1-PENTYNE supplier | CasNO.627-19-0

Name
1-Pentyne
EINECS 210-987-1
CAS No. 627-19-0
Article Data66
CAS DataBase
Density 0.718 g/cm³
Solubility insoluble in water
Melting Point ?106 to ?105 °C
Formula C5H8
Boiling Point 40.9 °C at 760 mmHg
Molecular Weight 68.1185
Flash Point -34°C
Transport Information
Appearance Clear, colorless liquid
Safety Dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidizing materials. When heated to decomposition it emits acrid smoke and irritating fumes. See also ACETYLENE COMPOUNDS and ALKYNES.
Risk Codes 11-36/37/38-65
Molecular Structure
Hazard Symbols F,Xn
Synonyms 1-Pentine(3CI); Propylacetylene
PSA 0.00000
LogP 1.41970

Synthetic route

: 3234-49-9
1,2-dibromopentane

: 627-19-0
1-Pentyne

Conditions

Conditions	Yield
With potassium hydroxide In xylene Heating;	94%
With Aliquat 336; potassium hydroxide In water at 120℃; for 7h;	80.9%
With petroleum; sodium amide at 160 - 170℃;
With potassium hydroxide; mineral oil at 250℃;

: 17615-01-9
1-(triphenyl-λ5-phosphanylidene)pentan-2-one

: 627-19-0
1-Pentyne

Conditions

Conditions	Yield
at 750℃; under 0.01 Torr;	59%
at 750℃;	59%

: 18643-50-0
1-pentynyl lithium

A: 627-19-0
1-Pentyne

B: 16387-71-6
deca-4,6-diyne

Conditions

Conditions	Yield
With dinitrogen tetraoxide In diethyl ether at -78℃; for 0.166667h; Product distribution;	A 57% B 30%

: 1066-26-8
sodium acetylide

: 106-94-5
propyl bromide

: 627-19-0
1-Pentyne

Conditions

Conditions	Yield
In ammonium hydroxide at -35℃;	56%
With ammonia
With tetrahydrofuran; N,N-dimethyl-formamide
In ammonia at -60℃;
In ammonia Alkylation;

: 110-62-3
pentanal

: 627-19-0
1-Pentyne

Conditions

Conditions	Yield
With Nonafluorobutanesulfonyl fluoride; tert-butylimino-tri(pyrrolidino)phosphorane In N,N-dimethyl-formamide at -10 - 20℃;	53%

: 27593-24-4
hex-2-ynal

: 627-19-0
1-Pentyne

Conditions

Conditions	Yield
With sodium hydroxide In methanol at 85℃;	40%

: 627-21-4
2-Pentyne

: 627-19-0
1-Pentyne

Conditions

Conditions	Yield
With sodium at 100℃; Zers. des gebildeten Natriumpropylacetylens durch Wasser;

: 591-96-8
penta-2,3-diene

: 627-19-0
1-Pentyne

Conditions

Conditions	Yield
With sodium at 100℃; Zers. des gebildeten Natriumpropylacetylens durch Wasser;

: 67747-70-0
2-chloro-pent-2-ene

: 627-19-0
1-Pentyne

: 34238-52-3
3-chloro-2-pentene

: 627-19-0
1-Pentyne

: 42131-85-1
2-chloro-pent-1-ene

: 627-19-0
1-Pentyne

: 31844-95-8
2-bromopent-1-ene

: 627-19-0
1-Pentyne

Conditions

Conditions	Yield
With sodium amide; xylene at 150℃; Zersetzung des Reaktionsprodukts mit Wasser;
Multi-step reaction with 3 steps 1: chloroform; bromine 2: sodium ethylate 3: zinc; alcohol / 78 °C View Scheme

: 26391-15-1
1,2-dibromo-pent-1-ene

: 627-19-0
1-Pentyne

Conditions

Conditions	Yield
With ethanol; zinc at 78℃;

: 598-05-0
di-1-propyl sulfate

: 1066-26-8
sodium acetylide

: 627-19-0
1-Pentyne

Conditions

Conditions	Yield
With ammonia

: 598-23-2
3-methyl-but-1-yne

A: 627-21-4
2-Pentyne

B: 627-19-0
1-Pentyne

Conditions

Conditions	Yield
Isomerisierung;

: 591-95-7
penta-1,2-diene

: 627-19-0
1-Pentyne

Conditions

Conditions	Yield
With petroleum; sodium amide at 140℃;

: 34887-14-4
2,2-dichloro-pentane

: 627-19-0
1-Pentyne

: 600-11-3
2,3-dichloropentane

: 627-19-0
1-Pentyne

: 1066-26-8
sodium acetylide

: 107-08-4
1-iodo-propane

: 627-19-0
1-Pentyne

Conditions

Conditions	Yield
With ammonia under 760 Torr;

: 107-87-9
2-Pentanone

: 627-19-0
1-Pentyne

Conditions

Conditions	Yield
With phosphorus pentachloride; potassium carbonate at 120℃;
Multi-step reaction with 2 steps 1: phosphorus pentachloride View Scheme
Multi-step reaction with 2 steps 1: phosphorus pentachloride View Scheme

: 142-29-0
cyclopentene

A: 2004-70-8
1-methylbuta-1,3-diene

B: 627-19-0
1-Pentyne

Conditions

Conditions	Yield
at 1227℃; Equilibrium constant;

: 689-97-4
3-buten-1-yne

: 4143-42-4
(Z)-azomethane

A: 1574-41-0
Z-piperylene

B: 2004-70-8
1-methylbuta-1,3-diene

C: 627-19-0
1-Pentyne

D: 922-59-8
3-methyl-1-pentyne

E: 2787-45-3
(Z)-3-methyl-1,3-pentadiene

Conditions

Conditions	Yield
In gas at 299.9℃; Thermodynamic data; Rate constant; Kinetics; Heating; other temperature;

...Expand

: 187737-37-7
propene

A: 627-19-0
1-Pentyne

B: 598-23-2
3-methyl-but-1-yne

C: 10288-14-9
6-Methyl-hept-1-en-4-yne

D: 4356-63-2
1,1'-Dimethylethenebisallene

E: 24612-83-7
1-octene-4-yne

F: 120608-97-1
4-Methylhept-1-en-6-yne

Conditions

Conditions	Yield
With Diatomic carbon at -196.1℃; Mechanism;

...Expand

: 60468-23-7
(E)/(Z)-1-bromo-1-pentene

A: 627-19-0
1-Pentyne

B: 142-29-0
cyclopentene

Conditions

Conditions	Yield
With potassium tert-butylate at 240℃; for 0.0166667h; Product distribution; Mechanism;

: 109-67-1
1-penten

A: 627-19-0
1-Pentyne

B: 107-87-9
2-Pentanone

Conditions

Conditions	Yield
With perchloric acid; air; Pd(OAc)2-OPTA In ethanol at 25℃; for 3.5h;	A 89 % Chromat. B 11 % Chromat.
With perchloric acid; air In ethanol at 25℃; for 3.5h; Product distribution; various reaction conditions; also for other n-alkenes;	A 89 % Chromat. B 11 % Chromat.

: 1605-39-6
ethyl 1,2-dipropyl-1-cyclopropene-3-carboxylate

A: 627-19-0
1-Pentyne

B: 16205-90-6
ethyl 2-hexynoate

C: 73368-67-9
(Z)-ethyl 4-oxo-3-propyl-2-hepten-1-oate

D: 73368-65-7
(E)-ethyl 4-oxo-3-propyl-2-hepten-1-oate

E: 107-92-6
butyric acid

Conditions

Conditions	Yield
With oxygen In acetonitrile Product distribution; Mechanism; Irradiation; other solvents (sensitizers: methylene blue, MB; rose bengal, RB; polymer-based rose bengal, p-RB);

...Expand

: 10306-92-0
1,2-di-n-propylcyclopropene

A: 627-19-0
1-Pentyne

B: 30647-86-0
trans-1,3-octadien-5-one

C: 73368-69-1
5-nonyn-4-one

D: 73368-66-8
2-propyl-1-hexen-3-one

Conditions

Conditions	Yield
With oxygen In acetonitrile Irradiation; other solvents (sensitizer: methylene blue, MB; rose bengal, RB); Yield given. Further byproducts given;
With oxygen In acetonitrile Irradiation; other solvents (sensitizer: methylene blue, MB; rose bengal, RB); Further byproducts given;

...Expand

: 10306-92-0
1,2-di-n-propylcyclopropene

A: 627-19-0
1-Pentyne

B: 30647-86-0
trans-1,3-octadien-5-one

C: 73368-69-1
5-nonyn-4-one

D: 73368-66-8
2-propyl-1-hexen-3-one

E: 107-92-6
butyric acid

Conditions

Conditions	Yield
With oxygen In acetonitrile Product distribution; Mechanism; Irradiation; other solvents (sensitizers: methylene blue, MB; rose bengal, RB; polymer based rose bengal, p-RB);

...Expand

: 136449-60-0
Biphenyl-4-yl-dimethyl-pent-1-ynyl-silane

: 627-19-0
1-Pentyne

Conditions

Conditions	Yield
With potassium carbonate In methanol	72 % Chromat.

: 100312-91-2
C5H7(3)H

: 627-19-0
1-Pentyne

Conditions

Conditions	Yield
With amine buffer; water at 25℃; Rate constant; μ = 0.10 M;

: 627-19-0
1-Pentyne

: 143504-44-3
hexakis[2-(dimethylaminomethyl)phenyl]cyclotrisilane

: 158817-37-9
Dimethyl-{2-[1,2,2-tris-(2-dimethylaminomethyl-phenyl)-4-propyl-1,2-dihydro-[1,2]disilet-1-yl]-benzyl}-amine

Conditions

Conditions	Yield
In benzene-d6 at 55℃; for 10h;	100%

: 627-19-0
1-Pentyne

: 100-52-7
benzaldehyde

: 108946-34-5
1-Phenyl-2-hexin-1-ol

Conditions

Conditions	Yield
Stage #1: 1-Pentyne With n-butyllithium In tetrahydrofuran; hexane at -78 - 0℃; for 1.5h; Stage #2: benzaldehyde In tetrahydrofuran; hexane at -78 - 20℃;	100%
Stage #1: 1-Pentyne With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere; Stage #2: benzaldehyde In tetrahydrofuran; hexane at 20℃; for 2h;	98%
Yield given. Multistep reaction;
Stage #1: 1-Pentyne With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Stage #2: benzaldehyde In tetrahydrofuran; hexane at -78 - 0℃; for 6h;

: 627-19-0
1-Pentyne

: 615-43-0
2-iodophenylamine

: 26059-38-1
2-(pent-1-yn-1-yl)aniline

Conditions

Conditions	Yield
With triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide In tetrahydrofuran at 20℃; for 3h; Inert atmosphere;	100%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran at 20℃; for 3h; Inert atmosphere;	94%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In N,N-dimethyl-formamide for 48h; Ambient temperature;	91%

: 109-04-6
2-bromo-pyridine

: 627-19-0
1-Pentyne

: 202828-84-0
2-(pent-1'-ynyl)-pyridine

Conditions

Conditions	Yield
With copper(l) iodide; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride In triethylamine at 25℃; for 16h; Sonogashira coupling;	100%
Stage #1: 2-bromo-pyridine With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine at 25℃; for 0.5h; Inert atmosphere; Stage #2: 1-Pentyne at 25℃; for 16h; Inert atmosphere;	94%
Stage #1: 2-bromo-pyridine With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine at 25℃; for 0.5h; Inert atmosphere; Stage #2: 1-Pentyne at 25℃; for 16h; Inert atmosphere;	94%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide In diethylamine for 20h; Ambient temperature;	84%
Stage #1: 2-bromo-pyridine With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine for 0.5h; Sonogashira Cross-Coupling; Inert atmosphere; Stage #2: 1-Pentyne for 18h; Sonogashira Cross-Coupling; Inert atmosphere; Darkness;	78%

: 627-19-0
1-Pentyne

: 442521-49-5
acetic acid 1-acetoxymethyl-2-(4-bromo-2-nitro-phenyl)-ethyl ester

: 442521-50-8
acetic acid 1-acetoxymethyl-2-(2-nitro-4-pent-1-ynyl-phenyl)-ethyl ester

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran at 20℃; for 18h; Sonogashira coupling;	100%

: 627-19-0
1-Pentyne

: 583-55-1
1-Bromo-2-iodobenzene

: 194092-09-6
1-bromo-2-(n-propylethynyl)benzene

Conditions

Conditions	Yield
With copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) at 20℃; for 8h; Inert atmosphere;	100%
Stage #1: 1-Bromo-2-iodobenzene With bis-triphenylphosphine-palladium(II) chloride; triethylamine for 0.166667h; Sonogashira Cross-Coupling; Inert atmosphere; Stage #2: 1-Pentyne With copper(l) iodide at 20℃; Sonogashira Cross-Coupling; Inert atmosphere;	100%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 50℃; for 4h; Sonogashira coupling;	96%

: 443864-69-5
(2R,3R,4S,5R,6S)-2-(acetoxymethyl)-4-azido-6-(methylthio)tetrahydro-2H-pyran-3,5-diyl diacetate

: 627-19-0
1-Pentyne

: methyl 2,4,6-tri-O-acetyl-3-deoxy-3-(4-propyl-1H-[1,2,3]-triazol-1-yl)-1-thio-β-D-galactopyranoside

Conditions

Conditions	Yield
With copper; N-ethyl-N,N-diisopropylamine In toluene at 45℃;	100%
With N-ethyl-N,N-diisopropylamine; copper(l) iodide In toluene at 50℃; for 72h;	100%
With copper(l) iodide; N-ethyl-N,N-diisopropylamine In toluene at 50℃; for 72h; regioselective reaction;	99%

: 494194-61-5
2,4-dibromo-5-methyl-pyrimidine

: 627-19-0
1-Pentyne

: 5-methyl-2,4-di-pent-1-ynyl-pyrimidine

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide In triethylamine at 50℃; for 3h; Sonogashira coupling;	100%

: 753470-32-5
2,4-dibromo-5,6-dimethyl-pyrimidine

: 627-19-0
1-Pentyne

: 753470-52-9
4,5-dimethyl-2,6-di-pent-1-ynyl-pyrimidine

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide In triethylamine at 50℃; for 3h; Sonogashira coupling;	100%

: 627-19-0
1-Pentyne

: 579-72-6
2-(dimethylamino)benzaldehyde

: 876460-06-9
1-(2-dimethylaminophenyl)hex-2-yn-1-ol

Conditions

Conditions	Yield
Stage #1: 1-Pentyne With n-butyllithium In tetrahydrofuran; hexane at 0℃; for 0.25h; Stage #2: 2-(dimethylamino)benzaldehyde In tetrahydrofuran; hexane for 0.15h;	100%

: 627-19-0
1-Pentyne

: 36239-09-5
ethyl chlorocarbonylacetate

: 861144-51-6
3-oxo-oct-4-ynoic acid ethyl ester

Conditions

Conditions	Yield
Stage #1: 1-Pentyne With isopropylmagnesium chloride In tetrahydrofuran at 20℃; for 6h; Stage #2: ethyl chlorocarbonylacetate In tetrahydrofuran at 0 - 20℃;	100%

: 627-19-0
1-Pentyne

: 15448-47-2
(R)-propylene oxide

: 907157-39-5
(R)-oct-4-yn-2-ol

Conditions

Conditions	Yield
Stage #1: 1-Pentyne With n-butyllithium In tetrahydrofuran; hexane at -40 - 0℃; for 0.5h; Stage #2: (R)-propylene oxide With N,N,N,N,N,N-hexamethylphosphoric triamide In tetrahydrofuran; hexane at -20 - 20℃; for 16.5h;	100%

: 909275-31-6
2-iodophenyl methoxymethyl sulfide

: 627-19-0
1-Pentyne

: 909275-32-7
2-(pent-1-ynyl)phenyl methoxymethyl sulfide

Conditions

Conditions	Yield
With copper(l) iodide; triethylamine; triphenylphosphine; palladium dichloride at 20℃; Sonogashira coupling;	100%

: 627-19-0
1-Pentyne

: 286-20-4
cyclohexane-1,2-epoxide

: trans-2-(1-pentynyl)cyclohexan-1-ol

Conditions

Conditions	Yield
Stage #1: 1-Pentyne With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Stage #2: cyclohexane-1,2-epoxide With boron trifluoride diethyl etherate In tetrahydrofuran; hexane at -78℃; for 3h;	100%
Stage #1: 1-Pentyne With n-butyllithium; boron trifluoride diethyl etherate In tetrahydrofuran at -78℃; for 0.166667h; Inert atmosphere; Stage #2: cyclohexane-1,2-epoxide In tetrahydrofuran at -78℃; for 0.5h; Inert atmosphere; Stage #3: With ammonium chloride In tetrahydrofuran; water	68%

: 627-19-0
1-Pentyne

: 835883-30-2
trifluoro-methanesulfonic acid 3-methoxy-2-methyl-6-nitro-phenyl ester

: 1148008-83-6
C13H15NO3

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetra-(n-butyl)ammonium iodide In triethylamine; acetonitrile Sonogashira-Hagihara coupling; Reflux;	100%

: 627-19-0
1-Pentyne

: 1161720-15-5
N,N-diethyl-2-iodo-3-methoxy-4-(methoxymethoxy)benzamide

: 1161720-16-6
N,N-diethyl-3-methoxy-4-(methoxymethoxy)-2-(pent-1-yn-1-yl)benzamide

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide In diethylamine at 60℃; for 35h; Sonogashira coupling; Inert atmosphere;	100%

: 627-19-0
1-Pentyne

: 610-97-9
o-iodo-methyl-benzoic acid

: 90584-93-3
methyl 2-(pent-1-yn-1-yl)benzoate

Conditions

Conditions	Yield
With copper(l) iodide; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride In N,N-dimethyl-formamide at 20℃; for 24h; Arylation;	99%
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 24h; Condensation;	99%
With triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide In tetrahydrofuran at 20℃; for 24h; Sonogashira coupling reaction;	98%

: 627-19-0
1-Pentyne

: 16387-71-6
deca-4,6-diyne

Conditions

Conditions	Yield
With oxygen; palladium on activated charcoal; copper(l) iodide In dimethyl sulfoxide at 20℃; for 24h;	99%
With N,N,N,N,-tetramethylethylenediamine In dichloromethane at 130℃; under 37503.8 Torr; for 0.333333h; Flow reactor; chemoselective reaction;	98%
With copper(l) iodide; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride In acetonitrile at 25℃; for 24h;	96%

: 627-19-0
1-Pentyne

: 615-41-8
2-iodochlorobenzene

: 600174-97-8
1-(2-chlorophenyl)-1-pentyne

Conditions

Conditions	Yield
With copper(l) iodide; diisopropylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride at 84℃; for 6h; Sonogashira coupling;	99%

: 627-19-0
1-Pentyne

: 445483-23-8
benzyl 2-formyl-4-isopropoxy-5-methoxyphenyl sulfide

: 618388-71-9
benzyl 2-(1-hydroxy-2-hexynyl)-4-isopropoxy-5-methoxyphenyl sulfide

Conditions

Conditions	Yield
Stage #1: 1-Pentyne With n-butyllithium In tetrahydrofuran at -78℃; for 0.15h; Stage #2: benzyl 2-formyl-4-isopropoxy-5-methoxyphenyl sulfide In tetrahydrofuran at 18℃; for 0.25h;	99%

: 627-19-0
1-Pentyne

: 622-79-7
benzyl azide

: 1‐benzyl‐4‐propyl‐1H‐1,2,3‐triazole

Conditions

Conditions	Yield
With triethylamine In neat (no solvent) at 70℃; for 8h; Huisgen Cycloaddition; regioselective reaction;	99%
With [copper(I)]2[(2-picolyliminomethyl)pyrrole]2 In dichloromethane at 20℃; for 4h; Inert atmosphere;	99%
With Cu(I)complex of dendrimer of triazole rings with triethylene glycol termini In water at 30℃; for 24h; Inert atmosphere;	98%

: 1006880-54-1
C10H11F3N2O4S

: 627-19-0
1-Pentyne

: 1006880-56-3
N-(3-pent-1-ynyl-pyridin-2-yl)butyramide

Conditions

Conditions	Yield
With tetra-(n-butyl)ammonium iodide; triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) In acetonitrile at 20℃; Sonogashira coupling;	99%

: 60-29-7
diethyl ether

: 627-19-0
1-Pentyne

: 589-87-7
1,4-bromoiodobenzene

: 3375-31-3
palladium diacetate

: 109027-84-1
1-bromo-4-(pent-1-yn-1-yl)benzene

Conditions

Conditions	Yield
With triphenylphosphine In hexane; triethylamine	99%

...Expand

: 627-19-0
1-Pentyne

: 393860-82-7
3,5-dichloro-1-(4-methoxybenzyl)pyrazin-2(1H)-one

: 1011736-21-2
C17H17ClN2O2

Conditions

Conditions	Yield
With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride In N,N-dimethyl-formamide at 80℃; for 0.166667h; Sonogashira coupling; microwave irradiation;	99%

: 627-19-0
1-Pentyne

: 1066-45-1
trimethyltin(IV)chloride

: 1118-50-9
trimethyl pentynyl stannane

Conditions

Conditions	Yield
With methyllithium In diethyl ether dropwise addn. of CH3Li to a soln. of 1-pentyne (-20°C, inert atmosphere), stirring 1 h, warming to 0°C, addn. of (CH3)3SnCl (ether), warming to room temp. while stirring (12 h); removal of solvent, fractional distillation, distillation;	99%

: 627-19-0
1-Pentyne

: 67460-10-0
2-Iodobenzoic acid,benzyl ester

: o-pent-1-ynylbenzoic acid benzyl ester

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine at 20℃; Sonogashira coupling; Inert atmosphere;	99%

: 627-19-0
1-Pentyne

: 1202528-38-8
6-hydroxymethyl-5-iodo-1-isopropyl-1H-indazole

: 1202528-40-2
6-hydroxymethyl-1-isopropyl-5-(1-pentynyl)-1H-indazole

Conditions

Conditions	Yield
copper(l) iodide; bis(triphenylphosphine)palladium(II)-chloride In N,N-dimethyl-formamide at 20℃; for 12h;	99%

: 627-19-0
1-Pentyne

: 1287206-05-6
[(1S,2S)-1-({(4-bromophenyl)[trans-2-(6-fluoropyridin-2-yl)cyclopropanecarbonyl]amino}methyl)-2-methylbutyl]carbamic acid tert-butyl ester

: ((1S,2S)-1-{[[(1S,2S)-2-(6-fluoropyridin-2-yl)cyclopropanecarbonyl]-(4-pent-1-ynylphenyl)amino]methyl}-2-methylbutyl)carbamic acid t-butyl ester

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride; bis-triphenylphosphine-palladium(II) chloride In tetrahydrofuran at 90℃; for 0.5h; Microwave irradiation;	99%

: 104-53-0
3-phenyl-propionaldehyde

: 627-19-0
1-Pentyne

: 107383-34-6
1-phenyl-4-octyn-3-ol

Conditions

Conditions	Yield
Stage #1: 1-Pentyne With n-butyllithium In tetrahydrofuran; hexane at -78 - -15℃; Inert atmosphere; Stage #2: 3-phenyl-propionaldehyde In tetrahydrofuran; hexane at -78℃; Inert atmosphere;	99%

: 627-19-0
1-Pentyne

: 1387004-47-8
C11H10INO2

: 1439383-33-1
ethyl 5-(pent-1-yn-1-yl)-1H-indole-1-carboxylate

Conditions

Conditions	Yield
Stage #1: 1-Pentyne; C11H10INO2 With bis-triphenylphosphine-palladium(II) chloride; triethylamine In tetrahydrofuran at 20℃; for 0.0833333h; Inert atmosphere; Stage #2: With copper(l) iodide In tetrahydrofuran at 20℃; Inert atmosphere;	99%

1-PENTYNE Chemical Properties

IUPAC Name: 1-Pentyne
The MF of 1-Pentyne (627-19-0) is C₅H₈.

The MW of 1-Pentyne (627-19-0) is 68.12.
Synonyms of 1-Pentyne (627-19-0): Acetylene, propyl- ; Ethylmethylacetylene ; Pent-1-in
Product Categories: Miscellaneous;Acetylenes;Alkynes;Organic Building Blocks;Terminal
Form: Clear colorless to pale yellow liquid
Index of Refraction: 1.401
Density: 0.718 g/ml
Flash Point: -34 °C
Boiling Point: 40.9 °C
Melting Point: -106 °C
Storage temp: 2-8 °C
BRN: 1697133

1-PENTYNE Uses

1-Pentyne (627-19-0) is used as organic synthesis.

1-PENTYNE Safety Profile

Dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidizing materials. When heated to decomposition it emits acrid smoke and irritating fumes. See also ACETYLENE COMPOUNDS and ALKYNES.
Safety information of 1-Pentyne (627-19-0):
Hazard Codes F,Xn
Risk Statements
11 Highly Flammable
36/37/38 Irritating to eyes, respiratory system and skin
65 Harmful: May cause lung damage if swallowed
Safety Statements
16 Keep away from sources of ignition - No smoking
26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36 Wear suitable protective clothing
62 If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label
RIDADR UN 3295 3/PG 2
WGK Germany 3
HazardClass 3
PackingGroup II

Product Name

1-Pentyne

Synthetic route

1-PENTYNE Chemical Properties

1-PENTYNE Uses

1-PENTYNE Safety Profile

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