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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Nipecotic acid Manufacturer/High quality/Best price/In stock

Cas:498-95-3

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Appearance White or yellow crystalline powder Confirm Assay 97

High quality 498-95-3 Nipecotic acid

Cas:498-95-3

Min.Order:1 Kilogram

FOB Price: $1300.0 / 1600.0

Type:Trading Company

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White or almost white crystalline powder Storage:Cool dry place Package:1kg/foill bag;25kg/drum

Nipecotic acid Cas 498-95-3

Cas:498-95-3

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 3-Piperidinecarboxylic Acid

Cas:498-95-3

Min.Order:1

Negotiable

Type:Other

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Anhui Dexinjia Biopharm Co., Ltd

As a leading and professional manufacturer of APIs and API intermediates in China,Anhui Dexinjia Biopharm Co., Ltd founded in 2006, Except for the R&D center, our company has built a close cooperation relation with Chinese Academy of Sciences, T

Nipecotic acid, 98%Min, Manufacturer

Cas:498-95-3

Min.Order:100 Gram

Negotiable

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product description: Product name Nipecotic acid CAS number 498-95-3 Assay ≥97% Appearance White or light yellow crystalline powder Capacity 200mt/year Application Organic sy

Nipecotic acid

Cas:498-95-3

Min.Order:10 Gram

FOB Price: $12.0

Type:Lab/Research institutions

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Nipecotic acid

Cas:498-95-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Nipecotic acid

Cas:498-95-3

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

Nipecotic acid Basic information Product Name: Nipecotic acid Synonyms: (3R)-(-)-PIPERIDIN-3-YLCARBOXYLIC ACID;(+/-)-3-PIPERIDINE CARBOXYLIC ACID;3-PIPERIDINECARBOXYLIC ACID;L-NIPECOTIC

Nipecotic acid 498-95-3

Cas:498-95-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Nipecotic acid

Cas:498-95-3

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Manufacturer supply CAS 498-95-3 with best quality

Cas:498-95-3

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages ♦ High purity, all above 98.5%, no impurities after the dissolution ♦ We will test each batch to ensure quality ♦ OEM and private brand services designed for free ♦ Various cap colors available &diam

Nipecotic acid CAS498-95-3

Cas:498-95-3

Min.Order:1 Kilogram

FOB Price: $7.0 / 10.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

Product Name Nipecotic acid Synonyms DL-Nipecotic acid; 3-Piperidinecarboxylic acid; Piperidin-3-carboxylic acid; H-DL-Nip-OH~(+/-)-Piperidine-3-carboxylic acid; piperidine-3-carboxylic a

Nipecotic acid

Cas:498-95-3

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Nipecotic acid 498-95-3

Cas:498-95-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At prese

Fine Chemical Intermediate,Nipecotic acid CAS:498-95-3

Cas:498-95-3

Min.Order:1 Kilogram

FOB Price: $30.0 / 36.0

Type:Trading Company

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Nipecotic acid

Cas:498-95-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Wuhan Zenuo Biological Medicine Technology Co Ltd

Product Name: Nipecotic acid Synonyms: (3R)-(-)-PIPERIDIN-3-YLCARBOXYLIC ACID;(+/-)-3-PIPERIDINE CARBOXYLIC ACID;3-PIPERIDINECARBOXYLIC ACID;L-NIPECOTIC ACID;DL-NIPECOTIC ACID;DL-3-PIPERIDINECARBOXYLIC ACID;(-)-D-NIPECOTIC ACID;D(-)-NIPECOTIC AC

Nipecotic acid supplier best quality

Cas:498-95-3

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Nipecotic acid

Cas:498-95-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Piperidine-3-carboxylic acid

Cas:498-95-3

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

Name Nipecotic acid Synonyms 3-Piperidinecarboxylic acid Molecular Structure Molecular Formula

Nipecotic acid

Cas:498-95-3

Min.Order:0 Metric Ton

Negotiable

Type:Other

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

NIPECOTIC ACID CAS NO 498-95-3

Cas:498-95-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3-Piperidine-carboxylic acid

Cas:498-95-3

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

2,2-Dimethyl-1-propylamine

Cas:498-95-3

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name:3-Piperidinecarboxylic Acid CAS No.:498-95-3 Molecule Formula:C6H11NO2 Molecule Weight:129.16 Purity: 97.0% Package: 25kg/drum Description:White or yellow crystalline powder Manufacture Standards:Enterprise Standard

High Quality 3-Piperidinecarboxylic Acid

Cas:498-95-3

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Nipecotic acid

Cas:498-95-3

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

H-DL-Nip-OH

Cas:498-95-3

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Nipecotic acid Basic information Product Name: Nipecotic acid Synonyms: L-NIPECOTIC ACID;(3R)-(-)-PIPERIDIN-3-YLCARBOXYLIC ACID;(+/-)-3-PIPERIDINE CARBOXYLIC ACID;3-PIPERIDINECARBOXYLIC ACID;DL-NIPECOTIC ACID;DL-3-PIPERIDINECARBOXYLIC ACID;(-)

Nipecotic acid

Cas:498-95-3

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Piperidine-3-carboxylic acid

Cas:498-95-3

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

Nipecotic acid

Cas:498-95-3

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

methyl 3-pyridinecarboxylate
93-60-7

methyl 3-pyridinecarboxylate

nipecotic acid
498-95-3

nipecotic acid

Conditions
ConditionsYield
With hydrogen In water at 120℃; under 11251.1 Torr; for 1h;100%
nicotinic acid
59-67-6

nicotinic acid

nipecotic acid
498-95-3

nipecotic acid

Conditions
ConditionsYield
With platinum(IV) oxide; hydrogen In ethanol at 80℃; under 6205.94 Torr; for 0.666667h; Microwave irradiation;98%
With ethanol; sodium
With hydrogenchloride; platinum Hydrogenation;
N-benzylnipecotic acid benzyl ester
141943-03-5

N-benzylnipecotic acid benzyl ester

A

1-benzylpiperidine-3-carboxylic acid
141943-04-6

1-benzylpiperidine-3-carboxylic acid

B

nipecotic acid
498-95-3

nipecotic acid

Conditions
ConditionsYield
With cyclohexa-1,4-diene; hydrogen; palladium on activated charcoal In ethanol for 0.166667h; Ambient temperature;A 63%
B 30%
potassium carbonate
584-08-7

potassium carbonate

Ethyl nipecotate
71962-74-8

Ethyl nipecotate

nipecotic acid
498-95-3

nipecotic acid

Conditions
ConditionsYield
With Ki In ethyl acetate; acetone55%
nicotinic acid
59-67-6

nicotinic acid

A

nipecotic acid
498-95-3

nipecotic acid

B

1,4,5,6-tetrahydronicotinate

1,4,5,6-tetrahydronicotinate

Conditions
ConditionsYield
With (S)-1-[(S)-2-(dicyclohexylphosphino)ferrocenyl]ethyldicyclohexylphosphine; hydrogen; di(norbornadiene)rhodium(I) tetrafluoroborate In methanol at 60℃; under 75006 Torr; for 20h; Product distribution; Further Variations:; Reagents;A 8%
B n/a
piperidine
110-89-4

piperidine

formic acid
64-18-6

formic acid

A

isonipecotic acid
498-94-2

isonipecotic acid

B

glycine
56-40-6

glycine

C

pipecolic Acid
4043-87-2

pipecolic Acid

D

nipecotic acid
498-95-3

nipecotic acid

Conditions
ConditionsYield
In water at 10 - 20℃; for 1h; contact glow discharge electrolysis (500-600 V, 45 mA);A 4.3%
B 0.1%
C 0.8%
D 2.9%
Pyridine-2,3-dicarboxylic acid
89-00-9

Pyridine-2,3-dicarboxylic acid

nipecotic acid
498-95-3

nipecotic acid

Conditions
ConditionsYield
With i-Amyl alcohol; sodium
3-methoxycarbonylpiperidine
50585-89-2

3-methoxycarbonylpiperidine

A

dihydroarecoline
1690-72-8

dihydroarecoline

B

nipecotic acid
498-95-3

nipecotic acid

Conditions
ConditionsYield
at 150℃; under 0.01 Torr;
Piperidine-3-carboxylic acid 4-nitro-phenyl ester
119228-39-6

Piperidine-3-carboxylic acid 4-nitro-phenyl ester

A

4-nitro-phenol
100-02-7

4-nitro-phenol

B

nipecotic acid
498-95-3

nipecotic acid

Conditions
ConditionsYield
With water at 37℃; pH 7.4; other nipecotic acid phenyl esters; various solutions;
Piperidine-3-carboxylic acid 4-nitro-phenyl ester; hydrobromide

Piperidine-3-carboxylic acid 4-nitro-phenyl ester; hydrobromide

A

4-nitro-phenol
100-02-7

4-nitro-phenol

B

nipecotic acid
498-95-3

nipecotic acid

Conditions
ConditionsYield
With Cu complex of polymer from 2,6-bis-aminomethylpyridine and 4,4'-bis-aminomethyldiphenylmethane; water In dimethyl sulfoxide at 25℃; Rate constant; var.reag.: Cu(2+) complex of 2,6-bis-benzylaminomethylpyridine; oligomers of 2,6-bis-aminomethylpyridine and 4,4'-bis-aminomethyldiphenylmethane;
1.2.5.6-tetrahydro-pyridine-carboxylic acid-(3)

1.2.5.6-tetrahydro-pyridine-carboxylic acid-(3)

nipecotic acid
498-95-3

nipecotic acid

Conditions
ConditionsYield
With acetic acid; platinum Hydrogenation;
With hydrogenchloride; platinum Hydrogenation;
hydrogenchloride
7647-01-0

hydrogenchloride

guvacine
498-96-4

guvacine

platinum black

platinum black

nipecotic acid
498-95-3

nipecotic acid

Conditions
ConditionsYield
Hydrogenation;
guvacine
498-96-4

guvacine

acetic acid
64-19-7

acetic acid

platinum black

platinum black

nipecotic acid
498-95-3

nipecotic acid

Conditions
ConditionsYield
Hydrogenation;
nicotinic acid
59-67-6

nicotinic acid

ethanol
64-17-5

ethanol

sodium

sodium

nipecotic acid
498-95-3

nipecotic acid

Pyridine-2,3-dicarboxylic acid
89-00-9

Pyridine-2,3-dicarboxylic acid

i-Amyl alcohol
123-51-3

i-Amyl alcohol

sodium

sodium

nipecotic acid
498-95-3

nipecotic acid

water
7732-18-5

water

nicotinic acid hydrochloride
636-79-3

nicotinic acid hydrochloride

platinum oxide

platinum oxide

nipecotic acid
498-95-3

nipecotic acid

Conditions
ConditionsYield
Hydration;
[(2-chloroethoxy)(3,4-chlorophenyl)(phenyl)]methane

[(2-chloroethoxy)(3,4-chlorophenyl)(phenyl)]methane

Ethyl nipecotate
71962-74-8

Ethyl nipecotate

nipecotic acid
498-95-3

nipecotic acid

Conditions
ConditionsYield
Ki; potassium carbonate In N,N-dimethylformamide (DMF); chloroform
Ki; potassium carbonate In N,N-dimethylformamide (DMF); chloroform
C15H36BrNO2Si3

C15H36BrNO2Si3

nipecotic acid
498-95-3

nipecotic acid

Conditions
ConditionsYield
With water; triethylamine In tetrahydrofuran; pentane at -60 - 20℃; for 4h;
4-(4-bromobutylidene)-2,2,6,6-tetramethyl-3,5-dioxa-2,6-disilaheptane

4-(4-bromobutylidene)-2,2,6,6-tetramethyl-3,5-dioxa-2,6-disilaheptane

nipecotic acid
498-95-3

nipecotic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: trimethylsilyl trifluoromethanesulfonate / pentane / 2 h / 20 °C / Inert atmosphere
2: triethylamine; water / tetrahydrofuran; pentane / 4 h / -60 - 20 °C
View Scheme
5-bromopentanoic acid
2067-33-6

5-bromopentanoic acid

nipecotic acid
498-95-3

nipecotic acid

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 - 20 °C / Inert atmosphere
2: trimethylsilyl trifluoromethanesulfonate / pentane / 2 h / 20 °C / Inert atmosphere
3: triethylamine; water / tetrahydrofuran; pentane / 4 h / -60 - 20 °C
View Scheme
2-chloro-5-(5-ethyl-1,3-oxazol-2-yl)-6-methylnicotinonitrile
898229-16-8

2-chloro-5-(5-ethyl-1,3-oxazol-2-yl)-6-methylnicotinonitrile

nipecotic acid
498-95-3

nipecotic acid

1-[3-cyano-5-(5-ethyl-1,3-oxazol-2-yl)-6-methylpyridin-2-yl]piperidine-4-carboxylic acid
898229-21-5

1-[3-cyano-5-(5-ethyl-1,3-oxazol-2-yl)-6-methylpyridin-2-yl]piperidine-4-carboxylic acid

Conditions
ConditionsYield
Stage #1: 2-chloro-5-(5-ethyl-1,3-oxazol-2-yl)-6-methylnicotinonitrile; nipecotic acid With triethylamine In ethanol at 120℃; for 0.333333h; Microwave irradiation;
Stage #2: With hydrogenchloride In water
100%
ethanol
64-17-5

ethanol

nipecotic acid
498-95-3

nipecotic acid

ethyl piperidine-3-carboxylate hydrochloride
4842-86-8

ethyl piperidine-3-carboxylate hydrochloride

Conditions
ConditionsYield
With thionyl chloride at 0℃; Reflux;100%
With thionyl chloride at 0℃; for 24h; Reflux;99%
With thionyl chloride In ethanol at -5℃; for 7h; Heating / reflux;92%
3-amino-2-methylaminopyridine
5028-20-6

3-amino-2-methylaminopyridine

nipecotic acid
498-95-3

nipecotic acid

C12H16N4

C12H16N4

Conditions
ConditionsYield
With polyphosphoric acid at 180℃; for 72h;100%
2,3-Diaminopyridine
452-58-4

2,3-Diaminopyridine

nipecotic acid
498-95-3

nipecotic acid

C11H14N4

C11H14N4

Conditions
ConditionsYield
With polyphosphoric acid at 180℃; for 16h;100%
methanol
67-56-1

methanol

nipecotic acid
498-95-3

nipecotic acid

methyl piperidine-3-carboxylate hydrochloride
89895-55-6

methyl piperidine-3-carboxylate hydrochloride

Conditions
ConditionsYield
With thionyl chloride at 0 - 20℃; for 3h;98%
With thionyl chloride97%
With thionyl chloride
benzyl chloroformate
501-53-1

benzyl chloroformate

nipecotic acid
498-95-3

nipecotic acid

1-benzyloxycarbonylpiperidine-3-carboxylic acid
78190-11-1

1-benzyloxycarbonylpiperidine-3-carboxylic acid

Conditions
ConditionsYield
With sodium hydrogencarbonate In 1,4-dioxane98%
With sodium hydroxide In water at 20℃;89%
With sodium hydroxide82%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

nipecotic acid
498-95-3

nipecotic acid

N-(tert-butyloxycarbonyl)nipecotic acid
71381-75-4, 88495-54-9, 84358-12-3

N-(tert-butyloxycarbonyl)nipecotic acid

Conditions
ConditionsYield
98%
With sodium hydroxide In tert-butyl alcohol at 0 - 20℃; for 12h;97%
With triethylamine In methanol at 0 - 20℃; Inert atmosphere;97%
methanol
67-56-1

methanol

nipecotic acid
498-95-3

nipecotic acid

3-methoxycarbonylpiperidine
50585-89-2

3-methoxycarbonylpiperidine

Conditions
ConditionsYield
With oxalyl dichloride at 0℃; for 1h;98%
With sulfuric acid at 0 - 80℃;
With thionyl chloride at 0℃; for 1h; Inert atmosphere; Reflux;
4-fluoro-7-nitro-2,1,3-benzoxadiazole
29270-56-2

4-fluoro-7-nitro-2,1,3-benzoxadiazole

nipecotic acid
498-95-3

nipecotic acid

rac-1-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)piperidine-3-carboxylic acid

rac-1-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)piperidine-3-carboxylic acid

Conditions
ConditionsYield
With sodium carbonate In water; acetonitrile at 0℃; for 0.116667h; Darkness;98%
benzenesulfonyl chloride
98-09-9

benzenesulfonyl chloride

nipecotic acid
498-95-3

nipecotic acid

1-(phenylsulfonyl)piperidine-3-carboxylic acid
321970-54-1

1-(phenylsulfonyl)piperidine-3-carboxylic acid

Conditions
ConditionsYield
Stage #1: nipecotic acid With sodium carbonate In water at 0℃; for 0.166667h;
Stage #2: benzenesulfonyl chloride In water at 0 - 20℃;
Stage #3: With hydrogenchloride In water at 0 - 5℃; for 0.25 - 0.5h; pH=3;
97.83%
With sodium carbonate In dichloromethane; water at 25℃; for 16h; Inert atmosphere;91%
(E)-5,5-difluoro-7-(5-oxopentenyl)-1,3,10-trimethyl-5Hdipyrrolo[1,2-c:2′,1′-f][1,3,2]diazaborinin-4-ium-5-uide

(E)-5,5-difluoro-7-(5-oxopentenyl)-1,3,10-trimethyl-5Hdipyrrolo[1,2-c:2′,1′-f][1,3,2]diazaborinin-4-ium-5-uide

nipecotic acid
498-95-3

nipecotic acid

rac-(E)-7-{5-[3-(carboxy)piperidin-1-yl]pentenyl}-5,5-difluor-1,3,10-trimethyl-5H-dipyrrolo[1,2-c:2′,1′-f][1,3,2]diazaborinin-4-ium-5-uide

rac-(E)-7-{5-[3-(carboxy)piperidin-1-yl]pentenyl}-5,5-difluor-1,3,10-trimethyl-5H-dipyrrolo[1,2-c:2′,1′-f][1,3,2]diazaborinin-4-ium-5-uide

Conditions
ConditionsYield
Stage #1: (E)-5,5-difluoro-7-(5-oxopentenyl)-1,3,10-trimethyl-5Hdipyrrolo[1,2-c:2′,1′-f][1,3,2]diazaborinin-4-ium-5-uide; nipecotic acid With acetic acid In ethanol at 20℃; for 0.166667h; Inert atmosphere;
Stage #2: With sodium cyanoborohydride In ethanol at 20℃; Inert atmosphere;
96%
formaldehyd
50-00-0

formaldehyd

7-Hydroxy-3-(4-methoxy-phenyl)-chromen-4-on
485-72-3

7-Hydroxy-3-(4-methoxy-phenyl)-chromen-4-on

nipecotic acid
498-95-3

nipecotic acid

1-{[7-hydroxy-3-(4-methoxyphenyl)-4-oxo-4H-chromen-8-yl]methyl}piperidine-3-carboxylic acid
1400917-40-9

1-{[7-hydroxy-3-(4-methoxyphenyl)-4-oxo-4H-chromen-8-yl]methyl}piperidine-3-carboxylic acid

Conditions
ConditionsYield
With dmap In ethanol Mannich Aminomethylation; Reflux; regioselective reaction;95%
benzoyl chloride
98-88-4

benzoyl chloride

nipecotic acid
498-95-3

nipecotic acid

(±)-1-benzoylpiperidine-3-carboxylic acid
13850-76-5

(±)-1-benzoylpiperidine-3-carboxylic acid

Conditions
ConditionsYield
Stage #1: benzoyl chloride; nipecotic acid With potassium carbonate In tetrahydrofuran; water at 0 - 20℃; for 22h;
Stage #2: With hydrogenchloride In water at 0℃; pH=1 - 2;
95%
With potassium carbonate In tetrahydrofuran; water at 0 - 20℃; for 22h;95%
With potassium carbonate In tetrahydrofuran; water at 0 - 20℃; for 22h;95%
Triethyl orthoacetate
78-39-7

Triethyl orthoacetate

nipecotic acid
498-95-3

nipecotic acid

1-acetyl-piperidine-3-carboxylic acid ethyl ester
2637-75-4

1-acetyl-piperidine-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
In toluene at 110℃; for 24h;94%
formaldehyd
50-00-0

formaldehyd

cladrin
24160-14-3

cladrin

nipecotic acid
498-95-3

nipecotic acid

1-{[7-hydroxy-3-(3,4-dimethoxyphenyl)-4-oxo-4H-chromen-8-yl]methyl}piperidine-3-carboxylic acid
1400917-43-2

1-{[7-hydroxy-3-(3,4-dimethoxyphenyl)-4-oxo-4H-chromen-8-yl]methyl}piperidine-3-carboxylic acid

Conditions
ConditionsYield
With dmap In ethanol Mannich Aminomethylation; Reflux; regioselective reaction;92%
Benzyl isothiocyanate
622-78-6

Benzyl isothiocyanate

nipecotic acid
498-95-3

nipecotic acid

(±)-macahydantoins A

(±)-macahydantoins A

Conditions
ConditionsYield
Stage #1: nipecotic acid With pyridine for 0.166667h;
Stage #2: Benzyl isothiocyanate With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride at 65℃; for 8h; Inert atmosphere;
92%
Stage #1: Benzyl isothiocyanate; nipecotic acid With pyridine at 20℃; for 2h;
Stage #2: With dmap; triethylamine; HATU at 20℃; for 6h; Reagent/catalyst; Cooling with ice; Inert atmosphere;
1.172 g
formaldehyd
50-00-0

formaldehyd

5-methylformononetin
128672-43-5

5-methylformononetin

nipecotic acid
498-95-3

nipecotic acid

1-{[7-hydroxy-3-(4-methoxyphenyl)-5-methyl-4-oxo-4H-chromen-8-yl]methyl}piperidine-3-carboxylic acid
1400917-38-5

1-{[7-hydroxy-3-(4-methoxyphenyl)-5-methyl-4-oxo-4H-chromen-8-yl]methyl}piperidine-3-carboxylic acid

Conditions
ConditionsYield
With dmap In ethanol Mannich Aminomethylation; Reflux; regioselective reaction;91%
Boc-Val-ONSu
3392-12-9

Boc-Val-ONSu

nipecotic acid
498-95-3

nipecotic acid

1-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyryl)-piperidine-3-carboxylic acid
208113-87-5

1-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyryl)-piperidine-3-carboxylic acid

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 120℃; for 2.5h;90%
p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

nipecotic acid
498-95-3

nipecotic acid

1-tosylpiperidine-3-carboxylic acid
5134-62-3

1-tosylpiperidine-3-carboxylic acid

Conditions
ConditionsYield
With sodium carbonate In water at 0 - 20℃; for 48h;90%
pentafluorophenyl trifloroacetate
14533-84-7

pentafluorophenyl trifloroacetate

nipecotic acid
498-95-3

nipecotic acid

1-(2,2,2-Trifluoro-acetyl)-piperidine-3-carboxylic acid pentafluorophenyl ester

1-(2,2,2-Trifluoro-acetyl)-piperidine-3-carboxylic acid pentafluorophenyl ester

Conditions
ConditionsYield
With pyridine In N,N-dimethyl-formamide Ambient temperature;89%
nipecotic acid
498-95-3

nipecotic acid

n-hexadecanoyl chloride
112-67-4

n-hexadecanoyl chloride

N-palmitoylpiperidine-3-carboxylic acid

N-palmitoylpiperidine-3-carboxylic acid

Conditions
ConditionsYield
With potassium carbonate In water; acetone at 0 - 20℃;86%
potassium phosphate

potassium phosphate

4-bromo-1-iodo-8,9-dihydro-7H-6-oxa-2,9a-diazabenzo[cd]azulene

4-bromo-1-iodo-8,9-dihydro-7H-6-oxa-2,9a-diazabenzo[cd]azulene

nipecotic acid
498-95-3

nipecotic acid

1-(4-bromo-8,9-dihydro-7H-6-oxa-2,9a-diazabenzo[cd]azulen-1-yl)piperidine-3-carboxylic acid

1-(4-bromo-8,9-dihydro-7H-6-oxa-2,9a-diazabenzo[cd]azulen-1-yl)piperidine-3-carboxylic acid

Conditions
ConditionsYield
With ammonia86%
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-6-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide
1396776-39-8

N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-6-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide

nipecotic acid
498-95-3

nipecotic acid

N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-6-(1-(piperidine-3-carbonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide
1396771-96-2

N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-6-(1-(piperidine-3-carbonyl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide

Conditions
ConditionsYield
Stage #1: N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-6-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide; nipecotic acid With triethylamine In dimethyl sulfoxide at 20℃; for 0.25h;
Stage #2: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate In dimethyl sulfoxide
85%
formic acid
64-18-6

formic acid

nipecotic acid
498-95-3

nipecotic acid

N-formylpiperidine-3-carboxylic acid

N-formylpiperidine-3-carboxylic acid

Conditions
ConditionsYield
Stage #1: formic acid With acetic anhydride for 1h; Heating;
Stage #2: nipecotic acid at 25℃; for 16h;
85%
nipecotic acid
498-95-3

nipecotic acid

methyl iodide
74-88-4

methyl iodide

3-carboxy-1,1-dimethyl-piperidinium; chloride
62581-21-9

3-carboxy-1,1-dimethyl-piperidinium; chloride

Conditions
ConditionsYield
With sodium hydroxide In methanol for 12h; Heating;84%
2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile
58632-95-4

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

nipecotic acid
498-95-3

nipecotic acid

N-(tert-butyloxycarbonyl)nipecotic acid
71381-75-4, 88495-54-9, 84358-12-3

N-(tert-butyloxycarbonyl)nipecotic acid

Conditions
ConditionsYield
With triethylamine In water; acetone81%
With sodium hydrogencarbonate In 1,4-dioxane Acylation;
With triethylamine In water; acetone for 12h;
2'-chlorobiphenyl-3-sulfonyl chloride
933674-72-7

2'-chlorobiphenyl-3-sulfonyl chloride

nipecotic acid
498-95-3

nipecotic acid

C18H18ClNO4S
1394241-89-4

C18H18ClNO4S

Conditions
ConditionsYield
In N,N-dimethyl-formamide; acetone at 0 - 20℃; Inert atmosphere;79%
methanesulfonic acid 2-methoxy-6-pentadecyl-benzyl ester
1361955-58-9

methanesulfonic acid 2-methoxy-6-pentadecyl-benzyl ester

nipecotic acid
498-95-3

nipecotic acid

1-(2-methoxy-6-pentadecylbenzyl)piperidine-3-carboxylic acid
1363400-62-7

1-(2-methoxy-6-pentadecylbenzyl)piperidine-3-carboxylic acid

Conditions
ConditionsYield
With triethylamine In acetonitrile at 85℃;76%

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