Top Supplier of N-(4-Cyanophenyl)glycine CAS:42288-26-6 Appearance:off-white powder Storage:store in well closed container Package:25kgs/fiber drum Application:Dabigartan intermediate Transportation:by air or by sea Port:any port in China
Cas:42288-26-6
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inquiryItems Standard Result Assay (Ursolic acid) 98%min 98.22% ----------------------------------------------------------------
Cas:42288-26-6
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inquiryProduct Description Product website: http://www.finerchem.com/pro01en/id/229.html Product Name N-(4-Cyanophenyl)glycine CAS No. 42288-26-6
Cas:42288-26-6
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inquiryUnique advantages for N-(4-Cyano-phenyl)-glycine Cas 42288-26-6 Guaranteed the purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:cool dry place Package:10g,100g,1kg/foil bag
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inquiryPurity with 99% Competitive price with good quality Fast delivery Appearance:White powder Storage:Store in cool dry place Package:25kg/drum Application:Pharmaceutical Intermediates / Medicine Intermediates Port:Shanghai, Nanjing
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inquiryN-(4-Cyanophenyl)glycine CAS No.:42288-26-6 Name: N-(4-Cyanophenyl)glycine Synonyms: 2-(4-Cyanophenylamino)acetic acid Molecular Structure Molecular Formula: C9H8N2O2 Molecu
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inquiryThe above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi
Good quality Good price Promptly delivery Appearance:white powder Storage:dry dondition Application:intermediate Port:shanghai
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
Cas:42288-26-6
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
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inquiryDabigatran Intermediate CAS: 42288-26-6 High quality: testing result of assay 99%up . Single impurity below 0.1% . Total impurity 0.5% below High capacity: 500ton per year Appearance:White to off-white crystalline powder Package:25kg/drum Appl
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inquiryCompetitive Price High Quality Fast Delivery custom-made Welcome to Henan Tianfu Chemical Co., Ltd. website. Our company engages in Sodium Tripolyphosphate (STPP) and Sodium Hexametabphosphate (SHMP) production; development of noble me
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inquiryDensity: 1.30 ± 0.1 g/cm3 (Predicted) Melting point: 237 ° C (dec.) Boiling point: 447.2 ± 30.0 ° C (Predicted) Flash point: 224.3 ° C Steam pressure: 8.8E-09mmHg at 25 ° C Solubility: Dichroromethane (Slightly), DMSO (S
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inquiryProduct Name N-(4-Cyano-Phenyl)-Glycine Synonyms N-(4-CYANO-PHENYL)-GLYCINE;Dabigatran Intermediate 2;[(4-Cyanophenyl)aMino]acetic Acid;4-(((Carboxy)Methyl)aMino)benzonit
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Cas:42288-26-6
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inquiryN-(4-CYANO-PHENYL)-GLYCINE CAS:42288-26-6 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organi
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inquiryProduct Name: N-(4-CYANO-PHENYL)-GLYCINE Synonyms: N-(4-CYANO-PHENYL)-GLYCINE;Dabigatran Intermediate 2;[(4-Cyanophenyl)aMino]acetic Acid;4-(((Carboxy)Methyl)aMino)benzonitrile;N-(p-Cyanophenyl)glycine;Dabigatran pharMaceutical interMediate;N-(4-
Cas:42288-26-6
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inquiryBest quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia
Conditions | Yield |
---|---|
In water at 100 - 110℃; for 3h; | 88% |
In water at 100℃; for 16h; | |
In water at 20 - 100℃; for 16.4h; | |
In water at 100℃; for 5h; | |
In water at 100℃; |
Conditions | Yield |
---|---|
With potassium phosphate; copper(l) iodide; N-((1-oxy-pyridin-2-yl)methyl)oxalamic acid In water; dimethyl sulfoxide at 25℃; for 48h; Schlenk technique; Inert atmosphere; Sealed tube; chemoselective reaction; | 88% |
sodium monochloroacetic acid
4-Aminobenzonitrile
(4-cyanophenyl)glycine
Conditions | Yield |
---|---|
In water for 6.5h; Product distribution / selectivity; Reflux; | 73.2% |
With water at 0℃; Product distribution / selectivity; Reflux; | 73.2% |
Stage #1: sodium monochloroacetic acid; 4-Aminobenzonitrile With tetrabutylammomium bromide; sodium hydrogencarbonate; potassium iodide In water at 90 - 95℃; for 24h; Stage #2: With ammonia In water at 20 - 30℃; for 0.333333h; pH=7.5; Stage #3: With hydrogenchloride In water at 20 - 30℃; for 3h; pH=2.5; Product distribution / selectivity; | |
With tetrabutylammomium bromide; sodium hydrogencarbonate; potassium iodide In water at 90 - 95℃; for 24h; | 131 g |
With tetrabutylammomium bromide; sodium hydrogencarbonate; potassium iodide In water at 85 - 90℃; for 24h; | 120 g |
Conditions | Yield |
---|---|
In water Reflux; | 73% |
In water Heating / reflux; | 58% |
In water Reflux; | 47% |
With water |
Conditions | Yield |
---|---|
With sodium cyanoborohydride for 2h; Milling; | 56% |
(4-cyanophenylamino)-acetic acid tert-butyl ester
(4-cyanophenyl)glycine
Conditions | Yield |
---|---|
With methoxybenzene; trifluoroacetic acid | |
With trifluoroacetic acid In dichloromethane for 24h; Ambient temperature; |
4-Aminobenzonitrile
(4-cyanophenyl)glycine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: K2CO3 / dimethylformamide / 16 h / 80 °C 2: TFA / CH2Cl2; various solvent(s) / 24 h / Ambient temperature View Scheme | |
Multi-step reaction with 2 steps 1: K2CO3 2: TFA, anisole View Scheme |
(R)-2-(4-methylamino-3-amino-phenyl)-2-tert.butyloxycarbonylamino-1-pyrrolidino-propanone
(4-cyanophenyl)glycine
1,1'-carbonyldiimidazole
Conditions | Yield |
---|---|
In tetrahydrofuran; acetic acid | 100% |
(4-cyanophenyl)glycine
ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate
3-({3-[2-(4-cyano-phenylamino)-acetylamino]-4-methylamino-benzoyl}-pyridin-2-yl-amino)-ethyl propanoate
Conditions | Yield |
---|---|
Stage #1: (4-cyanophenyl)glycine With 1,1'-carbonyldiimidazole In dichloromethane at 0 - 5℃; for 6h; Large scale; Stage #2: ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate In dichloromethane at 20℃; for 24h; Solvent; Reagent/catalyst; Large scale; | 99.3% |
Stage #1: (4-cyanophenyl)glycine With 1,1'-carbonyldiimidazole In tetrahydrofuran at 20℃; for 0.5h; Stage #2: ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate In tetrahydrofuran at 20℃; | 93.8% |
Stage #1: (4-cyanophenyl)glycine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In tetrahydrofuran at 0 - 10℃; for 0.5h; Large scale; Stage #2: ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate In tetrahydrofuran at 20 - 25℃; for 6h; Large scale; | 84.33% |
Stage #1: (4-cyanophenyl)glycine With 1,1'-carbonyldiimidazole In tetrahydrofuran at 50℃; Stage #2: ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate In tetrahydrofuran for 24h; Heating; Further stages.; |
(4-cyanophenyl)glycine
(piperidin-4-yl)carbamic acid tert-butyl ester
Conditions | Yield |
---|---|
With 1-[(1-(cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino)]-uronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; | 99% |
(4-cyanophenyl)glycine
tert-butyl N-(4-piperidinylmethyl)carbamate
Conditions | Yield |
---|---|
With 1-[(1-(cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino)]-uronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; | 98% |
(4-cyanophenyl)glycine
3-({3-[2-(4-Cyano-phenylamino)-acetylamino]-4-methylamino-benzoyl}-phenyl-amino)-propionic acid methyl ester
Conditions | Yield |
---|---|
With 1,1'-carbonyldiimidazole In tetrahydrofuran | 97% |
4-[1-(pyrrolidin-1-yl-carbonyl)cyclopropyl]-2-nitro-N-methylaniline
(4-cyanophenyl)glycine
Conditions | Yield |
---|---|
With triethylamine In N-methyl-acetamide | 96% |
(4-cyanophenyl)glycine
ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate
3-[[[2-[[(4-cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino]propionic acid ethyl ester
Conditions | Yield |
---|---|
Stage #1: (4-cyanophenyl)glycine; ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate With 1,1'-carbonyldiimidazole In Isopropyl acetate at 20℃; for 4h; Stage #2: With acetic acid In Isopropyl acetate for 2h; Reflux; | 95% |
Stage #1: (4-cyanophenyl)glycine With 1,1'-carbonyldiimidazole In toluene at 50℃; Stage #2: ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate In toluene at 20 - 25℃; Temperature; | 93.97% |
Stage #1: (4-cyanophenyl)glycine With benzotriazol-1-ol; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 3℃; for 1h; Stage #2: ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate In N,N-dimethyl-formamide at 20℃; for 6h; Temperature; Further stages; | 91.1% |
(4-cyanophenyl)glycine
Conditions | Yield |
---|---|
Stage #1: (4-cyanophenyl)glycine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N,N-dimethyl-formamide In tetrahydrofuran for 0.5h; Cooling with ice; Stage #2: 3-[(3-amino-4-butyl aminobenzoyl)(3-chloro-4-fluorophenyl)amino]propionic acid ethyl ester In tetrahydrofuran at 20℃; for 4h; Stage #3: With acetic acid for 3h; Reflux; | 95% |
(4-cyanophenyl)glycine
Conditions | Yield |
---|---|
Stage #1: (4-cyanophenyl)glycine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran; N,N-dimethyl-formamide for 0.583333h; Cooling with ice; Stage #2: 3-[(3-amino-4-ethylamino-benzoyl)-(3,5-difluorophenyl)-amino]-propionic acid ethyl ester In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; Stage #3: With acetic acid at 120℃; for 2 - 3h; | 93% |
(4-cyanophenyl)glycine
acetic acid
ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate
1-methyl-2-[N-(4-cyanophenyl)aminomethyl]benzimidazole-5-ylcarboxylic acid N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide acetate salt
Conditions | Yield |
---|---|
Stage #1: (4-cyanophenyl)glycine With 1,1'-carbonyldiimidazole In tetrahydrofuran for 0.666667h; Inert atmosphere; Reflux; Stage #2: ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate In tetrahydrofuran for 5h; Inert atmosphere; Reflux; Stage #3: acetic acid In tetrahydrofuran for 1h; Reflux; | 92% |
(4-cyanophenyl)glycine
toluene-4-sulfonic acid
ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate
Conditions | Yield |
---|---|
Stage #1: (4-cyanophenyl)glycine With pivaloyl chloride; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0 - 5℃; Stage #2: ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate In tetrahydrofuran at 0 - 5℃; for 0.0833333h; Stage #3: toluene-4-sulfonic acid Further stages; | 89.59% |
Stage #1: (4-cyanophenyl)glycine With Imidazole hydrochloride; 1,1'-carbonyldiimidazole In dichloromethane at 35 - 40℃; for 1h; Inert atmosphere; Stage #2: ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate In dichloromethane for 1h; Inert atmosphere; Reflux; Stage #3: toluene-4-sulfonic acid In acetic acid butyl ester at 85 - 90℃; for 1h; Solvent; Inert atmosphere; | 15.8 g |
(4-cyanophenyl)glycine
Conditions | Yield |
---|---|
Stage #1: (4-cyanophenyl)glycine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran; N,N-dimethyl-formamide for 0.583333h; Cooling with ice; Stage #2: ethyl 3-(3-amino-4-(ethylamino)-N-(2-fluorophenyl)-benzamido)propanoate In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; Stage #3: With acetic acid at 120℃; for 2 - 3h; | 89% |
(4-cyanophenyl)glycine
Conditions | Yield |
---|---|
Stage #1: (4-cyanophenyl)glycine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran; N,N-dimethyl-formamide for 0.5h; Cooling with ice; Stage #2: 3-[(3-amino-4-methylaminobenzoyl)-(2-methoxyphenyl)amino]-propionic acid ethyl ester In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 5h; | 89% |
(4-cyanophenyl)glycine
Conditions | Yield |
---|---|
Stage #1: (4-cyanophenyl)glycine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran; N,N-dimethyl-formamide for 0.5h; Cooling with ice; Stage #2: ethyl 5-[3-amino-4-(ethylamino)phenyl]-4-(2,3-dimethylphenyl)-5-oxopentanoate In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; | 87.6% |
(4-cyanophenyl)glycine
Conditions | Yield |
---|---|
Stage #1: (4-cyanophenyl)glycine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran; N,N-dimethyl-formamide for 0.5h; Cooling with ice; Stage #2: 3-[(3-amino-4-ethylaminobenzoyl)-(2,3-dimethylphenyl)amino]propionic acid ethyl ester In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 10h; | 87.6% |
(4-cyanophenyl)glycine
Conditions | Yield |
---|---|
Stage #1: (4-cyanophenyl)glycine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran; N,N-dimethyl-formamide for 0.5h; Cooling with ice; Stage #2: 3-[(3-amino-4-ethylaminobenzoyl)-(4-fluoro-3-methylphenyl)amino]propionic acid ethyl ester In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 10h; | 87.6% |
tert-butyl N-[(4-fluoropiperidin-4-yl)methyl]carbamate
(4-cyanophenyl)glycine
Conditions | Yield |
---|---|
With 1-[(1-(cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino)]-uronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; | 87% |
(4-cyanophenyl)glycine
Conditions | Yield |
---|---|
Stage #1: (4-cyanophenyl)glycine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran; N,N-dimethyl-formamide for 0.5h; Cooling with ice; Stage #2: 3-[(3-amino-4-ethylamino-benzoyl)-(3,5-dimethylphenyl)-amino]-propionic acid ethyl ester In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 10h; | 86.1% |
(4-cyanophenyl)glycine
Conditions | Yield |
---|---|
Stage #1: (4-cyanophenyl)glycine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N,N-dimethyl-formamide In tetrahydrofuran for 0.5h; Cooling with ice; Stage #2: 3-[(3-chloro-4-methyl amino benzoyl)(3-chloro-4-fluorophenyl)amino]propionic acid ethyl ester In tetrahydrofuran at 20℃; for 4h; Stage #3: With acetic acid for 3h; Reflux; | 86% |
Conditions | Yield |
---|---|
With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide In dichloromethane at 10 - 20℃; | 86% |
(4-cyanophenyl)glycine
Conditions | Yield |
---|---|
Stage #1: (4-cyanophenyl)glycine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran; N,N-dimethyl-formamide for 0.5h; Cooling with ice; Stage #2: 3-[(3-amino-4-ethylaminobenzoyl)-(3-fluoro-4-methylphenyl)amino]propionic acid ethyl ester In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 10h; | 85.8% |
(4-cyanophenyl)glycine
Conditions | Yield |
---|---|
Stage #1: (4-cyanophenyl)glycine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran; N,N-dimethyl-formamide for 0.5h; Cooling with ice; Stage #2: ethyl 5-[3-amino-4-(ethylamino)phenyl]-4-(2,4-dimethylphenyl)-5-oxopentanoate In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; | 85.5% |
(4-cyanophenyl)glycine
Conditions | Yield |
---|---|
Stage #1: (4-cyanophenyl)glycine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran; N,N-dimethyl-formamide for 0.5h; Cooling with ice; Stage #2: 3-[(3-amino-4-ethylamino-benzoyl)-(3,4-dimethylphenyl)-amino]-propionic acid ethyl ester In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 10h; | 85.5% |
(4-cyanophenyl)glycine
Conditions | Yield |
---|---|
Stage #1: (4-cyanophenyl)glycine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran; N,N-dimethyl-formamide for 0.5h; Cooling with ice; Stage #2: 3-[(3-amino-4-ethylamino-benzoyl)-(2,4-dimethylphenyl)-amino]-propionic acid ethyl ester In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 10h; | 85.4% |
methanesulfonic acid
(4-cyanophenyl)glycine
ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate
Conditions | Yield |
---|---|
Stage #1: (4-cyanophenyl)glycine With 1,1'-carbonyldiimidazole In tetrahydrofuran at 20℃; Stage #2: ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate In tetrahydrofuran at 30 - 35℃; Stage #3: methanesulfonic acid Further stages; | 85% |
Stage #1: (4-cyanophenyl)glycine With 1,1'-carbonyldiimidazole In tetrahydrofuran at 25 - 35℃; for 3h; Stage #2: ethyl 3-{[{2-amino-1-(methylamino)phen-4-yl}carbonyl](pyridyn-2-yl)amino}propanoate In tetrahydrofuran at 25 - 35℃; for 24h; Stage #3: methanesulfonic acid In acetone at 0 - 10℃; for 3h; Concentration; Temperature; | 220 g |
(4-cyanophenyl)glycine
Conditions | Yield |
---|---|
Stage #1: (4-cyanophenyl)glycine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran; N,N-dimethyl-formamide for 0.5h; Cooling with ice; Stage #2: 3-[(3-amino-4-ethylaminobenzoyl)(2,5-dimethyl-phenyl)amino]propionic acid ethyl ester In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 10h; | 84.5% |
(4-cyanophenyl)glycine
Conditions | Yield |
---|---|
Stage #1: (4-cyanophenyl)glycine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran; N,N-dimethyl-formamide for 0.5h; Cooling with ice; Stage #2: ethyl 5-[3-amino-4-(ethylamino)phenyl]-4-(2,5-dimethylphenyl)-5-oxopentanoate In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; | 84.2% |
(4-cyanophenyl)glycine
Conditions | Yield |
---|---|
Stage #1: (4-cyanophenyl)glycine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran; N,N-dimethyl-formamide for 0.5h; Cooling with ice; Stage #2: ethyl 5-[3-amino-4-(ethylamino)phenyl]-4-(3-methylphenyl)-5-oxopentanoate In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; | 83.7% |
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