(S)-3-Hydroxybutyric acid supplier

Name
(S)-3-HYDROXYBUTYRIC ACID
EINECS 228-209-4
CAS No. 6168-83-8
Article Data47
CAS DataBase
Density 1.195 g/cm³
Solubility
Melting Point 45-48 °C
Formula C4H8 O3
Boiling Point 269.2 °C at 760 mmHg
Molecular Weight 104.106
Flash Point 121 °C
Transport Information
Appearance
Safety 26-36
Risk Codes R36/37/38
Molecular Structure
Hazard Symbols
Synonyms Butanoicacid, 3-hydroxy-, (S)-; Butyric acid, 3-hydroxy-, L- (8CI);(+)-3-Hydroxy-n-butyric acid; (+)-3-Hydroxybutyric acid; (3S)-3-Hydroxybutyricacid; (S)-(+)-b-Hydroxybutyricacid; (S)-3-Hydroxybutanoic acid; (S)-3-Hydroxybutyric acid; (S)-b-Hydroxybutanoic acid;L-(+)-3-Hydroxybutyric acid; L-3-Hydroxybutyric acid; L-b-Hydroxybutyric acid
PSA 57.53000
LogP -0.15810

Synthetic route

: 65058-82-4
(S)-(-)-β-methyl-β-propiolactone

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

Conditions

Conditions	Yield
With sodium hydroxide In water at 0℃; for 0.333333h;	71%
With hydrogenchloride In diethyl ether; water for 18h; pH=2;	63%

: 53562-86-0
(S)-3-hydroxybutyric acid methyl ester

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

Conditions

Conditions	Yield
With sodium hydroxide In water for 36h;	53%
With water; potassium hydroxide at 0 - 20℃; for 32h;	50%
With potassium hydroxide In ethanol at 25℃; for 48h;
With potassium hydroxide
With potassium hydroxide at 20℃; for 72h;

: 65058-82-4
(S)-(-)-β-methyl-β-propiolactone

A: 6168-83-8
(S)-3-Hydroxybutanoic Acid

B: 115395-16-9
(R)-3-Mercaptobuttersaeure

Conditions

Conditions	Yield
With sodium hydrogensulfide In water 0 deg C, 1 h, then room temp., 24 h; Yields of byproduct given;	A n/a B 47%

: 4368-06-3
3-hydroxybutanenitrile

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

Conditions

Conditions	Yield
With Rhodococcus erythropolis SET1 cells In aq. phosphate buffer at 25℃; for 24h; pH=7; Microbiological reaction; enantioselective reaction;	42%
With hydrogenchloride
With bacterial isolate In aq. phosphate buffer at 15℃; pH=7.2;	n/a

: 18826-95-4, 107-88-0
1.3-butanediol

A: 24621-61-2
1,3-butanediol

B: 6168-83-8
(S)-3-Hydroxybutanoic Acid

Conditions

Conditions	Yield
With phosphate buffer at 30℃; for 24h; Candida boidinii KK912 (IFO 10574);	A 32% B 13%

: 2835-82-7
3-aminobutyric acid

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

Conditions

Conditions	Yield
With cis-nitrous acid nachfolgend Verseifen;

: 6078-06-4
methyl 3-aminobutyrate

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

Conditions

Conditions	Yield
With cis-nitrous acid nachfolgend Verseifen;

: 107-89-1
acetaldol

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

Conditions

Conditions	Yield
bei der Einw. von Bact. ascendens;

: 541-50-4
2-acetoacetic acid

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

Conditions

Conditions	Yield
bei der Reduktion durch gaerende Hefe;
durch ein stereospezifisches Enzym aus Schweinenieren-Extrakt;

: 300-85-6, 625-71-8
3-Hydroxybutyric acid

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

Conditions

Conditions	Yield
Man laesst auf der Ammoniumsalzloesung Aspergillus griseus wachsen;

: 18826-95-4, 107-88-0
1.3-butanediol

A: 6168-83-8
(S)-3-Hydroxybutanoic Acid

B: 625-72-9
(R)-3-hydroxybutyric acid

C: 541-50-4
2-acetoacetic acid

Conditions

Conditions	Yield
With D-glucose; calcium carbonate at 27℃; for 48h; Hansenula anomala IFO 0195; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With D-glucose; calcium carbonate at 27℃; for 48h; Product distribution; Hansenula anomala IFO 0195, potato-dextrose-agar; other yeasts, influence of glucose, fructose, temperature: stereoselectivity; also with optically active 1,3-butanediol;

...Expand

: 541-50-4
2-acetoacetic acid

A: 6168-83-8
(S)-3-Hydroxybutanoic Acid

B: 625-72-9
(R)-3-hydroxybutyric acid

Conditions

Conditions	Yield
With potassium dihydrogenphosphate; baker's yeast; D-glucose In water at 28℃; for 9h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
With potassium dihydrogenphosphate; baker's yeast; D-glucose In water at 28℃; for 9h; Product distribution; other times; other β-keto acids investigated;
With diisopinocampheylborane In tetrahydrofuran at 20℃; for 32h; Title compound not separated from byproducts.;

: 56816-01-4
ethyl (S)-3-hydroxybutyrate

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

Conditions

Conditions	Yield
With potassium hydroxide for 12h; Ambient temperature;
With Candida antarctica lipase B; 4-nitro-phenol; MOPS buffer In water at 25℃; pH=7.2; Enzyme kinetics; Further Variations:; Reagents; Enzymatic reaction;

: 141-97-9
ethyl acetoacetate

A: 6168-83-8
(S)-3-Hydroxybutanoic Acid

B: 625-72-9
(R)-3-hydroxybutyric acid

C: 24915-95-5
Ethyl (R)-3-hydroxybutanoate

D: 56816-01-4
ethyl (S)-3-hydroxybutyrate

Conditions

Conditions	Yield
With Halobacterium halobium; pepton; potassium chloride; water; sodium citrate; magnesium sulfate; sodium chloride at 40℃; for 120h; Irradiation; Yields of byproduct given. Title compound not separated from byproducts;
With Halobacterium halobium; pepton; potassium chloride; sodium citrate; magnesium sulfate; sodium chloride In water at 40℃; for 120h; Irradiation; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

...Expand

: 108379-02-8
(S)-(-)-2,3-Dihydro-2-methyl-4H-1-benzopyran-4-one

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

Conditions

Conditions	Yield
With ozone In water; acetic acid for 2h;

: 105252-84-4
1'(R),6-Dimethyl-4'(S)-isopropyl-4-oxospiro--dioxin>

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

Conditions

Conditions	Yield
With hydrogen; platinum(IV) oxide In methanol Ambient temperature;

: 2-hydroxymuconate disodium salt

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

Conditions

Conditions	Yield
With sodium dihydrogenphosphate; manganese(ll) chloride 1.) 4-oxalocrotonate tautomerase (4-OT), RT, 2 h, 2.) oxalocrotonate decarboxylase, vinylpyruvate hydratase, RT, 1.5 h; Multistep reaction;

: l-menthyl (2S,6S)-6-methyl-4-oxo-1,3-dioxane-2-carboxylate

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

Conditions

Conditions	Yield
With potassium hydroxide In methanol at 50℃; for 0.0833333h;

: 182970-04-3
(S)-3-(benzyloxy)butanoic acid

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal In ethyl acetate for 5h;

(+-)-3-hydroxy-butyric acid: (+-)-3-hydroxy-butyric acid

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

Conditions

Conditions	Yield
With Quinine

potassium-salt of/the/ acetoacetic acid: potassium-salt of/the/ acetoacetic acid

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

Conditions

Conditions	Yield
With Baecker-yeast

: 53562-86-0
(S)-3-hydroxybutyric acid methyl ester

A: 67-56-1
methanol

B: 6168-83-8
(S)-3-Hydroxybutanoic Acid

Conditions

Conditions	Yield
With 2-(di(2-hydroxyethyl)amino)ethanesulfonic acid; lipase from Ophiostoma piliferum In water at 25℃; pH=7.20; Enzyme kinetics;
With 2-(di(2-hydroxyethyl)amino)ethanesulfonic acid; lipase from Bacillus thermocatenulanatus In water at 40℃; pH=7.20; Enzyme kinetics;

: 56816-01-4
ethyl (S)-3-hydroxybutyrate

A: 64-17-5
ethanol

B: 6168-83-8
(S)-3-Hydroxybutanoic Acid

Conditions

Conditions	Yield
With 2-(di(2-hydroxyethyl)amino)ethanesulfonic acid; lipase from Ophiostoma piliferum In water at 25℃; pH=7.20; Enzyme kinetics;
With 2-(di(2-hydroxyethyl)amino)ethanesulfonic acid; lipase from Bacillus thermocatenulanatus In water at 40℃; pH=7.20; Enzyme kinetics;

: 6-Methyl-2-((1R,2S,3R,5R)-2,6,6-trimethyl-bicyclo[3.1.1]hept-3-yl)-[1,3,2]dioxaborinan-4-one

A: 6168-83-8
(S)-3-Hydroxybutanoic Acid

B: 625-72-9
(R)-3-hydroxybutyric acid

Conditions

Conditions	Yield
With sodium hydroxide; dihydrogen peroxide In tetrahydrofuran Title compound not separated from byproducts.;

: 117706-98-6
(S)-3-hydroxybutyraldehyde

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

Conditions

Conditions	Yield
With sodium chlorite

: 1190432-98-4
perennisaponin I

A: 6168-83-8
(S)-3-Hydroxybutanoic Acid

B: 121324-22-9
polygalacic acid 3-(α-L-rhamnopyranoside)

C: 64-19-7
acetic acid

Conditions

Conditions	Yield
With potassium hydroxide In 1,4-dioxane; water at 40℃; for 12h;	A n/a B 2 mg C n/a

...Expand

: 1190433-12-5
perennisaponin J

A: 6168-83-8
(S)-3-Hydroxybutanoic Acid

B: 121324-22-9
polygalacic acid 3-(α-L-rhamnopyranoside)

C: 64-19-7
acetic acid

Conditions

Conditions	Yield
With potassium hydroxide In 1,4-dioxane; water at 40℃; for 12h;	A n/a B 2 mg C n/a

...Expand

: 1190433-29-4
perennisaponin K

A: 6168-83-8
(S)-3-Hydroxybutanoic Acid

B: 121324-22-9
polygalacic acid 3-(α-L-rhamnopyranoside)

C: 64-19-7
acetic acid

Conditions

Conditions	Yield
With potassium hydroxide In 1,4-dioxane; water at 40℃; for 12h;	A n/a B 2 mg C n/a

...Expand

: 1190433-46-5
perennisaponin L

A: 6168-83-8
(S)-3-Hydroxybutanoic Acid

B: 121324-22-9
polygalacic acid 3-(α-L-rhamnopyranoside)

C: 64-19-7
acetic acid

Conditions

Conditions	Yield
With potassium hydroxide In 1,4-dioxane; water at 40℃; for 12h;	A n/a B 2 mg C n/a

...Expand

: 390800-88-1
bortezomib

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

: 1201902-96-6
N-[(1S)-1-benzyl-2-({(1R)-3-methyl-1-[(4S)-4-methyl-6-oxo-1,3,2-dioxaborinan-2-yl]butyl}amino)-2-oxoethyl]pyrazine-2-carboxamide

Conditions

Conditions	Yield
In ethyl acetate at 25 - 60℃;	96%

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

: 1201903-03-8
Ν,Ν',Ν''-[boroxin-2,4,6-triyltris[[(1R)-3-methylbutane-1,1-diyl]imino(2-oxoethane-2,1-diyl)]]tris(2,5-dichlorobenzamide)

: 1201902-87-5
2,5-dichloro-N-[2-({(1R)-3-methyl-1-[(4S)-4-methyl-6-oxo-1,3,2-dioxaborinan-2-yl]butyl}amino)-2-oxoethyl]benzamide

Conditions

Conditions	Yield
In ethyl acetate at 25 - 60℃;	95%

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

: 100-51-6
benzyl alcohol

: 127604-17-5
3-hydroxybutyric acid benzyl ester

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In chloroform at 0℃; for 6h;	89%

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

: 1222106-77-5
5-{9-isobutyl-6-[(3S)-3-methylmorpholin-4-yl]-8-piperazin-1-yl-9H-purin-2-yl}pyrimidin-2-amine

: 1222105-18-1
(2S)-4-(4-{2-(2-Aminopyrimidin-5-yl)-9-isobutyl-6-[(3S)-3-methylmorpholin-4-yl]-9H-purin-8-yl}piperazin-1-yl)-4-oxobutan-2-ol

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 21h;	81%

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

: 104-94-9
4-methoxy-aniline

: 127604-09-5
(S)-3-hydroxy-N-(4-methoxyphenyl)butanamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane at 0 - 20℃; Inert atmosphere;	75%

: 64-17-5
ethanol

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

: 56816-01-4
ethyl (S)-3-hydroxybutyrate

Conditions

Conditions	Yield
With sulfuric acid	73%
With sulfuric acid	73%

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

: 195006-98-5
benzyl 2-amino-(R)-4,6-O-benzylidene-2-deoxy-β-D-allopyranoside

: benzyl (R)-4,6-O-benzylidene-2-deoxy-2-[(S)-3-hydroxybutanamido]-β-D-allopyranoside

Conditions

Conditions	Yield
With 1-hydroxy-pyrrolidine-2,5-dione; triethylamine; dicyclohexyl-carbodiimide In 1,4-dioxane at 20℃;	72%

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

: 1620576-76-2
3-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-5-(1-methyl-3-(piperidin-4-yl)-1H-1,2,4-triazol-5-yl)pyrazin-2-amine

: 1620576-66-0
(3S)-1-[4-[5-[5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl]-1-methyl-1,2,4-triazol-3-yl]-1-piperidyl]-3-hydroxy-butan-1-one

Conditions

Conditions	Yield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere;	68%

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

: (R)-N-(6-(1-(1-((tert-butyldimethylsilyl)oxy)propan-2-yl)-1H-tetrazol-5-yl)pyridin-2-yl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-7-carboxamide

: 2-((S)-3-hydroxybutanoyl)-N-(6-(1-((R)-1-hydroxypropan-2-yl)-1H-tetrazol-5-yl)pyridin-2-yl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-7-carboxamide

Conditions

Conditions	Yield
Stage #1: (S)-3-Hydroxybutanoic Acid; (R)-N-(6-(1-(1-((tert-butyldimethylsilyl)oxy)propan-2-yl)-1H-tetrazol-5-yl)pyridin-2-yl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-7-carboxamide With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 2h; Stage #2: With hydrogenchloride In water; N,N-dimethyl-formamide at 20℃; for 1h;	66%

Yield

Stage #1: (S)-3-Hydroxybutanoic Acid; (R)-N-(6-(1-(1-((tert-butyldimethylsilyl)oxy)propan-2-yl)-1H-tetrazol-5-yl)pyridin-2-yl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-7-carboxamide With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 2h;
Stage #2: With hydrogenchloride In water; N,N-dimethyl-formamide at 20℃; for 1h;

66%

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

: 26081-03-8, 26081-07-2, 29110-16-5, 29426-64-0, 40862-36-0
(S)-3-aminocaprolactam hydrochloride

: (S)-3-[(S)-3-hydroxybutyramido]-hexahydro-2-azepinone

Conditions

Conditions	Yield
With dmap; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 24h;	62%

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

: 1222104-29-1
5-{9-isobutyl-8-[(3R)-3-methylpiperazin-1-yl]-6-morpholin-4-yl-9H-purin-2-yl}pyrimidin-2-amine

: 1222104-71-3
(2S)-4-{(2R)-4-[2-(2-Aminopyrimidin-5-yl)-9-isobutyl-6-morpholin-4-yl-9H-purin-8-yl]-2-methylpiperazin-1-yl}-4-oxobutan-2-ol

Conditions

Conditions	Yield
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 40℃; for 16h;	61%

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

: 1222105-31-8
5-(9-isobutyl-6-morpholin-4-yl-8-piperazin-1-yl-9H-purin-2-yl)pyrimidin-2-amine

: 1222104-67-7
(2S)-4-{4-[2-(2-Aminopyrimidin-5-yl)-9-isobutyl-6-morpholin-4-yl-9H-purin-8-yl]piperazin-1-yl}-4-oxobutan-2-ol

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide for 16h;	56%

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

: (3aS,6aR)-2-(1-(2-fluorophenyl)-1H-indazol-4-yl)hexahydropyrrolo[3,4-c]pyrrol-1(2H)-one

: (3aS,6aR)-2-[1-(2-fluorophenyl)-1H-indazol-4-yl]-5-[(3S)-3-hydroxybutanoyl]hexahydropyrrolo[3,4-c]pyrrol-1(2H)-one

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In tetrahydrofuran at 20℃; for 3h;	53%

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

: 5-[6-morpholin-4-yl-8-piperazin-1-yl-9-(2,2,2-trifluoroethyl)-9H-purin-2-yl]pyrimidin-2-amine trifluoroacetate

: 1222104-55-3
(2S)-4-{4-[2-(2-Aminopyrimidin-5-yl)-6-morpholin-4-yl-9-(2,2,2-trifluoroethyl)-9H-purin-8-yl]piperazin-1-yl}-4-oxobutan-2-ol

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide for 15h;	50%

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

: 630-19-3
pivalaldehyde

: (2S,6S)-2-tert-Butyl-6-methyl-[1,3]dioxan-4-one

Conditions

Conditions	Yield
With Dowex 50W In dichloromethane Cyclization; Etherification; Heating;	48%

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

: 1222104-28-0
5-{9-isobutyl-8-[(3S)-3-methylpiperazin-1-yl]-6-morpholin-4-yl-9H-purin-2-yl}pyrimidin-2-amine

: 1222104-70-2
(2S)-4-{(2S)-4-[2-(2-Aminopyrimidin-5-yl)-9-isobutyl-6-morpholin-4-yl-9H-purin-8-yl]-2-methylpiperazin-1-yl}-4-oxobutan-2-ol

Conditions

Conditions	Yield
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 40℃; for 16h;	48%

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

: 18598-63-5
L-cysteine methyl ester hydrochloride

: 676346-96-6
methyl (R)-2-((S)-3-hydroxybutyrylamino)-3-mercaptopropionate

Conditions

Conditions	Yield
With 4-methyl-morpholine; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In acetonitrile at 0℃; for 3h;	42%

: 167308-64-7
3-{[(R)-2,2,5,5-tetramethyl-1,3-dioxan-4-yl]carbonylamino}-1-(2-mercaptoethylamino)-1-propanone

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

: 538-37-4
dibenzyl phosphochloridate

Conditions

Conditions	Yield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 16h;	40.56%

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

: (3aR,6aS)-2-[1-(2-fluorophenyl)-1H-indazol-4-yl]hexahydropyrrolo[3,4-c]pyrrol-1(2H)-one

: (3aR,6aS)-2-[1-(2-fluorophenyl)-1H-indazol-4-yl]-5-[(3S)-3-hydroxybutanoyl]hexahydropyrrolo[3,4-c]pyrrol-1(2H)-one

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In tetrahydrofuran at 20℃; for 16h;	40%

: 4-(4-aminophenyl)-N-(4-morpholin-4-ylphenyl)pyrimidin-2-amine

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

: (S)-3-hydroxy-N-(4-(2-(4-{morpholinophenyl}amino)pyrimidin-4-yl)phenyl)butanamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 2h;	22%

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

A: 116838-42-7
(4S,8S,12S,16S,20S)-4,8,12,16,20-Pentamethyl-1,5,9,13,17-pentaoxa-cycloicosane-2,6,10,14,18-pentaone

B: 116838-43-8
(4S,8S,12S,16S,20S,24S)-4,8,12,16,20,24-Hexamethyl-1,5,9,13,17,21-hexaoxa-cyclotetracosane-2,6,10,14,18,22-hexaone

C: 116838-44-9
(4S,8S,12S,16S,20S,24S,28S)-4,8,12,16,20,24,28-Heptamethyl-1,5,9,13,17,21,25-heptaoxa-cyclooctacosane-2,6,10,14,18,22,26-heptaone

Conditions

Conditions	Yield
With 2,4,6-trichlorobenzoyl chloride; triethylamine In tetrahydrofuran 1.) 0 deg C, 30 min, 2.) 0 deg C to room temperature, 1.5 h;	A 13% B 13% C 7%
With trichlorobenzoyl chloride; triethylamine In tetrahydrofuran 1.) 0 deg C, 30 min, 2.) 0 deg C to room temperature, 1.5 h;	A 13% B 13% C 7%
With 2,4,6-trichlorobenzoyl chloride; triethylamine In tetrahydrofuran 1.) 0 deg C, 30 min, 2.) 0 deg C to room temperature;	A 13% B 13% C 7%

...Expand

: 186581-53-3, 908094-01-9
diazomethane

: 6168-83-8
(S)-3-Hydroxybutanoic Acid

: 53562-86-0
(S)-3-hydroxybutyric acid methyl ester

Conditions

Conditions	Yield
In diethyl ether	12%
With diethyl ether
In diethyl ether Yield given;
In diethyl ether for 0.166667h; Ambient temperature; Yield given;

(S)-3-Hydroxybutyric acid Chemical Properties

Molecular structure of (S)-3-Hydroxybutyric acid (CAS NO.6168-83-8) is:

Product Name: (S)-3-Hydroxybutyric acid
CAS Registry Number: 6168-83-8
IUPAC Name: (3S)-3-hydroxybutanoic acid
Molecular Weight: 104.10452 [g/mol]
Molecular Formula: C₄H₈O₃
XLogP3-AA: -0.5
H-Bond Donor: 2
H-Bond Acceptor: 3
Melting Point: 45-48 °C
Storage temp.: 2-8 °C
Index of Refraction: 1.455
Molar Refractivity: 23.63 cm³
Molar Volume: 87 cm³
Surface Tension: 46.3 dyne/cm
Density: 1.195 g/cm³
Flash Point: 121 °C
Enthalpy of Vaporization: 58.91 kJ/mol
Boiling Point: 269.2 °C at 760 mmHg
Vapour Pressure: 0.000979 mmHg at 25°C
EINECS: 228-209-4
Product Categories: Carboxylic Acids;Chiral Building Blocks;Organic Building Blocks

(S)-3-Hydroxybutyric acid Safety Profile

Safty information about (S)-3-Hydroxybutyric acid (CAS NO.6168-83-8) is:
Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 3
F: 3-10

(S)-3-Hydroxybutyric acid Specification

(S)-3-Hydroxybutyric acid , its cas register number is 6168-83-8. It also can be called beta-Hydroxybutyrate, L- ; beta-Hydroxybutyrate,l .

Product Name

(S)-3-HYDROXYBUTYRIC ACID

Synthetic route

(S)-3-Hydroxybutyric acid Chemical Properties

(S)-3-Hydroxybutyric acid Safety Profile

(S)-3-Hydroxybutyric acid Specification

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