1-Methoxy-2-propyl acetate supplier

Name
1-Methoxy-2-propyl acetate
EINECS 203-603-9
CAS No. 108-65-6
Density 0.959 g/cm³
Solubility 19.8 g/L (25 °C) in water
Melting Point -87 °C
Formula C₆H₁₂O₃
Boiling Point 154.8 °C at 760 mmHg
Molecular Weight 132.159
Flash Point 47.9 °C
Transport Information UN 3271 3/PG 3
Appearance colourless liquid
Safety 53-25-45
Risk Codes 61-10-36
Molecular Structure
Hazard Symbols T,Xi
Synonyms 2-Propanol,1-methoxy-, acetate (6CI,7CI,8CI,9CI);1-Methoxy-2-acetoxypropane;1-Methoxy-2-propanol acetate;2-Acetoxy-1-methoxypropane;2-Methoxy-1-methylethyl acetate;KR 20;NSC 2207;PGMEA;Propylene glycol 1-methyl ether 2-acetate;1-Methoxy-2-propyl acetate;
PSA 35.53000
LogP 0.58440

Synthetic route

: 2589-57-3
2-(1-methoxycarbonyl-1-methylethylazo)-2-methylpropionic acid methyl ester

: 108-65-6
propylene glycol methyl ether acetate

Conditions

Conditions	Yield
In methanol; hexane; butanone	60%
In methanol; hexane; water; butanone	60%

: 107-98-2
1-methoxy-2-propanol

: 108-24-7
acetic anhydride

: 108-65-6
propylene glycol methyl ether acetate

: 124-41-4
sodium methylate

: 108-24-7
acetic anhydride

: 75-56-9, 16033-71-9
methyloxirane

: 108-65-6
propylene glycol methyl ether acetate

Conditions

Conditions	Yield
(i), (ii) /BRN= 385737/; Multistep reaction;

...Expand

: 79-41-4
poly(methacrylic acid)

: 112-55-0
1-dodecylthiol

: 108-65-6
propylene glycol methyl ether acetate

: 107-98-2
1-methoxy-2-propanol

: 64-19-7
acetic acid

: 108-65-6
propylene glycol methyl ether acetate

Conditions

Conditions	Yield
at 98℃; under 130.002 Torr; Concentration;

: 80-48-8
methyl p-toluene sulfonate

: 108-65-6
propylene glycol methyl ether acetate

Conditions

Conditions	Yield
With dimethyl sulfate

: 64-67-5
diethyl sulfate

: 108-65-6
propylene glycol methyl ether acetate

Conditions

Conditions	Yield
With dimethyl sulfate

: 107-98-2
1-methoxy-2-propanol

: 105-46-4
sec-Butyl acetate

: 108-65-6
propylene glycol methyl ether acetate

Conditions

Conditions	Yield
With sodium methylate at 135℃; for 5h;

: 108-65-6
propylene glycol methyl ether acetate

A: 4188-68-5
methyl (Z)-prop-1-enyl ether

B: 4188-69-6
(E)-1-Methoxy-1-propen

C: 627-40-7
methylallylether

Conditions

Conditions	Yield
at 500℃;

...Expand

: 108-65-6
propylene glycol methyl ether acetate

A: 4188-68-5
methyl (Z)-prop-1-enyl ether

B: 627-40-7
methylallylether

Conditions

Conditions	Yield
at 500℃;

: 108-65-6
propylene glycol methyl ether acetate

A: 4188-69-6
(E)-1-Methoxy-1-propen

B: 627-40-7
methylallylether

Conditions

Conditions	Yield
at 500℃;

: 108-65-6
propylene glycol methyl ether acetate

A: 26550-55-0
(S)-1-Methoxy-propan-2-ol

B: 4984-22-9
(R)-1-methoxy-2-propanol

Conditions

Conditions	Yield
With sodium phosphate buffer; esterase B from Candida antarctica In water at 37℃; for 1h; pH=7.3; Product distribution; Further Variations:; Reagents;

: 868-77-9
2-methyl-2-propenoic acid 2-hydroxyethyl ester

: 79-41-4
poly(methacrylic acid)

: 687-47-8
(S)-Ethyl lactate

: 108-65-6
propylene glycol methyl ether acetate

: 2495-37-6
benzyl methacrylate

Reaxys ID: 15740739: Reaxys ID: 15740739

Conditions

Conditions	Yield
With 2,2'-azobis-(2,4-dimethylvaleronitrile) at 65℃; for 10h;

...Expand

: 211919-60-7
tris[2-(methoxymethoxy)ethyl]amine

: triphenylsulfonium nonafluoro-n-butanesulfonate

Reaxys ID: 11355843: Reaxys ID: 11355843

: 108-65-6
propylene glycol methyl ether acetate

: 108-94-1
cyclohexanone

resist composition: resist composition

...Expand

: 211919-60-7
tris[2-(methoxymethoxy)ethyl]amine

: triphenylsulfonium nonafluoro-n-butanesulfonate

Reaxys ID: 11370510: Reaxys ID: 11370510

: 108-65-6
propylene glycol methyl ether acetate

resist solution: resist solution

...Expand

: 211919-60-7
tris[2-(methoxymethoxy)ethyl]amine

: triphenylsulfonium nonafluoro-n-butanesulfonate

Reaxys ID: 15741265: Reaxys ID: 15741265

: 108-65-6
propylene glycol methyl ether acetate

Reaxys ID: 15741370: Reaxys ID: 15741370

...Expand

Reaxys ID: 11391132: Reaxys ID: 11391132

: 108-65-6
propylene glycol methyl ether acetate

polymer solution: polymer solution

Reaxys ID: 15741359: Reaxys ID: 15741359

: 108-65-6
propylene glycol methyl ether acetate

Reaxys ID: 15741372: Reaxys ID: 15741372

: 108-65-6
propylene glycol methyl ether acetate

terminal carboxylated poly(N,N-dimethylacrylamide): terminal carboxylated poly(N,N-dimethylacrylamide)

: 106-91-2
2,3-Epoxypropyl methacrylate

monoterminally methacryloyl-type poly(N,N-dimethylacrylamide): monoterminally methacryloyl-type poly(N,N-dimethylacrylamide)

Conditions

Conditions	Yield
With tetrabutylammomium bromide; 4-methoxy-phenol at 90℃; for 12h;

...Expand

: 108-65-6
propylene glycol methyl ether acetate

monoterminally methacryloyl-substituted poly(N-vinylpyrrolidone): monoterminally methacryloyl-substituted poly(N-vinylpyrrolidone)

monoterminally methacryloyl-type polymethyl methacrylate: monoterminally methacryloyl-type polymethyl methacrylate

: 80-62-6
methacrylic acid methyl ester

poly(methyl methacrylate-g-N-vinylpyrrolidone-g-methyl methacrylate): poly(methyl methacrylate-g-N-vinylpyrrolidone-g-methyl methacrylate)

Conditions

Conditions	Yield
In toluene at 80℃; for 4h;

...Expand

: 108-65-6
propylene glycol methyl ether acetate

monoterminally methacryloyl-type poly(N,N-dimethylacrylamide): monoterminally methacryloyl-type poly(N,N-dimethylacrylamide)

monoterminally methacryloyl-type polymethyl methacrylate: monoterminally methacryloyl-type polymethyl methacrylate

: 80-62-6
methacrylic acid methyl ester

poly(methyl methacrylate-g-N,N-dimethylacryloyl amide-g-methyl methacrylate): poly(methyl methacrylate-g-N,N-dimethylacryloyl amide-g-methyl methacrylate)

Conditions

Conditions	Yield
With 2,2'-azobis-(2,4-dimethylvaleronitrile) In toluene at 80℃; for 6h;

...Expand

: 2680-03-7
N,N-Dimethylacrylamide

: 108-65-6
propylene glycol methyl ether acetate

terminal carboxylated poly(N,N-dimethylacrylamide): terminal carboxylated poly(N,N-dimethylacrylamide)

Conditions

Conditions	Yield
With 2,2'-azobis-(2,4-dimethylvaleronitrile); 3-mercaptopropionic acid at 80℃; for 6h;

: 2680-03-7
N,N-Dimethylacrylamide

: 108-65-6
propylene glycol methyl ether acetate

monoterminally methacryloyl-type polymethyl methacrylate: monoterminally methacryloyl-type polymethyl methacrylate

poly(N,N-dimethylacrylamide-g-methyl methacrylate): poly(N,N-dimethylacrylamide-g-methyl methacrylate)

Conditions

Conditions	Yield
With 2,2'-azobis-(2,4-dimethylvaleronitrile) In toluene at 80℃; for 6h;

...Expand

: 108-65-6
propylene glycol methyl ether acetate

monoterminally methacryloyl-type polymethyl methacrylate: monoterminally methacryloyl-type polymethyl methacrylate

monoterminally methacryloyl-type poly(2-ethyloxazoline): monoterminally methacryloyl-type poly(2-ethyloxazoline)

poly(N,N-dimethylacrylamide-g-methyl methacrylate): poly(N,N-dimethylacrylamide-g-methyl methacrylate)

Conditions

Conditions	Yield
With 2,2'-azobis-(2,4-dimethylvaleronitrile) In toluene at 75℃; for 6h;

...Expand

: 107-98-2
1-methoxy-2-propanol

: 79-41-4
poly(methacrylic acid)

: 108-65-6
propylene glycol methyl ether acetate

: 106-91-2
2,3-Epoxypropyl methacrylate

: 80-62-6
methacrylic acid methyl ester

: 97-88-1
2-methyl-butyl acrylate

AP-1: AP-1

Conditions

Conditions	Yield
Stage #1: 1-methoxy-2-propanol; poly(methacrylic acid); methacrylic acid methyl ester; 2-methyl-butyl acrylate With 2,2'-azobis(isobutyronitrile); 2-hydroxyethanethiol at 90℃; for 4h; Stage #2: propylene glycol methyl ether acetate at 100℃; for 1.5h; Stage #3: 2,3-Epoxypropyl methacrylate With tetrabutylammomium bromide; 4-methoxy-phenol at 80℃; for 8h;

...Expand

: 998-30-1
Triethoxysilane

: 108-65-6
propylene glycol methyl ether acetate

: 780-69-8
triethoxyphenylsilane

: ammonium hydroxide

: siloxane

Conditions

Conditions	Yield
In water

...Expand

: 1-ethylcyclopentyl methacrylate

: 115372-36-6
3-hydroxy-1-adamantyl methacrylate

: 97-64-3, 2676-33-7
ethyl 2-hydroxypropionate

: 101-84-8
diphenylether

: 108-65-6
propylene glycol methyl ether acetate

: 781637-36-3
3,5-bis(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)cyclohexyl methacrylate

4-diacetoxyiodobiphenyl: 4-diacetoxyiodobiphenyl

alpha-(gamma-butyrolactone) methacrylate: alpha-(gamma-butyrolactone) methacrylate

: 297156-50-4
2-isopropyl-2-adamantyl methacrylate

: gamma-butyrolactone methacrylate

: 29420-49-3
potassium nonaflate

: Biphenyl-4-yl(4-phenoxyphenyl)iodonium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate

Conditions

Conditions	Yield
With toluene-4-sulfonic acid In methanol; dichloromethane; water; acetonitrile

...Expand

1-Methoxy-2-propyl acetate Consensus Reports

The International Agency for Research on Cancer (IARC) has not evaluated the carcinogenicity of PROPYLENE GLYCOL MONOMETHYL ETHER ACETATE.

1-Methoxy-2-propyl acetate Standards and Recommendations

DFG MAK: 50 ppm

1-Methoxy-2-propyl acetate Specification

The 1-Methoxy-2-propyl acetate, with the CAS registry number 108-65-6,is also known as 1,2-Propanediol monomethyl ether acetate; Propylene glycol methyl ether acetate; MPA. It belongs to the product categories of Solvent Bottles;Solvent Packaging Options;Solvents.This chemical's molecular formula is C₆H₁₂O₃ and molecular weight is 132.16. What's more,Its systematic name is 2-Methoxy-1-methylethyl acetate.It is colourless liquid,which is stable,flammable,incompatible with strong oxidizing agents,acids,bases.

Physical properties about 1-Methoxy-2-propyl acetate are:
(1)ACD/LogP: 0.481; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.48; (4)ACD/LogD (pH 7.4): 0.48; (5)ACD/BCF (pH 5.5): 1.37; (6)ACD/BCF (pH 7.4): 1.37; (7)ACD/KOC (pH 5.5): 43.49; (8)ACD/KOC (pH 7.4): 43.49; (9)#H bond acceptors: 3; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 4; (12)Index of Refraction: 1.399; (13)Molar Refractivity: 33.325 cm³; (14)Molar Volume: 137.797 cm³; (15)Surface Tension: 26.5 dyne/cm; (16)Density: 0.959 g/cm³; (17)Flash Point: 47.856 °C; (18)Enthalpy of Vaporization: 39.154 kJ/mol; (19)Boiling Point: 154.79 °C at 760 mmHg; (20)Vapour Pressure: 3.125 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES:O=C(OC(C)COC)C;
(2)Std. InChI:InChI=1S/C6H12O3/c1-5(4-8-3)9-6(2)7/h5H,4H2,1-3H3;
(3)Std. InChIKey:LLHKCFNBLRBOGN-UHFFFAOYSA-N.

Uses of 1-Methoxy-2-propyl acetate:
1-Methoxy-2-propyl acetateis used as a solvent in the manufacture of coating polymers such as cellulose acetate butyrate, epoxy resins, nitrocellulose, and phenoxy resins; cosmetic formulations, agricultural products, ink formulations, textile and adhesive products. It is also used as retarder solvent in lacquers, baking elements etc.

Safety Information of 1-Methoxy-2-propyl acetate:
The 1-Methoxy-2-propyl acetate is flammable ,so it need far away from the combustion source.It is irritating to the eyes ,avoid contact with eyes.And it may cause harm to the unborn child.In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .Avoid exposure - obtain special instruction before use.

The toxicity data of 1-Methoxy-2-propyl acetate as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
mouse	LD50	intraperitoneal	750mg/kg (750mg/kg)	National Technical Information Service. Vol. AD691-490,
rabbit	LD50	skin	> 5gm/kg (5000mg/kg)	Dow Chemical Company Reports. Vol. MSD-1582,
rat	LD50	oral	8532mg/kg (8532mg/kg)	Dow Chemical Company Reports. Vol. MSD-1582,

Product Name

1-Methoxy-2-propyl acetate

Synthetic route

1-Methoxy-2-propyl acetate Consensus Reports

1-Methoxy-2-propyl acetate Standards and Recommendations

1-Methoxy-2-propyl acetate Specification

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