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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 4-Bromo-2-Methylbenzoic Acid supplier in China

Cas:68837-59-2

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Jinan Finer Chemical Co., Ltd

Product description: Product name 4-Bromo-2-methylbenzoic acid CAS number 68837-59-2 Assay ≥99% Appearance Off-white powder Capacity 200mt/year Application Organic intermedia

4-Bromo-2-methylbenzoic acid

Cas:68837-59-2

Min.Order:10 Gram

FOB Price: $12.0

Type:Lab/Research institutions

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Wuhan Fortuna Chemical Co.,Ltd

Unique advantages of 4-Bromo-2-methylbenzoic acid Cas 68837-59-2 Guaranteed purity High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White to yellowish powder Storage:Cool dry place Package:1kg

Henan Allgreen Chemical Co.,Ltd

high quality Appearance:Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Intermediates Transportation:by air or by sea Port:shanghai

4-Bromo-2-methylbenzoic acid

Cas:68837-59-2

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-Bromo-2-Methylbenzoic Acid

Cas:68837-59-2

Min.Order:1

Negotiable

Type:Other

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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem’s R&D center offer custom synthesis according to the contract research and development services for t

High purity 4-Bromo-2-methylbenzoic acid 98% TOP1 supplier in China

Cas:68837-59-2

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-Bromo-o-toluic acid (COOH=1)

Cas:68837-59-2

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

4-Bromo-2-methylbenzoic acid Basic information Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relat

4-Bromo-2-methylbenzoic acid 68837-59-2

Cas:68837-59-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

4-Bromo-2-methylbenzoic acid)

Cas:68837-59-2

Min.Order:1 Kilogram

FOB Price: $100.0 / 150.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 68837-59-2 with competitive price

Cas:68837-59-2

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

4-Bromo-2-methylbenzoic acid/ LIDE PHARMA- Factory supply / Best price

Cas:68837-59-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Benzoicacid, 4-bromo-2-methyl- 68837-59-2

Cas:68837-59-2

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:68837-59-2

Cas:68837-59-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

4-Bromo-2-Methylbenzoic Acid

Cas:68837-59-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

4-Bromo-2-methylbenzoic acid

Cas:68837-59-2

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

4-bromo-2-methylbenzoic acid

Cas:68837-59-2

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Benzoicacid, 4-bromo-2-methyl-

Cas:68837-59-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Siwei Development Group Ltd.

Product name: 4-Bromo-2-Methylbenzoic Acid CAS No.:68837-59-2 Molecule Formula:C8H7BrO2 Molecule Weight:215.04 Purity: 98.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TES

High Quality 4-Bromo-2-Methylbenzoic Acid on stock

Cas:68837-59-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Shanghai Minstar Chemical Co., Ltd

Product Name: 4-Bromo-2-methylbenzoic acid Synonyms: RARECHEM AL BO 0455;2-METHYL-4-BROMOBENZOIC ACID;4-BROMO-2-METHYLBENZOIC ACID;4-Bromo-o-toluic acid;4-Bromo-2-methylbenzoic acid, 98+%;4-Bromo-2-Methylbenzoic Acid 2-Methyl-4-Bromobenzoic Aci

4-Bromo-2-methylbenzoic acid

Cas:68837-59-2

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

4-Bromo-2-methylbenzoic acid

Cas:68837-59-2

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

inquiry

Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

4-bromo-2-methylbenzoic Acid

Cas:68837-59-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

4-Bromo-2-methylbenzoic acid

Cas:68837-59-2

Min.Order:1 Kilogram

Negotiable

Type:Other

inquiry

HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white crystalline powder Storage:stored in a cool, dry and ventilated place to provent sun and rain Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical

4-Bromo-2-methylbenzoic acid

Cas:68837-59-2

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

inquiry

Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

4-Bromo-2-Methylbenzoic Acid cas no. 68837-59-2 98%

Cas:68837-59-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

4-Bromo-2-methylbenzoic acid

Cas:68837-59-2

Min.Order:0

Negotiable

Type:Other

inquiry

Lonwin Chemical Group Limited

Shanghai Lonwin Chemical company is a subsidiary of Lonwin Industry Group Limited, was established in 2011 and is headquartered in Shanghai, adjacent to China National Convention and Exhibition Center and Hongqiao transportation hub.Lonwinchem is

High Purity 4-Bromo-2-Methylbenzoic Acid 68837-59-2

Cas:68837-59-2

Min.Order:100 Kilogram

FOB Price: $100.0 / 150.0

Type:Other

inquiry

GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

4-Bromo-2-methylbenzoic acid

Cas:68837-59-2

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

4-Bromo-2-Methylbenzoic Acid

Cas:68837-59-2

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

DB BIOTECH CO., LTD

Q1: Are you a manufacturer Answer: Yes, we are factory founded on 2012.Q2: How to contact with us Click "contact supplier" And then send us message the product you interest in, you will get reply within 12 hours.Q3:Which kind of payment terms do you

4-Bromo-2-methylbenzoic acid

Cas:68837-59-2

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

4-Bromo-2-Methylbenzoic Acid

Cas:68837-59-2

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Synthetic route

4-bromo-2-methylbenzonitrile
67832-11-5

4-bromo-2-methylbenzonitrile

4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

Conditions
ConditionsYield
With potassium hydroxide In water Reflux;60%
With sulfuric acid; water
With sodium hydroxide
With sulfuric acid; acetic acid In water for 4.5h; Reflux;
4-methyl-4-tribromomethylcyclohexa-2,5-dien-1-one
10087-24-8

4-methyl-4-tribromomethylcyclohexa-2,5-dien-1-one

4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

Conditions
ConditionsYield
With phosphorus pentabromide
n-butyllithium
109-72-8, 29786-93-4

n-butyllithium

1,4-dibromo-2-methylbenzene
615-59-8

1,4-dibromo-2-methylbenzene

petroleum ether

petroleum ether

A

4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

B

4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

Conditions
ConditionsYield
at 20℃; anschliessend Behandlung mit CO2;
4-bromo-o-xylene
583-71-1

4-bromo-o-xylene

nitric acid
7697-37-2

nitric acid

4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

diazotized 4-amino-2-methyl-benzoic acid

diazotized 4-amino-2-methyl-benzoic acid

4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

Conditions
ConditionsYield
With hydrogen bromide; copper(I) bromide
4-Bromobenzoic acid
586-76-5

4-Bromobenzoic acid

2,2,6,6-tetramethylpiperidinyl-lithium
38227-87-1

2,2,6,6-tetramethylpiperidinyl-lithium

methyl iodide
74-88-4

methyl iodide

A

4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

B

4-bromo-2-ethylbenzoic acid
644984-78-1

4-bromo-2-ethylbenzoic acid

C

3-(2,2,6,6-tetramethylpiperidino)benzoic acid

3-(2,2,6,6-tetramethylpiperidino)benzoic acid

D

4-(2,2,6,6-tetramethylpiperidino)benzoic acid

4-(2,2,6,6-tetramethylpiperidino)benzoic acid

Conditions
ConditionsYield
Stage #1: 4-Bromobenzoic acid; 2,2,6,6-tetramethylpiperidinyl-lithium In tetrahydrofuran; hexane at -78℃; for 4h;
Stage #2: methyl iodide In tetrahydrofuran; hexane at -78 - 20℃;
A 12 % Spectr.
B 22 % Spectr.
C 15 % Spectr.
D 12 % Spectr.
4-Bromo-2-methylaniline
583-75-5

4-Bromo-2-methylaniline

4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: durch Austausch von NH2 gegen CN
2: alcoholic NaOH-solution
View Scheme
p-cresol
106-44-5

p-cresol

n-C3H7X

n-C3H7X

4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: AlBr3 / CS2
2: PBr5
View Scheme
methanol
67-56-1

methanol

4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

4-bromo-2-methyl-benzoic acid methyl ester
99548-55-7

4-bromo-2-methyl-benzoic acid methyl ester

Conditions
ConditionsYield
With hydrogenchloride for 6h; Heating / reflux;100%
With thionyl chloride at 70℃; for 6h;100%
With thionyl chloride at 0℃; Inert atmosphere; Reflux;100%
4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

4-bromo-2-methylbenzoyl chloride
21900-45-8

4-bromo-2-methylbenzoyl chloride

Conditions
ConditionsYield
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 9h;100%
With thionyl chloride In toluene for 15h; Reflux;92%
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane for 0.5h; Cooling with ice;89%
4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

4-bromo-2-methylbenzyl alcohol
17100-58-2

4-bromo-2-methylbenzyl alcohol

Conditions
ConditionsYield
With borane-THF In tetrahydrofuran at 0 - 20℃; for 1h;100%
Stage #1: 4-bromo-2-methylbenzoic acid With borane-THF In tetrahydrofuran at 0 - 20℃; for 3h;
Stage #2: With water; sodium hydrogencarbonate In tetrahydrofuran
100%
With borane-THF In tetrahydrofuran at 0 - 20℃; for 2h;100%
4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

diazomethyl-trimethyl-silane
18107-18-1

diazomethyl-trimethyl-silane

4-bromo-2-methyl-benzoic acid methyl ester
99548-55-7

4-bromo-2-methyl-benzoic acid methyl ester

Conditions
ConditionsYield
In dichloromethane100%
In tetrahydrofuran; methanol; hexanes at 0 - 20℃; for 1h;100%
In tetrahydrofuran; methanol at 0 - 20℃; for 1h;92%
4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

methyl iodide
74-88-4

methyl iodide

4-bromo-2-methyl-benzoic acid methyl ester
99548-55-7

4-bromo-2-methyl-benzoic acid methyl ester

Conditions
ConditionsYield
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 80℃;100%
With potassium carbonate In N,N-dimethyl-formamide at 20℃;100%
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 80℃;100%
4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

4-bromo-2-methyl-benzoic acid methyl ester
99548-55-7

4-bromo-2-methyl-benzoic acid methyl ester

Conditions
ConditionsYield
With hydrogenchloride In methanol100%
With hydrogenchloride In methanol100%
With methanol; hydrogenchloride for 3h; Heating / reflux;86%
4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

4-bromo-2-methylbenzamide

4-bromo-2-methylbenzamide

Conditions
ConditionsYield
Stage #1: 4-bromo-2-methylbenzoic acid With oxalyl dichloride In dichloromethane at 0 - 20℃; for 2h;
Stage #2: With ammonium hydroxide In dichloromethane at 0 - 25℃; for 1h;
100%
With ammonium hydroxide; oxalyl dichloride In dichloromethane100%
Stage #1: 4-bromo-2-methylbenzoic acid With oxalyl dichloride In dichloromethane at 0 - 20℃; for 2h;
Stage #2: With ammonium hydroxide In dichloromethane at 0 - 25℃; for 1h;
100%
Stage #1: 4-bromo-2-methylbenzoic acid With thionyl chloride In dichloromethane for 1h;
Stage #2: With ammonium hydroxide
95%
With 4-methyl-morpholine
4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

Cyclopropylamine
765-30-0

Cyclopropylamine

4-bromo-N-cyclopropyl-2-methylbenzamide
345965-99-3

4-bromo-N-cyclopropyl-2-methylbenzamide

Conditions
ConditionsYield
Stage #1: 4-bromo-2-methylbenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 16h;
Stage #2: Cyclopropylamine With triethylamine In dichloromethane at 0 - 20℃; for 2.25h;
99%
Stage #1: 4-bromo-2-methylbenzoic acid With thionyl chloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 16h;
Stage #2: Cyclopropylamine With triethylamine In dichloromethane at 20℃; for 2h;
99%
Stage #1: 4-bromo-2-methylbenzoic acid; Cyclopropylamine With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;
Stage #2: With sodium hydroxide In water at 20℃;
87%
4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

N,N-dimethylammonium chloride
506-59-2

N,N-dimethylammonium chloride

4-bromo-2-methyl-N,N-dimethylbenzamide
862470-12-0

4-bromo-2-methyl-N,N-dimethylbenzamide

Conditions
ConditionsYield
Stage #1: 4-bromo-2-methylbenzoic acid With thionyl chloride at 60℃; for 3h;
Stage #2: N,N-dimethylammonium chloride With triethylamine In dichloromethane at 0 - 20℃; for 2h;
99%
Stage #1: 4-bromo-2-methylbenzoic acid With thionyl chloride at 60℃; for 3h;
Stage #2: N,N-dimethylammonium chloride With triethylamine In dichloromethane at 0 - 20℃; for 2h;
99%
Stage #1: 4-bromo-2-methylbenzoic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran at 20℃; for 0.0833333h;
Stage #2: N,N-dimethylammonium chloride With triethylamine In tetrahydrofuran at 20℃; for 3h;
pyrrolidine
123-75-1

pyrrolidine

4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate
125700-67-6

O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

N-ethyl-N,N-diisopropylamine
7087-68-5

N-ethyl-N,N-diisopropylamine

(4-bromo-2-methylphenyl)(pyrrolidin-1-yl)methanone
276678-35-4

(4-bromo-2-methylphenyl)(pyrrolidin-1-yl)methanone

Conditions
ConditionsYield
In tetrahydrofuran; water98%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

4-bromo-2-methyl-benzoic acid tert-butyl ester
445003-37-2

4-bromo-2-methyl-benzoic acid tert-butyl ester

Conditions
ConditionsYield
With dmap In tert-butyl alcohol at 20℃; for 18h;98%
With dmap In tert-butyl alcohol at 20℃; for 18h;98%
With dmap In tert-butyl alcohol at 20℃; for 12h;96%
4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

4-bromo-5-iodo-2-methylbenzoic acid
1022983-51-2

4-bromo-5-iodo-2-methylbenzoic acid

Conditions
ConditionsYield
With N-iodo-succinimide; sulfuric acid at 0 - 5℃; for 1h;98%
With N-iodo-succinimide; sulfuric acid at 0℃;75%
acrylic acid n-butyl ester
141-32-2

acrylic acid n-butyl ester

4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

n-butyl 2-(6-bromo-4-methyl-3-oxo-1,3-dihydroisobenzofuran-1-yl)acetate

n-butyl 2-(6-bromo-4-methyl-3-oxo-1,3-dihydroisobenzofuran-1-yl)acetate

Conditions
ConditionsYield
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; oxygen; cesium acetate In methanol at 60℃; under 760.051 Torr; for 18h; Schlenk technique; chemoselective reaction;98%
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; copper(II) acetate monohydrate In water at 80℃; for 16h; Inert atmosphere; Sealed tube; Green chemistry;89%
3-Pyrroline
109-96-6

3-Pyrroline

4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

4-(2,5-dihydro-pyrrol-1-yl-carbonyl)-3-methyl-bromobenzene
651045-03-3

4-(2,5-dihydro-pyrrol-1-yl-carbonyl)-3-methyl-bromobenzene

Conditions
ConditionsYield
With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate In N,N-dimethyl-formamide at 20℃; for 16h;97%
With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate In N,N-dimethyl-formamide at 20℃; for 16h;97%
4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

ethyl iodide
75-03-6

ethyl iodide

ethyl 4-bromo-2-methylbenzoate
220389-34-4

ethyl 4-bromo-2-methylbenzoate

Conditions
ConditionsYield
With sodium carbonate In N,N-dimethyl-formamide at 60℃; for 16h;97%
ethanol
64-17-5

ethanol

4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

ethyl 4-bromo-2-methylbenzoate
220389-34-4

ethyl 4-bromo-2-methylbenzoate

Conditions
ConditionsYield
With thionyl chloride for 3h; Reflux;96%
With sulfuric acid at 120℃; for 0.0833333h; Microwave irradiation;79%
With sulfuric acid for 72h; Heating / reflux;
With sulfuric acid for 18h; Heating / reflux;
With hydrogenchloride at 45℃; for 8h;
4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

tert-butyl alcohol
75-65-0

tert-butyl alcohol

4-bromo-2-methyl-benzoic acid tert-butyl ester
445003-37-2

4-bromo-2-methyl-benzoic acid tert-butyl ester

Conditions
ConditionsYield
With dmap; di-tert-butyl dicarbonate at 20℃; for 12h;96%
4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

isopropyl alcohol
67-63-0

isopropyl alcohol

isopropyl 2-methyl-4-bromobenzoate
345965-04-0

isopropyl 2-methyl-4-bromobenzoate

Conditions
ConditionsYield
With sulfuric acid In benzene for 96h; Heating / reflux;95%
With sulfuric acid for 96h; Heating / reflux;95%
79%
79%
-butyl vinyl ether
111-34-2

-butyl vinyl ether

4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

4-acetyl-2-methyl benzoic acid
55860-35-0

4-acetyl-2-methyl benzoic acid

Conditions
ConditionsYield
Stage #1: -butyl vinyl ether; 4-bromo-2-methylbenzoic acid With 1,3-bis-(diphenylphosphino)propane; potassium carbonate; palladium diacetate In water; butan-1-ol for 5h; Inert atmosphere; Reflux;
Stage #2: With hydrogenchloride In water; toluene
95%
aminomethylphosphonic acid diethyl ester
50917-72-1

aminomethylphosphonic acid diethyl ester

4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

diethyl ((4-bromo-2-methylbenzamido)methyl)phosphonate

diethyl ((4-bromo-2-methylbenzamido)methyl)phosphonate

Conditions
ConditionsYield
With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 18h;95%
4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

diethyl (aminomethyl)phosphonate oxalate

diethyl (aminomethyl)phosphonate oxalate

diethyl ((4-bromo-2-methylbenzamido)methyl)phosphonate

diethyl ((4-bromo-2-methylbenzamido)methyl)phosphonate

Conditions
ConditionsYield
With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In methanol; N,N-dimethyl-formamide at 20℃; for 18h;95%
4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

ethyl 4-bromo-2-methylbenzoate
220389-34-4

ethyl 4-bromo-2-methylbenzoate

Conditions
ConditionsYield
With concentrated sulfuric acid In ethanol93%
methanol
67-56-1

methanol

4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

ethyl 4-bromo-2-methylbenzoate
220389-34-4

ethyl 4-bromo-2-methylbenzoate

Conditions
ConditionsYield
With sulfuric acid at 100℃; Inert atmosphere;92%
4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

2-fluoro-5-methoxyphenylboronic acid

2-fluoro-5-methoxyphenylboronic acid

2′-fluoro-5′-methoxy-3-methylbiphenyl-4-carboxylic acid
1610370-14-3

2′-fluoro-5′-methoxy-3-methylbiphenyl-4-carboxylic acid

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); tetrabutylammomium bromide; sodium carbonate In water at 130℃; for 0.333333h; Sealed tube; Microwave irradiation;92%
With tetrakis(triphenylphosphine) palladium(0); tetrabutylammomium bromide; sodium carbonate In water at 130℃; for 0.333333h; Microwave irradiation; Sealed tube;92%
With tetrakis(triphenylphosphine) palladium(0); tetrabutylammomium bromide; sodium carbonate at 130℃; for 0.333333h; Sealed tube; Microwave irradiation;92%
4-aminotetrahydropyran
38041-19-9

4-aminotetrahydropyran

4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

4-bromo-2-methyl-N-(tetrahydropyran-4-yl)benzamide
1350411-41-4

4-bromo-2-methyl-N-(tetrahydropyran-4-yl)benzamide

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 20℃; for 16h; Cooling with ice;92%
4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

4-bromo-N-methoxy-N,2-dimethylbenzamide
178313-45-6

4-bromo-N-methoxy-N,2-dimethylbenzamide

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;91.6%
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h;79%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃;74%
tributyl borane
122-56-5

tributyl borane

4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

4-butyl-2-methylbenzoic acid

4-butyl-2-methylbenzoic acid

Conditions
ConditionsYield
In tetrahydrofuran Suzuki-Miyaura Coupling; Inert atmosphere;90%
4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

4-methoxyphenylboronic acid
5720-07-0

4-methoxyphenylboronic acid

4'-methoxy-3-methyl-4-cyanodiphenyl
104582-73-2

4'-methoxy-3-methyl-4-cyanodiphenyl

Conditions
ConditionsYield
Stage #1: 4-bromo-2-methylbenzoic acid With resin-bound amine; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate In N,N-dimethyl-formamide at 20℃; for 18h;
Stage #2: 4-methoxyphenylboronic acid With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In 1,2-dimethoxyethane for 48h; Suzuki coupling; Heating;
Stage #3: With pyridine; trifluoroacetic anhydride In dichloromethane at 20℃; for 16h;
89%
zinc(II) cyanide
557-21-1

zinc(II) cyanide

4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

4-cyano-2-methylbenzoic acid methyl ester
103261-67-2

4-cyano-2-methylbenzoic acid methyl ester

Conditions
ConditionsYield
tetrakis(triphenylphosphine) palladium(0) In N,N-dimethyl-formamide at 100℃; for 16h; Inert atmosphere;89%

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