira coupling;96%
4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

dimethyl 4,4′-(buta-1,3-diyne-1,4-diyl)dibenzoate

dimethyl 4,4′-(buta-1,3-diyne-1,4-diyl)dibenzoate

Conditions
ConditionsYield
With copper oxide supported on mesoporous manganese oxide; air In toluene at 105℃; for 4h;96%
With piperidine In toluene at 60℃; under 760.051 Torr; for 24h;95%
With copper diacetate In pyridine at 20℃; for 46h; Eglinton Coupling; Schlenk technique; Inert atmosphere;89%
1,4-diiodo-2,3,5,6-tetrafluorobenzene
392-57-4

1,4-diiodo-2,3,5,6-tetrafluorobenzene

4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

1,4-bis(4-carbomethoxyphenylethynyl)-2,3,5,6-tetrafluorobenzene

1,4-bis(4-carbomethoxyphenylethynyl)-2,3,5,6-tetrafluorobenzene

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine for 3h; Sonogashira cross-coupling reaction; Heating;96%
With copper(l) iodide; bis(triphenylphosphine)palladium(II) chloride In triethylamine at 50℃; Inert atmosphere;91%
4-ethynylbenzoic acid methyl ester
3034-86-4

4-ethynylbenzoic acid methyl ester

3-butylamino-N,N-dimethyl-(Z)-2-butenamide
827574-12-9

3-butylamino-N,N-dimethyl-(Z)-2-butenamide

2-acetyl-3-(4-methoxyvarbonylphenyl)-N,N-dimethyl-2-butenamide

2-acetyl-3-(4-methoxyvarbonylphenyl)-N,N-dimethyl-2-butenamide

Conditions
ConditionsYield
Stage #1: 4-ethynylbenzoic acid methyl ester; 3-butylamino-N,N-dimethyl-(Z)-2-butenamide With diethylzinc In hexane at 70℃; for 15h;
Stage #2: With hydrogenchloride In tetrahydrofuran; hexane at 20℃;
96%

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