Conditions | Yield |
---|---|
In isopropyl alcohol at 180℃; under 3750.38 Torr; for 8h; Inert atmosphere; Autoclave; | 100% |
With sulfuric acid; hydrogen; Ni/Re pH=6.9 - 12.1; Industry scale; | 99% |
With hydrogen In 1,4-dioxane at 179.84℃; under 7500.75 Torr; for 6h; Time; Reagent/catalyst; Autoclave; | 99% |
methyloxirane
propylene glycol
Conditions | Yield |
---|---|
With CoIII(t-Bu-salen)-OTs; water at 40℃; for 0.5h; Catalytic behavior; Reagent/catalyst; Autoclave; | 99% |
With sulfuric acid; water at 27℃; for 6h; | 98.3% |
With water at 40℃; for 3h; Catalytic behavior; Reagent/catalyst; Schlenk technique; | 93% |
Conditions | Yield |
---|---|
With [carbonylchlorohydrido{bis[2-(diphenylphosphinomethyl)ethyl]amino}ethylamino] ruthenium(II); potassium tert-butylate; hydrogen In tetrahydrofuran at 140℃; under 38002.6 Torr; for 10h; Catalytic behavior; Temperature; Time; Solvent; Pressure; Autoclave; | 99% |
With potassium tert-butylate; hydrogen; C16H18BrCoINO2 In dibutyl ether at 160℃; under 45004.5 Torr; for 20h; Reagent/catalyst; Sealed tube; Autoclave; | 92% |
With water; aluminum hydroxide; magnesium hydroxide at 140℃; Conversion of starting material; |
carbon dioxide
4-fluoroaniline
methyloxirane
A
propylene glycol
Conditions | Yield |
---|---|
With C24H25N4O3(1+)*I(1-); 1,8-diazabicyclo[5.4.0]undec-7-ene at 90℃; under 3750.38 Torr; for 4h; Autoclave; | A n/a B 99% |
carbon dioxide
4-chloro-aniline
methyloxirane
A
propylene glycol
B
3-(4-chlorophenyl)-5-methyloxazolidin-2-one
Conditions | Yield |
---|---|
With C24H25N4O3(1+)*I(1-); 1,8-diazabicyclo[5.4.0]undec-7-ene at 90℃; under 3750.38 Torr; for 4h; Autoclave; | A n/a B 99% |
carbon dioxide
4-bromo-aniline
methyloxirane
A
propylene glycol
Conditions | Yield |
---|---|
With C24H25N4O3(1+)*I(1-); 1,8-diazabicyclo[5.4.0]undec-7-ene at 90℃; under 3750.38 Torr; for 4h; Autoclave; | A n/a B 99% |
carbon dioxide
p-aminoiodobenzene
methyloxirane
A
propylene glycol
Conditions | Yield |
---|---|
With C24H25N4O3(1+)*I(1-); 1,8-diazabicyclo[5.4.0]undec-7-ene at 90℃; under 3750.38 Torr; for 4h; Autoclave; | A n/a B 99% |
carbon dioxide
3,5-Dichloroaniline
methyloxirane
A
propylene glycol
Conditions | Yield |
---|---|
With C24H25N4O3(1+)*I(1-); 1,8-diazabicyclo[5.4.0]undec-7-ene at 90℃; under 3750.38 Torr; for 4h; Autoclave; | A n/a B 99% |
Conditions | Yield |
---|---|
With hydrogen In 1,4-dioxane at 179.84℃; under 7500.75 Torr; for 5h; Autoclave; | 98% |
With 5%-palladium/activated carbon; water; zinc at 250℃; for 0.5h; Reagent/catalyst; | 98% |
With 5% active carbon-supported ruthenium; water; zinc at 180℃; under 3750.38 Torr; for 20h; Autoclave; Inert atmosphere; | 82% |
Conditions | Yield |
---|---|
With trans-RuCl2(PPh3)[PyCH2NH(CH2)2PPh2]; potassium methanolate; hydrogen In tetrahydrofuran at 40℃; under 37503.8 Torr; for 16h; | 98% |
With C24H38Cl2N3PRu; hydrogen; sodium methylate In isopropyl alcohol at 100℃; under 38002.6 Torr; for 2h; Autoclave; | 97% |
With potassium tert-butylate; hydrogen; [tris(μ-chloro)bis((triphos)ruthenium(II))] chloride In methanol at 100℃; under 30003 Torr; for 15h; Product distribution / selectivity; Inert atmosphere; Autoclave; | >= 99.9 %Chromat. |
1,4-dihydroxybut-2-yne
A
propylene glycol
B
1-methylolallenephosphonous acid
Conditions | Yield |
---|---|
In 1,4-dioxane at 50℃; for 1h; | A 7.6 g B 97% |
carbon dioxide
aniline
methyloxirane
A
5-methyl-3-phenyl-oxazolidin-2-one
B
propylene glycol
Conditions | Yield |
---|---|
With C24H25N4O3(1+)*I(1-); 1,8-diazabicyclo[5.4.0]undec-7-ene at 90℃; under 3750.38 Torr; for 4h; Catalytic behavior; Reagent/catalyst; Temperature; Pressure; Autoclave; | A 95% B n/a |
Conditions | Yield |
---|---|
In isopropyl alcohol at 180℃; under 3750.38 Torr; for 24h; Inert atmosphere; Autoclave; | A 94% B 6% |
With water; hydrogen; alumina, 27%; copper, 5%; copper oxide, 64%; lanthanum oxide, 5%; mixture of In methanol at 297℃; under 37503.8 Torr; Product distribution / selectivity; | A 86.2% B 8.8% |
With Ru-Cu/TMG-BEN at 230℃; under 60006 Torr; for 18h; Autoclave; | A 85% B n/a |
carbon dioxide
methyloxirane
A
1,2-propylene cyclic carbonate
B
propylene glycol
Conditions | Yield |
---|---|
tetra-n-butylphosphonium chloride at 180℃; under 15001.5 - 37503.8 Torr; for 4h; Product distribution / selectivity; Gas phase; | A 0.3% B 93.4% |
tetraethylphosphonium bromide at 180℃; under 15001.5 - 37503.8 Torr; for 4h; Product distribution / selectivity; Gas phase; | A 0.5% B 92.7% |
With 1,8-diazabicyclo[5.4.0]undec-7-ene; cellulose at 120℃; under 15001.5 Torr; for 2h; Catalytic behavior; Reagent/catalyst; Temperature; Autoclave; Green chemistry; | A 90% B n/a |
propene
propylene glycol
Conditions | Yield |
---|---|
Stage #1: propene With Oxone; sodium chloride In water; acetone at 30℃; for 20h; Large scale; Stage #2: With water; sodium hydroxide at 25 - 40℃; for 7h; pH=12; Large scale; | 93% |
With osmium(VIII) oxide; dihydrogen peroxide; tert-butyl alcohol | |
With diphenylselenoxide; potassium carbonate; osmium(VIII) oxide In acetone for 24h; Ambient temperature; Phenylmethyl Selenoxide; | 95 % Chromat. |
Conditions | Yield |
---|---|
With sodium tetrahydroborate In methanol at 20℃; for 0.166667h; | 93% |
With carbonylhydrido(tetrahydroborato)[bis(2-diphenylphosphinoethyl)-amino]ruthenium(II); hydrogen; sodium t-butanolate In methanol at 80℃; under 37503.8 Torr; for 12h; Glovebox; Autoclave; chemoselective reaction; | 93% |
With (o-PPh2C6H4NH2)2RuCl2; hydrogen; sodium methylate In tetrahydrofuran at 120℃; under 37503.8 Torr; for 8h; Reagent/catalyst; | 98 %Chromat. |
carbon dioxide
4-Ethoxyaniline
methyloxirane
A
propylene glycol
Conditions | Yield |
---|---|
With C24H25N4O3(1+)*I(1-); 1,8-diazabicyclo[5.4.0]undec-7-ene at 90℃; under 3750.38 Torr; for 4h; Autoclave; | A n/a B 93% |
propene
A
propylene glycol
B
1-methoxy-2-propanol
C
2-methoxypropanol
D
methyloxirane
Conditions | Yield |
---|---|
With dihydrogen peroxide; titanium-silicate In methanol at 40℃; | A n/a B n/a C n/a D 92% |
With dihydrogen peroxide; titanium-silicate In methanol at 40℃; | A n/a B n/a C n/a D 78% |
With dihydrogen peroxide; titanium-silicate In water at 30 - 80℃; under 18751.9 Torr; pH=4.5; | A n/a B n/a C n/a D 61% |
Conditions | Yield |
---|---|
With ruthenium-carbon composite; hydrogen In water at 119.84℃; under 7500.75 - 60006 Torr; for 2h; Catalytic behavior; Reagent/catalyst; Autoclave; Sealed tube; | 92% |
With 5% active carbon-supported ruthenium; hydrogen at 130℃; under 26252.6 Torr; for 4h; Temperature; Autoclave; Inert atmosphere; | 61% |
Conditions | Yield |
---|---|
With [bis({2‐[bis(propan‐2‐yl)phosphanyl]ethyl})amine](bromo)(carbonyl)(hydride)iron(II); potassium tert-butylate; isopropyl alcohol In tetrahydrofuran at 140℃; for 6h; Time; Inert atmosphere; Schlenk technique; Green chemistry; | A 90 %Chromat. B 91% |
With potassium tert-butylate; hydrogen; C16H18BrCoINO2 In dibutyl ether at 160℃; under 45004.5 Torr; for 36h; Catalytic behavior; Solvent; | A 51 %Chromat. B 91% |
With [Mn(HN(C2H4PiPr2)2)(CO)2Br]; hydrogen; sodium t-butanolate In tetrahydrofuran at 120℃; under 22502.3 Torr; for 26h; Schlenk technique; Glovebox; Autoclave; | A 75% B 82% |
carbon dioxide
3-nitro-aniline
methyloxirane
A
propylene glycol
Conditions | Yield |
---|---|
With C24H25N4O3(1+)*I(1-); 1,8-diazabicyclo[5.4.0]undec-7-ene at 90℃; under 3750.38 Torr; for 4h; Autoclave; | A n/a B 91% |
Conditions | Yield |
---|---|
With phosphotungstic acid; dihydrogen peroxide at 70℃; for 4h; Reagent/catalyst; Temperature; | A 5.65% B 90.1% |
With [Fe(di(o-imidazol-2-ylidenepyridine)methane)(MeCN)2](PF6)2; dihydrogen peroxide In water; acetonitrile at 25℃; under 2850.29 Torr; for 3h; Catalytic behavior; Inert atmosphere; | A 64% B 11% |
With pyridine; carbon dioxide; dihydrogen peroxide; methyltrioxorhenium(VII) In water; acetonitrile at 25 - 40℃; under 36201.3 Torr; for 3h; | A n/a B 18.2% |
LACTIC ACID
propylene glycol
Conditions | Yield |
---|---|
With hydrogen In water at 150℃; under 30003 Torr; | 90% |
With copper(II) oxide; zinc In water at 250℃; for 2h; Reagent/catalyst; Green chemistry; | 63.8% |
With hydrogen at 110 - 150℃; under 60006 Torr; for 22h; Time; | 23.8% |
Conditions | Yield |
---|---|
In ethanol at 180℃; under 3750.38 Torr; for 24h; Inert atmosphere; Autoclave; | A 6% B 90% |
With hydrogen at 210℃; under 33753.4 Torr; for 12h; Catalytic behavior; Reagent/catalyst; Temperature; Pressure; | A n/a B 51.3% |
With hydrogen In 1,4-dioxane at 139.84℃; under 60006 Torr; for 24h; | A 34% B 18% |
propene
d,l-2-ethylhexanal
A
propylene glycol
B
2-Ethylhexanoic acid
Conditions | Yield |
---|---|
With sulfuric acid; water; oxygen In water at 60℃; under 2280.15 Torr; for 16h; pH=1; | A 36% B 90% |
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In methanol under 760 Torr; for 22h; Ambient temperature; | 89% |
With palladium on activated charcoal; diethyl ether Hydrogenation; | |
With hydrogen; Pd/magnetite In ethyl acetate at 23℃; under 760.051 Torr; for 5h; | |
With palladium 10% on activated carbon; hydrogen In neat (no solvent) at 80℃; under 6000.6 Torr; for 24h; Reagent/catalyst; Solvent; Temperature; Pressure; Time; Autoclave; | |
With palladium on activated carbon; hydrogen In ethanol at 20℃; under 2068.65 Torr; for 0.283333h; Flow reactor; |
carbon dioxide
1-amino-naphthalene
methyloxirane
A
propylene glycol
Conditions | Yield |
---|---|
With C24H25N4O3(1+)*I(1-); 1,8-diazabicyclo[5.4.0]undec-7-ene at 90℃; under 3750.38 Torr; for 4h; Autoclave; | A n/a B 89% |
1,2-propylene cyclic carbonate
A
propylene glycol
B
carbonic acid dimethyl ester
Conditions | Yield |
---|---|
With potassium carbonate In methanol at 119.84℃; for 2h; Temperature; Concentration; Autoclave; Industrial scale; | A n/a B 88% |
carbon dioxide
4-methoxy-aniline
methyloxirane
A
propylene glycol
B
3-(4-Methoxyphenyl)-5-methyl-2-oxazolidinone
Conditions | Yield |
---|---|
With C24H25N4O3(1+)*I(1-); 1,8-diazabicyclo[5.4.0]undec-7-ene at 90℃; under 3750.38 Torr; for 4h; Autoclave; | A n/a B 87% |
propylene glycol
4-nitrobenzaldehdye
4-methyl-2-(4-nitro-phenyl)-[1,3]dioxolane
Conditions | Yield |
---|---|
With cyclohexane at 105℃; for 1h; Dean-Stark; | 100% |
With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In ethyl acetate at 20℃; | 93% |
With toluene-4-sulfonic acid; benzene Unter Entfernen des entstehenden Wassers.; |
Conditions | Yield |
---|---|
With cyclohexane at 105℃; for 1h; Dean-Stark; | 100% |
With Amberlyst 36 at 50℃; for 2h; | 75% |
With 4 A molecular sieve; Amberlyst A 15 In tetrahydrofuran for 24h; Ambient temperature; | 35% |
propylene glycol
prednisolone hemisuccinate
Prednisolone 21-(2'-hydroxypropyl)succinate
Conditions | Yield |
---|---|
sulfuric acid for 2h; Heating; | 100% |
propylene glycol
N-formyl-1-bromo-narwedine
4a,5,9,10,11,12-hexhydro-1-bromo-3-methoxy-11-formyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-propylene ketal
Conditions | Yield |
---|---|
With toluene-4-sulfonic acid In toluene for 14h; Heating / reflux; | 100% |
89.5% |
propylene glycol
carbonic acid dimethyl ester
1,2-propylene cyclic carbonate
Conditions | Yield |
---|---|
at 120℃; for 7h; Product distribution / selectivity; Molecular sieve; | 100% |
In neat (no solvent) at 110℃; for 24h; Temperature; Molecular sieve; Green chemistry; | 99% |
With 1,1,1-trioctyl-1-methylphosphonium methylcarbonate at 90℃; for 1h; Catalytic behavior; Reagent/catalyst; | 96% |
propylene glycol
[Al2(OCH(CH3)2)2(CH3COCHCOCH3)2(OCH2CHCH3O)]2
Conditions | Yield |
---|---|
In benzene byproducts: i-PrOH; moisture free; refluxing; solvent removal; elem. anal.; | 100% |
Conditions | Yield |
---|---|
With Raney Ni In water at 179.84℃; for 1h; Inert atmosphere; Autoclave; | 100% |
Conditions | Yield |
---|---|
With cyclohexane at 105℃; for 1h; Dean-Stark; | 100% |
Conditions | Yield |
---|---|
With 5% CuO-5% PdO-0.5% Bi2O3-0.5% In2O3/modified γ-Al2O3 catalyst; 5% NiO-2% V2O5-0.4% Y2O3/modified γ-Al2O3 catalyst at 180℃; | 99.8% |
bei der elektrochemischen Oxydation; | |
With quinolinium monofluorochromate(VI) In dimethyl sulfoxide at 34.85℃; Kinetics; Thermodynamic data; Further Variations:; Solvents; Temperatures; Reagents; Oxidation; |
propylene glycol
4-oxopentanoic acid ethyl ester
2,4-dimethyl-1,3-dioxolane-2-propionic acid ethyl ester
Conditions | Yield |
---|---|
sulfuric acid In water at 95 - 106℃; under 30 - 80 Torr; Product distribution / selectivity; | 99.8% |
With sulfuric acid at 110 - 170℃; under 10 - 15 Torr; |
Conditions | Yield |
---|---|
With cyclohexane at 105℃; for 1h; Dean-Stark; | 99.7% |
With phosphorus modified SO4(2-)/TiO2 In cyclohexane for 2h; Dean-Stark; Reflux; | 98% |
With poly(styren-co-3-(1-vinyllimidazolium-3-yl)propane-1-sulfonate)-acid at 110℃; for 1.5h; Reagent/catalyst; | 96.2% |
Conditions | Yield |
---|---|
With phosphorus modified SO4(2-)/TiO2 In cyclohexane for 2h; Dean-Stark; Reflux; | 99% |
With salicylic acid resin supported FeCl3 In benzene at 88 - 96℃; for 2h; | 98.5% |
With cyclohexane at 105℃; for 1h; Dean-Stark; | 94.6% |
Conditions | Yield |
---|---|
With phosphorus modified SO4(2-)/TiO2 In cyclohexane for 2h; Dean-Stark; Reflux; | 99% |
for 2h; Reflux; | 88.6% |
With formylmorpholine-dimethylsulfate-adduct In dichloromethane for 24h; Ambient temperature; | 72.7% |
propylene glycol
tert-butylchlorodiphenylsilane
1-((tert-butyldiphenylsilyl)oxy)propan-2-ol
Conditions | Yield |
---|---|
With 1H-imidazole In DMF (N,N-dimethyl-formamide) at 20℃; for 2h; | 99% |
propylene glycol
[Ti(N-phenylsalicylideneimine(-H))2(OCH2CH(CH3)O)]
Conditions | Yield |
---|---|
In benzene byproducts: (CH3)2CHOH; under unhydrous atm., soln. of ligand added to soln. of Ti compd. (3.06:3.01), refluxed, monitored by isopropanol liberated; concd., crystd., elem. anal.; | 99% |
2-chloroethanal
propylene glycol
4-methyl-1,3-dioxolan-2-ylmethyl chloride
Conditions | Yield |
---|---|
With phosphorus modified SO4(2-)/TiO2 In cyclohexane for 2h; Dean-Stark; Reflux; | 99% |
With C13H16NO3S(1+)*0.5Cu(2+)*O4S(2-) In cyclohexane for 0.5h; Reflux; | 99 %Chromat. |
With solid acidic polymeric ionic liquid from [SO3H(CH2)3VIm]HSO4 and resorcinol-formaldehyde resin In cyclohexane for 0.5h; Reflux; Dean-Stark; | 99 %Chromat. |
Conditions | Yield |
---|---|
With 2-Cyanopyridine; cerium(IV) oxide at 139.84℃; under 37503.8 Torr; for 1h; Temperature; Autoclave; | 99% |
With 1,10-Phenanthroline; calcium carbide; zinc trifluoromethanesulfonate In 1-methyl-pyrrolidin-2-one at 180℃; under 37503.8 Torr; for 24h; Autoclave; Glovebox; Sealed tube; | 92% |
With potassium carbonate; (S)-propyleneoxide at 120℃; under 30003 Torr; for 10h; Reagent/catalyst; Pressure; Time; Autoclave; Green chemistry; | 78% |
propylene glycol
Conditions | Yield |
---|---|
With magnesium sulfate In toluene at 100℃; for 2h; | 99% |
Conditions | Yield |
---|---|
Stage #1: 1,4-diaza-bicyclo[2.2.2]octane; zinc(II) nitrate hexahydrate; isophthalic acid In N,N-dimethyl-formamide for 1h; Stage #2: propylene glycol In N,N-dimethyl-formamide at 130℃; for 48h; | 99% |
propylene glycol
octadecyldimethyl[3-(trimethoxysilyl)propyl]ammonium chloride
Conditions | Yield |
---|---|
In N,N-dimethyl-formamide at 145℃; | 99% |
Conditions | Yield |
---|---|
With salicylic acid resin supported FeCl3 In benzene at 88 - 92℃; for 2h; | 98.9% |
With 4 A molecular sieve; Amberlyst A 15 In tetrahydrofuran for 24h; Ambient temperature; | 71% |
With formylmorpholine-dimethylsulfate-adduct In dichloromethane for 24h; Ambient temperature; | 61.8% |
propylene glycol
4-chlorobenzaldehyde
2-(4-chloro-phenyl)-4-methyl-[1,3]dioxolane
Conditions | Yield |
---|---|
With cyclohexane at 105℃; for 1h; Dean-Stark; | 98.6% |
With toluene-4-sulfonic acid; benzene Unter Entfernen des entstehenden Wassers.; | |
Al-Fe pillared montmorillonite clay In dichloromethane at 25℃; for 8h; | 100 % Turnov. |
With 1-hexyl-3-methylimidazolium tetrafluoroborate at 130℃; for 3h; |
1,2-Propanediol (CAS NO.57-55-6 ), also known as Propylene glycol, is a colorless, odorless, viscous, highly hygroscopic liquid with a faintly sweet taste. It is miscible with water, ethanol, ether, chloroform, acetone and other organic solvents. The solubility to hydrocarbons and chlorinated hydrocarbons is small, but it is strong than ethylene glycol. Propylene Glycol contains an asymmetrical carbon atom, so it exists in two optically active forms (dextrorotatory and sinistrorotatory isomers). And the commercial Propylene Glycol is a racemic mixture.
Physical properties about Propylene Glycol are: (1)ACD/LogP: -1.341; (2)ACD/LogD (pH 5.5): -1.34; (3)ACD/LogD (pH 7.4): -1.34; (4)ACD/BCF (pH 5.5): 1.00; (5)ACD/BCF (pH 7.4): 1.00; (6)ACD/KOC (pH 5.5): 4.44; (7)ACD/KOC (pH 7.4): 4.44; (8)#H bond acceptors: 2; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 3; (11)Index of Refraction: 1.43; (12)Molar Refractivity: 18.976 cm3; (13)Molar Volume: 73.444 cm3; (14)Polarizability: 7.523 10-24cm3; (15)Surface Tension: 38.0040016174316 dyne/cm; (16)Density: 1.036 g/cm3; (17)Flash Point: 107.222 °C; (18)Enthalpy of Vaporization: 49.011 kJ/mol; (19)Boiling Point: 184.848 °C at 760 mmHg; (20)Vapour Pressure: 0.203999996185303 mmHg at 25°C
Preparation of Propylene Glycol: Propylene Glycol can be obtaine by epoxypropane. It includes direct hydration and indirect hydration. The direct hydration is the reaction of epoxypropane and water at 150-160 °C and 0.78-0 .98 MPa. After evaporation and distillation, Propylene Glycol is obtained. The indirect hydration is the reaction of epoxypropane and water in the presence of catalyst sulfuric acid. In addition, Propylene Glycol also can be produced by direct catalytic oxidation from propylene. The catalyst is anhydrous tertiary butanol.
Uses of Propylene Glycol: Propylene Glycol is an important raw material in unsaturated polyester, epoxy resins, polyurethane resins, plasticizers and surfactants. The amount occupies about 45% of total consumption. This unsaturated polyester is largely used for surface coatings and reinforced plastics. Because of good viscosity and moisture absorption, and non-toxic, Propylene Glycol is widely used as a hygroscopic agent, antifreeze, lubricants and solvents in the food, pharmaceutical and cosmetics industries. In the food industry, Propylene Glycol and fatty acid reacts to produce propylene glycol ester of fatty acid, which is mainly used as food emulsifier. It is also used as solvent for spices, seasonings and food coloring. What's more, 1,2-propanediol is used as a humidifying agent of tobacco, mildew preventive, fruit ripening preservatives, film-forming coatings additives, antifreeze and heat transfer media, etc. It is often used as a substitute for ethanol and glycerol. In pharmaceutical industry, Propylene Glycol is commonly used as solvent in the manufacture of various types of ointment, softener, excipients, preservatives, vitamins, penicillin, etc. As Propylene Glycol has good solubility with various spices, it is also used as solvent of cosmetic and softeners, etc.
When you are using this chemical, please be cautious about it as the following: The Propylene Glycol is low toxicity. So the acute oral toxicity is very low, and large quantities are required to cause perceptible health damage in humans. In the human body, Propylene Glycol is metabolized into pyruvic acid (a normal part of the glucose-metabolism process, readily converted to energy), lactic acid (a normal acid generally abundant during digestion), acetic acid (handled by ethanol-metabolism), and propionaldehyde. So you should avoid contact with skin and eyes.
You can still convert the following datas into molecular structure:
1. Smiles:C([C@@H](C)O)O;
2. InChI:InChI=1/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3;
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
chicken | LDLo | intravenous | 27gm/kg (27000mg/kg) | VASCULAR: OTHER CHANGES | Journal of Pharmacology and Experimental Therapeutics. Vol. 60, Pg. 312, 1937. |
child | TDLo | oral | 79gm/kg/56W-I (79000mg/kg) | BRAIN AND COVERINGS: CHANGES IN SURFACE EEG BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Pediatrics. Vol. 93, Pg. 515, 1978. |
dog | LD50 | intravenous | 26gm/kg (26000mg/kg) | National Technical Information Service. Vol. PB280-477, | |
dog | LD50 | oral | 22gm/kg (22000mg/kg) | Journal of Industrial Hygiene and Toxicology. Vol. 21, Pg. 173, 1939. | |
guinea pig | LD50 | oral | 18350mg/kg (18350mg/kg) | Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941. | |
guinea pig | LDLo | subcutaneous | 15500mg/kg (15500mg/kg) | National Technical Information Service. Vol. PB280-477, | |
infant | TDLo | parenteral | 10gm/kg/3D-C (10000mg/kg) | Pediatrics. Vol. 72, Pg. 353, 1983. | |
mouse | LD50 | intraperitoneal | 9718mg/kg (9718mg/kg) | LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI BLOOD: CHANGES IN SPLEEN | Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 6, Pg. 342, 1947. |
mouse | LD50 | intravenous | 6630mg/kg (6630mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976. | |
mouse | LD50 | oral | 22gm/kg (22000mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 65, Pg. 89, 1939. | |
mouse | LD50 | subcutaneous | 17370mg/kg (17370mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Kriobiologiya i Kriomeditsina. Cryobiology and Cryomedicine. Vol. 8, Pg. 46, 1981. |
quail | LD50 | oral | > 2080mg/kg (2080mg/kg) | Ecotoxicology and Environmental Safety. Vol. 6, Pg. 149, 1982. | |
rabbit | LD50 | intravenous | 6500mg/kg (6500mg/kg) | National Technical Information Service. Vol. PB280-477, | |
rabbit | LD50 | oral | 18500mg/kg (18500mg/kg) | FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 491, 1974. | |
rabbit | LD50 | skin | 20800mg/kg (20800mg/kg) | Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 101, 1974. | |
rabbit | LDLo | intramuscular | 6300mg/kg (6300mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: COMA | Journal of Pharmacology and Experimental Therapeutics. Vol. 44, Pg. 109, 1932. |
rat | LD50 | intramuscular | 14gm/kg (14000mg/kg) | Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974, | |
rat | LD50 | intraperitoneal | 6660mg/kg (6660mg/kg) | Kriobiologiya i Kriomeditsina. Cryobiology and Cryomedicine. Vol. 9, Pg. 36, 1981. | |
rat | LD50 | intravenous | 6423mg/kg (6423mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976. | |
rat | LD50 | oral | 20gm/kg (20000mg/kg) | Toxicology and Applied Pharmacology. Vol. 45, Pg. 362, 1978. | |
rat | LD50 | subcutaneous | 22500mg/kg (22500mg/kg) | Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974, |
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