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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

5-Formyl-2-methylpyridine

Cas:53014-84-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

6-Methyl-3-pyridinecarboxaldehyde

Cas:53014-84-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Top Purity CAS 53014-84-9 with fast shipping

Cas:53014-84-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

6-methylpyridine-3-carbaldehyde

Cas:53014-84-9

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

3-Pyridinecarboxaldehyde,6-methyl-

Cas:53014-84-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Chemlyte Solutions

Chemlyte Solutions believe that customers and suppliers deserve much more than what traditional distributors can offer. To grow in today s fast-paced and increasingly competitive market it is essential to be able to quickly adapt to market forces eff

Featured products 3-FORMYL-6-METHYL-PYRIDINE

Cas:53014-84-9

Min.Order:100 Gram

Negotiable

Type:Other

inquiry

TaiChem Taizhou Limited

Established in May 2015, TaiChem Ltd. is initially invested by a British research and development company and started by PhDs back from aboard. The company is registered in China Medical City (CMC), Taizhou, Jiangsu Province, and the production site

3-FORMYL-6-METHYL-PYRIDINE

Cas:53014-84-9

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

3-FORMYL-6-METHYL-PYRIDINE 53014-84-9

Cas:53014-84-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

3-FORMYL-6-METHYL-PYRIDINE

Cas:53014-84-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Minstar Chemical Co., Ltd

3-FORMYL-6-METHYL-PYRIDINE Basic information Product Name: 3-FORMYL-6-METHYL-PYRIDINE Synonyms: 6-METHYL-3-PYRIDINECARBOXALDEHYDE;5-FORMYL-2-PICOLINE;3-FORMYL-6-METHYL-PYRIDINE;6-Methylpyridine-3-carboxaldehyde;5-Formyl-2-methylpyridine;6-Methy

3-FORMYL-6-METHYL-PYRIDINE

Cas:53014-84-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

3-FORMYL-6-METHYL-PYRIDINE

Cas:53014-84-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

3-Pyridinecarboxaldehyde,6-methyl-

Cas:53014-84-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shanghai Finebiotech Co.,Ltd.

Shanghai Finebiotech Co.,Ltd.was established in 2020, which providing professional chemical services. As a customer-oriented company, we have distinguished ourself from others in providing worldwide customers with cost-effective and efficient service

6-methylpyridine-3-carbaldehyde

Cas:53014-84-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

6-Methylnicotinaldehyde cas no. 53014-84-9 97%

Cas:53014-84-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Suzhou Sibian Chemical Technology Co., Ltd

The process is mature and can be mass produced to 100 kg, with good quality and purity up to 99%.The product has a large stock and can be supplied stably. Package:bottle Application:Drug R&D Transportation:Sealed drying(25℃) Port:ShangHai

3-FORMYL-6-METHYL-PYRIDINE

Cas:53014-84-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

6-methylpyridine-3-carbaldehyde

Cas:53014-84-9

Min.Order:0

Negotiable

Type:Other

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,or Intermediates,fine chemicals Transportation:air,sea,courier

6-Methylpyridine-3-carboxaldehyde

Cas:53014-84-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

6-Methylpyridine-3-carboxaldehyde

Cas:53014-84-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

2-Methyl-5-formylpyridine

Cas:53014-84-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Hunan chemfish Pharmaceutical co.,Ltd.located in Lugu High-tech industral park ,Hunan province . with its own R&D center and more than 10000㎡manufacture plant . Chemfish owns 40 reactors from 1000L to 8000L. With complete auxiliary equipment as

6-Methylnicotinaldehyde

Cas:53014-84-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

5-FORMYL-2-PICOLINE

Cas:53014-84-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Antimex Chemical Limied

hight degree of purity Application:Fine chemical intermediates, used as the main raw material for he synthesis of various pesticides, medicines, surfactants, polymer monomers, Ond Ontifungal agents

3-Pyridinecarboxaldehyde,6-methyl-

Cas:53014-84-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

BOC Sciences

We are committed to providing our customers with the best products and services at the most competitive prices.Appearance:crystalline powder Storage:Room temperature with sealed well Package:according to the clients requirement Application:Use as pri

5-Formyl-2-methylpyridine

Cas:53014-84-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hangzhou Fandachem Co.,Ltd

5-Formyl-2-methylpyridine cas 53014-84-9Appearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

5-Formyl-2-methylpyridine cas 53014-84-9

Cas:53014-84-9

Min.Order:0

Negotiable

Type:Other

inquiry

Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

3-FORMYL-6-METHYL-PYRIDINE

Cas:53014-84-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SAGECHEM LIMITED

53014-84-9 Application:intermediate

6-methylnicotinaldehyde

Cas:53014-84-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hunan Longxianng Runhui Trading Co.,Ltd

R & D enterprises have their own stock in stockAppearance:To be subject to the object Package:Customized Application:pharmaceutical intermediates Transportation:Air Port:Shanghai;Guangzhou

6-methylnicotinaldehyde

Cas:53014-84-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hunan Russell Chemicals Technology Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:Foil bag; Drum; Plastic bottle Application:Pharma;Industry;Agricultural Transportation:by sea or air Port:any port in China

6-Methylnicotinaldehyde 53014-84-9

Cas:53014-84-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

AstaTech ( Chengdu) BioPharmaceutical Corp.

Quality assurance, stable process and affordable priceAppearance:detailed see specifications Storage:enquiry Package:according to the clients requirement Application:Pharmaceutical intermediates Transportation:Normal Port:chengdu

2-Methyl-5-formylpyridine

Cas:53014-84-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

3-FORMYL-6-METHYL-PYRIDINE

Cas:53014-84-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

6-methyl-3-pyridinemethanol
34107-46-5

6-methyl-3-pyridinemethanol

2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

Conditions
ConditionsYield
Stage #1: 6-methyl-3-pyridinemethanol With oxalyl dichloride; dimethyl sulfoxide In dichloromethane at -60℃; for 1.33333h;
Stage #2: With triethylamine In dichloromethane at -60 - 20℃; for 0.166667h;
85%
With oxalyl dichloride; dimethyl sulfoxide; triethylamine In dichloromethane at -60℃; for 1.5h;85%
With lead(IV) acetate In toluene for 2.5h; Heating;57%
5-bromo-2-methylpyridine
3430-13-5

5-bromo-2-methylpyridine

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

Conditions
ConditionsYield
Stage #1: 5-bromo-2-methylpyridine With n-butyllithium; isopropylmagnesium chloride In tetrahydrofuran; hexane at -10℃; for 0.5h;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at 0℃; for 2h;
85%
Stage #1: 5-bromo-2-methylpyridine With n-butyllithium In tetrahydrofuran at -78℃; for 1h;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at -78℃; for 1h;
72%
Stage #1: 5-bromo-2-methylpyridine With n-butyllithium In tetrahydrofuran at -78℃; for 1h;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at -78℃; for 1h;
72%
Stage #1: 5-bromo-2-methylpyridine With n-butyllithium; isopropylmagnesium chloride In tetrahydrofuran; hexane at 10℃; for 1h;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; hexane at 20℃; for 2h;
38%
Stage #1: 5-bromo-2-methylpyridine With isopropylmagnesium chloride In tetrahydrofuran at 0 - 20℃; for 6h;
Stage #2: N,N-dimethyl-formamide In tetrahydrofuran at 0 - 20℃;
4.5 g
dihydroxy-methyl-borane
13061-96-6

dihydroxy-methyl-borane

6-bromonicotinaldehyde
149806-06-4

6-bromonicotinaldehyde

2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

Conditions
ConditionsYield
16%
6-methyl-pyridine-3-carbaldehyde semicarbazone
106837-80-3

6-methyl-pyridine-3-carbaldehyde semicarbazone

2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

Conditions
ConditionsYield
With hydrogenchloride; water; 3-nitro-benzaldehyde
2,5-dimethylpyridine
589-93-5

2,5-dimethylpyridine

A

5-methylpicolinaldehyde
4985-92-6

5-methylpicolinaldehyde

B

2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

C

carbon oxides

carbon oxides

Conditions
ConditionsYield
β-VO(PO3)2 In gas at 400℃; Product distribution; Rate constant; selectivity of reaction, rates of partial and total oxidation;
N-methoxy-N-methyl-6-methylnicotinamide
221615-71-0

N-methoxy-N-methyl-6-methylnicotinamide

A

2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

B

C5H5NCH2C(NC2H6O)2

C5H5NCH2C(NC2H6O)2

Conditions
ConditionsYield
With diisobutylaluminium hydride In toluene at -20 - -5℃; for 0.5h;
Methyl 6-methylnicotinate
5470-70-2

Methyl 6-methylnicotinate

2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: i-PrMgCl / toluene; tetrahydrofuran / 0.5 h / -10 °C
2: DIBAL-H / toluene / 0.5 h / -20 - -5 °C
View Scheme
Multi-step reaction with 2 steps
1: 75 percent / LAH / diethyl ether / 0.5 h / -78 °C
2: 1.) oxalyl chloride, dimethyl sulfoxide, 2.) triethylamine / 1.) methylene chloride, -60 deg C, 20 min, 2.) from -60 deg C to RT
View Scheme
Stage #1: Methyl 6-methylnicotinate With lithium aluminium tetrahydride In tetrahydrofuran at -78℃; for 4h;
Stage #2: With manganese(IV) oxide In dichloromethane for 6h; Heating / reflux;
ethyl 6-methylnicotinate
21684-59-3

ethyl 6-methylnicotinate

2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 89 percent / sodium bis(2-methoxyethoxy)aluminum hydride / diethyl ether / Heating
2: 57 percent / Pb(OAc)4 / toluene / 2.5 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: lithium aluminium tetrahydride / tetrahydrofuran
View Scheme
Multi-step reaction with 2 steps
1: diethyl ether; water
2: pyridine; water
View Scheme
6-methylnicotinonitrile
3222-48-8

6-methylnicotinonitrile

2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Raney nickel; ethanol / Hydrogenation.unter Zusatz einer wss. Loesung von Semicarbazid-hydrochlorid und Natriumacetat
2: 3-nitro-benzaldehyde; hydrochloric acid; water
View Scheme
2-methyl-5-vinylpyridine
140-76-1

2-methyl-5-vinylpyridine

2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

Conditions
ConditionsYield
With sodium periodate; osmium(VIII) oxide In 1,2-dimethoxyethane; water
N-methoxy-N-methyl-6-methylnicotinamide
221615-71-0

N-methoxy-N-methyl-6-methylnicotinamide

2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

Conditions
ConditionsYield
Stage #1: N-methoxy-N-methyl-6-methylnicotinamide With diisobutylaluminium hydride In hexane; dichloromethane at -10℃; for 0.166667h; Inert atmosphere;
Stage #2: With water In hexane; dichloromethane at 20℃; for 1h;
6-methylnicotinic acid
3222-47-7

6-methylnicotinic acid

2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

Conditions
ConditionsYield
Swern Oxidation;
2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

(3E)-6-methylpyridine-3-carbaldehyde oxime

(3E)-6-methylpyridine-3-carbaldehyde oxime

Conditions
ConditionsYield
With hydroxylamine In methanol; water at 20 - 40℃; for 23h; Inert atmosphere;98%
2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

6-methylnicotinaldehyde oxime
89693-75-4

6-methylnicotinaldehyde oxime

Conditions
ConditionsYield
With hydroxylamine In methanol; water at 20 - 40℃; for 4h;94%
With hydroxylamine In methanol; water at 40℃; for 2h;94%
With hydroxylamine hydrochloride; sodium carbonate In ethanol; water at 20℃;
2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

allylmagnesium bromide
1730-25-2

allylmagnesium bromide

1-(6-methylpyridin-3-yl)but-3-en-1-ol
1566970-97-5

1-(6-methylpyridin-3-yl)but-3-en-1-ol

Conditions
ConditionsYield
In tetrahydrofuran at -40 - -20℃; for 0.166667h;94%
2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

(±)-3,7-dimethyloctanehydrazide

(±)-3,7-dimethyloctanehydrazide

3,7-dimethyl-N'-[(6-methylpyridin-3-yl)methylidene]octanehydrazide

3,7-dimethyl-N'-[(6-methylpyridin-3-yl)methylidene]octanehydrazide

Conditions
ConditionsYield
In methanol Reflux;92%
2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

6‑(1H‑indol‑3‑yl)‑4,5′‑bipyrimidine‑2‑amine

6‑(1H‑indol‑3‑yl)‑4,5′‑bipyrimidine‑2‑amine

(E)‑N‑[6‑(1H‑indol‑3‑yl)‑4,5′‑bipyrimidine‑2‑yl]‑1‑(6‑methylpyridin‑3‑yl)methanimine

(E)‑N‑[6‑(1H‑indol‑3‑yl)‑4,5′‑bipyrimidine‑2‑yl]‑1‑(6‑methylpyridin‑3‑yl)methanimine

Conditions
ConditionsYield
With acetic acid In ethanol for 18h; Reflux;90%
2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

malonic acid dimethyl ester
108-59-8

malonic acid dimethyl ester

dimethyl 2-((6-methylpyridin-3-yl)methylene)malonate

dimethyl 2-((6-methylpyridin-3-yl)methylene)malonate

Conditions
ConditionsYield
With piperidine; acetic acid In toluene at 110℃; for 18h; Schlenk technique; Inert atmosphere; Sealed tube;87%
2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

malonic acid
141-82-2

malonic acid

3-(6-methyl-pyridin-3-yl)-acrylic acid
117830-17-8

3-(6-methyl-pyridin-3-yl)-acrylic acid

Conditions
ConditionsYield
With piperidine In pyridine at 100℃;77%
2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

uracil
66-22-8

uracil

A

5-<(6-methyl-3-pyridinyl)hydroxymethyl>-2,4(1H,3H)-pyrimidinedione
83902-97-0

5-<(6-methyl-3-pyridinyl)hydroxymethyl>-2,4(1H,3H)-pyrimidinedione

B

5,5'-<(6-methyl-3-pyridinyl)methylene>bis(2,4(1H,3H)-pyrimidinedione)
102396-65-6

5,5'-<(6-methyl-3-pyridinyl)methylene>bis(2,4(1H,3H)-pyrimidinedione)

Conditions
ConditionsYield
With hydrogenchloride for 8h; Heating;A 70%
B n/a
2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

ethyl 2-cyanoacetate
105-56-6

ethyl 2-cyanoacetate

ethyl (2E)-2-cyano-3-(6-methylpyridin-3-yl)prop-2-enoate

ethyl (2E)-2-cyano-3-(6-methylpyridin-3-yl)prop-2-enoate

Conditions
ConditionsYield
With piperidine; acetic acid In ethanol at 20℃; for 16h;70%
2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

ethyl acrylate
140-88-5

ethyl acrylate

2-[(hydroxy)(6-methylpyridin-3-yl)methyl] acrylic acid ethyl ester
1362851-35-1

2-[(hydroxy)(6-methylpyridin-3-yl)methyl] acrylic acid ethyl ester

Conditions
ConditionsYield
With 1,4-diaza-bicyclo[2.2.2]octane at 20℃;62%
2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

malonic acid
141-82-2

malonic acid

3-amino-3-(6-methyl-3-pyridyl)propionic acid
252989-81-4

3-amino-3-(6-methyl-3-pyridyl)propionic acid

Conditions
ConditionsYield
With ammonium acetate In ethanol for 6h; Condensation; Heating;61%
With ammonium acetate In ethanol Reflux;
2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

N-{3-[4-amino-1-hydroxy-4-(3,3-dimethylbutyl)-3-oxo-3,4-dihydronaphthalen-2-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide hydrochloride
909106-48-5

N-{3-[4-amino-1-hydroxy-4-(3,3-dimethylbutyl)-3-oxo-3,4-dihydronaphthalen-2-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide hydrochloride

N-[3-(4-(3,3-dimethylbutyl)-1-hydroxy-4-{[(6-methylpyridin-3-yl)methyl]amino}-3-oxo-3,4-dihydronaphthalen-2-yl)-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methanesulfonamide

N-[3-(4-(3,3-dimethylbutyl)-1-hydroxy-4-{[(6-methylpyridin-3-yl)methyl]amino}-3-oxo-3,4-dihydronaphthalen-2-yl)-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methanesulfonamide

Conditions
ConditionsYield
Stage #1: N-{3-[4-amino-1-hydroxy-4-(3,3-dimethylbutyl)-3-oxo-3,4-dihydronaphthalen-2-yl]-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl}methanesulfonamide hydrochloride With N-ethyl-N,N-diisopropylamine In 1,2-dichloro-ethane at 20℃; for 0.0833333h;
Stage #2: 2-methyl-5-formylpyridine With magnesium sulfate In 1,2-dichloro-ethane at 50℃; for 18h;
Stage #3: With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; for 18h;
58%
2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

(bromomethyl)triphenyl phosphonium bromide
1034-49-7

(bromomethyl)triphenyl phosphonium bromide

5-(2-bromovinyl)-2-methylpyridine
1189785-37-2

5-(2-bromovinyl)-2-methylpyridine

Conditions
ConditionsYield
Stage #1: (bromomethyl)triphenyl phosphonium bromide With potassium tert-butylate In tetrahydrofuran at -78 - 0℃; Inert atmosphere;
Stage #2: 2-methyl-5-formylpyridine In tetrahydrofuran at -78℃; for 5h;
56%
2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

1-(7-hydroxy-2-methyl-2-(4-methylpent-3-en-1-yl)-2H-chromen-8-yl)ethan-1-one
54246-37-6

1-(7-hydroxy-2-methyl-2-(4-methylpent-3-en-1-yl)-2H-chromen-8-yl)ethan-1-one

(E)-1-(7-hydroxy-2-methyl-2-(4-methylpent-3-en-1-yl)-2H-chromen-8-yl)-3-(6-methylpyridin-3-yl)prop-2-en-1-one

(E)-1-(7-hydroxy-2-methyl-2-(4-methylpent-3-en-1-yl)-2H-chromen-8-yl)-3-(6-methylpyridin-3-yl)prop-2-en-1-one

Conditions
ConditionsYield
Stage #1: 1-(7-hydroxy-2-methyl-2-(4-methylpent-3-en-1-yl)-2H-chromen-8-yl)ethan-1-one With sodium hydride In tetrahydrofuran at 0 - 20℃;
Stage #2: 2-methyl-5-formylpyridine In tetrahydrofuran at 0 - 30℃;
55%
2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

2-(furan-2-yl)cyclopropanecarbohydrazide

2-(furan-2-yl)cyclopropanecarbohydrazide

(E)-2-(furan-2-yl)-N'-((6-methylpyridin-3-yl)methylene)cyclopropanecarbohydrazide

(E)-2-(furan-2-yl)-N'-((6-methylpyridin-3-yl)methylene)cyclopropanecarbohydrazide

Conditions
ConditionsYield
With zinc(II) oxide In ethanol at 20℃; Reagent/catalyst; Solvent; Green chemistry;51%
2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

sodium chlorodifluoroacetate
1895-39-2

sodium chlorodifluoroacetate

5-(2,2-difluorovinyl)-2-methylpyridine

5-(2,2-difluorovinyl)-2-methylpyridine

Conditions
ConditionsYield
With triphenylphosphine In N,N-dimethyl-formamide at 100℃; Inert atmosphere;46%
2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

isopropylmagnesium chloride
1068-55-9

isopropylmagnesium chloride

1-(6-methylpyridin-3-yl)-2-methylpropan-1-ol

1-(6-methylpyridin-3-yl)-2-methylpropan-1-ol

Conditions
ConditionsYield
With diisopropyl zinc; (2S)-(−)-3-exo-(morpholino)isoborneol In tetrahydrofuran; diethyl ether at 20℃; for 1h; Inert atmosphere; Schlenk technique;39%
In tetrahydrofuran Inert atmosphere;
2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

2-(4-(piperazin-1-yl)phenyl)benzo[d]oxazole
885275-02-5

2-(4-(piperazin-1-yl)phenyl)benzo[d]oxazole

2-(4-(4-((6-methylpyridin-3-yl)methyl)piperazin-1-yl)phenyl)benzo[d]oxazole
1426259-87-1

2-(4-(4-((6-methylpyridin-3-yl)methyl)piperazin-1-yl)phenyl)benzo[d]oxazole

Conditions
ConditionsYield
With formic acid In N,N-dimethyl-formamide at 100℃; for 3h; Inert atmosphere;38%
2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

4-[(4-{5-[(piperidin-4-yl)methoxy]pyridine-2-carbonyl}-piperazin-1-yl)methyl]benzonitrile

4-[(4-{5-[(piperidin-4-yl)methoxy]pyridine-2-carbonyl}-piperazin-1-yl)methyl]benzonitrile

4-({4-[5-({1-[(6-methylpyridin-3-yl)methyl]piperidin-4-yl}methoxy)pyridine-2-carbonyl]piperazin-1-yl}methyl)-benzonitrile tetrahydrochloride

4-({4-[5-({1-[(6-methylpyridin-3-yl)methyl]piperidin-4-yl}methoxy)pyridine-2-carbonyl]piperazin-1-yl}methyl)-benzonitrile tetrahydrochloride

Conditions
ConditionsYield
Stage #1: 2-methyl-5-formylpyridine; 4-[(4-{5-[(piperidin-4-yl)methoxy]pyridine-2-carbonyl}-piperazin-1-yl)methyl]benzonitrile With sodium tris(acetoxy)borohydride; acetic acid In dichloromethane at 20℃;
Stage #2: With hydrogenchloride In 1,4-dioxane; methanol
38%
2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

(Z)-5-((2-(4-(aminomethyl)piperidin-1-yl)pyrimidin-4-yl)methylene)thiazolidine-2,4-dione
1312662-54-6

(Z)-5-((2-(4-(aminomethyl)piperidin-1-yl)pyrimidin-4-yl)methylene)thiazolidine-2,4-dione

trifluoroacetic acid
76-05-1

trifluoroacetic acid

(Z)-5-((2-(4-((((6-methylpyridin-3-yl)methyl)amino)methyl)piperidin-1-yl)pyrimidin-4-yl)methylene)thiazolidine-2,4-dione trifluoroacetate

(Z)-5-((2-(4-((((6-methylpyridin-3-yl)methyl)amino)methyl)piperidin-1-yl)pyrimidin-4-yl)methylene)thiazolidine-2,4-dione trifluoroacetate

Conditions
ConditionsYield
Stage #1: 2-methyl-5-formylpyridine; (Z)-5-((2-(4-(aminomethyl)piperidin-1-yl)pyrimidin-4-yl)methylene)thiazolidine-2,4-dione With N-ethyl-N,N-diisopropylamine In cis-1,2-Dichloroethylene; N,N-dimethyl-formamide at 20℃; for 1h;
Stage #2: With sodium tris(acetoxy)borohydride In cis-1,2-Dichloroethylene; N,N-dimethyl-formamide at 20℃; for 16h;
Stage #3: trifluoroacetic acid In cis-1,2-Dichloroethylene for 24h;
37.2%
2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

C27H31N7O3

C27H31N7O3

C29H30N8O

C29H30N8O

Conditions
ConditionsYield
Stage #1: C27H31N7O3 With trifluoroacetic acid In dichloromethane at 20℃; for 3h;
Stage #2: 2-methyl-5-formylpyridine With acetic acid at 20℃; for 0.5h;
Stage #3: With sodium tris(acetoxy)borohydride at 20℃;
36%
2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

2-{[4-tert-butyl-5-(1H-1,2,4-triazol-1-yl)-1,3-thiazol-2-yl]imino}-1,3-thiazolidin-4-one

2-{[4-tert-butyl-5-(1H-1,2,4-triazol-1-yl)-1,3-thiazol-2-yl]imino}-1,3-thiazolidin-4-one

2-{(4-tert-butyl-5-(1H-1,2,4-triazol-1-yl)thiazole-2-yl)imino}-5-[(6-methylpyridin-3-yl)methylidene]-4-thiazolidinone

2-{(4-tert-butyl-5-(1H-1,2,4-triazol-1-yl)thiazole-2-yl)imino}-5-[(6-methylpyridin-3-yl)methylidene]-4-thiazolidinone

Conditions
ConditionsYield
With sodium acetate; acetic acid for 10h; Reflux;33%
2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

4,5-diamino-6-chloro-N4-methylpyrimidine
52602-68-3

4,5-diamino-6-chloro-N4-methylpyrimidine

6-chloro-9-methyl-8-(6-methylpyridin-3-yl)-9H-purine

6-chloro-9-methyl-8-(6-methylpyridin-3-yl)-9H-purine

Conditions
ConditionsYield
With iron(III) chloride hexahydrate In N,N-dimethyl-formamide at 90℃; for 16h;33%
2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

diethylamine
109-89-7

diethylamine

N-ethyl-N-((6-methylpyridin-3-yl)methyl)ethanamine

N-ethyl-N-((6-methylpyridin-3-yl)methyl)ethanamine

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride In 1,2-dichloro-ethane for 16h;31%
2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

(-)-2-((3,4-trans)-4-methylpyrrolidin-3-yl)-7-(tetrahydro-2H-pyran-4-yl)imidazo[5,1-f][1,2,4]triazin-4(3H)-one

(-)-2-((3,4-trans)-4-methylpyrrolidin-3-yl)-7-(tetrahydro-2H-pyran-4-yl)imidazo[5,1-f][1,2,4]triazin-4(3H)-one

(+)-2-((3,4-trans)-4-methyl-1-((6-methylpyridin-3-yl)methyl)pyrrolidin-3-yl)-7-(tetrahydro-2H-pyran-4-yl)imidazo[5,1-f][1,2,4]triazin-4(3H)-one

(+)-2-((3,4-trans)-4-methyl-1-((6-methylpyridin-3-yl)methyl)pyrrolidin-3-yl)-7-(tetrahydro-2H-pyran-4-yl)imidazo[5,1-f][1,2,4]triazin-4(3H)-one

Conditions
ConditionsYield
Stage #1: 2-methyl-5-formylpyridine; (-)-2-((3,4-trans)-4-methylpyrrolidin-3-yl)-7-(tetrahydro-2H-pyran-4-yl)imidazo[5,1-f][1,2,4]triazin-4(3H)-one With methanol at 20℃; for 2h; Inert atmosphere;
Stage #2: With sodium cyanoborohydride at 20℃; for 8h; Inert atmosphere;
21%
2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

2-amino-N-(4-(methylthio)phenyl)benzamide

2-amino-N-(4-(methylthio)phenyl)benzamide

2-(6-methylpyridin-3-yl)-3-(4-(methylthio)phenyl)quinazolin-4(3H)-one
1235480-42-8

2-(6-methylpyridin-3-yl)-3-(4-(methylthio)phenyl)quinazolin-4(3H)-one

Conditions
ConditionsYield
With copper dichloride In ethanol for 6h; Reflux;19%
2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

2-amino-N-(4-cyclopropylphenyl)benzamide
1235480-97-3

2-amino-N-(4-cyclopropylphenyl)benzamide

3-(4-cyclopropylphenyl)-2-(6-methylpyridin-3-yl)quinazolin-4(3H)-one
1235480-46-2

3-(4-cyclopropylphenyl)-2-(6-methylpyridin-3-yl)quinazolin-4(3H)-one

Conditions
ConditionsYield
With copper dichloride In ethanol for 2.5h; Reflux;15%

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