1-Naphthalenesulfonic acid supplier

Name
1-Naphthalenesulfonic acid
EINECS 201-610-1
CAS No. 85-47-2
Article Data77
CAS DataBase
Density 1.423 g/cm³
Solubility freely soluble in water
Melting Point 77-79 °C(lit.)
Formula C10H8 O3 S
Boiling Point 392oC
Molecular Weight 208.238
Flash Point 380.2oC
Transport Information UN 2583
Appearance grey fine crystalline powder
Safety 26-36/37/39-45-28A
Risk Codes R34
Molecular Structure
Hazard Symbols
Synonyms 1-Sulfonaphthalene;HT 907; a-Naphthalenesulfonic acid
PSA 62.75000
LogP 3.16730

Synthetic route

: 91-20-3
naphthalene

: 85-47-2
1-naphthalenesulfonic acid

Conditions

Conditions	Yield
With sulfur trioxide at 60℃; Temperature; Solvent;	95.7%
With dipyridinium dichromate; sodium hydrogensulfite In neat (no solvent) at 100℃; under 1500.15 Torr; for 0.0916667h; Reagent/catalyst; Microwave irradiation;	75%
With sulfuric acid; silica gel In 1,2-dichloro-ethane at 80℃; for 0.5h;	60%

: 91-20-3
naphthalene

A: 120-18-3
naphthalene-2-sulfonate

B: 85-47-2
1-naphthalenesulfonic acid

Conditions

Conditions	Yield
With sulfuric acid at 160 - 170℃; for 1.5h;	A 88.3% B 8.51%
With sulfuric acid at 120℃; Product distribution; Rate constant; Thermodynamic data; activation energy; microwave or irradiation; regioselectivity;
With sulfuric acid at 120℃; for 0.5h; Product distribution; microwave activation; various power, temperature, reaction time, H2SO4 concentration;

: 85-46-1
1-Naphthalenesulfonyl chloride

: 85-47-2
1-naphthalenesulfonic acid

Conditions

Conditions	Yield
Stage #1: 1-Naphthalenesulfonyl chloride With N-ethyl-N,N-diisopropylamine; Wang resin In dichloromethane at 22℃; Stage #2: With trifluoroacetic acid In dichloromethane for 1h; Further stages.;	85%
With sodium hydrogencarbonate In water at 80 - 90℃;	0.25 g
With water In acetone at 30℃; Kinetics; Mechanism; Thermodynamic data; other temperatures; ΔH(excit.), ΔS(excit.); various concentrations of the reagent and substrate;
Multi-step reaction with 2 steps 1: alcohol; zinc 2: water View Scheme

: 90-14-2
1-Iodonaphthalene

: 85-47-2
1-naphthalenesulfonic acid

Conditions

Conditions	Yield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; Aminoiminomethanesulfinic acid In dimethyl sulfoxide at 100℃; for 14h; Green chemistry;	71%

: 15980-15-1
1,4-Oxathiane

: 91-20-3
naphthalene

: 85-47-2
1-naphthalenesulfonic acid

Conditions

Conditions	Yield
With chlorosulphuric acid; benzene

: 91-20-3
naphthalene

A: 85-47-2
1-naphthalenesulfonic acid

B: 85-46-1
1-Naphthalenesulfonyl chloride

Conditions

Conditions	Yield
With tetrachloromethane; chlorosulfonic acid at -5℃;

: 607-33-0
naphthalene-1-sulphinic acid

A: 85-47-2
1-naphthalenesulfonic acid

B: 49833-22-9
S-(naphthalen-1-yl) naphthalene-1-sulfonothioate

Conditions

Conditions	Yield
With water

: 876483-30-6
naphthalene-1-sulfonic acid menthyl ester

A: 85-47-2
1-naphthalenesulfonic acid

B: 500-00-5
3-p-menthene

Conditions

Conditions	Yield
under 4 Torr; bei der Destillation.Thermolysis; naphthalene-1-sulfonic acid l-menthyl ester;

: 91-20-3
naphthalene

A: 120-18-3
naphthalene-2-sulfonate

B: 85-47-2
1-naphthalenesulfonic acid

C: 5724-16-3
naphthalene-1,7-disulphonic acid

D: 525-37-1
naphthalene-1,6-disulfonic acid

E: 81-04-9
naphthalene-1,5-disulfonate

Conditions

Conditions	Yield
With sulfur trioxide; water Product distribution; multistep reaction; various reaction conditions;

...Expand

: 91-20-3
naphthalene

A: 120-18-3
naphthalene-2-sulfonate

B: 85-47-2
1-naphthalenesulfonic acid

C: 525-37-1
naphthalene-1,6-disulfonic acid

D: 81-04-9
naphthalene-1,5-disulfonate

Conditions

Conditions	Yield
With sulfur trioxide; water 1.) CH2Cl2, 22 deg C, 60 min, 2.) 70 - 80 deg C, 30 min; Multistep reaction. Further byproducts given. Title compound not separated from byproducts;

...Expand

: 91-20-3
naphthalene

: 7664-93-9
sulfuric acid

: 85-47-2
1-naphthalenesulfonic acid

Conditions

Conditions	Yield
at 80℃;

: 91-20-3
naphthalene

: 7664-93-9
sulfuric acid

: 7446-11-9
sulfur trioxide

: 85-47-2
1-naphthalenesulfonic acid

...Expand

: 91-20-3
naphthalene

: 7664-93-9
sulfuric acid

: 7637-07-2
boron trifluoride

: 7732-18-5
water

: 85-47-2
1-naphthalenesulfonic acid

...Expand

: 7790-94-5
chlorosulfonic acid

: 91-20-3
naphthalene

: 71-43-2
benzene

1.4-oxathiane: 1.4-oxathiane

: 85-47-2
1-naphthalenesulfonic acid

Conditions

Conditions	Yield
je ein Mol von Verb. 1 und 2;
je ein Mol von Verb. 1 und 2;

...Expand

: 91-20-3
naphthalene

: 7664-93-9
sulfuric acid

A: 120-18-3
naphthalene-2-sulfonate

B: 85-47-2
1-naphthalenesulfonic acid

Conditions

Conditions	Yield
at 1℃; Product distribution; und 57grad;

...Expand

: 91-20-3
naphthalene

anhydropyridinesulfuric acid: anhydropyridinesulfuric acid

A: 120-18-3
naphthalene-2-sulfonate

B: 85-47-2
1-naphthalenesulfonic acid

Conditions

Conditions	Yield
at 170℃;
at 170℃;

...Expand

: 7790-94-5
chlorosulfonic acid

: 91-20-3
naphthalene

CS2: CS2

A: 120-18-3
naphthalene-2-sulfonate

B: 85-47-2
1-naphthalenesulfonic acid

Conditions

Conditions	Yield
at 100℃; nach Entfernen des CS2;

...Expand

: 56-23-5
tetrachloromethane

: 7790-94-5
chlorosulfonic acid

: 91-20-3
naphthalene

A: 85-47-2
1-naphthalenesulfonic acid

B: 85-46-1
1-Naphthalenesulfonyl chloride

Conditions

Conditions	Yield
at -15 - -5℃; mit 2 Mol von Verb. 1;

...Expand

: 91-20-3
naphthalene

: 7664-93-9
sulfuric acid

A: 85-47-2
1-naphthalenesulfonic acid

B: 5724-16-3
naphthalene-1,7-disulphonic acid

C: 525-37-1
naphthalene-1,6-disulfonic acid

D: 81-04-9
naphthalene-1,5-disulfonate

Conditions

Conditions	Yield
at 40℃; Product distribution;

...Expand

: 91-20-3
naphthalene

A: 120-18-3
naphthalene-2-sulfonate

B: 85-47-2
1-naphthalenesulfonic acid

C naphthalene sulfonic diacids: naphthalene sulfonic diacids

Conditions

Conditions	Yield
With sulfuric acid at 393℃; Kinetics; Rate constant;

...Expand

: 8-hydrazino-naphthalene-1-sulfonic acid

hydrochloride of copper chloride: hydrochloride of copper chloride

: 85-47-2
1-naphthalenesulfonic acid

: 91-20-3
naphthalene

anhydropyridine-sulfuric acid: anhydropyridine-sulfuric acid

A: 120-18-3
naphthalene-2-sulfonate

B: 85-47-2
1-naphthalenesulfonic acid

Conditions

Conditions	Yield
at 110℃;

...Expand

: 607-33-0
naphthalene-1-sulphinic acid

: 7732-18-5
water

A: 85-47-2
1-naphthalenesulfonic acid

B: 49833-22-9
S-(naphthalen-1-yl) naphthalene-1-sulfonothioate

...Expand

: 162109-21-9
4-iodo-naphthalene-1-sulfonic acid

: 7732-18-5
water

: 7758-99-8
copper(II) sulfate

copper: copper

: 85-47-2
1-naphthalenesulfonic acid

Conditions

Conditions	Yield
der Kalium-Salz reagiert;

...Expand

: 162109-21-9
4-iodo-naphthalene-1-sulfonic acid

: 7732-18-5
water

magnesium: magnesium

: 85-47-2
1-naphthalenesulfonic acid

Conditions

Conditions	Yield
der Kalium-Salz reagiert;

...Expand

: 5-iodonaphthalene-1-sulfonic acid

: 7732-18-5
water

zinc: zinc

: 85-47-2
1-naphthalenesulfonic acid

Conditions

Conditions	Yield
der Kalium-Salz reagiert;

...Expand

: 162109-21-9
4-iodo-naphthalene-1-sulfonic acid

: 7732-18-5
water

zinc: zinc

: 85-47-2
1-naphthalenesulfonic acid

Conditions

Conditions	Yield
der Kalium-Salz reagiert;

...Expand

: naphthalene-1-sulfonyl iodide

silver: silver

petroleum ether: petroleum ether

A: 85-47-2
1-naphthalenesulfonic acid

B: 49833-22-9
S-(naphthalen-1-yl) naphthalene-1-sulfonothioate

...Expand

: 109091-37-4
benzoyl-(naphthalene-1-sulfonyl)-amine

aqueous potash: aqueous potash

A: 85-47-2
1-naphthalenesulfonic acid

B: 65-85-0
benzoic acid

...Expand

: 85-47-2
1-naphthalenesulfonic acid

: 13407-53-9
naphthalene-1-sulfonyl azide

Conditions

Conditions	Yield
Stage #1: 1-naphthalenesulfonic acid With trichloroisocyanuric acid; triphenylphosphine In tetrahydrofuran at 0 - 5℃; Stage #2: With sodium azide In tetrahydrofuran at 5 - 20℃;	97%
With sodium azide; trichloroacetonitrile; triphenylphosphine In acetonitrile at 20℃; for 0.5h;	89%

: 85-47-2
1-naphthalenesulfonic acid

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 95-76-1
m,p-dichloroaniline

: 413614-00-3
N-(3,4-dichlorophenyl)-1-naphthalene carboxamide

Conditions

Conditions	Yield
Stage #1: 1-naphthalenesulfonic acid; N,N-dimethyl-formamide With oxalyl dichloride In dichloromethane at 20℃; for 2h; Stage #2: m,p-dichloroaniline With oxalyl dichloride; triethylamine In dichloromethane at 20℃; for 2h;	96%

...Expand

: 85-47-2
1-naphthalenesulfonic acid

: 638-03-9
m-toluidine hydrochloride

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 301822-81-1
N-(3-methylphenyl)-1-naphthalene carboxamide

Conditions

Conditions	Yield
Stage #1: 1-naphthalenesulfonic acid; N,N-dimethyl-formamide With oxalyl dichloride In dichloromethane at 20℃; for 2h; Stage #2: m-toluidine hydrochloride With oxalyl dichloride; triethylamine In dichloromethane at 20℃; for 2h; Cooling with ice;	96%

...Expand

: 85-47-2
1-naphthalenesulfonic acid

: 140-88-5
ethyl acrylate

: (E)-2-(3-ethoxy-3-oxoprop-1-en-1-yl)naphthalene-1-sulfonic acid

Conditions

Conditions	Yield
With silver hexafluoroantimonate; [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; copper(II) acetate monohydrate In N,N-dimethyl-formamide at 120℃; for 16h; Inert atmosphere; diastereoselective reaction;	91%

: 105630-56-6
methyl (2-cyanoethyl)acetoacetate

: 85-47-2
1-naphthalenesulfonic acid

: 107-21-1
ethylene glycol

: 105630-57-7
ethyl 4-cyano-2-(2-methyl-1,3-dioxolan-2-yl)butanoate

Conditions

Conditions	Yield
In toluene	89%

...Expand

: 85-47-2
1-naphthalenesulfonic acid

: 199277-23-1
1-azido-2-(phenylethynyl)benzene

: 2-phenyl-1H-indol-3-yl naphthalene-1-sulfonate

Conditions

Conditions	Yield
With palladium diacetate In 1,4-dioxane at 60℃; for 2h;	87%

: 88333-03-3, 10340-91-7
Benzyl isocyanide

: 85-47-2
1-naphthalenesulfonic acid

: 71862-35-6
naphthalene-1-sulfonic acid benzylamide

Conditions

Conditions	Yield
With water In dichloromethane at 20℃; for 0.333333h;	86%

: 85-47-2
1-naphthalenesulfonic acid

: 8-dichloromethylene dihydrocoptisine

: 8-dichloromethyl coptisine 2-naphthalenesulphonate

Conditions

Conditions	Yield
In ethanol at 80℃; for 1h;	82.4%

: 85-47-2
1-naphthalenesulfonic acid

: naphthalene-1-sulfonate lithium salt

Conditions

Conditions	Yield
Stage #1: 1-naphthalenesulfonic acid With hydrogenchloride; p-toluidine In water at 0℃; for 4h; Inert atmosphere; Stage #2: With n-butyllithium In tetrahydrofuran; hexane at -40 - 20℃; for 12h; Inert atmosphere;	80%

: 85-47-2
1-naphthalenesulfonic acid

: 27768-49-6
1,1’-bis(phenylmethyl)-4,4’bipyridinium bromide

: 1,1'-dibenzyl-4,4'-bipyridinium bis(1-naphthalenesulfonate)

Conditions

Conditions	Yield
In water	79%

: 85-47-2
1-naphthalenesulfonic acid

: 540-51-2
2-bromoethanol

: naphthalene-1-sulfonic acid 2-bromo-ethyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane ice-cooling;	78%

: 760937-92-6
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(1,3-thiazolidin-3-yl)methanone

: 85-47-2
1-naphthalenesulfonic acid

: 3-{(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl}thiazolidine dinaphthalene-1-sulfonate

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 3h;	75%

: 85-47-2
1-naphthalenesulfonic acid

: 85-46-1
1-Naphthalenesulfonyl chloride

Conditions

Conditions	Yield
With phosphorus pentachloride; sodium chloride 1.) pH=neutral with sodium hydrogen carbonate, water, reflux; 2.) 170-180 deg C, 3 h;	68%
With thionyl chloride In diethyl ether Ambient temperature;

: 85-47-2
1-naphthalenesulfonic acid

: 6315-96-4
1-(2-naphthyl)-1-propanone

: 1-(naphthalen-2-yl)-1-oxopropan-2-yl-naphthalene-1-sulfonate

Conditions

Conditions	Yield
With (R)-2-(tert-butylsulfonyl)-6-chloro-2′-iodo-1,1′-biphenyl; 3-chloro-benzenecarboperoxoic acid In ethyl acetate at 20℃; for 72h; Inert atmosphere; enantioselective reaction;	68%

: 85-47-2
1-naphthalenesulfonic acid

: 150322-43-3
prasugel

: 1178975-73-9
prasugrel 1-naphthalenesulfonic acid salt

Conditions

Conditions	Yield
In acetone at 20℃; for 0.333333h;	66%
In acetone at 20℃;

: 85-47-2
1-naphthalenesulfonic acid

: 90-14-2
1-Iodonaphthalene

Conditions

Conditions	Yield
With 2-Iodobenzoic acid; iodine; 3-chloro-benzenecarboperoxoic acid In acetonitrile at 50℃; for 8h; Darkness;	65%

: 85-47-2
1-naphthalenesulfonic acid

: 93-55-0
1-phenyl-propan-1-one

: 1-oxo-1-phenylpropan-2-yl-naphthalene-1-sulfonate

Conditions

Conditions	Yield
With (R)-2-(tert-butylsulfonyl)-6-chloro-2′-iodo-1,1′-biphenyl; 3-chloro-benzenecarboperoxoic acid In ethyl acetate at 20℃; for 72h; Inert atmosphere; enantioselective reaction;	65%

: 85-47-2
1-naphthalenesulfonic acid

: dimethyl 2-((fluoromethyl)(phenyl)-l4-sulfaneylidene)malonate

: fluoromethyl naphthalene-1-sulfonate

Conditions

Conditions	Yield
In acetone at 40℃; for 0.0833333h; Schlenk technique; Inert atmosphere;	63%

: 5337-93-9
4'-methylpropiophenone

: 85-47-2
1-naphthalenesulfonic acid

: 1-oxo-1-(p-tolyl)propan-2-yl-naphthalene-1-sulfonate

Conditions

Conditions	Yield
With (R)-2-(tert-butylsulfonyl)-6-chloro-2′-iodo-1,1′-biphenyl; 3-chloro-benzenecarboperoxoic acid In ethyl acetate at 20℃; for 72h; Inert atmosphere; enantioselective reaction;	63%

: 85-47-2
1-naphthalenesulfonic acid

: 501-65-5
diphenyl acetylene

: 3,4-diphenylnaphtho[1,2-c][1,2]oxathiine 1,1-dioxide

Conditions

Conditions	Yield
With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver(I) acetate In 1,4-dioxane at 100℃; for 16h; Sealed tube; Inert atmosphere; Schlenk technique;	62%

: 85-47-2
1-naphthalenesulfonic acid

: 1403959-51-2
ethyl 5-hydroxy-5-phenylpenta-2,3-dienoate

: (2E,4E)-ethyl 3-((naphthalen-1-ylsulfonyl)oxy)-5-phenylpenta-2,4-dienoate

Conditions

Conditions	Yield
In chloroform at 25℃; Inert atmosphere; stereoselective reaction;	58%

: 85-47-2
1-naphthalenesulfonic acid

: 623-47-2
propynoic acid ethyl ester

: ethyl (Z)-3-(naphthalen-1-ylsulfonyloxy)acrylate

Conditions

Conditions	Yield
With dipotassium peroxodisulfate; palladium diacetate In dichloromethane at 60℃; for 24h; Inert atmosphere; Sealed tube; stereoselective reaction;	56%

: 7796-73-8
3,3-dimethylpent-4-enoic acid

: 85-47-2
1-naphthalenesulfonic acid

A: (5-oxotetrahydrofuran-2-yl)methyl naphthalene-1-sulfonate

B: (5-oxotetrahydrofuran-2-yl)methyl naphthalene-1-sulfonate

Conditions

Conditions	Yield
With (2R,2'R)-2,2'-([2-iodo-1,3-phenylene]bis(oxy))bis(N-mesitylpropanamide); 3-chloro-benzenecarboperoxoic acid In diethyl ether; 2,2,2-trifluoroethanol at -45 - 20℃; for 120h; Solvent; Temperature; enantioselective reaction;	A 35% B n/a

...Expand

: 85-47-2
1-naphthalenesulfonic acid

: 603-36-1
triphenylantimony

: triphenylantimony bis(1-naphthalenesulfonate)

Conditions

Conditions	Yield
With H2O2 In not given	25%
With H2O2 In diethyl ether react. mixt. treated with 30% aq. H2O2, kept at 20°C for 12 h; evapd., recrystd. (toluene), elem. anal.;	25%

1-Naphthalenesulfonic acid Toxicity Data With Reference

Product Name: 1-Naphthalenesulfonic acid (CAS NO.85-47-2)

Molecular Formula: C₁₀H₈O₃S
Molecular Weight: 208.23g/mol
Mol File: 85-47-2.mol
Einecs: 201-610-1
Melting Point: 77-79 °C(lit.)
Density: 1.423 g/cm³
Water Solubility: freely soluble
Product Categories: Intermediates of Dyes and Pigments ; Organic Building Blocks ; Sulfonic/Sulfinic Acids ; Sulfur Compounds
Synonyms of 1-Naphthalenesulfonic acid (CAS NO.85-47-2): 1-Naphthyl sulfonic acid ; Sulfonated naphthalene ; Naphthalene-1-sulfonic acid ; Alpha napthalene sulphonate ; Alpha-naphthalenesulfonic acid ; 1-Naphthalenesulfonic acid ; 1-Naphthalenesulfonic acid, dihydrate ; Naphthalene-1-sulfonic acid dihydrate .

1-Naphthalenesulfonic acid Safety Profile

Safety Information of 1-Naphthalenesulfonic acid (CAS NO.85-47-2):
Hazard Codes: C,F
Risk Statements: 34-11
11: Highly Flammable
34: Causes burns
Safety Statements: 26-36/37/39-45-28-16
16: Keep away from sources of ignition - No smoking
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
28: After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)

Product Name

1-Naphthalenesulfonic acid

Synthetic route

1-Naphthalenesulfonic acid Toxicity Data With Reference

1-Naphthalenesulfonic acid Safety Profile

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