1,3-Dimethylurea supplier

Name
1,3-Dimethylurea
EINECS 202-498-7
CAS No. 96-31-1
Article Data79
CAS DataBase
Density 0.949 g/cm³
Solubility 765 g/L (21.5 °C) in water
Melting Point 101-104 °C(lit.)
Formula C₃H₈N₂O
Boiling Point 269 °C at 760 mmHg
Molecular Weight 88.1093
Flash Point 124.3 °C
Transport Information
Appearance white flake
Safety 22-24/25
Risk Codes 62-63-68
Molecular Structure
Hazard Symbols
Synonyms Urea,1,3-dimethyl- (8CI);N,N'-Dimethylurea;NSC 14910;NSC 24823;Symmetric dimethylurea;sym-Dimethylurea;
PSA 41.13000
LogP 0.32700

Synthetic route

: 868-84-8
S,S-dimethyl dithiocarbonate

: 74-89-5
methylamine

: 96-31-1
N,N'-Dimethylurea

Conditions

Conditions	Yield
In water at 60℃; for 2h;	97%

: 130749-94-9
1,3-Dimethyl-5-(1-phenyl-ethyl)-[1,3,5]triazinan-2-one

A: 96-31-1
N,N'-Dimethylurea

B: 618-36-0
rac-methylbenzylamine

Conditions

Conditions	Yield
With ammonium chloride at 70℃; for 3h; other hexahydro-2-oxo-1,3,5-triazines;	A n/a B 90%

: 124-41-4
sodium methylate

: 80981-25-5
1,3-Dimethyl-1-(1H-pyrazole-4-carbonyl)-urea

A: 51105-90-9
methyl pyrazole-4-carboxylate

B: 96-31-1
N,N'-Dimethylurea

Conditions

Conditions	Yield
In methanol for 2h; Heating;	A 79% B 83%

...Expand

: 80981-25-5
1,3-Dimethyl-1-(1H-pyrazole-4-carbonyl)-urea

A: 51105-90-9
methyl pyrazole-4-carboxylate

B: 96-31-1
N,N'-Dimethylurea

Conditions

Conditions	Yield
With sodium methylate In methanol for 2h; Heating;	A 79% B 83%

: 121-39-1
ethyl 3-phenylglycidate

: 534-13-4
N,N-dimethylthiourea

A: 96-31-1
N,N'-Dimethylurea

B: (Z)-N-methyl-N-(methylcarbamoyl)-3-phenylacrylamide

C: (E)-N-methyl-N-(methylcarbamoyl)-3-phenylacrylamide

Conditions

Conditions	Yield
With ytterbium(III) triflate In 1,4-dioxane at 90℃; for 8h; Schlenk technique; Inert atmosphere; Sealed tube;	A n/a B 8% C 80%

...Expand

: 49785-67-3
1,3-dimethyl-4-thiouracil

: 6642-31-5
6-Amino-1,3-dimethylbarbituric acid

A: 96-31-1
N,N'-Dimethylurea

B: 74115-57-4
1,3-dimethyl-7-mercaptopyrido<2,3-d>pyrimidine-2,4-(1H,3H)-dione

Conditions

Conditions	Yield
With sodium ethanolate In ethanol	A n/a B 78%

...Expand

: 868-59-7
L-cysteine ethyl ester hydrochloride

: 1-(tert-butylimino-methyl)-1,3-dimethylurea hydrochloride

A: 96-31-1
N,N'-Dimethylurea

B: 206876-90-6
ethyl (R)-4,5-dihydrothiazole-4-carboxylate

Conditions

Conditions	Yield
With triethylamine In dichloromethane Heating;	A n/a B 78%

...Expand

: 534-13-4
N,N-dimethylthiourea

: 134-81-6
benzil

A: 96-31-1
N,N'-Dimethylurea

B: 137514-25-1
1,3,4,6-Tetramethyl-3a,6a-diphenyl-5-thioxo-hexahydro-imidazo[4,5-d]imidazol-2-one

C: 16459-85-1
1,3-dimethyl-4,5-diphenyl-5-imidazoline-2-thioneN,N-dimethyl-4-oxo-4H-chromene-2-carboxamide

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 4h; Mechanism; Heating; other substrates;	A n/a B n/a C 71%
With hydrogenchloride In ethanol for 4h; Heating;	A n/a B n/a C 71%

...Expand

: 4869-46-9
1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde

: 93-91-4
1-phenylbutan-1,3-dione

A: 96-31-1
N,N'-Dimethylurea

B: 3-benzoyl-4-hydroxy-N-methylbenzamide

Conditions

Conditions	Yield
With potassium carbonate; tetra(n-butyl)ammonium hydrogensulfate In N,N-dimethyl-formamide at 20℃;	A 6% B 70%

...Expand

: 6642-31-5
6-Amino-1,3-dimethylbarbituric acid

: 36980-95-7
5-(1,3-Dimethyl-2,4-dioxopyrimidil)methyl ketone

A: 96-31-1
N,N'-Dimethylurea

B: 74115-56-3
6-Acetyl-1,3-dimethyl-1H,8H-pyrido[2,3-d]pyrimidine-2,4,7-trione

Conditions

Conditions	Yield
With potassium hydroxide In ethanol for 9h; Heating;	A n/a B 65%

...Expand

: 41740-15-2
6-amino-1,3-diethyluracil

: 36980-91-3
1,3-dimethyl-5-cyanouracil

A: 96-31-1
N,N'-Dimethylurea

B: 74115-53-0
1,3-Diethyl-2,4,7-trioxo-1,2,3,4,7,8-hexahydro-pyrido[2,3-d]pyrimidine-6-carbonitrile

Conditions

Conditions	Yield
With sodium ethanolate In ethanol for 1h; Heating;	A n/a B 65%

...Expand

: 74124-79-1
di(succinimido) carbonate

: 74-89-5
methylamine

A: 18342-66-0
2,5-dioxopyrrolidin-1-yl methylcarbamate

B: 96-31-1
N,N'-Dimethylurea

Conditions

Conditions	Yield
In acetonitrile Ambient temperature;	A 63.1% B n/a

...Expand

: 6642-31-5
6-Amino-1,3-dimethylbarbituric acid

: 36980-91-3
1,3-dimethyl-5-cyanouracil

A: 96-31-1
N,N'-Dimethylurea

B: 74115-52-9
6-cyano-1,3-dimethylpyrido<2,3-d>pyrimidine-2,4,7-(1H,3H,8H)-trione

Conditions

Conditions	Yield
With potassium hydroxide In ethanol for 4h; Heating;	A n/a B 63%

...Expand

: 41862-14-0
6-amino-1,3-dipropyluracil

: 36980-91-3
1,3-dimethyl-5-cyanouracil

A: 96-31-1
N,N'-Dimethylurea

B: 74115-54-1
2,4,7-Trioxo-1,3-dipropyl-1,2,3,4,7,8-hexahydro-pyrido[2,3-d]pyrimidine-6-carbonitrile

Conditions

Conditions	Yield
With sodium ethanolate In ethanol for 2h; Heating;	A n/a B 63%

...Expand

: 79645-01-5
N1,N3-dimethyl-N1-nitrosothiourea

: 96-31-1
N,N'-Dimethylurea

Conditions

Conditions	Yield
With hydrogenchloride In diethyl ether for 0.5h;	62%
With hydrogenchloride; water 1) ether, 2) ether; Yield given. Multistep reaction;

: 141-52-6
sodium ethanolate

: 4869-46-9
1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde

: 123-54-6
acetylacetone

A: 96-31-1
N,N'-Dimethylurea

B: 57009-53-7
ethyl 3-acetyl-4-hydroxybenzoate

Conditions

Conditions	Yield
In ethanol for 2h; Mechanism; Heating; other 1,3-ambident nucleophiles. Object of study: a novel ring transformation;	A n/a B 55%
In ethanol for 2h; Heating;	A n/a B 55%

...Expand

: 4869-46-9
1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde

: 123-54-6
acetylacetone

A: 96-31-1
N,N'-Dimethylurea

B: 57009-53-7
ethyl 3-acetyl-4-hydroxybenzoate

Conditions

Conditions	Yield
With sodium ethanolate In ethanol for 2h; Heating; Yield given;	A n/a B 55%
With sodium ethanolate In ethanol for 2h; Heating; Yield given;

...Expand

: 6642-31-5
6-Amino-1,3-dimethylbarbituric acid

: 41613-26-7
1,3-dimethyl-5-nitrouracil

A: 96-31-1
N,N'-Dimethylurea

B: 74115-55-2
6-nitropyridopyrimidine

Conditions

Conditions	Yield
With potassium hydroxide In ethanol for 3h; Heating;	A n/a B 50%

...Expand

: 74-89-5
methylamine

polycarbonate: polycarbonate

A: 80-05-7
BPA

B: 96-31-1
N,N'-Dimethylurea

Conditions

Conditions	Yield
In ethanol; water at 80℃; for 12h; Green chemistry;	A n/a B 50%

...Expand

: 67-56-1
methanol

: 3,4-dihydro-3,5,6-trimethyl-2,4-dioxo-2H-1,3,5-oxadiazinium hexachloroantimonate

A: 96-31-1
N,N'-Dimethylurea

B: 1,1-dimethoxyethylium hexachloroantimonate

Conditions

Conditions	Yield
In dichloromethane at 23℃; for 2h;	A n/a B 48%

...Expand

: 1215225-05-0
1,8-bis(1,3-dimethyluracil-6-yl)-cyclam

A: 96-31-1
N,N'-Dimethylurea

B: 11-(1,3-dimethyluracil-6-yl)-1,4,8,11-tetraaza-17-oxo-tricyclo[6.6.3.0(4,15)]heptadecanium perchlorate

Conditions

Conditions	Yield
With zinc(II) perchlorate In dimethyl sulfoxide at 120℃; for 1h;	A n/a B 44.2%

: 4869-46-9
1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde

: 123-54-6
acetylacetone

A: 96-31-1
N,N'-Dimethylurea

B: 3-acetyl-4-hydroxy-N-methylbenzamide

C: 1-(3-acetyl-4-hydroxybenzoyl)-1,3-dimethylurea

D: 6-acetyl-7-hydroxy-1,3-dimethylquinazoline-2,4(1H,3H)-dione

Conditions

Conditions	Yield
With potassium carbonate; tetra(n-butyl)ammonium hydrogensulfate In N,N-dimethyl-formamide at 20℃;	A 4% B 15% C 36% D 14%

...Expand

: 141-97-9
ethyl acetoacetate

: 4869-46-9
1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde

A: 96-31-1
N,N'-Dimethylurea

B: 74442-97-0
3-(Ethoxycarbonyl)-4-hydroxy-N-methylbenzamide

C: 6-ethoxycarbonyl-7-hydroxy-1,3-dimethylquinazoline-2,4(1H,3H)-dione

Conditions

Conditions	Yield
With potassium carbonate; tetra(n-butyl)ammonium hydrogensulfate In N,N-dimethyl-formamide at 20℃;	A 9% B 20% C 34%

...Expand

: 874-14-6
1,3-dimethyluracil

: 6642-31-5
6-Amino-1,3-dimethylbarbituric acid

A: 96-31-1
N,N'-Dimethylurea

B: 57821-20-2
1,3-dimethylpyrido<2,3-d>pyrimidine-2,4,7(1H,3H,8H)-trione

Conditions

Conditions	Yield
With sodium ethanolate In ethanol for 95h; Heating;	A n/a B 33%

...Expand

: 75-52-5
nitromethane

: 201230-82-2
carbon monoxide

: 74-89-5
methylamine

: 96-31-1
N,N'-Dimethylurea

Conditions

Conditions	Yield
With iron(III) chloride In methanol; N,N-dimethyl-formamide at 75℃; under 4137.29 Torr; for 6h; Catalytic behavior; Autoclave;	32%
Stage #1: nitromethane; methylamine In methanol; N,N-dimethyl-formamide for 0.166667h; Stage #2: carbon monoxide With iron(III) chloride In methanol; N,N-dimethyl-formamide at 90℃; under 3040.2 Torr; for 5h; Autoclave;	28%

...Expand

: 140-95-4
1,3-bis(hydroxymethyl)urea

: 96-31-1
N,N'-Dimethylurea

Conditions

Conditions	Yield
With hydrogenchloride; amalgamated zinc

: 141-07-1
N,N'-bis(methoxymethyl)urea

: 96-31-1
N,N'-Dimethylurea

Conditions

Conditions	Yield
With nickel at 100℃; under 51485.6 - 102971 Torr; Hydrogenation;

: 65398-48-3
methylammonium N-methylcarbamate

: 96-31-1
N,N'-Dimethylurea

Conditions

Conditions	Yield
at 170℃;

: 624-83-9
methyl isocyanate

: 74-89-5
methylamine

: 96-31-1
N,N'-Dimethylurea

: 624-83-9
methyl isocyanate

: 96-31-1
N,N'-Dimethylurea

Conditions

Conditions	Yield
With water
With water at 100℃;

: 96-31-1
N,N'-Dimethylurea

: 485-47-2
indan-1,2,3-trione hydrate

: 22431-02-3
3a,8a-dihydroxy-1,3-dimethyl-1,3,3a,8a-tetrahydroindeno[1,2-d]imidazole-2,8-dione

Conditions

Conditions	Yield
at 20℃; for 2h;	100%
In water at 50 - 60℃;	82%

: 96-31-1
N,N'-Dimethylurea

: 24776-91-8
N-chloro-N,N'-dimethylurea

Conditions

Conditions	Yield
With sodium hypochlorite In water Product distribution / selectivity;	100%
With water; sodium chloride at 20℃; for 0.5h; Reagent/catalyst; pH-value; Concentration; Electrolysis;	89%

: 96-31-1
N,N'-Dimethylurea

: 298-12-4
Glyoxilic acid

: 64732-10-1
5-hydroxy-1,3-dimethylimidazolidine-2,4-dione

Conditions

Conditions	Yield
In ethyl acetate Solvent;	100%

: 96-31-1
N,N'-Dimethylurea

: 25466-50-6
N,N'-dimethyl-N,N'-dinitrourea

Conditions

Conditions	Yield
With dinitrogen pentoxide In carbon dioxide at 0 - 5℃; under 45004.5 - 60006 Torr; for 0.5h; Time; liquid CO2;	99%

: 96-31-1
N,N'-Dimethylurea

: 4112-03-2
N-methylsulfamic acid

Conditions

Conditions	Yield
With sulfuric acid; sulfur trioxide In 1,2-dichloro-ethane Product distribution; 1.) r.t., 15 min; 2.) 70-80 deg C; effect of oleum concentration in different solvents, influence of the temperature of dissolution of sulfuric acid, influence of reaction temperature on the yield;	98%
With sulfuric acid; sulfur trioxide In 1,2-dichloro-ethane 1.) 15 min, r.t.; 2.) 70-80 deg C, 6-8 h;	98%
With sulfuric acid; sulfur trioxide

: 96-31-1
N,N'-Dimethylurea

: 4614-90-8
Diphenylamino-phosphordichlorid

: 126695-44-1
1,3-dimethyl-2-diphenylamino-1,3-diaza-2λ3-phosphetidin-4-on

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran for 12h; Ambient temperature;	98%

: 96-31-1
N,N'-Dimethylurea

: 13256-32-1
1,3 dimethyl 1 nitrosourea

Conditions

Conditions	Yield
With hydrogenchloride; sodium nitrite In water at 0℃; for 1h;	98%
With sulfuric acid; sodium nitrite In water cooling;	58%
With cis-nitrous acid In 1,4-dioxane; water Rate constant; variation of H2O/dioxane ratio, addition of acids or salts;

: 50-00-0
formaldehyd

: 96-31-1
N,N'-Dimethylurea

: 618-36-0
rac-methylbenzylamine

: 130749-94-9
1,3-Dimethyl-5-(1-phenyl-ethyl)-[1,3,5]triazinan-2-one

Conditions

Conditions	Yield
In water at 70 - 110℃;	98%

...Expand

: 109-09-1
2-chloropyridine

: 96-31-1
N,N'-Dimethylurea

: N,N'-dimethyl-N-(pyridin-2-yl)urea

Conditions

Conditions	Yield
With 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; sodium t-butanolate; palladium diacetate In 1,4-dioxane at 100℃; for 2h;	98%

: 96-31-1
N,N'-Dimethylurea

: 119072-55-8, 7188-38-7
tert-butylisonitrile

: 762-42-5
dimethyl acetylenedicarboxylate

: methyl trans-5-[(tert-butylamino)carbonyl]-1,3-dimethyl-2,6-dioxo-hexahydro-pyrimidine-4-carboxylate

Conditions

Conditions	Yield
With D-glucose In water at -5 - 20℃;	98%

...Expand

: 3262-89-3
triphenylboroxine

: 96-31-1
N,N'-Dimethylurea

: 1201-45-2
Bis-(dimethylamino)-phenylboran

: 81233-30-9
O(μ-C6H5BNCH3)2CO

Conditions

Conditions	Yield
In toluene byproducts: (CH3)2NH; under inert atm., mixt. of (C6H5BO)3 and ((CH3)2N)2BC6H5 heated for 90 min to 125°C, cooled to room temp., addn. of toluene and (NHCH3)2CO, stirred mixt. heated to reflux for 4 days; evapn., distd. under vac., sublimation, slowly crystn. on standing; elem. anal.;	98%

...Expand

: 96-31-1
N,N'-Dimethylurea

: 65-85-0
benzoic acid

: 88070-48-8
N-methylbenzamide

Conditions

Conditions	Yield
With zirconyl chloride octahydrate for 0.05h; Irradiation;	98%
With 1H-imidazole In octane at 130℃; for 24h;

: 108-05-4
vinyl acetate

: 96-31-1
N,N'-Dimethylurea

: 542-08-5
isopropyl acetoacetate

: isopropyl 1,3,4,6-tetramethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Conditions

Conditions	Yield
With isopropyl alcohol In water at 60℃; for 48h; Biginelli Pyrimidone Synthesis; Enzymatic reaction;	98%

...Expand

: 13987-61-6
N-methylene-tert-butylamine

: 96-31-1
N,N'-Dimethylurea

: 65282-91-9
5-tert-Butyl-1,3-dimethyl-[1,3,5]triazinan-2-one

Conditions

Conditions	Yield
for 4h; Heating;	97%

: 302-17-0
chloral hydrate

: 96-31-1
N,N'-Dimethylurea

: 1-methyl-1-(1-hydroxy-2,2,2-trichloroethyl)-3-methyl urea

Conditions

Conditions	Yield
With 3 A molecular sieve In 1,4-dioxane at 70℃; for 168h; Substitution;	97%

: 96-31-1
N,N'-Dimethylurea

: phosphorochloridous acid bis-(2,4-di-tert-butyl-phenyl) ester; compound with hexane

: P(OC6H3Bu(t)2-2,4)2N(Me)CON(Me)H

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran for 4h;	97%

: (pentacarbonyl)(phenylethynyl)(ethoxy)carbene chromium(0)

: 96-31-1
N,N'-Dimethylurea

: 206069-47-8
[Cr(CO)5(C4HN2O(C6H5)(CH3)2)]

Conditions

Conditions	Yield
In tetrahydrofuran heating of (CO)5Cr(C(CCPh)OCH2CH3) and HNMeCONHMe (2 equiv.) at 60°C in THF with stirring (Organometallics 17 (1998) 2135); cooling to room temp.; evapn. of solvent in vac., flash chromy.;	97%
In tetrahydrofuran Ar-atmosphere; room temp. (48 h);	70%

: 108-05-4
vinyl acetate

: 96-31-1
N,N'-Dimethylurea

: 7779-75-1
isobutyl acetoacetate

: isobutyl 1,3,4,6-tetramethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Conditions

Conditions	Yield
With isopropyl alcohol In water at 60℃; for 48h; Biginelli Pyrimidone Synthesis; Enzymatic reaction;	97%

...Expand

: 96-31-1
N,N'-Dimethylurea

: 141-97-9
ethyl acetoacetate

: 100-52-7
benzaldehyde

: 67092-74-4
1,3,6-trimethyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With ammonium cerium (IV) nitrate In neat (no solvent) at 80℃; for 0.025h; Catalytic behavior; Reagent/catalyst; Solvent; Microwave irradiation;	96%
With chloro-trimethyl-silane In N,N-dimethyl-formamide	79%
With hafnium tetrakis(trifluoromethanesulfonate) In neat (no solvent) at 80℃; Biginelli Pyrimidone Synthesis;	68%
Dowex-50W at 130℃; Biginelli condensation;	59%

...Expand

: 96-31-1
N,N'-Dimethylurea

: 603-11-2
3-nitrophthalic acid

: Ethyl S-(acetylamino)-1,2,3,4-tetrahydro-2-methyl-7-nitro-8-isoquinolinepropanoate

Conditions

Conditions	Yield
In ethanol	96%

: 96-31-1
N,N'-Dimethylurea

: 108-24-7
acetic anhydride

: 372-09-8
cyanoacetic acid

: 6642-31-5
6-Amino-1,3-dimethylbarbituric acid

Conditions

Conditions	Yield
at 60℃; for 3h;	96%

...Expand

: 39755-95-8
5-methoxyisatine

: 96-31-1
N,N'-Dimethylurea

: 104-15-4
toluene-4-sulfonic acid

: 2-(4-hydroxy-1,3-dimethyl-2,5-dioxoimidazolidin-4-yl)-4-methoxybenzenaminium 4-methylbenzenesulfonate

Conditions

Conditions	Yield
In acetonitrile at 80℃; for 3h;	96%

...Expand

: 96-31-1
N,N'-Dimethylurea

: 117-34-0
2,2-diphenylacetic acid

: 954-21-2
N-methyldiphenylacetamide

Conditions

Conditions	Yield
With magnesium(II) nitrate hexahydrate In octane at 130℃; for 24h; Reagent/catalyst;	96%

: 96-31-1
N,N'-Dimethylurea

: 18522-92-4
sodium p-toluenesulfonamide

A: 13909-69-8
N-Methyl-N'-toluene-p-sulfonylurea

B: 74-89-5
methylamine

Conditions

Conditions	Yield
at 160℃; for 3h; Product distribution; Rate constant; Equilibrium constant; Other temperature, other time, other ratio of reactants, activation energy, ΔH, ΔS;;	A 95.5% B n/a
at 160℃; for 3h;	A 95.5% B n/a

...Expand

: 50-00-0
formaldehyd

: 96-31-1
N,N'-Dimethylurea

: 931-15-7, 931-16-8, 6850-38-0, 6982-39-4, 33092-82-9, 38898-70-3, 74111-21-0, 108267-20-5
(1R,2R)-2-aminocyclohexanol

: 130750-04-8
5-((1R,2R)-2-Hydroxy-cyclohexyl)-1,3-dimethyl-[1,3,5]triazinan-2-one

Conditions

Conditions	Yield
In water at 70 - 110℃;	95%

...Expand

: 96-31-1
N,N'-Dimethylurea

: 98-46-4
3-trifluoromethylnitrobenzene

: 54672-10-5
N-methyl-4-nitro-2-trifluoromethylaniline

Conditions

Conditions	Yield
With sodium hydroxide In dimethyl sulfoxide	95%

: 96-31-1
N,N'-Dimethylurea

: 3740-18-9
2,4-dichloro-5-(chlorosulfonyl)benzoic acid

: 89894-62-2
2,4-dichloro-5-chlorosulfonylbenzoic acid N-methylamide

Conditions

Conditions	Yield
at 90℃;	95%

: 104-01-8
4-Methoxyphenylacetic acid

: 96-31-1
N,N'-Dimethylurea

: 59907-36-7
2-(4-methoxyphenyl)-N-methylacetamide

Conditions

Conditions	Yield
With 1H-imidazole In octane at 130℃; for 24h; Reagent/catalyst;	95%

: 1878-66-6
4-chlorophenylacetic Acid

: 96-31-1
N,N'-Dimethylurea

: 60336-41-6
2-(4-chlorophenyl)-N-methylacetamide

Conditions

Conditions	Yield
With magnesium(II) nitrate hexahydrate In octane at 130℃; for 24h; Reagent/catalyst;	95%

1,3-Dimethylurea Consensus Reports

1,3-Dimethylurea (CAS NO.96-31-1) is reported in EPA TSCA Inventory.

1,3-Dimethylurea Specification

The 1,3-Dimethylurea, with CAS number of 96-31-1, can be called N,N'-Dimethylharnstoff ; N,N'-Dimethylurea ; Symmetric dimethylurea ; sym-Dimethylurea . It is a white crystal, 1,3-Dimethylurea (CAS NO.96-31-1) is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P₂O₅ or SOCl₂ generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Properties of 1,3-Dimethylurea：
(1)H bond acceptors: 3; (2)H bond donors: 2; (3)Freely Rotating Bonds: 0; (4)Index of Refraction: 1.413; (5)Molar Refractivity: 23.16 cm3; (6)Molar Volume: 92.8 cm³; (7)Surface Tension: 27.4 dyne/cm; (8)Density: 0.949 g/cm³; (9)Flash Point: 124.3 °C; (10)Enthalpy of Vaporization: 50.71 kJ/mol; (11)Boiling Point: 269 °C at 760 mmHg; (12)Vapour Pressure: 0.00744 mmHg at 25°C; (13)EINECS: 202-498-7; (14)Melting point: 101-104 °C(lit.); (15)Storage temp: Store at RT. ; (16)Water Solubility: 765 g/L (21.5 oC); (17)BRN: 1740672; (18)Polar Surface Area: 23.55 Å²

Structure Descriptors of 1,3-Dimethylurea:
(1)SMILES:O=C(NC)NC;
(2)Std. InChI:InChI=1S/C3H8N2O/c1-4-3(6)5-2/h1-2H3,(H2,4,5,6);
(3)Std. InChIKey:MGJKQDOBUOMPEZ-UHFFFAOYSA-N.

Toxicity of 1,3-Dimethylurea:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LDLo	intraperitoneal	4962mg/kg (4962mg/kg)	BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Journal of Pharmacology and Experimental Therapeutics. Vol. 54, Pg. 188, 1935.
rat	LD50	unreported	> 2gm/kg (2000mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1073, 1969.

Use of 1,3-Dimethylurea:
1,3-Dimethylurea is used for synthesis of caffeine, theophylline, pharmachemicals, textile aids, herbicides and others. In the textile processing industry 1,3-dimethylurea is used as intermediate for the production of formaldehyde-free easy-care finishing agents for textiles. The estimated world production of DMU is estimated to be less than 25,000 tons.

Product Name

1,3-Dimethylurea

Synthetic route

1,3-Dimethylurea Consensus Reports

1,3-Dimethylurea Specification

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