• Name

  2-(4-Octylphenyl)ethanol

• EINECS
• CAS No. 162358-05-6
• Article Data10
• CAS DataBase
• Density 0.932 g/cm³
• Solubility
• Melting Point
• Formula C₁₆H₂₆O
• Boiling Point 306.257 °C at 760 mmHg
• Molecular Weight 234.382
• Flash Point 116.222 °C
• Transport Information
• Appearance
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms Benzeneethanol, 4-octyl-;2-(4-Octylphenyl)ethan-1-ol;
• PSA 20.23000
• LogP 4.12440

Synthetic route

2-(4-(oct-1-yn-1-yl)phenyl)-1-ethanol

162358-05-6

2-(4-Octylphenyl)ethyl alcohol

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In ethyl acetate at 20℃; for 17h;	98%

162358-04-5

acetic acid 2-(4-octylphenyl)ethyl ester

162358-05-6

2-(4-Octylphenyl)ethyl alcohol

Conditions

Conditions	Yield
With sodium methylate In methanol at 20℃; for 8h;	93%
With sodium methylate In methanol for 6h; Reflux;	92%
With sodium methylate In methanol for 6h; Reflux;	92%

111-83-1

1-bromo-octane

C28H25BrO

162358-05-6

2-(4-Octylphenyl)ethyl alcohol

Conditions

Conditions	Yield
Stage #1: 1-bromo-octane With iodine; magnesium In tetrahydrofuran for 1h; Inert atmosphere; Reflux; Stage #2: C28H25BrO With pyridine; dmap; sodium hydroxide Heating; Stage #3: With palladium 10% on activated carbon; hydrogen In tetrahydrofuran at 120℃; for 4h;	80%

111-83-1

1-bromo-octane

96044-43-8

4-(2-hydroxyethyl)benzyl bromide

162358-05-6

2-(4-Octylphenyl)ethyl alcohol

Conditions

Conditions	Yield
Stage #1: 1-bromo-octane With iodine; magnesium In diethyl ether for 1h; Inert atmosphere; Reflux; Stage #2: 4-(2-hydroxyethyl)benzyl bromide With sodium hydroxide In tetrahydrofuran at 110℃; for 4h; Temperature;	75%

17049-49-9

octylmagnesium bromide

712223-57-9

acetic acid 2-[4-(trifluoromethanesulfonyloxy)phenyl]ethyl ester

A

162358-05-6

2-(4-Octylphenyl)ethyl alcohol

B

162358-04-5

acetic acid 2-(4-octylphenyl)ethyl ester

Conditions

Conditions	Yield
With 1-methyl-pyrrolidin-2-one; iron(III)-acetylacetonate In tetrahydrofuran for 1h;	A 20% B 64%

...Expand

111-85-3

1-Chlorooctane

96044-43-8

4-(2-hydroxyethyl)benzyl bromide

162358-05-6

2-(4-Octylphenyl)ethyl alcohol

Conditions

Conditions	Yield
Stage #1: n-chlorooctane With iodine; magnesium In tetrahydrofuran for 1h; Inert atmosphere; Reflux; Stage #2: 4-(2-hydroxyethyl)benzyl bromide With sodium hydroxide In tetrahydrofuran at 120℃; for 4h;	20%

501-94-0

p-hydroxyphenethyl alcohol

162358-05-6

2-(4-Octylphenyl)ethyl alcohol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 98 percent / NaHSO4 on silica / hexane / 26 h / Heating 2: 94 percent / pyridine / CH2Cl2 / 1 h / 20 °C 3: 20 percent / Fe(acac)3; NMP / tetrahydrofuran / 1 h View Scheme

58556-55-1

2-(4-hydroxyphenyl)ethyl acetate

162358-05-6

2-(4-Octylphenyl)ethyl alcohol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 94 percent / pyridine / CH2Cl2 / 1 h / 20 °C 2: 20 percent / Fe(acac)3; NMP / tetrahydrofuran / 1 h View Scheme

111-64-8

n-octanoic acid chloride

162358-05-6

2-(4-Octylphenyl)ethyl alcohol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 43 percent / AlCl3 / 1,2-dichloro-ethane / 3 h / 20 °C 2: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C 3: 3.40 g / NaOMe; MeOH / 2 h / Heating View Scheme
Multi-step reaction with 3 steps 1.1: aluminum (III) chloride / 1,2-dichloro-ethane / 1 h / 20 °C 1.2: 12 h / 20 °C 2.1: trifluoroacetic acid; triethylsilane / 3 h / 20 °C 3.1: sodium methylate / methanol / 6 h / Reflux View Scheme
Multi-step reaction with 3 steps 1.1: aluminum (III) chloride / 1,2-dichloro-ethane / 1 h / 20 °C 1.2: 12 h / 20 °C 2.1: trifluoroacetic acid; triethylsilane / 3 h / 20 °C 3.1: sodium methylate / methanol / 6 h / Reflux View Scheme
Multi-step reaction with 3 steps 1: aluminum (III) chloride / 1,2-dichloro-ethane / 0 - 20 °C 2: triethylsilane; trifluoroacetic acid / 20 °C 3: sodium methylate / methanol / 3 h / 20 °C View Scheme
Multi-step reaction with 4 steps 1.1: aluminum (III) chloride / 0.01 h / 0.25 - 0.3 °C 1.2: 0 h / 0.2 - 0.5 °C 2.1: sodium hydroxide / water; methanol / 1.5 h / 0.1 - 0.3 °C 3.1: palladium 10% on activated carbon; hydrogen / 0 h / 0.4 °C / Autoclave 4.1: sodium hydroxide / water; methanol / 0.2 - 0.3 °C View Scheme

103-45-7

acetic acid phenethyl ester

162358-05-6

2-(4-Octylphenyl)ethyl alcohol

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 43 percent / AlCl3 / 1,2-dichloro-ethane / 3 h / 20 °C 2: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C 3: 3.40 g / NaOMe; MeOH / 2 h / Heating View Scheme
Multi-step reaction with 3 steps 1.1: aluminum (III) chloride / 1,2-dichloro-ethane / 1 h / 20 °C 1.2: 12 h / 20 °C 2.1: trifluoroacetic acid; triethylsilane / 3 h / 20 °C 3.1: sodium methylate / methanol / 6 h / Reflux View Scheme
Multi-step reaction with 3 steps 1.1: aluminum (III) chloride / 1,2-dichloro-ethane / 1 h / 20 °C 1.2: 12 h / 20 °C 2.1: trifluoroacetic acid; triethylsilane / 3 h / 20 °C 3.1: sodium methylate / methanol / 6 h / Reflux View Scheme
Multi-step reaction with 4 steps 1.1: aluminum (III) chloride / 0.01 h / 0.25 - 0.3 °C 1.2: 0 h / 0.2 - 0.5 °C 2.1: sodium hydroxide / water; methanol / 1.5 h / 0.1 - 0.3 °C 3.1: palladium 10% on activated carbon; hydrogen / 0 h / 0.4 °C / Autoclave 4.1: sodium hydroxide / water; methanol / 0.2 - 0.3 °C View Scheme

162358-03-4

2-(4-octanoylphenyl)ethyl acetate

162358-05-6

2-(4-Octylphenyl)ethyl alcohol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylsilane; TFA / 1,2-dichloro-ethane / 3 h / 20 °C 2: 3.40 g / NaOMe; MeOH / 2 h / Heating View Scheme
Multi-step reaction with 2 steps 1: trifluoroacetic acid; triethylsilane / 3 h / 20 °C 2: sodium methylate / methanol / 6 h / Reflux View Scheme
Multi-step reaction with 2 steps 1: trifluoroacetic acid; triethylsilane / 3 h / 20 °C 2: sodium methylate / methanol / 6 h / Reflux View Scheme
Multi-step reaction with 2 steps 1: triethylsilane; trifluoroacetic acid / 20 °C 2: sodium methylate / methanol / 3 h / 20 °C View Scheme
Multi-step reaction with 3 steps 1: sodium hydroxide / water; methanol / 1.5 h / 0.1 - 0.3 °C 2: palladium 10% on activated carbon; hydrogen / 0 h / 0.4 °C / Autoclave 3: sodium hydroxide / water; methanol / 0.2 - 0.3 °C View Scheme

52914-23-5

4-iodophenethyl alcohol

162358-05-6

2-(4-Octylphenyl)ethyl alcohol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: tetrakis(triphenylphosphine) palladium(0); copper(l) iodide; triethylamine / 17 h / 20 °C / Inert atmosphere 2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 17 h / 20 °C View Scheme

629-05-0

n-octyne

162358-05-6

2-(4-Octylphenyl)ethyl alcohol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: tetrakis(triphenylphosphine) palladium(0); copper(l) iodide; triethylamine / 17 h / 20 °C / Inert atmosphere 2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 17 h / 20 °C View Scheme

124-63-0

methanesulfonyl chloride

162358-05-6

2-(4-Octylphenyl)ethyl alcohol

162358-06-7

4-octylphenethyl methanesulfonate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 5h;	95%
With triethylamine In dichloromethane at 20℃; for 5h;	95%
With triethylamine In dichloromethane for 1h;

162358-05-6

2-(4-Octylphenyl)ethyl alcohol

162358-08-9

diethyl 2-acetamido-2-[2-(4-octylphenyl)ethyl]malonate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: Et3N / CH2Cl2 / 1 h 2.1: 5.37 g / LiI / tetrahydrofuran / 4 h / 20 °C 3.1: NaH / dimethylformamide / 30 h 3.2: 82 percent / dimethylformamide / 1 h / 50 - 60 °C View Scheme
Multi-step reaction with 3 steps 1.1: Et3N / CH2Cl2 / 1 h / 20 °C 2.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 3.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 3.2: 61 percent / ethanol / 3 h / 65 °C View Scheme
Multi-step reaction with 3 steps 1.1: triethylamine / dichloromethane / 0.5 h 1.2: 3 h / 0 - 20 °C 2.1: sodium iodide / tetrahydrofuran / 20 °C 3.1: caesium carbonate / dimethyl sulfoxide / 3 h / 60 °C / Inert atmosphere 3.2: 60 - 80 °C View Scheme
Multi-step reaction with 2 steps 1.1: sodium iodide / butanone / 0.67 h / 0.8 - 0.85 °C 2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0.45 - 0.5 °C / Inert atmosphere 2.2: 0.4 - 0.45 °C / Inert atmosphere View Scheme
Multi-step reaction with 3 steps 1: triethylamine / dichloromethane / 0 - 30 °C / Inert atmosphere 2: tetra-(n-butyl)ammonium iodide; sodium iodide / 3 h / Inert atmosphere 3: tetra-(n-butyl)ammonium iodide; caesium carbonate / dimethyl sulfoxide / 25 - 85 °C / Inert atmosphere View Scheme

162358-05-6

2-(4-Octylphenyl)ethyl alcohol

162358-07-8

1-(2-iodoethyl)-4-octylbenzene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Et3N / CH2Cl2 / 1 h 2: 5.37 g / LiI / tetrahydrofuran / 4 h / 20 °C View Scheme
Multi-step reaction with 2 steps 1: Et3N / CH2Cl2 / 1 h / 20 °C 2: 16.0 g / NaI / butan-2-one / 2 h / Heating View Scheme
Multi-step reaction with 2 steps 1.1: triethylamine / dichloromethane / 0.5 h 1.2: 3 h / 0 - 20 °C 2.1: sodium iodide / tetrahydrofuran / 20 °C View Scheme

162358-05-6

2-(4-Octylphenyl)ethyl alcohol

162359-55-9

fingolimod

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1.1: Et3N / CH2Cl2 / 1 h / 20 °C 2.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 3.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 3.2: 61 percent / ethanol / 3 h / 65 °C 4.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C 5.1: 8.25 g / pyridine / 16 h / 20 °C 6.1: 2 N aq. LiOH / methanol / 2 h / Heating View Scheme
Multi-step reaction with 4 steps 1.1: sodium iodide / butanone / 0.67 h / 0.8 - 0.85 °C 2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0.45 - 0.5 °C / Inert atmosphere 2.2: 0.4 - 0.45 °C / Inert atmosphere 3.1: calcium chloride / water; isopropyl alcohol / 0 h / 0.2 - 0.3 °C 3.2: 0.01 h / 0 - 0.5 °C 3.3: 0 h / 0.15 - 0.5 °C 4.1: sodium hydroxide / water; methanol / 2 h / Reflux View Scheme

162358-05-6

2-(4-Octylphenyl)ethyl alcohol

296282-46-7

2-amino-2-hydroxymethyl-4-(4-octyl-phenyl)-butyric acid

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: Et3N / CH2Cl2 / 1 h / 20 °C 2.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 3.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 3.2: 75 percent / ethanol / 3 h / 65 °C 4.1: 54 percent / LiBH4 / tetrahydrofuran / 6 h / Heating 5.1: 66 percent / aq. HCl; AcOH / 7 h / Heating View Scheme

162358-05-6

2-(4-Octylphenyl)ethyl alcohol

3-isocyanato-3-[2-(4-octyl-phenyl)-ethyl]-dihydro-furan-2-one

Conditions

Conditions	Yield
Multi-step reaction with 8 steps 1.1: Et3N / CH2Cl2 / 1 h / 20 °C 2.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 3.1: NaH / dimethylformamide / 0.5 h 3.2: dimethylformamide / 3 h 4.1: 1 N aq. HCl / methanol / 5 h 5.1: 0.25 N aq. NaOH / acetone / 1.5 h / 20 °C 6.1: Et3N / tetrahydrofuran / 0.25 h / -5 °C 7.1: aq. NaN3 / tetrahydrofuran / 1 h / 0 °C 8.1: benzene / 1 h / Heating View Scheme

162358-05-6

2-(4-Octylphenyl)ethyl alcohol

2-amino-2-[2-(4-octylphenyl)ethyl]butane-1,4-diol

Conditions

Conditions

Yield

Multi-step reaction with 13 steps 1.1: Et3N / CH2Cl2 / 1 h / 20 °C 2.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 3.1: NaH / dimethylformamide / 0.5 h 3.2: dimethylformamide / 3 h 4.1: 1 N aq. HCl / methanol / 5 h 5.1: 0.25 N aq. NaOH / acetone / 1.5 h / 20 °C 6.1: Et3N / tetrahydrofuran / 0.25 h / -5 °C 7.1: aq. NaN3 / tetrahydrofuran / 1 h / 0 °C 8.1: benzene / 1 h / Heating 9.1: benzene / 7 h / Heating 10.1: LiBH4 / tetrahydrofuran / 0.5 h / Heating 11.1: pyridine / 13 h / 20 °C 12.1: Me3SiI / CH2Cl2 / 7 h 12.2: pyridine / 13 h 13.1: 2 M aq. LiOH / tetrahydrofuran; methanol / 2 h / Heating View Scheme

162358-05-6

2-(4-Octylphenyl)ethyl alcohol

296282-78-5

N-[1-cyano-1-hydroxymethyl-3-(4-octylphenyl)propyl]acetamide

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: Et3N / CH2Cl2 / 1 h / 20 °C 2.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 3.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 3.2: 75 percent / ethanol / 3 h / 65 °C 4.1: 54 percent / LiBH4 / tetrahydrofuran / 6 h / Heating View Scheme

162358-05-6

2-(4-Octylphenyl)ethyl alcohol

1027589-49-6

3-[2-(4-octyl-phenyl)-ethyl]-2-oxo-tetrahydro-furan-3-carboxylic acid

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: Et3N / CH2Cl2 / 1 h / 20 °C 2.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 3.1: NaH / dimethylformamide / 0.5 h 3.2: dimethylformamide / 3 h 4.1: 1 N aq. HCl / methanol / 5 h 5.1: 0.25 N aq. NaOH / acetone / 1.5 h / 20 °C View Scheme

162358-05-6

2-(4-Octylphenyl)ethyl alcohol

2-amino-2-[2-(4-octylphenyl)ethyl]pentane-1,5-diol

Conditions

Conditions

Yield

Multi-step reaction with 11 steps 1.1: Et3N / CH2Cl2 / 1 h / 20 °C 2.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 3.1: NaH / dimethylformamide / 0.5 h 3.2: 76 percent / dimethylformamide / 3 h 4.1: KOH / ethanol / 6 h / 50 °C 5.1: Et3N / tetrahydrofuran / 0.25 h / -5 °C 6.1: aq. NaN3 / tetrahydrofuran / 1 h / 0 °C 7.1: benzene / 1 h / Heating 8.1: benzene / 7 h / Heating 9.1: LiBH4 / tetrahydrofuran / 3 h / Heating 10.1: 5 N aq. KOH / tetrahydrofuran; methanol / 13 h / Heating 11.1: HCl; MeOH / diethyl ether / 0.5 h View Scheme

162358-05-6

2-(4-Octylphenyl)ethyl alcohol

249289-10-9

N-(1-hydroxy-2-(hydroxymethyl)-4-(4-octylphenyl) butan-2-yl) acetamide

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: Et3N / CH2Cl2 / 1 h / 20 °C 2.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 3.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 3.2: 61 percent / ethanol / 3 h / 65 °C 4.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C View Scheme
Multi-step reaction with 4 steps 1.1: triethylamine / dichloromethane / 0.5 h 1.2: 3 h / 0 - 20 °C 2.1: sodium iodide / tetrahydrofuran / 20 °C 3.1: caesium carbonate / dimethyl sulfoxide / 3 h / 60 °C / Inert atmosphere 3.2: 60 - 80 °C 4.1: sodium tetrahydroborate / methanol / 20 °C View Scheme

162358-05-6

2-(4-Octylphenyl)ethyl alcohol

1027929-75-4

3-[2-(4-octyl-phenyl)-ethyl]-2-oxo-tetrahydro-furan-3-carboxylic acid ethyl ester

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: Et3N / CH2Cl2 / 1 h / 20 °C 2.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 3.1: NaH / dimethylformamide / 0.5 h 3.2: dimethylformamide / 3 h 4.1: 1 N aq. HCl / methanol / 5 h View Scheme

162358-05-6

2-(4-Octylphenyl)ethyl alcohol

3-[2-(4-octyl-phenyl)-ethyl]-2-oxo-tetrahydro-furan-3-carbonyl azide

Conditions

Conditions	Yield
Multi-step reaction with 7 steps 1.1: Et3N / CH2Cl2 / 1 h / 20 °C 2.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 3.1: NaH / dimethylformamide / 0.5 h 3.2: dimethylformamide / 3 h 4.1: 1 N aq. HCl / methanol / 5 h 5.1: 0.25 N aq. NaOH / acetone / 1.5 h / 20 °C 6.1: Et3N / tetrahydrofuran / 0.25 h / -5 °C 7.1: aq. NaN3 / tetrahydrofuran / 1 h / 0 °C View Scheme

162358-05-6

2-(4-Octylphenyl)ethyl alcohol

296282-66-1

ethyl 2-acetamido-2-cyano-4-(4-octylphenyl)butyrate

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: Et3N / CH2Cl2 / 1 h / 20 °C 2.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 3.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 3.2: 75 percent / ethanol / 3 h / 65 °C View Scheme

162358-05-6

2-(4-Octylphenyl)ethyl alcohol

177259-57-3

2-Methoxycarbonylamino-2-[2-(4-octylphenyl)ethyl]-γ-butyrolactone

Conditions

Conditions

Yield

Multi-step reaction with 9 steps 1.1: Et3N / CH2Cl2 / 1 h / 20 °C 2.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 3.1: NaH / dimethylformamide / 0.5 h 3.2: dimethylformamide / 3 h 4.1: 1 N aq. HCl / methanol / 5 h 5.1: 0.25 N aq. NaOH / acetone / 1.5 h / 20 °C 6.1: Et3N / tetrahydrofuran / 0.25 h / -5 °C 7.1: aq. NaN3 / tetrahydrofuran / 1 h / 0 °C 8.1: benzene / 1 h / Heating 9.1: benzene / 7 h / Heating View Scheme

162358-05-6

2-(4-Octylphenyl)ethyl alcohol

177258-50-3

2-Methoxycarbonylamino-2-[2-(4-octylphenyl)ethyl]butane 1,4-diol

Conditions

Conditions

Yield

Multi-step reaction with 10 steps 1.1: Et3N / CH2Cl2 / 1 h / 20 °C 2.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 3.1: NaH / dimethylformamide / 0.5 h 3.2: dimethylformamide / 3 h 4.1: 1 N aq. HCl / methanol / 5 h 5.1: 0.25 N aq. NaOH / acetone / 1.5 h / 20 °C 6.1: Et3N / tetrahydrofuran / 0.25 h / -5 °C 7.1: aq. NaN3 / tetrahydrofuran / 1 h / 0 °C 8.1: benzene / 1 h / Heating 9.1: benzene / 7 h / Heating 10.1: LiBH4 / tetrahydrofuran / 0.5 h / Heating View Scheme

162358-05-6

2-(4-Octylphenyl)ethyl alcohol

162358-09-0

2-acetamido-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol diacetate

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: Et3N / CH2Cl2 / 1 h / 20 °C 2.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 3.1: sodium ethoxide / ethanol / 0.5 h / 20 °C 3.2: 61 percent / ethanol / 3 h / 65 °C 4.1: LiAlH4 / tetrahydrofuran / 2 h / 20 °C 5.1: 8.25 g / pyridine / 16 h / 20 °C View Scheme
Multi-step reaction with 3 steps 1.1: sodium iodide / butanone / 0.67 h / 0.8 - 0.85 °C 2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0.45 - 0.5 °C / Inert atmosphere 2.2: 0.4 - 0.45 °C / Inert atmosphere 3.1: calcium chloride / water; isopropyl alcohol / 0 h / 0.2 - 0.3 °C 3.2: 0.01 h / 0 - 0.5 °C 3.3: 0 h / 0.15 - 0.5 °C View Scheme

162358-05-6

2-(4-Octylphenyl)ethyl alcohol

C24H34O6

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1.1: Et3N / CH2Cl2 / 1 h / 20 °C 2.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 3.1: NaH / dimethylformamide / 0.5 h 3.2: dimethylformamide / 3 h 4.1: 1 N aq. HCl / methanol / 5 h 5.1: 0.25 N aq. NaOH / acetone / 1.5 h / 20 °C 6.1: Et3N / tetrahydrofuran / 0.25 h / -5 °C View Scheme

162358-05-6

2-(4-Octylphenyl)ethyl alcohol

177259-09-5

3-Acetamido-3-acetoxymethyl-5-(4-octylphenyl)pentyl acetate

Conditions

Conditions

Yield

Multi-step reaction with 12 steps 1.1: Et3N / CH2Cl2 / 1 h / 20 °C 2.1: 16.0 g / NaI / butan-2-one / 2 h / Heating 3.1: NaH / dimethylformamide / 0.5 h 3.2: dimethylformamide / 3 h 4.1: 1 N aq. HCl / methanol / 5 h 5.1: 0.25 N aq. NaOH / acetone / 1.5 h / 20 °C 6.1: Et3N / tetrahydrofuran / 0.25 h / -5 °C 7.1: aq. NaN3 / tetrahydrofuran / 1 h / 0 °C 8.1: benzene / 1 h / Heating 9.1: benzene / 7 h / Heating 10.1: LiBH4 / tetrahydrofuran / 0.5 h / Heating 11.1: pyridine / 13 h / 20 °C 12.1: Me3SiI / CH2Cl2 / 7 h 12.2: pyridine / 13 h View Scheme

2-(4-Octylphenyl)ethanol Specification