Product Name

  • Name

    1,6-Dibromohexane

  • EINECS 211-067-2
  • CAS No. 629-03-8
  • Article Data36
  • CAS DataBase
  • Density 1.584 g/cm3
  • Solubility insoluble in water
  • Melting Point -2-2.5 °C(lit.)
  • Formula C6H12Br2
  • Boiling Point 244.1 °C at 760 mmHg
  • Molecular Weight 243.969
  • Flash Point 110.8 °C
  • Transport Information UN 2810 6.1/PG 3
  • Appearance Colorless or pale yellow liquid.
  • Safety 36-45-61
  • Risk Codes 25-51/53
  • Molecular Structure Molecular Structure of 629-03-8 (1,6-Dibromohexane)
  • Hazard Symbols ToxicT, DangerousN, CorrosiveC
  • Synonyms 1,6-Dibromo-n-hexane;Hexamethylene dibromide;a,w-Dibromohexane;
  • PSA 0.00000
  • LogP 3.33660

Synthetic route

1,6-hexanediol
629-11-8

1,6-hexanediol

1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

Conditions
ConditionsYield
With N-Bromosuccinimide; triphenylphosphine In dichloromethane at -78 - 20℃; for 12h; Darkness; chemoselective reaction;97%
With sulfuric acid; hydrogen bromide
With hydrogen bromide folgendes Erhitzen;
1,6-hexanediol
629-11-8

1,6-hexanediol

A

1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

B

1-bromo-6-hexanol
4286-55-9

1-bromo-6-hexanol

Conditions
ConditionsYield
With hydrogen bromide In toluene for 13h; Substitution; Heating;A n/a
B 79%
With hydrogen bromide In toluene for 24h; Heating;A 1%
B 69%
O-6-oxohexyl dimethylcarbamothioate
1110667-69-0

O-6-oxohexyl dimethylcarbamothioate

A

1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

B

6-bromohexanal
57978-00-4

6-bromohexanal

Conditions
ConditionsYield
With 4-(bromomethylene)morpholin-4-ium bromide In dichloromethane at 0℃; for 1h; Inert atmosphere;A 5%
B 75%
O-6-hydroxyhexyl dimethylcarbamothioate
1110667-72-5

O-6-hydroxyhexyl dimethylcarbamothioate

A

1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

B

1-bromo-6-hexanol
4286-55-9

1-bromo-6-hexanol

C

C7H13BrO2
1110667-79-2

C7H13BrO2

D

6-bromohexyl dimethylthiocarbamate
1110667-78-1

6-bromohexyl dimethylthiocarbamate

Conditions
ConditionsYield
With 4-(bromomethylene)morpholin-4-ium bromide In dichloromethane at 0℃; for 0.5h; Inert atmosphere;A 18%
B 13%
C 10%
D 59%
O-6-hydroxyhexyl dimethylcarbamothioate
1110667-72-5

O-6-hydroxyhexyl dimethylcarbamothioate

A

1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

B

1-bromo-6-hexanol
4286-55-9

1-bromo-6-hexanol

C

6-bromohexyl dimethylthiocarbamate
1110667-78-1

6-bromohexyl dimethylthiocarbamate

Conditions
ConditionsYield
With 4-(bromomethylene)morpholin-4-ium bromide In dichloromethane at 0℃; for 24h; Inert atmosphere;A 44%
B 4%
C 50%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

acrylic acid methyl ester
292638-85-8

acrylic acid methyl ester

6-azido-hexylamine
349553-73-7

6-azido-hexylamine

1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane40%
O-6-(tetrahydro-2H-pyran-2-yloxy)hexyl dimethylcarbamothioate
1110667-75-8

O-6-(tetrahydro-2H-pyran-2-yloxy)hexyl dimethylcarbamothioate

A

1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

B

2-[(6-bromohexyl)oxy]tetrahydro-2H-pyran
53963-10-3

2-[(6-bromohexyl)oxy]tetrahydro-2H-pyran

C

1-bromo-6-hexanol
4286-55-9

1-bromo-6-hexanol

D

C7H13BrO2
1110667-79-2

C7H13BrO2

Conditions
ConditionsYield
With 4-(bromomethylene)morpholin-4-ium bromide In dichloromethane at 0℃; for 1.5h; Inert atmosphere;A 5%
B 14%
C 27%
D 23%
O-6-(tert-butyldimethylsiloxy)hexyl dimethylcarbamothioate
1110667-76-9

O-6-(tert-butyldimethylsiloxy)hexyl dimethylcarbamothioate

A

1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

B

1-bromo-6-hexanol
4286-55-9

1-bromo-6-hexanol

C

tert-butyldimethylsilanol
18173-64-3

tert-butyldimethylsilanol

D

(6-bromohexyloxy)-tert-butyldimethylsilane
129368-70-3

(6-bromohexyloxy)-tert-butyldimethylsilane

Conditions
ConditionsYield
With 4-(bromomethylene)morpholin-4-ium bromide In dichloromethane at 0℃; for 2h; Inert atmosphere;A 10%
B 21%
C 13%
D 26%
1,5-Hexadien
592-42-7

1,5-Hexadien

1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

Conditions
ConditionsYield
With hydrogen bromide at -78℃; Irradiation.mit UV-Licht;
1,3-dibromo-propane
109-64-8

1,3-dibromo-propane

sodium

sodium

A

1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

B

propene
187737-37-7

propene

C

cyclopropane
75-19-4

cyclopropane

Conditions
ConditionsYield
unter Luminescenz;
diacetate of hexanediol-(1.6)

diacetate of hexanediol-(1.6)

1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

Conditions
ConditionsYield
With hydrogen bromide at 120℃;
dibenzoylhexamethylenediamine

dibenzoylhexamethylenediamine

1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

Conditions
ConditionsYield
With phosphorus pentabromide nachfolgende Destillation des Reaktionsproduktes unter 20 mm Druck;
hexanediol-(1.6)-diethyl ether

hexanediol-(1.6)-diethyl ether

1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

Conditions
ConditionsYield
With hydrogen bromide at 150℃;
hexanediol-(1.6)-diphenyl ether

hexanediol-(1.6)-diphenyl ether

1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

Conditions
ConditionsYield
With hydrogen bromide at 150 - 160℃;
N-benzoyl-hexamethyleneimine

N-benzoyl-hexamethyleneimine

1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

Conditions
ConditionsYield
With phosphorus pentabromide
1,6-hexanediol
629-11-8

1,6-hexanediol

hydrogen bromide
10035-10-6, 12258-64-9

hydrogen bromide

1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

Conditions
ConditionsYield
at 120 - 130℃;
1,5-Hexadien
592-42-7

1,5-Hexadien

hydrogen bromide
10035-10-6, 12258-64-9

hydrogen bromide

1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

Conditions
ConditionsYield
at -78℃; UV-Strahlen.Irradiation;
1,6-bis-(6-hydroxy-hexyloxy)-hexane
4161-35-7

1,6-bis-(6-hydroxy-hexyloxy)-hexane

hydrogen bromide
10035-10-6, 12258-64-9

hydrogen bromide

1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

Conditions
ConditionsYield
at 100℃;
1,6-hexanediol
629-11-8

1,6-hexanediol

concentrated HBr

concentrated HBr

1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

bis-(6-bromo-hexyl)-ether
91692-05-6

bis-(6-bromo-hexyl)-ether

excessive hydrobromic acid

excessive hydrobromic acid

1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

Conditions
ConditionsYield
at 125 - 126℃; im Rohr;
1,6-hexanediol
629-11-8

1,6-hexanediol

hydrogen bromide
10035-10-6, 12258-64-9

hydrogen bromide

A

1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

B

bis-(6-bromo-hexyl)-ether
91692-05-6

bis-(6-bromo-hexyl)-ether

C

hexamethylene oxide

hexamethylene oxide

Conditions
ConditionsYield
at 195℃;
N,N'-dibenzoylhexane-1,6-diamine
5326-21-6

N,N'-dibenzoylhexane-1,6-diamine

phosphorus pentabromide
7789-69-7

phosphorus pentabromide

1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

Conditions
ConditionsYield
nachfolgend Destillation unter vermindertem Druck;
diethyl adipate
141-28-6

diethyl adipate

1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: durch Reduktion
2: hydrogen bromide / 120 - 130 °C
View Scheme
trans-[4-(6-Bromo-hexyloxy)-cyclohexyl]-carbamic acid benzyl ester

trans-[4-(6-Bromo-hexyloxy)-cyclohexyl]-carbamic acid benzyl ester

A

1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

B

(trans)-(4-hydroxy-cyclohexyl)-carbamic acid benzyl ester
27489-63-0, 149423-75-6, 16801-62-0

(trans)-(4-hydroxy-cyclohexyl)-carbamic acid benzyl ester

1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

dimethyl amine
124-40-3

dimethyl amine

N,N,N',N'-tetramethylhexamethylenediamine
111-18-2

N,N,N',N'-tetramethylhexamethylenediamine

Conditions
ConditionsYield
In tetrahydrofuran at 0 - 20℃; for 24h;100%
In chloroform at 20℃; for 24h;100%
With sodium carbonate In ethanol; water for 24h; Heating;98%
1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

trimethylphosphane
594-09-2

trimethylphosphane

(6-Bromhexyl)trimethylphosphoniumbromid
72385-53-6

(6-Bromhexyl)trimethylphosphoniumbromid

Conditions
ConditionsYield
In toluene for 72h; Ambient temperature;100%
1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

3-(4-bromophenyl)benzo[d]isoxazol-6-ol
192443-32-6

3-(4-bromophenyl)benzo[d]isoxazol-6-ol

6-(6-bromohexyloxy)-3-(4-bromophenyl)benzo[d]isoxazole
579816-09-4

6-(6-bromohexyloxy)-3-(4-bromophenyl)benzo[d]isoxazole

Conditions
ConditionsYield
With potassium carbonate In acetone at 65℃; for 18h;100%
1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

(4-bromophenyl)(4-hydroxy-2-methylsulfanylphenyl)methanone
192437-40-4

(4-bromophenyl)(4-hydroxy-2-methylsulfanylphenyl)methanone

[4-[6-(bromo)hexyloxy]-2-methylsulfanylphenyl](4-bromophenyl)methanone
192437-42-6

[4-[6-(bromo)hexyloxy]-2-methylsulfanylphenyl](4-bromophenyl)methanone

Conditions
ConditionsYield
With potassium carbonate In acetone Heating;100%
4,4'-bipyridine
553-26-4

4,4'-bipyridine

1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

oligo(hexylene-4,4'-bipyridinium dibromide)

oligo(hexylene-4,4'-bipyridinium dibromide)

Conditions
ConditionsYield
In ethanol at 100℃; for 24h;100%
1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

1-azido-6-bromohexane
235095-05-3

1-azido-6-bromohexane

Conditions
ConditionsYield
With sodium azide In N,N-dimethyl-formamide at 20℃; Inert atmosphere;100%
With sodium azide In water; N,N-dimethyl-formamide at 60℃; for 28h;98%
With sodium azide In water; N,N-dimethyl-formamide at 60℃; for 24h;80%
1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

potassium [13C]cyanide

potassium [13C]cyanide

octanedinitrile-1,8-13C2

octanedinitrile-1,8-13C2

Conditions
ConditionsYield
In dimethyl sulfoxide at 75℃;100%
1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

C26H57N2(1+)

C26H57N2(1+)

C32H69BrN2(2+)

C32H69BrN2(2+)

Conditions
ConditionsYield
In acetone at 40℃; for 24h;99.9%
1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

isogentisine
491-64-5

isogentisine

C20H21BrO5

C20H21BrO5

Conditions
ConditionsYield
Stage #1: isogentisine With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: 1 ,6-dibromohexane In N,N-dimethyl-formamide at 20℃; for 20h;
99.8%
Stage #1: isogentisine With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: 1 ,6-dibromohexane In N,N-dimethyl-formamide at 20℃; for 12.5h;
1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

1,3-dihydroxy-6,7-dimethoxy-9H-xanthen-9-one
34318-15-5

1,3-dihydroxy-6,7-dimethoxy-9H-xanthen-9-one

C21H23BrO6

C21H23BrO6

Conditions
ConditionsYield
Stage #1: 1,3-dihydroxy-6,7-dimethoxy-9H-xanthen-9-one With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: 1 ,6-dibromohexane In N,N-dimethyl-formamide at 20℃; for 20h;
99.6%
Stage #1: 1,3-dihydroxy-6,7-dimethoxy-9H-xanthen-9-one With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: 1 ,6-dibromohexane In N,N-dimethyl-formamide at 20℃; for 12.5h;
1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

7-chloro-1,3-dihydroxy-9H-xanthen-9-one
100334-95-0

7-chloro-1,3-dihydroxy-9H-xanthen-9-one

C19H18BrClO4

C19H18BrClO4

Conditions
ConditionsYield
Stage #1: 7-chloro-1,3-dihydroxy-9H-xanthen-9-one With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: 1 ,6-dibromohexane In N,N-dimethyl-formamide at 20℃; for 20h;
99.4%
Stage #1: 7-chloro-1,3-dihydroxy-9H-xanthen-9-one With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: 1 ,6-dibromohexane In N,N-dimethyl-formamide at 20℃; for 12.5h;
1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

1,6-diazidohexane
13028-54-1

1,6-diazidohexane

Conditions
ConditionsYield
With sodium azide In water; N,N-dimethyl-formamide at 80℃; for 20h;99%
With sodium azide; potassium iodide In water; N,N-dimethyl-formamide at 90℃; for 120h;99%
With sodium azide In water; N,N-dimethyl-formamide at 80℃; for 22h;98%
1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

4-Hydroxyacetophenone
99-93-4

4-Hydroxyacetophenone

1,1'-<1,6-hexanediylbis(oxy-4,1-phenylene)>bisethanone
99174-33-1

1,1'-<1,6-hexanediylbis(oxy-4,1-phenylene)>bisethanone

Conditions
ConditionsYield
Stage #1: 4-Hydroxyacetophenone With potassium hydroxide In ethanol at 50 - 60℃; for 0.25h;
Stage #2: 1 ,6-dibromohexane In ethanol for 18h; Reflux;
99%
With potassium carbonate In acetone for 18h; Reflux;89%
With Aliquat 336; potassium carbonate; potassium iodide In acetone Heating;88%
1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

N,N-dimethylhexadecylamine
112-69-6

N,N-dimethylhexadecylamine

1,6-bis(N-hexadecyl-N,N-dimethylammonium)hexane dibromide
15590-96-2

1,6-bis(N-hexadecyl-N,N-dimethylammonium)hexane dibromide

Conditions
ConditionsYield
In ethanol at 80℃; for 48h;99%
In acetonitrile at 82℃; for 48h; Menshutkin Reaction;97%
In ethanol at 80℃; for 48h; Reflux;83%
1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

N,N-dimethyl-N-(3-phthalimidopropyl)amine
13474-65-2

N,N-dimethyl-N-(3-phthalimidopropyl)amine

Conditions
ConditionsYield
In acetonitrile for 0.35h; Microwave irradiation;99%
With potassium carbonate; potassium iodide at 100℃; for 2h; microwave irradiation;97%
With potassium carbonate; potassium iodide In acetonitrile Heating;
1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

ethyl acetoacetate
141-97-9

ethyl acetoacetate

decane-2,9-dione
16538-91-3

decane-2,9-dione

Conditions
ConditionsYield
With sodium ethanolate In ethanol Heating;99%
1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

Benzimidazol-2-thiol
134469-07-1

Benzimidazol-2-thiol

1,6-bis(2-benzimidazoylthio)hexane

1,6-bis(2-benzimidazoylthio)hexane

Conditions
ConditionsYield
99%
99%
1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

N,N-dimethyl-n-tetradecylamine
112-75-4

N,N-dimethyl-n-tetradecylamine

hexamethylene 1,6-bis(N-tetradecyl-N,N-dimethylammonium bromide)

hexamethylene 1,6-bis(N-tetradecyl-N,N-dimethylammonium bromide)

Conditions
ConditionsYield
In acetonitrile at 82℃; for 48h; Menshutkin Reaction;99%
In ethanol at 80℃; for 48h;80%
In ethanol Reflux;
1-phenylphospholane
3302-87-2

1-phenylphospholane

1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

1,6-bis(phenylphospholanium)hexane dibromide

1,6-bis(phenylphospholanium)hexane dibromide

Conditions
ConditionsYield
In acetonitrile at 80℃; for 48h; Inert atmosphere; Schlenk technique;99%
1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

1-aminodecane
2016-57-1

1-aminodecane

N1,N6-didecylhexane-1,6-diamine

N1,N6-didecylhexane-1,6-diamine

Conditions
ConditionsYield
With triethylamine In ethanol at 60℃; for 72h;99%
1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

N,N-dimethylhexadecylamine
112-69-6

N,N-dimethylhexadecylamine

C24H51BrN(1+)*Br(1-)

C24H51BrN(1+)*Br(1-)

Conditions
ConditionsYield
In diethyl ether at 40℃; for 12h; Temperature;99%
1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

methyl-4,5-dihydro-1H-imidazole
53517-93-4

methyl-4,5-dihydro-1H-imidazole

1,1'-(1,6-hexanediyl)bis[4,5-dihydro-3-methyl-1H-imidazol-3-ium] bromide

1,1'-(1,6-hexanediyl)bis[4,5-dihydro-3-methyl-1H-imidazol-3-ium] bromide

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 100℃; for 1h;99%
at 20 - 100℃; for 3.33333h;68%
1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

N,N-dimethyldecylamine
1120-24-7

N,N-dimethyldecylamine

C30H66N2(2+)*2Br(1-)
18699-36-0

C30H66N2(2+)*2Br(1-)

Conditions
ConditionsYield
In acetonitrile at 82℃; for 48h; Menshutkin Reaction;99%
In acetonitrile at 60℃; for 24h;92%
1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

1,3-dihydroxyxanthone
3875-68-1

1,3-dihydroxyxanthone

1-hydroxy-3-(6-bromo-hexyloxy)-9H-xanthene-9-one
1595287-76-5

1-hydroxy-3-(6-bromo-hexyloxy)-9H-xanthene-9-one

Conditions
ConditionsYield
Stage #1: 1,3-dihydroxyxanthone With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: 1 ,6-dibromohexane In N,N-dimethyl-formamide at 20℃; for 20h;
98.7%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 6h;80%
With potassium carbonate In acetone for 24h; Reflux;51%
With potassium carbonate In acetone for 24h; Reflux;51%
Stage #1: 1,3-dihydroxyxanthone With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: 1 ,6-dibromohexane In N,N-dimethyl-formamide at 20℃; for 12.5h;
1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

gentitein
529-49-7

gentitein

C19H19BrO5

C19H19BrO5

Conditions
ConditionsYield
Stage #1: gentitein With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: 1 ,6-dibromohexane In N,N-dimethyl-formamide at 20℃; for 20h;
98.6%
Stage #1: gentitein With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: 1 ,6-dibromohexane In N,N-dimethyl-formamide at 20℃; for 12.5h;
1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

1,3-dihydroxy-7-bromo-9H-xanthen-9-one
100334-97-2

1,3-dihydroxy-7-bromo-9H-xanthen-9-one

C19H18Br2O4

C19H18Br2O4

Conditions
ConditionsYield
Stage #1: 7-bromo-1,3-dihydroxy-9H-xanthen-9-one With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: 1 ,6-dibromohexane In N,N-dimethyl-formamide at 20℃; for 20h;
98.6%
Stage #1: 7-bromo-1,3-dihydroxy-9H-xanthen-9-one With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: 1 ,6-dibromohexane In N,N-dimethyl-formamide at 20℃; for 12.5h;
1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

1,3-dihydroxy-8-methoxy-9H-xanthen-9-one
2980-31-6

1,3-dihydroxy-8-methoxy-9H-xanthen-9-one

C20H21BrO5

C20H21BrO5

Conditions
ConditionsYield
Stage #1: 1,3-dihydroxy-8-methoxy-9H-xanthen-9-one With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: 1 ,6-dibromohexane In N,N-dimethyl-formamide at 20℃; for 20h;
98.6%
Stage #1: 1,3-dihydroxy-8-methoxy-9H-xanthen-9-one With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: 1 ,6-dibromohexane In N,N-dimethyl-formamide at 20℃; for 12.5h;
1-Methylpyrrolidine
120-94-5

1-Methylpyrrolidine

1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

1,6-bis(N-methylpyrrolidinium)hexane bromide
13118-09-7

1,6-bis(N-methylpyrrolidinium)hexane bromide

Conditions
ConditionsYield
for 24h; Reflux;98%
In acetone at 20℃;
In methanol at 20℃; for 96h;
With ethanol
pyridine
110-86-1

pyridine

1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

[1,1'-(hexane-1,6-diyl)bis(pyridinium)] dibromide
53952-75-3

[1,1'-(hexane-1,6-diyl)bis(pyridinium)] dibromide

Conditions
ConditionsYield
for 24h; Heating;98%
In acetonitrile at 70℃; for 24h;93%
In acetonitrile Reflux;88%
1 ,6-dibromohexane
629-03-8

1 ,6-dibromohexane

4-methoxy-phenol
150-76-5

4-methoxy-phenol

6-(4-methoxyphenoxy)hexyl bromide
20744-11-0

6-(4-methoxyphenoxy)hexyl bromide

Conditions
ConditionsYield
With potassium carbonate; potassium iodide In acetone at 65℃;98%
With potassium carbonate; potassium iodide In acetone at 60℃; for 72h;96%
With potassium carbonate; potassium iodide In acetone at 65℃; Inert atmosphere;95.2%

1,6-Dibromohexane Chemical Properties

Molecular Structure of 1,6-Dibromohexane (CAS NO.629-03-8):

IUPAC Name: 1,6-dibromohexane 
Empirical Formula: C6H12Br2
Molecular Weight: 243.9675
H bond acceptors: 0
H bond donors: 0
Freely Rotating Bonds: 5
Polar Surface Area: 0 Å2
Index of Refraction: 1.5
Molar Refractivity: 45.3 cm3
Molar Volume: 153.9 cm3
Surface Tension: 35.2 dyne/cm
Density: 1.584 g/cm3
Flash Point: 110.8 °C
Enthalpy of Vaporization: 46.17 kJ/mol
Boiling Point: 244.1 °C at 760 mmHg
Vapour Pressure: 0.0483 mmHg at 25°C
EINECS: 211-067-2
Melting point: −2-2.5 °C(lit.)
Product Categories: Industrial/Fine Chemicals; Dibromoalkane; Bromine Compounds; alpha,omega-Bifunctional Alkanes; alpha,omega-Dibromoalkanes; Monofunctional & alpha,omega-Bifunctional Alkanes

1,6-Dibromohexane Toxicity Data With Reference

1.    

skn-rbt 500 mg MLD

    FCTOD7    Food and Chemical Toxicology. 20 (1982),563.
2.    

eye-rbt 100 mg MLD

    FCTOD7    Food and Chemical Toxicology. 20 (1982),573.
3.    

eye-rbt 100 mg/30S rns MLD

    FCTOD7    Food and Chemical Toxicology. 20 (1982),573.
4.    

mmo-sat 10 µmol/plate

    MUREAV    Mutation Research. 141 (1984),11.
5.    

ipr-mus LD50:270 mg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 14 (1964),668.

1,6-Dibromohexane Consensus Reports

Reported in EPA TSCA Inventory.

1,6-Dibromohexane Safety Profile

Poison by intraperitoneal route. A skin and eye irritant. Mutation data reported. When heated to decomposition it emits very toxic fumes of Br. See also BROMIDES.
Hazard Codes: ToxicT,DangerousN,CorrosiveC
Risk Statements: 25-51/53
R25 :Toxic if swallowed. 
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements: 36-45-61
S36:Wear suitable protective clothing. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.
RIDADR: UN 2810 6.1/PG 3
WGK Germany: 3
RTECS: MO1515000
HazardClass: 9
PackingGroup; III
HS Code: 29033036

1,6-Dibromohexane Specification

  1,6-Dibromohexane , with CAS number of 629-03-8, can be called Hexamethylene dibromide ; 1,6-Dibromo-n-hexane ; a,w-Dibromohexane . It is a colourless or pale yellow liquid. 1,6-Dibromohexane (CAS NO.629-03-8) can be used as intermediates in organic synthesis, or for the production of lowering blood pressure drug-Rokko bromide .

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