2-Chloromalonaldehyde supplier

Name
2-Chloromalonaldehyde
EINECS
CAS No. 36437-19-1
Density 1.371 g/cm³
Solubility
Melting Point 140-145 °C
Formula C₃H₃ClO₂
Boiling Point 204.6 °C at 760 mmHg
Molecular Weight 106.509
Flash Point 77.5 °C
Transport Information
Appearance
Safety 36/37/39-26
Risk Codes 36/37/38-20/21/22
Molecular Structure
Hazard Symbols Xn
Synonyms Malonaldehyde,chloro- (6CI);Propanedial, chloro- (9CI);2-Chloro-1,3-propanedial;Chloromalonaldehyde;Chloromalonic dialdehyde;
PSA 34.14000
LogP -0.00840

Synthetic route

: 122-31-6
malondialdehyde bis(diethyl acetal)

: 36437-19-1
2-chloromalonaldehyde

Conditions

Conditions	Yield
With phosphorus pentachloride anschliessend Behandeln mit Sulfurylchlorid unter Zusatz von Dibenzoylperoxid und Schuetteln mit wss.Natriumcarbonat-Loesung;

: 20589-85-9
1,2,3,3-tetrachloro-1-propene

: 36437-19-1
2-chloromalonaldehyde

Conditions

Conditions	Yield
With sulfuric acid
With sulfuric acid at 30 - 40℃;

: 65041-41-0
5-tert-butoxy-6-chloro-2,3-dihydro-5H-[1,4]dioxepine

: 36437-19-1
2-chloromalonaldehyde

Conditions

Conditions	Yield
With hydrogenchloride In 1,4-dioxane Ambient temperature;

: 53923-47-0
7,7-dichloro-2,5-dioxybicyclo <4.1.0> heptane

: 36437-19-1
2-chloromalonaldehyde

Conditions

Conditions	Yield
With acetic acid Heating;

: 20589-85-9
1,2,3,3-tetrachloro-1-propene

: 7664-93-9
sulfuric acid

: 36437-19-1
2-chloromalonaldehyde

Conditions

Conditions	Yield
at 30 - 40℃;

trimethylene glycol diacetate: trimethylene glycol diacetate

: 36437-19-1
2-chloromalonaldehyde

Conditions

Conditions	Yield
With chlorine Irradiation.durch UV bei Raumtemperatur und 4-stdg. Erwaermen des Chlorierungsprodukts mit Aethanol oder laengeres Behandeln mit konz. H2SO4, zuletzt bei 40grad;

: 131139-84-9
3-anilino-2-chloro-acrylaldehyde

acid: acid

A: 36437-19-1
2-chloromalonaldehyde

B: 62-53-3
aniline

...Expand

: 131139-84-9
3-anilino-2-chloro-acrylaldehyde

alkali: alkali

A: 36437-19-1
2-chloromalonaldehyde

B: 62-53-3
aniline

...Expand

: 3-benzoyloxy-2-chloro-acrylaldehyde

alcoholic potash: alcoholic potash

A: 36437-19-1
2-chloromalonaldehyde

B: 65-85-0
benzoic acid

...Expand

: 951330-88-4
C10H15NO2S

: 36437-19-1
2-chloromalonaldehyde

: C13H15NO3S

Conditions

Conditions	Yield
With sodium hydrogencarbonate In tetrahydrofuran at 50℃; for 14h;	94%

: 36437-19-1
2-chloromalonaldehyde

: 3-amino-2-chloroacrolein

Conditions

Conditions	Yield
With ammonium hydroxide	93%

: 36437-19-1
2-chloromalonaldehyde

: 2521-24-6
4-chlorothiobenzamide

: 721920-84-9
2-(4-chloro-phenyl)-thiazole-5-carbaldehyde

Conditions

Conditions	Yield
With basic magnesium carbonate In water at 60℃; for 3h;	92%
With magnesium carbonate hexahydrate In 1,2-dimethoxyethane at 60℃; for 3h; Inert atmosphere;

: 27277-03-8
(3-amino-1H-1,2,4-triazol-5-yl)methanol

: 36437-19-1
2-chloromalonaldehyde

: 749929-28-0
(6-chloro-[1,2,4]triazolo[1,5-a]pyrimidine-2-yl)methanol

Conditions

Conditions	Yield
In acetic acid at 80℃; for 4h;	92%

: 36437-19-1
2-chloromalonaldehyde

: 5-(2-fluoro-5-nitrophenyl)-4H-1,2,4-triazol-3-amine

: C11H5ClFN5O2

Conditions

Conditions	Yield
With acetic acid at 120℃; for 3h;	87.7%

: 36437-19-1
2-chloromalonaldehyde

: Chloromalondialdehyd-kaliumsalz

Conditions

Conditions	Yield
With potassium hydroxide In water ice-cooled, pH 9;	85%

: 36437-19-1
2-chloromalonaldehyde

: 304853-90-5
(1,4-dihydro-4,4-dimethyl-2-oxo-2H-3,1-benzoxazin-6-yl)boronic acid

: 1248589-27-6
6-(4-chloro-1H-pyrazol-1-yl)-4,4-dimethyl-1H-benzo[d][1,3]oxazin-2(4H)-one

Conditions

Conditions	Yield
Stage #1: (1,4-dihydro-4,4-dimethyl-2-oxo-2H-3,1-benzoxazin-6-yl)boronic acid With di-tert-butyl-diazodicarboxylate; copper(II) acetate monohydrate In methanol at 65℃; for 1h; Stage #2: 2-chloromalonaldehyde With hydrogenchloride In 1,4-dioxane; methanol at 20 - 80℃;	78%

: 36437-19-1
2-chloromalonaldehyde

: 344-04-7
bromopentafluorobenzene

: 1152719-80-6
4-chloro-1-(perfluorophenyl)-1H-pyrazole

Conditions

Conditions	Yield
Stage #1: bromopentafluorobenzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h; Stage #2: With di-tert-butyl-diazodicarboxylate In tetrahydrofuran; hexane at -78 - 23℃; for 0.5h; Stage #3: 2-chloromalonaldehyde With hydrogenchloride In tetrahydrofuran; 1,4-dioxane; hexane at 80℃; for 0.166667h;	75%

: 36437-19-1
2-chloromalonaldehyde

: 402-43-7
p-trifluoromethylphenyl bromide

: 1152719-79-3
4-chloro-1-(4-(trifluoromethyl)phenyl)-1H-pyrazole

Conditions

Conditions	Yield
Stage #1: p-trifluoromethylphenyl bromide With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h; Stage #2: With di-tert-butyl-diazodicarboxylate In tetrahydrofuran; hexane at -78 - 23℃; for 0.5h; Stage #3: 2-chloromalonaldehyde With hydrogenchloride In tetrahydrofuran; 1,4-dioxane; hexane at 80℃; for 0.166667h;	75%

: 36437-19-1
2-chloromalonaldehyde

: 95-46-5
2-methylphenyl bromide

: 1152719-75-9
4-chloro-1-(o-tolyl)-1H-pyrazole

Conditions

Conditions	Yield
Stage #1: 2-methylphenyl bromide With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h; Stage #2: With di-tert-butyl-diazodicarboxylate In tetrahydrofuran; hexane at -78 - 23℃; for 0.5h; Stage #3: 2-chloromalonaldehyde With hydrogenchloride In tetrahydrofuran; 1,4-dioxane; hexane at 80℃; for 0.166667h;	73%

: 53939-30-3
5-bromo-2-chloropyridine

: 36437-19-1
2-chloromalonaldehyde

: 1152719-84-0
2-chloro-5-(4-chloro-1H-pyrazol-1-yl)pyridine

Conditions

Conditions	Yield
Stage #1: 5-bromo-2-chloropyridine With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h; Stage #2: With di-tert-butyl-diazodicarboxylate In tetrahydrofuran; hexane at -78 - 23℃; for 0.5h; Stage #3: 2-chloromalonaldehyde With hydrogenchloride In tetrahydrofuran; 1,4-dioxane; hexane at 80℃; for 0.166667h;	67%

: 36437-19-1
2-chloromalonaldehyde

: 77084-28-7
Dichloromalondialdehyd

Conditions

Conditions	Yield
With chlorine In dichloromethane at 5℃; 1.) 5 deg C, 2.) r.t., 1 h;	64%

: 5315-25-3
2-bromo-6-methylpyridine

: 36437-19-1
2-chloromalonaldehyde

: 1152719-82-8
2-(4-chloro-1H-pyrazol-1-yl)-6-methylpyridine

Conditions

Conditions	Yield
Stage #1: 2-bromo-6-methylpyridine With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h; Stage #2: With di-tert-butyl-diazodicarboxylate In tetrahydrofuran; hexane at -78 - 23℃; for 0.5h; Stage #3: 2-chloromalonaldehyde With hydrogenchloride In tetrahydrofuran; 1,4-dioxane; hexane at 80℃; for 0.166667h;	64%

: 36437-19-1
2-chloromalonaldehyde

: 352-34-1
4-fluoro-1-iodobenzene

: 1152719-73-7
4-chloro-1-(4-fluorophenyl)-1H-pyrazole

Conditions

Conditions	Yield
Stage #1: 4-fluoro-1-iodobenzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h; Stage #2: With di-tert-butyl-diazodicarboxylate In tetrahydrofuran; hexane at -78 - 23℃; for 0.5h; Stage #3: 2-chloromalonaldehyde With hydrogenchloride In tetrahydrofuran; 1,4-dioxane; hexane at 80℃; for 0.166667h;	64%

: 36437-19-1
2-chloromalonaldehyde

: 141041-86-3, 96929-01-0, 140903-30-6
tert-butyl (S)-(1-amino-1-thioxopropan-2-yl)carbamate

: 1332873-08-1
tert-butyl 1-(5-formylthiazol-2-yl)ethylcarbamate

Conditions

Conditions	Yield
With magnesium carbonate In 1,4-dioxane at 60℃; for 3h;	64%

: 36437-19-1
2-chloromalonaldehyde

: 1152719-91-9
C12H13BrF2O2

: 1152719-86-2
1-(3-bromo-5-(5,5-dimethyl-1,3-dioxan-2-yl)-2,6-difluorophenyl)-4-chloro-1H-pyrazole

Conditions

Conditions	Yield
Stage #1: C12H13BrF2O2 With lithium hexamethyldisilazane In tetrahydrofuran at -78℃; for 0.5h; Stage #2: With di-tert-butyl-diazodicarboxylate In tetrahydrofuran at -78 - 23℃; for 0.5h; Stage #3: 2-chloromalonaldehyde With hydrogenchloride In tetrahydrofuran; 1,4-dioxane; hexane at 100℃; for 0.0833333h;	61%

: 36437-19-1
2-chloromalonaldehyde

: 1152719-89-5
C18H24BrF2NO3

: 1152719-72-6
(2R,6R)-4-(4-(4-chloro-1H-pyrazol-1-yl)-6-(5,5-dimethyl-1,3-dioxan-2-yl)-2,3-difluorophenyl)-2,6-dimethylmorpholine

Conditions

Conditions	Yield
Stage #1: C18H24BrF2NO3 With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h; Stage #2: With di-tert-butyl-diazodicarboxylate In tetrahydrofuran; hexane at -78 - 20℃; for 0.583333h; Stage #3: 2-chloromalonaldehyde With hydrogenchloride In tetrahydrofuran; hexane; water at 100℃; for 0.0833333h;	60%

: 2398-37-0
3-methoxyphenyl bromide

: 36437-19-1
2-chloromalonaldehyde

: 1152719-76-0
4-chloro-1-(3-methoxyphenyl)-1H-pyrazole

Conditions

Conditions	Yield
Stage #1: 3-methoxyphenyl bromide With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h; Stage #2: With di-tert-butyl-diazodicarboxylate In tetrahydrofuran; hexane at -78 - 23℃; for 0.5h; Stage #3: 2-chloromalonaldehyde With hydrogenchloride In tetrahydrofuran; 1,4-dioxane; hexane at 80℃; for 0.166667h;	60%

: 766-11-0
5-bromo-2-fluoropyridine

: 36437-19-1
2-chloromalonaldehyde

: 1152719-83-9
5-(4-chloro-1H-pyrazol-1-yl)-2-fluoropyridine

Conditions

Conditions	Yield
Stage #1: 5-bromo-2-fluoropyridine With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h; Stage #2: With di-tert-butyl-diazodicarboxylate In tetrahydrofuran; hexane at -78 - 23℃; for 0.5h; Stage #3: 2-chloromalonaldehyde With hydrogenchloride In tetrahydrofuran; 1,4-dioxane; hexane at 80℃; for 0.166667h;	58%

: 16461-94-2
3-amino-4-bromo-1H-pyrazole

: 36437-19-1
2-chloromalonaldehyde

: 1314893-92-9
3-bromo-6-chloropyrazolo[1,5-a]pyrimidine

Conditions

Conditions	Yield
With acetic acid In methanol at 70℃; for 2h;	57%

: 36437-19-1
2-chloromalonaldehyde

: 64248-57-3
1-iodo-2,3-difluorobenzene

: 1152719-78-2
4-chloro-1-(2,3-difluorophenyl)-1H-pyrazole

Conditions

Conditions	Yield
Stage #1: 1-iodo-2,3-difluorobenzene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h; Stage #2: With di-tert-butyl-diazodicarboxylate In tetrahydrofuran; hexane at -78 - 23℃; for 0.5h; Stage #3: 2-chloromalonaldehyde With hydrogenchloride In tetrahydrofuran; 1,4-dioxane; hexane at 80℃; for 0.166667h;	55%

: 36437-19-1
2-chloromalonaldehyde

: 615-41-8
2-iodochlorobenzene

: 1152719-77-1
4-chloro-1-(2-chlorophenyl)-1H-pyrazole

Conditions

Conditions	Yield
Stage #1: 2-iodochlorobenzene With n-butyllithium; di-tert-butyl-diazodicarboxylate In tetrahydrofuran; hexane at -78℃; for 0.133333h; Inert atmosphere; Stage #2: 2-chloromalonaldehyde With hydrogenchloride In tetrahydrofuran; 1,4-dioxane; hexane at -78 - 80℃;	54%

: 36437-19-1
2-chloromalonaldehyde

: 5467-74-3
4-Bromophenylboronic acid

: 1248589-16-3
1-(4-bromophenyl)-4-chloro-1H-pyrazole

Conditions

Conditions	Yield
Stage #1: 4-Bromophenylboronic acid With di-tert-butyl-diazodicarboxylate; copper(II) acetate monohydrate In methanol at 65℃; for 1h; Stage #2: 2-chloromalonaldehyde With hydrogenchloride In 1,4-dioxane; methanol at 20 - 80℃;	53%

: 36437-19-1
2-chloromalonaldehyde

: 957062-56-5
4-bromo-1-(4-fluorophenyl)-1H-pyrazole

: 1152719-88-4
4-(4-chloro-1H-pyrazol-1-yl)-1-(4-fluorophenyl)-1H-pyrazole

Conditions

Conditions	Yield
Stage #1: 4-bromo-1-(4-fluorophenyl)-1H-pyrazole With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h; Stage #2: With di-tert-butyl-diazodicarboxylate In tetrahydrofuran; hexane at -78 - 23℃; for 0.5h; Stage #3: 2-chloromalonaldehyde With hydrogenchloride In tetrahydrofuran; 1,4-dioxane; hexane at 80℃; for 0.166667h;	50%

: 36437-19-1
2-chloromalonaldehyde

: 398491-59-3
3-amino-2,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester

: 1444116-15-7
6-chloro-1H,3H-2,4,7a,8-tetraaza-cyclopenta[a]indene-2-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
With acetic acid at 20℃; for 18h;	47%
With acetic acid at 20℃; for 18h;	47%
With acetic acid at 20℃; for 18h;	47%
With acetic acid at 20℃; for 18h;	47%

: 36437-19-1
2-chloromalonaldehyde

: 1152719-90-8
C28H43F2N3O7

: 1152719-72-6
(2R,6R)-4-(4-(4-chloro-1H-pyrazol-1-yl)-6-(5,5-dimethyl-1,3-dioxan-2-yl)-2,3-difluorophenyl)-2,6-dimethylmorpholine

Conditions

Conditions	Yield
With hydrogenchloride In 1,4-dioxane Heating;	45%

: 36437-19-1
2-chloromalonaldehyde

: 80500-27-2
(4-methyl-3-nitrophenyl)boronic acid

: 1248589-25-4
4-chloro-1-(4-methyl-3-nitrophenyl)-1H-pyrazole

Conditions

Conditions	Yield
Stage #1: (4-methyl-3-nitrophenyl)boronic acid With di-tert-butyl-diazodicarboxylate; copper(II) acetate monohydrate In methanol at 65℃; for 1h; Stage #2: 2-chloromalonaldehyde With hydrogenchloride In 1,4-dioxane; methanol at 20 - 80℃;	45%

: 36437-19-1
2-chloromalonaldehyde

: 576-83-0
2,4,6-trimethylphenyl bromide

: 1152719-81-7
4-chloro-1-mesityl-1H-pyrazole

Conditions

Conditions	Yield
Stage #1: 2,4,6-trimethylphenyl bromide With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h; Stage #2: With di-tert-butyl-diazodicarboxylate In tetrahydrofuran; hexane at -78 - 23℃; for 0.5h; Stage #3: 2-chloromalonaldehyde With hydrogenchloride In tetrahydrofuran; 1,4-dioxane; hexane at 80℃; for 0.166667h;	43%

: 36437-19-1
2-chloromalonaldehyde

: 41680-34-6
5-amino-1H-pyrazole-4-carboxylic acid

: 1204926-24-8
6-chloropyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Conditions

Conditions	Yield
With acetic acid In ethanol at 80℃; for 1h; Inert atmosphere;	40%
With acetic acid In ethanol at 60℃; for 2h;

2-Chloromalonaldehyde Specification

The CAS registry number of Propanedial, 2-chloro- is 36437-19-1. In addition, the molecular formula is C₃H₃ClO₂ and the molecular weight is 106.50. The IUPAC name is 2-chloropropanedial. What's more, it should be stored in sealed container, and put in a cool and dry place.

Physical properties about this chemical are: (1)ACD/LogP: -0.16; (2)ACD/LogD (pH 5.5): -2.24; (3)ACD/LogD (pH 7.4): -3.54; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 2; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 2; (11)Polar Surface Area: 26.3 Å²; (12)Index of Refraction: 1.488; (13)Molar Refractivity: 22.41 cm³; (14)Molar Volume: 77.6 cm³; (15)Polarizability: 8.88 ×10^-24cm³; (16)Surface Tension: 43 dyne/cm; (17)Density: 1.371 g/cm³; (18)Flash Point: 77.5 °C; (19)Enthalpy of Vaporization: 51.29 kJ/mol; (20)Boiling Point: 204.6 °C at 760 mmHg; (21)Vapour Pressure: 0.0625 mmHg at 25°C.

Uses of Propanedial, 2-chloro-: it can be used to get Chlormalonaldehyd. This reaction will need reagent KOH and solvent H₂O. The pH value of the reaction solution is 9. The yield is about 85%.

Propanedial, 2-chloro- can be used to get Chlormalonaldehyd.

When you are using this chemical, please be cautious about it as the following:
This chemical is harmful by inhalation, in contact with skin and if swallowed. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing, gloves and eye/face protection.

You can still convert the following datas into molecular structure:
(1)SMILES: O=CC(Cl)=CO
(2)Std. InChI: InChI=1S/C3H3ClO2/c4-3(1-5)2-6/h1-2,5H
(3)Std. InChIKey: SYXFXUMRQSTIKC-UHFFFAOYSA-N

Product Name

2-Chloromalonaldehyde

Synthetic route

2-Chloromalonaldehyde Specification

Related Products

Hot Products