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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

4-Bromo-3-methylbenzoic acid Manufacturer/High quality/Best price/In stock

Cas:7697-28-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Simagchem Corporation

Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

High quality 3-Methyl-4-Bromobenzoic Acid supplier in China

Cas:7697-28-1

Min.Order:1 Metric Ton

Negotiable

Type:Manufacturers

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Henan Allgreen Chemical Co.,Ltd

high quality Appearance:Solid Storage:Sealed, dry, microtherm , avoid light and smell. Package:According to the demand of customer Application:Intermediates Transportation:by air or by sea Port:shanghai

4-Bromo-3-methylbenzoic acid

Cas:7697-28-1

Min.Order:1 Kilogram

Negotiable

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

4-Bromo-m-toluic acid (COOH=1)

Cas:7697-28-1

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

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Henan Tianfu Chemical Co., Ltd.

High purity CAS 7697-28-1 4-Bromo-3-methylbenzoic acid in stock Our main business covers the fields below: 1.Noble Metal Catalysts (Pt.Pd...) 2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...) 3.OLED intermediate

High purity CAS 7697-28-1 4-Bromo-3-methylbenzoic acid in stock

Cas:7697-28-1

Min.Order:1 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

4-Bromo-3-methylbenzoic acid

Cas:7697-28-1

Min.Order:1 Kilogram

FOB Price: $2.0 / 10.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 7697-28-1 with competitive price

Cas:7697-28-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

4-Bromo-3-methylbenzoic acid

Cas:7697-28-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

CAS NO.:7697-28-1

Cas:7697-28-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Xiamen Hisunny Chemical Co.,Ltd

Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

3-Methyl-4-Bromobenzoic Acid

Cas:7697-28-1

Min.Order:0

Negotiable

Type:Manufacturers

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Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

4-Bromo-3-methylbenzoic acid CAS 7697-28-1

Cas:7697-28-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4-Bromo-3-methylbenzoic acid

Cas:7697-28-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Ality Chemical Corporation

The above product is Ality Chemical's strong item with best price, good quality and fast supply. Ality Chemical has been focusing on the research and production of this field for over 14 years. At the same time, we are always committed to providi

Factory Supply 4-Bromo-m-toluic acid (COOH=1)

Cas:7697-28-1

Min.Order:0 Metric Ton

Negotiable

Type:Other

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Siwei Development Group Ltd.

Product name: 4-Bromo-3-Methylbenzoic Acid CAS No.:7697-28-1 Molecule Formula:C8H6BrO2 Molecule Weight:214.04 Purity: 98.0% Package: 25kg/drum Description:White powder Manufacture Standards:Enterprise Standard TEST

High Quality 4-Bromo-3-Methylbenzoic Acid on stock

Cas:7697-28-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Zibo Dorne chemical technology co. LTD

Product Details Grade: pharmaceutical grade Purity:99%+ ProductionCapacity: 1000 Kilogram/Month Scope of use: For scientific research only(The product must be used legally) Our Advantage 1. Best quality with competitive price. 2. Quick shipping,

4-Bromo-3-methylbenzoic acid

Cas:7697-28-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Hangzhou Zhongqi chem Co.,Ltd.

Located in Hangzhou National Hi-Tech Industrial Development Zone, zhongqichem is a technical company mainly focus on the Custom synthesis, manufacturing, sales of chemicals to various industries. Benefiting from the outstanding customer service and h

4-Bromo-3-methylbenzoic acid

Cas:7697-28-1

Min.Order:0

Negotiable

Type:Other

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Hunan chemfish Pharmaceutical co.,Ltd

Appearance:95%+ Package:R&D,Pilot run Transportation:per client require Port:Express ,Air, Sea

4-Bromo-3-methylbenzoic acid

Cas:7697-28-1

Min.Order:0

Negotiable

Type:Manufacturers

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Suzhou Health Chemicals Co., Ltd.

High quality,stable supply chain.Appearance:white/off-white or light yellow Storage:Store in cool and dry place, keep away from strong light and heat. Package:aluminum bottle,glass bottle,PTFE bottle,cardboard drum Application:This product can be use

4-bromo-3-methylbenzoic Acid

Cas:7697-28-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Golden Pharma Co., Limited

GOLDEN PHARMA CO.,LIMITED.is a professional pharmaceutical company,our team have more than 20years expereince in pharmaceutical production and sales. we are a professional technical enterprise specializing in the R & D, production,QA regulation

4-bromo-3-methylbenzoic acid

Cas:7697-28-1

Min.Order:1 Kilogram

Negotiable

Type:Other

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HANGZHOU YUNUO CHEMICAL CO.,LTD

Superior quality, moderate price & quick delivery. Appearance:white crystalline powder Storage:stored in a cool, dry and ventilated place to provent sun and rain Package:25kg/drum, or as per your request. Application:Used as Pharmaceutical

4-Bromo-3-methylbenzoic acid

Cas:7697-28-1

Min.Order:1 Kilogram

Negotiable

Type:Trading Company

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Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

4-Bromo-3-Methylbenzoic Acid cas no. 7697-28-1 98%

Cas:7697-28-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

4-Bromo-m-toluic acid (COOH=1)

Cas:7697-28-1

Min.Order:0

Negotiable

Type:Other

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Wuxi TAA Chemical Industry Co.,LTD.

1.A strong technical force and advanced processing equipments. The quality of the products has been strictly inspected and all kinds of index have reached or exceeded domestic and international standards.2. Now we have established long-term stable re

4-Bromo-3-methylbenzoic acid cas 7697-28-1

Cas:7697-28-1

Min.Order:0

Negotiable

Type:Other

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Lonwin Chemical Group Limited

Shanghai Lonwin Chemical company is a subsidiary of Lonwin Industry Group Limited, was established in 2011 and is headquartered in Shanghai, adjacent to China National Convention and Exhibition Center and Hongqiao transportation hub.Lonwinchem is

Best price 3-Methyl-4-Bromobenzoic Acid 7697-28-1

Cas:7697-28-1

Min.Order:100 Kilogram

FOB Price: $100.0 / 150.0

Type:Other

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GIHI CHEMICALS CO.,LIMITED

high purity,in stock Package:25kg/drum,or as per customers'demand Application:API,Pharmaceutical intermediates Transportation:air,sea,courier

4-Bromo-3-methylbenzoic acid

Cas:7697-28-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

JINHUA HUAYI CHEMICAL CO., LTD.

Jinhua huayi chemical co., ltd. is dedicated to the development, production and marketing of chemicals. On the basis of equality and mutual benefit, and under the principle of customer first, credit first, quality first, we are ready to join hands

4-Bromo-3-Methylbenzoic Acid

Cas:7697-28-1

Min.Order:100 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Fortuna Chemical Co.,Ltd

stable supply&competitive price Storage:Available Package:25KG Or as client requirement Application:Important pharm intermediate Transportation:By air or By sea

4-Bromo-3-methylbenzoic acid

Cas:7697-28-1

Min.Order:0

Negotiable

Type:Trading Company

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Shanghai Acmec Biochemical Technology Co., Ltd.

Acmec is a leading manufacturer and supplier of biochemical reagents and life science products. We have over 40,000 items in stock (real-time inventory) and offer discounted prices to registered members of the online store ( www.acmec.com.cn ) Appea

Acmec 4-Bromo-3-methylbenzoic acid 500g

Cas:7697-28-1

Min.Order:1 bottle

Negotiable

Type:Lab/Research institutions

inquiry

Aecochem Corp.

Our clients, like BASF,CHEMO,Brenntag,ASR,Evonik,Merck and etc.Appearance:COA Storage:in stock Application:MSDS/TDS

3-Methyl-4-Bromobenzoic Acid

Cas:7697-28-1

Min.Order:0

Negotiable

Type:Manufacturers

inquiry

Hubei Taiho Chemical Co.,LTD

TAIHO Unique Advantages:1.We're factory2.Free samples available3.Commodity inspection can be done4.ISO9001,Kosher certifications5.10 years experiences Storage:Store in cool &dry place Package:aluminium foil bag/fiber can/plastic drum Application:comp

4-Bromo-3-methylbenzoic acid

Cas:7697-28-1

Min.Order:0

Negotiable

Type:Manufacturers

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Synthetic route

4-amino 3-methylbenzoic acid
2486-70-6

4-amino 3-methylbenzoic acid

4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

Conditions
ConditionsYield
Stage #1: 4-amino 3-methylbenzoic acid With hydrogen bromide In water at 25℃; for 1h;
Stage #2: With sodium nitrate In water at -2 - -1℃; for 1.75h;
Stage #3: With hydrogen bromide; copper(I) bromide In water at -2 - 70℃; for 2h;
90%
Diazotization.Kochen der Diazoverbindung mit Bromwasserstoffsaeure;
With hydrogen bromide; sodium nitrite; copper(I) chloride In water
4,4'-dibromo-5,3'-dimethyl-2-nitrodiphenylmethane
84797-77-3

4,4'-dibromo-5,3'-dimethyl-2-nitrodiphenylmethane

A

4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

B

6-bromo-5-methyl-3-(4'-bromo-3'-methylphenyl)-2,1-isoxazole
93099-47-9

6-bromo-5-methyl-3-(4'-bromo-3'-methylphenyl)-2,1-isoxazole

C

3,6-dibromo-2,7-dimethylacridone
84658-94-6

3,6-dibromo-2,7-dimethylacridone

Conditions
ConditionsYield
With sulfuric acid In ethanol for 5h; Irradiation;A 63%
B 20%
C 6%
With sulfuric acid In ethanol for 5h; Product distribution; Mechanism; Irradiation;A 51%
B 20%
C 6%
4-bromo-3-methyl-N-(2-methyl-4-cyanophenyl)benzamide
146308-26-1

4-bromo-3-methyl-N-(2-methyl-4-cyanophenyl)benzamide

A

4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

B

4-amino-3-methylbenzonitrile
78881-21-7

4-amino-3-methylbenzonitrile

Conditions
ConditionsYield
With potassium hydroxide In ethanol a) 70 deg C, 4.5 h, b) 80 deg C, 3 h; Yields of byproduct given;A 63%
B n/a
With potassium hydroxide In ethanol a) 70 deg C, 4.5 h, b) 80 deg C, 3 h; Yield given;A 63%
B n/a
1-bromo-2,4-dimethylbenzene
583-70-0

1-bromo-2,4-dimethylbenzene

4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

Conditions
ConditionsYield
With nitric acid60%
With nitric acid for 24h; Heating / reflux;60%
With nitric acid at 150℃;
With nitric acid
n-butyllithium
109-72-8, 29786-93-4

n-butyllithium

1,4-dibromo-2-methylbenzene
615-59-8

1,4-dibromo-2-methylbenzene

4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

Conditions
ConditionsYield
With diethyl ether Aufgiessen des Reaktionsgemisches auf festes Kohlendioxid;
1,4-dibromo-2-methylbenzene
615-59-8

1,4-dibromo-2-methylbenzene

A

2-methylterephthalic acid
5156-01-4

2-methylterephthalic acid

B

4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

Conditions
ConditionsYield
With n-butyllithium; Petroleum ether anschliessendes Behandeln mit festem Kohlendioxid;
1-bromo-4-isopropyl-2-methyl-benzene
92243-75-9

1-bromo-4-isopropyl-2-methyl-benzene

4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

Conditions
ConditionsYield
With nitric acid
1-(4-bromo-3-methylphenyl)ethan-1-one
37074-40-1

1-(4-bromo-3-methylphenyl)ethan-1-one

A

4-bromo-isophthalic acid
6939-93-1

4-bromo-isophthalic acid

B

4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

Conditions
ConditionsYield
With potassium permanganate
With alkaline potassium permanganate
m-Toluic acid
99-04-7

m-Toluic acid

A

4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

B

2-bromo-5-methylbenzoic acid
6967-82-4

2-bromo-5-methylbenzoic acid

Conditions
ConditionsYield
With bromine
amino-5-bromo-2-toluene
6933-10-4

amino-5-bromo-2-toluene

copper(I) cyanide
544-92-3

copper(I) cyanide

4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

Conditions
ConditionsYield
(i) NaNO2, aq. HCl, (ii) /BRN= 3587244/, (iii) NaOH, EtOH; Multistep reaction;
bromine
7726-95-6

bromine

m-Toluic acid
99-04-7

m-Toluic acid

A

4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

B

2-bromo-5-methylbenzoic acid
6967-82-4

2-bromo-5-methylbenzoic acid

n-butyllithium
109-72-8, 29786-93-4

n-butyllithium

1,4-dibromo-2-methylbenzene
615-59-8

1,4-dibromo-2-methylbenzene

petroleum ether

petroleum ether

A

4-bromo-2-methylbenzoic acid
68837-59-2

4-bromo-2-methylbenzoic acid

B

4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

Conditions
ConditionsYield
at 20℃; anschliessend Behandlung mit CO2;
1-bromo-2,4-dimethylbenzene
583-70-0

1-bromo-2,4-dimethylbenzene

chromic acid mixture

chromic acid mixture

4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

4-ethyl-1-bromo-2-methyl-benzene
90560-90-0

4-ethyl-1-bromo-2-methyl-benzene

nitric acid
7697-37-2

nitric acid

4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

1-bromo-4-isopropyl-2-methyl-benzene
92243-75-9

1-bromo-4-isopropyl-2-methyl-benzene

nitric acid
7697-37-2

nitric acid

4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

asymm. bromo-m-xylene

asymm. bromo-m-xylene

4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

Conditions
ConditionsYield
With dichromate mixture
1-(4-bromo-3-methylphenyl)ethan-1-one
37074-40-1

1-(4-bromo-3-methylphenyl)ethan-1-one

KMnO4

KMnO4

aqueous KOH

aqueous KOH

4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

4-Bromobenzoic acid
586-76-5

4-Bromobenzoic acid

methyl iodide
74-88-4

methyl iodide

4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

Conditions
ConditionsYield
Stage #1: 4-Bromobenzoic acid With 2,2,6,6-tetramethylpiperidinyl-lithium In tetrahydrofuran; hexane at -78℃; for 4h;
Stage #2: methyl iodide In tetrahydrofuran; hexane at -78 - 20℃;
12 % Spectr.
3-Methylacetanilide
537-92-8

3-Methylacetanilide

4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (i) (bromination), (ii) (hydrolysis)
2: (i) NaNO2, aq. HCl, (ii) /BRN= 3587244/, (iii) NaOH, EtOH
View Scheme
4-Bromo-3-methylbenzoic acid methyl ester
148547-19-7

4-Bromo-3-methylbenzoic acid methyl ester

4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

Conditions
ConditionsYield
Stage #1: 4-Bromo-3-methylbenzoic acid methyl ester With water; sodium hydroxide In tetrahydrofuran at 20℃; for 16h;
Stage #2: With hydrogenchloride In water
4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

4-bromo-3-methylbenzylalcohol
149104-89-2

4-bromo-3-methylbenzylalcohol

Conditions
ConditionsYield
With borane-THF In tetrahydrofuran at 0 - 20℃;100%
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 0.25h;100%
With borane In tetrahydrofuran at -30 - 20℃;98%
4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

phenylboronic acid
98-80-6

phenylboronic acid

2-methyl[1,1'-biphenyl]-4-carboxylic acid
178313-67-2

2-methyl[1,1'-biphenyl]-4-carboxylic acid

Conditions
ConditionsYield
With disodium hydrogenphosphate; disodium bis(2-aminopyrimidine-4,6-diolate)palladium acetate In water at 50 - 120℃; for 0.166667h; Microwave irradiation;100%
With disodium hydrogenphosphate; Pd(OAc)2(2-amino-4,6-dihydroxypyrimidine disodium salt)2 In water at 120℃; for 0.166667h; Suzuki-Miyaura coupling; Microwave irradiation;99%
With potassium fluoride; palladium diacetate; XPhos In tetrahydrofuran for 1h; Heating / reflux;
3-METHOXYBENZYLAMINE
5071-96-5

3-METHOXYBENZYLAMINE

4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

4-bromo-N-(3-methoxybenzyl)-3-methylbenzamide
1623120-19-3

4-bromo-N-(3-methoxybenzyl)-3-methylbenzamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane at 20℃; for 1h; Inert atmosphere;100%
4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

m-tolylboronic acid
17933-03-8

m-tolylboronic acid

3-methyl-4-(m-tolyl)benzoic acid

3-methyl-4-(m-tolyl)benzoic acid

Conditions
ConditionsYield
With disodium hydrogenphosphate; disodium bis(2-aminopyrimidine-4,6-diolate)palladium acetate In water at 50 - 120℃; for 0.166667h; Microwave irradiation;100%
4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

isopropylamine
75-31-0

isopropylamine

4-bromo-N-isopropyl-3-methylbenzamide

4-bromo-N-isopropyl-3-methylbenzamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate at 0 - 20℃; for 1h;100%
4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

2-Methylphenylboronic acid
16419-60-6

2-Methylphenylboronic acid

2,2’-dimethyl-1,1’-biphenyl-4-carboxylic acid
69535-85-9

2,2’-dimethyl-1,1’-biphenyl-4-carboxylic acid

Conditions
ConditionsYield
With disodium hydrogenphosphate; Pd(OAc)2(2-amino-4,6-dihydroxypyrimidine disodium salt)2 In water at 120℃; for 0.166667h; Suzuki-Miyaura coupling; Microwave irradiation;99%
With disodium hydrogenphosphate; disodium bis(2-aminopyrimidine-4,6-diolate)palladium acetate In water at 50 - 120℃; for 0.166667h; Microwave irradiation;95%
3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)aniline
1428155-06-9

3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)aniline

4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

4-bromo-3-methyl-N-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)phenyl)benzamide
1428155-45-6

4-bromo-3-methyl-N-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)phenyl)benzamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane at 0 - 20℃; for 3h; Inert atmosphere;99%
methanol
67-56-1

methanol

4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

4-Bromo-3-methylbenzoic acid methyl ester
148547-19-7

4-Bromo-3-methylbenzoic acid methyl ester

Conditions
ConditionsYield
With sulfuric acid In methanol for 14h; Reflux;97%
With sulfuric acid Reflux;95%
Stage #1: methanol With acetyl chloride for 0.416667h;
Stage #2: 4-bromo-3-methylbenzoic acid for 18h; Heating / reflux;
93%
ethanol
64-17-5

ethanol

4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

ethyl 3-methyl-4-bromobenzoate
160313-69-9

ethyl 3-methyl-4-bromobenzoate

Conditions
ConditionsYield
With thionyl chloride at 83℃; for 6h;96%
With sulfuric acid In toluene for 1h; Heating;80%
With hydrogenchloride
N-trimethylsilylmethylamine
18166-02-4

N-trimethylsilylmethylamine

4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

4-bromo-3-methyl-N-trimethylsilanylmethyl-benzamide
1370257-42-3

4-bromo-3-methyl-N-trimethylsilanylmethyl-benzamide

Conditions
ConditionsYield
Stage #1: 4-bromo-3-methylbenzoic acid With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.5h;
Stage #2: N-trimethylsilylmethylamine In dichloromethane at 20℃; Product distribution / selectivity;
94%
cyclobutylamine
2516-34-9

cyclobutylamine

4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

4-bromo-N-cyclobutyl-3-methylbenzamide

4-bromo-N-cyclobutyl-3-methylbenzamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃;94%
4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

methylamine
74-89-5

methylamine

4-bromo-N,3-dimethylbenzamide

4-bromo-N,3-dimethylbenzamide

Conditions
ConditionsYield
Stage #1: 4-bromo-3-methylbenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 2h;
Stage #2: methylamine In ethanol at 20℃; for 0.5h;
94%
2-(2-Hydroxyethyl)pyridine
103-74-2

2-(2-Hydroxyethyl)pyridine

4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

2-(2-pyridyl)ethyl 4-bromo-3-methylbenzoate
920270-48-0

2-(2-pyridyl)ethyl 4-bromo-3-methylbenzoate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 16h; Inert atmosphere;92%
4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

3-(8-nitroquinolin-4-yl)benzenamine

3-(8-nitroquinolin-4-yl)benzenamine

4-bromo-3-methyl-N-(3-(8-nitroquinolin-4-yl)phenyl)benzamide

4-bromo-3-methyl-N-(3-(8-nitroquinolin-4-yl)phenyl)benzamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 0 - 20℃;92%
4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

4-carboxyphenylboronic acid
14047-29-1

4-carboxyphenylboronic acid

2-methyl-[1,1′-biphenyl]-4,4′-dicarboxylic acid
1186048-28-1

2-methyl-[1,1′-biphenyl]-4,4′-dicarboxylic acid

Conditions
ConditionsYield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; triphenylphosphine In water; N,N-dimethyl-formamide at 90℃; for 24h;91%
With {1,1'-bis(diphenylphosphino)ferrocene} palladium dibromide; sodium carbonate In water; N,N-dimethyl-formamide at 90℃; for 3h; Inert atmosphere;
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In ethanol; water; toluene for 24h; Reflux;
4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

4-phenyl-2,3-dihydro-1H-indole
179473-53-1

4-phenyl-2,3-dihydro-1H-indole

(4-bromo-3-methylphenyl)(4-phenylindolin-1-yl)methanone

(4-bromo-3-methylphenyl)(4-phenylindolin-1-yl)methanone

Conditions
ConditionsYield
Stage #1: 4-bromo-3-methylbenzoic acid; 4-phenyl-2,3-dihydro-1H-indole With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃;
Stage #2: With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 2h;
90.2%
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 3h;87%
4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

bis(pinacol)diborane
73183-34-3

bis(pinacol)diborane

3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid
269409-74-7

3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In N,N-dimethyl-formamide at 120℃; for 0.25h; Microwave irradiation;90%
With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In N,N-dimethyl-formamide at 120℃; for 0.25h; Microwave irradiation;90%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In N,N-dimethyl-formamide at 125℃; for 0.333333h; Microwave irradiation;74%
With triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In 1,4-dioxane at 20 - 80℃;
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

tert-butyl 4-bromo-3-methylbenzoate
347174-28-1

tert-butyl 4-bromo-3-methylbenzoate

Conditions
ConditionsYield
With dmap In tetrahydrofuran Reflux;87%
With dmap In tetrahydrofuran Reflux;87%
With dmap In tetrahydrofuran; tert-butyl alcohol at 70℃; for 12h; Inert atmosphere;70%
4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

1-bromo-2-methyl-4-(trifluoromethyl)benzene
929000-62-4

1-bromo-2-methyl-4-(trifluoromethyl)benzene

Conditions
ConditionsYield
With sulfur tetrafluoride; hydrogen fluoride at 85℃; for 24h; Autoclave; Inert atmosphere;87%
4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

potassium tert-butylate
865-47-4

potassium tert-butylate

tert-butyl 4-bromo-3-methylbenzoate
347174-28-1

tert-butyl 4-bromo-3-methylbenzoate

Conditions
ConditionsYield
Stage #1: 4-bromo-3-methylbenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 2.33333h;
Stage #2: potassium tert-butylate In tetrahydrofuran at 0 - 20℃; for 1h;
86%
Stage #1: 4-bromo-3-methylbenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane for 2h; Inert atmosphere;
Stage #2: potassium tert-butylate In tetrahydrofuran at 0 - 20℃; for 2h;
69%
Stage #1: 4-bromo-3-methylbenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 4h; Inert atmosphere;
Stage #2: potassium tert-butylate In tetrahydrofuran at 0 - 20℃; for 3h; Inert atmosphere;
42%
Stage #1: 4-bromo-3-methylbenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 2h;
Stage #2: potassium tert-butylate In tetrahydrofuran at 20℃; for 0.5h;
4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

4-bromo-3-(bromomethyl)benzoic acid
887757-31-5

4-bromo-3-(bromomethyl)benzoic acid

Conditions
ConditionsYield
With 2,2'-azobis(isobutyronitrile) In tetrachloromethane for 72h; Concentration; Reflux;86%
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In tetrachloromethane at 76℃; for 72h;86%
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In tetrachloromethane for 48h; Reflux;86%
4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)indoline

4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)indoline

C24H20BrNO3

C24H20BrNO3

Conditions
ConditionsYield
Stage #1: 4-bromo-3-methylbenzoic acid; 4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)indoline With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃;
Stage #2: With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 3h;
85.5%
oxalyl dichloride
79-37-8

oxalyl dichloride

4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

tert-butyl 4-bromo-3-methylbenzoate
347174-28-1

tert-butyl 4-bromo-3-methylbenzoate

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran; N-methyl-acetamide; dichloromethane; water85%
4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

potassium phenyltrifluoborate

potassium phenyltrifluoborate

C14H11BrO2

C14H11BrO2

Conditions
ConditionsYield
With dipotassium hydrogenphosphate; oxygen; palladium diacetate; p-benzoquinone In tert-butyl alcohol at 100℃; under 22801.5 Torr; for 24h; regioselective reaction;85%
4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

methyl iodide
74-88-4

methyl iodide

4-Bromo-3-methylbenzoic acid methyl ester
148547-19-7

4-Bromo-3-methylbenzoic acid methyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 2.5h;83.1%
4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

dimethyl amine
124-40-3

dimethyl amine

4-bromo-N,N,3-trimethylbenzamide

4-bromo-N,N,3-trimethylbenzamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In tetrahydrofuran; dichloromethane at 20℃; for 16h;83%
With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride In ethanol; water at 20℃; for 24h;65%
4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

{2‐azabicyclo[2.1.1]hexan‐1‐yl}methanamine

{2‐azabicyclo[2.1.1]hexan‐1‐yl}methanamine

N‐({2‐benzyl‐2‐azabicyclo[2.1.1]hexan‐1‐yl}methyl)‐4‐bromo‐3‐methylbenzamide

N‐({2‐benzyl‐2‐azabicyclo[2.1.1]hexan‐1‐yl}methyl)‐4‐bromo‐3‐methylbenzamide

Conditions
ConditionsYield
Stage #1: 4-bromo-3-methylbenzoic acid With 1-[(1-(cyano-2-ethoxy-2-oxoethylidenaminooxy)dimethylamino-morpholino)]-uronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.5h;
Stage #2: {2‐azabicyclo[2.1.1]hexan‐1‐yl}methanamine In dichloromethane at 20℃; for 1h;
82%
2-fluoro-N1-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)benzene-1,4-diamine
1428155-04-7

2-fluoro-N1-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)benzene-1,4-diamine

4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

4-bromo-N-(3-fluoro-4-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-ylamino)phenyl)-3-methylbenzamide
1428155-17-2

4-bromo-N-(3-fluoro-4-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-ylamino)phenyl)-3-methylbenzamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane at 0 - 20℃; for 3h; Inert atmosphere;80%
4-bromo-3-methylbenzoic acid
7697-28-1

4-bromo-3-methylbenzoic acid

methyl 6-aminocaproate hydrochloride
1926-80-3

methyl 6-aminocaproate hydrochloride

methyl 6-(4-bromo-3-methylbenzamido)hexanoate
1255952-05-6

methyl 6-(4-bromo-3-methylbenzamido)hexanoate

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trimethylamine In dichloromethane for 20h; Inert atmosphere;78%

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