1,2-Diphenoxyethane supplier

Name
1,2-Diphenoxyethane
EINECS 203-224-9
CAS No. 104-66-5
Article Data45
CAS DataBase
Density 1.08 g/cm³
Solubility 22mg/L at 25℃
Melting Point 94-96 °C(lit.)
Formula C₁₄H₁₄O₂
Boiling Point 341.555 °C at 760 mmHg
Molecular Weight 214.264
Flash Point 139.355 °C
Transport Information
Appearance Off-white crystals
Safety 22-24/25
Risk Codes 51/53
Molecular Structure
Hazard Symbols
Synonyms Ethane,1,2-diphenoxy- (6CI,7CI,8CI);2-Phenoxyethyl phenyl ether;Ethylene glycol diphenyl ether;NSC 6794;
PSA 18.46000
LogP 3.14440

Synthetic route

: 30752-35-3
1-(4-bromophenoxy)-2-phenoxyethane

: 104-66-5
1,2-diphenoxyethane

Conditions

Conditions	Yield
Stage #1: 1-(4-bromophenoxy)-2-phenoxyethane In tetrahydrofuran at 0℃; for 0.0833333h; Stage #2: With hydrogenchloride In tetrahydrofuran Further stages.;	99%

: 591-50-4
iodobenzene

: 107-21-1
ethylene glycol

: 104-66-5
1,2-diphenoxyethane

Conditions

Conditions	Yield
With [2,2]bipyridinyl; copper(l) iodide; sodium carbonate In N,N-dimethyl-formamide at 100℃;	94%

: 122-99-6
2-Phenoxyethanol

: 28899-97-0
triphenylbismuth(V) diacetate

: 104-66-5
1,2-diphenoxyethane

Conditions

Conditions	Yield
	92%

: 108-86-1
bromobenzene

: 107-21-1
ethylene glycol

: 104-66-5
1,2-diphenoxyethane

Conditions

Conditions	Yield
With [2,2]bipyridinyl; copper(l) iodide; sodium carbonate In N,N-dimethyl-formamide at 100℃; Reagent/catalyst;	91%

: 108-95-2
phenol

: 622-86-6
2-chloroethoxybenzene

: 104-66-5
1,2-diphenoxyethane

Conditions

Conditions	Yield
With 1,8-diazabicyclo[5.4.0]undec-7-ene at 130℃; Reagent/catalyst; Large scale;	89.82%

: 107-06-2
1,2-dichloro-ethane

: 108-95-2
phenol

: 104-66-5
1,2-diphenoxyethane

Conditions

Conditions	Yield
Stage #1: 1,2-dichloro-ethane; phenol With sodium carbonate; potassium carbonate at 130 - 160℃; for 6h; Industrial scale; Stage #2: With potassium hydroxide Time; Reagent/catalyst; Industrial scale;	83.6%
With iron(III) hydroxide; sodium carbonate; potassium carbonate In N,N-dimethyl-formamide at 80℃; for 6h; Sealed tube;	40%
With sodium hydroxide; cetyltrimethylammonim bromide 1.) 60 deg C, 0.5 h 2.) 80 deg C, 5 h; Yield given. Multistep reaction;

: 122-99-6
2-Phenoxyethanol

: 88284-48-4
2-(trimethylsilyl)phenyl trifluoromethanesulfonate

: 104-66-5
1,2-diphenoxyethane

Conditions

Conditions	Yield
With potassium fluoride; 18-crown-6 ether In tetrahydrofuran at -20℃; for 12h; Inert atmosphere; Sealed tube;	79%

: 107-21-1
ethylene glycol

: 108-90-7
chlorobenzene

: 104-66-5
1,2-diphenoxyethane

Conditions

Conditions	Yield
With [2,2]bipyridinyl; copper(l) iodide; sodium carbonate In N,N-dimethyl-formamide at 100℃;	74%

: 122-59-8
2-phenoxyacetic acid

: 104-66-5
1,2-diphenoxyethane

Conditions

Conditions	Yield
With titanium(IV) oxide In acetonitrile at 20℃; for 18h; Reagent/catalyst; Schlenk technique; Inert atmosphere; UV-irradiation;	53%
With sodium In pyridine; methanol at 20℃; electrolysis, glasslike-hard carbon anode (GC-E), other anodes;	44%
With benzophenone In benzene Irradiation;

: 122-59-8
2-phenoxyacetic acid

A: 621-87-4
3-phenoxy-2-propanone

B: 104-66-5
1,2-diphenoxyethane

C: 108-95-2
phenol

Conditions

Conditions	Yield
With Pt on TiO2 In acetonitrile for 21h; UV-irradiation; Inert atmosphere;	A n/a B 53% C n/a

...Expand

: 75-05-8
acetonitrile

: 122-59-8
2-phenoxyacetic acid

A: 621-87-4
3-phenoxy-2-propanone

B: 104-66-5
1,2-diphenoxyethane

C: 108-95-2
phenol

Conditions

Conditions	Yield
at 20℃; for 21h; Reagent/catalyst; Schlenk technique; Inert atmosphere; UV-irradiation;	A 11 %Spectr. B 53% C 6 %Spectr.

...Expand

: 106-93-4
ethylene dibromide

: 108-95-2
phenol

: 104-66-5
1,2-diphenoxyethane

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 96h; Reflux;	50%
at 140℃; Reaktion von Kaliumphenolat;
With potassium hydroxide In ethanol for 3h; Heating;

: 100-67-4
potassium phenolate

: 104-66-5
1,2-diphenoxyethane

Conditions

Conditions	Yield
With water; 1,2-dichloro-ethane

: 139-02-6
sodium phenoxide

: 107-06-2
1,2-dichloro-ethane

: 104-66-5
1,2-diphenoxyethane

: 64-17-5
ethanol

: 107-06-2
1,2-dichloro-ethane

: 108-95-2
phenol

: 104-66-5
1,2-diphenoxyethane

Conditions

Conditions	Yield
Reaktion von Natriumphenolat;

...Expand

: 64-17-5
ethanol

: 107-04-0
1-Bromo-2-chloroethane

: 108-95-2
phenol

A: 104-66-5
1,2-diphenoxyethane

B: 622-86-6
2-chloroethoxybenzene

Conditions

Conditions	Yield
Reaktion von Kaliumphenolat;

...Expand

: 100-67-4
potassium phenolate

: 106-93-4
ethylene dibromide

: 104-66-5
1,2-diphenoxyethane

Conditions

Conditions	Yield
With ethanol
at 140℃; im geschlossenen Rohr;

: 139-02-6
sodium phenoxide

: 106-93-4
ethylene dibromide

: 104-66-5
1,2-diphenoxyethane

Conditions

Conditions	Yield
With copper; xylene

: 139-02-6
sodium phenoxide

: 106-93-4
ethylene dibromide

A: 104-66-5
1,2-diphenoxyethane

B: 589-10-6
phenoxyethyl bromide

Conditions

Conditions	Yield
With ethanol

...Expand

: 56-23-5
tetrachloromethane

: 64-17-5
ethanol

: 106-93-4
ethylene dibromide

: 108-95-2
phenol

A: 104-66-5
1,2-diphenoxyethane

B: 589-10-6
phenoxyethyl bromide

...Expand

: 64-17-5
ethanol

: 106-93-4
ethylene dibromide

: 108-95-2
phenol

A: 104-66-5
1,2-diphenoxyethane

B: 589-10-6
phenoxyethyl bromide

Conditions

Conditions	Yield
Reaktion von Natriumphenolat;

...Expand

: 80-41-1
2-chloroethyl tosylate

: furan-2,3,5(4H)-trione pyridine (1:1)

: 108-95-2
phenol

A: 104-66-5
1,2-diphenoxyethane

B: 622-86-6
2-chloroethoxybenzene

...Expand

: 6315-52-2
1,2-bis-tosyloxyethane

: 108-95-2
phenol

: 104-66-5
1,2-diphenoxyethane

Conditions

Conditions	Yield
With sodium hydroxide at 105℃;
With sodium hydroxide In water Heating;

: 122-59-8
2-phenoxyacetic acid

A: 2555-49-9
phenoxyacetic acid ethyl ester

B: 104-66-5
1,2-diphenoxyethane

Conditions

Conditions	Yield
With pyridine In ethanol (electrolysis);

: 107-06-2
1,2-dichloro-ethane

: 108-95-2
phenol

alcoholic NaOH: alcoholic NaOH

A: 766-94-9
vinyl phenyl ether

B: 104-66-5
1,2-diphenoxyethane

Conditions

Conditions	Yield
at 180 - 200℃; unter Druck; reagiert analog mit anderen Phenolen;

...Expand

: 56-23-5
tetrachloromethane

: 106-93-4
ethylene dibromide

: 108-95-2
phenol

copper: copper

: 104-66-5
1,2-diphenoxyethane

Conditions

Conditions	Yield
Reaktion von Natriumphenolat;

...Expand

: 56-23-5
tetrachloromethane

: 80-41-1
2-chloroethyl tosylate

: 7732-18-5
water

: 108-95-2
phenol

A: 104-66-5
1,2-diphenoxyethane

B: 622-86-6
2-chloroethoxybenzene

...Expand

: 80-41-1
2-chloroethyl tosylate

aqueous sodium phenolate: aqueous sodium phenolate

: 104-66-5
1,2-diphenoxyethane

: 122-59-8
2-phenoxyacetic acid

potassium phenoxy acetate: potassium phenoxy acetate

: 104-66-5
1,2-diphenoxyethane

Conditions

Conditions	Yield
With pyridine; methanol Electrolysis;

: 104-66-5
1,2-diphenoxyethane

: 129633-44-9
1,2-Bis(2,4-dibromophenoxy)ethane

Conditions

Conditions	Yield
With benzyltrimethylazanium tribroman-2-uide; zinc(II) chloride In acetic acid at 70℃; for 2h;	98%

: 104-66-5
1,2-diphenoxyethane

: 117934-82-4
1,2-bis(4-iodophenoxy)ethane

Conditions

Conditions	Yield
With N,N,N-trimethylbenzenemethanaminium dichloroiodate; zinc(II) chloride In acetic acid for 4h; Ambient temperature;	95%

: 104-66-5
1,2-diphenoxyethane

: 1,2-dicyclohexoxyethane

Conditions

Conditions	Yield
With hydrogen; Rh/Al2O3 In ethanol at 40℃; under 31028.9 Torr; for 20h;	95%

: 104-66-5
1,2-diphenoxyethane

EtCO-acylating educt: EtCO-acylating educt

: 103509-19-9
1,1'-((ethane-1,2-diylbis(oxy))bis(4,1-phenylene))bis(propan-1-one)

Conditions

Conditions	Yield
Acylation;	94%

: 104-66-5
1,2-diphenoxyethane

: 10026-12-7
niobium pentachloride

: 1236036-63-7
(NbCl5)2[μ-κ2-1,2-diphenoxyethane]

Conditions

Conditions	Yield
In dichloromethane under Ar using standard Schlenk techniques; suspn. of NbCl5 (0.45 mmol)and 1,2-diphenoxyethane (0.20 mmol) stirred (5 h); filtered; dried (vac.); crystd. from CH2Cl2/pentane (-20°C); elem. anal.;	91%

: 7783-68-8
niobium pentafluoride

: 104-66-5
1,2-diphenoxyethane

: 1236036-61-5
(NbF5)2[μ-κ2-1,2-diphenoxyethane]

Conditions

Conditions	Yield
In dichloromethane under Ar using standard Schlenk techniques; suspn. of TaCl5 (0.45 mmol)and 1,2-diphenoxyethane (0.20 mmol) stirred (5 h); filtered; dried (vac.); crystd. from CH2Cl2/pentane (-20°C); elem. anal.;	91%

: 7783-71-3
tantalum pentafluoride

: 104-66-5
1,2-diphenoxyethane

: 1236036-62-6
(TaF5)2[μ-κ2-1,2-diphenoxyethane]

Conditions

Conditions	Yield
In dichloromethane under Ar using standard Schlenk techniques; suspn. of TaF5 (0.45 mmol) and 1,2-diphenoxyethane (0.20 mmol) stirred (5 h); filtered; dried (vac.); crystd. from CH2Cl2/pentane (-20°C); elem. anal.;	88%

: 104-66-5
1,2-diphenoxyethane

: 36506-46-4
4,4'-(ethylenedioxy)dibromobenzene

Conditions

Conditions	Yield
With bromine In acetic acid for 1h; Ambient temperature;	86%
With bromine; acetic acid

: 104-66-5
1,2-diphenoxyethane

: 7721-01-9
tantalum pentachloride

: 1236036-64-8
(TaCl5)2[μ-κ2-1,2-diphenoxyethane]

Conditions

Conditions	Yield
In dichloromethane under Ar using standard Schlenk techniques; suspn. of TaCl5 (0.45 mmol)and 1,2-diphenoxyethane (0.20 mmol) stirred (5 h); filtered; dried (vac.); crystd. from CH2Cl2/pentane (-20°C); elem. anal.;	84%

: 358-23-6
trifluoromethylsulfonic anhydride

: 945-51-7
1,1'-sulfinylbisbenzene

: 104-66-5
1,2-diphenoxyethane

: 1383805-12-6
diphenyl(diphenoxyethane)sulfonium triflate

Conditions

Conditions	Yield
In dichloromethane at -40℃; for 2h; Cooling with acetone-dry ice;	68%

...Expand

: 104-66-5
1,2-diphenoxyethane

: 1270940-74-3
C14H13IO2

Conditions

Conditions	Yield
With N-iodo-succinimide In trifluorormethanesulfonic acid at -20℃; for 0.333333h;	62%

: 507-40-4
tert-butylhypochlorite

: 104-66-5
1,2-diphenoxyethane

A: 73421-42-8
1-chloro-1,2-diphenoxy ethane

B: 1,2-dichlorodiphenoxy ethane

Conditions

Conditions	Yield
In benzene at 20℃; for 0.25h; Irradiation;	A 38% B 21%

...Expand

: 104-66-5
1,2-diphenoxyethane

A: 73421-42-8
1-chloro-1,2-diphenoxy ethane

B: 1,2-dichlorodiphenoxy ethane

Conditions

Conditions	Yield
With tert-butylhypochlorite In benzene at 20℃; for 0.25h;	A 38% B 21%

: 104-66-5
1,2-diphenoxyethane

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 34074-28-7
1,2-bis(4-formylphenoxy)ethane

Conditions

Conditions	Yield
With trichlorophosphate for 12h;	30%

: 56-23-5
tetrachloromethane

: 104-66-5
1,2-diphenoxyethane

A: 51-28-5
2,4-Dinitrophenol

B: 14467-69-7
1,2-bis(4-nitrophenoxy)ethane

...Expand

: 74-90-8
hydrogen cyanide

: 104-66-5
1,2-diphenoxyethane

: 34074-28-7
1,2-bis(4-formylphenoxy)ethane

Conditions

Conditions	Yield
With hydrogenchloride; aluminium trichloride; benzene unter allmaechlichem Erwaermen von 0gradC auf 30-40gradC und Zersetzung des Reaktionsproduktes durch Kochen mit verd. Salzsaeure;

: 463-72-9
carbamic chloride

: 104-66-5
1,2-diphenoxyethane

: 4,4'-ethanediyldioxy-di-benzoic acid diamide

Conditions

Conditions	Yield
With carbon disulfide; aluminium trichloride

: 104-66-5
1,2-diphenoxyethane

: 14467-69-7
1,2-bis(4-nitrophenoxy)ethane

Conditions

Conditions	Yield
With nitric acid
With tetrachloromethane; dinitrogen tetraoxide

1,2-Diphenoxyethane Specification

The cas register number of 1,2-Diphenoxyethane is 104-66-5. It also can be called as 2-Phenoxyethyl phenyl ether and the Systematic name about this chemical is 2-phenoxyethoxybenzene.

Physical properties about 1,2-Diphenoxyethane are: (1)ACD/LogP: 3.81; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 3.81; (4)ACD/LogD (pH 7.4): 3.81; (5)ACD/BCF (pH 5.5): 462.88; (6)ACD/BCF (pH 7.4): 462.88; (7)ACD/KOC (pH 5.5): 2815.45; (8)ACD/KOC (pH 7.4): 2815.45; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 5; (12)Polar Surface Area: 18.46Å²; (13)Index of Refraction: 1.556; (14)Molar Refractivity: 63.81 cm³; (15)Molar Volume: 198.3 cm³; (16)Surface Tension: 39 dyne/cm; (17)Density: 1.08 g/cm³; (18)Flash Point: 139.4 °C; (19)Enthalpy of Vaporization: 56.21 kJ/mol; (20)Boiling Point: 341.6 °C at 760 mmHg; (21)Vapour Pressure: 0.000158 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
People do not breathe dust and avoid contact with skin and eyes.

People can use the following data to convert to the molecule structure.
1.SMILES: O(c1ccccc1)CCOc2ccccc2
2.InChI: InChI=1/C14H14O2/c1-3-7-13(8-4-1)15-11-12-16-14-9-5-2-6-10-14/h1-10H,11-12H2
3.InChIKey: XCSGHNKDXGYELG-UHFFFAOYAH
4.Std. InChI: InChI=1S/C14H14O2/c1-3-7-13(8-4-1)15-11-12-16-14-9-5-2-6-10-14/h1-10H,11-12H2.

Product Name

1,2-Diphenoxyethane

Synthetic route

1,2-Diphenoxyethane Specification

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