1,3-Propanediol supplier | CasNO.504-63-2

Name
1,3-Propanediol
EINECS 207-997-3
CAS No. 504-63-2
Article Data339
CAS DataBase
Density 1.041 g/cm³
Solubility 100 g/L in water
Melting Point -32 °C
Formula C₃H₈O₂
Boiling Point 214.4 °C at 760 mmHg
Molecular Weight 76.0953
Flash Point 79.4 °C
Transport Information
Appearance clear oily liquid
Safety 23-24/25
Risk Codes 38
Molecular Structure
Hazard Symbols Xi
Synonyms 1,3-Dihydroxypropane;1,3-Propylene glycol;1,3-Propylenediol;2-Deoxyglycerol;Bio-PDO;NSC 65426;PG;Trimethylene glycol;Zemea;b-Propylene glycol;w-Propanediol;
PSA 40.46000
LogP -0.63890

Synthetic route

: 1589-49-7
methoxypropanol

: 504-63-2
trimethyleneglycol

Conditions

Conditions	Yield
With Strong acid resin at 100℃; for 1h; Temperature; Reagent/catalyst;	99.2%
With phosphoric acid; hydrogen iodide; sodium iodide at 105℃; Reagent/catalyst; Autoclave;	88%
With water; sulfuric acid at 190℃; for 10h; Product distribution / selectivity;

: 2453-03-4
trimethylene carbonate

: 504-63-2
trimethyleneglycol

Conditions

Conditions	Yield
With [carbonylchlorohydrido{bis[2-(diphenylphosphinomethyl)ethyl]amino}ethylamino] ruthenium(II); potassium tert-butylate; hydrogen In tetrahydrofuran at 140℃; under 38002.6 Torr; for 2h; Pressure; Autoclave;	99%
With zinc bis(2,4-pentanedionate) monohydrate In benzene at 70℃; for 3h; Inert atmosphere;

: C11H24O2

A: 115-11-7
isobutene

B: 504-63-2
trimethyleneglycol

Conditions

Conditions	Yield
With A35 resin acid at 100℃; for 2h; Temperature; Reagent/catalyst;	A n/a B 98%

: 627-18-9
1-bromo-3-propanol

: 504-63-2
trimethyleneglycol

Conditions

Conditions	Yield
With hexaethylene glycol bis(3-hexaethylene glycol imidazolium) dimesylate; potassium carbonate In water at 100℃; for 1h; Green chemistry; chemoselective reaction;	96%
With water; potassium carbonate at 90℃; for 0.5h; Green chemistry;	96%

: 56-81-5
glycerol

: 504-63-2
trimethyleneglycol

Conditions

Conditions	Yield
With hydrogen In water at 190℃; under 31029.7 Torr; Temperature; Pressure; Reagent/catalyst;	95%
With 1,3-dimethyl-2-imidazolidinone; hydrogen at 170℃; under 60006 Torr; for 20h; Reagent/catalyst; Large scale;	87%
With hydrogen at 119.84℃; under 60006 Torr; for 1h; Autoclave;	33%

: 2134-29-4
3-Hydroxypropanal

: 504-63-2
trimethyleneglycol

Conditions

Conditions	Yield
With sulfuric acid; nickel In water	95%
With hydrogen at 80℃; under 15001.5 Torr; for 2h; Catalytic behavior; Reagent/catalyst; Green chemistry;	76.9%
Hydrogenation;

: 695-30-7
2,2-dimethyl-1,3-dioxane

: 504-63-2
trimethyleneglycol

Conditions

Conditions	Yield
With sodium hydrogen sulfate; silica gel In dichloromethane; isopropyl alcohol at 20℃; for 5h;	95%

: 5689-71-4
2-(4-methoxy-phenyl)-[1,3]dioxane

: 504-63-2
trimethyleneglycol

Conditions

Conditions	Yield
With sodium hydrogen sulfate; silica gel In dichloromethane; isopropyl alcohol at 20℃; for 3h;	92%

: 1-tert-butyldimethylsilyloxy-3-triethylsilyloxypropane

A: 73842-99-6
3-tert-butyldimethylsilyloxy-1-propanol

B: 504-63-2
trimethyleneglycol

Conditions

Conditions	Yield
With MCM-41 In methanol for 4h; Ambient temperature;	A 91% B 3%
With mesoporous silica MCM-41 In methanol at 20℃; for 4h;	A 91% B 3%

: 141-82-2
malonic acid

: 504-63-2
trimethyleneglycol

Conditions

Conditions	Yield
With borohydride exchange resin In methanol Ambient temperature;	90%

: 105-53-3
diethyl malonate

: 504-63-2
trimethyleneglycol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In benzene at 80℃;	87%
With lithium aluminium tetrahydride In tetrahydrofuran	74%
With C17H38ClNORuS2; potassium tert-butylate; hydrogen In toluene at 110℃; under 775.743 Torr; for 24h; Reagent/catalyst; Temperature; Pressure; Inert atmosphere;	67%

: tert-Butyl-(3-methoxymethoxy-propoxy)-dimethyl-silane

: 504-63-2
trimethyleneglycol

Conditions

Conditions	Yield
With cerium(III) chloride; sodium iodide In acetonitrile for 10h; Ambient temperature;	87%

: 4799-68-2
3-benzyloxypropan-1-ol

: 504-63-2
trimethyleneglycol

Conditions

Conditions	Yield
Stage #1: 3-benzyloxypropan-1-ol With isocyanate de chlorosulfonyle; sodium carbonate In dichloromethane for 20h; Heating; Stage #2: With sodium hydroxide In methanol at 20℃; for 1h;	87%

: 1,3-bis(trityloxy)propane

: 504-63-2
trimethyleneglycol

Conditions

Conditions	Yield
With sodium hydrogen sulfate; silica gel In methanol; dichloromethane at 20℃; for 2.5h;	87%

: 36678-05-4
6-hydroxy-3-oxa-2-hexanone

: 504-63-2
trimethyleneglycol

Conditions

Conditions	Yield
With amberlite IR120 ion exchange resin In water; toluene at 75℃; under 3750.38 Torr; for 7h; Inert atmosphere; Autoclave;	80.42%
With amberlite IR120 ion exchange resin In water; toluene at 75℃; under 3750.38 Torr; for 7h; Inert atmosphere; Autoclave;	80.29%
With sodium methylate In methanol at 65℃; under 3750.38 Torr; for 4h; Inert atmosphere; Autoclave;	80.37%

: 203738-77-6
3-tert-butyldimethylsilyloxy-1-propyl benzyl ether

A: 73842-99-6
3-tert-butyldimethylsilyloxy-1-propanol

B: 504-63-2
trimethyleneglycol

Conditions

Conditions	Yield
With Ti-HMS; hydrogen; 5% Pd on active carbon In methanol under 760 Torr; for 4h; Ambient temperature;	A 80% B 7%
With hydrogen; palladium on activated charcoal In methanol at 20℃; for 24h; Title compound not separated from byproducts.;

: 2453-03-4
trimethylene carbonate

A: 67-56-1
methanol

B: 504-63-2
trimethyleneglycol

Conditions

Conditions	Yield
With (bis[(2-diisopropylphosphino)ethyl]amine)Mn(CO)2Br; hydrogen; sodium t-butanolate In tetrahydrofuran at 120℃; under 22502.3 Torr; for 26h; Schlenk technique; Glovebox; Autoclave;	A 75% B 80%
With [carbonylchlorohydrido{bis[2-(diphenylphosphinomethyl)ethyl]amino}ethylamino] ruthenium(II); potassium tert-butylate; hydrogen In tetrahydrofuran at 140℃; for 2h; Autoclave;	A 99 %Chromat. B 99 %Chromat.
With hydrogen In tetrahydrofuran at 159.84℃; under 45004.5 Torr; for 10h;

: 503-66-2
3-hydroxypropionic acid

A: 71-23-8
propan-1-ol

B: 504-63-2
trimethyleneglycol

Conditions

Conditions	Yield
With ruthenium-carbon composite; hydrogen In water at 119.84℃; under 7500.75 - 60006 Torr; for 2h; Catalytic behavior; Autoclave; Sealed tube;	A 18% B 79%

: 220061-73-4
2-(3-Benzyloxy-propoxy)-tetrahydro-pyran

: 504-63-2
trimethyleneglycol

Conditions

Conditions	Yield
With hydrogen; toluene-4-sulfonic acid; palladium dihydroxide In methanol under 760 Torr; for 4h; Ambient temperature;	74%

: C12H17NO2

: 504-63-2
trimethyleneglycol

Conditions

Conditions	Yield
In methanol for 0.5h; UV-irradiation;	74%

: 53088-81-6
1,3-bis(benzyloxy)propane

: 504-63-2
trimethyleneglycol

Conditions

Conditions	Yield
Stage #1: 1,3-bis(benzyloxy)propane With isocyanate de chlorosulfonyle; sodium carbonate In dichloromethane for 20h; Heating; Stage #2: With sodium hydroxide In methanol at 20℃; for 1h;	70%

: 556-52-5
oxiranyl-methanol

: 504-63-2
trimethyleneglycol

Conditions

Conditions	Yield
With hydrogen In ethanol at 150℃; under 37503.8 Torr; for 8h; Temperature; Pressure; Flow reactor;	68%
With ammonia borane; C28H28Cl2CoNP2; erbium(III) triflate In tetrahydrofuran at 45℃; for 8h;	82 %Chromat.

: 1,3-dihydroxypropan-2-yl methanesulfonate

: 504-63-2
trimethyleneglycol

Conditions

Conditions	Yield
With hydrogen at 110℃; under 22502.3 Torr; for 3h;	65.9%

: 73684-56-7
2-p-toluenesulfonyloxy-1,3-propanediol

: 504-63-2
trimethyleneglycol

Conditions

Conditions	Yield
With hydrogen; palladium In tetrahydrofuran at 130℃; under 15001.5 Torr; for 3h; Pressure; Reagent/catalyst; Solvent; Temperature;	64.6%

: 203738-77-6
3-tert-butyldimethylsilyloxy-1-propyl benzyl ether

A: 4799-68-2
3-benzyloxypropan-1-ol

B: 73842-99-6
3-tert-butyldimethylsilyloxy-1-propanol

C: 504-63-2
trimethyleneglycol

Conditions

Conditions	Yield
In methanol under 760 Torr; for 20h; Ambient temperature;	A 6% B 64% C 9%

...Expand

: 108-59-8
malonic acid dimethyl ester

: 504-63-2
trimethyleneglycol

Conditions

Conditions	Yield
With C17H38ClNORuS2; potassium tert-butylate; hydrogen In toluene at 110℃; under 775.743 Torr; for 24h; Inert atmosphere;	62%
With sodium tetrahydroborate; [fac-8-(2-diphenylphosphinoethyl)amidotrihydroquinoline]RuH(PPh3)(CO); hydrogen In tetrahydrofuran at 120℃; under 38002.6 Torr; for 18h; Autoclave; Industrial scale;
With sodium tetrahydroborate; [fac-8-(2-diphenylphosphinoethyl)amidotrihydroquinoline]RuH(PPh)3(CO); hydrogen In tetrahydrofuran at 120℃; under 37503.8 Torr; for 18h; Inert atmosphere; Autoclave;

: 503-66-2
3-hydroxypropionic acid

: 504-63-2
trimethyleneglycol

Conditions

Conditions	Yield
With hydrogen; molybdenum(IV) oxide In water at 150℃; under 78334.3 Torr; for 3h; Product distribution / selectivity;	60%
With hydrogen; molybdenum In ISOPAR K; water at 150℃; under 78334.3 Torr; for 3h; Product distribution / selectivity;	57%
With hydrogen In water at 100℃; under 78334.3 Torr; for 16h; Product distribution / selectivity;	47%

: 56-81-5
glycerol

A: 71-23-8
propan-1-ol

B: 67-63-0
isopropyl alcohol

C: 504-63-2
trimethyleneglycol

Conditions

Conditions	Yield
With hydrogen In water at 179.84℃; under 22502.3 Torr; for 4h; Autoclave;	A 47% B 6% C 21%
With hydrogen In water at 179.84℃; under 22502.3 Torr; for 10h; Autoclave;	A 34% B 14% C 40%
With hydrogen In water at 119.84℃; under 60006 Torr; for 12h; Reagent/catalyst;	A n/a B n/a C 36%

...Expand

: 556-52-5
oxiranyl-methanol

A: 71-23-8
propan-1-ol

B: 57-55-6
propylene glycol

C: 504-63-2
trimethyleneglycol

Conditions

Conditions	Yield
With hydrogen In sulfolane at 119.84℃; under 37503.8 Torr; for 4h;	A n/a B n/a C 46.1%
With hydrogen In sulfolane at 119.84℃; under 37503.8 Torr; for 4h; Reagent/catalyst;	A n/a B n/a C 11.7%
With hydrogen In ethanol at 120℃; under 15001.5 Torr; for 5h; Reagent/catalyst;
With hydrogen In ethanol at 120℃; under 15001.5 Torr; for 5h; Reagent/catalyst;

...Expand

: 123-11-5
4-methoxy-benzaldehyde

: 504-63-2
trimethyleneglycol

: 5689-71-4
2-(4-methoxy-phenyl)-[1,3]dioxane

Conditions

Conditions	Yield
In benzene Cyclization; Heating;	100%
With toluene-4-sulfonic acid In toluene at 110℃; Condensation;	100%
toluene-4-sulfonic acid In toluene at 110℃; for 11h;	100%

: 97-97-2
chloroacetaldehyde dimethyl acetal

: 504-63-2
trimethyleneglycol

: 5695-72-7
2-Chloromethyl-1,3-dioxane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid Heating;	100%
Substitution;	91%
With sulfuric acid
sulfuric acid
With toluene-4-sulfonic acid at 115℃; for 5h;

: 18162-48-6
tert-butyldimethylsilyl chloride

: 504-63-2
trimethyleneglycol

: 73842-99-6
3-tert-butyldimethylsilyloxy-1-propanol

Conditions

Conditions	Yield
With sodium hydride In tetrahydrofuran	100%
With dmap; triethylamine In dichloromethane at 18℃;	100%
Stage #1: trimethyleneglycol With sodium hydride In tetrahydrofuran at 20℃; for 0.75h; Stage #2: tert-butyldimethylsilyl chloride In tetrahydrofuran at 20℃; for 0.75h;	99%

: 1122-91-4
4-bromo-benzaldehyde

: 504-63-2
trimethyleneglycol

: 61568-51-2
2-(4-bromophenyl)-1,3-dioxane

Conditions

Conditions	Yield
With Amberlyst 15 In benzene for 3h; Heating;	100%
With boron trifluoride diethyl etherate In toluene for 4.5h; Acetalization; Heating;	96%
With boron trifluoride diethyl etherate In toluene at 100℃; for 4.5h;	96%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 504-63-2
trimethyleneglycol

: 127047-71-6
3-(tert-butyldiphenylsilyloxy)propan-1-ol

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran; hexane at -78 - 25℃; Substitution; Heating;	100%
Stage #1: trimethyleneglycol With sodium hydride In tetrahydrofuran at 20℃; for 1h; deprotonation; Stage #2: tert-butylchlorodiphenylsilane In tetrahydrofuran at 0℃; for 2h; silylation;	100%
With pyridine at 0 - 22℃;	100%

: 123-73-9
crotonaldehyde

: 504-63-2
trimethyleneglycol

: 2-(2-chloropropyl)-1,3-dioxane

Conditions

Conditions	Yield
With hydrogenchloride; tetrabutyl-ammonium chloride	100%
With chloro-trimethyl-silane In dichloromethane at 5 - 20℃; Reflux; Inert atmosphere;

: 140-10-3
(E)-3-phenylacrylic acid

: 504-63-2
trimethyleneglycol

: (E)-3-hydroxypropyl 3-phenylprop-2-enoate

Conditions

Conditions	Yield
With sulfuric acid In toluene Heating;	100%

: 85565-93-1
2-bromo-3,5-dimethoxy-benzaldehyde

: 504-63-2
trimethyleneglycol

: 133056-50-5
2-(2-Bromo-3,5-dimethoxyphenyl)-1,3-dioxane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene for 2h; Heating;	100%
With toluene-4-sulfonic acid In benzene for 2h; Heating;	100%
With tetra-N-butylammonium tribromide; orthoformic acid triethyl ester at 0 - 20℃;	94%

: 77377-52-7
N-methyl-N-tert-butyldimethylsilyl-1,1,1-trifluoroacetamide

: 504-63-2
trimethyleneglycol

: 82112-22-9
1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-propane

Conditions

Conditions	Yield
With tert-butyldimethylsilyl chloride In acetonitrile for 0.0833333h; Product distribution; Ambient temperature; other tert-butyldimethylsilyl- donors; other alkohols; other solvent, temp. and time;	100%
With tert-butyldimethylsilyl chloride In acetonitrile for 0.0833333h; Ambient temperature; other silylating agents;	100%

: 75898-24-7
1,2 bis (tricosa 10,12 diynoyl)-sn-3-glycerophosphocholine, DC8,9PC

: 504-63-2
trimethyleneglycol

: 150891-84-2
DC8,9 phosphatidylhydroxypropanol

Conditions

Conditions	Yield
With acetate buffer In isopropyl alcohol at 37℃; for 10h; phospholipase D;	100%

: C28H32N2O4

: 504-63-2
trimethyleneglycol

: 151158-47-3
C31H38N2O5

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene Heating;	100%

: 152429-51-1
6-allyl-2,6-dimethyl-1-cyclohexene-1-carbaldehyde

: 504-63-2
trimethyleneglycol

: 152429-52-2
6-allyl-2,6-dimethyl-1-cyclohexene-1-carbaldehyde trimethyleneacetal

Conditions

Conditions	Yield
With pyridinium p-toluenesulfonate In benzene for 4h; Heating;	100%

: 3132-99-8
m-bromobenzoic aldehyde

: 504-63-2
trimethyleneglycol

: 67437-93-8
2-(3-bromophenyl)-[1,3]dioxane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene for 15.5h; Reflux; Dean-Stark;	100%
With toluene-4-sulfonic acid In toluene for 2.5h; Heating;	99%
With toluene-4-sulfonic acid In toluene at 20℃; for 2.5h;	96%

: 267660-71-9
3-(N-Ethylamino)phenylboronic acid

: 504-63-2
trimethyleneglycol

: 267660-72-0
N-Ethyl-3-(1,3,2-dioxaborinan-2-yl)aniline

Conditions

Conditions	Yield
In toluene for 14h; Etherification; Cyclization; Heating;	100%
In toluene refluxed, 14 h; evapd. to dryness; column chromy. (silica gel-ethyl acetate);	>99

: 197960-66-0
3-hydroxy-5-methylphenyl 2-(methylsulfonyl)benzenesulfonate

: 504-63-2
trimethyleneglycol

: 197960-67-1
3-[5-methyl-3-[2-(methylsulfonyl)phenylsulfonyloxy]phenoxy]propanol

Conditions

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; Mitsunobu reaction;	100%
With tributylphosphine; 1,1'-azodicarbonyl-dipiperidine Condensation;
With bithionol; 1,1'-azodicarbonyl-dipiperidine In tetrahydrofuran Mitsunobu reaction;

: 265991-10-4
7,10-dimethoxy-5,6,11,12-tetrahydro-2-naphthacenecarbaldehyde

: 504-63-2
trimethyleneglycol

: 265991-11-5
7,10-dimethoxy-5,6,11,12-tetrahydro-2-naphthacenecarbaldehyde 1,3-propylene acetal

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene for 3h; Condensation; Heating;	100%

: 504-63-2
trimethyleneglycol

: 667888-81-5
C11H19BO2

: 667888-74-6
2-[(1E,4Z,6Z)-1,4,6-undecatrien-1-yl]-1,2,3-dioxaborinane

Conditions

Conditions	Yield
In pentane at 20℃; for 10h;	100%

: 87199-17-5
4-formylphenylboronic acid,

: 504-63-2
trimethyleneglycol

: 4-(1,3,2-dioxaborinan-2-yl)-benzaldehyde

Conditions

Conditions	Yield
In toluene at 135℃; for 5h; Inert atmosphere; Dean-Stark;	100%
In toluene for 12h; Reflux;

: 52387-36-7
6-chlorohexanal

: 504-63-2
trimethyleneglycol

: 84231-09-4
2-(5-chloropentyl)-1,3-dioxane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene for 3h; Inert atmosphere; Reflux;	100%

: 1201829-81-3
(R)-3-methyl-4,4-bis(phenylsulfonyl)butanal

: 504-63-2
trimethyleneglycol

: 1201829-96-0
(R)-2-(2-methyl-3,3-bis(phenylsulfonyl)propyl)-1,3-dioxane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene Heating;	100%

: 105942-10-7
3-fluoro-4-formylbenzonitrile

: 504-63-2
trimethyleneglycol

: 1164204-49-2
4-(1,3-Dioxan-2-yl)-3-fluorobenzonitrile

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene for 6h; Reflux;	100%

: 5843-26-5
tetramethylphosphorodiamidous acid

: 504-63-2
trimethyleneglycol

: 16352-21-9
1,3,2-dioxaphosphinan-2-oxide

Conditions

Conditions	Yield
In tetrahydrofuran at 70℃; for 2h; Inert atmosphere;	100%

: 926038-69-9
C22H27BO3

: 504-63-2
trimethyleneglycol

: 1331832-81-5
C25H31BO3

Conditions

Conditions	Yield
In toluene for 2h; Reflux;	100%

: 616-38-6
carbonic acid dimethyl ester

: 504-63-2
trimethyleneglycol

: 179902-20-6
propane-1,3-diyl dimethyl dicarbonate

Conditions

Conditions	Yield
at 120℃; for 7h; Molecular sieve;	100%
In neat (no solvent) at 120℃; for 1h; Molecular sieve; Green chemistry;	99%
With dicobalt octacarbonyl at 180℃; for 1h;	98%
With magnesium oxide at 80℃; under 760.051 Torr; for 4h;	91.3%

: 952006-62-1
5,8-dimethoxy-1,2,3,4-tetrahydro-1,4-methanonaphthalene-6-carboxaldehyde

: 504-63-2
trimethyleneglycol

: 2-(5,8-dimethoxy-1,2,3,4-tetrahydro-1,4-methanonaphthalen-6-yl)-1,3-dioxane

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In toluene for 4h; Dean-Stark; Reflux;	100%

: 1000990-16-8
2-bromo-3,5-dimethylbenzaldehyde

: 504-63-2
trimethyleneglycol

: 2-(2-bromo-3,5-dimethylphenyl)-1,3-dioxane

Conditions

Conditions	Yield
Stage #1: 2-bromo-3,5-dimethylbenzaldehyde; trimethyleneglycol With toluene-4-sulfonic acid In chloroform for 18h; Reflux; Stage #2: With potassium carbonate In chloroform at 25℃;	100%

: (E)-methyl 2-(4-methoxy-2-(3-oxoprop-1-en-1-yl)phenyl)acetate

: 504-63-2
trimethyleneglycol

: (E)-methyl 2-(2-(2-(1,3-dioxan-2-yl)vinyl)-4-methoxyphenyl)acetate

Conditions

Conditions	Yield
With methanol; N-Bromosuccinimide; trimethyl orthoformate In dichloromethane at 0 - 20℃; for 20h;	100%

: 155351-68-1
2-O-benzyl-5-bromo-2-hydroxy-3-methoxybenzaldehyde

: 504-63-2
trimethyleneglycol

: 155351-69-2
2-(benzyloxy)-5-bromo-3-methoxybenzaldehyde trimethylene acetal

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In benzene for 1h; Heating;	99.7%

1,3-Propanediol Chemical Properties

Molecule structure of 1,3-Propanediol (CAS NO.504-63-2):

IUPAC Name: Propane-1,3-diol
Molecular Weight: 76.09442 g/mol
Molecular Formula: C₃H₈O₂
Density: 1.041 g/cm³
Melting Point: -32 °C
Boiling Point: 214.4 °C at 760 mmHg
Flash Point: 79.4 °C
Index of Refraction: 1.433
Molar Refractivity: 19.01 cm³
Molar Volume: 73 cm³
Surface Tension: 41 dyne/cm
Enthalpy of Vaporization: 52.42 kJ/mol
Vapour Pressure: 0.0343 mmHg at 25 °C
Water Solubility: 100 g/L
XLogP3: -1
H-Bond Donor: 2
H-Bond Acceptor: 2
Rotatable Bond Count: 2
Exact Mass: 76.05243
MonoIsotopic Mass: 76.05243
Topological Polar Surface Area: 40.5
Heavy Atom Count: 5
Canonical SMILES: C(CO)CO
InChI: InChI=1S/C3H8O2/c4-2-1-3-5/h4-5H,1-3H2
InChIKey: YPFDHNVEDLHUCE-UHFFFAOYSA-N
EINECS: 207-997-3
Product Categories: alpha,omega-Alkanediols; alpha,omega-Bifunctional Alkanes; Monofunctional & alpha,omega-Bifunctional Alkanes; Cell culture

1,3-Propanediol Uses

1,3-Propanediol (CAS NO.504-63-2) is a solvent and used as an wood paint and antifreeze. It mainly used as a building block in the production of polymers. It also can be formulated into a variety of industrial products including composites, coatings, laminates, moldings, aliphatic polyesters.

1,3-Propanediol Production

1,3-Propanediol may be chemically made by the hydration of acrolein, or by the hydroformylation of ethylene oxide to afford 3-hydroxypropionaldehyde. The aldehyde is hydrogenated to give 1,3-propanediol.

1,3-Propanediol Toxicity Data With Reference

1.	dnd-rat-orl 2100 mg/kg/10W-C	CBINA8 Chemico-Biological Interactions. 50 (1984),87.
2.	orl-rat LDLo:10 g/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 72 (1941),227.
3.	ims-rat LDLo:6 g/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 72 (1941),227.
4.	orl-mus LD50:4773 mg/kg	TXAPA9 Toxicology and Applied Pharmacology. 49 (1979),385.

1,3-Propanediol Consensus Reports

Reported in EPA TSCA Inventory.

1,3-Propanediol Safety Profile

Safety Statements: 23-24/25
S23:Do not breathe vapour.
S24/25:Avoid contact with skin and eyes.
WGK Germany: 1
RTECS: TY2010000
HS Code: 29053980
Mildly toxic by ingestion. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. See also 1,2-PROPANEDIOL.

1,3-Propanediol Specification

1,3-Propanediol (CAS NO.504-63-2) is also named as 1,3-Dihydroxypropane ; 1,3-Propylene glycol ; 1,3-Propylenediol ; 2-(Hydroxymethyl)ethanol ; 2-Deoxyglycerol ; 4-01-00-02493 (Beilstein Handbook Reference) ; AI3-01851 ; BRN 0969155 ; NSC 65426 ; PG ; Trimethylene glycol ; beta-Propylene glycol ; omega-Propanediol . 1,3-Propanediol (CAS NO.504-63-2) is clear oily liquid.

Product Name

1,3-Propanediol

Synthetic route

1,3-Propanediol Chemical Properties

1,3-Propanediol Uses

1,3-Propanediol Production

1,3-Propanediol Toxicity Data With Reference

1,3-Propanediol Consensus Reports

1,3-Propanediol Safety Profile

1,3-Propanediol Specification

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