1-Benzyl-2-pyrrolidinone supplier

Name
1-Benzyl-2-pyrrolidinone
EINECS 226-131-5
CAS No. 5291-77-0
Article Data84
CAS DataBase
Density 1.134 g/cm³
Solubility Slightly soluble in water.
Melting Point 154 - 156oC
Formula C₁₁H₁₃NO
Boiling Point 343.041 °C at 760 mmHg
Molecular Weight 175.23
Flash Point 141.343 °C
Transport Information
Appearance clear colourless to yellow liquid
Safety 26-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 2-Pyrrolidinone,1-(phenylmethyl)-;2-Pyrrolidinone,1-benzyl- (6CI,7CI,8CI);1-Benzyl-2-oxopyrrolidine;1-Benzylazacyclopentan-2-one;N-Benzyl-2-pyrrolidone;N-Benzylbutyrolactam;N-Benzylpyrrolidin-2-one;N-Benzylpyrrolidone;NSC 30184;
PSA 20.31000
LogP 1.74690

Synthetic route

: 534616-88-1
1-benzylazetidine-2-carbaldehyde

: 5291-77-0
1-benzyl-2-pyrrolidone

Conditions

Conditions	Yield
With 2-pentafluorophenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.5h; Inert atmosphere;	100%

: 96-48-0
4-butanolide

: 100-46-9
benzylamine

: 5291-77-0
1-benzyl-2-pyrrolidone

Conditions

Conditions	Yield
With 1-butyl-3-methylimidazolium Tetrafluoroborate In 1,4-dioxane at 220℃; for 0.583333h; Microwave irradiation;	99%
for 24h; Heating;	79%
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; sodium acetate In toluene at 110℃; for 36h; Reagent/catalyst; Inert atmosphere; Glovebox; Molecular sieve; Schlenk technique;	65%

: 64017-86-3
N-benzyl-4-(benzylamino)butanamide

: 5291-77-0
1-benzyl-2-pyrrolidone

Conditions

Conditions	Yield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; sodium acetate; benzylamine In toluene for 48h; Inert atmosphere; Glovebox; Molecular sieve; Schlenk technique; Reflux;	97%

: 22813-61-2
N-benzyl-4-chlorobutanamide

: 5291-77-0
1-benzyl-2-pyrrolidone

Conditions

Conditions	Yield
With potassium tert-butylate In tetrahydrofuran at 0℃; for 2h;	96%
With sodium hydride In hexane; N,N-dimethyl-formamide; mineral oil at 20℃; for 1h;	96%
With potassium hydroxide

: 1307661-09-1
C18H18ClN

: 5291-77-0
1-benzyl-2-pyrrolidone

Conditions

Conditions	Yield
With tetrakis(trifluoroacetato)rhodium(II); water In toluene for 10h; Reflux; Inert atmosphere; chemoselective reaction;	95%

: 616-45-5
2-pyrrolidinon

: 100-52-7
benzaldehyde

: 5291-77-0
1-benzyl-2-pyrrolidone

Conditions

Conditions	Yield
With hydrogen; sodium sulfate; palladium on activated charcoal In ethyl acetate at 100℃; under 30002.4 Torr; for 4h;	93%
With hydrogen; sodium sulfate; palladium on activated charcoal In ethyl acetate at 100℃; under 30002.4 Torr; for 4h;	93%

: 616-45-5
2-pyrrolidinon

: 100-39-0
benzyl bromide

: 5291-77-0
1-benzyl-2-pyrrolidone

Conditions

Conditions	Yield
With N-benzyl-trimethylammonium hydroxide at 20℃; Neat (no solvent); chemoselective reaction;	92%
Stage #1: 2-pyrrolidinon With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h; Inert atmosphere; Stage #2: benzyl bromide In tetrahydrofuran; mineral oil at 0 - 23℃; for 15h; Inert atmosphere;	83%
Stage #1: 2-pyrrolidinon With sodium hydride In tetrahydrofuran; paraffin oil at 0℃; for 0.5h; Inert atmosphere; Stage #2: benzyl bromide In tetrahydrofuran; paraffin oil at 0 - 20℃; Inert atmosphere;	82%

: 1-benzyl-3-((2,2,6,6-tetramethylpiperidin-1-yl)oxy)-piperidin-2-one

: 5291-77-0
1-benzyl-2-pyrrolidone

Conditions

Conditions	Yield
With 3-chloro-benzenecarboperoxoic acid In diethyl ether at 0℃; for 0.25h; Inert atmosphere;	91.5%

: 1-Benzyl-5-oxo-pyrrolidine-2-carboselenoic acid Se-phenyl ester

: 5291-77-0
1-benzyl-2-pyrrolidone

Conditions

Conditions	Yield
With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride In benzene at 10℃; for 2h; Irradiation;	91%

: 35665-25-9
cyclopropanecarboxylic acid benzylamide

: 5291-77-0
1-benzyl-2-pyrrolidone

Conditions

Conditions	Yield
With carbon tetrabromide; triphenylphosphine In acetonitrile at 60℃; for 10h;	91%

: 616-45-5
2-pyrrolidinon

: 100-44-7
benzyl chloride

: 5291-77-0
1-benzyl-2-pyrrolidone

Conditions

Conditions	Yield
With cesium fluoride In acetonitrile for 48h; Heating;	90%
potassium fluoride on basic alumina In 1,2-dimethoxyethane for 48h; Ambient temperature;	81%
With potassium carbonate; tetrabutylammomium bromide In toluene at 80℃; for 24h; Product distribution; Mechanism; Rate constant; var. time, catalyst; effect of mixing, carbonate and water;	76%

: 26735-10-4
4-(benzylamino)butanoic acid

: 5291-77-0
1-benzyl-2-pyrrolidone

Conditions

Conditions	Yield
With trimethylsilylethoxyacetylene; toluene-4-sulfonic acid; mercury(II) oxide In water; 1,2-dichloro-ethane; acetonitrile at 60℃; for 42h;	87%

: 80251-79-2
(5R)-<5-2H1>-2-pyrrolidinone

: 100-39-0
benzyl bromide

A: 5291-77-0
1-benzyl-2-pyrrolidone

B: 102608-50-4
(5R)-<5-(2)H1>-1-benzylpyrrolidin-2-one

Conditions

Conditions	Yield
With potassium hydroxide; 18-crown-6 ether for 1h; Heating;	A n/a B 85%

...Expand

: 19340-88-6
N-benzyl-4-hydroxybutanamide

: 5291-77-0
1-benzyl-2-pyrrolidone

Conditions

Conditions	Yield
With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; sodium acetate; benzylamine In toluene for 48h; Inert atmosphere; Glovebox; Molecular sieve; Schlenk technique; Reflux;	79%
sulfuric acid for 2h; Heating;

: 74798-56-4
1-benzyl-2-methylpiperidin-3-one

A: 5291-77-0
1-benzyl-2-pyrrolidone

B: 138052-86-5
1-benzyl-2-acetylpyrrolidine

Conditions

Conditions	Yield
With hydrogenchloride for 24h; Heating;	A n/a B 78%

: 96-48-0
4-butanolide

: 100-46-9
benzylamine

A: 19340-88-6
N-benzyl-4-hydroxybutanamide

B: 5291-77-0
1-benzyl-2-pyrrolidone

Conditions

Conditions	Yield
at 150℃; for 0.25h; Microwave irradiation;	A 78% B 8%

...Expand

: 41194-02-9
1-benzyl-5-hydroxypyrrolidin-2-one

: 140-88-5
ethyl acrylate

A: 5291-77-0
1-benzyl-2-pyrrolidone

B: 1393803-16-1
1-benzyl-5-[2-(ethyloxycarbonyl)ethyl]pyrrolidin-2-one

Conditions

Conditions	Yield
With samarium diiodide; boron trifluoride diethyl etherate; tert-butyl alcohol In tetrahydrofuran at -40℃; for 0.166667h;	A 10% B 78%

...Expand

: 105-54-4
butanoic acid ethyl ester

: 100-46-9
benzylamine

: 5291-77-0
1-benzyl-2-pyrrolidone

Conditions

Conditions	Yield
With iron(III) chloride In acetonitrile at 80℃; Sealed tube;	78%

: 41194-02-9
1-benzyl-5-hydroxypyrrolidin-2-one

: 1663-39-4
tert-Butyl acrylate

A: 5291-77-0
1-benzyl-2-pyrrolidone

B: 1393803-37-6
1-benzyl-5-[2-(tert-butyloxycarbonyl)ethyl]pyrrolidin-2-one

Conditions

Conditions	Yield
With samarium diiodide; boron trifluoride diethyl etherate; tert-butyl alcohol In tetrahydrofuran at -40℃; for 0.166667h;	A 8% B 76%

...Expand

: 201230-82-2
carbon monoxide

: 1,3-dibenzyl-1-cyclopropylurea

: 5291-77-0
1-benzyl-2-pyrrolidone

Conditions

Conditions	Yield
Stage #1: carbon monoxide; 1,3-dibenzyl-1-cyclopropylurea With bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; p-N,N-dimethylaminobenzoic acid; triphenylphosphine In 1,2-dichloro-benzene at 130℃; for 72h; Stage #2: With hydrogen; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,2-dichloro-benzene at 140℃; for 36h;	75%

: 41194-02-9
1-benzyl-5-hydroxypyrrolidin-2-one

: 97-63-2
methyl methacrylate

A: 5291-77-0
1-benzyl-2-pyrrolidone

B: 1-benzyl-5-[2-(ethyloxycarbonyl)propyl]pyrrolidin-2-one

Conditions

Conditions	Yield
With samarium diiodide; boron trifluoride diethyl etherate; tert-butyl alcohol In tetrahydrofuran at -40℃; for 0.166667h;	A 17% B 73%

...Expand

: 201230-82-2
carbon monoxide

: 55487-53-1
N-allyl-N-benzyl-acetamide

: 5291-77-0
1-benzyl-2-pyrrolidone

Conditions

Conditions	Yield
With N-methyl-2-pyrrolidone hydrochloride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium(II) iodide at 120℃; under 22801.5 Torr; for 24h; Autoclave;	70%

: 201230-82-2
carbon monoxide

: 13324-66-8
N-benzylcyclopropanamine

: 5291-77-0
1-benzyl-2-pyrrolidone

Conditions

Conditions	Yield
Stage #1: N-benzylcyclopropanamine With isothiocyanatocyclohexane In 1,2-dichloro-benzene at 80℃; for 3h; Inert atmosphere; Stage #2: carbon monoxide With bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; 3-phenoxypropanoic acid; triphenylphosphine In 1,2-dichloro-benzene at 130℃; for 20h;	70%

: 201230-82-2
carbon monoxide

: 1-benzyl-3-cyclohexyl-1-cyclopropylthiourea

: 5291-77-0
1-benzyl-2-pyrrolidone

Conditions

Conditions	Yield
With bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; 3-phenoxypropanoic acid; triphenylphosphine In 1,2-dichloro-benzene at 130℃; for 72h;	68%

: 14468-90-7
N-trimethylsilyl-pyrrolidin-2-one

: 100-39-0
benzyl bromide

: 5291-77-0
1-benzyl-2-pyrrolidone

Conditions

Conditions	Yield
trimethylsilyl trifluoromethanesulfonate at 150 - 160℃; for 0.5h;	66%

methyl γ-aminobutyrate hydrochloride: methyl γ-aminobutyrate hydrochloride

: 100-52-7
benzaldehyde

A: 5291-77-0
1-benzyl-2-pyrrolidone

B: 94914-32-6
methyl 4-(dibenzylamino)butanoate

Conditions

Conditions	Yield
With sodium tris(acetoxy)borohydride; triethylamine In dichloromethane	A 65% B 20%

...Expand

: 41194-02-9
1-benzyl-5-hydroxypyrrolidin-2-one

A: 5291-77-0
1-benzyl-2-pyrrolidone

B: 1,1′-dibenzyl-2,2′-bipyrrolidine-5,5′-dione

C: 1,1′-dibenzyl-2,2′-bipyrrolidine-5,5′-dione

Conditions

Conditions	Yield
With samarium diiodide; boron trifluoride diethyl etherate; tert-butyl alcohol In tetrahydrofuran at -40℃; for 0.166667h; Overall yield = 49 %;	A 65% B n/a C n/a

...Expand

: 41194-02-9
1-benzyl-5-hydroxypyrrolidin-2-one

: 107-13-1
acrylonitrile

A: 5291-77-0
1-benzyl-2-pyrrolidone

B: 1393803-38-7
1-benzyl-5-(2-cyanoethyl)pyrrolidin-2-one

Conditions

Conditions	Yield
With samarium diiodide; boron trifluoride diethyl etherate; tert-butyl alcohol In tetrahydrofuran at -40℃; for 0.166667h;	A 15% B 54%

...Expand

: 4383-22-6
Allylbenzylamine

: 201230-82-2
carbon monoxide

: 5291-77-0
1-benzyl-2-pyrrolidone

Conditions

Conditions	Yield
With sodium tetrahydroborate; carbonylhydridetris(triphenylphosphine)rhodium(I) In dichloromethane; isopropyl alcohol at 100℃; under 26220 Torr; for 24h;	51%

: 79583-98-5
5-azidovaleric acid

: 71-43-2
benzene

A: 5291-77-0
1-benzyl-2-pyrrolidone

B: 3389-54-6
n-benzoylpyrrolidine

Conditions

Conditions	Yield
Stage #1: 5-azidovaleric acid With oxalyl dichloride In dichloromethane at 30℃; for 1.5h; Schmidt Reaction; Stage #2: benzene With trifluorormethanesulfonic acid In dichloromethane at 0 - 60℃; for 46h; Schmidt Reaction;	A 35% B 51%

...Expand

: 5291-77-0
1-benzyl-2-pyrrolidone

: 29897-82-3
N-benzylpyrrolidine

Conditions

Conditions	Yield
With 9-borabicyclo[3.3.1]nonane dimer In tetrahydrofuran at 65℃; for 1h;	96%
With sodium tetrahydroborate; titanium tetrachloride In 1,2-dimethoxyethane for 14h; Ambient temperature;	93%
With Dimethylphenylsilane In ethyl acetate at 20 - 80℃; for 24h; Green chemistry;	93%

: 5291-77-0
1-benzyl-2-pyrrolidone

: 201218-09-9
cyclopropyl acetylenyllithium

: 1-benzyl-2,2-bis(cyclopropylethynyl)pyrrolidine

Conditions

Conditions	Yield
Stage #1: 1-benzyl-2-pyrrolidone With 2,6-di-tert-butyl-4-methylpyridine; trifluoromethylsulfonic anhydride In dichloromethane at -78℃; for 0.5h; Inert atmosphere; Stage #2: cyclopropyl acetylenyllithium In tetrahydrofuran; dichloromethane at -78 - 20℃; for 1h; Inert atmosphere;	96%

: 5291-77-0
1-benzyl-2-pyrrolidone

: 17642-88-5
1-benzyl-2-pyrrolidinethione

Conditions

Conditions	Yield
With Lawessons reagent In dichloromethane at 20℃;	95%
With Lawessons reagent In dichloromethane at 20℃; Inert atmosphere;	90%
With Lawessons reagent In benzene for 4h; Reflux;	90%

: 5291-77-0
1-benzyl-2-pyrrolidone

: 4440-01-1
lithium phenylacetylide

: 1-benzyl-2,2-bis(phenylethynyl)pyrrolidine

Conditions

Conditions	Yield
Stage #1: 1-benzyl-2-pyrrolidone With 2,6-di-tert-butyl-4-methylpyridine; trifluoromethylsulfonic anhydride In dichloromethane at -78℃; for 0.5h; Inert atmosphere; Stage #2: lithium phenylacetylide In tetrahydrofuran; dichloromethane at -78 - 20℃; for 1h; Reagent/catalyst; Inert atmosphere;	95%

: 5291-77-0
1-benzyl-2-pyrrolidone

: 60765-09-5
1-lithio-1-nonyne

: 1-benzyl-2,2-di(non-1-yn-1-yl)pyrrolidine

Conditions

Conditions	Yield
Stage #1: 1-benzyl-2-pyrrolidone With 2,6-di-tert-butyl-4-methylpyridine; trifluoromethylsulfonic anhydride In dichloromethane at -78℃; for 0.5h; Inert atmosphere; Stage #2: 1-lithio-1-nonyne In tetrahydrofuran; dichloromethane at -78 - 20℃; for 1h; Inert atmosphere;	95%

: 5291-77-0
1-benzyl-2-pyrrolidone

: 358-23-6
trifluoromethylsulfonic anhydride

: 762-04-9
phosphonic acid diethyl ester

: tetraethyl (1-benzylpyrrolidine-2,2-diyl)bis(phosphonate)

Conditions

Conditions	Yield
Stage #1: 1-benzyl-2-pyrrolidone; trifluoromethylsulfonic anhydride With 2,6-di-tert-butyl-4-methylpyridine In dichloromethane at -78 - 0℃; Stage #2: phosphonic acid diethyl ester In dichloromethane at 0℃; for 5h;	93%

...Expand

: 5291-77-0
1-benzyl-2-pyrrolidone

: 20098-55-9
(Diazo-ethoxycarbonylmethyl)-triethylsilane

: C21H33NO3S

Conditions

Conditions	Yield
With dirhodium tetraacetate In toluene at 70℃; for 16h;	92%

: 5291-77-0
1-benzyl-2-pyrrolidone

: 556-24-1
methyl 3-methylbutanoate

: (rac)-1-benzyl-3-(3-methylbutanoyl)pyrrolidin-2-one

Conditions

Conditions	Yield
Stage #1: 1-benzyl-2-pyrrolidone With lithium diisopropyl amide In tetrahydrofuran; hexane at -78 - -60℃; for 0.666667h; Inert atmosphere; Stage #2: methyl 3-methylbutanoate In tetrahydrofuran; hexane at -78 - 20℃; for 12h; Inert atmosphere;	92%
Stage #1: 1-benzyl-2-pyrrolidone With n-butyllithium; diisopropylamine In tetrahydrofuran at -78℃; Stage #2: methyl 3-methylbutanoate In tetrahydrofuran at -78 - 30℃;	65%

: 5291-77-0
1-benzyl-2-pyrrolidone

: 1885-29-6
anthranilic acid nitrile

: 2-(1-benzyl-pyrrolidin-2-ylideneamino)benzonitrile

Conditions

Conditions	Yield
Stage #1: 1-benzyl-2-pyrrolidone With tin(IV) chloride; trichlorophosphate In tetrahydrofuran; chloroform at 20℃; for 1.5h; Stage #2: anthranilic acid nitrile In tetrahydrofuran; chloroform at 50℃; for 5h;	91%

: 5291-77-0
1-benzyl-2-pyrrolidone

: 75-16-1
methylmagnesium bromide

: 220024-87-3
1-benzyl-2,2-dimethylpyrrolidine

Conditions

Conditions	Yield
With zirconium(IV) chloride In tetrahydrofuran; diethyl ether 1.) -10 deg C, 0.5 h, 2.) 0 deg C to r.t., 4 h;	90%

: 5291-77-0
1-benzyl-2-pyrrolidone

: 4-nitrobenzyl 2-diazo-2-(triethylsilyl)acetate

: C25H32N2O5S

Conditions

Conditions	Yield
With dirhodium tetraacetate In toluene at 70℃; for 16h;	88%

: 5291-77-0
1-benzyl-2-pyrrolidone

: 554-12-1
propanoic acid methyl ester

: (rac)-1-benzyl-3-propionylpyrrolidin-2-one

Conditions

Conditions	Yield
Stage #1: 1-benzyl-2-pyrrolidone With lithium diisopropyl amide In tetrahydrofuran; hexane at -78 - -60℃; for 0.666667h; Inert atmosphere; Stage #2: propanoic acid methyl ester In tetrahydrofuran; hexane at -78 - 20℃; for 12h; Inert atmosphere;	88%
Stage #1: 1-benzyl-2-pyrrolidone With n-butyllithium; diisopropylamine In tetrahydrofuran at -78℃; Stage #2: propanoic acid methyl ester In tetrahydrofuran at -78 - 30℃;	61%

: 5291-77-0
1-benzyl-2-pyrrolidone

: 848414-09-5
5-methanesulfonyl-furan-2-carboxylic acid ethyl ester

: 1-benzyl-3-[hydroxy-(5-methanesulfonyl-furan-2-yl)-methylene]-pyrrolidin-2-one

Conditions

Conditions	Yield
Stage #1: 1-benzyl-2-pyrrolidone With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.783333h; Stage #2: 5-methanesulfonyl-furan-2-carboxylic acid ethyl ester In tetrahydrofuran at -78 - 20℃; for 1.83333h;	87%

: 5291-77-0
1-benzyl-2-pyrrolidone

: 848414-09-5
5-methanesulfonyl-furan-2-carboxylic acid ethyl ester

: 1-benzyl-3-[hydroxy-(5-methanesulfonylfuran-2-yl)methylene]pyrrolidin-2-one

Conditions

Conditions	Yield
Stage #1: 1-benzyl-2-pyrrolidone With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.783333h; Stage #2: 5-methanesulfonyl-furan-2-carboxylic acid ethyl ester In tetrahydrofuran at -78 - 20℃; for 1.83333h;	87%

: 5291-77-0
1-benzyl-2-pyrrolidone

: 925-90-6
ethylmagnesium bromide

: 1228468-95-8
1-benzyl-2,2-diethylpyrrolidine

Conditions

Conditions	Yield
Stage #1: 1-benzyl-2-pyrrolidone With 2,6-di-tert-butyl-4-methylpyridine; trifluoromethylsulfonic anhydride In dichloromethane at -78℃; for 0.75h; Stage #2: ethylmagnesium bromide In diethyl ether; dichloromethane at -78 - 20℃;	87%
Stage #1: 1-benzyl-2-pyrrolidone With 2,6-di-tert-butyl-4-methylpyridine; trifluoromethylsulfonic anhydride In dichloromethane at -78℃; for 0.75h; Inert atmosphere; Stage #2: ethylmagnesium bromide In dichloromethane at -78 - 20℃; for 3h; Reagent/catalyst; Inert atmosphere;	87%

1-Benzyl-2-pyrrolidinone Specification

The 1-Benzyl-2-pyrrolidinone, with the CAS registry number 5291-77-0, is also known as N-Benzyl-2-pyrrolidone. It belongs to the product categories of Heterocyclic Building Blocks; Pyrrolidines. Its EINECS number is 226-131-5. This chemical's molecular formula is C₁₁H₁₃NO and molecular weight is 175.23. What's more, its systematic name is Methyl 2,6-difluorobenzoate. Its classification codes are: (1)Antineoplastic agents; (2)Drug / Therapeutic Agent; (3)Immunologic Factors; (4)Interferon inducers; (5)Mutation data; (6)Reproductive Effect. This chemical is stable at common pressure and temperature, and it should be sealed and stored in a cool and dry place. Moreover, it should be protected from light.

Physical properties of 1-Benzyl-2-pyrrolidinone are: (1)ACD/LogP: 0.745; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.75; (4)ACD/LogD (pH 7.4): 0.75; (5)ACD/BCF (pH 5.5): 2.17; (6)ACD/BCF (pH 7.4): 2.17; (7)ACD/KOC (pH 5.5): 60.58; (8)ACD/KOC (pH 7.4): 60.58; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 20.31 Å²; (13)Index of Refraction: 1.578; (14)Molar Refractivity: 51.31 cm³; (15)Molar Volume: 154.578 cm³; (16)Polarizability: 20.341×10^-24cm³; (17)Surface Tension: 47.6 dyne/cm; (18)Density: 1.134 g/cm³; (19)Flash Point: 141.343 °C; (20)Enthalpy of Vaporization: 58.686 kJ/mol; (21)Boiling Point: 343.041 °C at 760 mmHg; (22)Vapour Pressure: 0 mmHg at 25°C.

Preparation: this chemical can be prepared by pyrrolidin-2-one and chloromethyl-benzene at the ambient temperature. This reaction will need solvent 1,2-dimethoxy-ethane with the reaction time of 48 hours. This reaction will also need catalyst KF-alumina. The yield is about 81%.

1-Benzyl-2-pyrrolidinone can be prepared by pyrrolidin-2-one and chloromethyl-benzene at the ambient temperature

Uses of 1-Benzyl-2-pyrrolidinone: it can be used to produce 1-benzyl-pyrrolidine at the ambient temperature. It will need reagents TiCl₄, NaBH₄ and solvent 1,2-dimethoxy-ethane with the reaction time of 14 hours. The yield is about 93%.

1-Benzyl-2-pyrrolidinone can be used to produce 1-benzyl-pyrrolidine at the ambient temperature

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need wear suitable protective gloves and eye/face protection.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C2N(Cc1ccccc1)CCC2
(2)Std. InChI: InChI=1S/C11H13NO/c13-11-7-4-8-12(11)9-10-5-2-1-3-6-10/h1-3,5-6H,4,7-9H2
(3)Std. InChIKey: LVUQCTGSDJLWCE-UHFFFAOYSA-N

Product Name

1-Benzyl-2-pyrrolidinone

Synthetic route

1-Benzyl-2-pyrrolidinone Specification

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