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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

Ethyl indole-2-acetate Manufacturer/High quality/Best price/In stock

Cas:33588-64-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

Manufacturer supply Ethyl indole-2-acetate CAS 33588-64-6 with attractive price Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates,

Manufacturer supply Ethyl indole-2-acetate CAS 33588-64-6 with attractive price

Cas:33588-64-6

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply Indole-2-Aceticacid, Ethyl Ester

Cas:33588-64-6

Min.Order:1

Negotiable

Type:Other

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so

C12H13NO2 ETHYL INDOLE-2-ACETATE 33588-64-6

Cas:33588-64-6

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 33588-64-6 with competitive price

Cas:33588-64-6

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Ethyl indole-2-acetate 33588-64-6

Cas:33588-64-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

ETHYL INDOLE-2-ACETATE CAS:33588-64-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic i

ETHYL INDOLE-2-ACETATE CAS:33588-64-6

Cas:33588-64-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Ethyl indole-2-acetate

Cas:33588-64-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:33588-64-6

Cas:33588-64-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

Indole-2-aceticacid, ethyl ester

Cas:33588-64-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Ethyl 2-(1H-indol-2-yl)acetate

Cas:33588-64-6

Min.Order:1 Gram

FOB Price: $879.0

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Ethylindole-2-acetate

Cas:33588-64-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Ethyl indole-2-acetate Manufacturer

Cas:33588-64-6

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

ETHYLINDOLE-2-ACETATE

Cas:33588-64-6

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: ETHYL INDOLE-2-ACETATE Synonyms: ETHYL INDOLE-2-ACETATE;ETHYL 1H-INDOL-2-YLACETATE;Ethyl2-indoleacetate;2-(1-ethyl-1H-indol-2-yl)acetate;Ethyl 2-(1H-indol-2-yl)acetate;Indol-2-ylacetic acid ethyl ester;Ethyl 2-(2-Indolyl)acetate;2

ETHYL INDOLE-2-ACETATE

Cas:33588-64-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

Ethyl 2-(1H-indol-2-yl)acetate

Cas:33588-64-6

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

Ethyl indole-2-acetate

Cas:33588-64-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Suzhou Sibian Chemical Technology Co., Ltd

The process is mature and can be mass produced to 100 kg, with good quality and purity up to 99%.The product has a large stock and can be supplied stably. Package:bottle Application:Drug R&D Transportation:Sealed drying(25℃) Port:ShangHai

Ethyl indole-2-acetate

Cas:33588-64-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

ETHYL INDOLE-2-ACETATE

Cas:33588-64-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

ethyl 2-indole acetate

Cas:33588-64-6

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

Ethyl 2-(1H-indol-2-yl)acetate

Cas:33588-64-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

ETHYL INDOLE-2-ACETATE

Cas:33588-64-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

Indole-2-Aceticacid, Ethyl Ester

Cas:33588-64-6

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Ethyl indole-2-acetate

Cas:33588-64-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Chemical intermediate

ethyl 2-(1H-indol-2-yl)acetate

Cas:33588-64-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

Ethyl indole-2-acetate cas 33588-64-6Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

Ethyl indole-2-acetate cas 33588-64-6

Cas:33588-64-6

Min.Order:0

Negotiable

Type:Other

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Best quality with low price Storage:ln stock Package:25kg/Barrel Application:Chemicals Transportation:Express/Sea/Air Port:Shanghai

ethyl 2-indoleacetate

Cas:33588-64-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

Ethyl indole-2-acetate

Cas:33588-64-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SAGECHEM LIMITED

33588-64-6 Application:intermediate

ethyl 2-indole acetate

Cas:33588-64-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hunan Russell Chemicals Technology Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

Ethyl 2-(1H-indol-2-yl)acetate 33588-64-6

Cas:33588-64-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

4-(2-nitrophenyl)-3-oxobutyric acid ethyl ester
66073-33-4

4-(2-nitrophenyl)-3-oxobutyric acid ethyl ester

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

Conditions
ConditionsYield
With ammonium chloride; zinc In tetrahydrofuran for 2h;95%
With palladium 10% on activated carbon; hydrogen In ethanol at 25℃; under 760.051 Torr; for 20h; Catalytic behavior; Reagent/catalyst; Solvent;91%
With ammonium acetate; titanium(III) chloride In acetone for 0.116667h;75%
(E)-4-[2-(1,1,1,3,3,3-Hexamethyl-disilazan-2-yl)-phenyl]-but-2-enoic acid ethyl ester
126742-92-5

(E)-4-[2-(1,1,1,3,3,3-Hexamethyl-disilazan-2-yl)-phenyl]-but-2-enoic acid ethyl ester

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In tetrahydrofuran at 25℃; for 0.166667h;88%
2,2-dimethyl-5-[2-(2-nitrophenyl)acetyl]-1,3-dioxane-4,6-dione

2,2-dimethyl-5-[2-(2-nitrophenyl)acetyl]-1,3-dioxane-4,6-dione

ethanol
64-17-5

ethanol

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

Conditions
ConditionsYield
Stage #1: 2,2-dimethyl-5-[2-(2-nitrophenyl)acetyl]-1,3-dioxane-4,6-dione; ethanol for 5h; Reflux; Inert atmosphere;
Stage #2: With ammonium chloride; zinc In tetrahydrofuran at 60℃; for 12h;
88%
(Z)-ethyl 3-(2-iodophenylamino)-but-2-enoate
128942-81-4

(Z)-ethyl 3-(2-iodophenylamino)-but-2-enoate

A

ethyl 2-methyl-1H-indole-3-carboxylate
53855-47-3

ethyl 2-methyl-1H-indole-3-carboxylate

B

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); silver orthophosphate In dimethyl sulfoxide at 100℃; for 3.5h; Heck reaction;A 79%
B 17%
triphenyl((ethyl(2-carbamoyl)acetate)-2-benzyl)phosphonium bromide
101315-54-2

triphenyl((ethyl(2-carbamoyl)acetate)-2-benzyl)phosphonium bromide

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

Conditions
ConditionsYield
With potassium tert-butylate In toluene for 0.75h; Heating / reflux;78%
With potassium tert-butylate In hexane; ethyl acetate; toluene78%
With potassium tert-butylate In toluene for 0.75h; Reflux;78%
With potassium tert-butylate In toluene for 0.25h; Heating;72%
With potassium tert-butylate In toluene for 0.25h; Heating;70%
indole
120-72-9

indole

ethyl bromoacetate
105-36-2

ethyl bromoacetate

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

Conditions
ConditionsYield
With silver fluoride In ethanol at 20℃; for 6h; Irradiation; Inert atmosphere;65%
With norborn-2-ene; bis(benzonitrile)palladium(II) dichloride; sodium hydrogencarbonate In water; N,N-dimethyl-formamide at 70℃; for 18h; Sealed tube; Inert atmosphere;57%
With tris[2-phenylpyridinato-C2,N]iridium(III); sodium hydrogencarbonate In water; acetonitrile for 18h; Schlenk technique; Inert atmosphere; Irradiation;55%
Ethyl 4-(2-nitrophenyl)but-2-enoate

Ethyl 4-(2-nitrophenyl)but-2-enoate

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In ethanol at 20℃; for 24h;62%
indole
120-72-9

indole

ethyl 2-(ethoxythiocarbonylthio)acetate
3278-34-0

ethyl 2-(ethoxythiocarbonylthio)acetate

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

Conditions
ConditionsYield
With dilauryl peroxide In 1,2-dichloro-ethane for 12h; Heating;60%
With triethyl borane; iron(II) sulfate In tetrahydrofuran; ethanol; dichloromethane at 20℃;30%
With tris[2-phenylpyridinato-C2,N]iridium(III); N,N-dimethyl-formamide at 24℃; Minisci Aromatic Substitution; Inert atmosphere; UV-irradiation; regioselective reaction;23%
diazoacetic acid ethyl ester
623-73-4

diazoacetic acid ethyl ester

indole
120-72-9

indole

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

Conditions
ConditionsYield
With tris(bipyridine)ruthenium(II) dichloride hexahydrate In methanol; dichloromethane; water Sealed tube; Irradiation; Cooling with ice; regioselective reaction;53%
indole
120-72-9

indole

ethyl iodoacetae
623-48-3

ethyl iodoacetae

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

Conditions
ConditionsYield
With tetrabutylammomium bromide; sodium thiosulfate; methyloxirane In various solvent(s) at 40℃; Substitution; Photolysis;36%
ethyl 2,3-butadienoate
14369-81-4

ethyl 2,3-butadienoate

C-(4-oxo-4H<1>benzopyran-3-yl)-N-phenylnitrone
113326-75-3

C-(4-oxo-4H<1>benzopyran-3-yl)-N-phenylnitrone

A

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

B

1-ethoxycarbonyl-3-(2'-hydroxybenzoyl)-benzo[b]-indolizine

1-ethoxycarbonyl-3-(2'-hydroxybenzoyl)-benzo[b]-indolizine

Conditions
ConditionsYield
In benzene for 22h; Heating;A 5%
B 35%
ethyl 2,3-butadienoate
14369-81-4

ethyl 2,3-butadienoate

C-(4-oxo-4H<1>benzopyran-3-yl)-N-phenylnitrone
113326-75-3

C-(4-oxo-4H<1>benzopyran-3-yl)-N-phenylnitrone

A

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

B

4-oxo-2-(N-phenyl)amino-4H-chromene-3-carbaldehyde
213273-03-1

4-oxo-2-(N-phenyl)amino-4H-chromene-3-carbaldehyde

C

1-ethoxycarbonyl-3-(2'-hydroxybenzoyl)-benzo[b]-indolizine

1-ethoxycarbonyl-3-(2'-hydroxybenzoyl)-benzo[b]-indolizine

Conditions
ConditionsYield
In benzene for 22h; Mechanism; Reactivity; Time; Reflux; regioselective reaction;A n/a
B n/a
C 35%
ethyl 2,3-butadienoate
14369-81-4

ethyl 2,3-butadienoate

C17H13NO3
213273-02-0

C17H13NO3

A

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

B

1-ethoxycarbonyl-3-(2'-hydroxy-5'-methyl-benzoyl)-benzo[b]indolizine
1168003-46-0

1-ethoxycarbonyl-3-(2'-hydroxy-5'-methyl-benzoyl)-benzo[b]indolizine

C

6-Methyl-4-oxo-2-phenylamino-4H-chromene-3-carbaldehyde
213273-05-3

6-Methyl-4-oxo-2-phenylamino-4H-chromene-3-carbaldehyde

Conditions
ConditionsYield
In benzene for 21h; Mechanism; Reactivity; Time; Reflux; regioselective reaction;A n/a
B 32%
C n/a
ethyl 2,3-butadienoate
14369-81-4

ethyl 2,3-butadienoate

C16H10ClNO3
213273-01-9

C16H10ClNO3

A

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

B

1-ethoxycarbonyl-3-(2'-hydroxy-5'-chloro-benzoyl)-benzo[b]indolizine
1168003-50-6

1-ethoxycarbonyl-3-(2'-hydroxy-5'-chloro-benzoyl)-benzo[b]indolizine

C

2-anilino-6-chloro-3-formylchromone
213273-04-2

2-anilino-6-chloro-3-formylchromone

Conditions
ConditionsYield
In benzene for 20h; Mechanism; Reactivity; Time; Reflux; regioselective reaction;A n/a
B 29%
C n/a
2-indol-2-yl-acetimidic acid ethyl ester; hydrochloride
108629-63-6

2-indol-2-yl-acetimidic acid ethyl ester; hydrochloride

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

Conditions
ConditionsYield
With water
indole
120-72-9

indole

ethyl iodoacetae
623-48-3

ethyl iodoacetae

A

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

B

ethyl 3-indoleacetate
778-82-5

ethyl 3-indoleacetate

Conditions
ConditionsYield
With dihydrogen peroxide; iron(II) sulfate In dimethyl sulfoxide Product distribution; Ambient temperature; intramolecular selectivity, further with thiophene, pyrrole, N-methylpyrrole, furan, ICH2CN, BrCH(CO2Et)2;
ethyl-1,2,3,5-tetrahydro-4-oxo-2-phenyl-4H-1-benzazepine-3-carboxylate
113373-69-6

ethyl-1,2,3,5-tetrahydro-4-oxo-2-phenyl-4H-1-benzazepine-3-carboxylate

C,N-diphenylnitrone
201024-81-9

C,N-diphenylnitrone

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

Conditions
ConditionsYield
With water In tetrahydrofuran at 20℃; for 24h; Yield given;
2-Aminobenzyl alcohol
5344-90-1

2-Aminobenzyl alcohol

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 88 percent / acetonitrile / 7 h / Heating
2: 71 percent / CH2Cl2 / 3 h
3: 70 percent / t-BuOK / toluene / 0.25 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: hexane; acetonitrile
2: ethanol; hexane; dichloromethane
3: potassium tert-butylate / hexane; ethyl acetate; toluene
View Scheme
Multi-step reaction with 3 steps
1: acetonitrile / 3 h / Reflux
2: dichloromethane / 3 h / 20 °C
3: potassium tert-butylate / toluene / 0.75 h / Reflux
View Scheme
(2-aminobenzyl)triphenylphosphonium bromide
78133-84-3

(2-aminobenzyl)triphenylphosphonium bromide

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 71 percent / CH2Cl2 / 3 h
2: 70 percent / t-BuOK / toluene / 0.25 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: 60 percent / CH2Cl2 / 3 h
2: 72 percent / KOtBu / toluene / 0.25 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: ethanol; hexane; dichloromethane
2: potassium tert-butylate / hexane; ethyl acetate; toluene
View Scheme
Multi-step reaction with 2 steps
1: dichloromethane / 3 h / 20 °C
2: potassium tert-butylate / toluene / 0.75 h / Reflux
View Scheme
2-Aminobenzyl alcohol
5344-90-1

2-Aminobenzyl alcohol

potassium hydroxide

potassium hydroxide

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 88 percent / acetonitrile / 6 h / Heating
2: 60 percent / CH2Cl2 / 3 h
3: 72 percent / KOtBu / toluene / 0.25 h / Heating
View Scheme
ethyl 2,3-butadienoate
14369-81-4

ethyl 2,3-butadienoate

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 70 percent Spectr. / tetrahydrofuran / 48 h / 20 °C
2: water / tetrahydrofuran / 24 h / 20 °C
View Scheme
C,N-diphenylnitrone
201024-81-9

C,N-diphenylnitrone

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 70 percent Spectr. / tetrahydrofuran / 48 h / 20 °C
2: water / tetrahydrofuran / 24 h / 20 °C
View Scheme
1,1,1-Trimethyl-N-(2-methylphenyl)-N-(trimethylsilyl)silanamine
126742-78-7

1,1,1-Trimethyl-N-(2-methylphenyl)-N-(trimethylsilyl)silanamine

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 65 percent / NBS, AIBN / CCl4 / 7 h / Heating
3: 88 percent / Bu4NF / tetrahydrofuran / 0.17 h / 25 °C
View Scheme
2-bromomethyl-N,N-bis-trimethylsilylaniline
126742-80-1

2-bromomethyl-N,N-bis-trimethylsilylaniline

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
2: 88 percent / Bu4NF / tetrahydrofuran / 0.17 h / 25 °C
View Scheme
o-toluidine
95-53-4

o-toluidine

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 82 percent / BuLi / tetrahydrofuran; hexane / 3 h / 0 - 25 °C
2: 65 percent / NBS, AIBN / CCl4 / 7 h / Heating
4: 88 percent / Bu4NF / tetrahydrofuran / 0.17 h / 25 °C
View Scheme
(2-nitrophenyl)acetyl chloride
22751-23-1

(2-nitrophenyl)acetyl chloride

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: i-Pr2NEt / CH2Cl2 / 1) 0 deg C, 1h, 2) RT, 1h
2: Heating
3: 75 percent / aq. ammonium acetate, aq. TiCl3 / acetone / 0.12 h
View Scheme
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 0 - 25 °C / Inert atmosphere
2: 0.75 h / Reflux
3: palladium 10% on activated carbon; hydrogen / ethanol / 20 h / 25 °C / 760.05 Torr
View Scheme
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 0 - 25 °C / Inert atmosphere
2: 0.75 h / Reflux
3: palladium 10% on activated carbon; hydrogen; acetic acid; methanesulfonic acid / 25 - 50 °C / 760.05 Torr / Flow reactor
View Scheme
Multi-step reaction with 2 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C
2.1: 5 h / Reflux; Inert atmosphere
2.2: 12 h / 60 °C
View Scheme
2-(2-nitrophenyl)acetic acid
3740-52-1

2-(2-nitrophenyl)acetic acid

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: SOCl2 / 50 °C
2: i-Pr2NEt / CH2Cl2 / 1) 0 deg C, 1h, 2) RT, 1h
3: Heating
4: 75 percent / aq. ammonium acetate, aq. TiCl3 / acetone / 0.12 h
View Scheme
Multi-step reaction with 4 steps
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 25 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 0 - 25 °C / Inert atmosphere
3: 0.75 h / Reflux
4: palladium 10% on activated carbon; hydrogen / ethanol / 20 h / 25 °C / 760.05 Torr
View Scheme
Multi-step reaction with 4 steps
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 25 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 0 - 25 °C / Inert atmosphere
3: 0.75 h / Reflux
4: palladium 10% on activated carbon; hydrogen; acetic acid; methanesulfonic acid / 25 - 50 °C / 760.05 Torr / Flow reactor
View Scheme
Multi-step reaction with 3 steps
1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 4 h / 20 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C
3.1: 5 h / Reflux; Inert atmosphere
3.2: 12 h / 60 °C
View Scheme
2,2-dimethyl-5-(2-phenylacetyl)-1,3-dioxane-4,6-dione
74965-87-0

2,2-dimethyl-5-(2-phenylacetyl)-1,3-dioxane-4,6-dione

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Heating
2: 75 percent / aq. ammonium acetate, aq. TiCl3 / acetone / 0.12 h
View Scheme
ethyl 2-acetyl-3-oxo-4-(2-nitrophenyl)butanoate
61417-33-2

ethyl 2-acetyl-3-oxo-4-(2-nitrophenyl)butanoate

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ethanolic NH3
2: zinc; aqueous acetic acid
View Scheme
ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

tert-butyl 2-((ethoxycarbonyl)methyl)-1H-indole-1-carboxylate
172226-77-6

tert-butyl 2-((ethoxycarbonyl)methyl)-1H-indole-1-carboxylate

Conditions
ConditionsYield
With dmap In dichloromethane for 3h; Ambient temperature;100%
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 16h;97%
With dmap; triethylamine In dichloromethane at 20℃; for 14h;93%
With dmap In dichloromethane at 20℃; for 2h;91%
formaldehyd
50-00-0

formaldehyd

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

dimethyl amine
124-40-3

dimethyl amine

ethyl 3-[(dimethylamino)methyl]-1H-indole-2-acetate
252637-04-0

ethyl 3-[(dimethylamino)methyl]-1H-indole-2-acetate

Conditions
ConditionsYield
Substitution;95%
With acetic acid In water at 20℃; for 24h;41%
ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

acetyl chloride
75-36-5

acetyl chloride

ethyl 3-acetylindol-2-ylacetate
129410-13-5

ethyl 3-acetylindol-2-ylacetate

Conditions
ConditionsYield
With tin(IV) chloride In dichloromethane for 60h; Ambient temperature;93%
ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

C8H9BrO3
1404575-81-0

C8H9BrO3

C19H18BrNO4

C19H18BrNO4

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In dichloromethane at 0℃; for 0.5h;93%
ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

5,6,6-trimethoxycyclohexa-2,4-dien-1-one
57197-26-9

5,6,6-trimethoxycyclohexa-2,4-dien-1-one

C20H21NO5

C20H21NO5

Conditions
ConditionsYield
With boron trifluoride diethyl etherate In dichloromethane at 0℃; for 0.5h;92%
ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

tert-butyldicarbonate
34619-03-9

tert-butyldicarbonate

tert-butyl 2-((ethoxycarbonyl)methyl)-1H-indole-1-carboxylate
172226-77-6

tert-butyl 2-((ethoxycarbonyl)methyl)-1H-indole-1-carboxylate

Conditions
ConditionsYield
With dmap In dichloromethane at 20℃; for 2h;91%
With dmap In hexane; dichloromethane; ethyl acetate91%
N-phenyl-maleimide
941-69-5

N-phenyl-maleimide

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

3-nitro-benzaldehyde
99-61-6

3-nitro-benzaldehyde

(3aSR,4RS,10SR,10aSR)-10-(3-nitrophenyl)-1,3-dioxo-2-phenyl-1,2,3,3a,4,5,10,10a-octahydropyrrolo[3,4-b]carbazole-4-carboxylic acid ethyl ester

(3aSR,4RS,10SR,10aSR)-10-(3-nitrophenyl)-1,3-dioxo-2-phenyl-1,2,3,3a,4,5,10,10a-octahydropyrrolo[3,4-b]carbazole-4-carboxylic acid ethyl ester

Conditions
ConditionsYield
With copper(II) sulfate In toluene at 130℃; for 18h;90%
ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

edaravone
89-25-8

edaravone

ethyl 2-(4-methoxyphenyl)-3'-methyl-5'-oxo-1'-phenyl-1',5'-dihydro-4H-spiro[cyclopenta[b]indole-1,4'-pyrazole]-3-carboxylate

ethyl 2-(4-methoxyphenyl)-3'-methyl-5'-oxo-1'-phenyl-1',5'-dihydro-4H-spiro[cyclopenta[b]indole-1,4'-pyrazole]-3-carboxylate

Conditions
ConditionsYield
Stage #1: ethyl 2-(1H-indol-2-yl)acetate; 4-methoxy-benzaldehyde; edaravone With copper(II) sulfate In toluene at 130℃; for 0.3h;
Stage #2: With 2,3-dicyano-5,6-dichloro-p-benzoquinone In acetonitrile at 20℃; for 4h; diastereoselective reaction;
90%
ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

phenylacetylene
536-74-3

phenylacetylene

ethyl 2-(3-(1-phenylvinyl)-1H-indol-2-yl)acetate

ethyl 2-(3-(1-phenylvinyl)-1H-indol-2-yl)acetate

Conditions
ConditionsYield
With bis[(trifluoromethanesulfonyl)imidate]-2-(dicyclohexyl(2’,6’-dimethoxybiphenyl))phosphine gold(I) In acetonitrile at 50℃; for 24h;89%
ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

3-Chlorobenzaldehyde
587-04-2

3-Chlorobenzaldehyde

edaravone
89-25-8

edaravone

ethyl 2-(3-chlorophenyl)-3'-methyl-5'-oxo-1'-phenyl-1',5'-dihydro-4H-spiro[cyclopenta[b]indole-1,4'-pyrazole]-3-carboxylate

ethyl 2-(3-chlorophenyl)-3'-methyl-5'-oxo-1'-phenyl-1',5'-dihydro-4H-spiro[cyclopenta[b]indole-1,4'-pyrazole]-3-carboxylate

Conditions
ConditionsYield
Stage #1: ethyl 2-(1H-indol-2-yl)acetate; m-Chlorobenzaldehyde; edaravone With copper(II) sulfate In toluene at 130℃; for 0.3h;
Stage #2: With 2,3-dicyano-5,6-dichloro-p-benzoquinone In acetonitrile at 20℃; for 4h; diastereoselective reaction;
87%
ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

C13H17BrO2

C13H17BrO2

ethyl 3-(4-bromophenyl)-9H-carbazole-1-carboxylate

ethyl 3-(4-bromophenyl)-9H-carbazole-1-carboxylate

Conditions
ConditionsYield
With N-Bromosuccinimide; aluminium(III) triflate In 1,4-dioxane at 80℃; for 0.5h; Green chemistry;86%
ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

edaravone
89-25-8

edaravone

ethyl 2-(4-chlorophenyl)-3'-methyl-5'-oxo-1'-phenyl-1',5'-dihydro-4H-spiro[cyclopenta[b]indole-1,4'-pyrazole]-3-carboxylate

ethyl 2-(4-chlorophenyl)-3'-methyl-5'-oxo-1'-phenyl-1',5'-dihydro-4H-spiro[cyclopenta[b]indole-1,4'-pyrazole]-3-carboxylate

Conditions
ConditionsYield
Stage #1: ethyl 2-(1H-indol-2-yl)acetate; 4-chlorobenzaldehyde; edaravone With copper(II) sulfate In toluene at 130℃; for 0.3h;
Stage #2: With 2,3-dicyano-5,6-dichloro-p-benzoquinone In acetonitrile at 20℃; for 4h; diastereoselective reaction;
85%
ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

4-fluorobenzaldehyde
459-57-4

4-fluorobenzaldehyde

edaravone
89-25-8

edaravone

ethyl 2-(4-fluorophenyl)-3'-methyl-5'-oxo-1'-phenyl-1',5'-dihydro-4H-spiro[cyclopenta[b]indole-1,4'-pyrazole]-3-carboxylate

ethyl 2-(4-fluorophenyl)-3'-methyl-5'-oxo-1'-phenyl-1',5'-dihydro-4H-spiro[cyclopenta[b]indole-1,4'-pyrazole]-3-carboxylate

Conditions
ConditionsYield
Stage #1: ethyl 2-(1H-indol-2-yl)acetate; 4-fluorobenzaldehyde; edaravone With copper(II) sulfate In toluene at 130℃; for 0.3h;
Stage #2: With 2,3-dicyano-5,6-dichloro-p-benzoquinone In acetonitrile at 20℃; for 4h; diastereoselective reaction;
85%
ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

4-methyl-benzaldehyde
104-87-0

4-methyl-benzaldehyde

1,3-cylohexanedione
504-02-9

1,3-cylohexanedione

ethyl rel-(1S,2R,4S)-2',6'-dioxo-2,4-di-p-tolyl-1,2,4,9-tetrahydrospiro[carbazole-3,1'-cyclohexane]-1-carboxylate

ethyl rel-(1S,2R,4S)-2',6'-dioxo-2,4-di-p-tolyl-1,2,4,9-tetrahydrospiro[carbazole-3,1'-cyclohexane]-1-carboxylate

Conditions
ConditionsYield
With copper(II) sulfate In toluene at 110℃; for 3h; Diels-Alder Cycloaddition; Green chemistry; diastereoselective reaction;84%
ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

ethyl 2-(2,3-dihydro-1H-indole-2-yl)acetate
64132-03-2

ethyl 2-(2,3-dihydro-1H-indole-2-yl)acetate

Conditions
ConditionsYield
With borane; trimethylamine In trifluoroacetic acid82%
With trimethylamine-borane; trifluoroacetic acid for 0.25h;82%
With sodium cyanoborohydride; acetic acid82%
ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

4-(4-methylbenzylidene)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
53316-56-6

4-(4-methylbenzylidene)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one

4-nitrobenzaldehdye
555-16-8

4-nitrobenzaldehdye

ethyl rel-(1R,2S,3R,4R)-3'-methyl-4-(4-nitrophenyl)-5'-oxo-1'-phenyl-2-(p-tolyl)-1,1',2,4,5',9-hexahydrospiro[carbazole-3,4'-pyrazole]-1-carboxylate

ethyl rel-(1R,2S,3R,4R)-3'-methyl-4-(4-nitrophenyl)-5'-oxo-1'-phenyl-2-(p-tolyl)-1,1',2,4,5',9-hexahydrospiro[carbazole-3,4'-pyrazole]-1-carboxylate

Conditions
ConditionsYield
With copper(II) sulfate In toluene at 130℃; for 0.3h; diastereoselective reaction;82%
2-phenyl-thiazol-4-one
827-46-3

2-phenyl-thiazol-4-one

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

4-nitrobenzaldehdye
555-16-8

4-nitrobenzaldehdye

ethyl rel-(1S,2R,3S,4S)-2,4-bis(4-nitrophenyl)-4'-oxo-2'-phenyl-1,2,4,9-tetrahydro-4'H-spiro[carbazole-3,5'-thiazole]-1-carboxylate

ethyl rel-(1S,2R,3S,4S)-2,4-bis(4-nitrophenyl)-4'-oxo-2'-phenyl-1,2,4,9-tetrahydro-4'H-spiro[carbazole-3,5'-thiazole]-1-carboxylate

Conditions
ConditionsYield
With copper(II) sulfate In toluene at 130℃; for 0.3h; diastereoselective reaction;82%
ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

1,3-cylohexanedione
504-02-9

1,3-cylohexanedione

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

ethyl rel-(1S,2R,4S)-2,4-bis(4-methoxyphenyl)-2',6'-dioxo-1,2,4,9-tetrahydrospiro[carbazole-3,1'-cyclohexane]-1-carboxylate

ethyl rel-(1S,2R,4S)-2,4-bis(4-methoxyphenyl)-2',6'-dioxo-1,2,4,9-tetrahydrospiro[carbazole-3,1'-cyclohexane]-1-carboxylate

Conditions
ConditionsYield
With copper(II) sulfate In toluene at 110℃; for 3h; Diels-Alder Cycloaddition; Green chemistry; diastereoselective reaction;82%
1,3-dimethylbarbituric acid
769-42-6

1,3-dimethylbarbituric acid

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

4-methyl-benzaldehyde
104-87-0

4-methyl-benzaldehyde

ethyl rel-(1R,2S,4R)-1',3'-dimethyl-2',4',6'-trioxo-2,4-di-p-tolyl-1,1',2,3',4,4',6',9-octahydro-2'H-spiro[carbazole-3,5'-pyrimidine]-1-carboxylate

ethyl rel-(1R,2S,4R)-1',3'-dimethyl-2',4',6'-trioxo-2,4-di-p-tolyl-1,1',2,3',4,4',6',9-octahydro-2'H-spiro[carbazole-3,5'-pyrimidine]-1-carboxylate

Conditions
ConditionsYield
With copper(II) sulfate In toluene at 110℃; for 3h; Diels-Alder Cycloaddition; Green chemistry; diastereoselective reaction;82%
ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

2,3,6,7-tetrahydro-3-isopropyl-2-(4-nitrophenyl)cyclo-penta[e][1,3]oxazin-4(5H)-one
25105-60-6

2,3,6,7-tetrahydro-3-isopropyl-2-(4-nitrophenyl)cyclo-penta[e][1,3]oxazin-4(5H)-one

ethyl 3-[1-[(1-methylethyl)amino]-1-(4-nitrophenyl)methyl]-1H-indole-2-acetate

ethyl 3-[1-[(1-methylethyl)amino]-1-(4-nitrophenyl)methyl]-1H-indole-2-acetate

Conditions
ConditionsYield
With acetic acid In toluene at 4℃; for 72h;81%
ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

1-chloro-4-(3,3-diethoxyprop-1-en-2-yl)benzene

1-chloro-4-(3,3-diethoxyprop-1-en-2-yl)benzene

ethyl 3-(4-chlorophenyl)-9H-carbazole-1-carboxylate

ethyl 3-(4-chlorophenyl)-9H-carbazole-1-carboxylate

Conditions
ConditionsYield
With N-Bromosuccinimide; aluminium(III) triflate In 1,4-dioxane at 80℃; for 0.5h; Green chemistry;81%
ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

2-phenylacrylaldehyde diethyl acetal
80234-04-4

2-phenylacrylaldehyde diethyl acetal

ethyl 3-phenyl-9H-carbazole-1-carboxylate

ethyl 3-phenyl-9H-carbazole-1-carboxylate

Conditions
ConditionsYield
With N-Bromosuccinimide; aluminium(III) triflate In 1,4-dioxane at 80℃; for 0.5h; Green chemistry;80%
ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

1,3-cylohexanedione
504-02-9

1,3-cylohexanedione

ethyl rel-(1S,2R,4S)-2,4-bis(4-chlorophenyl)-2',6'-dioxo-1,2,4,9-tetrahydrospiro[carbazole-3,1'-cyclohexane]-1-carboxylate

ethyl rel-(1S,2R,4S)-2,4-bis(4-chlorophenyl)-2',6'-dioxo-1,2,4,9-tetrahydrospiro[carbazole-3,1'-cyclohexane]-1-carboxylate

Conditions
ConditionsYield
With copper(II) sulfate In toluene at 110℃; for 3h; Diels-Alder Cycloaddition; Green chemistry; diastereoselective reaction;80%
1,3-dimethylbarbituric acid
769-42-6

1,3-dimethylbarbituric acid

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

ethyl rel-(1R,2S,4R)-2,4-bis(4-chlorophenyl)-1',3'-dimethyl-2',4',6'-trioxo-1,1',2,3',4,4',6',9-octahydro-2'H-spiro[carbazole-3,5'-pyrimidine]-1-carboxylate

ethyl rel-(1R,2S,4R)-2,4-bis(4-chlorophenyl)-1',3'-dimethyl-2',4',6'-trioxo-1,1',2,3',4,4',6',9-octahydro-2'H-spiro[carbazole-3,5'-pyrimidine]-1-carboxylate

Conditions
ConditionsYield
With copper(II) sulfate In toluene at 110℃; for 3h; Diels-Alder Cycloaddition; Green chemistry; diastereoselective reaction;80%
1,3-dimethylbarbituric acid
769-42-6

1,3-dimethylbarbituric acid

ethyl 2-(1H-indol-2-yl)acetate
33588-64-6

ethyl 2-(1H-indol-2-yl)acetate

m-tolyl aldehyde
620-23-5

m-tolyl aldehyde

ethyl rel-(1R,2S,4R)-1',3'-dimethyl-2',4',6'-trioxo-2,4-di-m-tolyl-1,1',2,3',4,4',6',9-octahydro-2'H-spiro[carbazole-3,5'-pyrimidine]-1-carboxylate

ethyl rel-(1R,2S,4R)-1',3'-dimethyl-2',4',6'-trioxo-2,4-di-m-tolyl-1,1',2,3',4,4',6',9-octahydro-2'H-spiro[carbazole-3,5'-pyrimidine]-1-carboxylate

ethyl rel-(1R,2S,4S)-1',3'-dimethyl-2',4',6'-trioxo-2,4-di-m-tolyl-1,1',2,3',4,4',6',9-octahydro-2'H-spiro[carbazole-3,5'-pyrimidine]-1-carboxylate

ethyl rel-(1R,2S,4S)-1',3'-dimethyl-2',4',6'-trioxo-2,4-di-m-tolyl-1,1',2,3',4,4',6',9-octahydro-2'H-spiro[carbazole-3,5'-pyrimidine]-1-carboxylate

Conditions
ConditionsYield
With copper(II) sulfate In toluene at 110℃; for 3h; Diels-Alder Cycloaddition; Green chemistry; diastereoselective reaction;A 77%
B n/a

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