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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Gabapentin-lactam

Cas:64744-50-9

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 3,3-Pentamethylene-4-Butyrolactam(Cdi) supplier in China

Cas:64744-50-9

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

inquiry

Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 3,3-pentamethylene-4-butyrolactam

Cas:64744-50-9

Min.Order:1

Negotiable

Type:Other

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

3,3-Pentamethylene 4-butyrolactam

Cas:64744-50-9

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Gabapentin-lactam

Cas:64744-50-9

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

Gabapentin-lactam

Cas:64744-50-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Factory direct supply CAS 64744-50-9 with best quality

Cas:64744-50-9

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Shijiazhuang Sdyano Fine Chemical Co., Ltd

1. Best prices with satisfied quality; 2. It's clients' right to choose the package's Courier (EMS, DHL, FedEx, UPS); 3.It's clients' right to choose the packing way for his produccts from many recent effective packing ways;

Gabapentin-lactam

Cas:64744-50-9

Min.Order:0 Metric Ton

Negotiable

Type:Trading Company

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Gabapentin-lactam 64744-50-9

Cas:64744-50-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Gabapentin-lactam CAS:64744-50-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic interme

Gabapentin-lactam CAS:64744-50-9

Cas:64744-50-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Gabapentin-lactam

Cas:64744-50-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hebei Mojin Biotechnology Co.,Ltd

Hebei Mojin Biotechnology Co., Ltd,Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all em

Gabapentin-Lactam CAS 64744-50-9

Cas:64744-50-9

Min.Order:1 Gram

FOB Price: $95.0 / 100.0

Type:Trading Company

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Gabapentin-lactam

Cas:64744-50-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

3,3-Pentamethylene-4-Butyrolactam

Cas:64744-50-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

Gabapentin-lactam

Cas:64744-50-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Gabapentin-lactam

Cas:64744-50-9

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Gabapentin-lactam

Cas:64744-50-9

Min.Order:10 Kilogram

Negotiable

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Gabapentin-lactam

Cas:64744-50-9

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High quality 3,3-Pentamethylene-4-Butyrolactam(Cdi)

Cas:64744-50-9

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

inquiry

Hangzhou Lingrui Chemical Co.,Ltd.

3,3-Pentamethylene-4-butyrolactam(CDI)Appearance:Colorless transparent liquid Storage:Keep away of light, cool place Package:according to customers' requirements Application:pharmaceutical intermediates Transportation:By air(EMS or EUB or FedEx or TN

3,3-Pentamethylene-4-butyrolactam(CDI)

Cas:64744-50-9

Min.Order:1 Gram

Negotiable

Type:Other

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white solid Storage:Stored in cool, dry and ventilation place; Away from fire and heat Package:10g/bag,or as your request Application:For medicine , pesticide intermediates Transport

Gabapentin-lactam

Cas:64744-50-9

Min.Order:1 Gram

Negotiable

Type:Trading Company

inquiry

Siwei Development Group Ltd.

Product name: 3,3-Pentamethylene-4-Butyrolactam CAS No.: 64744-50-9 Molecule Formula:C9H15NO Molecule Weight:153.22 Purity: 99.0% Package: 25kg/drum Description:White crystalline powder Manufacture Standards:Enterprise Standard

Lower Price 3,3-Pentamethylene-4-Butyrolactam

Cas:64744-50-9

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

Gabapentin-lactam

Cas:64744-50-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Xiamen Jenny Chemical Technology Co., Ltd.

GMP standard, high purity, competitive price, in stock 1. Quick Response: within 6 hours after receiving your email. 2. Quality Guarantee: All products are strictly tested by our QC, confirmed by QA, and approved by a third-party lab in China, USA,

Gabapentin-lactam

Cas:64744-50-9

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

Gabapentin-lactam

Cas:64744-50-9

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

Type:Trading Company

inquiry

Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

Gabapentin-lactam

Cas:64744-50-9

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

Gabapentin-lactam

Cas:64744-50-9

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

Gabapentin-lactam

Cas:64744-50-9

Min.Order:1 Metric Ton

FOB Price: $1.5

Type:Trading Company

inquiry

Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

3,3'-Pentamethylene-4-butyrolactam

Cas:64744-50-9

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD

CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD. founded in 1984, engages in pharmaceutical research, development, production, process design and technical consultation of synthetic and fermentation pharmaceutical products. The organizational s

3,3-pentamethylene-4-butyrolactam(cdi) 64744-50-9 manufacturer/high quality/in stock

Cas:64744-50-9

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

[1-(2-amino-2-oxoethyl)cyclohexyl]acetic acid
99189-60-3

[1-(2-amino-2-oxoethyl)cyclohexyl]acetic acid

gabapentin-lactam
64744-50-9

gabapentin-lactam

Conditions
ConditionsYield
Stage #1: [1-(2-amino-2-oxoethyl)cyclohexyl]acetic acid With sodium hydroxide; sodium hypochlorite In water at 0 - 40℃; for 3.5h;
Stage #2: With hydrogenchloride In water at 100 - 105℃; for 3h; pH=8.2 - 8.8; Product distribution / selectivity; Heating / reflux;
100%
Stage #1: [1-(2-amino-2-oxoethyl)cyclohexyl]acetic acid With sodium hydroxide; sodium hypochlorite In water at 0 - 50℃; for 3h;
Stage #2: With hydrogenchloride In water at 100 - 105℃; for 3h; pH=11 - 12; Product distribution / selectivity;
93.8%
Stage #1: [1-(2-amino-2-oxoethyl)cyclohexyl]acetic acid With sodium hydroxide In water at 20 - 30℃; for 0.5h;
Stage #2: With sode de l'acide trichloroisocyanurique In water at 0 - 20℃; for 5h;
Stage #3: In water; toluene at 80℃; for 8h; Reagent/catalyst;
85%
Multi-step reaction with 2 steps
1.1: trichloroisocyanuric acid / methanol / 1.75 h / 20 - 25 °C
2.1: sodium hydroxide / water / 4 h / 0 - 20 °C
2.2: 8 h / 80 °C
View Scheme
(1-cyanocyclohexyl)-acetic acid
133481-09-1

(1-cyanocyclohexyl)-acetic acid

gabapentin-lactam
64744-50-9

gabapentin-lactam

Conditions
ConditionsYield
Stage #1: (1-cyanocyclohexyl)-acetic acid With sodium hydroxide In water pH=12;
Stage #2: With hydrogen In water; toluene at 80 - 85℃; under 3750.38 - 7500.75 Torr; Inert atmosphere;
97.3%
With chromium-promoted Raney-nickel; hydrogen In water at 110℃; under 15757.7 Torr; for 9h; Reagent/catalyst; Temperature; Autoclave;95.3%
(1-cyanocyclohexyl)acetonitrile
4172-99-0

(1-cyanocyclohexyl)acetonitrile

gabapentin-lactam
64744-50-9

gabapentin-lactam

Conditions
ConditionsYield
Stage #1: (1-cyanocyclohexyl)acetonitrile With sodium hydrogencarbonate at 25℃; for 28h; pH=7.4 - 7.5; Enzymatic reaction;
Stage #2: With sodium hydroxide In water at 20℃;
Stage #3: With hydrogen In water at 80℃; under 7500.75 Torr; Concentration; Time; Inert atmosphere;
93.63%
3-azaspiro[5,5]undecane-2,4-dione
1130-32-1

3-azaspiro[5,5]undecane-2,4-dione

gabapentin-lactam
64744-50-9

gabapentin-lactam

Conditions
ConditionsYield
With methanol; tert-butylhypochlorite; potassium tert-butylate; potassium bromide at 60℃; for 24h; Hofmann type rearrangement; Inert atmosphere;92%
With bromine; sodium hydroxide In water at 0 - 85℃; Product distribution / selectivity;
1-(aminomethyl)cyclohexaneacetic acid potassium salt
955362-91-1

1-(aminomethyl)cyclohexaneacetic acid potassium salt

gabapentin-lactam
64744-50-9

gabapentin-lactam

Conditions
ConditionsYield
With 4-methyl-morpholine; bis(trichloromethyl) carbonate; potassium hydroxide In water; acetonitrile at 20℃; for 0.00277778h; Inert atmosphere;92%
(1-cyanocyclohexyl)acetic acid sodium salt

(1-cyanocyclohexyl)acetic acid sodium salt

gabapentin-lactam
64744-50-9

gabapentin-lactam

Conditions
ConditionsYield
With Raney Nickel In water at 80℃; under 7500.75 Torr; for 18h; pH=13.5;91.9%
ethyl 1-nitromethyl-1-cyclohexaneacetate
133938-45-1

ethyl 1-nitromethyl-1-cyclohexaneacetate

gabapentin-lactam
64744-50-9

gabapentin-lactam

Conditions
ConditionsYield
In palladium-carbon; ethanol91.6%
(+/-)-(5R,6S)-2-(benzoylamino)-4,4,6-trichloro-3-oxo-2-azaspiro[4.5]decane

(+/-)-(5R,6S)-2-(benzoylamino)-4,4,6-trichloro-3-oxo-2-azaspiro[4.5]decane

gabapentin-lactam
64744-50-9

gabapentin-lactam

Conditions
ConditionsYield
With nickel In ethanol at 110℃; for 21h;90%
(1-cyanocyclohexyl)acetic acid barium salt

(1-cyanocyclohexyl)acetic acid barium salt

gabapentin-lactam
64744-50-9

gabapentin-lactam

Conditions
ConditionsYield
With hydrogen In water at 80℃; under 7500.75 Torr; for 20h; pH=13.5;90%
C10H16ClNO3

C10H16ClNO3

gabapentin-lactam
64744-50-9

gabapentin-lactam

Conditions
ConditionsYield
Stage #1: C10H16ClNO3 With sodium hydroxide In water at 0 - 20℃; for 4h;
Stage #2: In toluene at 80℃; for 8h;
90%
2-(4-methoxybenzyl)-2-azaspiro[4.5]decan-3-one
608532-82-7

2-(4-methoxybenzyl)-2-azaspiro[4.5]decan-3-one

gabapentin-lactam
64744-50-9

gabapentin-lactam

Conditions
ConditionsYield
With ammonium cerium(IV) nitrate In water; acetonitrile at 20℃;83%
cyclohexane-diacetic acid-(1.1)-anhydride

cyclohexane-diacetic acid-(1.1)-anhydride

gabapentin-lactam
64744-50-9

gabapentin-lactam

Conditions
ConditionsYield
With ammonia Zersetzen des Ammoniumsalzes mit 1.1 Mol 10%iger Natronlauge, Behandeln des Reaktionsprodukts mit alkal.Kaliumhypobromit-Loesung, zuletzt bei 70-75grad, und Eindampfen mit Salzsaeure;
2-(dimethylamino)-2-azaspiro[4.5]decan-3-one

2-(dimethylamino)-2-azaspiro[4.5]decan-3-one

gabapentin-lactam
64744-50-9

gabapentin-lactam

Conditions
ConditionsYield
With magnesium monoperoxyphthalate hexahydrate In methanol at 20℃; for 3h;39 mg
1-cyclohexene-1-carboxaldehyde
1192-88-7

1-cyclohexene-1-carboxaldehyde

gabapentin-lactam
64744-50-9

gabapentin-lactam

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: CH2Cl2 / 20 °C
2.1: DMAB; methanesulfonic acid / diethyl ether / 3 h / 0 °C
2.2: 81 percent / pyridine / CH2Cl2 / 0 °C
3.1: 77 percent / CuCl; TMEDA / acetonitrile / 20 h / 60 °C
4.1: 90 percent / Raney-Ni / ethanol / 21 h / 110 °C
View Scheme
1-cyclohexen-1-carboxaldehyde benzoylhydrazone

1-cyclohexen-1-carboxaldehyde benzoylhydrazone

gabapentin-lactam
64744-50-9

gabapentin-lactam

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: DMAB; methanesulfonic acid / diethyl ether / 3 h / 0 °C
1.2: 81 percent / pyridine / CH2Cl2 / 0 °C
2.1: 77 percent / CuCl; TMEDA / acetonitrile / 20 h / 60 °C
3.1: 90 percent / Raney-Ni / ethanol / 21 h / 110 °C
View Scheme
N'-(1-cyclohexenylmethyl)-N'-trichloroacetylbenzohydrazide
651311-40-9

N'-(1-cyclohexenylmethyl)-N'-trichloroacetylbenzohydrazide

gabapentin-lactam
64744-50-9

gabapentin-lactam

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 77 percent / CuCl; TMEDA / acetonitrile / 20 h / 60 °C
2: 90 percent / Raney-Ni / ethanol / 21 h / 110 °C
View Scheme
[1-Cyclohexyl-meth-(E)-ylidene]-(4-methoxy-benzyl)-amine
219915-83-0

[1-Cyclohexyl-meth-(E)-ylidene]-(4-methoxy-benzyl)-amine

gabapentin-lactam
64744-50-9

gabapentin-lactam

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: toluene / 1 h / 0 - 20 °C
1.2: 798 mg / triethylamine / toluene / 2 h / 0 - 20 °C
2.1: 26 percent / tributyltin hydride
3.1: 55 percent / triethylsilane; trifluoroacetic acid / CH2Cl2 / 0.5 h / 20 °C
4.1: 83 percent / cerium(IV) ammonium nitrate / acetonitrile; H2O / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: toluene / 1 h / 0 - 20 °C
1.2: 798 mg / triethylamine / toluene / 2 h / 0 - 20 °C
2.1: 2,2'-bipyridine; copper(I) chloride / toluene / 11 h / Heating
3.1: 68 mg / AIBN; tributyltin hydride; water / toluene / 0.75 h / Heating
4.1: 55 percent / triethylsilane; trifluoroacetic acid / CH2Cl2 / 0.5 h / 20 °C
5.1: 83 percent / cerium(IV) ammonium nitrate / acetonitrile; H2O / 20 °C
View Scheme
cyclohexanecarbaldehyde
2043-61-0

cyclohexanecarbaldehyde

gabapentin-lactam
64744-50-9

gabapentin-lactam

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: toluene / Heating
2.1: toluene / 1 h / 0 - 20 °C
2.2: 798 mg / triethylamine / toluene / 2 h / 0 - 20 °C
3.1: 26 percent / tributyltin hydride
4.1: 55 percent / triethylsilane; trifluoroacetic acid / CH2Cl2 / 0.5 h / 20 °C
5.1: 83 percent / cerium(IV) ammonium nitrate / acetonitrile; H2O / 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: toluene / Heating
2.1: toluene / 1 h / 0 - 20 °C
2.2: 798 mg / triethylamine / toluene / 2 h / 0 - 20 °C
3.1: 2,2'-bipyridine; copper(I) chloride / toluene / 11 h / Heating
4.1: 68 mg / AIBN; tributyltin hydride; water / toluene / 0.75 h / Heating
5.1: 55 percent / triethylsilane; trifluoroacetic acid / CH2Cl2 / 0.5 h / 20 °C
6.1: 83 percent / cerium(IV) ammonium nitrate / acetonitrile; H2O / 20 °C
View Scheme
4,4,6-trichloro-2-(dimethylamino)-2-azaspiro[4.5]decan-3-one
608532-87-2

4,4,6-trichloro-2-(dimethylamino)-2-azaspiro[4.5]decan-3-one

gabapentin-lactam
64744-50-9

gabapentin-lactam

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Raney nickel; water / ethanol / 110 °C
2: 39 mg / magnesium monoperoxyphthalate hexahydrate / methanol / 3 h / 20 °C
View Scheme
1-hydroxy-2-(4-methoxybenzyl)-2-azaspiro[4.5]decan-3-one
608532-81-6

1-hydroxy-2-(4-methoxybenzyl)-2-azaspiro[4.5]decan-3-one

gabapentin-lactam
64744-50-9

gabapentin-lactam

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 55 percent / triethylsilane; trifluoroacetic acid / CH2Cl2 / 0.5 h / 20 °C
2: 83 percent / cerium(IV) ammonium nitrate / acetonitrile; H2O / 20 °C
View Scheme
2,2,2-trichloro-N-(cyclohexylidenemethyl)-N-(4-methoxybenzyl)acetamide
608532-79-2

2,2,2-trichloro-N-(cyclohexylidenemethyl)-N-(4-methoxybenzyl)acetamide

gabapentin-lactam
64744-50-9

gabapentin-lactam

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 26 percent / tributyltin hydride
2: 55 percent / triethylsilane; trifluoroacetic acid / CH2Cl2 / 0.5 h / 20 °C
3: 83 percent / cerium(IV) ammonium nitrate / acetonitrile; H2O / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: 2,2'-bipyridine; copper(I) chloride / toluene / 11 h / Heating
2: 68 mg / AIBN; tributyltin hydride; water / toluene / 0.75 h / Heating
3: 55 percent / triethylsilane; trifluoroacetic acid / CH2Cl2 / 0.5 h / 20 °C
4: 83 percent / cerium(IV) ammonium nitrate / acetonitrile; H2O / 20 °C
View Scheme
1,4,4-trichloro-2-(4-methoxybenzyl)-2-azaspiro[4.5]decan-3-one
608532-80-5

1,4,4-trichloro-2-(4-methoxybenzyl)-2-azaspiro[4.5]decan-3-one

gabapentin-lactam
64744-50-9

gabapentin-lactam

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 68 mg / AIBN; tributyltin hydride; water / toluene / 0.75 h / Heating
2: 55 percent / triethylsilane; trifluoroacetic acid / CH2Cl2 / 0.5 h / 20 °C
3: 83 percent / cerium(IV) ammonium nitrate / acetonitrile; H2O / 20 °C
View Scheme
1-(aminomethyl)cyclohexaneacetic acid hydrochloride

1-(aminomethyl)cyclohexaneacetic acid hydrochloride

A

mother liquor A

mother liquor A

B

mother liquor B

mother liquor B

C

gabapentin-lactam
64744-50-9

gabapentin-lactam

D

impurity

impurity

E

H-Gpn-OH
60142-96-3

H-Gpn-OH

Conditions
ConditionsYield
With sodium hydroxide; pyrographite In water at 5 - 75℃; for 8h; Conversion of starting material;
1-(aminomethyl)cyclohexaneacetic acid hydrochloride

1-(aminomethyl)cyclohexaneacetic acid hydrochloride

A

mother liquor B

mother liquor B

B

gabapentin-lactam
64744-50-9

gabapentin-lactam

C

impurity

impurity

D

H-Gpn-OH
60142-96-3

H-Gpn-OH

Conditions
ConditionsYield
With sodium hydroxide; pyrographite In water at 0 - 70℃; for 6h; Conversion of starting material;
With sodium hydroxide; pyrographite In water at 10 - 80℃; for 11.5h; Conversion of starting material;
With sodium hydroxide; pyrographite In water at 5 - 75℃; for 11.5h; Conversion of starting material;
mother liquor A

mother liquor A

mother liquor B

mother liquor B

gabapentin-lactam
64744-50-9

gabapentin-lactam

Conditions
ConditionsYield
With sodium hydroxide; pyrographite In water at 80 - 85℃; for 2h;
ethyl 2-(1-formylcyclohexyl)acetate
460711-33-5

ethyl 2-(1-formylcyclohexyl)acetate

gabapentin-lactam
64744-50-9

gabapentin-lactam

Conditions
ConditionsYield
Stage #1: ethyl 2-(1-formylcyclohexyl)acetate With ammonia In ethanol at 20℃; for 48h;
Stage #2: With hydrogen; acetic acid; 5%-palladium/activated carbon at 80 - 100℃; under 2844.39 Torr; for 3h; Product distribution / selectivity;
gabapentin-lactam
64744-50-9

gabapentin-lactam

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

3-oxo-2-aza-spiro[4.5]decane-2-carboxylic acid tert-butyl ester
898552-75-5

3-oxo-2-aza-spiro[4.5]decane-2-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With dmap In acetonitrile at 25℃;92%
3-phenyl-propionaldehyde
104-53-0

3-phenyl-propionaldehyde

gabapentin-lactam
64744-50-9

gabapentin-lactam

2-(3-phenylprop-1-en-1-yl)-2-azaspiro[4.5]decan-3-one

2-(3-phenylprop-1-en-1-yl)-2-azaspiro[4.5]decan-3-one

Conditions
ConditionsYield
With acetic acid In toluene at 110℃; for 12h; Dean-Stark;92%
gabapentin-lactam
64744-50-9

gabapentin-lactam

1-(aminomethyl)cyclohexaneacetic acid hydrochloride

1-(aminomethyl)cyclohexaneacetic acid hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In water at 80 - 90℃; for 5h; Heating / reflux;90.9%
With hydrogenchloride; water for 24h; Reflux;90%
With hydrogenchloride; water at 100℃; for 10h;90%
gabapentin-lactam
64744-50-9

gabapentin-lactam

diisopropyl hydrogenphosphonate
1809-20-7

diisopropyl hydrogenphosphonate

diisopropyl(3-oxo-2-azaspiro[4,5]decan-2-yl)phosphonate
1417780-49-4

diisopropyl(3-oxo-2-azaspiro[4,5]decan-2-yl)phosphonate

Conditions
ConditionsYield
With copper diacetate; potassium carbonate In toluene at 80℃; under 760.051 Torr; for 0.666667h; Reagent/catalyst; Molecular sieve;87%
gabapentin-lactam
64744-50-9

gabapentin-lactam

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

2-tosyl-2-azaspiro[4.5]decan-3-one

2-tosyl-2-azaspiro[4.5]decan-3-one

Conditions
ConditionsYield
Stage #1: gabapentin-lactam With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere;
Stage #2: p-toluenesulfonyl chloride In tetrahydrofuran; hexane at -78 - 20℃; Inert atmosphere;
87%
gabapentin-lactam
64744-50-9

gabapentin-lactam

benzyl alcohol
100-51-6

benzyl alcohol

2-benzoyl-2-aza-spiro[4.5]decan-3-one

2-benzoyl-2-aza-spiro[4.5]decan-3-one

Conditions
ConditionsYield
With N,N,N,N,-tetramethylethylenediamine; 9-azanoradamantane N-oxyl; oxygen; copper(l) chloride In tetrahydrofuran at 23℃; for 1h; Molecular sieve;87%
gabapentin-lactam
64744-50-9

gabapentin-lactam

para-thiocresol
106-45-6

para-thiocresol

4,4-pentamethylene-N-(p-tolylthio)-2-pyrrolidone

4,4-pentamethylene-N-(p-tolylthio)-2-pyrrolidone

Conditions
ConditionsYield
With potassium fluoride; oxygen In 1,3,5-trimethyl-benzene at 100℃; under 760.051 Torr; for 1h; Autoclave;76%
gabapentin-lactam
64744-50-9

gabapentin-lactam

toluene-4-sulfonamide
70-55-3

toluene-4-sulfonamide

4-methyl-N-(2-azaspiro[4.5]decan-3-ylidene)benzenesulfonamide

4-methyl-N-(2-azaspiro[4.5]decan-3-ylidene)benzenesulfonamide

Conditions
ConditionsYield
With diazoacetic acid ethyl ester; manganese(II) perchlorate hexahydrate In cyclohexane at 90℃; for 12h; chemoselective reaction;72%
gabapentin-lactam
64744-50-9

gabapentin-lactam

Boc-Glu(OBzl)-OH
13574-13-5

Boc-Glu(OBzl)-OH

benzyl (S)-4-((tert-butoxycarbonyl)amino)-5-oxo-5-(3-oxo-2-azaspiro[4.5]decan-2-yl)pentanoate

benzyl (S)-4-((tert-butoxycarbonyl)amino)-5-oxo-5-(3-oxo-2-azaspiro[4.5]decan-2-yl)pentanoate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 0 - 20℃; for 5h;60%
gabapentin-lactam
64744-50-9

gabapentin-lactam

1-aminomethyl-1-cyclohexaneacetic acid hydrobromide
797762-15-3

1-aminomethyl-1-cyclohexaneacetic acid hydrobromide

Conditions
ConditionsYield
With water; hydrogen bromide at 0 - 114℃; for 6 - 24h; Product distribution / selectivity; Heating / reflux;59.27%
With water; hydrogen bromide at 0 - 114℃; for 24 - 45h; Product distribution / selectivity; Heating / reflux;59.27%
BOC-glycine
4530-20-5

BOC-glycine

gabapentin-lactam
64744-50-9

gabapentin-lactam

tert-butyl (2-oxo-2-(3-oxo-2-azaspiro[4.5]decan-2-yl)ethyl)carbamate

tert-butyl (2-oxo-2-(3-oxo-2-azaspiro[4.5]decan-2-yl)ethyl)carbamate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 0 - 20℃; for 5h;57%
gabapentin-lactam
64744-50-9

gabapentin-lactam

iodobenzene
591-50-4

iodobenzene

2-phenyl-2-azaspiro[4.5]decan-3-one

2-phenyl-2-azaspiro[4.5]decan-3-one

Conditions
ConditionsYield
With copper(l) iodide; potassium carbonate; 1,3-bis(methylamino)propane In 1,4-dioxane for 24h; Reflux;50%

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