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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

2-Bromo-5-chloropyridine Manufacturer/High quality/Best price/In stock

Cas:40473-01-6

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Jinan Finer Chemical Co., Ltd

Product Description Product website: http://www.finerchem.com Product Name 2-Bromo-5-chloropyridine CAS No. 40473-01-6 Appearance

2-Bromo-5-chloropyridine

Cas:40473-01-6

Min.Order:1 Gram

FOB Price: $8.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

High quality 2-Bromo-5-chloropyridine CAS 40473-01-6 with factory price Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Fe

High quality 2-Bromo-5-chloropyridine CAS 40473-01-6 with factory price

Cas:40473-01-6

Min.Order:10 Kilogram

FOB Price: $10.0

Type:Trading Company

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Hebei yanxi chemical co.,LTD.

Hebei Yanxi Chemical Co., Ltd. is a professional research, development and production of lead acetate benzene acetamide enterprise backbone members by local well-known entrepreneurs and professional senior engineers in the party's "low car

2-bromo-5-chloropyridine

Cas:40473-01-6

Min.Order:1 Metric Ton

FOB Price: $1.0 / 2.0

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea Port:shanghai

2-Bromo-5-chloropyridine

Cas:40473-01-6

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

2-Bromo-5-chloropyridine

Cas:40473-01-6

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

High quality and lower price of 2-Bromo-5-chloropyridine from HENAN TIANFU CHEMICAL: Henan Tianfu Chemical Co.,LTD was built in 2009 with an ISO certificate in the past 5 years, we have grown up as a famous fine chemicals supplier in china and we

2-Bromo-5-chloropyridine

Cas:40473-01-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

China Gold SupplierCAS 40473-01-6 with fast shipping

Cas:40473-01-6

Min.Order:10 Gram

FOB Price: $146.0 / 176.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Name: 2-Bromo-5-Chloropyridine Molecular Formula:C5H3BClN Molecular Weight:192.44 CAS No.:40473-01-6 Appearance:Similar White To Slight Yellow Solid Appearance:Similar White To Slight Yellow Solid Storage:Store in cool and dry place, away from su

2-Bromo-5-Chloropyridine CAS:40473-01-6

Cas:40473-01-6

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

2-Bromo-5-chloropyridine 40473-01-6

Cas:40473-01-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Pharmaceutical Intermediate, 2-Bromo-5-chloropyridine CAS:40473-01-6

Cas:40473-01-6

Min.Order:1 Gram

FOB Price: $7.2 / 8.4

Type:Trading Company

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Qingdao Beluga Import and Export Co., LTD

2-Bromo-5-chloropyridine CAS:40473-01-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic

2-Bromo-5-chloropyridine CAS:40473-01-6

Cas:40473-01-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

2-Bromo-5-chloropyridine

Cas:40473-01-6

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:40473-01-6

Cas:40473-01-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Factory Supply High Quality CAS 40473-01-6 ,2-Bromo-5-chloropyridine

Cas:40473-01-6

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

2-Bromo-5-Chloro-Pyridine

Cas:40473-01-6

Min.Order:0

Negotiable

Type:Manufacturers

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Triumph International Development Limilted

Appearance:white or light yellow crystalline powder Storage:Store in a cool,dry place and keep away from direct strong light Package:As customer request Application:Used for research and industrial manufacture. Transportation:By Se

2-Bromo-5-chloropyridine

Cas:40473-01-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

2-Bromo-5-chloropyridine

Cas:40473-01-6

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

2-Bromo-5-chloropyridine

Cas:40473-01-6

Min.Order:0

Negotiable

Type:Lab/Research institutions

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SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

2-Beromo-5-chloropyridine

Cas:40473-01-6

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 2-Bromo-5-chloro-pyridine

Cas:40473-01-6

Min.Order:0 Metric Ton

Negotiable

Type:Other

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Shaanxi Cuicheng Biomedical Technology Co., Ltd.

Why Choose Us: 1. Factory direct sales, so we can provide the competitive price and high quality product base on 8 years of production and R&D experience. 2. It is available in stock for quick shipment.Products could be packaged according to cu

2-Bromo-5-chloropyridine

Cas:40473-01-6

Min.Order:1 Gram

Negotiable

Type:Other

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Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 2-Bromo-5-chloropyridine

Cas:40473-01-6

Min.Order:100 Gram

Negotiable

Type:Other

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

2-bromo-5-chloropyridine CAS NO.40473-01-6

Cas:40473-01-6

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

2-Bromo-5-chloropyridine

Cas:40473-01-6

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

2-Bromo-5-chloropyridine Chemical Properties Melting point 65-69 °C Boiling point 128 °C / 16mmHg density 1.736±0.06 g/cm3(Predicted) form Powder pka -1.49±0.10(Predicted) color Beige to yellow-brown Water

2-Beromo-5-chloropyridine

Cas:40473-01-6

Min.Order:500 Kilogram

FOB Price: $66.0

Type:Lab/Research institutions

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

2-Bromo-5-chloropyridine

Cas:40473-01-6

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

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Changzhou Anchor Biological Technology Co., Ltd.

Our company is engaged in customizing the benzene ring and pyridine derivative organic intermediates, and the quantity is flexible according to customer's needs. It mainly provides high-quality intermediates for domestic and foreign pharmaceuti

2-Bromo-5-chloropyridine CAS:40473-01-6

Cas:40473-01-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

2-Bromo-5-chloropyridine

Cas:40473-01-6

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

2-Bromo-5-chloropyridine

Cas:40473-01-6

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

5-chloro-2-pyridylamine
1072-98-6

5-chloro-2-pyridylamine

2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

Conditions
ConditionsYield
With hydrogen bromide; bromine; sodium nitrite In water at 0 - 10℃; for 1.5h;93%
Stage #1: 5-chloro-2-pyridylamine With hydrogen bromide; bromine; sodium nitrite In water at 0℃; for 1h;
Stage #2: With sodium hydroxide In water; ethyl acetate
91%
With hydrogen bromide; bromine; sodium nitrite In water at 0℃; for 1h;91%
5-chloro-2-pyridylamine
1072-98-6

5-chloro-2-pyridylamine

A

2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

B

2-bromo-1,3-benzothiazole
2516-40-7

2-bromo-1,3-benzothiazole

Conditions
ConditionsYield
A 70%
B n/a
2,5 dichloropyridine
16110-09-1

2,5 dichloropyridine

2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

Conditions
ConditionsYield
With trimethylsilyl bromide In various solvent(s) Heating;67%
5-chloro-2-pyridinol
4214-79-3

5-chloro-2-pyridinol

2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

Conditions
ConditionsYield
With phosphorus(V) oxybromide for 16h; Heating / reflux;
propanal (5-chloropyridin-2-yl)hydrazone

propanal (5-chloropyridin-2-yl)hydrazone

2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: polyphosphoric acid / 0.08 h / 160 - 180 °C
2: bromine; hydrogen bromide; sodium nitrite / water / 1.5 h / 0 - 10 °C
View Scheme
butanal (5-chloropyridin-2-yl)hydrazone

butanal (5-chloropyridin-2-yl)hydrazone

2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: polyphosphoric acid / 0.08 h / 160 - 180 °C
2: bromine; hydrogen bromide; sodium nitrite / water / 1.5 h / 0 - 10 °C
View Scheme
phenylethanal (5-chloropyridin-2-yl)hydrazone

phenylethanal (5-chloropyridin-2-yl)hydrazone

2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: polyphosphoric acid / 0.08 h / 160 - 180 °C
2: bromine; hydrogen bromide; sodium nitrite / water / 1.5 h / 0 - 10 °C
View Scheme
2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

triphenylbismuthane
603-33-8

triphenylbismuthane

5-chloro-2-phenylpyridine
58254-76-5

5-chloro-2-phenylpyridine

Conditions
ConditionsYield
With potassium acetate; palladium diacetate; triphenylphosphine In 1-methyl-pyrrolidin-2-one at 110℃; for 2h; Schlenk technique; Inert atmosphere; chemoselective reaction;98%
2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

3-(5-bromofuran-2-yl)-benzonitrile
453568-66-6

3-(5-bromofuran-2-yl)-benzonitrile

3-(5-(5-choro-2-pyridyl)-2-furyl)-benzonitrile
453568-67-7

3-(5-(5-choro-2-pyridyl)-2-furyl)-benzonitrile

Conditions
ConditionsYield
With hexamethyldistannane; Pd(PPh3)4 In hexane; dichloromethane; chloroform; ethyl acetate97.5%
2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

tris(4-chlorophenyl)bismuthane
5575-51-9

tris(4-chlorophenyl)bismuthane

5-chloro-2-(4-chlorophenyl)pyridine

5-chloro-2-(4-chlorophenyl)pyridine

Conditions
ConditionsYield
With potassium acetate; palladium diacetate; triphenylphosphine In 1-methyl-pyrrolidin-2-one at 110℃; for 2h; Schlenk technique; Inert atmosphere; chemoselective reaction;96%
2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

2-vinylbenzeneboronic acid
15016-42-9

2-vinylbenzeneboronic acid

5-chloro-2-(2-vinylphenyl)pyridine

5-chloro-2-(2-vinylphenyl)pyridine

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In ethanol; toluene at 100℃; for 8h; Inert atmosphere;96%
2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

tris-(4-ethoxy-phenyl)-bismuthine
90591-48-3

tris-(4-ethoxy-phenyl)-bismuthine

5-chloro-2-(4-ethoxyphenyl)pyridine

5-chloro-2-(4-ethoxyphenyl)pyridine

Conditions
ConditionsYield
With potassium acetate; palladium diacetate; triphenylphosphine In 1-methyl-pyrrolidin-2-one at 110℃; for 2h; Schlenk technique; Inert atmosphere; chemoselective reaction;95%
2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

phenylboronic acid
98-80-6

phenylboronic acid

5-chloro-2-phenylpyridine
58254-76-5

5-chloro-2-phenylpyridine

Conditions
ConditionsYield
With [Pd(N-(3-chloro-2-quinoxalinyl)-N'-(2,6-diisopropylphenyl)imidazolium)(PPh3)Cl2]; potassium carbonate In water at 70℃; for 3h; Catalytic behavior; Suzuki-Miyaura Coupling;94%
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In ethanol; water; toluene for 12h; Suzuki Coupling; Reflux; Inert atmosphere;
With potassium phosphate tribasic heptahydrate; palladium diacetate In water; isopropyl alcohol at 80℃;
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In ethanol; water; toluene for 2h; Schlenk technique; Inert atmosphere; Reflux;
2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

methanol
67-56-1

methanol

carbon monoxide
201230-82-2

carbon monoxide

methyl 5-chloropyridine-2-carboxylate
132308-19-1

methyl 5-chloropyridine-2-carboxylate

Conditions
ConditionsYield
With triethylamine; palladium diacetate; 1,1'-bis(diphenylphosphino)ferrocene at 50℃; under 775.743 Torr; for 24h;93%
With triethylamine; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate at 50℃; under 775.743 Torr; for 24h;93%
With triethylamine; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate at 50℃; under 775.743 Torr; for 24h;93%
2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

indole-2,3-dione
91-56-5

indole-2,3-dione

8-chloro-11H-pyrido[2,1-b]quinazoline-11-one

8-chloro-11H-pyrido[2,1-b]quinazoline-11-one

Conditions
ConditionsYield
With copper(II) acetate monohydrate; sodium hydrogencarbonate In N,N-dimethyl-formamide at 120℃; for 10h;91%
2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

5-methoxyisatine
39755-95-8

5-methoxyisatine

8-chloro-2-methoxy-11H-pyrido[2,1-b]quinazolin-11-one

8-chloro-2-methoxy-11H-pyrido[2,1-b]quinazolin-11-one

Conditions
ConditionsYield
With copper(II) acetate monohydrate; sodium hydrogencarbonate In N,N-dimethyl-formamide at 120℃; for 10h;91%
2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

(R)-ethyl 3-(3-amino-5-fluoro-4-(isobutyl(tetrahydro-2H-pyran-4-yl)amino)phenyl)butanoate

(R)-ethyl 3-(3-amino-5-fluoro-4-(isobutyl(tetrahydro-2H-pyran-4-yl)amino)phenyl)butanoate

(R)-ethyl 3-(3-((5-chloropyridin-2-yl)amino)-5-fluoro-4-(isobutyl(tetrahydro-2H-pyran-4-yl)amino)phenyl)butanoate

(R)-ethyl 3-(3-((5-chloropyridin-2-yl)amino)-5-fluoro-4-(isobutyl(tetrahydro-2H-pyran-4-yl)amino)phenyl)butanoate

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 100℃; for 1h; Inert atmosphere;91%
2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

ethyl 4-formyl-1H-pyrazol-3(5)-carboxylate
179692-09-2

ethyl 4-formyl-1H-pyrazol-3(5)-carboxylate

ethyl 1-(5-chloropyridin-2-yl)-4-formyl-1H-pyrazole-3-carboxylate
1224172-54-6

ethyl 1-(5-chloropyridin-2-yl)-4-formyl-1H-pyrazole-3-carboxylate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 2h;90%
With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 2h;90%
2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

2-chloro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
652148-92-0

2-chloro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

5,6′-dichloro-2,2′-bipyridine

5,6′-dichloro-2,2′-bipyridine

Conditions
ConditionsYield
With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); triethylamine In tetrahydrofuran; water at 20℃; for 2h; Suzuki-Miyaura Coupling; Inert atmosphere; chemoselective reaction;90%
2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

4-Phenyl-1-butyne
16520-62-0

4-Phenyl-1-butyne

5-chloro-2-(4-phenylbut-1-yn-1-yl)pyridine
1428857-25-3

5-chloro-2-(4-phenylbut-1-yn-1-yl)pyridine

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 20℃; for 0.5h; Sonogashira Cross-Coupling;89%
1,4-diaza-bicyclo[2.2.2]octane
280-57-9

1,4-diaza-bicyclo[2.2.2]octane

2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

potassium phtalimide
1074-82-4

potassium phtalimide

2-(2-(4-(5-chloropyridin-2-yl)piperazin-1-yl)ethyl)isoindoline-1,3-dione

2-(2-(4-(5-chloropyridin-2-yl)piperazin-1-yl)ethyl)isoindoline-1,3-dione

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 120℃; for 24h;89%
In N,N-dimethyl-formamide at 120℃; for 24h; Inert atmosphere;88%
2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

methyl 2-(3-amino-4-(isobutyl(tetrahydro-2H-pyran-4-yl)amino)phenyl)-2-methylpropanoate

methyl 2-(3-amino-4-(isobutyl(tetrahydro-2H-pyran-4-yl)amino)phenyl)-2-methylpropanoate

methyl 2-(3-((5-chloropyridin-2-yl)amino)-4-(isobutyl(tetrahydro-2H-pyran-4-yl)amino)phenyl)-2-methylpropanoate

methyl 2-(3-((5-chloropyridin-2-yl)amino)-4-(isobutyl(tetrahydro-2H-pyran-4-yl)amino)phenyl)-2-methylpropanoate

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 100℃; Inert atmosphere;89%
2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

methyl [(2S)-3-methyl-1-oxo-1-{(2S)-2-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]pyrrolidin-1-yl}butan-2-yl]carbamate
1228552-50-8

methyl [(2S)-3-methyl-1-oxo-1-{(2S)-2-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]pyrrolidin-1-yl}butan-2-yl]carbamate

methyl (S)-1-((S)-2-(5-(5-chloropyridin-2-yl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate
1399843-62-9

methyl (S)-1-((S)-2-(5-(5-chloropyridin-2-yl)-1H-benzo[d]imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-ylcarbamate

Conditions
ConditionsYield
With caesium carbonate; tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane at 80℃; for 16h; Sealed tube; Inert atmosphere;88%
2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

5-chloro-2-iodo-pyridine
244221-57-6

5-chloro-2-iodo-pyridine

Conditions
ConditionsYield
With chloro-trimethyl-silane; sodium iodide In various solvent(s) for 6h; Heating;87%
Stage #1: 2-Bromo-5-chloro-pyridine With acetyl chloride; sodium iodide In acetonitrile for 3h; Heating / reflux;
Stage #2: With potassium carbonate In water; acetonitrile at 0℃;
75%
Stage #1: 2-Bromo-5-chloro-pyridine With acetyl chloride; sodium iodide In acetonitrile for 6h; Heating / reflux;
Stage #2: With potassium carbonate In water; acetonitrile at 0℃;
75%
With chloro-trimethyl-silane; sodium iodide In acetonitrile Reflux;
2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

tri(p-isopropoxyphenyl)bismuth
95149-18-1

tri(p-isopropoxyphenyl)bismuth

5-chloro-2-(4-isopropoxyphenyl)pyridine

5-chloro-2-(4-isopropoxyphenyl)pyridine

Conditions
ConditionsYield
With potassium acetate; palladium diacetate; triphenylphosphine In 1-methyl-pyrrolidin-2-one at 110℃; for 2h; Schlenk technique; Inert atmosphere; chemoselective reaction;87%
2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

tris(4-methoxyphenyl)bismuth
33397-21-6

tris(4-methoxyphenyl)bismuth

5-chloro-2-(4-methoxyphenyl)pyridine

5-chloro-2-(4-methoxyphenyl)pyridine

Conditions
ConditionsYield
With potassium acetate; palladium diacetate; triphenylphosphine In 1-methyl-pyrrolidin-2-one at 110℃; for 2h; Schlenk technique; Inert atmosphere; chemoselective reaction;86%
2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

triethylsilyl chloride
994-30-9

triethylsilyl chloride

2-bromo-5-chloro-4-(triethylsilyl)pyridine

2-bromo-5-chloro-4-(triethylsilyl)pyridine

Conditions
ConditionsYield
With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -20℃; for 1.25h;86%
2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

S-Methylisothiourea sulfate
867-44-7

S-Methylisothiourea sulfate

5-chloro-2-(methylsulfanyl)pyridine
89379-91-9

5-chloro-2-(methylsulfanyl)pyridine

Conditions
ConditionsYield
With caesium carbonate In dimethyl sulfoxide at 80℃; for 5h;86%
2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

N,N-dimethyl acetamide
127-19-5

N,N-dimethyl acetamide

1-(5-chloropyridin-2-yl)ethan-1-one
94952-46-2

1-(5-chloropyridin-2-yl)ethan-1-one

Conditions
ConditionsYield
Stage #1: 2-Bromo-5-chloro-pyridine With sec.-butyllithium In diethyl ether; hexane at -60℃; for 2h;
Stage #2: N,N-dimethyl acetamide In diethyl ether; hexane for 3h;
Stage #3: With hydrogenchloride; water In diethyl ether; hexane
85%
Stage #1: 2-Bromo-5-chloro-pyridine With n-butyllithium In diethyl ether; hexane at -78℃;
Stage #2: N,N-dimethyl acetamide In diethyl ether; hexane for 0.5h;
59%
With n-butyllithium In diethyl ether; hexane at -78℃; for 0.5h;59%
Stage #1: 2-Bromo-5-chloro-pyridine With sec.-butyllithium In cyclohexane at -74℃; for 1.66667h;
Stage #2: N,N-dimethyl acetamide In diethyl ether; cyclohexane at -74℃; for 1.66667h;
2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

2-Methylphenylboronic acid
16419-60-6

2-Methylphenylboronic acid

5-chloro-2-(o-tolyl)pyridine
1345043-96-0

5-chloro-2-(o-tolyl)pyridine

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In ethanol; water; toluene Reflux;84%
With Pd-catalyzed Suzuki coupling;
2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

N-boc-2-pyrroleboronic acid
135884-31-0

N-boc-2-pyrroleboronic acid

tert-butyl 2-(5-chloropyridin-2-yl)-1H-pyrrole-1-carboxylate

tert-butyl 2-(5-chloropyridin-2-yl)-1H-pyrrole-1-carboxylate

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In tetrahydrofuran; water Suzuki Coupling; Inert atmosphere; Reflux;84%
2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

5-(chloromethyl)-1,3-oxazolidin-2-one
22625-57-6

5-(chloromethyl)-1,3-oxazolidin-2-one

5-(chloromethyl)-3-(5-chloropyridin-2-yl)-1,3-oxazolidin-2-one
1093752-23-8

5-(chloromethyl)-3-(5-chloropyridin-2-yl)-1,3-oxazolidin-2-one

Conditions
ConditionsYield
With caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium(0) In 1,4-dioxane at 85℃; for 12h;83%
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 80℃;
2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

5-chloro-pyridin-2-yl hydrazine
27032-63-9

5-chloro-pyridin-2-yl hydrazine

Conditions
ConditionsYield
With hydrazine hydrate In isopropyl alcohol for 10h; Reflux;82%
2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

benzyl (4R)-2,2-dimethyl-4-vinyl-1,3-oxazolidine-3-carboxylate
271260-90-3

benzyl (4R)-2,2-dimethyl-4-vinyl-1,3-oxazolidine-3-carboxylate

(R)-2-(benzyloxycarbonyl)amino-4-(4-chloropyridin-2-yl)-1-butanol
271261-12-2

(R)-2-(benzyloxycarbonyl)amino-4-(4-chloropyridin-2-yl)-1-butanol

Conditions
ConditionsYield
Stage #1: benzyl (4R)-2,2-dimethyl-4-vinyl-1,3-oxazolidine-3-carboxylate With 9-borabicyclo[3.3.1]nonane dimer In toluene at 80 - 85℃; hydroboration;
Stage #2: 2-Bromo-5-chloro-pyridine With sodium hydroxide; tetrakis(triphenylphosphine) palladium(0); tetra-(n-butyl)ammonium iodide In toluene at 90℃; Suzuki cross-coupling;
Stage #3: With hydrogenchloride In methanol for 24h; Ring cleavage; Further stages.;
81%
2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

5-chloroindole 2,3-dione
17630-76-1

5-chloroindole 2,3-dione

2,8-dichloro-11H-pyrido[2,1-b]quinazolin-11-one

2,8-dichloro-11H-pyrido[2,1-b]quinazolin-11-one

Conditions
ConditionsYield
With copper(II) acetate monohydrate; sodium hydrogencarbonate In N,N-dimethyl-formamide at 120℃; for 10h;81%
2-Bromo-5-chloro-pyridine
40473-01-6

2-Bromo-5-chloro-pyridine

4-{3-[4-(difluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}pyrrolidin-2-one

4-{3-[4-(difluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}pyrrolidin-2-one

1-(5-chloropyridin-2-yl)-4-[3-{4-(difluoromethoxy)phenyl}-1,2,4-oxadiazol-5-yl]pyrrolidin-2-one

1-(5-chloropyridin-2-yl)-4-[3-{4-(difluoromethoxy)phenyl}-1,2,4-oxadiazol-5-yl]pyrrolidin-2-one

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene at 120℃; for 2h; Inert atmosphere;81%

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