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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

1-(4-Chlorophenyl)-1-phenylethanol

Cas:59767-24-7

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 1-(4-Chlorophenyl)-1-phenylethanol

Cas:59767-24-7

Min.Order:1

Negotiable

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Product Name: 1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL Synonyms: 1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL;1-(p-Chlorophenyl)-1-phenylethanol;4-Chloro-α-methyl-α-phenylbenzenemethanol;α-Methyl-α-phenyl-4-chlorobenzenemet

59767-24-7 1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL

Cas:59767-24-7

Min.Order:1 Kilogram

FOB Price: $8900.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 59767-24-7 with best quality

Cas:59767-24-7

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Factory Supply High Quality CAS 59767-24-7 ,1-(4-chlorophenyl)-1-phenylethanol

Cas:59767-24-7

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

1-(4-Chlorophenyl)-1-phenylethanol 59767-24-7

Cas:59767-24-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Win-Win chemical Co.Ltd

Stock products, own laboratory Appearance:Colourless to Light Yellow Oil Storage:normal Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:shanghai

1-(4-Chlorophenyl)-1-phenylethanol Cas no.59767-24-7 98%

Cas:59767-24-7

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL CAS:59767-24-7 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qual

1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL CAS:59767-24-7

Cas:59767-24-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1-(4-Chlorophenyl)-1-phenylethanol

Cas:59767-24-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

1-(4-Chlorophenyl)-1-phenylethanol

Cas:59767-24-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

1-(4-chlorophenyl)-1-phenylethanol

Cas:59767-24-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL

Cas:59767-24-7

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Saiwante (shanghai) New Material Technology Co., Ltd.

ProName: 1-(4-Chlorophenyl)-1-phenylethanol CasNo: 59767-24-7 Molecular Formula: C14H13ClO Appearance: detailed see specifications Application: It is an important raw material and in... DeliveryTime: prompt PackAge: according to the clients r

1-(4-Chlorophenyl)-1-phenylethanol

Cas:59767-24-7

Min.Order:1 Gram

FOB Price: $6.0 / 9.0

Type:Trading Company

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

advantage: 1. The best price, satisfactory quality; 2. customers have the right to choose the delivery of parcels (EMS, DHL, FedEx, UPS); 3. customers have the right to choose from the recent effective packaging methods of their products packaging

1(4-Chlorophenyl)-1-phenylethanol

Cas:59767-24-7

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

1-(4-Chlorophenyl)-1-phenylethanol

Cas:59767-24-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

1-(4-Chlorophenyl)-1-phenylethanol

Cas:59767-24-7

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

1-(4-chlorophenyl)-1-phenylethanol

Cas:59767-24-7

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

Type:Lab/Research institutions

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

1-(4-Chlorophenyl)-1-phenylethanol

Cas:59767-24-7

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

1-(4-CHLOROPHENYL)-1-PHENYLETHANOL

Cas:59767-24-7

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

SAGECHEM/ 1-(4-Chlorophenyl)-1-phenylethanol /Manufacturer in China

Cas:59767-24-7

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL

Cas:59767-24-7

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

SAGECHEM/ 1-(4-Chlorophenyl)-1-phenylethanol /Manufacturer in China

Cas:59767-24-7

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

SAGECHEM LIMITED

SAGECHEM is a chemical R&D, manufacturing and distribution company in China since 2009, including pharmaceutical intermediates, agrochemical, dyestuff intermediates, organosilicone, API and etc. We also offer a full range of services in

SAGECHEM/ 1-(4-Chlorophenyl)-1-phenylethanol /Manufacturer in China

Cas:59767-24-7

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

SAGECHEM/ 1-(4-Chlorophenyl)-1-phenylethanol /Manufacturer in China

Cas:59767-24-7

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Trading Company

inquiry

GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

1-(4-chlorophenyl)-1-phenylethanol

Cas:59767-24-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Henan Allgreen Chemical Co.,Ltd

high quality Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Organic synthesis Transportation:by air or by sea

1-(4-Chlorophenyl)-1-phenylethanol

Cas:59767-24-7

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hebei Sankai Chemical Technology Co., Ltd

1. Product advantages? High purity, all above 98.5%, no impurities after dissolution? We will test each batch to ensure quality? OEM and private brand services designed for free? Various cap colors available? We can also provide MT1 peptide powder2.

1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL

Cas:59767-24-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Antimex Chemical Limied

1-(4-Chlorophenyl)-1-phenylethanolAppearance:detailed see specifications Storage:Keep away of light, cool place Package:25kg/drum;200kg/drum Application:It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agro

1-(4-Chlorophenyl)-1-phenylethanol

Cas:59767-24-7

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

HANGZHOU TIANYE CHEMICALS CO., LTD.

We product this chemical more than 10 years . We are very experience to export it to many countries, Our superior & stable quality , competitive price gain warm reception from our customers. Application:Chemical intermediate

1-(4-Chlorophenyl)-1-phenylethanol

Cas:59767-24-7

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Hubei Langyou International Trading Co., Ltd

SAGECHEM/ 1-(4-Chlorophenyl)-1-phenylethanol /Manufacturer in China Application:SAGECHEM/ 1-(4-Chlorophenyl)-1-phenylethanol /Manufacturer in China

SAGECHEM/ 1-(4-Chlorophenyl)-1-phenylethanol /Manufacturer in China

Cas:59767-24-7

Min.Order:0

Negotiable

Type:Other

inquiry

Synthetic route

sodium tetraphenyl borate
143-66-8

sodium tetraphenyl borate

para-chloroacetophenone
99-91-2

para-chloroacetophenone

1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

Conditions
ConditionsYield
With chloro(η4-1,5-cyclooctadiene){1,3-bis(4-methylbenzyl)perhydrobenzimidazolin-2-ylidene}rhodium(I); ammonium chloride In o-xylene at 120℃; for 25h; Reagent/catalyst; Schlenk technique;98%
With ammonium chloride; chloro(1,5-cyclooctadiene)rhodium(I) dimer In o-xylene at 120℃; for 25h;
para-chloroacetophenone
99-91-2

para-chloroacetophenone

phenyltriisopropoxytitanium(IV)
16635-23-7

phenyltriisopropoxytitanium(IV)

1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

Conditions
ConditionsYield
In diethyl ether for 5h; -20 deg C to r.t.;95%
(4-chlorphenyl)magnesium bromide
873-77-8

(4-chlorphenyl)magnesium bromide

acetophenone
98-86-2

acetophenone

1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 0.55h; Grignard reaction; Inert atmosphere;95%
para-chloroacetophenone
99-91-2

para-chloroacetophenone

phenylmagnesium bromide
100-58-3

phenylmagnesium bromide

1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

Conditions
ConditionsYield
Stage #1: phenylmagnesium bromide With Et2AlBr In tetrahydrofuran at 0 - 20℃; Inert atmosphere;
Stage #2: With titanium(IV) isopropylate; (S)-[1,1']-binaphthalenyl-2,2'-diol In toluene at 0℃; for 0.5h; Inert atmosphere;
Stage #3: para-chloroacetophenone Further stages;
90%
In tetrahydrofuran; diethyl ether at 20℃; Grignard Reaction; Inert atmosphere;51%
With ammonium chloride In tetrahydrofuran
In tetrahydrofuran at 0℃; Grignard Reaction; Inert atmosphere;
methyl carbamic acid 1-(4-chlorophenyl)-1-phenylethyl ester
1118917-34-2

methyl carbamic acid 1-(4-chlorophenyl)-1-phenylethyl ester

1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

Conditions
ConditionsYield
With sodium ethanolate In ethanol at 78℃;77%
methyltriisopropoxytitanium(IV)
18006-13-8

methyltriisopropoxytitanium(IV)

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

Conditions
ConditionsYield
In diethyl ether for 20h; -20 deg C to r.t.;50%
bromobenzene
108-86-1

bromobenzene

para-chloroacetophenone
99-91-2

para-chloroacetophenone

1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

Conditions
ConditionsYield
Stage #1: bromobenzene With magnesium; iodine In tetrahydrofuran Inert atmosphere; Reflux;
Stage #2: para-chloroacetophenone In tetrahydrofuran at 0 - 20℃;
Stage #3: With water; ammonium chloride In tetrahydrofuran at 0℃;
25%
1-(p-chlorophenyl)ethyl alcohol
3391-10-4

1-(p-chlorophenyl)ethyl alcohol

phenylmagnesium chloride

phenylmagnesium chloride

1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

1-(p-chlorophenyl)ethyl alcohol
3391-10-4

1-(p-chlorophenyl)ethyl alcohol

phenylmagnesium bromide

phenylmagnesium bromide

1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

methylmagnesium chloride
676-58-4

methylmagnesium chloride

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

Conditions
ConditionsYield
With diethyl ether
methanol
67-56-1

methanol

A

2-(1-methyl-2-pyrrolidine)ethanol
67004-64-2

2-(1-methyl-2-pyrrolidine)ethanol

B

1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

C

1-Chloro-4-(1-methoxy-1-phenyl-ethyl)-benzene

1-Chloro-4-(1-methoxy-1-phenyl-ethyl)-benzene

Conditions
ConditionsYield
Ambient temperature; 6 weeks;
propan-1-ol
71-23-8

propan-1-ol

A

2-(1-methyl-2-pyrrolidine)ethanol
67004-64-2

2-(1-methyl-2-pyrrolidine)ethanol

B

1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

C

1-Phenyl-1-(4-chlorphenyl)-ethylenglycol
28523-14-0

1-Phenyl-1-(4-chlorphenyl)-ethylenglycol

D

1-methyl-2-vinylpyrrolidine
85151-07-1

1-methyl-2-vinylpyrrolidine

E

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

F

1-Phenyl-1-(4-chlorphenyl)-1-n-propoxyethan
117932-40-8

1-Phenyl-1-(4-chlorphenyl)-1-n-propoxyethan

Conditions
ConditionsYield
With sodium hydroxide for 53h; Heating; further time and temp.; also without n-propanol, with H2O or HCl addition;
ethanol
64-17-5

ethanol

A

2-(1-methyl-2-pyrrolidine)ethanol
67004-64-2

2-(1-methyl-2-pyrrolidine)ethanol

B

1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

C

1-Chloro-4-(1-ethoxy-1-phenyl-ethyl)-benzene
87273-95-8

1-Chloro-4-(1-ethoxy-1-phenyl-ethyl)-benzene

Conditions
ConditionsYield
Ambient temperature; 6 weeks;
methyllithium
917-54-4

methyllithium

A

1,1-diphenylethanol
599-67-7

1,1-diphenylethanol

B

1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

Conditions
ConditionsYield
In diethyl ether at 0℃; competition reaction with bezophenone and 4-chlorobenzophenone, relative velocity constant;
methyllithium
917-54-4

methyllithium

C6H5BrMn
109603-92-1

C6H5BrMn

4-chloro-benzoyl chloride
122-01-0

4-chloro-benzoyl chloride

1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

Conditions
ConditionsYield
1.) 0 to 20 deg C, 1.5 h; 2.) 0 to 20 deg C, 2.5 h; Yield given. Multistep reaction;
methylmagnesium bromide
75-16-1

methylmagnesium bromide

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

Conditions
ConditionsYield
0 deg C then 20 deg C, 4h; Yield given;

A

2-(1-methyl-2-pyrrolidine)ethanol
67004-64-2

2-(1-methyl-2-pyrrolidine)ethanol

B

1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

C

1-Phenyl-1-(4-chlorphenyl)-ethylenglycol
28523-14-0

1-Phenyl-1-(4-chlorphenyl)-ethylenglycol

D

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

Conditions
ConditionsYield
With water Heating;
Clemastin-hydrogenfumarat
63537-12-2

Clemastin-hydrogenfumarat

A

2-(1-methyl-2-pyrrolidine)ethanol
67004-64-2

2-(1-methyl-2-pyrrolidine)ethanol

B

1-(4-chlorophenyl)-1-phenylethene
18218-20-7

1-(4-chlorophenyl)-1-phenylethene

C

1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

D

1-(4-Chlorphenyl)-1-(4'-hydroxyphenyl)ethen
110203-93-5

1-(4-Chlorphenyl)-1-(4'-hydroxyphenyl)ethen

E

1-(4-Chlorphenyl)-1-(4'-hydroxyphenyl)ethanol

1-(4-Chlorphenyl)-1-(4'-hydroxyphenyl)ethanol

F

4-{1-(4-Chloro-phenyl)-1-[2-(1-methyl-pyrrolidin-2-yl)-ethoxy]-ethyl}-phenol

4-{1-(4-Chloro-phenyl)-1-[2-(1-methyl-pyrrolidin-2-yl)-ethoxy]-ethyl}-phenol

Conditions
ConditionsYield
With 1H-imidazole; water; dihydrogen peroxide; MnTPFPS4PCl In methanol; dichloromethane at 20℃; for 24h; Product distribution; also without water, var. catalyst;
Clemastin-hydrogenfumarat
63537-12-2

Clemastin-hydrogenfumarat

A

2-(1-methyl-2-pyrrolidine)ethanol
67004-64-2

2-(1-methyl-2-pyrrolidine)ethanol

B

1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

C

2-{2-[1-(4-Chloro-phenyl)-1-phenyl-ethoxy]-ethyl}-pyrrolidine

2-{2-[1-(4-Chloro-phenyl)-1-phenyl-ethoxy]-ethyl}-pyrrolidine

D

Clemastin-N-oxid

Clemastin-N-oxid

Conditions
ConditionsYield
With 1H-imidazole; dihydrogen peroxide; manganese(III)-5,10,15,20-tetrakis(pentafluorophenyl)porphyrin chloride In methanol; dichloromethane at 20℃; for 24h; Further byproducts given;
Clemastin-hydrogenfumarat
63537-12-2

Clemastin-hydrogenfumarat

A

1-(4-chlorophenyl)-1-phenylethene
18218-20-7

1-(4-chlorophenyl)-1-phenylethene

B

1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

C

2-{2-[1-(4-Chloro-phenyl)-1-phenyl-ethoxy]-ethyl}-pyrrolidine

2-{2-[1-(4-Chloro-phenyl)-1-phenyl-ethoxy]-ethyl}-pyrrolidine

D

Clemastin-N-oxid

Clemastin-N-oxid

Conditions
ConditionsYield
With 1H-imidazole; dihydrogen peroxide; manganese(III)-5,10,15,20-tetrakis(pentafluorophenyl)porphyrin chloride In methanol; dichloromethane at 20℃; for 24h; Further byproducts given;
methyllithium
917-54-4

methyllithium

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

Conditions
ConditionsYield
In diethyl ether at 0℃;
4-chloro-benzoyl chloride
122-01-0

4-chloro-benzoyl chloride

1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) anhydr. manganese bromide / 1.) 0 deg C then 20 deg C, 45 min; 2.) 0 deg C then 20 deg C, 1.5 h
2: 0 deg C then 20 deg C, 4h
View Scheme
phenyllithium
591-51-5

phenyllithium

1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) anhydr. manganese bromide / 1.) 0 deg C then 20 deg C, 45 min; 2.) 0 deg C then 20 deg C, 1.5 h
2: 0 deg C then 20 deg C, 4h
View Scheme
bromochlorobenzene
106-39-8

bromochlorobenzene

acetophenone
98-86-2

acetophenone

1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

Conditions
ConditionsYield
Stage #1: bromochlorobenzene With magnesium In tetrahydrofuran
Stage #2: acetophenone In tetrahydrofuran at 0℃; for 2h;
methyl magnesium iodide
917-64-6

methyl magnesium iodide

4-chlorobenzophenone
134-85-0

4-chlorobenzophenone

1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

Conditions
ConditionsYield
In tetrahydrofuran; diethyl ether at 0 - 20℃; Schlenk technique; Inert atmosphere;
1-(4-chlorophenyl)-1-phenylethene
18218-20-7

1-(4-chlorophenyl)-1-phenylethene

1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

Conditions
ConditionsYield
With oxygen; potassium carbonate; isopropyl alcohol at 150℃; under 3000.3 Torr; for 12h; regioselective reaction;> 99 %Chromat.
1-(2-Chloroethyl)-4-ethoxycarbonylpiperazine
64822-11-3

1-(2-Chloroethyl)-4-ethoxycarbonylpiperazine

1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

4-{2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl}-1-(ethoxycarbonyl)piperazine
101620-46-6

4-{2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl}-1-(ethoxycarbonyl)piperazine

Conditions
ConditionsYield
89%
89%
2-(2-chloro-ethyl)-1-methyl-pyrrolidine
54777-54-7, 61771-17-3, 63527-58-2, 67529-19-5

2-(2-chloro-ethyl)-1-methyl-pyrrolidine

succinic acid
110-15-6

succinic acid

1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

clemastine succinate

clemastine succinate

Conditions
ConditionsYield
Stage #1: 2-(2-chloro-ethyl)-1-methyl-pyrrolidine; 1-(4-chloro-phenyl)-1-phenyl-ethanol With sodium amide In toluene at 80℃; Large scale;
Stage #2: succinic acid In ethyl acetate at 60 - 65℃; for 0.5h; Large scale;
55%
dimethyl 2-phenyl-1,1-cyclopropanedicarboxylate
3709-20-4

dimethyl 2-phenyl-1,1-cyclopropanedicarboxylate

1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

(Z)-dimethyl 2-(4-(4-chlorophenyl)-2,4-diphenylbut-3-en-1-yl)malonate

(Z)-dimethyl 2-(4-(4-chlorophenyl)-2,4-diphenylbut-3-en-1-yl)malonate

Conditions
ConditionsYield
With scandium tris(trifluoromethanesulfonate) In dichloromethane at 80℃; Sealed tube; diastereoselective reaction;42%
(+)-(R)-2-(2-chloroethyl)-1-methylpyrrolidine hydrochloride
67499-71-2

(+)-(R)-2-(2-chloroethyl)-1-methylpyrrolidine hydrochloride

1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

(R)-2-[2-[1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine
1174565-35-5

(R)-2-[2-[1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine

Conditions
ConditionsYield
With sodium amide In toluene for 8h; Reflux;36%
1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

(-)-(S)-2-(2-chloroethyl)-1-methylpyrrolidine

(-)-(S)-2-(2-chloroethyl)-1-methylpyrrolidine

A

4-[1-(4-Chloro-phenyl)-1-phenyl-ethoxy]-1-methyl-azepane
61771-18-4

4-[1-(4-Chloro-phenyl)-1-phenyl-ethoxy]-1-methyl-azepane

B

(S)-2-(2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl)-1-methylpyrrolidine
61826-31-1

(S)-2-(2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl)-1-methylpyrrolidine

C

(S)-2-(2-[(1S)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl)-1-methylpyrrolidine

(S)-2-(2-[(1S)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl)-1-methylpyrrolidine

Conditions
ConditionsYield
Stage #1: 1-(4-chloro-phenyl)-1-phenyl-ethanol With sodium hydride In toluene; mineral oil for 3h; Reflux;
Stage #2: (-)-(S)-2-(2-chloroethyl)-1-methylpyrrolidine In toluene; mineral oil at 20℃; Reflux; Inert atmosphere;
A 15%
B n/a
C n/a
2-(piperidin-4-yl)ethyl chloride
1932-03-2

2-(piperidin-4-yl)ethyl chloride

1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

1-{2-[1-(4-chloro-phenyl)-1-phenyl-ethoxy]-ethyl}-piperidine
102071-02-3

1-{2-[1-(4-chloro-phenyl)-1-phenyl-ethoxy]-ethyl}-piperidine

Conditions
ConditionsYield
With sodium amide; toluene
With sodium amide; toluene
1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

p-Tolylisocyanate
622-58-2

p-Tolylisocyanate

p-Tolyl-carbamic acid 1-(4-chloro-phenyl)-1-phenyl-ethyl ester
90862-22-9

p-Tolyl-carbamic acid 1-(4-chloro-phenyl)-1-phenyl-ethyl ester

Conditions
ConditionsYield
With stannous octoate In toluene at 60℃;
1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

2-(dimethylamino)ethyl chloride
107-99-3

2-(dimethylamino)ethyl chloride

chlorphenoxamine
77-38-3

chlorphenoxamine

Conditions
ConditionsYield
With sodium amide In toluene for 4h; Heating; Yield given;
1-(4-chloro-phenyl)-1-phenyl-ethanol
59767-24-7

1-(4-chloro-phenyl)-1-phenyl-ethanol

4-nitro-benzoyl chloride
122-04-3

4-nitro-benzoyl chloride

4-nitro-benzoic acid 1-(4-chloro-phenyl)-1-phenyl-ethyl ester
460742-55-6

4-nitro-benzoic acid 1-(4-chloro-phenyl)-1-phenyl-ethyl ester

Conditions
ConditionsYield
With n-butyllithium In tetrahydrofuran; hexane at -30 - 20℃;

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