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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

2-Chloro-5-fluoropyridine Manufacturer/High quality/Best price/In stock

Cas:31301-51-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 2-Chloro-5-Fluoropyridine supplier in China

Cas:31301-51-6

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com Product Name 2-Chloro-5-fluoropyridine CAS No. 31301-51-6 Appearance

5-Fluoro-2-chloropyridine

Cas:31301-51-6

Min.Order:1 Gram

FOB Price: $8.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

Factory supply 2-Chloro-5-fluoropyridine CAS 31301-51-6 with fast delivery Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food

Factory supply 2-Chloro-5-fluoropyridine CAS 31301-51-6 with fast delivery

Cas:31301-51-6

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car

2-chloro-5-fluoropyridine

Cas:31301-51-6

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

The company has advanced technology, as well as a large number of excellent R & D team, to provide customers from the grams to one hundred kilograms and tons of high-quality products, competitive prices and quality service Appearance:White or o

2-Chloro-5-fluoropyridine

Cas:31301-51-6

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2-chloro-5-fluoropyridine

Cas:31301-51-6

Min.Order:1

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Large Stock 99.0% 2-Chloro-5-fluoropyridine 31301-51-6 Producer

Cas:31301-51-6

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-Chloro-5-fluoropyridine

Cas:31301-51-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

discount 2-Chloro-5-fluoropyridine

Cas:31301-51-6

Min.Order:1 Gram

FOB Price: $1.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

2-Chloro-5-fluoropyridine

Cas:31301-51-6

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 31301-51-6 with fast shipping

Cas:31301-51-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: 2-Chloro-5-fluoropyridine Synonyms: 2-chloro-5-fluoro pyridine CAS: 31301-51-6 MF: C8H6F3NO2 Appearance:White powder Storage:Store in cool and dry place, away from sun light. Package:25kg/drum Application:Agrochemical Intermediates, Dyes

2-Chloro-5-fluoropyridine

Cas:31301-51-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2-Chloro-5-fluoropyridine 31301-51-6

Cas:31301-51-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Qingdao Beluga Import and Export Co., LTD

2-Chloro-5-fluoropyridine CAS:31301-51-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organi

2-Chloro-5-fluoropyridine CAS:31301-51-6

Cas:31301-51-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2-Chloro-5-fluoropyridine

Cas:31301-51-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:31301-51-6

Cas:31301-51-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2-Chloro-5-Fluoropyridine

Cas:31301-51-6

Min.Order:0

Negotiable

Type:Manufacturers

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Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By Se

2-Chloro-5-fluoropyridine

Cas:31301-51-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2-Chloro-5-fluoropyridine

Cas:31301-51-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-chloro-5-fluoropyridine

Cas:31301-51-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

2-Chloro-5-fluoropyridine

Cas:31301-51-6

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

2-Chloro-5-fluoropyridine

Cas:31301-51-6

Min.Order:1 Gram

Negotiable

Type:Other

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 2-Chloro-5-fluoropyridine

Cas:31301-51-6

Min.Order:100 Gram

Negotiable

Type:Other

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

5-Fluoro-2-chloropyridine CAS NO.31301-51-6

Cas:31301-51-6

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:colorless or light yellow liquid Storage:In Room Temperature Package:25kg/drum, or as per your request. Application:For medicine , pesticide intermediates Transportation: as per

2-Chloro-5-fluoropyridine

Cas:31301-51-6

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Shanghai Minstar Chemical Co., Ltd

2-Chloro-5-fluoropyridine Chemical Properties Melting point 19℃ Boiling point 74 °C / 38mmHg density 1.297 g/mL at 25 °C refractive index n20/D 1.503 Fp 108 °C pka -2.20±0.10(Predicted) InChIKey QOGXQLSFJC

2-Chloro-5-fluoropyridine

Cas:31301-51-6

Min.Order:200 Kilogram

FOB Price: $65.0

Type:Lab/Research institutions

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

2-Chloro-5-fluoropyridine

Cas:31301-51-6

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

2-Chloro-5-fluoropyridine

Cas:31301-51-6

Min.Order:0

Negotiable

Type:Trading Company

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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

2-Chloro-5-fluoropyridine

Cas:31301-51-6

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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Synthetic route

5-bromo-2-chloropyridine
53939-30-3

5-bromo-2-chloropyridine

2-chloro-5-fluoropyridine
31301-51-6

2-chloro-5-fluoropyridine

Conditions
ConditionsYield
Stage #1: 5-bromo-2-chloropyridine With TurboGrignard In tetrahydrofuran; 1,4-dioxane at 0℃; Inert atmosphere;
Stage #2: With N-fluorobis(benzenesulfon)imide In dichloromethane; octadecafluorodecahydronaphthalene (cis+trans) at -78 - 20℃; Inert atmosphere;
75%
Stage #1: 5-bromo-2-chloropyridine With TurboGrignard In tetrahydrofuran at 0℃; Inert atmosphere;
Stage #2: With N-fluorobis(benzenesulfon)imide In dichloromethane; octadecafluorodecahydronaphthalene (cis+trans) at -78 - 25℃; Inert atmosphere;
75%
2-chloropyridine-5-yldiazonium tetrafluoroborate

2-chloropyridine-5-yldiazonium tetrafluoroborate

2-chloro-5-fluoropyridine
31301-51-6

2-chloro-5-fluoropyridine

Conditions
ConditionsYield
In n-heptane for 3h; Heating;70%
In n-heptane at 105℃; for 2h;
In n-heptane at 105℃; for 2h;
6-Chloro-pyridin-3-ylamine
5350-93-6

6-Chloro-pyridin-3-ylamine

2-chloro-5-fluoropyridine
31301-51-6

2-chloro-5-fluoropyridine

Conditions
ConditionsYield
With tert.-butylnitrite; boron trifluoride diethyl etherate In 1,2-dichloro-benzene at 105℃; for 0.75h; Balz-Schiemann Reaction;36 %Spectr.
2-choro-5-iodopyridine
69045-79-0

2-choro-5-iodopyridine

2-chloro-5-fluoropyridine
31301-51-6

2-chloro-5-fluoropyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 20 °C
1.2: 0.5 h
2.1: copper(II) methanesulfonate; potassium fluoride; 18-crown-6 ether / N,N-dimethyl-formamide / 18 h / 60 °C
View Scheme
C14H14ClIN(1+)*BF4(1-)

C14H14ClIN(1+)*BF4(1-)

2-chloro-5-fluoropyridine
31301-51-6

2-chloro-5-fluoropyridine

Conditions
ConditionsYield
With potassium fluoride; 18-crown-6 ether; copper(II) methanesulfonate In N,N-dimethyl-formamide at 60℃; for 18h; Reagent/catalyst; Time; Solvent;33 %Spectr.
5-[1-(methylsulfonimidoyl)ethyl]-2-(trifluoromethyl)pyridine
946578-43-4

5-[1-(methylsulfonimidoyl)ethyl]-2-(trifluoromethyl)pyridine

2-chloro-5-fluoropyridine
31301-51-6

2-chloro-5-fluoropyridine

3-[1-ethyl(N-(2-(5-chloro)pyridine)-sulfoximinyl)(methyl)]-6-trifluoromethylpyridine
1106808-39-2

3-[1-ethyl(N-(2-(5-chloro)pyridine)-sulfoximinyl)(methyl)]-6-trifluoromethylpyridine

Conditions
ConditionsYield
With caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 150℃; for 0.5h; Microwave irradiation;99%
2-chloro-5-fluoropyridine
31301-51-6

2-chloro-5-fluoropyridine

trimethoxonium tetrafluoroborate
420-37-1

trimethoxonium tetrafluoroborate

C6H6ClFN(1+)*BF4(1-)
1622456-58-9

C6H6ClFN(1+)*BF4(1-)

Conditions
ConditionsYield
In dichloromethane at 20℃;99%
piperidine
110-89-4

piperidine

2-chloro-5-fluoropyridine
31301-51-6

2-chloro-5-fluoropyridine

5-fluoro-2-(piperidin-1-yl)pyridine

5-fluoro-2-(piperidin-1-yl)pyridine

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; XPhos In toluene at 100℃; for 24h; Catalytic behavior; Reagent/catalyst; Inert atmosphere;99%
2-chloro-5-fluoropyridine
31301-51-6

2-chloro-5-fluoropyridine

1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylic acid tert-butyl ester
930785-40-3

1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylic acid tert-butyl ester

tert-butyl 4-(5-fluoropyridin-2-yl)-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate

tert-butyl 4-(5-fluoropyridin-2-yl)-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate

Conditions
ConditionsYield
With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl) palladium(II) dichloride; caesium carbonate In toluene at 120℃; for 72h;98%
2-chloro-5-fluoropyridine
31301-51-6

2-chloro-5-fluoropyridine

phenylboronic acid
98-80-6

phenylboronic acid

2-phenyl-5-fluoropyridine
512171-81-2

2-phenyl-5-fluoropyridine

Conditions
ConditionsYield
With C43H46ClF6N3Pd; potassium hydroxide In water; isopropyl alcohol at 80℃; for 2h; Suzuki-Miyaura Coupling; Inert atmosphere;95%
With palladium diacetate; caesium carbonate; tricyclohexylphosphine tetrafluoroborate In 1,4-dioxane at 120℃; for 16h;
2-chloro-5-fluoropyridine
31301-51-6

2-chloro-5-fluoropyridine

5,5’-difluoro-2,2’-bipyridine
1041837-79-9

5,5’-difluoro-2,2’-bipyridine

Conditions
ConditionsYield
With potassium hydroxide In water; N,N-dimethyl-formamide at 45℃; for 24h; Ullmann Condensation; Inert atmosphere;94%
1,2,4-Triazole
288-88-0

1,2,4-Triazole

2-chloro-5-fluoropyridine
31301-51-6

2-chloro-5-fluoropyridine

C7H5FN4

C7H5FN4

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 100℃; Inert atmosphere;93%
2-chloro-5-fluoropyridine
31301-51-6

2-chloro-5-fluoropyridine

2-chloro-5-fluoropyridine 1-oxide
405230-79-7

2-chloro-5-fluoropyridine 1-oxide

Conditions
ConditionsYield
With dihydrogen peroxide; trifluoroacetic acid at 70℃; for 16h; Inert atmosphere;90%
Stage #1: 2-chloro-5-fluoropyridine With dihydrogen peroxide; trifluoroacetic acid In water at 70 - 75℃;
Stage #2: With ammonium hydroxide In dichloromethane; water
74%
With dihydrogen peroxide; trifluoroacetic acid at 70℃;71.2%
2-chloro-5-fluoropyridine
31301-51-6

2-chloro-5-fluoropyridine

2-methyl-1-tetralone
1590-08-5

2-methyl-1-tetralone

2-(5-fluoropyridin-2-yl)-2-methyl-3,4-dihydronaphthalen-1(2H)-one

2-(5-fluoropyridin-2-yl)-2-methyl-3,4-dihydronaphthalen-1(2H)-one

Conditions
ConditionsYield
With (R)-(-)-5,5’-bis(diphenyl;phosphine)-2,2,2’,2’-tetrafluoro-4,4’-bi-1,3-benzodioxole; bis(1,5-cyclooctadiene)nickel (0); sodium t-butanolate In toluene at 70℃; for 28h; Inert atmosphere; optical yield given as %ee; enantioselective reaction;89%
2-chloro-5-fluoropyridine
31301-51-6

2-chloro-5-fluoropyridine

4-phenoxyphenylboronic acid
51067-38-0

4-phenoxyphenylboronic acid

C17H12FNO

C17H12FNO

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In water; toluene at 110℃; for 48h; Suzuki Coupling; Inert atmosphere;88.4%
2-chloro-5-fluoropyridine
31301-51-6

2-chloro-5-fluoropyridine

2,3-dihydro-2-methyl-1H-inden-1-one
17496-14-9

2,3-dihydro-2-methyl-1H-inden-1-one

2-methyl-2-(5-flouropyridin-2-yl)-2,3-dihydro-1H-inden-1-one

2-methyl-2-(5-flouropyridin-2-yl)-2,3-dihydro-1H-inden-1-one

Conditions
ConditionsYield
With (R)-(-)-5,5’-bis(diphenyl;phosphine)-2,2,2’,2’-tetrafluoro-4,4’-bi-1,3-benzodioxole; bis(1,5-cyclooctadiene)nickel (0); sodium t-butanolate In toluene at 70℃; for 28h; Inert atmosphere; optical yield given as %ee; enantioselective reaction;86%
1H-imidazole
288-32-4

1H-imidazole

2-chloro-5-fluoropyridine
31301-51-6

2-chloro-5-fluoropyridine

2-(1H-imidazolyl)pyridine
25700-14-5

2-(1H-imidazolyl)pyridine

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20 - 100℃; Inert atmosphere;86%
2-chloro-5-fluoropyridine
31301-51-6

2-chloro-5-fluoropyridine

C15H24N2O

C15H24N2O

C20H26ClN3O

C20H26ClN3O

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; lithium hexamethyldisilazane at 90℃; for 16h; Inert atmosphere;85.74%
2-chloro-5-fluoropyridine
31301-51-6

2-chloro-5-fluoropyridine

6,7,8,9-tetrahydro-8-methylpyrido[1,2-a]indol-9-one

6,7,8,9-tetrahydro-8-methylpyrido[1,2-a]indol-9-one

C18H15FN2O

C18H15FN2O

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)nickel (0); (R)-DIFLUOROPHOS; sodium t-butanolate In toluene at 85℃; for 48h; enantioselective reaction;82%
2-chloro-5-fluoropyridine
31301-51-6

2-chloro-5-fluoropyridine

(4-isopropylbenzaldehyde)
122-03-2

(4-isopropylbenzaldehyde)

(6-chloro-3-fluoropyridin-2-yl)(4-isopropylphenyl)methanol

(6-chloro-3-fluoropyridin-2-yl)(4-isopropylphenyl)methanol

Conditions
ConditionsYield
Stage #1: 2-chloro-5-fluoropyridine With sodium; diisopropylamine; isoprene In tetrahydrofuran at -78℃; for 0.000138889h; Flow reactor;
Stage #2: (4-isopropylbenzaldehyde) In tetrahydrofuran Flow reactor;
77%
2-chloro-5-fluoropyridine
31301-51-6

2-chloro-5-fluoropyridine

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

5-fluoro-2-phenethylpyridine

5-fluoro-2-phenethylpyridine

Conditions
ConditionsYield
Stage #1: 1-phenyl-2-bromoethane With iodine; magnesium In tetrahydrofuran at 0 - 80℃; for 0.5h; Inert atmosphere;
Stage #2: 2-chloro-5-fluoropyridine With iron(III)-acetylacetonate In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 0 - 20℃; for 0.5h; Inert atmosphere;
77%
2-chloro-5-fluoropyridine
31301-51-6

2-chloro-5-fluoropyridine

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

2-chloro-5-fluoroisonicotinaldehyde
884494-54-6

2-chloro-5-fluoroisonicotinaldehyde

Conditions
ConditionsYield
Stage #1: 2-chloro-5-fluoropyridine With lithium diisopropyl amide In tetrahydrofuran at -60℃; for 2h; Inert atmosphere;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at -60℃; for 2h;
74%
Stage #1: 2-chloro-5-fluoropyridine With n-butyllithium In tetrahydrofuran; hexane at -70℃; for 0.5h; Inert atmosphere;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; hexane at -70℃; for 1h;
3,6-diazabicyclo[3.1.1]heptane-6-carboxylic acid tert-butyl ester
869494-16-6

3,6-diazabicyclo[3.1.1]heptane-6-carboxylic acid tert-butyl ester

2-chloro-5-fluoropyridine
31301-51-6

2-chloro-5-fluoropyridine

tert-butyl 3-(5-chloropyrazine-2-yl)-3,6-diazabicyclo[3.1.1]heptane-6-carboxylate

tert-butyl 3-(5-chloropyrazine-2-yl)-3,6-diazabicyclo[3.1.1]heptane-6-carboxylate

Conditions
ConditionsYield
In dimethyl sulfoxide at 120℃;74%
2-chloro-5-fluoropyridine
31301-51-6

2-chloro-5-fluoropyridine

2-chloro-4-iodo-5-fluoropyridine
884494-49-9

2-chloro-4-iodo-5-fluoropyridine

Conditions
ConditionsYield
Stage #1: 2-chloro-5-fluoropyridine With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 2h; Inert atmosphere;
Stage #2: With iodine In tetrahydrofuran for 1h;
70%
Stage #1: 2-chloro-5-fluoropyridine With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 3h; Inert atmosphere;
Stage #2: With iodine In tetrahydrofuran at -78℃; for 1h;
60%
Stage #1: 2-chloro-5-fluoropyridine With tert.-butyl lithium In tetrahydrofuran; pentane at -78℃; for 2h; Inert atmosphere;
Stage #2: With iodine In tetrahydrofuran; pentane
39%
2-chloro-5-fluoropyridine
31301-51-6

2-chloro-5-fluoropyridine

2-chloro-5-fluoropyridin-4-ol

2-chloro-5-fluoropyridin-4-ol

Conditions
ConditionsYield
Stage #1: 2-chloro-5-fluoropyridine With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 2.5h; Inert atmosphere;
Stage #2: With Trimethyl borate In tetrahydrofuran at -78 - 20℃; for 2.33333h; Inert atmosphere;
Stage #3: With dihydrogen peroxide; acetic acid In tetrahydrofuran at 0 - 20℃; Inert atmosphere;
68%
2-chloro-5-fluoropyridine
31301-51-6

2-chloro-5-fluoropyridine

(RS)-2-(4-fluorophenyl)piperazine
65709-33-3

(RS)-2-(4-fluorophenyl)piperazine

C15H15F2N3

C15H15F2N3

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); X-Phos; sodium t-butanolate In 1,4-dioxane at 80℃; for 2h; Inert atmosphere; Microwave irradiation;67%
With tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; XPhos In 1,4-dioxane at 80℃; for 2h; Inert atmosphere; Microwave irradiation;67%
2-chloro-5-fluoropyridine
31301-51-6

2-chloro-5-fluoropyridine

C11H13BrMgO2*ClLi

C11H13BrMgO2*ClLi

4-(5-fluoropyridin-2-yl)phenyl pivalate

4-(5-fluoropyridin-2-yl)phenyl pivalate

Conditions
ConditionsYield
With chromium dichloride In tetrahydrofuran at 25℃; for 0.25h; Inert atmosphere;66%
4-carbethoxypiperidine
1126-09-6

4-carbethoxypiperidine

2-chloro-5-fluoropyridine
31301-51-6

2-chloro-5-fluoropyridine

1-(5-fluoropyridin-2-yl)piperidine-4-carboxylic acid ethyl
1310820-59-7

1-(5-fluoropyridin-2-yl)piperidine-4-carboxylic acid ethyl

Conditions
ConditionsYield
With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 75℃; for 2h;65%
With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 75℃; for 2h;65%
benzoimidazole
51-17-2

benzoimidazole

2-chloro-5-fluoropyridine
31301-51-6

2-chloro-5-fluoropyridine

2-chloro-5-(1H-benzimidazol-1-yl)pyridine

2-chloro-5-(1H-benzimidazol-1-yl)pyridine

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 70℃; for 24h; Inert atmosphere;65%
2-chloro-5-fluoropyridine
31301-51-6

2-chloro-5-fluoropyridine

N-tert-butoxycarbonyl-proline
15761-39-4

N-tert-butoxycarbonyl-proline

tert-butyl 2-(5-fluoropyridin-2-yl)pyrrolidine-1-carboxylate

tert-butyl 2-(5-fluoropyridin-2-yl)pyrrolidine-1-carboxylate

Conditions
ConditionsYield
With (1,2-dimethoxyethane)dichloronickel(II); [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; caesium carbonate; 4,4'-di-tert-butyl-2,2'-bipyridine In N,N-dimethyl-formamide at 23℃; Irradiation;64%
2-chloro-5-fluoropyridine
31301-51-6

2-chloro-5-fluoropyridine

6,6'-dichloro-3,3'-difluoro-2,2'-bipyridine

6,6'-dichloro-3,3'-difluoro-2,2'-bipyridine

Conditions
ConditionsYield
Stage #1: 2-chloro-5-fluoropyridine With (2,2,6,6-tetramethylpiperidyl)2Mn*2MgCl2*4LiCl In tetrahydrofuran at 0℃; for 3h; Inert atmosphere; Schlenk technique;
Stage #2: With chloranil In tetrahydrofuran at -40℃; for 0.5h; Inert atmosphere; Schlenk technique;
64%
2-chloro-5-fluoropyridine
31301-51-6

2-chloro-5-fluoropyridine

2,6-diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate
1041026-70-3

2,6-diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate

tert-butyl 6-(5-fluoropyridin-2-yl)-2,6-diazaspiro[3.3]heptane-2-carboxylate

tert-butyl 6-(5-fluoropyridin-2-yl)-2,6-diazaspiro[3.3]heptane-2-carboxylate

Conditions
ConditionsYield
With (2-dicyclohexylphosphino-2',6'-diisopropoxy-1,1'-biphenyl)[2-(2'-amino-1,1'-biphenyl)]palladium(II) methanesulfonate; sodium t-butanolate In 1,4-dioxane at 120℃; for 5h;62.2%
2-chloro-5-fluoropyridine
31301-51-6

2-chloro-5-fluoropyridine

N-Methoxy-N-methylacetamide
78191-00-1

N-Methoxy-N-methylacetamide

1-(2-chloro-5-fluoropyridin-4-yl)ethan-1-one
736990-31-1

1-(2-chloro-5-fluoropyridin-4-yl)ethan-1-one

Conditions
ConditionsYield
Stage #1: 2-chloro-5-fluoropyridine With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h;
Stage #2: N-Methoxy-N-methylacetamide In tetrahydrofuran; hexane at -78 - 20℃; for 1h;
61%

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