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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

CHLOROMALONALDEHYDE

Cas:36437-19-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Chloromalonaldehyde

Cas:36437-19-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car

CHLOROMALONALDEHYDE

Cas:36437-19-1

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Factory supply 36437-19-1 2-CHLOROMALONALDEHYDE

Cas:36437-19-1

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

2-CHLOROMALONALDEHYDE CAS:36437-19-1 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic int

2-CHLOROMALONALDEHYDE CAS:36437-19-1

Cas:36437-19-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2-Chloromalonaldehyde

Cas:36437-19-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:36437-19-1

Cas:36437-19-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers 2. Produce products of different specifications and sizes according to your requirements. 3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures s

2-Chloromalonaldehyde

Cas:36437-19-1

Min.Order:1 Kilogram

FOB Price: $40.0 / 50.0

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-Chloromalonaldehyde

Cas:36437-19-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

Chloromalonaldehyde

Cas:36437-19-1

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

Factory supply 36437-19-1 2-CHLOROMALONALDEHYDE

Cas:36437-19-1

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate. In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so o

TIANFU CHEM 2-CHLOROMALONALDEHYDE

Cas:36437-19-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

CHLOROMALONALDEHYDE

Cas:36437-19-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

2-CHLOROMALONALDEHYDE Chemical Properties Melting point 140-145 °C Boiling point 111℃ density 1.261 refractive index 1.4100 (estimate) Fp 32℃ storage temp. Inert atmosphere,Store in freezer, under -20°C pka 1.48&plu

2-CHLOROMALONALDEHYDE

Cas:36437-19-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Factory supply 36437-19-1 2-CHLOROMALONALDEHYDE

Cas:36437-19-1

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

2-Chloromalonaldehyde

Cas:36437-19-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Factory supply 36437-19-1 2-CHLOROMALONALDEHYDE

Cas:36437-19-1

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

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Shanghai Massive Chemical Technology Co., Ltd.

Shanghai Massive Chemical Technology Co., Ltd. is engaged in development, production and marketing Specialty Chemicals to satisfy the changing needs of the chemical industry. We specialize in manufacturing high quality of Advanced Intermediates, Sp

2-CHLOROMALONALDEHYDE

Cas:36437-19-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

Factory supply 36437-19-1 2-CHLOROMALONALDEHYDE

Cas:36437-19-1

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

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Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

2-Chloromalonaldehyde

Cas:36437-19-1

Min.Order:0

Negotiable

Type:Manufacturers

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Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

2-Chloromalonaldehyde

Cas:36437-19-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hubei Langyou International Trading Co., Ltd

Factory supply 36437-19-1 2-CHLOROMALONALDEHYDE Application:Factory supply 36437-19-1 2-CHLOROMALONALDEHYDE

Factory supply 36437-19-1 2-CHLOROMALONALDEHYDE

Cas:36437-19-1

Min.Order:0

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Type:Other

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Guangdong Juda Chemical Industrial Co.,Limited

Appearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

2-CHLOROMALONALDEHYDE CAS No.36437-19-1

Cas:36437-19-1

Min.Order:0

Negotiable

Type:Trading Company

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Hangzhou Fandachem Co.,Ltd

2-CHLOROMALONALDEHYDEAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

2-CHLOROMALONALDEHYDE

Cas:36437-19-1

Min.Order:0

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Type:Other

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Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

2-Chloromalonaldehyde

Cas:36437-19-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou ZeErRui Chemical Co., Ltd.

Hangzhou ZeErRui Chemical Co., Ltd. is focused on customization, research and development and production of APIs and advanced intermediates, which can effectively compensate for the deficiencies of traditional CRO and CMO. Priority of high-tech barri

2-CHLOROMALONALDEHYDE

Cas:36437-19-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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SAGECHEM LIMITED

36437-19-1 Application:intermediate

2-Chloromalonaldehyde

Cas:36437-19-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hunan Longxianng Runhui Trading Co.,Ltd

Factory supply 36437-19-1 2-CHLOROMALONALDEHYDEAppearance:powder Storage:keep dry Package:25kg/bag or follow your requirement Application:raw material Transportation:By express (Door to door) such as FEDEX, DHL, EMS for small amount. By air(airport t

Factory supply 36437-19-1 2-CHLOROMALONALDEHYDE

Cas:36437-19-1

Min.Order:0

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Type:Lab/Research institutions

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Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

36437-19-1

Cas:36437-19-1

Min.Order:0

Negotiable

Type:Trading Company

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Saiwante (shanghai) New Material Technology Co., Ltd.

Stable supply of goods and provision of high-quality services Application:As raw materials in the field of medicine and biology

Factory supply 36437-19-1 2-CHLOROMALONALDEHYDE

Cas:36437-19-1

Min.Order:0

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Synthetic route

malondialdehyde bis(diethyl acetal)
122-31-6

malondialdehyde bis(diethyl acetal)

2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

Conditions
ConditionsYield
With phosphorus pentachloride anschliessend Behandeln mit Sulfurylchlorid unter Zusatz von Dibenzoylperoxid und Schuetteln mit wss.Natriumcarbonat-Loesung;
1,2,3,3-tetrachloro-1-propene
20589-85-9

1,2,3,3-tetrachloro-1-propene

2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

Conditions
ConditionsYield
With sulfuric acid
With sulfuric acid at 30 - 40℃;
5-tert-butoxy-6-chloro-2,3-dihydro-5H-[1,4]dioxepine
65041-41-0

5-tert-butoxy-6-chloro-2,3-dihydro-5H-[1,4]dioxepine

2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane Ambient temperature;
7,7-dichloro-2,5-dioxybicyclo <4.1.0> heptane
53923-47-0

7,7-dichloro-2,5-dioxybicyclo <4.1.0> heptane

2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

Conditions
ConditionsYield
With acetic acid Heating;
1,2,3,3-tetrachloro-1-propene
20589-85-9

1,2,3,3-tetrachloro-1-propene

sulfuric acid
7664-93-9

sulfuric acid

2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

Conditions
ConditionsYield
at 30 - 40℃;
trimethylene glycol diacetate

trimethylene glycol diacetate

2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

Conditions
ConditionsYield
With chlorine Irradiation.durch UV bei Raumtemperatur und 4-stdg. Erwaermen des Chlorierungsprodukts mit Aethanol oder laengeres Behandeln mit konz. H2SO4, zuletzt bei 40grad;
3-anilino-2-chloro-acrylaldehyde
131139-84-9

3-anilino-2-chloro-acrylaldehyde

acid

acid

A

2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

B

aniline
62-53-3

aniline

3-anilino-2-chloro-acrylaldehyde
131139-84-9

3-anilino-2-chloro-acrylaldehyde

alkali

alkali

A

2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

B

aniline
62-53-3

aniline

3-benzoyloxy-2-chloro-acrylaldehyde

3-benzoyloxy-2-chloro-acrylaldehyde

alcoholic potash

alcoholic potash

A

2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

B

benzoic acid
65-85-0

benzoic acid

C10H15NO2S
951330-88-4

C10H15NO2S

2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

C13H15NO3S

C13H15NO3S

Conditions
ConditionsYield
With sodium hydrogencarbonate In tetrahydrofuran at 50℃; for 14h;94%
2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

3-amino-2-chloroacrolein

3-amino-2-chloroacrolein

Conditions
ConditionsYield
With ammonium hydroxide93%
2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

4-chlorothiobenzamide
2521-24-6

4-chlorothiobenzamide

2-(4-chloro-phenyl)-thiazole-5-carbaldehyde
721920-84-9

2-(4-chloro-phenyl)-thiazole-5-carbaldehyde

Conditions
ConditionsYield
With basic magnesium carbonate In water at 60℃; for 3h;92%
With magnesium carbonate hexahydrate In 1,2-dimethoxyethane at 60℃; for 3h; Inert atmosphere;
(3-amino-1H-1,2,4-triazol-5-yl)methanol
27277-03-8

(3-amino-1H-1,2,4-triazol-5-yl)methanol

2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

(6-chloro-[1,2,4]triazolo[1,5-a]pyrimidine-2-yl)methanol
749929-28-0

(6-chloro-[1,2,4]triazolo[1,5-a]pyrimidine-2-yl)methanol

Conditions
ConditionsYield
In acetic acid at 80℃; for 4h;92%
2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

5-(2-fluoro-5-nitrophenyl)-4H-1,2,4-triazol-3-amine

5-(2-fluoro-5-nitrophenyl)-4H-1,2,4-triazol-3-amine

C11H5ClFN5O2

C11H5ClFN5O2

Conditions
ConditionsYield
With acetic acid at 120℃; for 3h;87.7%
2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

Chloromalondialdehyd-kaliumsalz

Chloromalondialdehyd-kaliumsalz

Conditions
ConditionsYield
With potassium hydroxide In water ice-cooled, pH 9;85%
2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

(1,4-dihydro-4,4-dimethyl-2-oxo-2H-3,1-benzoxazin-6-yl)boronic acid
304853-90-5

(1,4-dihydro-4,4-dimethyl-2-oxo-2H-3,1-benzoxazin-6-yl)boronic acid

6-(4-chloro-1H-pyrazol-1-yl)-4,4-dimethyl-1H-benzo[d][1,3]oxazin-2(4H)-one
1248589-27-6

6-(4-chloro-1H-pyrazol-1-yl)-4,4-dimethyl-1H-benzo[d][1,3]oxazin-2(4H)-one

Conditions
ConditionsYield
Stage #1: (1,4-dihydro-4,4-dimethyl-2-oxo-2H-3,1-benzoxazin-6-yl)boronic acid With di-tert-butyl-diazodicarboxylate; copper(II) acetate monohydrate In methanol at 65℃; for 1h;
Stage #2: 2-chloromalonaldehyde With hydrogenchloride In 1,4-dioxane; methanol at 20 - 80℃;
78%
2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

bromopentafluorobenzene
344-04-7

bromopentafluorobenzene

4-chloro-1-(perfluorophenyl)-1H-pyrazole
1152719-80-6

4-chloro-1-(perfluorophenyl)-1H-pyrazole

Conditions
ConditionsYield
Stage #1: bromopentafluorobenzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h;
Stage #2: With di-tert-butyl-diazodicarboxylate In tetrahydrofuran; hexane at -78 - 23℃; for 0.5h;
Stage #3: 2-chloromalonaldehyde With hydrogenchloride In tetrahydrofuran; 1,4-dioxane; hexane at 80℃; for 0.166667h;
75%
2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

p-trifluoromethylphenyl bromide
402-43-7

p-trifluoromethylphenyl bromide

4-chloro-1-(4-(trifluoromethyl)phenyl)-1H-pyrazole
1152719-79-3

4-chloro-1-(4-(trifluoromethyl)phenyl)-1H-pyrazole

Conditions
ConditionsYield
Stage #1: p-trifluoromethylphenyl bromide With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h;
Stage #2: With di-tert-butyl-diazodicarboxylate In tetrahydrofuran; hexane at -78 - 23℃; for 0.5h;
Stage #3: 2-chloromalonaldehyde With hydrogenchloride In tetrahydrofuran; 1,4-dioxane; hexane at 80℃; for 0.166667h;
75%
2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

2-methylphenyl bromide
95-46-5

2-methylphenyl bromide

4-chloro-1-(o-tolyl)-1H-pyrazole
1152719-75-9

4-chloro-1-(o-tolyl)-1H-pyrazole

Conditions
ConditionsYield
Stage #1: 2-methylphenyl bromide With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h;
Stage #2: With di-tert-butyl-diazodicarboxylate In tetrahydrofuran; hexane at -78 - 23℃; for 0.5h;
Stage #3: 2-chloromalonaldehyde With hydrogenchloride In tetrahydrofuran; 1,4-dioxane; hexane at 80℃; for 0.166667h;
73%
5-bromo-2-chloropyridine
53939-30-3

5-bromo-2-chloropyridine

2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

2-chloro-5-(4-chloro-1H-pyrazol-1-yl)pyridine
1152719-84-0

2-chloro-5-(4-chloro-1H-pyrazol-1-yl)pyridine

Conditions
ConditionsYield
Stage #1: 5-bromo-2-chloropyridine With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h;
Stage #2: With di-tert-butyl-diazodicarboxylate In tetrahydrofuran; hexane at -78 - 23℃; for 0.5h;
Stage #3: 2-chloromalonaldehyde With hydrogenchloride In tetrahydrofuran; 1,4-dioxane; hexane at 80℃; for 0.166667h;
67%
2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

Dichloromalondialdehyd
77084-28-7

Dichloromalondialdehyd

Conditions
ConditionsYield
With chlorine In dichloromethane at 5℃; 1.) 5 deg C, 2.) r.t., 1 h;64%
2-bromo-6-methylpyridine
5315-25-3

2-bromo-6-methylpyridine

2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

2-(4-chloro-1H-pyrazol-1-yl)-6-methylpyridine
1152719-82-8

2-(4-chloro-1H-pyrazol-1-yl)-6-methylpyridine

Conditions
ConditionsYield
Stage #1: 2-bromo-6-methylpyridine With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h;
Stage #2: With di-tert-butyl-diazodicarboxylate In tetrahydrofuran; hexane at -78 - 23℃; for 0.5h;
Stage #3: 2-chloromalonaldehyde With hydrogenchloride In tetrahydrofuran; 1,4-dioxane; hexane at 80℃; for 0.166667h;
64%
2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

4-fluoro-1-iodobenzene
352-34-1

4-fluoro-1-iodobenzene

4-chloro-1-(4-fluorophenyl)-1H-pyrazole
1152719-73-7

4-chloro-1-(4-fluorophenyl)-1H-pyrazole

Conditions
ConditionsYield
Stage #1: 4-fluoro-1-iodobenzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h;
Stage #2: With di-tert-butyl-diazodicarboxylate In tetrahydrofuran; hexane at -78 - 23℃; for 0.5h;
Stage #3: 2-chloromalonaldehyde With hydrogenchloride In tetrahydrofuran; 1,4-dioxane; hexane at 80℃; for 0.166667h;
64%
2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

tert-butyl (S)-(1-amino-1-thioxopropan-2-yl)carbamate
141041-86-3, 96929-01-0, 140903-30-6

tert-butyl (S)-(1-amino-1-thioxopropan-2-yl)carbamate

tert-butyl 1-(5-formylthiazol-2-yl)ethylcarbamate
1332873-08-1

tert-butyl 1-(5-formylthiazol-2-yl)ethylcarbamate

Conditions
ConditionsYield
With magnesium carbonate In 1,4-dioxane at 60℃; for 3h;64%
2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

C12H13BrF2O2
1152719-91-9

C12H13BrF2O2

1-(3-bromo-5-(5,5-dimethyl-1,3-dioxan-2-yl)-2,6-difluorophenyl)-4-chloro-1H-pyrazole
1152719-86-2

1-(3-bromo-5-(5,5-dimethyl-1,3-dioxan-2-yl)-2,6-difluorophenyl)-4-chloro-1H-pyrazole

Conditions
ConditionsYield
Stage #1: C12H13BrF2O2 With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.5h;
Stage #2: With di-tert-butyl-diazodicarboxylate In tetrahydrofuran at -78 - 23℃; for 0.5h;
Stage #3: 2-chloromalonaldehyde With hydrogenchloride In tetrahydrofuran; 1,4-dioxane; hexane at 100℃; for 0.0833333h;
61%
2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

C18H24BrF2NO3
1152719-89-5

C18H24BrF2NO3

(2R,6R)-4-(4-(4-chloro-1H-pyrazol-1-yl)-6-(5,5-dimethyl-1,3-dioxan-2-yl)-2,3-difluorophenyl)-2,6-dimethylmorpholine
1152719-72-6

(2R,6R)-4-(4-(4-chloro-1H-pyrazol-1-yl)-6-(5,5-dimethyl-1,3-dioxan-2-yl)-2,3-difluorophenyl)-2,6-dimethylmorpholine

Conditions
ConditionsYield
Stage #1: C18H24BrF2NO3 With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h;
Stage #2: With di-tert-butyl-diazodicarboxylate In tetrahydrofuran; hexane at -78 - 20℃; for 0.583333h;
Stage #3: 2-chloromalonaldehyde With hydrogenchloride In tetrahydrofuran; hexane; water at 100℃; for 0.0833333h;
60%
3-methoxyphenyl bromide
2398-37-0

3-methoxyphenyl bromide

2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

4-chloro-1-(3-methoxyphenyl)-1H-pyrazole
1152719-76-0

4-chloro-1-(3-methoxyphenyl)-1H-pyrazole

Conditions
ConditionsYield
Stage #1: 3-methoxyphenyl bromide With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h;
Stage #2: With di-tert-butyl-diazodicarboxylate In tetrahydrofuran; hexane at -78 - 23℃; for 0.5h;
Stage #3: 2-chloromalonaldehyde With hydrogenchloride In tetrahydrofuran; 1,4-dioxane; hexane at 80℃; for 0.166667h;
60%
5-bromo-2-fluoropyridine
766-11-0

5-bromo-2-fluoropyridine

2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

5-(4-chloro-1H-pyrazol-1-yl)-2-fluoropyridine
1152719-83-9

5-(4-chloro-1H-pyrazol-1-yl)-2-fluoropyridine

Conditions
ConditionsYield
Stage #1: 5-bromo-2-fluoropyridine With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h;
Stage #2: With di-tert-butyl-diazodicarboxylate In tetrahydrofuran; hexane at -78 - 23℃; for 0.5h;
Stage #3: 2-chloromalonaldehyde With hydrogenchloride In tetrahydrofuran; 1,4-dioxane; hexane at 80℃; for 0.166667h;
58%
3-amino-4-bromo-1H-pyrazole
16461-94-2

3-amino-4-bromo-1H-pyrazole

2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

3-bromo-6-chloropyrazolo[1,5-a]pyrimidine
1314893-92-9

3-bromo-6-chloropyrazolo[1,5-a]pyrimidine

Conditions
ConditionsYield
With acetic acid In methanol at 70℃; for 2h;57%
2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

1-iodo-2,3-difluorobenzene
64248-57-3

1-iodo-2,3-difluorobenzene

4-chloro-1-(2,3-difluorophenyl)-1H-pyrazole
1152719-78-2

4-chloro-1-(2,3-difluorophenyl)-1H-pyrazole

Conditions
ConditionsYield
Stage #1: 1-iodo-2,3-difluorobenzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h;
Stage #2: With di-tert-butyl-diazodicarboxylate In tetrahydrofuran; hexane at -78 - 23℃; for 0.5h;
Stage #3: 2-chloromalonaldehyde With hydrogenchloride In tetrahydrofuran; 1,4-dioxane; hexane at 80℃; for 0.166667h;
55%
2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

2-iodochlorobenzene
615-41-8

2-iodochlorobenzene

4-chloro-1-(2-chlorophenyl)-1H-pyrazole
1152719-77-1

4-chloro-1-(2-chlorophenyl)-1H-pyrazole

Conditions
ConditionsYield
Stage #1: 2-iodochlorobenzene With n-butyllithium; di-tert-butyl-diazodicarboxylate In tetrahydrofuran; hexane at -78℃; for 0.133333h; Inert atmosphere;
Stage #2: 2-chloromalonaldehyde With hydrogenchloride In tetrahydrofuran; 1,4-dioxane; hexane at -78 - 80℃;
54%
2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

4-Bromophenylboronic acid
5467-74-3

4-Bromophenylboronic acid

1-(4-bromophenyl)-4-chloro-1H-pyrazole
1248589-16-3

1-(4-bromophenyl)-4-chloro-1H-pyrazole

Conditions
ConditionsYield
Stage #1: 4-Bromophenylboronic acid With di-tert-butyl-diazodicarboxylate; copper(II) acetate monohydrate In methanol at 65℃; for 1h;
Stage #2: 2-chloromalonaldehyde With hydrogenchloride In 1,4-dioxane; methanol at 20 - 80℃;
53%
2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

4-bromo-1-(4-fluorophenyl)-1H-pyrazole
957062-56-5

4-bromo-1-(4-fluorophenyl)-1H-pyrazole

4-(4-chloro-1H-pyrazol-1-yl)-1-(4-fluorophenyl)-1H-pyrazole
1152719-88-4

4-(4-chloro-1H-pyrazol-1-yl)-1-(4-fluorophenyl)-1H-pyrazole

Conditions
ConditionsYield
Stage #1: 4-bromo-1-(4-fluorophenyl)-1H-pyrazole With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h;
Stage #2: With di-tert-butyl-diazodicarboxylate In tetrahydrofuran; hexane at -78 - 23℃; for 0.5h;
Stage #3: 2-chloromalonaldehyde With hydrogenchloride In tetrahydrofuran; 1,4-dioxane; hexane at 80℃; for 0.166667h;
50%
2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

3-amino-2,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester
398491-59-3

3-amino-2,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester

6-chloro-1H,3H-2,4,7a,8-tetraaza-cyclopenta[a]indene-2-carboxylic acid tert-butyl ester
1444116-15-7

6-chloro-1H,3H-2,4,7a,8-tetraaza-cyclopenta[a]indene-2-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With acetic acid at 20℃; for 18h;47%
With acetic acid at 20℃; for 18h;47%
With acetic acid at 20℃; for 18h;47%
With acetic acid at 20℃; for 18h;47%
2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

C28H43F2N3O7
1152719-90-8

C28H43F2N3O7

(2R,6R)-4-(4-(4-chloro-1H-pyrazol-1-yl)-6-(5,5-dimethyl-1,3-dioxan-2-yl)-2,3-difluorophenyl)-2,6-dimethylmorpholine
1152719-72-6

(2R,6R)-4-(4-(4-chloro-1H-pyrazol-1-yl)-6-(5,5-dimethyl-1,3-dioxan-2-yl)-2,3-difluorophenyl)-2,6-dimethylmorpholine

Conditions
ConditionsYield
With hydrogenchloride In 1,4-dioxane Heating;45%
2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

(4-methyl-3-nitrophenyl)boronic acid
80500-27-2

(4-methyl-3-nitrophenyl)boronic acid

4-chloro-1-(4-methyl-3-nitrophenyl)-1H-pyrazole
1248589-25-4

4-chloro-1-(4-methyl-3-nitrophenyl)-1H-pyrazole

Conditions
ConditionsYield
Stage #1: (4-methyl-3-nitrophenyl)boronic acid With di-tert-butyl-diazodicarboxylate; copper(II) acetate monohydrate In methanol at 65℃; for 1h;
Stage #2: 2-chloromalonaldehyde With hydrogenchloride In 1,4-dioxane; methanol at 20 - 80℃;
45%
2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

2,4,6-trimethylphenyl bromide
576-83-0

2,4,6-trimethylphenyl bromide

4-chloro-1-mesityl-1H-pyrazole
1152719-81-7

4-chloro-1-mesityl-1H-pyrazole

Conditions
ConditionsYield
Stage #1: 2,4,6-trimethylphenyl bromide With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h;
Stage #2: With di-tert-butyl-diazodicarboxylate In tetrahydrofuran; hexane at -78 - 23℃; for 0.5h;
Stage #3: 2-chloromalonaldehyde With hydrogenchloride In tetrahydrofuran; 1,4-dioxane; hexane at 80℃; for 0.166667h;
43%
2-chloromalonaldehyde
36437-19-1

2-chloromalonaldehyde

5-amino-1H-pyrazole-4-carboxylic acid
41680-34-6

5-amino-1H-pyrazole-4-carboxylic acid

6-chloropyrazolo[1,5-a]pyrimidine-3-carboxylic acid
1204926-24-8

6-chloropyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Conditions
ConditionsYield
With acetic acid In ethanol at 80℃; for 1h; Inert atmosphere;40%
With acetic acid In ethanol at 60℃; for 2h;

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