1-Cyclohexylethanol supplier

Name
1-Cyclohexylethanol
EINECS 214-780-7
CAS No. 1193-81-3
Article Data202
CAS DataBase
Density 0.928 g/mL at 25 °C(lit.)
Solubility 5.163g/L at 24℃
Melting Point 140 °C
Formula C₈H₁₆O
Boiling Point 189 °C(lit.)
Molecular Weight 128.214
Flash Point 163 °F
Transport Information
Appearance
Safety 23-24/25
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols
Synonyms (1-Hydroxyethyl)cyclohexane;1-Cyclohexane-1-ethanol;1-Cyclohexyl-1-ethanol;Cyclohexylmethylcarbinol;Ethanol, 1-cyclohexyl-;Methanol, cyclohexylmethyl-;Methylcyclohexylcarbinol;Methylcyclohexylmethanol;NSC 44898;NSC 9476;Surflot 944;a-Methylcyclohexanemethanol;
PSA 20.23000
LogP 1.94750

Synthetic route

: 98-86-2
acetophenone

: 1193-81-3
rac-1-cyclohexylethanol

Conditions

Conditions	Yield
With hydrogen In water at 100℃; under 15001.5 Torr; for 0.333333h;	100%
With ruthenium nanoparticles at 120℃; under 90009 Torr; for 2h; Ionic liquid; Autoclave;	99%
With ruthenium; hydrogen In water at 30℃; under 22801.5 Torr; for 12h; Autoclave;	94%

: 823-76-7
Cyclohexyl methyl ketone

: 1193-81-3
rac-1-cyclohexylethanol

Conditions

Conditions	Yield
Stage #1: Cyclohexyl methyl ketone With formic acid; tricarbonyl (4S,7S)-4,7-bis(benzyloxy)-1,3-diphenyl-4,5,6,7-tetrahydro-2H-inden-2-one iron; triethylamine for 0.166667h; Inert atmosphere; Stage #2: With trimethylamine-N-oxide at 60℃; for 48h; Reagent/catalyst; Concentration; Temperature;	97%
With sodium isopropylate; isopropyl alcohol; ruthenium complex C38H42N2O4P2Ru for 5h; Catalytic hydrogenation; Catalytic transfer hydrogenation;	91%
With methanol; sodium tetrahydroborate at 0 - 20℃; for 0.666667h; Inert atmosphere;	88%

: tert-Butyl-(1-cyclohexyl-ethoxy)-dimethyl-silane

: 1193-81-3
rac-1-cyclohexylethanol

Conditions

Conditions	Yield
With water; scandium tris(trifluoromethanesulfonate) In acetonitrile for 4h; Ambient temperature;	97%

: 2747-38-8
methyltrichlorotitanium

: 108-94-1
cyclohexanone

A: 590-67-0
1-Methylcyclohexanol

B: 1193-81-3
rac-1-cyclohexylethanol

Conditions

Conditions	Yield
With Methyltitantrichlorid,Triphenylphosphin; cyclohexanecarbaldehyde In dichloromethane at -25℃; for 6h; Product distribution; other phosphane-complexes and reagents;	A 95% B 3%

...Expand

: 108-94-1
cyclohexanone

MeTiCl3: MeTiCl3

A: 590-67-0
1-Methylcyclohexanol

B: 1193-81-3
rac-1-cyclohexylethanol

Conditions

Conditions	Yield
With Methyltitantrichlorid,Triphenylphosphin; cyclohexanecarbaldehyde In dichloromethane at 0℃; for 6h;	A 95% B 3%

...Expand

: 17328-74-4
2-methyl-1-oxaspiro[2.5]octane

A: 1940-18-7
1-ethylcyclohexanol

B: 1193-81-3
rac-1-cyclohexylethanol

C: 1-(1-chlorocyclohexyl)ethanol

Conditions

Conditions	Yield
With bis(cyclopentadienyl)titanium (III) chloride; cyclohexa-1,4-diene In tetrahydrofuran Product distribution; Mechanism; Ambient temperature; other epoxides, reaction without cyclohexa-1,4-diene;	A 1.5% B 92% C 0.9%
With bis(cyclopentadienyl)titanium (III) chloride; cyclohexa-1,4-diene In tetrahydrofuran Ambient temperature;	A 1.5% B 92% C 0.9%
With bis(cyclopentadienyl)titanium (III) chloride; cyclohexa-1,4-diene In tetrahydrofuran for 0.666667h; Product distribution; Mechanism; other epoxides; other H-atom donors; var. temperature, var. time;	A 1.5% B 64% C 0.9%
With bis(cyclopentadienyl)titanium (III) chloride; cyclohexa-1,4-diene In tetrahydrofuran for 0.25h;	A n/a B 64% C 0.9%
With bis(cyclopentadienyl)titanium (III) chloride; cyclohexa-1,4-diene In tetrahydrofuran for 0.25h; Yields of byproduct given;	A n/a B n/a C 0.9%

...Expand

: 145804-82-6
2-(2,6-dimethoxyphenoxy)-1-phenylethan-1-ol

A: 91-10-1
1,3-dimethoxy-2-hydroxy-benzene

B: 100-41-4
ethylbenzene

C: 1193-81-3
rac-1-cyclohexylethanol

Conditions

Conditions	Yield
With Ni0.85Ru0.15; hydrogen In water at 95℃; under 760.051 Torr; for 16h; Reagent/catalyst;	A 92% B 58% C 22%

...Expand

: (1-cyclohexylethoxy)trimethylsilane

: 1193-81-3
rac-1-cyclohexylethanol

Conditions

Conditions	Yield
With water; boric acid at 20℃; for 1h;	90%

: 2747-38-8
methyltrichlorotitanium

: 2043-61-0
cyclohexanecarbaldehyde

A: 591-78-6
n-hexan-2-one

B: 1193-81-3
rac-1-cyclohexylethanol

Conditions

Conditions	Yield
With n-hexan-2-one; Methyltitantrichlorid,Triphenylphosphin In dichloromethane at -25℃; for 6h; Product distribution; other phosphane-complexes and reagents;	A 6% B 89%

...Expand

: 2043-61-0
cyclohexanecarbaldehyde

MeTiCl3: MeTiCl3

A: 590-67-0
1-Methylcyclohexanol

B: 1193-81-3
rac-1-cyclohexylethanol

Conditions

Conditions	Yield
With n-hexan-2-one; Methyltitantrichlorid,Triphenylphosphin In dichloromethane at -25℃; for 6h;	A 6% B 89%

...Expand

: 7045-86-5
2-methyl-4,7-dihydro-1,3-dioxepine

: 931-50-0
cyclohexylmagnesium bromide

A: 1193-81-3
rac-1-cyclohexylethanol

B: 119624-68-9
(2Z)-4-cyclohexyl-1-hydroxy-2-butene

Conditions

Conditions	Yield
1,2-bis(diphenylphosphino)ethane nickel(II) chloride for 8h; Ambient temperature; Yields of byproduct given;	A n/a B 88%

...Expand

: 18006-13-8
methyltriisopropoxytitanium(IV)

: 2043-61-0
cyclohexanecarbaldehyde

: 1193-81-3
rac-1-cyclohexylethanol

Conditions

Conditions	Yield
In diethyl ether at 0℃; for 0.5h;	85%
In dichloromethane at 22℃; for 0.5h;	95 % Spectr.

: 17328-74-4
2-methyl-1-oxaspiro[2.5]octane

: 1193-81-3
rac-1-cyclohexylethanol

Conditions

Conditions	Yield
With manganese; cyclohexa-1,4-diene; titanocene dichloride; 2,4,6-collidine hydrochloride In tetrahydrofuran for 16h;	81%
With bis(cyclopentadienyl)titanium dichloride; collidine hydrochloride; cyclohexa-1,4-diene; zinc In tetrahydrofuran for 30h; Ambient temperature;	76%

: 35739-70-9
dimethyldichlorotitanium(IV)

: 2043-61-0
cyclohexanecarbaldehyde

: 1193-81-3
rac-1-cyclohexylethanol

Conditions

Conditions	Yield
In dichloromethane at -40℃; for 1h;	78%

: 75-24-1
trimethylaluminum

: 2043-61-0
cyclohexanecarbaldehyde

: 1193-81-3
rac-1-cyclohexylethanol

Conditions

Conditions	Yield
With bis(acetylacetonate)nickel(II); triphenylphosphine In tetrahydrofuran; hexane at 0℃; for 11h;	76%
With 2,7-dimethyl-1,8-biphenylenediol 1.) CH2Cl2, hexane, r.t., 30 min, 2.) CH2Cl2, hexane, -78 deg C, 1 h; Yield given. Multistep reaction;

A

B

C

D

...Expand

A

B

C

...Expand

A

B rac-1-cyclohexylethanol: rac-1-cyclohexylethanol

C: Diphenyl-methanone O-(1-cyclohexyl-ethyl)-oxime

Conditions

Conditions	Yield
In diethyl ether; toluene Heating; Yields of byproduct given;	A n/a B 75% C n/a

...Expand

: 544-97-8
dimethyl zinc(II)

: 106-99-0
buta-1,3-diene

: 2043-61-0
cyclohexanecarbaldehyde

A: 1193-81-3
rac-1-cyclohexylethanol

B: (E)-1-Cyclohexyl-hex-3-en-1-ol

C: (3E,7E)-1-Cyclohexyl-deca-3,7-dien-1-ol

Conditions

Conditions	Yield
bis(acetylacetonate)nickel(II) In tetrahydrofuran; hexane at 25℃; for 1h; Addition;	A 10% B 73% C 17%

...Expand

: 98-86-2
acetophenone

A: 1678-91-7
ethyl-cyclohexane

B: 100-41-4
ethylbenzene

C: 98-85-1, 13323-81-4
1-Phenylethanol

D: 1193-81-3
rac-1-cyclohexylethanol

Conditions

Conditions	Yield
With hydrogen; Pd APII Deloxan at 200℃; under 90007.2 Torr;	A n/a B 69% C n/a D n/a
With hydrogen; Pd APII Deloxan In various solvent(s) at 90℃; under 90007.2 Torr; Product distribution; various temp. and pressures;
With carbon dioxide; hydrogen at 180℃; under 90009 Torr; Supercritical conditions; Flow reactor;	A 17 %Spectr. B 41 %Spectr. C 14 %Spectr. D 28 %Spectr.

...Expand

: 721-04-0
2-phenoxy-1-phenylethanone

A: 98-85-1, 13323-81-4
1-Phenylethanol

B: 1193-81-3
rac-1-cyclohexylethanol

C: 108-93-0
cyclohexanol

D: 108-95-2
phenol

Conditions

Conditions	Yield
With isopropyl alcohol In aq. buffer at 60℃; for 9h; pH=8; Electrochemical reaction;	A 9% B 63% C 69% D 28%

...Expand

: 1193-81-3
rac-1-cyclohexylethanol

: 108-24-7
acetic anhydride

: 13487-27-9
1-cyclohexylethan-1-yl acetate

Conditions

Conditions	Yield
With dmap In ethyl acetate	100%
With copper(II) bis(trifluoromethanesulfonate) In dichloromethane for 0.5h; Ambient temperature;	96%
With copper(II) bis(trifluoromethanesulfonate) In dichloromethane at 20℃; for 1h;	96%

: 79-37-8
oxalyl dichloride

: 1193-81-3
rac-1-cyclohexylethanol

: 2-(1-cyclohexylethoxy)-2-oxoacetic acid

Conditions

Conditions	Yield
In diethyl ether at 0 - 20℃;	100%

: 1193-81-3
rac-1-cyclohexylethanol

: 823-76-7
Cyclohexyl methyl ketone

Conditions

Conditions	Yield
With aluminum oxyhydroxide; ruthenium In toluene at 110℃; for 12h;	99%
With nickel(II) triflate; cyclohexanone; 1,2-bis-(dicyclohexylphosphino)ethane In toluene at 110℃; for 12h; Schlenk technique;	99%
[(η5-(4-HOCH2C6H4)Ph3C4CO)2H]Ru2((CO)4)(μ-H)-SiO2 In toluene at 110℃; for 8h;	97%

: 1193-81-3
rac-1-cyclohexylethanol

: 105-58-8
Diethyl carbonate

: ethyl 1-cyclohexylethyl carbonate

Conditions

Conditions	Yield
aluminum oxide; cesium fluoride at 129.85℃; for 0.75h;	98%
With immobilized 1,5,7-triazabicyclo[4.4.0]dec-5-ene on magnetic γ-Fe2O3 nanoparticles at 125℃; for 6h;	96%

: 1193-81-3
rac-1-cyclohexylethanol

: 999-97-3
1,1,1,3,3,3-hexamethyl-disilazane

: (1-cyclohexylethoxy)trimethylsilane

Conditions

Conditions	Yield
N,N'-dibromo-N,N'-1,2-ethanediylbis-(benzenesulfonamide) at 20℃; for 7.5h;	96%
Stage #1: rac-1-cyclohexylethanol With Iron(III) nitrate nonahydrate; sodium iodide In dichloromethane at 20℃; Stage #2: 1,1,1,3,3,3-hexamethyl-disilazane In dichloromethane at 20℃;	95%
With boric acid In acetonitrile at 20℃; for 1.1h;	95%

: 1193-81-3
rac-1-cyclohexylethanol

ethyl carbonate derivative: ethyl carbonate derivative

: ethyl 1-cyclohexylethyl carbonate

Conditions

Conditions	Yield
With γ-Fe2O3-immobilized 1,5,7-triazabicyclo[4.4.0]dec-5-ene nanoparticles (MNPs-TBD) at 125℃; for 6h;	96%

: 1193-81-3
rac-1-cyclohexylethanol

: C8H15O4S(1-)*Na(1+)

Conditions

Conditions	Yield
Stage #1: rac-1-cyclohexylethanol With sodium hydride In 1,4-dioxane at 20℃; for 1h; Stage #2: With triethylamine sulfurtrioxide In 1,4-dioxane at 20℃;	95%

: 1193-81-3
rac-1-cyclohexylethanol

: C36H24F6O5

: 77507-28-9
1-Cyclohexylethyl α-<1-(9-anthryl)-2,2,2-trifluoroethoxy>acetate

Conditions

Conditions	Yield
With pyridine In tetrahydrofuran	94%

: 876-27-7
4-chlorophenyl acetate

: 1193-81-3
rac-1-cyclohexylethanol

: 58396-29-5
(R)-1-cyclohexylethyl acetate

Conditions

Conditions	Yield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; Candida antarctica B lipase; [RuCl2(p-cymene)]2; (E)-2-((1-hydroxy-2-methylpropan-2-ylimino)methyl)phenol In toluene at 70℃; for 72h; Inert atmosphere; Enzymatic reaction; optical yield given as %ee; enantioselective reaction;	94%
With Novozym 435; In toluene at 70℃; for 48h;

: 108-22-5
Isopropenyl acetate

: 1193-81-3
rac-1-cyclohexylethanol

: 58396-29-5
(R)-1-cyclohexylethyl acetate

Conditions

Conditions	Yield
With dicarbonylchlorido(pentabenzylcyclopentadienyl)ruthenium; potassium tert-butylate; sodium carbonate In tetrahydrofuran; toluene at 23℃; for 3h; Inert atmosphere; dynamic kinetic resolution; Enzymatic reaction; optical yield given as %ee; enantioselective reaction;	94%
With Candida antarctica lipase B; potassium phosphate; C38H24O3Ru In toluene at 50℃; for 20h; Molecular sieve; Inert atmosphere; optical yield given as %ee; enantioselective reaction;	90%
With Candida antarctica lipase B; potassium phosphate; C38H24O3Ru In toluene at 50℃; for 20h; Dynamic kinetic resolution; Molecular sieve; Inert atmosphere; Enzymatic reaction; optical yield given as %ee;	90%
With Candida antarctica lipase B; potassium tert-butylate; sodium carbonate; [chlorodicarbonyl(η-pentaphenylcyclopentadienyl)]Ru(II) In toluene at 20℃; for 17h;	98 % Chromat.
Stage #1: Isopropenyl acetate; rac-1-cyclohexylethanol With Novozym 435 In toluene at 60℃; for 1h; Enzymatic reaction; Stage #2: In toluene at 60℃; for 18h;	n/a

: 1193-81-3
rac-1-cyclohexylethanol

: 613-94-5
benzoic acid hydrazide

: 1431943-16-6
N′-(1-cyclohexylethyl)benzohydrazide

Conditions

Conditions	Yield
With nickel(II) triflate; 1,3-bis(dicyclohexylphosphine)propane In tert-Amyl alcohol at 120℃; for 24h; Inert atmosphere; Glovebox; Schlenk technique; Molecular sieve;	93%
With nickel(II) triflate; 1,1,1,3',3',3'-hexafluoro-propanol; 1,3-bis(dicyclohexylphosphine)propane In tert-Amyl alcohol at 120℃; for 24h; Inert atmosphere; Schlenk technique; Molecular sieve; Sealed tube;	93%

: 1193-81-3
rac-1-cyclohexylethanol

: 120-36-5, 7547-66-2, 15165-69-2, 15165-67-0
(R)-dichlorprop

: (R)-2-(2,4-Dichloro-phenoxy)-propionic acid 1-cyclohexyl-ethyl ester

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In diethyl ether for 4.5h; Ambient temperature;	92%

: 1193-81-3
rac-1-cyclohexylethanol

: 27607-65-4
1,3-dicyclohexylbutan-1-one

Conditions

Conditions	Yield
With [RuCl2(p-cymene)(iPr2-imy)]; tricyclohexylphosphine tetrafluoroborate; potassium hydroxide In toluene at 110℃; for 24h; Schlenk technique; Inert atmosphere;	92%

: 1193-81-3
rac-1-cyclohexylethanol

: 104-94-9
4-methoxy-aniline

: (+)-N-(4-methoxyphenyl)-1-(cyclohexyl)ethyl amine

Conditions

Conditions	Yield
With (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid; (C5(CH3)5)Ir(NHCH(C6H5)CH(C6H5)NSO2C6(CH3)5) In tert-Amyl alcohol for 24h; Inert atmosphere; Glovebox; Molecular sieve; Reflux; enantioselective reaction;	92%

: 1193-81-3
rac-1-cyclohexylethanol

: 98-59-9
p-toluenesulfonyl chloride

: 38293-92-4
1-cyclohexylethyl 4-methylbenzenesulfonate

Conditions

Conditions	Yield
With trimethylamine hydrochloride; triethylamine In dichloromethane at 0℃; Inert atmosphere;	92%
With dmap; triethylamine In dichloromethane at 20℃; for 2h;	86.3%

Conditions

Conditions	Yield
With bis-[(trifluoroacetoxy)iodo]benzene In dichloromethane at 20℃; for 2h; Irradiation;	92%

: Formic acid 1-cyclohexyl-ethyl ester

Conditions

Conditions	Yield
With p-toluenesulfonyl chloride at 20℃; for 0.166667h; neat (no solvent);	91%
With silica triflate In hexane for 0.0833333h; Heating;	90%

: 1193-81-3
rac-1-cyclohexylethanol

(1-methoxymethoxy-ethyl)-cyclohexane: (1-methoxymethoxy-ethyl)-cyclohexane

Conditions

Conditions	Yield
phosphomolybdic acid hydrate at 20℃; for 3.25h;	90%
Fe(HSO4)3 at 20℃; for 2.5h;	74%

: 110-87-2
3,4-dihydro-2H-pyran

: 1193-81-3
rac-1-cyclohexylethanol

Conditions

Conditions	Yield
Stage #1: 3,4-dihydro-2H-pyran With 2Br3(1-)C18H36N2O62H(1+) In acetonitrile at 20℃; for 0.0166667h; Stage #2: rac-1-cyclohexylethanol In acetonitrile at 20℃; for 0.0666667h;	90%
Stage #1: 3,4-dihydro-2H-pyran With C12H24KO6(1+)*Br3H(1-) In acetonitrile at 20℃; for 0.0166667h; Stage #2: rac-1-cyclohexylethanol In acetonitrile at 20℃; for 0.666667h;	86%
With Iron(III) nitrate nonahydrate; sodium iodide In dichloromethane at 20℃; for 0.166667h;	84%

1-Cyclohexylethanol Chemical Properties

Chemical Name: 1-Cyclohexylethanol
IUPAC NAME: 1-Cyclohexylethanol
CAS No.: 1193-81-3
EINECS: 214-780-7
RTECS: GV5776500
RTECS Class: Primary Irritant
Molecular Formula: C₈H₁₆O
Molecular Weight: 128.21 g/mol
Density: 0.884 g/cm³
Flash Point: 80.2 °C
Boiling Point: 192 °C at 760 mmHg
Following is the structure of 1-Cyclohexylethanol (CAS No.1193-81-3):

The chemical synonymous of 1-Cyclohexylethanol (CAS No.1193-81-3) are (R,S)-1-Cyclohexyl-ethanol ; 1-Cyclohexyl-1-ethanol ; 2-Methylcyclohexylmethanol ; alpha-Methyl-cyclohexanemethano ; Cyclohexanemethanol, alpha-methyl- ; Ethanol, 1-cyclohexyl- ; Methanol, cyclohexylmethyl- ; Methylcyclohexylcarbinol

1-Cyclohexylethanol Toxicity Data With Reference

1.	skn-rbt 500 µL/24H SEV	NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) OTS0545755 .
2.	eye-rbt 100 µL/24H MLD	NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) OTS0545755 .
3.	orl-rat LD50:2100 mg/kg	NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) OTS0545755 .
4.	skn-rbt LDLo:1 g/kg	NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) OTS0545755 .

1-Cyclohexylethanol Safety Profile

Moderately toxic by ingestion and skin contact. A severe skin and mild eye irritant. When heated to decomposition it emits acrid smoke and irritating vapors.
Risk Statements about 1-Cyclohexylethanol (CAS No.1193-81-3):
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements about 1-Cyclohexylethanol (CAS No.1193-81-3):
S23:Do not breathe vapour.
S24/25:Avoid contact with skin and eyes.

Product Name

1-Cyclohexylethanol

Synthetic route

1-Cyclohexylethanol Chemical Properties

1-Cyclohexylethanol Toxicity Data With Reference

1-Cyclohexylethanol Safety Profile

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